Journal articles on the topic 'Stephanie Maria'

Hellmut Flashar: Hippokrates. Meister der Heilkunst (Michaela Rücker) Manfred Clauss: Athanasius der Große. Der unbeugsame Heilige (Peter Antes) Johannes Willms: Mirabeau oder die Morgenröte der Revolution. Eine Biografie (Hans-Christof Kraus) Stephanie Velten: Johann Julius Wilhelm Ritter von Planck. Leben und Werk (Dirk Blasius) Katharina Abermeth: Heinrich Schnee. Karriereweg und Erfahrungswelten eines deutschen Kolonialbeamten (Ulrich van der Heyden) Marianna Butenschön: Die Hessin auf dem Zarenthron. Maria. Kaiserin von Russland (Martin Malek) Henrik Meinander: Gustaf Mannerheim. Aristokrat i vadmal. [Gustaf Mannerheim. Aristokrat in Loden] (Michael Peters) Hubert Kiesewetter: Karl Marx und der Untergang des Kapitalismus (Ludger Heid) Jürgen Neffe: Marx. Der Unvollendete (Ludger Heid) Alexander Sperk, Daniel Bohse: Legende, Opportunist, Selbstdarsteller. Felix Graf Luckner und seine Zeit in Halle/Saale (1919-1945) (Wolfgang Kaufmann) Frederick Bacher: Friedrich Naumann und sein Kreis (Hans-Christof Kraus) Werner Plumpe: Carl Duisberg (1861-1935). Anatomie eines Industriellen (Werner Bührer) Olaf Jessen: Die Moltkes. Biografie einer Familie (Heinrich Walle) Wilhelm Hartmut Pantenius: Alfred Graf von Schlieffen. Stratege zwischen Befreiungskriegen und Stahlgewittern (Hans-Christof Kraus) Ingrid Wölk: Leo Baer. 100 Jahre deutsch jüdische Geschichte. Mit „Erinnerungssplittern eines deutschen Juden an zwei Weltkriege“ (Ludger Heid) Meike Hoffmann, Nicola Kühn: Hitlers Kunsthändler. Hildebrand Gurlitt (1895-1956). Die Biografie (Wolfgang Kaufmann) Victor Klemperer: Warum soll man nicht auf bessere Zeiten hoffen. Ein Leben in Briefen (Ludger Heid) Magnus Brechtken: Albert Speer. Eine deutsche Karriere (Ludger Tewes) Bernd Bonwetsch: Mit und ohne Russland. Eine familiengeschichtliche Spurensuche (Karl-Heinz Schlarp) Christoph Marx: Mugabe. Ein afrikanischer Tyrann (Ulrich van der Heyden)

Este artigo traz uma atividade de leitura para Histórias da Velha Totônia, de José Lins do Rego, um guardião da memória e da tradição do seu tempo de infância e juventude. O objetivo deste trabalho é mostrar como a carga simbólica e significativa que envolve essa obra pode ser explorada na escola, numa turma de 7º ano do Ensino Fundamental, quando associada ao trabalho com o ensino da compreensão leitora. Evidencia-se como, a partir dessa obra da literatura infantojuvenil, que destaca a contação de histórias, é possível acionar o conhecimento prévio para estabelecer conexões, fazer inferências, sumarizar e sintetizar para compreender as quatro aventuras contadas pela Velha Totônia. A contação de histórias desperta o interesse pela leitura e contribui para a formação de leitores proficientes. Dentro da temática dos clássicos, as histórias da Velha Totônia são ambientadas no Nordeste brasileiro. Por envolver aspectos da constituição social de um povo, a leitura consiste em um instrumento constituidor de subjetividades e da formação inteligível de um ser. Por isso, essa proposta une contação de histórias e estratégias de compreensão leitora. Apresenta uma prática de leitura que, não só facilita, mas também viabiliza o processo de compreensão integral das histórias da boa velhinha, que saía pelos engenhos contando histórias de Trancoso. Compreender e interpretar os diversos tipos de textos, a partir de diferentes finalidades contribui de forma significativa para o desenvolvimento potencial das pessoas e sua atuação numa sociedade letrada.Recebido em: 06-05-2020Revisões requeridas em: 28-07-2020Aceito em: 04-08-2020REFERÊNCIAS:BAKHTIN, Mikhail. Questões de literatura e estética: a teoria do romance. São Paulo: Hucitec, 2014.BOSI, Alfredo. História concisa da literatura brasileira. São Paulo: Cultrix, 2013.BOSI, Ecléa. MEMÓRIA E SOCIEDADE: lembranças de velhos. São Paulo: T. A. Quelroz, Editor, LTOA. Universidade de São Paulo, 1979. Disponível em https://edisciplinas.usp.br/pluginfile.php/4214438/mod_resource/content/1/BOSI%2C%20E.%20Mem%C3%B3ria%20e%20sociedade.%20Introdu%C3%A7%C3%A3o.pdf.CARPEAUX, Otto Maria. Pequena bibliografia crítica da literatura brasileira. Ministério da Educação: Serviço de Documentação, 1951. Disponível em: https://kupdf.net/download/carpeaux-otto-pequena-bibliografia-critica-da-literatura-brasileirapdf_5a5e4835e2b6f53a67e6f051_pdf. DALCASTAGNÈ, Regina. Literatura brasileira contemporânea: um território contestado. Horizontes: São Paulo, 2018.DALVI, Maria Amélia. Literatura na educação básica: propostas, concepções, práticas. Cadernos de Pesquisa em Educação – PPGE/UFES, Vitória, ES. a. 10, v. 19, n. 38, p. 11-34, jul./dez. 2013.DAVIS, Lynn e SOUZA, Renata Junqueira. Entendendo textos: estratégias para a sala de aula. Leitura. Teoria Prática, 2009. v. 1, p. 31-37.FISCHER, Luis Augusto. Literatura brasileira: modos de usar. Porto Alegre: LPM, 2007.FRANCHETTI, Paulo. Estudos de literatura brasileira e portuguesa. São Paulo: Ateliê Editorial, 2007.HARVEY, Stephanie; GOUDVIS, Anne. Strategies that work. Teaching comprehension for undderstanding and engagement. USA: Stenhouse Publishers Pembroke Publishers, 2008.MOISÉS, Massaud. A literatura brasileira através dos textos. São Paulo: Cultrix, 2012.PRESSLEY, Michael. Reading instruction that works: The case for balanced teaching, 2nd edition. New York: Guilford, 2002.REGO, José Lins do. Histórias da velha Totônia. Rio de Janeiro: Ed. José Olympio, 2010.SANTOS, Ana Maria Martins da Costa e SOUZA, Renata Junqueira de. Andersen e as estratégias de leitura. Campinas-SP: Mercado de Letras, 2011.SANTOS, Luciene Souza; ARAPIRACA,Mary de Andrade. Testamento das gentes das maravilhas. Revista EntreIdeias. Vol. 6, n. 2 (jan./jun. 2017). Salvador: Universidade Federal da Bahia, Faculdade de Educação, 2017. Disponível em file:///C:/Users/Cliente/Desktop/21675-84608-1-PB.pdf.SOLÉ, I. Estratégias de leitura. Porto alegre: Artes médicas, 1998.ZILBERMAN, Regina. A leitura e o ensino da literatura. São Paulo: Contexto, 1988.ZIMMERMANN, Susan; HUTCHINS, Chryse. 7 keys to comprehension: how to help your kids read it and get it! Portsmouth NH: Three Rivers Press, 2003.

The name resource of Lemkos living in the first half of the nineteenth century is mostly made up of anthroponyms derived from the Christian tradition, i.e. biblical names, as well as names of the holy martyrs and the blessed of different periods of Christianity, belonging more often to Eastern Churches, a little less often to the Catholic Church. Most of the Lemko anthroponyms derive from the Orthodox-Russian tradition, which in turn has its roots in the Greek tradition. Names of Greek etymology account for 50.5% of the excerpted material. The most common ones include the following: Anastasia, Gregor, Basilius, Andreas, Stephanus, Theodorus, Ksenia, Parasceve, Pelagia, Demetrius, Petrus, Helena. Latin names are much less common (19%), e.g. Paulus, Romanus, Antonius, Ignatius, Julia, Julianus, as well as Hebrew names (12,4%), e,g. Maria, Anna, Ewa, Joannes, Symeon. Germanic names (Wilhelmus, Adalbertus, Conradus, Leopoldus) and Slavic names (Stanislaus) were among the rarest. The analyzed anthroponomastics is characterized by high repeatability of names. The proper names in the top ten make up 57.3% of all units. The most frequently repeated names are Maria, Joannes, Anna, Anastasia, Gregorius, Andreas, Theodorus, Stephanus, Simeon. Names which have appeared once represent only 2.3% of the analyzed anthroponomastics.

We describe the adult, egg, and all larval stages of a new geometrid moth, Kunanyia stephaniae gen. nov. and sp. nov. Although the genus can be placed in the tribe Nacophorini on key morphological features, it possesses a unique suite of characters that distinguish it from other described nacophorines. Larvae reared from eggs obtained from field-collected females, survived to maturity feeding on the dead leaves of Eucalyptus coccifera and other Eucalyptus spp, an unusual foodplant for Geometridae. To date, adults have only been collected in montane habitats on Mt Wellington near Hobart and Mt Bishop and Clerk, Maria Island, Tasmania.

Gegenspiel, o romance que o escritor alemão Stephan Thome publicou em 2015, tem a particularidade de apresentar aos leitores o mesmo universo diegético do seu romance anterior, Fliehkräfte (2012). Com efeito, as duas obras narram o casamento de Hartmut Hainbach – Professor de Filosofia na universidade de Bona – com a portuguesa Maria – que fora estudar Teatro para Berlim, na década de 80 –, centrando-se especialmente na crise em que a relação se encontra ao fim de vinte anos. A acção é, portanto, já conhecida, mas existe uma diferença importante: enquanto Fliehkräfte contava a história do ponto de vista de Hartmut, Gegenspiel mostra-a do ponto de vista de Maria. O presente estudo adopta uma orientação fundamentalmente intercultural e aborda a identidade híbrida da personagem de Maria para a apresentar como figura refl ectora tanto da contemporaneidade alemã como da portuguesa.

Biskup Stefan Wyszyński: lubelski okres posługi pasterskiej (1946–1949) Dnia 4 marca 1946 r. watykańska Kongregacja do Spraw Nadzwyczajnych, zajmująca się wówczas nominacjami biskupimi, przesłała do biura Prymasa Polski, kardynała Augusta Hlonda, dokument informujący o mianowaniu przez papieża Piusa XII pierwszych po wojnie biskupów polskich, a wśród nich także nowego biskupa lubelskiego, księdza Stefana Wyszyńskiego: „Beatissimus Pater promovit Reverendum D. Stephanum Wyszyński e clero vladislaviensi ad Ecclesiam Cathedralem Lublinensem. Eadem Sanctitas Sua concedit dicto Electo Stephano Wyszyński indultum recipiendi conssecrationem episcopalem necnon capiendae possessionis dioecesis Lublinensis priusqam ad eum Bullae Apostolicae pervenerint”. W tym czasie biskup nominat miał mniej niż 45 lat. Pomimo tego, w dość krótkim okresie swoich rządów (2 lata i 8 miesięcy), biskup Wyszyński dokonał wielkiego dzieła. Przede wszystkim zapoczątkował odnowę i odbudowę diecezji ze zniszczeń wojennych i wprowadził ją na nowe drogi rozwoju. Niewątpliwie był to czas, który można określić mianem wielkiego zrywu i odrodzenia Kościoła w Polsce. Powyższy artykuł ukazuje jak nominacja biskupia, jak też ingres do katedry lubelskiej otworzyły przed biskupem Wyszyńskim nowe perspektywy działań i wyznaczały kolejne zadania w ramach pasterskiego posługiwania Kościołowi w Polsce i na świecie. Co więcej – zdaniem autora niniejszego studium – ponad dwa i pół roku posługi w diecezji lubelskiej było też – swego rodzaju – poligonem doświadczalnym, gdzie biskup Wyszyński mógł wykorzystać, jak również rozwinąć doświadczenia duszpasterskie zdobyte wcześniej we Włocławku. Był to jednocześnie kolejny etap przygotowywania do podjęcia już wkrótce najważniejszych zadań w Kościele. Innymi słowy, lubelski okres posługi pasterskiej biskupa Wyszyńskiego okazał się niezmiernie cennym doświadczeniem w perspektywie późniejszej działalności jako ordynariusza diecezji gnieźnieńskiej i warszawskiej oraz Prymasa Polski.

The study of nonviolent civil resistance is now in vogue. The American Political Science Association gave its best book award this year to Erica Chenoweth and Maria Stephan, authors of Why Civil Resistance Works: The Strategic Logic of Nonviolent Conflict. Additionally, in the last few years, there have been an unprecedented number of academic books, edited volumes, and journal special issues published on this topic, largely due to interest generated by the Arab Spring uprisings and the “color revolutions” in post-communist regions.

Background:Baricitinib (BARI), an oral, selective Janus kinase (JAK)1 and JAK2 inhibitor, improved disease severity in adults with systemic lupus erythematosus (SLE) receiving standard background therapy in a phase 2 trial1. There were no meaningful reductions in least squares mean change from baseline (BL) in levels of serologic biomarkers for SLE with BARI treatment, including anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibodies and complement component (C)3 and C41.Objectives:Evaluate the median change from BL in serologic biomarkers in subgroups and the overall population of BARI-treated SLE patients, in addition to the Systemic Lupus Erythematosus Responder Index-4 (SRI-4) response by normalization of anti-dsDNA.Methods:Data were assessed from the phase 2 trial JAHH (NCT02708095). The median change from BL in anti-dsDNA, IgG, C3, and C4 was evaluated over time among the following populations at BL: anti-dsDNA positive (≥30 IU/mL), low C3 (<90 mg/dL), low C4 (<10 mg/dL), and all patients for IgG. Statistical tests were conducted for BARI 2-mg and 4-mg compared with placebo (PBO). Among patients who were anti-dsDNA positive at BL, SRI-4 responder rate was compared for those who stayed positive or achieved normal levels by Week (Wk) 24.Results:Among patients who were anti-dsDNA positive at BL, significant decreases of anti-dsDNA antibodies were observed for BARI 2-mg and 4-mg compared to PBO beginning at Wks 2 and 4, respectively, and continuing through Wk 24 (Figure 1 and Table 1). Moreover, reductions of IgG levels were found for BARI-treated patients including significant decreases for BARI 4-mg compared to PBO at Wks 12 and 24 (Table 1). Among patients who had low levels of C3 and C4 at BL, no significant differences in median change from BL were observed over time with BARI compared to PBO. For patients who were anti-dsDNA positive at BL, no relationship in SRI-4 responder rate was observed for those who stayed positive or achieved normal levels by Wk 24, possibly due to the limited sample size.Conclusion:BARI treatment resulted in a rapid and sustained significant decrease in anti-dsDNA antibodies compared to PBO among anti-dsDNA positive SLE patients at BL, as well as a significant decrease in IgG levels in the 4-mg group at Wks 12 and 24. These data suggest that BARI may have an effect on B cell activity in SLE.References:[1]Wallace D et al. Lancet. 2018;392:222-231.Table 1.PBOBARI 2-mgBARI 4-mgWeek412244122441224Anti-dsDNA (IU/mL)a0.2 (-17.2, 17.3)2.6 (-14.8, 18.4)3.0 (-14.9, 28.3)-15.4** (-31.4, 1.9)-18.1* (-42.0, 4.1)-29.6** (-55.1, 10.3)-17.9** (-42.7, 1.8)-23.3*** (-50.9, -5.9)-15.1** (-71.9, -4.6)IgG (g/L)b-0.31 (-1.1, 0.4)0.09 (-1.1, 0.7)-0.04 (-0.9, 0.9)-0.60 (-1.3, 0.6)-0.30 (-1.3, 0.4)-0.51 (-1.7, 0.6)-0.56 (-1.2, 0.2)-0.65** (-1.3, 0.2)-0.60** (-1.7, 0.2)Data are median change from baseline (25th, 75th percentiles). aData were assessed for patients that were anti-dsDNA positive (≥30 IU/mL) at baseline (PBO N=51, BARI 2-mg N=56, BARI 4-mg N=53). bData were assessed for all patients (PBO N=105, BARI 2-mg N=105, BARI 4-mg N=104). *p≤0.05, **p≤0.01, ***p≤0.001 for BARI vs. PBO.Acknowledgements:The authors would like to acknowledge Nicole L. Byers, of Eli Lilly and Company, for medical writing and process support.Disclosure of Interests:Thomas Dörner Speakers bureau: Eli Lilly and Company, Roche, and Samsung, Consultant of: AbbVie, Celgene, Eli Lilly and Company, Janssen, Novartis, Roche, Samsung, and UCB, Grant/research support from: Janssen, Novartis, Roche, Sanofi, and UCB, Ronald van Vollenhoven Consultant of: Abbvie, Biotest, BMS, Celgene, Crescendo, Eli Lilly and Company, GSK, Janssen, Merck, Novartis, Pfizer, Roche, UCB, and Vertex, Grant/research support from: Abbvie, Amgen, BMS, GSK, Pfizer, Roche, and UCB, Andrea Doria Speakers bureau: GSK, Janssen, Pfizer, and Roche, Consultant of: Celgene, Eli Lilly and Company, and GSK, Bochao Jia Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Damiano Fantini Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Jorge Ross Terres Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Maria Silk Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Stephanie de Bono Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Peter Fischer Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Daniel J. Wallace Consultant of: Amgen, Aurunia, Eli Lilly and Company, EMD Merck Serono, GSK, and Pfizer

Background:An increased risk of severe COVID-19 outcomes may be seen in patients with autoimmune diseases on moderate to high daily doses of glucocorticoids, as well as in those with comorbidities. However, specific information about COVID-19 outcomes in SLE is scarce.Objectives:To determine the characteristics associated with severe COVID-19 outcomes in a multi-national cross-sectional registry of COVID-19 patients with SLE.Methods:SLE adult patients from a physician-reported registry of the COVID-19 GRA were studied. Variables collected at COVID-19 diagnosis included age, sex, race/ethnicity, region, comorbidities, disease activity, time period of COVID-19 diagnosis, glucocorticoid (GC) dose, and immunomodulatory therapy. Immunomodulatory therapy was categorized as: antimalarials only, no SLE therapy, traditional immunosuppressive (IS) drug monotherapy, biologics/targeted synthetic IS drug monotherapy, and biologic and traditional IS drug combination therapy. We used an ordinal COVID-19 severity outcome defined as: not hospitalized/hospitalized without supplementary oxygen; hospitalized with non-invasive ventilation; hospitalized with mechanical ventilation/extracorporeal membrane oxygenation; and death. An ordinal logistic regression model was constructed to assess the association between demographic characteristics, comorbidities, medications, disease activity and COVID-19 severity. This assumed that the relationship between each pair of outcome groups is of the same direction and magnitude.Results:Of 1069 SLE patients included, 1047 (89.6%) were female, with a mean age of 44.5 (SD: 14.1) years. Patient outcomes included 815 (78.8%) not hospitalized/hospitalized without supplementary oxygen; 116 (11.2) hospitalized with non-invasive ventilation, 25 (2.4%) hospitalized with mechanical ventilation/extracorporeal membrane oxygenation and 78 (7.5%) died. In a multivariate model (n=804), increased age [OR=1.03 (1.01, 1.04)], male sex [OR =1.93 (1.21, 3.08)], COVID-19 diagnosis between June 2020 and January 2021 (OR =1.87 (1.17, 3.00)), no IS drug use [OR =2.29 (1.34, 3.91)], chronic renal disease [OR =2.34 (1.48, 3.70)], cardiovascular disease [OR =1.93 (1.34, 3.91)] and moderate/high disease activity [OR =2.24 (1.46, 3.43)] were associated with more severe COVID-19 outcomes. Compared with no use of GC, patients using GC had a higher odds of poor outcome: 0-5 mg/d, OR =1.98 (1.33, 2.96); 5-10 mg/d, OR =2.88 (1.27, 6.56); >10 mg/d, OR =2.01 (1.26, 3.21) (Table 1).Table 1.Characteristics associated with more severe COVID-19 outcomes in SLE. (N=804)OR (95% CI)Age, years1.03 (1.01, 1.04)Sex, Male1.93 (1.21, 3.08)Race/Ethnicity, Non-White vs White1.47 (0.87, 2.50)RegionEuropeRef.North America0.67 (0.29, 1.54)South America0.67 (0.29, 1.54)Other1.93 (0.85, 4.39)Season, June 16th 2020-January 8th 2021 vs January-June 15th 20201.87 (1.17, 3.00)Glucocorticoids0 mg/dayRef.0-5 mg/day1.98 (1.33, 2.96)5-10 mg/day2.88 (1.27, 6.56)=>10 mg/day2.01 (1.26, 3.21)Medication CategoryAntimalarial onlyRef.No IS drugs2.29 (1.34, 3.91)Traditional IS drugs as monotherapy1.17 (0.77, 1.77)b/ts IS drugs as monotherapy1.00 (0.37, 2.71)Combination of traditional and b/ts IS1.00 (0.55, 1.82)Comorbidity BurdenNumber of Comorbidities (excluding renal and cardiovascular disease)1.39 (0.97, 1.99)Chronic renal disease2.34 (1.48, 3.70)Cardiovascular disease1.93 (1.34, 3.91)Disease Activity, Moderate/ high vs Remission/ low 2.24 (1.46, 3.43)IS: immunosuppressive. b/ts: biologics/targeted syntheticsConclusion:Increased age, male sex, glucocorticoid use, chronic renal disease, cardiovascular disease and moderate/high disease activity at time of COVID-19 diagnosis were associated with more severe COVID-19 outcomes in SLE. Potential limitations include possible selection bias (physician reporting), the cross-sectional nature of the data, and the assumptions underlying the outcomes modelling.Acknowledgements:The views expressed here are those of the authors and participating members of the COVID-19 Global Rheumatology Alliance and do not necessarily represent the views of the ACR, EULAR) the UK National Health Service, the National Institute for Health Research (NIHR), or the UK Department of Health, or any other organization.Disclosure of Interests:Manuel F. Ugarte-Gil Grant/research support from: Pfizer, Janssen, Graciela S Alarcon: None declared, Andrea Seet: None declared, Zara Izadi: None declared, Cristina Reategui Sokolova: None declared, Ann E Clarke Consultant of: AstraZeneca, BristolMyersSquibb, GlaxoSmithKline, Exagen Diagnostics, Leanna Wise: None declared, Guillermo Pons-Estel: None declared, Maria Jose Santos: None declared, Sasha Bernatsky: None declared, Lauren Mathias: None declared, Nathan Lim: None declared, Jeffrey Sparks Consultant of: Bristol-Myers Squibb, Gilead, Inova, Janssen, and Optum unrelated to this work., Grant/research support from: Amgen and Bristol-Myers Squibb, Zachary Wallace Consultant of: Viela Bio and MedPace, Grant/research support from: Bristol-Myers Squibb and Principia/Sanofi, Kimme Hyrich Speakers bureau: Abbvie, Grant/research support from: MS, UCB, and Pfizer, Anja Strangfeld Speakers bureau: AbbVie, MSD, Roche, BMS, Pfizer, Grant/research support from: AbbVie, BMS, Celltrion, Fresenius Kabi, Lilly, Mylan, Hexal, MSD, Pfizer, Roche, Samsung, Sanofi-Aventis, and UCB, Laure Gossec Consultant of: Abbvie, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sanofi-Aventis, UCB, Grant/research support from: Lilly, Mylan, Pfizer, Loreto Carmona: None declared, Elsa Mateus Grant/research support from: Pfizer, Abbvie, Novartis, Janssen-Cilag, Lilly Portugal, Sanofi, Grünenthal S.A., MSD, Celgene, Medac, Pharmakern, GAfPA, Saskia Lawson-Tovey: None declared, Laura Trupin: None declared, Stephanie Rush: None declared, Gabriela Schmajuk: None declared, Patti Katz: None declared, Lindsay Jacobsohn: None declared, Samar Al Emadi: None declared, Emily Gilbert: None declared, Ali Duarte-Garcia: None declared, Maria Valenzuela-Almada: None declared, Tiffany Hsu: None declared, Kristin D’Silva: None declared, Naomi Serling-Boyd: None declared, Philippe Dieudé Consultant of: Boerhinger Ingelheim, Bristol-Myers Squibb, Lilly, Sanofi, Pfizer, Chugai, Roche, Janssen unrelated to this work, Grant/research support from: Bristol-Myers Squibb, Chugaii, Pfizer, unrelated to this work, Elena Nikiphorou: None declared, Vanessa Kronzer: None declared, Namrata Singh: None declared, Beth Wallace: None declared, Akpabio Akpabio: None declared, Ranjeny Thomas: None declared, Suleman Bhana Consultant of: AbbVie, Horizon, Novartis, and Pfizer (all <$10,000) unrelated to this work, Wendy Costello: None declared, Rebecca Grainger Speakers bureau: Abbvie, Janssen, Novartis, Pfizer, Cornerstones, Jonathan Hausmann Consultant of: Novartis, Sobi, Biogen, all unrelated to this work (<$10,000), Jean Liew Grant/research support from: Pfizer outside the submitted work, Emily Sirotich Grant/research support from: Board Member of the Canadian Arthritis Patient Alliance, a patient run, volunteer based organization whose activities are largely supported by independent grants from pharmaceutical companies, Paul Sufka: None declared, Philip Robinson Speakers bureau: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB (all < $10,000), Consultant of: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB (all < $10,000), Pedro Machado Speakers bureau: Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000)., Consultant of: Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000), Milena Gianfrancesco: None declared, Jinoos Yazdany Consultant of: Eli Lilly and AstraZeneca unrelated to this project

Background:Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication of COVID-19 and has been reported in approximately one-third of hospitalized patients with COVID-191. Risk factors associated with the development of ARDS include older age and diabetes2. However, little is known about factors associated with ARDS in the setting of COVID-19, in patients with rheumatic disease or those receiving immunosuppressive medications. Prediction algorithms using traditional regression methods perform poorly with rare outcomes, often yielding high specificity but very low sensitivity. Machine learning algorithms optimized for rare events are an alternative approach with potentially improved sensitivity for rare events, such as ARDS in COVID-19 among patients with rheumatic disease.Objectives:We aimed to develop a prediction model for ARDS in people with COVID-19 and pre-existing rheumatic disease using a series of machine learning algorithms and to identify risk factors associated with ARDS in this population.Methods:We used data from the COVID-19 Global Rheumatology Alliance (GRA) Registry from March 24 to Nov 1, 2020. ARDS diagnosis was indicated by the reporting clinician. Five machine learning algorithms optimized for rare events predicted ARDS using 42 variables covering patient demographics, rheumatic disease diagnoses, medications used at the time of COVID-19 diagnosis, and comorbidities. Model performance was assessed using accuracy, area under curve, sensitivity, specificity, positive predictive value, and negative predictive value. Adjusted odds ratios corresponding to the 10 most influential predictors from the best performing model were derived using hierarchical multivariate mixed-effects logistic regression that accounted for within-country correlations.Results:A total of 5,931 COVID-19 cases from 67 countries were included in the analysis. Mean (SD) age was 54.9 (16.0) years, 4,152 (70.0%) were female, and 2,399 (40.5%) were hospitalized. ARDS was reported in 388 (6.5% of total and 15.6% of hospitalized) cases. Statistically significant differences in the risk of ARDS were observed by demographics, diagnoses, medications, and comorbidities using unadjusted univariate comparisons (data not shown). Gradient boosting machine (GBM) had the highest sensitivity (0.81) and was considered the best performing model (Table 1). Hypertension, interstitial lung disease, kidney disease, diabetes, older age, glucocorticoids, and anti-CD20 monoclonal antibodies were associated with the development of ARDS while tumor necrosis factor inhibitors were associated with a protective effect (Figure 1).Table 1.Performance of machine learning algorithms.GBMSVMGLMNETNNETRFAccuracy0.790.680.660.660.67AUC0.750.700.740.580.74Sensitivity0.810.680.650.680.67Specificity0.490.600.730.480.68PPV0.960.960.970.950.97NPV0.160.120.130.090.13GBM: Gradient Boosting Machine, SVM: Support vector machines, GLMNET: Lasso and Elastic-Net Regularized Generalized Linear Models, NNET: Neural Networks, RF: Random Forest. AUC: Area Under Curve; PPV: Positive Predictive Value; NPV: Negative Predictive Value.Conclusion:In this global cohort of patients with rheumatic disease, a machine learning model, GBM, predicted the onset of ARDS with 81% sensitivity using baseline information obtained at the time of COVID-19 diagnosis. These results identify patients who may be at higher risk of severe COVID-19 outcomes. Further studies are necessary to validate the proposed prediction model in external cohorts and to evaluate its clinical utility. Disclaimer: The views expressed here are those of the authors and participating members of the COVID-19 Global Rheumatology Alliance, and do not necessarily represent the views of the ACR, NIH, (UK) NHS, NIHR, or the department of Health.References:[1]Tzotzos SJ, Fischer B, Fischer H, Zeitlinger M. 2020;24(1):516.[2]Wu C, Chen X, Cai Y, et al. JAMA Intern Med. 2020;180(7):934-943.Acknowledgements:The COVID-19 Global Rheumatology Alliance.Disclosure of Interests:Zara Izadi: None declared, Milena Gianfrancesco: None declared, Kimme Hyrich Speakers bureau: Abbvie and grant income from BMS, UCB, and Pfizer, all unrelated to this study., Anja Strangfeld Speakers bureau: AbbVie, MSD, Roche, BMS, Pfizer, outside the submitted work., Grant/research support from: A consortium of 13 companies (among them AbbVie, BMS, Celltrion, Fresenius Kabi, Lilly, Mylan, Hexal, MSD, Pfizer, Roche, Samsung, Sanofi-Aventis, and UCB) supporting the German RABBIT register., Laure Gossec Consultant of: Abbvie, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sanofi-Aventis, UCB., Grant/research support from: Lilly, Mylan, Pfizer, all unrelated to this study., Loreto Carmona Consultant of: Loreto Carmona’s institute works by contract for laboratories among other institutions, such as Abbvie Spain, Eisai, Gebro Pharma, Merck Sharp & Dohme España, S.A., Novartis, Farmaceutica, Pfizer, Roche Farma, Sanofi Aventis, Astellas Pharma, Actelion Pharmaceuticals España, Grünenthal GmbH, and UCB Pharma., Elsa Mateus Grant/research support from: LPCDR received grants from Abbvie, Novartis, Janssen-Cilag, Lilly Portugal, Sanofi, Grünenthal S.A., MSD, Celgene, Medac, Pharmakern, GAfPA and Pfizer., Saskia Lawson-Tovey: None declared, Laura Trupin: None declared, Stephanie Rush: None declared, Gabriela Schmajuk: None declared, Lindsay Jacobsohn: None declared, Patti Katz: None declared, Samar Al Emadi: None declared, Leanna Wise: None declared, Emily Gilbert: None declared, Maria Valenzuela-Almada: None declared, Ali Duarte-Garcia: None declared, Jeffrey Sparks Consultant of: Bristol-Myers Squibb, Gilead, Inova, Janssen, and Optum unrelated to this work., Grant/research support from: Amgen and Bristol-Myers Squibb., Tiffany Hsu: None declared, Kristin D’Silva: None declared, Naomi Serling-Boyd: None declared, Suleman Bhana Employee of: Suleman Bhana reports non-branded marketing campaigns for Novartis (<$10,000)., Wendy Costello: None declared, Rebecca Grainger Speakers bureau: Abbvie, Janssen, Novartis, Pfizer, Cornerstones and travel assistance from Pfizer (all < $10,000)., Jonathan Hausmann Consultant of: Novartis, unrelated to this work (<$10,000)., Jean Liew Grant/research support from: Pfizer, outside the submitted work., Emily Sirotich Grant/research support from: Emily Sirotich is a Board Member of the Canadian Arthritis Patient Alliance, a patient run, volunteer-based organization whose activities are largely supported by independent grants from pharmaceutical companies., Paul Sufka: None declared, Zachary Wallace Consultant of: Viela Bio and MedPace, outside the submitted work., Grant/research support from: Bristol-Myers Squibb and Principia/Sanofi., Pedro Machado Speakers bureau: Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000)., Philip Robinson Consultant of: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB and travel assistance from Roche (all < $10,000)., Jinoos Yazdany Consultant of: Eli Lilly and Astra Zeneca, unrelated to this project.

Kitagawa, Yuko, Stephan F. Van Eeden, Darlene M. Redenbach, Maleki Daya, Blair A. M. Walker, Maria E. Klut, Barry R. Wiggs, and James C. Hogg. Effect of mechanical deformation on structure and function of polymorphonuclear leukocytes. J. Appl. Physiol. 82(5): 1397–1405, 1997.—The present studies were designed to test the hypothesis that mechanical deformation of polymorphonuclear leukocytes (PMN) leads to functional changes that might influence their transit in the pulmonary capillaries. Human leukocytes were passed through 5- or 3-μm-pore polycarbonate filters under controlled conditions. Morphometric analysis showed that the majority of PMN were deformed and that this deformation persisted longer after filtration through 3-μm filters than through 5-μm filters ( P < 0.05) but did not result in the cytoskeletal polarization characteristic of migrating cells. Flow cytometric studies of the filtered PMN showed that there was a transient increase in the cytosolic free Ca2+ concentration after both 3- and 5-μm filtration ( P< 0.01) with an increase in F-actin content after 3-μm filtration ( P < 0.05). AlthoughL-selectin expression on PMN was not changed by either 5- or 3-μm filtration, CD18 and CD11b were increased by 3-μm filtration ( P < 0.05). Priming of the PMN with N-formyl-methionyl-leucyl-phenylalanine (0.5 nM) before filtration resulted in an increase of CD11b by both 5 ( P < 0.05)- and 3-μm ( P < 0.01) filtration. Neither 5- nor 3-μm filtration induced hydrogen peroxide production. We conclude that mechanical deformation of PMN, similar to what occurs in the pulmonary microvessels, induces both structural and functional changes in the cells, which might influence their passage through the pulmonary capillary bed.

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Abstract Background Understanding the evolving epidemiology of Streptococcus pneumoniae serotypes is important for assessing the current and potential future immunization programs. In Canada, Invasive pneumococcal disease (IPD) is mandatory reportable to provincial/territorial public health. Provinces and territories voluntarily submit annual IPD data to the Canadian Notifiable Disease Surveillance System (CNDSS), which publishes information on IPD cases and incidence rates, however serotype data are not available. Provinces/territories also voluntarily submit IPD isolates to the National Microbiology laboratory (NML) for serotyping; provinces that conduct their own serotyping submit this information. The NML produces comprehensive IPD surveillance reports including serotype distribution; due to lack of population denominator, no incidence rates are available. The two surveillance programs are not linked. The objective of the study is to assess the representativeness of the NML surveillance as compared to the CNDSS and provincial reportable diseases databases. Methods Over the study time period (2010-2017), we compared annual IPD case counts between the NML and CNDSS reports. Due to the difference in age grouping between CNDSS and NML, comparison was limited to these groups: all age, &lt; 5, 5-14 and &gt; 15 years. In addition, the IPD counts from NML were compared to data from four largest provinces. Results For &lt; 5 group, NML reported 91% of CNDSS case count whereas for 5-14 and &gt; 15 years of age, it was 81% and 79%, respectively. Compared to the corresponding provincial databases, NML reported 91%, 97%, and 93% case counts for Ontario, British Columbia, and Alberta, respectively, while it was only 47% for Quebec. Further analysis revealed that the discrepancy in Quebec is the result of under-representation of &gt;5 populations. Figure 1: Comparison of age stratified IPD case counts between CNDSS and NML Figure 2. Comparison of all age IPD case counts between NML and provincial databases Conclusion IPD surveillance conducted by NML has been instrumental to gain insight into the evolving epidemiology of S. pneumoniae serotypes in Canada. Comparisons of IPD counts from NML surveillance reports with reportable disease databases revealed different levels of concordance across provinces and age groups. The limitations of NML surveillance including incomplete or inconsistent reporting should be taken into consideration when interpreting the data. Disclosures Rajeev M. Nepal, PhD, Pfizer (Employee) Stephane B. Dion, PhD, Pfizer (Employee) Ana Gabriela Grajales, MD, Pfizer (Employee) Maria Major, B.Sc., MPH, Pfizer (Employee) Alejandro Cane, MD, Pfizer (Employee) Jelena Vojicic, MD, Pfizer (Employee)

BackgroundIn Germany 37.1% of dispensed medicinal products were intended to use in self-medication in 2017.1 An investigation showed that 25.2% of children and adolescents used self-medication in Germany.2 Hence, pharmacists’ education needs to include training for competence in consultation.3A modern method to train this competence is the use of OSCEs (Objective Structured Clinical Examinations). The aim of this study was to assess whether the use of OSCEs in pharmacy students to train the consultation performance on self-medication is more effective than a conservative teaching method.MethodsThis randomised controlled investigation was conducted in a pre-post-design with pre-OSCEs before training and post-OSCEs after training in each group. Clinical skills at baseline and after the training were measured. Forty students in their last year of pharmacy studies were randomised into a control and an intervention group. The control group attended a lecture on self-medication and the intervention group had additionally to the lecture one hour of OSCEs for training purpose. An analytical checklist was used for measuring consultation skills and a global rating scale for assessing communication skills.ResultsComplete data was received from 30 students (n=16 intervention group, n=14 control group). Consultation skills improved significantly (analytical checklist: 19.88% ± 10.95% intervention group vs. 9.29% ± 10.89% control group, p< 0.05). However, the communication skills (global rating scale: 20.83% ± 24.33% in the intervention group vs. 11.90% ± 17.12% in the control group, p= 0.380) did not improve significantly during the one-hour training period.ConclusionOSCEs for training purpose are an effective method to convey pharmacy students consultation skills in self-medication. However, communication skills need more training. Based on these results OSCEs on self-medication for the paediatric population should be investigated. This is relevant due to the frequency of self-medication in the paediatric population.ReferencesAbda.de. [Internet]. Berlin: Federal union of German associations of pharmacists. Numbers, data, facts 2016. [Cited January 30, 2019]. Available from: https://www.abda.de/fileadmin/assets/ZDF/ZDF_2018/ABDA_ZDF_2018_Brosch.pdf Du Y, Knopf H. Self-medication among children and adolescents in Germany: results of the National Health Survey for children and adolescents (KiGGS). Br J Clin Pharmacol 2009;68:599–608.Joint Statement by the International Pharmaceutical Federation (FIP) and the World Self Medication Industry (WSMI). [Internet]. Responsible Self-medication. 1998. [Cited January 30, 2019]. Available from: https://www.fip.org/www/uploads/database_file.php?id=241&table_id=.Disclosure(s)Imaneh Farahani, Anna Laven, Samieh Farahani, Maira A. Deters, Martin Feickert, Fabian K. Suessenbach, Holger Schwender and Stephanie Laeer declare that they have no conflict of interest.

Este artigo apresenta esquema didático e crítico, a partir do Método de Marx, das teorias Positivistas, Funcionalistas, Estruturalistas e Pós-Modernistas. Conclui que a dialética, a contradição e a totalidade permitem compreender que a educação e o ensino são determinados pelas condições de produção e distribuição, sem que essa suposição signifique uma posição mecânica, imobilistica ou idealista. As possibilidades de pesquisa, neste método, são a investigação sobre a distribuição e circulação do conhecimento e, também, a luta por uma escola universal que leve à crítica da realidade concreta.REFERÊNCIASANDERSON, Perry. Neoliberalismo: un balance provisório. In. SADER, Emir. GENTILI, Pablo. La Trama del Neoliberalismo. Mercado, crisis y exclusión social. Buenos Aires: Clacso, 2003. p. 11-18BOURDIEU, Pierre. A escola conservadora: as desigualdades frente à escola e à cultura. In:NOGUEIRA, Maria Alice; CATANI, Afrânio (orgs). Escritos de educação. Petrópolis, RJ: Vozes, 1998, p. 39-64BRECHT, Bertolt. (1955). A Vida de Galileu. São Paulo: Abril Cultural, 1977BURTT, Edwin A. As bases metafísicas da ciência moderna. Tradução: José Viegas Filho. Orlando Araújo Henriques. Editora Universidade de Brasília, 1983CHASIN, J. Marx: estatuto ontológico e resolução metodológica. São Paulo: Boitempo, 2009COUTINHO, Carlos Nelson. O Estruturalismo e a Miséria da Razão. São Paulo: Expressão Popular, 2010DESCARTES, René. (1637). Discurso do Método. Tradução : Maria Ermantina Galvão. São Paulo: Martins Fontes, 2001.DILTHEY, Wilhelm. (1883). A construção do mundo histórico nas ciências humanas. Tradução : Marcos Casanova. São Paulo : Editora UNESP, 2010.DOSSE, François. História do Estruturalismo. O campo do signo, 1945/1966. Campinas, SP: Editora da Universidade Estadual de Campinas, 1993DURKHEIM, Émile. (1922). Educação e Sociologia. Tradução: Stephania Matousek. Petrópolis: Vozes, 2011 EAGLETON, Terry. Ideologia. São Paulo: Editora da Universidade Estadual Paulista: Editora Boitempo, 1997FREDERICO, Celso. O jovem Marx. 1843-1844: as origens da ontologia do ser social. São Paulo: Expressão Popular, 2009GIL, Rosa María Cifuentes. Diseño de proyectos de investigación cualitativa. Buenos Aires: NOVEDUC, 2014HEGEL, G.W.F. (1820) Linhas Fundamentais da Filosofia do Direito ou Direito Natural e Ciência do Estado em Compêndio. Tradução: Marcos L. Müller. Analytica, Vol 1, N.01, 1994HOUAISS. Antônio. Novo Dicionário Houaiss da Língua Portuguesa. Rio de Janeiro: Editora Objetiva, 2001JAPIASSU, Hilton. Introdução ao pensamento epistemológico. Rio de Janeiro: F. Alves, 1934KANT, Immanuel. (1781) Crítica da razão pura. Tradução: Manuela Pinto dos Santos. Alexandre Fradique Morujão. Lisboa: Fundação Calouste Gulbenkian, 2001KONDER, Leandro. O que é dialética. Brasiliense, 1990KOSIK, Karel (1961). Tradução: Célia Neves. Alderico Toríbio. Dialética do Concreto. São Paulo: Paz e Terra, 2002LUKÁCS, György. (1972) Ontologia do Ser Social I. Os Princípios Ontológicos Fundamentais de Marx. Tradução: Carlos Nelson Coutinho. São Paulo: Livraria Editora Ciências Humanas LTDA, S/DMARX, Karl. (1859). Para a crítica da economia política. Do capital. O rendimento e suas fontes. Tradução: Edgard Malagodi. São Paulo: Editora Nova Cultural, 1999MARX, Karl. ENGELS, Friedrich (1846). A ideologia alemã. Tradução: Rubens Enderle. Nélio Schneider. Luciano Cavini Martorano. São Paulo: Boitempo, 2014 MARX, Karl. ENGELS, Friedrich (1848). Manifesto do Partido Comunista. Tradução: José Barata-Moura e Francisco Melo. Lisboa: Editorial Avante, 1997MARX, Karl. (1847) A miséria da Filosofia. Tradução: José Paulo Netto. São Paulo: Global, 1985MARX, Karl. ENGELS, Friedrich. Critique de l’éducationet de l’einsegnement. Introduction, traductionet notes de Roger Dangeville. In. DANGEVILLE. Roger. Une anthólogie de Marx-Engels surl’éducation, l’einsegnement et la formatión professionnelle. Librairie François Maspero: Paris, 1976MORROW, Raymond Allen. TORRES, Carlos Alberto. Teoria social e educação. Uma crítica das teorias da Reprodução Social e Cultural. Porto, Portugal: Editora Afrontamento, 1997.SAUSSURE, Ferdinand. (1910). Curso de Linguística Geral. Tradução: Antônio Chelini. José Paulo Paes. Izidoro Blikstein. São Paulo: Cultrix, 2010.SAUTU, Ruth. BONIOLO, Paula. DALLE, Pablo. ELBERT, Rodolfo. Manual de metodología. Contrucción del marco teórico, formulación de los objetivos y elección de la metodología. Buenos Aires: Prometeo Libros, 2010VYGOTSKI, Lev. S. (1931) Obras Escogidas. Tomo III. Tradução: José María Bravo: Madri: Visor, 2000Recebido em 05-05-2018/ Aceito em 10-08-2018.

Background:Targeted DMARDs may dampen the inflammatory response in COVID-19, perhaps leading to a less severe clinical course. However, some DMARD targets may impair viral immune defenses. Due to sample size limitations, previous studies of DMARD use and COVID-19 outcomes have combined several heterogeneous rheumatic diseases and medications, investigating a single outcome (e.g., hospitalization).Objectives:To investigate the associations of baseline use of biologic or targeted synthetic (b/ts) DMARDs with a range of poor COVID-19 outcomes in rheumatoid arthritis (RA).Methods:We analyzed voluntarily reported cases of COVID-19 in patients with rheumatic diseases in the COVID-19 Global Rheumatology Alliance physician registry (March 12, 2020 - January 6, 2021). We investigated RA treated with b/tsDMARD at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAK), interleukin-6 inhibitors (IL6i), or tumor necrosis factor inhibitors (TNFi). The outcome was an ordinal scale (1-4) for COVID-19 severity: 1) no hospitalization, 2) hospitalization without oxygen need, 3) hospitalization with any oxygen need or ventilation, or 4) death. Baseline covariates including age, sex, smoking, obesity, comorbidities (e.g., cardiovascular disease, cancer, interstitial lung disease [ILD]), concomitant non-biologic DMARD use, glucocorticoid use/dose, RA disease activity, country, and calendar time were used to estimate propensity scores (PS) for b/tsDMARD. The primary analysis used PS matching to compare each drug class to TNFi. Ordinal logistic regression estimated ORs for the COVID-19 severity outcome. In a sensitivity analysis, we used traditional multivariable ordinal logistic regression adjusting for covariates without matching.Results:Of the 1,673 patients with RA on b/tsDMARDs at the onset of COVID-19, (mean age 56.7 years, 79.6% female) there were n=154 on ABA, n=224 on RTX, n=306 on JAK, n=180 on IL6i, and n=809 on TNFi. Overall, 498 (34.3%) were hospitalized and 112 (6.7%) died. Among all patients, 353 (25.3%) were ever smokers, 197 (11.8%) were obese, 462 (27.6%) were on glucocorticoids, 1,002 (59.8%) were on concomitant DMARDs, and 299 (21.7%) had moderate/high RA disease activity. RTX users were more likely than TNFi users to have ILD (11.6% vs. 1.7%) and history of cancer (7.1% vs. 2.0%); JAK users were more likely than TNFi users to be obese (17.3% vs. 9.0%). After propensity score matching, RTX was strongly associated with greater odds of having a worse outcome compared to TNFi (OR 3.80, 95% CI 2.47, 5.85; Figure). Among RTX users, 42 (18.8%) died compared to 27 (3.3%) of TNFi users (Table). JAK use was also associated with greater odds of having a worse COVID-19 severity (OR 1.52, 95%CI 1.02, 2.28). ABA or IL6i use were not associated with COVID-19 severity compared to TNFi. Results were similar in the sensitivity analysis and after excluding cancer or ILD.Table 1.Frequencies for the ordinal COVID-19 severity outcome for patients with RA on biologic or targeted synthetic DMARDs (n=1673).COVID-19 outcomes by severity scale (n,%)ABAn=154RTXn=224JAKn=306IL6in=180TNFi n=8091)Not hospitalized113 (73.3%)121 (54.0%)220 (71.9%)150 (83.3%)666 (82.3%)2)Hospitalization without oxygenation10 (6.5%)14 (6.2%)11 (3.6%)9 (5.0%)53 (6.5%)3)Hospitalization with any oxygenation or ventilation16 (10.4%)47 (21.0%)52 (17.0%)16 (8.9%)63 (7.8%)4)Death15 (9.7%)42 (18.8%)23 (7.5%)5 (2.8%)27 (3.3%)Conclusion:In this large global registry of patients with RA and COVID-19, baseline use of RTX or JAK was associated with worse severity of COVID-19 compared to TNFi use. The very elevated odds for poor COVID-19 outcomes in RTX users highlights the urgent need for risk-mitigation strategies, such as the optimal timing of vaccination. The novel association of JAK with poor COVID-19 outcomes requires replication.Acknowledgements:The views expressed here are those of the authors and participating members of the COVID-19 Global Rheumatology Alliance and do not necessarily represent the views of the ACR, EULAR, the UK National Health Service, the National Institute for Health Research, the UK Department of Health, or any other organization.Disclosure of Interests:Jeffrey Sparks Consultant of: Bristol-Myers Squibb, Gilead, Inova, Janssen, and Optum, unrelated to this work, Grant/research support from: Amgen and Bristol-Myers Squibb, unrelated to this work, Zachary Wallace Consultant of: Viela Bio and MedPace, outside the submitted work., Grant/research support from: Bristol-Myers Squibb and Principia/Sanofi, Andrea Seet: None declared, Milena Gianfrancesco: None declared, Zara Izadi: None declared, Kimme Hyrich Speakers bureau: Abbvie unrelated to this study, Grant/research support from: BMS, UCB, and Pfizer, all unrelated to this study, Anja Strangfeld Paid instructor for: AbbVie, MSD, Roche, BMS, Pfizer, outside the submitted work, Grant/research support from: grants from a consortium of 13 companies (among them AbbVie, BMS, Celltrion, Fresenius Kabi, Lilly, Mylan, Hexal, MSD, Pfizer, Roche, Samsung, Sanofi-Aventis, and UCB) supporting the German RABBIT register, outside the submitted work, Laure Gossec Consultant of: Abbvie, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sanofi-Aventis, UCB, unrelated to this study, Grant/research support from: Lilly, Mylan, Pfizer, all unrelated to this study, Loreto Carmona: None declared, Elsa Mateus Grant/research support from: grants from Abbvie, Novartis, Janssen-Cilag, Lilly Portugal, Sanofi, Grünenthal S.A., MSD, Celgene, Medac, Pharmakern, GAfPA; grants and non-financial support from Pfizer, outside the submitted work, Saskia Lawson-Tovey: None declared, Laura Trupin: None declared, Stephanie Rush: None declared, Gabriela Schmajuk: None declared, Patti Katz: None declared, Lindsay Jacobsohn: None declared, Samar Al Emadi: None declared, Leanna Wise: None declared, Emily Gilbert: None declared, Ali Duarte-Garcia: None declared, Maria Valenzuela-Almada: None declared, Tiffany Hsu: None declared, Kristin D’Silva: None declared, Naomi Serling-Boyd: None declared, Philippe Dieudé Consultant of: Boerhinger Ingelheim, Bristol-Myers Squibb, Lilly, Sanofi, Pfizer, Chugai, Roche, Janssen unrelated to this work, Grant/research support from: Bristol-Myers Squibb, Chugaii, Pfizer, unrelated to this work, Elena Nikiphorou: None declared, Vanessa Kronzer: None declared, Namrata Singh: None declared, Manuel F. Ugarte-Gil Grant/research support from: Janssen and Pfizer, Beth Wallace: None declared, Akpabio Akpabio: None declared, Ranjeny Thomas: None declared, Suleman Bhana Consultant of: AbbVie, Horizon, Novartis, and Pfizer (all <$10,000) unrelated to this work, Wendy Costello: None declared, Rebecca Grainger Speakers bureau: Abbvie, Janssen, Novartis, Pfizer, Cornerstones, Jonathan Hausmann Consultant of: Novartis, Sobi, Biogen, all unrelated to this work (<$10,000), Jean Liew Grant/research support from: Yes, I have received research funding from Pfizer outside the submitted work., Emily Sirotich Grant/research support from: Board Member of the Canadian Arthritis Patient Alliance, a patient run, volunteer based organization whose activities are largely supported by independent grants from pharmaceutical companies, Paul Sufka: None declared, Philip Robinson Speakers bureau: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB (all < $10,000), Consultant of: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB (all < $10,000), Pedro Machado Speakers bureau: Yes, I have received consulting/speaker’s fees from Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000)., Consultant of: Yes, I have received consulting/speaker’s fees from Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000)., Jinoos Yazdany Consultant of: Eli Lilly and AstraZeneca unrelated to this project

Target setting. In the modern musical culture of the Republic of Moldova M. V. Sechkin stands out as one of the key figures. He proved to be a multi skilled musician: piano player, conductor, and pedagogue. The scientific challenge disclosed in the article touches on creation of a coherent reflection of the work conducted by M. Sechkin in musical and artistic institutions of the Republic of Moldova during 1988–2015. Thus, notably contributing to the theoretical perception of the process of musical art development in the Republic of Moldova at the turn of the 21st century while filling up the gap in studying the history of Moldovan musical culture. Review of literature. The activity conducted by M. Sechkin was not reflected in the scientific literature. The present paper is the first attempt to present the creative portrait of the musician by summarizing press articles and a range of interviews. The purpose of this paper is confined to disclosing the contribution made by the famous piano player, conductor, and pedagogue M. Sechkin in the process of musical art development in Moldova at the turn of the 21st century. Research methodology. In the research of creative activity of M. Sechkin, use has been made of a complex of methods applicable in modern study of art: the empirical level of scientific research was established through informal personal conversations with M. Sechkin and other musicians, directly linked with his activity. Applied at the theoretical level were general scientific methods, such as analysis and synthesis, induction and deduction, comparison, etc. Statement of basic material. Over the years, M. V. Sechkin, born on March 31, 1943 in the Ukrainian City of Kharkov, has contributed decisively to the development of musical culture in the Republic of Moldova as a pianist, opera and symphony orchestra conductor, professor and public figure. He took his first lessons in music from his mother Maria Sechkin Zakharchenko, the follower of K. N. Igumnov. He attended the profile secondary musical school, class of Regina Gorovitz – the sister to the famous pianist Vladimir Gorovitz. In 1966, M. Sechkin graduated from Kharkov Conservatoire as a pianist on the class of Professor Mikhail Khazanovsky and then selected to remain with the Chair as an assistant. However, his dream of making a carrier of symphony and opera conductor has taken the young musician to a different path. The interest for conducting appeared under the influence of the art of conducting revealed by Leonid Khudoley, disciple of Nikolay Golovanov. Therefore, two years later, after graduation, M. Sechkin has entered the faculty of conductors at Kharkov Institute of Arts. One year later, he moves to Kyiv Conservatoire named after P. I. Tchaikovsky, where he attended the class of Professor Mikhail Kanershtein, disciple of one of the founders of the Soviet school of conducting Nicolay Malko. Next followed probation assistantship, where M. Sechkin attended a training course headed by the outstanding Ukrainian conductor Stephan Turchak. Having accomplished his probation assistantship, M. Sechkin has joined the Symphonic orchestra of Zaporozhye Philharmonics and later on invited to Donetsk Opera Theatre, where he mastered a rather comprehensive theatrical repertoire. The Chisinau (Moldova) period of maestro’s creative biography started beck in 1988, when he accepted the invitation to join the Moldovan State Conservatoire as Professor of the Chair of Special Piano and the Chair of Operatic Training. By then he headed the Students Symphony Orchestra, being one of the first conductors of Opera Studio. The Studio repertoire included the best images of West European and Russian opera classics. Prepared from the scratch were such operas as Carmen by G. Bizet and the Noblewoman Vera Sheloga by N. А. Rimsky Korsakov. The students – alumni of this conservatoire then worked successfully at the National Opera Theatre, performed in prestigious opera scenes around the world; among these one could mention Petru Racovita, Natalia Margarit, Lilya Sholomey, Yuri Gasca, Robert Khvalov, Stephan Curudimov, Mefodie Bujor, and Liliana Lavric. The Opera Studio Orchestra was touring in Italy and Spain. For a number of decades, M. Sechkin acted as one of the key conductors at the National Opera and Ballet Theatre, while from 1990 to 1992 acted as the Principal Conductor and the Art Director. Here he worked on staging the ballets Romeo & Juliette by S. Prokofiev, Spartacus by А. Khachaturian, and operas the Marriage of Figaro by W. Mozart, Don Carlos by G. Verdi, and Iolanta by P. I. Tchaikovsky. In parallel to the theatre plays, M. Sechkin has brightly proven his qualities as a conductor of the Symphony Orchestra of the National Philharmonics named after S. Lunchevici. Under his leadership (2008–2013), the orchestra performed more than twenty show programs, including premiere hits by P. Tchaikovsky (Symphony No. 5, symphony Manfred), A. Scriabin (Symphony No. 2 and No. 3), and S. Rachmaninoff (Symphony No. 3). Many of the musicians are marking high conducting mastery of M. Sechkin in performing orchestral accompaniment and special work with the soloists prior to orchestra performance. Likewise appreciated was the work of maestro with young musicians. The conductor devotes a lot of his time to promoting the oeuvre of Moldovan composers. Since 2000 and until nowadays, within the frameworks of the Days of New Music Festival, jointly with the National Philharmonics Orchestra, the maestro prepared a number of programs compiled from the works of V. Polyakov, V. Zagorsky, V. Rotaru, A. Luxemburg, O. Negruza, B. Dubossarsky, and Z. Tcaci. In 30 years of his activity in Chisinau, M. Sechkin cooperated with all of the known orchestra ensembles. Back in 90th, maestro was successfully touring with the National Opera and Ballet Theatre in Italy, Spain, Portugal, Switzerland, Rumania and Chile. In Rumania, M. Sechkin was working full time as a conductor and then as the principal conductor of the Symphony Orchestra of the city of Botosani (1998–2013), where he managed to stage about 70 show programs. The multifaceted and fruitful activity of the musician was repeatedly marked with Certificates of Honor and Diplomas. In 1996, he was decorated with the award Maestru &#238;n Art&#259; (Master of Arts) and in 2018 with the noble award of the People’s Artist of the Republic of Moldova. Conclusions and prospects. While appreciating the contribution made by this outstanding musician into the development of the musical culture in the Republic of Moldova, one could clearly see the determinant trajectory of his life and artistic journey – the stalwart devotion to music, musical education, nurturing young performers and listeners of different age group generations.

Abstract. Across the world, nature-triggered disasters fuelled by climate change are worsening. Some two billion people have been affected by the consequences of natural hazards over the last ten years, 95% of which were weather-related (such as floods and windstorms). Fires swept across large parts of California, and in Australia caused unprecedented destruction to lives, wildlife and bush. This picture is likely to become the new normal, and indeed may worsen if unchecked. The Intergovernmental Panel on Climate Change (IPCC) estimates that in some locations, disaster that once had a once-in-a-century frequency may become annual events by 2050.Disaster management needs to keep up. Good cooperation and coordination of crisis response operations are of critical importance to react rapidly and adequately to any crisis situation, while post-disaster recovery presents opportunities to build resilience towards reducing the scale of the next disaster. Technology to support crisis response has advanced greatly in the last few years. Systems for early warning, command and control and decision-making have been successfully implemented in many countries and regions all over the world. Efforts to improve humanitarian response, in particular in relation to combating disasters in rapidly urbanising cities, have also led to better approaches that grapple with complexity and uncertainty.The challenges however are daunting. Many aspects related to the efficient collection and integration of geo-information, applied semantics and situational awareness for disaster management are still open, while agencies, organisations and governmental authorities need to improve their practices for building better resilience.Gi4DM 2020 marked the 13th edition of the Geoinformation for Disaster Management series of conferences. The first conference was held in 2005 in the aftermath of the 2004 Indian Ocean earthquake and tsunami which claimed the lives of over 220,000 civilians. The 2019-20 Australian Bushfire Season saw some 18.6 million Ha of bushland burn, 5,900 buildings destroyed and nearly three billion vertebrates killed. Gi4DM 2020 then was held during Covid-19 pandemic, which took the lives of more than 1,150,000 people by the time of the conference. The pandemic affected the organisation of the conference, but the situation also provided the opportunity to address important global problems.The fundamental goal of the Gi4DM has always been to provide a forum where emergency responders, disaster managers, urban planners, stakeholders, researchers, data providers and system developers can discuss challenges, share experience, discuss new ideas and demonstrate technology. The 12 previous editions of Gi4DM conferences were held in Delft, the Netherlands (March 2005), Goa, India (September 2006), Toronto, Canada (May 2007), Harbin, China (August 2008), Prague, Czech Republic (January 2009), Torino, Italy (February 2010), Antalya, Turkey (May 2011), Enschede, the Netherlands (December, 2012), Hanoi, Vietnam (December 2013), Montpellier, France (2015), Istanbul, Turkey (2018) and Prague, Czech Republic (2019). Through the years Gi4DM has been organised in cooperation with different international bodies such as ISPRS, UNOOSA, ICA, ISCRAM, FIG, IAG, OGC and WFP and supported by national organisations.Gi4DM 2020 was held as part of Climate Change and Disaster Management: Technology and Resilience for a Troubled World. The event took place through the whole week of 30th of November to 4th of December, Sydney, Australia and included three events: Gi4DM 2020, NSW Surveying and Spatial Sciences Institute (NSW SSSI) annual meeting and Urban Resilience Asia Pacific 2 (URAP2).The event explored two interlinked aspects of disaster management in relation to climate change. The first was geo-information technologies and their application for work in crisis situations, as well as sensor and communication networks and their roles for improving situational awareness. The second aspect was resilience, and its role and purpose across the entire cycle of disaster management, from pre-disaster preparedness to post-disaster recovery including challenges and opportunities in relation to rapid urbanisation and the role of security in improved disaster management practices.This volume consists of 22 scientific papers. These were selected on the basis of double-blind review from among the 40 short papers submitted to the Gi4DM 2020 conference. Each paper was reviewed by two scientific reviewers. The authors of the papers were encouraged to revise, extend and adapt their papers to reflect the comments of the reviewers and fit the goals of this volume. The selected papers concentrate on monitoring and analysis of various aspects related to Covid-19 (4), emergency response (4), earthquakes (3), flood (2), forest fire, landslides, glaciers, drought, land cover change, crop management, surface temperature, address standardisation and education for disaster management. The presented methods range from remote sensing, LiDAR and photogrammetry on different platforms to GIS and Web-based technologies. Figure 1 illustrates the covered topics via wordcount of keywords and titles.The Gi4DM 2020 program consisted of scientific presentations, keynote speeches, panel discussions and tutorials. The four keynotes speakers Prof Suzan Cutter (Hazard and Vulnerability Research Institute, USC, US), Jeremy Fewtrell (NSW Fire and Rescue, Australia), Prof Orhan Altan (Ad-hoc Committee on RISK and Disaster Management, GeoUnions, Turkey) and Prof Philip Gibbins (Fenner School of Environment and Society, ANU, Australia) concentrated on different aspects of disaster and risk management in the context of climate change. Eight tutorials offered exciting workshops and hands-on on: Semantic web tools and technologies within Disaster Management, Structure-from-motion photogrammetry, Radar Remote Sensing, Dam safety: Monitoring subsidence with SAR Interferometry, Location-based Augmented Reality apps with Unity and Mapbox, Visualising bush fires datasets using open source, Making data smarter to manage disasters and emergency situational awareness and Response using HERE Location Services. The scientific sessions were blended with panel discussions to provide more opportunities to exchange ideas and experiences, connect people and researchers from all over the world.The editors of this volume acknowledge all members of the scientific committee for their time, careful review and valuable comments: Abdoulaye Diakité (Australia), Alexander Rudloff (Germany), Alias Abdul Rahman (Malaysia), Alper Yilmaz (USA), Amy Parker (Australia), Ashraf Dewan (Australia), Bapon Shm Fakhruddin (New Zealand), Batuhan Osmanoglu (USA), Ben Gorte (Australia), Bo Huang (Hong Kong), Brendon McAtee (Australia), Brian Lee (Australia), Bruce Forster (Australia), Charity Mundava (Australia), Charles Toth (USA), Chris Bellman (Australia), Chris Pettit (Australia), Clive Fraser (Australia), Craig Glennie (USA), David Belton (Australia), Dev Raj Paudyal (Australia), Dimitri Bulatov (Germany), Dipak Paudyal (Australia), Dorota Iwaszczuk (Germany), Edward Verbree (The Netherlands), Eliseo Clementini (Italy), Fabio Giulio Tonolo (Italy), Fazlay Faruque (USA), Filip Biljecki (Singapore), Petra Helmholz (Australia), Francesco Nex (The Netherlands), Franz Rottensteiner (Germany), George Sithole (South Africa), Graciela Metternicht (Australia), Haigang Sui (China), Hans-Gerd Maas (Germany), Hao Wu (China), Huayi Wu (China), Ivana Ivanova (Australia), Iyyanki Murali Krishna (India), Jack Barton (Australia), Jagannath Aryal (Australia), Jie Jiang (China), Joep Compvoets (Belgium), Jonathan Li (Canada), Kourosh Khoshelham (Australia), Krzysztof Bakuła (Poland), Lars Bodum (Denmark), Lena Halounova (Czech Republic), Madhu Chandra (Germany), Maria Antonia Brovelli (Italy), Martin Breunig (Germany), Martin Tomko (Australia), Mila Koeva (The Netherlands), Mingshu Wang (The Netherlands), Mitko Aleksandrov (Australia), Mulhim Al Doori (UAE), Nancy Glenn (Australia), Negin Nazarian (Australia), Norbert Pfeifer (Austria), Norman Kerle (The Netherlands), Orhan Altan (Turkey), Ori Gudes (Australia), Pawel Boguslawski (Poland), Peter van Oosterom (The Netherlands), Petr Kubíček (Czech Republic), Petros Patias (Greece), Piero Boccardo (Italy), Qiaoli Wu (China), Qing Zhu (China), Riza Yosia Sunindijo (Australia), Roland Billen (Belgium), Rudi Stouffs (Singapore), Scott Hawken (Australia), Serene Coetzee (South Africa), Shawn Laffan (Australia), Shisong Cao (China), Sisi Zlatanova (Australia), Songnian Li (Canada), Stephan Winter (Australia), Tarun Ghawana (Australia), Ümit Işıkdağ (Turkey), Wei Li (Australia), Wolfgang Reinhardt (Germany), Xianlian Liang (Finland) and Yanan Liu (China).The editors would like to express their gratitude to all contributors, who made this volume possible. Many thanks go to all supporting organisations: ISPRS, SSSI, URAP2, Blackash, Mercury and ISPRS Journal of Geoinformation. The editors are grateful to the continued support of the involved Universities: The University of New South Wales, Curtin University, Australian National University and The University of Melbourne.

Abstract. Across the world, nature-triggered disasters fuelled by climate change are worsening. Some two billion people have been affected by the consequences of natural hazards over the last ten years, 95% of which were weather-related (such as floods and windstorms). Fires swept across large parts of California, and in Australia caused unprecedented destruction to lives, wildlife and bush. This picture is likely to become the new normal, and indeed may worsen if unchecked. The Intergovernmental Panel on Climate Change (IPCC) estimates that in some locations, disaster that once had a once-in-a-century frequency may become annual events by 2050.Disaster management needs to keep up. Good cooperation and coordination of crisis response operations are of critical importance to react rapidly and adequately to any crisis situation, while post-disaster recovery presents opportunities to build resilience towards reducing the scale of the next disaster. Technology to support crisis response has advanced greatly in the last few years. Systems for early warning, command and control and decision-making have been successfully implemented in many countries and regions all over the world. Efforts to improve humanitarian response, in particular in relation to combating disasters in rapidly urbanising cities, have also led to better approaches that grapple with complexity and uncertainty.The challenges however are daunting. Many aspects related to the efficient collection and integration of geo-information, applied semantics and situational awareness for disaster management are still open, while agencies, organisations and governmental authorities need to improve their practices for building better resilience.Gi4DM 2020 marked the 13th edition of the Geoinformation for Disaster Management series of conferences. The first conference was held in 2005 in the aftermath of the 2004 Indian Ocean earthquake and tsunami which claimed the lives of over 220,000 civilians. The 2019-20 Australian Bushfire Season saw some 18.6 million Ha of bushland burn, 5,900 buildings destroyed and nearly three billion vertebrates killed. Gi4DM 2020 then was held during Covid-19 pandemic, which took the lives of more than 1,150,000 people by the time of the conference. The pandemic affected the organisation of the conference, but the situation also provided the opportunity to address important global problems.The fundamental goal of the Gi4DM has always been to provide a forum where emergency responders, disaster managers, urban planners, stakeholders, researchers, data providers and system developers can discuss challenges, share experience, discuss new ideas and demonstrate technology. The 12 previous editions of Gi4DM conferences were held in Delft, the Netherlands (March 2005), Goa, India (September 2006), Toronto, Canada (May 2007), Harbin, China (August 2008), Prague, Czech Republic (January 2009), Torino, Italy (February 2010), Antalya, Turkey (May 2011), Enschede, the Netherlands (December, 2012), Hanoi, Vietnam (December 2013), Montpellier, France (2015), Istanbul, Turkey (2018) and Prague, Czech Republic (2019). Through the years Gi4DM has been organised in cooperation with different international bodies such as ISPRS, UNOOSA, ICA, ISCRAM, FIG, IAG, OGC and WFP and supported by national organisations.Gi4DM 2020 was held as part of Climate Change and Disaster Management: Technology and Resilience for a Troubled World. The event took place through the whole week of 30th of November to 4th of December, Sydney, Australia and included three events: Gi4DM 2020, NSW Surveying and Spatial Sciences Institute (NSW SSSI) annual meeting and Urban Resilience Asia Pacific 2 (URAP2).The event explored two interlinked aspects of disaster management in relation to climate change. The first was geo-information technologies and their application for work in crisis situations, as well as sensor and communication networks and their roles for improving situational awareness. The second aspect was resilience, and its role and purpose across the entire cycle of disaster management, from pre-disaster preparedness to post-disaster recovery including challenges and opportunities in relation to rapid urbanisation and the role of security in improved disaster management practices.This volume consists of 16 peer-reviewed scientific papers. These were selected on the basis of double-blind review from among the 25 full papers submitted to the Gi4DM 2020 conference. Each paper was reviewed by three scientific reviewers. The authors of the papers were encouraged to revise, extend and adapt their papers to reflect the comments of the reviewers and fit the goals of this volume. The selected papers concentrate on monitoring and analysis of forest fire (3), landslides (3), flood (2), earthquake, avalanches, water pollution, heat, evacuation and urban sustainability, applying a variety of remote sensing, GIS and Web-based technologies. Figure 1 illustrates the scope of the covered topics though the word count of keywords and titles.The Gi4DM 2020 program consisted of scientific presentations, keynote speeches, panel discussions and tutorials. The four keynotes speakers Prof Suzan Cutter (Hazard and Vulnerability Research Institute, USC, US), Jeremy Fewtrell (NSW Fire and Rescue, Australia), Prof Orhan Altan (Ad-hoc Committee on RISK and Disaster Management, GeoUnions, Turkey) and Prof Philip Gibbins (Fenner School of Environment and Society, ANU, Australia) concentrated on different aspects of disaster and risk management in the context of climate change. Eight tutorials offered exciting workshops and hands-on on: Semantic web tools and technologies within Disaster Management, Structure-from-motion photogrammetry, Radar Remote Sensing, Dam safety: Monitoring subsidence with SAR Interferometry, Location-based Augmented Reality apps with Unity and Mapbox, Visualising bush fires datasets using open source, Making data smarter to manage disasters and emergency situational awareness and Response using HERE Location Services. The scientific sessions were blended with panel discussions to provide more opportunities to exchange ideas and experiences, connect people and researchers from all over the world.The editors of this volume acknowledge all members of the scientific committee for their time, careful review and valuable comments: Abdoulaye Diakité (Australia), Alexander Rudloff (Germany), Alias Abdul Rahman (Malaysia), Alper Yilmaz (USA), Amy Parker (Australia), Ashraf Dewan (Australia), Bapon Shm Fakhruddin (New Zealand), Batuhan Osmanoglu (USA), Ben Gorte (Australia), Bo Huang (Hong Kong), Brendon McAtee (Australia), Brian Lee (Australia), Bruce Forster (Australia), Charity Mundava (Australia), Charles Toth (USA), Chris Bellman (Australia), Chris Pettit (Australia), Clive Fraser (Australia), Craig Glennie (USA), David Belton (Australia), Dev Raj Paudyal (Australia), Dimitri Bulatov (Germany), Dipak Paudyal (Australia), Dorota Iwaszczuk (Germany), Edward Verbree (The Netherlands), Eliseo Clementini (Italy), Fabio Giulio Tonolo (Italy), Fazlay Faruque (USA), Filip Biljecki (Singapore), Petra Helmholz (Australia), Francesco Nex (The Netherlands), Franz Rottensteiner (Germany), George Sithole (South Africa), Graciela Metternicht (Australia), Haigang Sui (China), Hans-Gerd Maas (Germany), Hao Wu (China), Huayi Wu (China), Ivana Ivanova (Australia), Iyyanki Murali Krishna (India), Jack Barton (Australia), Jagannath Aryal (Australia), Jie Jiang (China), Joep Compvoets (Belgium), Jonathan Li (Canada), Kourosh Khoshelham (Australia), Krzysztof Bakuła (Poland), Lars Bodum (Denmark), Lena Halounova (Czech Republic), Madhu Chandra (Germany), Maria Antonia Brovelli (Italy), Martin Breunig (Germany), Martin Tomko (Australia), Mila Koeva (The Netherlands), Mingshu Wang (The Netherlands), Mitko Aleksandrov (Australia), Mulhim Al Doori (UAE), Nancy Glenn (Australia), Negin Nazarian (Australia), Norbert Pfeifer (Austria), Norman Kerle (The Netherlands), Orhan Altan (Turkey), Ori Gudes (Australia), Pawel Boguslawski (Poland), Peter van Oosterom (The Netherlands), Petr Kubíček (Czech Republic), Petros Patias (Greece), Piero Boccardo (Italy), Qiaoli Wu (China), Qing Zhu (China), Riza Yosia Sunindijo (Australia), Roland Billen (Belgium), Rudi Stouffs (Singapore), Scott Hawken (Australia), Serene Coetzee (South Africa), Shawn Laffan (Australia), Shisong Cao (China), Sisi Zlatanova (Australia), Songnian Li (Canada), Stephan Winter (Australia), Tarun Ghawana (Australia), Ümit Işıkdağ (Turkey), Wei Li (Australia), Wolfgang Reinhardt (Germany), Xianlian Liang (Finland) and Yanan Liu (China).The editors would like to express their gratitude to all contributors, who made this volume possible. Many thanks go to all supporting organisations: ISPRS, SSSI, URAP2, Blackash, Mercury and ISPRS Journal of Geoinformation. The editors are grateful to the continued support of the involved Universities: The University of New South Wales, Curtin University, Australian National University and The University of Melbourne.

<p><strong>List of abstracts and authors:</strong></p><p><strong>1. Antipsychotics in anxiety disorders</strong></p><p>Christer Allgulander</p><p><strong>2. Anxiety in somatic disorders</strong></p><p>Christer Allgulander</p><p><strong>3. Community rehabilitation of the schizophrenic patient</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera</p><p><strong>4. Dual diagnosis: A theory-driven multidisciplinary approach for integrative care</strong></p><p>David Blackbeard</p><p><strong>5. The emotional language of the gut - when 'psyche' meets 'soma'</strong></p><p>Helen Clark</p><p><strong>6. The Psychotherapy of bipolar disorder</strong></p><p>Franco Colin</p><p><strong>7. The Psychotherapy of bipolar disorder</strong></p><p>Franco Colin</p><p><strong>8. Developing and adopting mental health policies and plans in Africa: Lessons from South Africa, Uganda and Zambia</strong></p><p>Sara Cooper, Sharon Kleintjes, Cynthia Isaacs, Fred Kigozi, Sheila Ndyanabangi, Augustus Kapungwe, John Mayeya, Michelle Funk, Natalie Drew, Crick Lund</p><p><strong>9. The importance of relapse prevention in schizophrenia</strong></p><p>Robin Emsley</p><p><strong>10. Mental Health care act: Fact or fiction?</strong></p><p>Helmut Erlacher, M Nagdee</p><p><strong>11. Does a dedicated 72-hour observation facility in a district hospital reduce the need for involuntary admissions to a psychiatric hospital?</strong></p><p>Lennart Eriksson</p><p><strong>12. The incidence and risk factors for dementia in the Ibadan study of ageing</strong></p><p>Oye Gureje, Lola Kola, Adesola Ogunniyi, Taiwo Abiona</p><p><strong>13. Is depression a disease of inflammation?</strong></p><p><strong></strong>Angelos Halaris</p><p><strong>14. Paediatric bipolar disorder: More heat than light?</strong></p><p>Sue Hawkridge</p><p><strong>15. EBM: Anova Conundrum</strong></p><p>Elizabeth L (Hoepie) Howell</p><p><strong>16. Tracking the legal status of a cohort of inpatients on discharge from a 72-hour assessment unit</strong></p><p>Bernard Janse van Rensburg</p><p><strong>17. Dual diagnosis units in psychiatric facilities: Opportunities and challenges</strong></p><p>Yasmien Jeenah</p><p><strong>18. Alcohol-induced psychotic disorder: A comparative study on the clinical characteristics of patients with alcohol dependence and schizophrenia</strong></p><p>Gerhard Jordaan, D G Nel, R Hewlett, R Emsley</p><p><strong>19. Anxiety disorders: the first evidence for a role in preventive psychiatry</strong></p><p>Andre F Joubert</p><p><strong>20. The end of risk assessment and the beginning of start</strong></p><p>Sean Kaliski</p><p><strong>21. Psychiatric disorders abd psychosocial correlates of high HIV risk sexual behaviour in war-effected Eatern Uganda</strong></p><p>E Kinyada, H A Weiss, M Mungherera, P Onyango Mangen, E Ngabirano, R Kajungu, J Kagugube, W Muhwezi, J Muron, V Patel</p><p><strong>22. One year of Forensic Psychiatric assessment in the Northern Cape: A comparison with an established assessment service in the Eastern Cape</strong></p><p>N K Kirimi, C Visser</p><p><strong>23. Mental Health service user priorities for service delivery in South Africa</strong></p><p>Sharon Kleintjes, Crick Lund, Leslie Swartz, Alan Flisher and MHaPP Research Programme Consortium</p><p><strong>24. The nature and extent of over-the-counter and prescription drug abuse in cape town</strong></p><p>Liezl Kramer</p><p><strong>25. Physical health issues in long-term psychiatric inpatients: An audit of nursing statistics and clinical files at Weskoppies Hospital</strong></p><p>Christa Kruger</p><p><strong>26. Suicide risk in Schizophrenia - 20 Years later, a cohort study</strong></p><p>Gian Lippi, Ean Smit, Joyce Jordaan, Louw Roos</p><p><strong>27.Developing mental health information systems in South Africa: Lessons from pilot projects in Northern Cape and KwaZulu-Natal</strong></p><p>Crick Lund, S Skeen, N Mapena, C Isaacs, T Mirozev and the Mental Health and Poverty Research Programme Consortium Institution</p><p><strong>28. Mental health aspects of South African emigration</strong></p><p>Maria Marchetti-Mercer</p><p><strong>29. What services SADAG can offer your patients</strong></p><p>Elizabeth Matare</p><p><strong>30. Culture and language in psychiatry</strong></p><p>Dan Mkize</p><p><strong>31. Latest psychotic episode</strong></p><p>Povl Munk-Jorgensen</p><p><strong>32. The Forensic profile of female offenders</strong></p><p>Mo Nagdee, Helmut Fletcher</p><p><strong>33. The intra-personal emotional impact of practising psychiatry</strong></p><p>Margaret Nair</p><p><strong>34. Highly sensitive persons (HSPs) and implications for treatment</strong></p><p>Margaret Nair</p><p><strong>35. Task shifting in mental health - The Kenyan experience</strong></p><p>David M Ndetei</p><p><strong>36. Bridging the gap between traditional healers and mental health in todya's modern psychiatry</strong></p><p>David M Ndetei</p><p><strong>37. Integrating to achieve modern psychiatry</strong></p><p>David M Ndetei</p><p><strong>38. Non-medical prescribing: Outcomes from a pharmacist-led post-traumatic stress disorder clinic</strong></p><p>A Parkinson</p><p><strong>39. Is there a causal relationship between alcohol and HIV? Implications for policy, practice and future research</strong></p><p>Charles Parry</p><p><strong>40. Global mental health - A new global health discipline comes of age</strong></p><p>Vikram Patel</p><p><strong>41. Integrating mental health into primary health care: Lessons from pilot District demonstration sites in Uganda and South Africa</strong></p><p>Inge Petersen, Arvin Bhana, K Baillie and MhaPP Research Programme Consortium</p><p><strong>42. Personality disorders -The orphan child in axis I - Axis II Dichotomy</strong></p><p><strong></strong>Willie Pienaar</p><p><strong>43. Case Studies in Psychiatric Ethics</strong></p><p>Willie Pienaar</p><p><strong>44. Coronary artery disease and depression: Insights into pathogenesis and clinical implications</strong></p><p>Janus Pretorius</p><p><strong>45. Impact of the Mental Health Care Act No. 17 of 2002 on designated hospitals in KwaZulu-Natal: Triumphs and trials</strong></p><p>Suvira Ramlall, Jennifer Chipps</p><p><strong>46. Biological basis of addication</strong></p><p>Solomon Rataemane</p><p><strong>47. Genetics of Schizophrenia</strong></p><p>Louw Roos</p><p><strong>48. Management of delirium - Recent advances</strong></p><p>Shaquir Salduker</p><p><strong>49. Social neuroscience: Brain research on social issues</strong></p><p>Manfred Spitzer</p><p><strong>50. Experiments on the unconscious</strong></p><p>Manfred Spitzer</p><p><strong>51. The Psychology and neuroscience of music</strong></p><p>Manfred Spitzer</p><p><strong>52. Mental disorders in DSM-V</strong></p><p>Dan Stein</p><p><strong>53. Personality, trauma exposure, PTSD and depression in a cohort of SA Metro policemen: A longitudinal study</strong></p><p>Ugashvaree Subramaney</p><p><strong>54. Eating disorders: An African perspective</strong></p><p>Christopher Szabo</p><p><strong>55. An evaluation of the WHO African Regional strategy for mental health 2001-2010</strong></p><p>Thandi van Heyningen, M Majavu, C Lund</p><p><strong>56. A unitary model for the motor origin of bipolar mood disorders and schizophrenia</strong></p><p>Jacques J M van Hoof</p><p><strong>57. The origin of mentalisation and the treatment of personality disorders</strong></p><p>Jacques J M Hoof</p><p><strong>58. How to account practically for 'The Cause' in psychiatric diagnostic classification</strong></p><p>C W (Werdie) van Staden</p><p><strong>POSTER PRESENTATIONS</strong></p><p><strong>59. Problem drinking and physical and sexual abuse at WSU Faculty of Health Sciences, Mthatha, 2009</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera, E, N Kwizera, J L Bernal Munoz</p><p><strong>60. Prevalence of alcohol drinking problems and other substances at WSU Faculty of Health Sciences, Mthatha, 2009</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera, E, N Kwizera, J L Bernal Munoz</p><p><strong>61. Lessons learnt from a modified assertive community-based treatment programme in a developing country</strong></p><p>Ulla Botha, Liezl Koen, John Joska, Linda Hering, Piet Ooosthuizen</p><p><strong>62. Perceptions of psychologists regarding the use of religion and spirituality in therapy</strong></p><p>Ottilia Brown, Diane Elkonin</p><p><strong>63. Resilience in families where a member is living with schizophreni</strong></p><p>Ottilia Brown, Jason Haddad, Greg Howcroft</p><p><strong>64. Fusion and grandiosity - The mastersonian approach to the narcissistic disorder of the self</strong></p><p>William Griffiths, D Macklin, Loray Daws</p><p><strong>65. Not being allowed to exist - The mastersonian approach to the Schizoid disorder of the self</strong></p><p>William Griffiths, D Macklin, Loray Daws</p><p><strong>66. Risky drug-injecting behaviours in Cape Town and the need for a needle exchange programme</strong></p><p>Volker Hitzeroth</p><p><strong>67. Neuroleptic malignant syndrome in adolescents in the Western Cape: A case series</strong></p><p>Terri Henderson</p><p><strong>68. Experience and view of local academic psychiatrists on the role of spirituality in South African specialist psychiatry, compared with a qualitative analysis of the medical literature</strong></p><p>Bernard Janse van Rensburg</p><p><strong>69. The role of defined spirituality in local specialist psychiatric practice and training: A model and operational guidelines for South African clinical care scenarios</strong></p><p>Bernard Janse van Rensburg</p><p><strong>70. Handedness in schizophrenia and schizoaffective disorder in an Afrikaner founder population</strong></p><p>Marinda Joubert, J L Roos, J Jordaan</p><p><strong>71. A role for structural equation modelling in subtyping schizophrenia in an African population</strong></p><p>Liezl Koen, Dana Niehaus, Esme Jordaan, Robin Emsley</p><p><strong>72. Caregivers of disabled elderly persons in Nigeria</strong></p><p>Lola Kola, Oye Gureje, Adesola Ogunniyi, Dapo Olley</p><p><strong>73. HIV Seropositivity in recently admitted and long-term psychiatric inpatients: Prevalence and diagnostic profile</strong></p><p>Christina Kruger, M P Henning, L Fletcher</p><p><strong>74. Syphilis seropisitivity in recently admitted longterm psychiatry inpatients: Prevalence and diagnostic profile</strong></p><p>Christina Kruger, M P Henning, L Fletcher</p><p><strong>75. 'The Great Suppression'</strong></p><p>Sarah Lamont, Joel Shapiro, Thandi Groves, Lindsey Bowes</p><p><strong>76. Not being allowed to grow up - The Mastersonian approach to the borderline personality</strong></p><p>Daleen Macklin, W Griffiths</p><p><strong>77. Exploring the internal confirguration of the cycloid personality: A Rorschach comprehensive system study</strong></p><p>Daleen Macklin, Loray Daws, M Aronstam</p><p><strong>78. A survey to determine the level of HIV related knowledge among adult psychiatric patients admitted to Weskoppies Hospital</strong></p><p><strong></strong> T G Magagula, M M Mamabolo, C Kruger, L Fletcher</p><p><strong>79. A survey of risk behaviour for contracting HIV among adult psychiatric patients admitted to Weskoppies Hospital</strong></p><p>M M Mamabolo, T G Magagula, C Kruger, L Fletcher</p><p><strong>80. A retrospective review of state sector outpatients (Tara Hospital) prescribed Olanzapine: Adherence to metabolic and cardiovascular screening and monitoring guidelines</strong></p><p>Carina Marsay, C P Szabo</p><p><strong>81. Reported rapes at a hospital rape centre: Demographic and clinical profiles</strong></p><p>Lindi Martin, Kees Lammers, Donavan Andrews, Soraya Seedat</p><p><strong>82. Exit examination in Final-Year medical students: Measurement validity of oral examinations in psychiatry</strong></p><p>Mpogisheng Mashile, D J H Niehaus, L Koen, E Jordaan</p><p><strong>83. Trends of suicide in the Transkei region of South Africa</strong></p><p>Banwari Meel</p><p><strong>84. Functional neuro-imaging in survivors of torture</strong></p><p>Thriya Ramasar, U Subramaney, M D T H W Vangu, N S Perumal</p><p><strong>85. Newly diagnosed HIV+ in South Africa: Do men and women enroll in care?</strong></p><p>Dinesh Singh, S Hoffman, E A Kelvin, K Blanchard, N Lince, J E Mantell, G Ramjee, T M Exner</p><p><strong>86. Diagnostic utitlity of the International HIC Dementia scale for Asymptomatic HIV-Associated neurocognitive impairment and HIV-Associated neurocognitive disorder in South Africa</strong></p><p>Dinesh Singh, K Goodkin, D J Hardy, E Lopez, G Morales</p><p><strong>87. The Psychological sequelae of first trimester termination of pregnancy (TOP): The impact of resilience</strong></p><p>Ugashvaree Subramaney</p><p><strong>88. Drugs and other therapies under investigation for PTSD: An international database</strong></p><p>Sharain Suliman, Soraya Seedat</p><p><strong>89. Frequency and correlates of HIV Testing in patients with severe mental illness</strong></p><p>Hendrik Temmingh, Leanne Parasram, John Joska, Tania Timmermans, Pete Milligan, Helen van der Plas, Henk Temmingh</p><p><strong>90. A proposed mental health service and personnel organogram for the Elizabeth Donkin psychiatric Hospital</strong></p><p>Stephan van Wyk, Zukiswa Zingela</p><p><strong>91. A brief report on the current state of mental health care services in the Eastern Cape</strong></p><p>Stephan van Wyk, Zukiswa Zingela, Kiran Sukeri, Heloise Uys, Mo Nagdee, Maricela Morales, Helmut Erlacher, Orlando Alonso</p><p><strong>92. An integrated mental health care service model for the Nelson Mandela Bay Metro</strong></p><p>Stephan van Wyk, Zukiswa Zingela, Kiran Sukeri</p><p><strong>93. Traditional and alternative healers: Prevalence of use in psychiatric patients</strong></p><p>Zukiswa Zingela, S van Wyk, W Esterhuysen, E Carr, L Gaauche</p>

The cardiac surgery is the youngest surgical specialty that has emerged in the early period of the 20th century. Surprisingly, however, it is also the first surgical specialty that seems to be the first to disappear in a way or another in the second half of the 21st century. Even if the optimists consider this will never happen, it is expected that cardiac surgery will suffer a radical metamorphosis, which makes the realists say that this field of surgery will actually disappear.Before the beginning of the 20th century, the surgeons around the world have been convinced that human heart is untouchable. Remarkable surgeons of the 19th century like Theodor Billroth – the founder of the Viennese school of surgery- said in 1863 that “ Any surgeon that dares to perform surgery on the heart will fail and will lose the appreciation of his colleagues” [1]. This statement reveals the general opinion of that time, that the human heart is the center of the soul, of life itself and therefore it should never be touched. Considering this, Sharman stated in 1902 in „The American Journal of Medical Association” : “even though the heart lies at a few centimeters beneath the skin, it took 2400 years for surgery to reach this distance” [2].Ironically, the same year that English surgeon Stephan Paget stated that “probably the human heart is boundary that nature set for any kind of surgery -1896- was also the year when Ludwig Rehn, a German surgeon from Frankfurt, managed to successfully repair a right ventricular wound, signing the birth certificate of the cardiac surgery [3]. Since then the myth that the human heart can’t be touched by surgeons vanished and the sacred center of the heart has been opened…Two distinct periods of cardiac surgery can be identified over the next 100 years. The first period is the so called “surgery on a closed heart”, before the invention of extracorporeal circulation. In this heroic period, the first interventions that involved the pericardium were performed.In the first years of the 20th century, Alexis Carell imagined the experimental basis of cardio-vascular surgery. He invented the vascular sutures, demonstrated the possibility of organ transplantation and imagined coronary surgery. As recognition of his fundamental work he received the Nobel prize for medicine and physiology in 1912. Although he never performed surgery on humans, Alexis Carell remains to this day the first surgeon in history that was awarded with this prestigious prize [4].Surgery of the pericardium started in 1920 with Ludwig Rehn and Ferdinand Sauerbruch [5]. The first surgical approach of the aortic valve was realized by Theodor Tyffier in Paris in 1912 [6]. He succeeded to enlarge an aortic stenosis through a purse on the anterior wall of the aorta. In 1923, in Boston, USA, Elliot Cuttler realized the first instrumental mitral valve valvulotomy on a 12 year old girl [7]. Using a specially modified forceps, and the apex of the left ventricle as the initial approach, he managed to successfully open the mitral valve commissures and then to close the incision on the left ventricle. The first digital mitral valve commissurotomy through the left appendage was performed in 1925 by Sir Henry Soutar[8]. Catastrophic results ( 90% mortality) lead surgeons to abandon this procedure for the next 25 years. In 1948, Charles P. Bailey (Philadelphia), Dwight E. Harken (Boston) and Russell Brock (London) realized the first successful mitral valve commissurotomy [9,10].The first ligature of patent arterial duct was performed by Robert Edward Gross. This procedure took place at Harvard Medical School and Children’s Hospital from Boston, Massachusetts, in 1938 [11].Palliative treatment of the Fallot tetralogy started with the first systemic-pulmonary shunt,realized by Alfred Blalock in 1944 at John Hopkins Hospital [12]. The idea of subclavio-pulmonaryanastomosis was born with the contribution of Hellen Taussig, founder of pediatric cardiology.Treatment of aortic coarctation was independently realized by Edward Gross and Clarance Crafoord in 1945. Both surgeons managed to excised the diseased segment of the aorta and then performed an end to end anastomosis of the aorta [13].Sir Thomas Holmes-Sellors in 1947 and Russel Brock in 1948 realized the first pulmonary valvevalvulotomy [10].In our country, professor Nicolae Hortolomei was the first to perform surgery on the heart atColtea Hospital. He legated a patent arterial duct, excised an aortic coarctation and successfullyrealized in 1953 a digitally mitral valve commissurotomy [14].The second period of cardiac surgery began with the developing of the extracorporeal circulation.This technology allowed stopping the heart and keeping the patient alive, using a device thatmanage to circulate and oxygenate the blood. This ensemble composed of a pomp and anoxygenator was called “the extracorporeal circulation machine” and made possible the future development of “open cardiac surgery”.In 1946 Wilfred G. Bigelow (Toronto, Canada ), demonstrated the role of hypothermia inincreasing the tissue resistance to hypoxemia. This concept is fundamental in the development of extracorporeal circulation [15]. The first procedure on an open heart was realized by John Lewis from University of Minnesota, Mineapolis USA, on 2 september 1952. He used profund hypotermia and occlusion of the caval veins, without using extracorporeal circulation. Using this technique he closed an interatrial septal defect in a 6 year old boy. Time was his biggest limitation, because the heart could not be stoped for more than 8-10 minutes.On 6 may 1953, John H. Gibbon realised the first open heart surgery using an extracorporealcirculation machine [16]. He succesfully closed and interatrial septal deffect on an 18 years old girl.Unfortunatly he lost the following 4 patients, and he decided to abandon this king of surgery after20 years of research.A year later, on the 26th of March 1954 at „University of Minesotta” from Mineapolis USA, C.Walton Lillehei closed an inteventricluar septal defect on a child using the so called “crossedcirculation technique”. In this procedure, he connected the patient’s circulaton to his fathercirculation, trying to repoduce the fetal circulation [17]. Using this technique he operated 45patients, being the first surgeon that closed ventricular septal defects, corrected the commonatrioventricular canal and treated the Fallot tetralogy. Finding a compatible match for the “cross circulation” was the biggest limit of this technique. This method was untill the developement of liver and renal transplant, the only kind of surgery that could reach 200% mortality rate and was abandoned later due to ethical considerations.Starting from 1955, John Kirkling (Mayo Clinic), used the extracorporeal circulation machine(pomp - oxigenator) [18]. He used the Mayo-Gibbon-IBM type, and this technology began to beused all over the world.In Romania, the first surgical procedure on the heart using an extracorporeal circulation machinewas realized in 1961 at Fundeni Hospital (Bucharest). A remarkable team composed of professor Voinea Marinescu and professor Dan Setlacec, closed an atrial septal defect on an 18 years old boy.The extracorporeal machine was handled by Marian Ionescu, and the anesthesia was managed by professor George Litarczek. The patient is still living.Surgery of the cardiac valves started in 1960 when Albert Starr realized the first mitral valvereplacement [19].Without a doubt coronary artery bypass grafting is the most widly spread type of cardiac surgery.Initially introduced by Michael DeBakey and later perfected by Renee Favaloro in 1960, thisprocedure remains one of the most frequent and best studied type of surgery in medicine [20].A crucial moment in the history of cardiac surgery is represented by the first cardiac transplanton human performed by Christian Barnard in 1967[21]. This achievement consecrate cardiacsurgery as a high performace field and made the cardiac surgen a public figure. In this moment, thelove story between cardiac surgery and media started. Most probably the majority of active cardiac surgeons of this generation owe Christiaan Barnard their option for choosing this field and this medical specialty her huge succes.It is considered that the maximum moment of cardiac surgery is the year 1986 when worldwide over 2000 procedures on the open heart were performed daily.But new discoveries started to appear in the cardiovascular field. In the 70s percutaneous procedures were invented. Andreas Gruntzig realized in 1977 the first coronary angioplasty and coronary stents were implanted in 1986 by Puel and Sigwart. Development on interventional cardiology was exponential and nowadays at the European Association of Cardiothoracic Surgery simposium about the future of cardiac surgery, 90% of the cardiac surgeons stated that they would prefer the coronary stent over coronar artery bypass grafting surgery if they would have to choose as patients.Starting with 2003 when was realised the first transcatheter aortic valve implantation (TAVI), the exclusive field of cardiac valve surgery is partialy claimed by interventional cardiology [23].The field of aortic anevrisms and acute dissections falls from cardiac surgery also to interventional cardiology after the developement of endoaortic stent grafts [24,25].As a consequence the number of coronary artery bypass grating procedures falls 28% between 1997 and 2004 in the USA. Meanwhile coronary percutaneos procedures rises with 121% [24,28]. Also it is possible that for the first time in history, the number of cardiac surgeons will decrease untill 2020 [24.28].But cardiac surgery extends in to new fields in order to survive. For exemple, one of the future aspect is the treatment of cardiac insuffiency. It is estimated that over 5 milion americans have cardiac insuffiency [26] and cardiac transplantation is the solution for these patients. Unfortunately, the number of donors falls, and this is no longer an effective solution. Multiple devices are designed in order to help the heart, ranging from univentricular asist devices to artificial hearts. This devices can act as a bridge to cardiac transplantation or they can be the solution for patients that are not eligible for cardiac transplantation.Surgical treatment of atrial fibrilation remains a solid options for patients with this disease which have a high risk of emboly or progression to cardiac insufficiency [27].The field of corection of congenital cardiac malformations lessens because of early diagnostic and possibility to end the pregnancy. But there are surgical treatments for children that are born with complex congenital heart malformations with optimal results.The development of minimally invasive techniques, robotics and hybrid ones represents the response of cardiac surgery to interventional cardiology.Apparently, cardiac surgery and interventional cardiology are merging. More and more patients are heald in hybrind operating rooms, using hybrid techniques. The concept of “heart teams” emerges- a team made of cardiologists, cardiac surgeons and cardiac anesthesiologists. Probably, in the future will exist only a cardiologist-cardiac surgeon or a cardiac surgeon-cardiologist, either way a specialist in cardiovascular medicine.The conclusion isn’t pessimistic. As long as there will be patients, doctors will be needed. It remains to be seen if they will be surgeons, interventional cardiologists or just cardiologists.Certainly, general anesthesia, opeaning the mediastinum through median sternotomy using an electic saw and circulating the patients blood through the extracorporeal circulation machine, not to mention stopping the heart, isn’t the future.But introducing needls in arteries, wires in the aorta and pen sprins into the coronary isn’t also the future.Without a doubt, the future belongs to physicians that will cure cardiovascular disease with pills or even better just with advices...

Editors-in-Chief Graduate: Nicole Haldoupis Undergraduate: Caitilin TerflothSenior Editor, Health Sciences: Mariam GoubranAssociate Editors: Ashley Binta, Jamie Jinsoo Kim, Kristen Schott, Bahar BahraniGraduate Advisor: Chelsea CunninghamSenior Editor, Humanities and Fine Arts: Garret PifkoAssociate Editors: Kayden Gabriel Siriany Linares, Irteqa Khan, Renata Kisin, Erin Grant, Madison Taylor, Kaylee GuistSenior Editor, Interdisciplinary: Aimee FerreAssociate Editors: Emily Barlow, Nykole King, Tushita Patel, Brian VinetSenior Editor, Natural Sciences: Dakoda HermanAssociate Editors, Natural Sciences: Lavie Hoang Nguyen, Jeremy Young, Christina TollettGraduate Advisor: Rachel ParkinsonSenior Editor, Social Sciences: Courtney BallantyneAssociate Editors: Mitchell Barry, Rainer Kocsis, Lindsay Wileniec, Emma Bugg, Eric Gilliland, So Ri Lee, Michelle McLean, Whitney LoerzelGraduate Advisor: Jennifer SedgewickLayout Editor: Stephanie FuchsAssociate Editors: Michelle McLean, Lindsday WileniecMarketing and Communications: Veronica Stewart, with help from Erin Holcomb, Nicole Haldoupis, and Liv MarkenWebsite: Yashwanthan Manivannan and Liv Marken

Matthias Toplak: Kleidung und Tracht in der altnordischen Sagaliteratur und im archäologischen Fundkontext (Anita Sauckel: Greifswald, E-Mail: anita.sauckel@uni-greifswald.de)Arnulf Krause: Die wirkliche Mittelerde (Elisabeth Maria Magin: Göttingen, E-Mail: Elisabeth.Magin@gmx.de)Merrill Kaplan: Thou Fearful Guest (Julia Zernack: Frankfurt, E-Mail: Zernack@em.uni-frankfurt.de)Ebbe Volquardsen: Die Anfänge des grönländischen Romans (Ingo Sundmacher: Berlin, ingosundmacher@nordsprachen.de)Stephen Pax Leonard (Ed.): Language, Society and Identity in early Iceland (Michael Schulte: Kristiansand, E-Mail: michael.schulte@uia.no)Endre Mørck: 2011 Leddstillinga i mellomnorske heilsetninger (Erik Magnusson Petzell: Göteborg, E-Mail: Erik.Petzell@sofi.se)Julia Prentice: På rak sak (Roger Reidinger: Wien, E-Mail: roger.reidinger@univie.ac.at)Magdalena Bator (Ed.): Obsolete Scandinavian Loanwords in English (Michael Schulte: Kristiansand, E-Mail: Michael.schulte@uia.no)Stephan Michael Schröder: Ideale Kommunikation, reale Filmproduktion (Ulrik Lehrmann: Odense, E-Mail: lehrmann@sdu.dk)

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Zusammenfassung Frühe Neuzeit William Urban, Bayonets for Hire. Mercenaries at War, 1550-1789 (Stephan Theilig) Sein Feld war die Welt. Johann Moritz von Nassau-Siegen (1604-1679). Von Siegen über die Niederlande und Brasilien nach Brandenburg. Hrsg. von Gerhard Brunn und Cornelius Neutsch (Christian Senne) Maren Lorenz, Das Rad der Gewalt. Militär und Zivilbevölkerung in Norddeutschland nach dem Dreißigjährigen Krieg (1650-1700) (Martin Meier) Sven Externbrink, Friedrich der Große, Maria Theresia und das Alte Reich. Deutschlandbild und Diplomatie Frankreichs im Siebenjährigen Krieg (Marcus von Salisch) Franz Herre, George Washington. Präsident an der Wiege einer Weltmacht (Michael Peters) Brigitte Meier, Friedrich Wilhelm II. König von Preußen (1744-1797). Ein Leben zwischen Rokoko und Revolution (Marcus von Salisch) 1789-1870 J.E.O. Screen, The Army in Finland. During the Last Decades of Swedish Rule (1770-1809) (Agilolf Keßelring) Roman Töppel, Die Sachsen und Napoleon. Ein Stimmungsbild 1806-1813 (Marcus von Salisch) Michael V. Leggiere, The Fall of Napoleon, vol. 1: The Allied Invasion of France, 1813-1814 (Heinz Stübig) Ludwig Hassenpflug, Denkwürdigkeiten aus der Zeit des zweiten Ministeriums 1850-1855. Hrsg. von Ewald Grothe (Bernhard Sicken) Hilmar Sack, Der Krieg in den Köpfen. Die Erinnerung an den Dreißigjährigen Krieg in der deutschen Krisenerfahrung zwischen Julirevolution und deutschem Krieg (Andreas Rose)

The present article contemplates some reflections produced from the accumulation produced in our research group around a research project that sought to understand some practices of education developed by Brazilian communists, in periods in which they lived educational practices in or for clandestinity, particularly between the 1950s and 1970s.From the intersection between history of education and political culture, we present theoretical-methodological reflections on the autobiographical narratives that constituted the sources of ongoing research. The methodology is qualitative in nature and based on the presentation of notes that could serve as a motto for reflection about the use of narratives and their interfaces with the experience and the collective memory. The reflections carried out argue that the analysis of the narratives present in the autobiographical sources must consider some theoretical-methodological intersections from the (autobiographical) research perspective, as well as on memory and experience.ResumoO presente artigo contempla algumas reflexões produzidas a partir do acúmulo produzido em nosso grupo de pesquisa em torno de um projeto de investigação que buscou compreender algumas práticas de educação desenvolvidas por comunistas brasileiros, em períodos nos quais viveram práticas educativas na ou para a clandestinidade, particularmente entre as décadas de 1950 e 1970. A partir da intersecção entre história da educação e cultura política, apresentamos reflexões de cunho teórico-metodológico sobre as narrativas autobiográficas que constituíram as fontes da investigação em curso. A metodologia é de natureza qualitativa e se pauta na apresentação de algumas notas que possam servir de mote para a reflexão sobre o uso de narrativas e suas interfaces com a experiência e a memória coletiva. As reflexões realizadas defendem que a análise das narrativas presentes nas fontes autobiográficas deve considerar algumas intersecções teórico-metodológicas da perspectiva da pesquisa (auto)biográfica, bem como sobre memória e experiência.ResumenEl presente artículo contempla algunas reflexiones producidas a partir de la acumulación producida en nuestro grupo de investigación en torno a un proyecto de investigación que buscó comprender algunas prácticas educativas desarrolladas por comunistas brasileños, en períodos en los que vivieron prácticas educativas en o para la clandestinidad, en particular entre los años 1950 y 1970. Desde la intersección entre la historia de la educación y la cultura política, presentamos reflexiones teórico-metodológicas sobre las narrativas autobiográficas que constituyeron las fuentes de la investigación en curso. La metodología es de naturaleza cualitativa y se basa en la presentación de algunas notas que pueden servir como un lema para la reflexión sobre el uso de las narrativas y sus interfaces con la experiencia y la memoria colectiva. Las reflexiones sostenidas sostienen que el análisis de las narrativas presentes en las fuentes autobiográficas debe considerar algunas intersecciones teóricas y metodológicas desde la perspectiva de la investigación (biográfica), así como sobre la memoria y la experiencia.Palavras-chave: Educação clandestina, Experiência, Memória coletiva, Narrativas.Keywords: Clandestine education, Experience, Collective memory, Narratives.Palabras clave: Educación clandestina, Experiencia, Memoria colectiva, Narrativas.ReferencesABRAHÃO, Maria Helena Menna Barreto (Orgs.). Educadores Sul-Rio-Grandenses: muita vida nas histórias de vida. Porto Alegre: EDIPUCRS, 2008.ABRAHÃO, Maria Helena Menna Barreto. História e histórias de vida – destacados educadores fazem a história da educação rio-grandense. Porto Alegre: EDIPUCRS, 2001.ABRAHÃO, Maria Helena Menna Barreto. Pesquisa (auto)biográfica: tempo, memória e narrativas. In: ______ (Org.). A aventura (auto)biográfica – teoria e empiria. 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Erlebnisberichte, Fakten und Dokumente. Hrsg. von Bernd Biedermann und Hans-Georg Löffler Rüdiger Wenzke Marianna Dudley, An Environmental History of the UK Defence Estate, 1945 to the Present Michael Peters

SCHWERPUNKT CORONA-PANDEMIE Grenzenloser Infektionsschutz in der Corona-Krise? Konturen eines grundrechtssensiblen Pandemie-Krisenrechts 109 Stephan Rixen Notstandsverfassung und Corona-Virus. Rückblick und Ausblick 118 Jörn Ipsen „Zwangstracking“ – Ein rechtliches No-Go? 133 Christian Hamann Grundrechte unter Quarantäne? 139 Christoph Gusy AUFSÄTZE Großprojekte und Bürgerbeteiligung – ein Resumé 142 Patrick Schnieder Religion und Robe – Ein Widerspruch? 149 Noreen v. Schwanenflug und Susann Langer Geschäftsmäßig angebotene Suizidhilfe als neuer Wirtschaftszweig? Das Urteil des Bundesverfassungsgerichts zum selbstbestimmten Sterben und zur geschäftsmäßigen Förderung der Selbsttötung 156 Maximilian Chr. M. Möllers und Martin H. W. Möllers Das Recht auf Selbsttötung – Verfassungsrechtliche Begrenzung der Politik oder politische Betätigung des Verfassungsgerichts? Anmerkungen zu BVerfG, Urteil vom 26. Februar 2020 –2 BvR 2347/15 167 Sven Leif Erik Johannsen Wann ist eine Partei eine Partei? Untersuchungen der Entscheidungspraxis des Bundeswahlausschusses 175 Daniel Hellmann Nachrichtendienste im Spannungsfeld zwischen Wissenschaft und Praxis. Tagungsbericht zum 3. Symposium zum Recht der Nachrichtendienste 185 Christopher Giogios Karlsruhe und die EU-Grundrechtecharta: ein „europafeindlicher“ Rückfall hinter Solange II? Zu den Entscheidungen des Bundesverfassungsgerichts Recht auf Vergessen I und II 190 Robert Chr. van Ooyen Völkerrechtliche Impulse gegen Gewalt und Belästigung in der Arbeitswelt 200 Sonja Mangold JURIST IM PORTRÄT Georg Jellinek (1851– 1911): Jurist, Philosoph und Staatstheoretiker 207 Andreas Anter RECHTSPOLITISCHES AUS DEN USA Kontrolle des US-Präsidenten unmöglich? Zum gescheiterten Impeachment-Verfahren gegen Präsident Trump 211 Manfred H. Wiegandt BLOG DES QUARTALS / AUS DEM JUWISSBLOG Über die personelle und inhaltliche Verzahnung von Politik und Verfassungsrecht 215 Matthias K. Klatt GENDER UND RECHTSPOLITIK Istanbul-Konvention: Berücksichtigung vorheriger Gewalt in Sorge- und Umgangsverfahren (Artikel 31 IK) 220 Maria Wersig, Ulrike Lembke und Brigitte Meyer-Wehage BERICHTE UND INFORMATIONEN Rechtspolitisches aus Europa 223 Peter Schwarzburg Rechtspolitische Zeitschriftenumschau 2/2020 226 Christian Busse BUCHBESPRECHUNGEN Formen der Einordnung des Islam in das deutsche Religionsverfassungsrecht 232 Hermann Weber Lesenswert: Das Handbuch zum politischen Extremismus 236 Andreas Schwegel Solides Handwerk, aber ohne rechtspolitische Meinung 239 Hendrik Wassermann Lesenswert: Philip Adorfs Studie über die Republikanische Partei 241 Hendrik Wassermann NAMEN UND NACHRICHTEN Corona: Bayerischer Landtag beschließt Gesetz zu „Gesundheitsnotstand“ 155 Berlin: Ulrike Lembke neue Richterin am Verfassungsgerichtshof 166 Autoren dieses Heftes 244

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