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Dissertations / Theses on the topic 'Stenosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Johansson, Elias. "Carotid stenosis." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46396.

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Carotid stenosis is one of several causes of ischemic stroke and entails a high risk of ischemic stroke recurrence. Removal of a carotid stenosis by carotid endarterectomy results in a risk reduction for ischemic stroke, but the magnitude of risk reduction depends on several factors. If the delay between the last symptom and carotid endarterectomy is less than 2 weeks, the absolute risk reduction is >10%, regardless of age, sex, or if the degree of carotid stenosis is 50–69% or 70–99%. Thus, speed is the key. However, if many patients suffers an ischemic stroke recurrence within the first 2
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2

Lee, Paul Man-Yiu. "Critical coronary stenosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq23948.pdf.

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3

Eklöf, Hampus. "On Renal Artery Stenosis." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5945.

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<p>Renal artery stenosis (RAS) is a potentially curable cause of hypertension and azotemia. Besides intra-arterial renal angiography there are several non-invasive techniques utilized to diagnose patients with suspicion of renal artery stenosis. Removing the stenosis by revascularization to restore unobstructed blood flow to the kidney is known to improve and even cure hypertension/azotemia, but is associated with a significant complication rate. </p><p>To visualize renal arteries with x-ray techniques a contrast medium must be used. In a randomized, prospective study the complications of two
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4

Kragsterman, Björn. "Carotid Artery Stenosis : Surgical Aspects." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6834.

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<p>Randomised controlled trials (RCT) have demonstrated a net benefit of carotid endarterectomy (CEA) in stroke prevention for patients with severe carotid artery stenosis as compared to best medical treatment. Results in routine clinical practice must not be inferior to those in the RCTs. The carotid arteries are clamped during CEA which may impair the cerebral perfusion. </p><p>The aim of this thesis was to assess population-based outcomes from CEA, investigate risk factors for perioperative complications/late mortality and to evaluate effects of carotid clamping during CEA. In the Swedish v
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5

Kragsterman, Björn. "Carotid artery stenosis : surgical aspects /." Uppsala : Acta Universitatis Upsaliensis : Univ.bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6834.

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6

McCann, Gerald Patrick. "Exercise limitation in aortic stenosis." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395082.

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7

Pawade, Tania Ashwinikumar. "Imaging calcification in aortic stenosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29589.

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BACKGROUND Aortic stenosis is a common and potentially fatal condition in which fibro-calcific changes within the valve leaflets lead to the obstruction of blood flow. Severe symptomatic stenosis is an indication for aortic valve replacement and timely referral is essential to prevent adverse clinical events. Calcification is believed to represent the central process driving disease progression. 18F-Fluoride positron emission tomography computed tomography (PET-CT) and CT aortic valve calcium scoring (CT-AVC) quantify calcification activity and burden respectively. The overarching aim of this
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8

Boyd, C. S. "Radiological evaluation of renal artery stenosis." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426973.

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9

Kattach, Hassan. "Blood pressure control in aortic stenosis." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526473.

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10

Försth, Peter. "On Surgery for Lumbar Spinal Stenosis." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262525.

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The incidence of lumbar spinal stenosis (LSS) is steadily rising, mostly because of a noticeably older age structure. In Sweden, LSS surgery has increased continuously over the years and is presently the most common argument to undergo spine surgery. The purpose of the surgery is to decompress the neural elements in the stenotic spinal canal. To avoid instability, there has been a tradition to do the decompression with a complementary fusion, especially if degenerative spondylolisthesis is present preoperatively. The overall aims of this thesis were to evaluate which method of surgery that gen
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11

Sandhu, G. S. "Management of adult benign laryngotracheal stenosis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324556/.

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Upper airway stenosis has a significant impact on the quality of life and sometimes on life itself. The incidence of this condition is likely to be increasing as survival rates following periods of ventilation on Intensive Care Units (ICUs) improve (1, 2). Paediatric laryngotracheal stenosis is a well researched discipline and treatment includes airway augmentation with rib grafts and tracheal or cricotracheal resection with end-to-end anastomosis. At the start of my research, in 2005, adult laryngotracheal stenosis was poorly researched and the treatment options were tracheostomy, tracheal re
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12

Shalhoub, Joseph. "Risk stratification in atherosclerotic cartoid stenosis." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9063.

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Introduction: Key trials and a Cochrane systematic review in asymptomatic carotid stenosis have highlighted the need to identify a high-risk subgroup of patients with carotid stenosis who may benefit from intervention. Traditionally, this risk stratification has considered structural imaging and clinical factors. However, using only these approaches, still a significant number of patients are missed. Biological attributes are acknowledged as key determinants of thrombo-embolic events. Functional and hybrid structural-functional imaging, and circulating biomarkers allow exploration of plaque bi
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13

Ihlberg, Leo. "Surveillance for infrainguinal vein graft stenosis." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/ihlberg/.

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14

Anderson, David Barrett. "Optimising Management of Lumbar Spinal Stenosis." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25075.

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Low back pain is the leading cause of disease burden globally, impacting over half a billion people. Low back pain is a broad classification of a condition which includes multiple clinical presentations, such as spondylosis, discogenic pain, muscle and ligament injuries, and lumbar spinal stenosis (LSS). This thesis has focused on LSS, which itself is a leading cause of pain, disability, and reduced quality of life among older adults. Eight chapters are included in this thesis that aims to improve the management of LSS. Chapter One was an introduction to LSS, its diagnosis, prevalence, and
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15

Cowell, Sarah Joanna. "Lipid-lowering therapy in calcific aortic stenosis." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/29075.

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We hypothesised that (a) risk factors for atherosclerosis would predict, and (b) lipid lowering therapy would retard, disease progression and clinical outcome in patients with calcific aortic stenosis. Objectives: In patients with aortic stenosis, (i) to compare the magnitude and reproducibility of measures of valvular stenosis and calcification, (ii) to determine the effect of intensive lipid lowering therapy on disease progression and clinical outcome, and (iii) to describe predictors of disease progression and clinical outcome. Methods: In the Scottish Aortic stenosis and Lipid lowering The
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16

Simons, Dianne Margaret. "The hydrodynamics of idiopathic hypertrophic subaortic stenosis." Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/10257.

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17

Das, Paul Kumar. "Prediction of symptom onset in aortic stenosis." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414771.

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18

Cheshire, Nicholas John. "Risk factors in infra-inguinal graft stenosis." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34301.

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Intimal hyperplasia appears to be the universal vessel response to injury and is important in atherogenesis. In animal and in-vitro models, the initiation and promotion of this process has been associated with a number of risk factors found in the circulation. In man, approximately 25% of infrainguinal bypass grafts develop stenosis due to smooth muscle cell proliferation but it is not known if circulating risk factors influence this process. In these studies, circulating risk factors have been correlated with the development of hyperplastic stenoses in infrainguinal bypass grafts. Non-hyperpl
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19

Izeki, Masanori. "Reduction of Atlantoaxial Subluxation Causes Airway Stenosis." Kyoto University, 2014. http://hdl.handle.net/2433/185188.

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20

Bull, Sacha Colette. "Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce.

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The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk that irreversible myocardial damage may occur with a conservative management strategy. It has become increasingly apparent that prognosis in asymptomatic AS depends not only on the degree of valvular stenosis, but also on the myocardial response to pressure overload and understanding the mechanisms of myocardial decompensation may help to guide management in the future. The degree of myocardial fibrosis, microvascular dysfunction, h
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21

Jönsson, Anders. "Surgical treatment of left main coronary artery stenosis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-736-7/.

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22

Jansson, Karl-Åke. "On lumbar spinal stenosis and disc herniation surgery /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-257-8/.

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23

Bouma, Berto Jorrit. "Clinical decision making in elderly with aortic stenosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/78202.

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24

Shrum, Jeff. "Platelet adhesion in an asymmetric stenosis flow model." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100235.

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Platelets have been shown to be a main contributor to thrombus formation in stenotic arteries leading to acute coronary syndromes. It is thought that increased activation and adhesion of platelets under variable shear and complex flow conditions contribute to thrombosis. The objective of this work was to evaluate the relationship between asymmetric stenosis hemodynamics and platelet adhesion using in-vitro models developed to properly simulate physiological conditions. In this study, platelet rich plasma was circulated through stenotic and straight coronary artery models. Adhesion results were
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25

Barkhordarian, Reza. "Subaortic stenosis in hearts with intact ventricular septum." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511290.

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26

Chen, Lijia. "Rapid angiographic stenosis progression : systematic and local factors." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299283.

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27

Georgoula, C. "Molecular genetic analysis of infantile hypertrohpic pyloric stenosis." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/16124/.

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The aim of this study was to identify susceptibility genes for the common disease Infantile Hypertrophic Pyloric Stenosis (IHPS) using a whole genome screening approach. IHPS is a form of gastrointestinal obstruction with an incidence between 1 and 5 per 1000 live births. It is characterized by hypertrophy of the pyloric smooth muscle, which develops after birth in response to enteral feeds and leads to gastric outlet obstruction with projectile vomiting. IHPS is commonly inherited as a multifactorial trait with a marked male preponderance but monogenic and syndromic forms are also described.
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28

Porter, R. W. "Spinal stenosis and disorders of the lumbar spine." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22563.

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This is a submission of 57 publications on the subject of "Spinal stenosis and disorders of the lumbar spine". It describes work personally carried out or personally supervised, between 1978 and 1997. 30 publications describe studies of spinal stenosis. <i>The development of the vertebral canal</i> is investigated from archaeological material, foetal collections and by the studies of volunteers. Intrauterine factors are identified which influence the canal's size and shape. Epidemiological studies are presented which have measured the canal in large numbers of volunteer adults and children, an
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29

Sen, Sayan. "Assessment of intra-coronary pressure and flow velocity relations distal to coronary stenoses to derive a novel index of stenosis severity." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25062.

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The optimal treatment for patients with stable angina remains controversial. Coronary angioplasty is increasingly performed in stable patients to reduce symptoms. Over the last 20 years there has been an accumulation of data demonstrating that an objective physiological approach to revasularisation is superior to the tradional angiographic approach. Several intra-coronary indices of stenosis severity have been proposed using pressure alone, flow velocity alone or a combination of both pressure and flow velocity. The most clinically used index, Fractional Flow Reserve (FFR) uses pressure alone
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30

Peltonen, T. (Tuomas). "Endothelial factors in the pathogenesis of aortic valve stenosis." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289880.

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Abstract Calcified aortic valve disease represents a spectrum of disease spanning from mild aortic valve sclerosis to severe aortic valve stenosis (AS), being an actively regulated disease process and showing some hallmarks of atherosclerosis. The calcified aortic valve lesion develops endothelial injury and is characterized by inflammation, lipid accumulation, renin-angiotensin system activation and fibrosis. There is no approved pharmacological treatment available in AS. This study was aimed to characterize gene expression of endothelial factors in aortic valves in patients representing
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31

Crawley, F. A. M. "Carotid artery stenosis : the role of angioplasty and surgery." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598140.

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32

Dionisio, Kathie L. (Kathie Lynn). "Ex-vivo 3D assessment of carotid stenosis with ultrasound." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32364.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.<br>Includes bibliographical references (p. 71-74).<br>Atherosclerosis causes heterogeneous remodeling of arterial structure and composition in the carotid vessel wall. It has been shown that the progression of the disease can be monitored by tracking changes in the carotid intima-media thickness (IMT). Non-invasive peripheral vascular ultrasound (U/S) of the carotid artery is a non-invasive, cost effective, accepted means of measuring IMT. Traditionally, evaluation of IMT in the carotid has been limite
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33

Rask, Peter. "Aortic stenosis : diagnostic use and hemodynamic effects of dipyridamole." Doctoral thesis, Umeå universitet, Klinisk fysiologi, 1995. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118692.

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34

Roberts, Elved Bryn. "Assessment of coronary artery stenosis using myocardial contrast echocardiography." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1445931/.

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The theoretical advantage of perfusion data over wall motion data for diagnosing coronary artery stenosis relates to the temporal sequence of these phenomena in the ischaemic cascade. Myocardial perfusion evaluation could thus provide earlier information than wall motion assessment, with important clinical consequences. This thesis examines myocardial perfusion assessment using ultrasound and micro-bubble contrast in stable coronary artery stenosis. The first set of experiments were undertaken to establish both a means of infusing Optison (GE Healthcare, UK), and of displaying static frame con
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35

Broyd, Christopher. "Coronary haemodynamics and wave intensity analysis in aortic stenosis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/23961.

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Introduction: Coronary Wave Intensity Analysis (WIA) provides an invasive measure of energy transfer within the coronary circulation. I set out to derive a non-invasive measure of the backward expansion wave (BEW) responsible for coronary flow and assess it during exercise and in aortic stenosis (AS). Methods: 17 patients (mean age 60, 11 male) with normal cardiac function underwent invasive LAD WIA calculation using a pressure- and flow-tipped wire. Non-invasive WIA was calculated immediately after angiography from simultaneous PW Doppler of the LAD and a suprasystolic-cuff derived measure of
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36

Akherat, S. M. Javid Mahmoudzadeh. "Development of a predictne framework to forecast venous stenosis." Thesis, Illinois Institute of Technology, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10243926.

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<p> The end stage renal disease (ESRD) patient population is growing at a troubling rate, calling for a focused attention to investigate the chronic kidney diseases, their characteristics and our lines of defense against them. One major medical treatment for ESRD patients is hemodialysis which is facilitated through vascular access (VA). The vascular access of particular interest in this investigation as well as the med- ical community is the brachiocephalic fistula (BCF), which is a form of arteriovenous fistula (AVF), created surgically by connecting the brachial artery and the cephalic vein
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37

Korpela, Antti. "Healing of airway anastomoses and stenting of airway stenosis." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/korpela/.

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38

MOSCHETTA, DONATO. "UNRAVELLING SEX-DEPENDENT MECHANISMS IN CALCIFIC AORTIC VALVE STENOSIS." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/947275.

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Calcific aortic valve stenosis (CAVS) is the most common form of heart valve disease and affects about 3% of the population. Its prevalence increases with age, without a causal relation between ageing and CAVS development. To date, CAVS is a slow, progressive, multifactorial disorder considered to be actively driven by several cellular and molecular processes. Its natural history consists of a long clinically silent phase of non-uniform leaflet thickening with or without minimal calcification, known as aortic valve sclerosis (AVSc), without significant obstruction of blood flow, followed by th
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39

Seale, Anna Nancy. "Pulmonary vein stenosis : a population-based study of total anomalous pulmonary venous connection and the impact of pulmonary vein stenosis and a study of congenital pulmonary vein stenosis : the United Kingdom, Ireland and Sweden collaborative study." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607643.

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40

Zhao, Ying. "Effect of valve replacement for aortic stenosis on ventricular function." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46809.

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Background：Aortic stenosis (AS) is the commonest valve disease in the West. Aortic valve replacement (AVR) remains the only available management for AS and results in improved symptoms and recovery of ventricular functions. In addition, it is well known that AVR results in disruption of LV function mainly in the form of reversal of septal motion as well as depression of right ventricular (RV) systolic function. The aim of this thesis was to study, in detail, the early and mid-term response of ventricular function to AVR procedures (surgical and TAVI) as well as post operative patients’ exercis
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41

Refson, Jonathan Simon. "Vein graft stenosis and the human vascular smooth muscle cell." Thesis, Imperial College London, 2000. http://hdl.handle.net/10044/1/7763.

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42

Nouraei, Seyed Ahmad Reza. "An investigation of the surgical physiology of adult laryngotracheal stenosis." Thesis, University of Bath, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616576.

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Abnormal narrowing of the larynx, trachea, or bronchi, -Laryngotracheal Stenosis- increases airflow resistance and manifests as exertional dyspnoea, stridor, and effort intolerance. This clinical presentation is very similar to those of lower airway diseases. It is common therefore for this rare condition to be misdiagnosed and incorrectly managed. I addressed this potentially fatal diagnostic shortcoming by developing a simple physiological index, derived from routine spirometry data of approximately 10,000 patients, that can reliably diagnosis laryngotracheal stenosis. Undertaking shared-air
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43

Teien, Dag. "Assessment of aortic stenosis with special reference to Doppler ultrasound." Doctoral thesis, Umeå universitet, Klinisk fysiologi, 1986. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103813.

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44

Knutsson, Björn. "Lumbar spinal stenosis : Body mass index and the patient's perspective." Doctoral thesis, Uppsala universitet, Ortopedi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264589.

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During recent decades, lumbar spinal stenosis (LSS) has become the most common indication for spine surgery, a change that coincides with a higher worldwide prevalence of overweight and obesity. Thus, surgical treatment of LSS in the overweight and obese population is common and increasing in scope. The overall aim of this thesis was to investigate whether body mass index (BMI) is related to the development of LSS, and whether BMI is linked to outcome after surgery for LSS. We further evaluated whether there are specific experiences of LSS from a patient perspective. Data were obtained for all
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45

Garoff, Maria. "Carotid calcifications in panoramic radiographs in relation to carotid stenosis." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119794.

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Calcifications in carotid atheromas can be detected in a panoramic radiograph (PR) of the jaws. A carotid artery calcification (CAC) can indicate presence of significant (≥ 50%) carotid stenosis (SCS). The aim of this thesis was to (1) determine the prevalence of SCS and burden of atherosclerotic disease among patients revealing CACs in PRs, (2) determine the prevalence of CACs in PRs among patients with SCS, (3) analyze whether the amount of calcium and/or (4) the radiographic appearance of the CACs, can improve the positive predictive value (PPV) for SCS detection among patients with CACs in
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46

Dweck, Marc Richard Leslie. "Assessment of aortic stenosis using modern non-invasive imaging techniques." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8136.

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Introduction. Aortic stenosis is characterised both by progressive narrowing of the valve and the hypertrophic response of the left ventricle. The purpose of this thesis was to study the contribution of inflammation and calcification to valve narrowing using Positron Emission and Computed Tomography (PET/CT) and to investigate the hypertrophic response using cardiovascular magnetic resonance (CMR). Methods. PET/CT studies. Patients with aortic sclerosis and mild, moderate and severe stenosis were prospectively compared to matched control subjects. Aortic valve severity was determined by echoca
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47

Konala, Bhaskar Chandra. "Effect of Arterial Wall-Stenosis Compliance on Coronary Diagnostic Parameters." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291146768.

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48

Clark, Elizabeth. "Models and Mechanisms to Evaluate Tissue Engineered Vascular Graft Stenosis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492735573118956.

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49

Anderson, Kailyn M. "Noonan Syndrome Spectrum Disorders in Patients with Valvar Pulmonary Stenosis." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1495807026761869.

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50

Treibel, Thomas Alexander. "Aortic stenosis : a myocardial disease : insights from myocardial tissue characterisation." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1574742/.

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Aortic stenosis (AS) is a disease of not just the valve, but also of the myocardium. Patient symptoms and outcome are determined by the myocardial response; a crucial but poorly understood process. Diffuse and focal myocardial fibrosis play a key role. Until recently, both could only be assessed using invasive histology, but now cardiovascular magnetic resonance (CMR) offers late gadolinium enhancement (LGE) and extracellular volume fraction (ECV) techniques. In this thesis, I developed new methods to quantify ECV by synthetic ECV and cardiac CT. I then explored myocardial remodelling and fibr
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