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Dissertations / Theses on the topic 'Stemness'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 June 2025

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1

Jurczak, Daniel. "Stemness in human embryonic stem cells." Thesis, University of Skövde, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3509.

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<p>Stem cells are cells that have a unique ability to divide for an indefinite period. Additionally, they can give rise to a plethora of specialized cell types. The advent of high-throughput technologies made it possible to investigate gene expression on a large scale. This enabled scientists to perform comprehensive gene profiling studies of stem cells. Several authors have suggested that there might be a common set of genes that control the stemness of stem cells. In this study, we suggest that ”stemness” genes that are related to ”stemness” characteristics show a statistically significant d

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2

GARULLI, Chiara. "BMP4: the crossroad between stemness and cancer." Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401773.

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Increasing evidence supports the theory that tumor growth, maintenance, and recurrence are dependent on a small subset of cells with stem properties, redefined cancer initiating cells (CIC) or cancer stem cells (CSC). Bone morphogenetic proteins (BMPs)are extracellular signalling molecules, member of the transforming growth factor Î² (TGFâ€Î²)superfamily. These factors control various cellular processes, such as proliferation, differentiation, apoptosis and migration. Moreover they are involved in cellâ€fate specification during embryogenesis, in the maintenance of developmental potency in e

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3

Khan, Zarine. "Stemness status in differentiated and undifferentiated glioma cells." Thesis, University of Central Lancashire, 2011. http://clok.uclan.ac.uk/2814/.

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Undifferentiated cancer stem cells (CSCs) with their unique potential of self-renewal and multi-lineage differentiation fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim of this research lies in defining specific and selective marker(s) to isolate glioma stem cells, to explore the differentiation state of brain tumour cells and to determine the protein profile changes that assist tumour cells to sustain stem cell-like characteristics. The three stem cell-related pro

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4

Gandhi, Shaan-Chirag Chandrahas. "Regulation of stemness and differentiation in colorectal cancer." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:a32fd55a-4b1e-4a15-9f79-9fdbd986774a.

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The cancer stem cell (CSC) model of carcinogenesis and progression posits that within a tumor lies a subpopulation of cells that solely possess the ability to initiate a tumor and to differentiate into tumor cell lineages. Although the behavior of such cells is known, the challenge is to identify factors that characterize the CSC subpopulation. In this thesis, cell lines were identified that, when grown in three-dimensions, gave rise to organized colonies containing lumens originating from differentiating cells (“lumen lines”) and to densely-packed, spherical colonies originating from non-diff

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5

Adorno-Cruz, Valery. "Identifying Stemness and Metastasis Drivers in Breast Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case158687657816132.

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6

García-Prat, Laura 1987. "Stemness maintenance in skeletal muscle : a focus on aging." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/482052.

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During aging, muscle stem cell regenerative function declines, being maximal at advanced geriatric age, due to a quiescence-to-senescence transition. How quiescence is maintained over long periods of time remains largely unknown. Here we demonstrate that basal autophagy is indispensable for muscle stem cell quiescence maintenance. Physiological failure of autophagy in aging muscle stem cells or forced genetic impairment in young cells causes senescence entry by loss of proteostasis and increased ROS, resulting in numerical and functional stem cell decline. Autophagy reestablishment reve

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7

Hewabostanthirige, Dhanushka. "Loss of Id4 Promotes Stemness In Prostate Cancer Cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/182.

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Inhibitor of differentiation 4 (ID4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer (PCa). Recent studies have shown that Id4 is highly expressed in the normal prostate and decreases in prostate cancer due to epigenetic silencing. Id4 knockdown in androgen sensitive LNCaP cells has been shown to lead to castration resistant prostate cancer (CRPC) in vitro and in vivo. Id4-/- mice leads to underdeveloped prostate with PIN like lesions without the loss of Androgen Receptor (AR) expression. In this study we demonstrate t

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8

López, Arribillaga Erika 1986. "Notch signalling in intestinal homeostasis and cancer: orchestrator of stemness." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/664090.

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Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally in this context and showed that it contributes to ISC self-renewal capacity. We postulated that it does so by regulating its classical locus Cdkn2a and probably also by supporting DNA damage repair. Yet another level of Notch and Wnt/β-catenin crosstalk was found in colorectal cancer where tumour-associated β-catenin induced Jagged 1 (Jag1) transcription, thus leading to Notch activation. We

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9

Mohammadalipour, Ameneh. "Mechanical Properties of Cancer Cells: A Possible Biomarker for Stemness." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1420642948.

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10

Annett, Stephanie Louise. "The role of FKBPL and its peptide derivatives in targeting stemness." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725332.

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FKBPL is a secreted protein with well-established anti-angiogenic activity and a novel therapeutic peptide, ALM201, derived from the protein has entered Phase l/ll clinical trial in ovarian cancer patients. Ovarian cancer is the most lethal gynaecologic cancer with a high incidence of recurrent chemo-resistant disease and this has been attributed to a subpopulation of cancer stem cells (CSCs), which escape standard therapies and drive metastatic spread. ALM201 binds to the cell surface receptor antigen, CD44, a classic marker of CSCs, and for the first time, we demonstrate ALM201's ability to

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11

Jain, Mayur Vilas. "PKB/Akt kinase localization and role in stemness maintenance in cancer." Doctoral thesis, Linköpings universitet, Avdelningen för cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127477.

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Cancer incidence rates have increased over the last decade. Currently available therapies are only moderately effective in targeting cancer cells. Established cancer treatment protocols fail to eliminate populations of cancer stem cells (CSCs), which develop resistance against the chemotherapeutic drugs and lead to cancer recurrence. Therefore, understanding the mechanisms by which CSCs resist drugs and identifying molecular markers are both necessary to further improve prognosis and to develop new treatment strategies. Increased protein kinase B/Akt1 gene expression and/or activity have been

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12

Mournetas, Virginie. "Defining stemness of human embryonic stem cells : a systems biology approach." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2008879/.

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Human embryonic stem cells (hESCs) are undifferentiated cells arising from the inner cell mass of the blastocyst, which are able to self-renew or differentiate in vitro into specialised cell types. These pluripotent cells are a powerful tool to study human embryonic development and have great potential in the field of regenerative medicine. Human ESC pluripotency is governed by an intrinsic transcriptional network composed of the three well-known transcription factors OCT4, SOX2 and NANOG, whereas the role of extrinsic cell/microenvironment interactions in the maintenance of hESC stemness has

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13

Huisken-Hill, Alyse Lynn. "Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer." CSUSB ScholarWorks, 2016. https://scholarworks.lib.csusb.edu/etd/355.

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Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian Carcinoma (HGSOC) is the most common type of ovarian cancer and causes 90% of ovarian cancer deaths. 80% of patients have reoccurrence within five years and only 15-30% of patients with recurrent metastatic ovarian cancer respond to current therapies, chemotherapy and surgery. One reason for the high reoccurre

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14

Zhuang, Qiuyu. "YAP/TAZ regulate autophagy to support epithelial plasticity and cancer stemness." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3426825.

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YAP and TAZ play a fundamental role in oncogenic transformation, organ development, stem cell amplification and regeneration during tissue damage. YAP and TAZ elicit their biological functions through the transcriptional regulation of downstream genes and effector pathways. We found that autophagy is modulated by YAP and TAZ. Given the central role of YAP and TAZ in mechanotransduction, we also confirmed that the mechanical cues control autophagy through YAP/TAZ. Importantly, autophagy control is integral to YAP/TAZ biology.<br>YAP e TAZ sono dei coattivatori trascrizionali che giocano un ruol

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15

Schaal, Courtney. "Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6582.

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Lung cancer is the leading cause of cancer-related death in both men and women, nationally and internationally and kills more people each year than breast, prostate, and colon cancers combined. Non-small cell lung carcinoma (NSCLC) is the most common histological subtype of lung cancer, and accounts for 85% of all cases. Cigarette smoking is the single greatest risk factor for lung cancer, and is correlated with 80-90% of all lung cancer deaths. Nicotine, the addictive component of tobacco smoke, is not a carcinogen and cannot initiate tumors itself; however, it is known to act as a tumor prom

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16

Friedman, Tiffany Ilene. "Hepatitis B x Antigen Promotes "Stemness" in the Pathogenesis of Hepatocellular Carcinoma." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213115.

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Biology<br>Ph.D.<br>Hepatitis B virus (HBV) is a major etiologic agent of chronic liver disease (CLD) and hepatocellular carcinoma (HCC). The virally encoded X antigen, HBx, contributes importantly to the development of HCC through its trans-activating role in various signal transduction pathways. Pathways implicated in stem cell self-renewal also contribute to carcinogenesis. Thus, experiments were designed to test if HBx triggers malignant transformation by promoting properties that are characteristic of cancer stem cells (CSCs). To test this hypothesis, HBx expressing (HepG2X) and control (

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17

CHURRUCA, SCHUIND ANDER. "The Long Pentraxin 3 contributes to triple negative breast cancer stemness tumorigenicity." Doctoral thesis, Università degli studi di Brescia, 2021. http://hdl.handle.net/11379/554943.

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18

Valerio, Ciccone. "Endothelium as therapeutic target in breast and lung cancer progression: the role of nitric oxide and stemness marker ALDH1A1." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1069378.

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Cancer is the second leading cause of death worldwide. Breast and lung cancers are highly diffused in population with a negative impact on mortality due to the high rate of dissemination and chemoresistance. The understanding of new molecular mechanisms and the introduction of new drugs are key elements in the oncology research. In cancer cells, a deregulation of metabolism and redox balance has been reported, with an increase of the detoxifying systems. High levels of reactive species may induce tumor cells to die. Many chemotherapeutic agents act in this way, shifting the balance towar

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19

Neto, Guilherme Tude Coelho. "Peptídeo antimicrobiano LL-37 e seus efeitos em stemness de diferentes células tumorais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-06032017-104147/.

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Os peptídeos antimicrobianos desempenham papéis protetores críticos em uma gama de doenças humanas, incluindo o câncer. Vários estudos demonstraram funções - tais como proliferação, angiogênese, apoptose e imunomodulação - desses peptídeos em vias cancerígenas cruciais. Investigamos o papel do Peptídeo antimicrobiano LL-37 sobre stemness em câncer de mama (SKBR3) e células de melanoma (A375). Análise por PCR array da expressão diferencial de genes em SKBR3 e A375 com knockdown por siRNA para o mRNA de LL-37 revelou uma regulação negativa de genes relacionados com stemness, incluindo transcript

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20

Morello, Giulia. "Role of the stemness transcription factor ZNF521 in MLL-rearranged acute myeloid leukemia." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424852.

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Acute myeloid leukemias (AMLs) that harbor translocations involving the MLL gene on chromosome 11q23 generate fusion transcripts that give rise novel fusion proteins with potent oncogenic properties and capable to destabilize the normal transcriptional activities. MLL fusion oncoproteins have been shown to initiate leukemic transformation primarily by overexpression of a specific set of genes, including HOXA4, 5, 6, 7, 9, 10 (overall defined as “HOXA-code” genes), MEIS1 (a cofactor of “HOXA-code” proteins) and MYB. It‘s well established that the majority of these genes are involved in normal p

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21

Chadli, Loubna. "Contrôles moléculaires du statut de cellule souche kératinocytaire dans l’épiderme interfolliculaire humain adulte : Rôle des facteurs de transcription de la voie du TGF-β1". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T055.

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Les cellules souches de l’épiderme interfolliculaire humain, appelées cellules souches kératinocytaires (CSK), assurent l’homéostasie et le renouvellement du tissu durant toute la vie d’un individu grâce à leur importante capacité d’autorenouvellement. Ma thèse de doctorat a porté sur l’étude des effecteurs moléculaires impliqués dans la balance entre prolifération et quiescence dans un modèle in vitro de CSK, isolées de manière clonale et définies par le terme holoclone. Je me suis tout d’abord intéressée à la réponse des holoclones à l’effet d’un régulateur important de la prolifération et d

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22

Koeva, Martina I. "Stemness revisited : a meta analysis of stem cell signatures using high-throughput data integration /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2009. http://uclibs.org/PID/11984.

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23

Matsumoto, Yoshiaki. "SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer." Kyoto University, 2018. http://hdl.handle.net/2433/232117.

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24

Grinat, Johanna. "The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22192.

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Genetisch bedingte Veränderungen im Wnt-Signalweg sind in der Tumorigenese des Darms von zentraler Bedeutung. Mutationen des Wnt-Effektormoleküls β-Catenin in den adulten Stammzellen des Darmepithels führen zu unkontrollierter Proliferation und Expansion der Darmstammzellen und initiieren die Tumorentstehung. Auch in fortgeschrittenen Darmtumoren unterstützt die Wnt-Signalgebung maßgeblich das Tumorwachstum und den Erhalt von Tumorstammzellen. Nach erfolgreicher chemotherapeutischer Behandlung treten oftmals Tumorrezidive auf, für deren Entstehung therapieresistente Tumorstammzellen verantwort

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25

Chen, Ru. "Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells." Kyoto University, 2020. http://hdl.handle.net/2433/259015.

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付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第22747号<br>医科博第116号<br>新制||医科||8(附属図書館)<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授長船健二, 教授武藤学, 教授小川誠司<br>学位規則第4条第1項該当

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26

Daiß, Nora [Verfasser]. "Loss of Dkk3 promotes stemness and migration in primary pancreatic cancer cells / Nora Daiß." Ulm : Universität Ulm, 2021. http://d-nb.info/1236993527/34.

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27

BONO, BARTOLO. "Molecular signatures linked to stemness and tumorigenesis in tumorspheres from in vitro transformed cells." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203382.

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28

Tsui, Yu-man, and 徐宇文. "Study of the roles of dishevelled-3 in stemness and cell migration in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196460.

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Hepatocellular carcinoma (HCC) is a common malignancy worldwide and particularly common in China and Southeast Asia. It ranks the 2nd and 4th most common fatal cancer in males and females, respectively, in Hong Kong. Current treatments are not always effective, as recurrence and metastasis in HCC are difficult to tackle and the underlying mechanisms not fully understood. Aberration of Wnt signaling has been implicated in HCC; in this study, we investigated the underlying mechanisms of how aberrant Wnt signaling promoted HCC development. With Taqman Low Density Array (LDA) analysis on 38 pairs

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Beyes, Sven [Verfasser], and Andreas [Akademischer Betreuer] Hecht. "The EMT inducer SNAIL1 deregulates the expression of stemness-associated genes in colorectal cancer cells." Freiburg : Universität, 2018. http://d-nb.info/1237271096/34.

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30

Carter, Lauren. "Defining the Epithelial-to-Mesenchymal Transition and Regulation of Stemness in the Ovarian Surface Epithelium." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38491.

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The ovarian surface epithelium (OSE) is a monolayer of cells surrounding the ovary that is ruptured during ovulation. After ovulation the wound is repaired, however this process, and the mechanisms to maintain OSE homeostasis after the wound is repaired are poorly understood. We have shown the mouse OSE (mOSE) contains a stem cell population that is expanded by Transforming Growth Factor Beta 1 (TGFB1), a factor present in follicular fluid. These data suggest that components in the follicular fluid such as TGFB1 may promote wound repair and OSE homeostasis through maintenance of the OSE stem c

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31

Carlton, Morgan M. "Proteomic characterisation of rat bone marrow-derived mesenchymal stromal cells cultured in 'stemness' promoting conditions." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/117288/1/Morgan_Carlton_Thesis.pdf.

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This thesis investigates the effect of 'stemness' promoting growth conditions on mesenchymal stem cells. A proteomics approach was used to evaluate the biology of the cells and to determine how each of the growth conditions affected cellular differentiation. Several proteins of interest were identified, and their biological roles were assessed.

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Sánchez, Botet Abril. "La ciclina CNTD2: un nuevo inductor del desarrollo tumoral." Doctoral thesis, Universitat Internacional de Catalunya, 2018. http://hdl.handle.net/10803/593163.

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El cáncer colorrectal (CRC) es uno de los cánceres más comunes en todo el mundo, con un 8-10% de estos tumores que presentan una mutación BRAF (V600E). Las ciclinas son oncogenes comúnmente desregulados en muchos cánceres, pero el papel de la nueva subfamilia de ciclinas atípicas no ha sido caracterizada aún. En esta tesis se ha realizado un análisis sistemático de los niveles de expresión de proteínas de seis ciclinas atípicas en tumores de CRC humanos y varias líneas celulares, y encontramos que CNTD2 está significativamente sobreexpresado en los tejidos cancerígenos en comparación con el te

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Zhang, Liyi, and 張麗儀. "Identification and characterization of tumor suppressor gene and cancer stemness gene in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208563.

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Esophageal squamous cell carcinoma (ESCC), the major histological subtype of esophageal cancer, is one of the most common malignancies with poor prognosis in the world. Despite continued development of diagnosis and treatment, ESCC remains the sixth leading cause of cancer death worldwide. Current treatment regimens in ESCC are often characterized by ineffectiveness and poor selectivity. Therapeutic methods directed at cancer-associated genes or cancer stem cells (CSCs) may be effective approaches to cure this deadly cancer. Therefore, this study aims to identify specific ESCC-related genes an

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Asaduzzaman, Muhammad. "Evaluation of drug resistance markers in breast cancers : roles in stemness and epithelial-to-mesenchymal transitions." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/55256.

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There is an urgent need to identify markers of diagnostic and prognostic significance that can help in the development of novel cancer therapeutics. The principal aim of the present study was to evaluate nicastrin and EP300 as potential markers associated with breast cancer drug resistance. Nicastrin is a component of γ-secretase, an intermembrane complex of four proteins with roles in proliferation, cell adhesion and tamoxifen resistance. EP300 is a histone acetyltransferase and a transcriptional activator of E-cadherin which has been shown to regulate epidermal-to-mesenchymal transition and

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Wehling, Carola [Verfasser], and Florian [Akademischer Betreuer] Haasters. "Die Ausschüttung autokriner und parakriner stemness-Faktoren durch humane mesenchymale Stammzellen / Carola Wehling. Betreuer: Florian Haasters." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1099910412/34.

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Grinat, Johanna [Verfasser]. "The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness / Johanna Grinat." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1223452255/34.

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Gräf, Patricia [Verfasser]. "Serial transfer of single cell-derived immunocompetence reveals stemness of CD8+ central memory T cells / Patricia Gräf." München : Verlag Dr. Hut, 2015. http://d-nb.info/1070124389/34.

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Krause, Tamara Manuela [Verfasser], and Roland [Akademischer Betreuer] Kappler. "BCORL1 regulates stemness in hepatoblastoma cells through inhibition of KRT19 expression / Tamara Manuela Krause ; Betreuer: Roland Kappler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221524348/34.

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Ming-JerYoung and 楊明哲. "All-trans-retinoic acid downregulates ALDH1-mediated stemness and search of candidate drugs to target stemness." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/47279037301180932210.

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Li, Hsiang, and 黎享. "Acidic and hypoxic condition on cancer stemness reprogramming." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/57089745574525781424.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>104<br>Lung cancer is the leading cause of cancer-related death around the world. After lots of excursions for advancing the survival, the prognosis of lung cancer remained poor. Recently, cancer stem cells (CSCs) have been identified to be responsible for drug resistance, tumor initiation and metastasis. CSCs can be considered to have the“stemness”property as stem cells with multipotency which maintain self-renewal and differentiate to other cell types. The surrounding microenvironment of CSCs participates in maintaining the stemness of CSCs, and actually the driving

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Chen, Hsin Ying, and 陳心穎. "The Deterministic Role of GRP78 in Cancer Stemness." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/m49y5s.

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Pone, Emanuela. "Stemness and Immunological Features of Thyroid Cancer Cells." Tesi di dottorato, 2017. http://www.fedoa.unina.it/12242/1/thesispone.pdf.

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Cancer stem cells (CSCs) can initiate and maintain tumours and may drive metastasis, recurrence and resistance to anti-neoplastic therapies. Recent evidence suggests that CSCs possess immunomodulatory capabilities that may enable them to evade host anti-cancer immunity to promote tumorigenicity. CSC immunological functions include evasion from immune clearance, induction of clonal anergy or deletion, and activation of regulatory immune cells. We recently identified Interleukin-8 as a crucial factor that sustains the stemness features of thyroid cancer (TC) cells through the induction, among th

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TUSA, IGNAZIA. "Role of ERK5/BMK1 in the survival, proliferation and stemness of chronic myeloid leukemia cells in hypoxia." Doctoral thesis, 2014. http://hdl.handle.net/2158/852106.

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We previously demonstrated that resistance to hypoxia is a common feature of Haematopoietic Stem Cells (HSC) and Leukemic Stem Cells (LSC), but also that a hypoxia-selectable LSC subset is likely to exists within any type of leukemia, including stabilized clonal cells lines. In Chronic Myeloid Leukemia (CML), either cell lines or CD34+ cells explanted from CML patients, hypoxia completely suppresses the expression of BCR/Ablprotein but not that of BCR/Abl transcript, so that hypoxia-resistant cells, while remaining genetically leukemic, are independent of BCR/Abl signaling for their maintenanc

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Chuang, Yi-Han, and 莊逸涵. "The role of Osteoprotegerin in stemness of lung cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/55897018182799517616.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>101<br>Lung cancer is the most common cause of cancer-related mortality worldwide, and the 5-year survival rate is less than 15%. The main reason of high mortality rate is due to the poor prognosis in early-stage lung cancer, the low response rate to chemotherapy and the high recurrence risk after treatment. It has been identified that a small subpopulation of distinct cancer cells (less than 5%), termed cancer stem cells (CSCs), has the abilities to self-renew and differentiate to multiple lineages. CSCs have been supposed to be responsible for chemoresistance,

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Chen, Ting-Chun, and 陳亭均. "Evolution of Stemness and Asymmetric Cell Division in Cancer." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/fsq8n5.

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碩士<br>國立臺灣大學<br>分子與細胞生物學研究所<br>106<br>In the history of life, the appearance of stemness is one of the most remarkable and transformative advances. Experimental evolution approaches have been used to successfully evolve multicellularity in the unicellular budding yeast, Saccharomyces cerevisiae. We reason, given the genome instability of cancer, stemness can also arise from in vitro cancer evolution in the laboratory within a reasonable timescale. We approached the question with a colorectal cancer cell line, HCT116, and used sphere forming as the selective pressure. Sphere-derived cancer stem

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Biagioni, Alessio. "Induction of Stemness Markers in Melanoma Cells by CRISPR/Cas9 uPAR Gene Knockout results in Tumor Growth Inhibition." Doctoral thesis, 2017. http://hdl.handle.net/2158/1076696.

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The CRISPR/Cas9 technology, based on a naturally immune system that protects bacteria and archaea from viral infections is now widely used to manipulate genes in cells and living organisms. This system allowed us to perform a specific gene knockout, hypothetically applicable for treatments of genetic diseases and cancer. Here we have exploited the CRISPR/Cas9 gene knockdown approach to investigate the function of the urokinase plasminogen activator (uPA) receptor (uPAR) in human melanoma and the consequences of its irreversible clearing. uPAR is composed by a three-domains protein and a glycos

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Chen-HsienLiang та 梁鎮顯. "The Role of α-Catulin in Cancer Stemness and Metastasis". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/u6q556.

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博士<br>國立成功大學<br>基礎醫學研究所<br>102<br>Lung cancer is the most common malignant tumors in the world. The high mortality rate in patients with lung cancer is due to cancer metastasis and therapeutic resistance. Many evidences indicate that cancer metastasis and therapeutic resistance are mediated by cancer stem-like cells (CSCs), a small population of cancer cells, which may require for cancer initiation and development. Targeting CSCs may provide effective therapy for human cancers. α-Catulin is an oncoprotein that helps sustain proliferation by preventing cellular senescence. Recent studies have s

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Chen, Wan-Jiun, and 陳菀均. "Cancer-associated fibroblasts regulate the plasticity for lung cancer stemness." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/86386878828410447203.

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博士<br>國立臺灣大學<br>腫瘤醫學研究所<br>102<br>Lung cancer is the leading cause of cancer death in Taiwan and worldwide. After a lot of efforts for improving the survival, the prognosis remained bad. Recently, cancer stem cells (CSCs) theory is proposed for an intrinsic resistance of tumor to chemotherapy. Cancer is regarded as an organ because of hierarchically organized heterogeneous populations of cells and possible originate from its stem cells “cancer stem cells”. CSCs can be viewed to have the ability “stemness” as stem cells with true multipotency and asymmetric division that maintain self-renewal a

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Shih, Pei-Yu, and 石珮妤. "To identify growth factor correlation with stemness of colorectal cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/10257546743406765045.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>101<br>Colorectal cancer incidence rates and mortality rates are ranked third in the world. Recent reports demonstrate that tiny subpopulation of cancer cells, termed cancer stem cells, plays important roles in initiating, maintenance, metastasis, and relapse of tumor. These cells grows in vitro as undifferentiated cancer spheres without serum which is, as previously described, related to metastasis, chemotherapy and radiotherapy resistance. In the past, we enriched cancer spheres from HT29 cells in a defined serum-free medium, with additional bFGF, EGF and N2. In

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Chang, Chih-Hao, and 張智皓. "Matricellular protein CCN1 regulates EMT and stemness of oral cancer." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/37461433045124239873.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>99<br>Oral squamous squamous cell carcinoma ( OSCC ) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic oral cancer stem-like cells ( OC-SLCs ) from OSCC. However, the molecular mechanisms by which to govern the characteristics in OC-SLCs remain unclear. Cysteine-rich 61 ( CCN1 ), a matricellular protein that has disparate function dependent on cell type-specific manner, is closely related to multiple cellular function. In oral squamous cell carcinoma, it had been identified tha

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