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Relevant bibliographies by topics / Stereoselective analysis

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Academic literature on the topic 'Stereoselective analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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Journal articles on the topic "Stereoselective analysis"

1

Czerwenka, Christoph, and Wolfgang Lindner. "Stereoselective peptide analysis." Analytical and Bioanalytical Chemistry 382, no. 3 (2005): 599–638. http://dx.doi.org/10.1007/s00216-005-3091-x.

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Ružena, Čižmáriková, Valentová Jindra та Horáková Renáta. "Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis". Open Chemistry 18, № 1 (2020): 628–47. http://dx.doi.org/10.1515/chem-2020-0056.

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Abstractβ2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytica

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3

Guo, Wenna, Zhiyong Li, Meng Yuan, et al. "Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis." Biomolecules 10, no. 1 (2020): 112. http://dx.doi.org/10.3390/biom10010112.

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Chirality is a common phenomenon, and it is meaningful to explore interactions between stereoselective bio-macromolecules and chiral small molecules with preclinical and clinical significance. Protopanaxadiol-type ginsenosides are main effective ingredients in ginseng and are prone to biotransformation into a pair of ocotillol C20-24 epoxide epimers, namely, (20S,24S)-epoxy-dammarane-3,12,25-triol (24S-PDQ) and (20S,24R)-epoxy dammarane-3,12,25-triol (24R-PDQ) that display stereoselective fate in vivo. However, possible molecular mechanisms involved are still unclear. The present study aimed t

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4

Volland, Christine, Helen Sun, and Leslie Z. Benet. "Stereoselective analysis of fenoprofen and its metabolites." Journal of Chromatography B: Biomedical Sciences and Applications 534 (January 1990): 127–38. http://dx.doi.org/10.1016/s0378-4347(00)82155-6.

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5

Srinivas, N. R., W. C. Shyu, V. R. Shah, D. A. Campbell, and R. H. Barbhaiya. "Stereoselective analysis of nadolol in human plasma." Biomedical Chromatography 9, no. 5 (1995): 226–28. http://dx.doi.org/10.1002/bmc.1130090507.

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6

Juárez, Ernesto, Adriana García, Herbert Hommer, Magali Salas, and Barbara Gordillo. "Stereoselective synthesis and conformational analysis of aromaticC-thionucleosides." Heteroatom Chemistry 17, no. 4 (2006): 289–98. http://dx.doi.org/10.1002/hc.20205.

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7

Ducrot, Pierre, Robert Bucourt, Claude Thal, Bernard Marçot, Joëlle Mayrargue, and Henri Moskowitz. "Conformational analysis of stereoselective epoxidations in flexible systems." Tetrahedron 52, no. 19 (1996): 6699–704. http://dx.doi.org/10.1016/0040-4020(96)00320-1.

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8

Graham, Ronald J., and Larry Weiler. "The stereoselective alkylation and conformational analysis of 15-hexadecanolide." Tetrahedron Letters 32, no. 8 (1991): 1027–30. http://dx.doi.org/10.1016/s0040-4039(00)74478-9.

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9

Tangara, Salia, Alice Kanazawa, Martine Fayolle, et al. "Short synthesis, X-ray and conformational analysis of a cyclic peracetylated l-sorbose-derived nitrone, a useful intermediate towards N–O-containing d-gluco-iminosugars." New Journal of Chemistry 42, no. 20 (2018): 16735–43. http://dx.doi.org/10.1039/c8nj03868f.

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10

Hanquet, B., B. Tabyaoui, J. C. Caille, M. Farnier, and R. Guilard. "Synthèse stéréosélective de (±) boschnialactone, (±) 7-épiteucriumlactone et (±) 7-épiisoiridomyrmécine. Étude de la stéréochimie par spectroscopie de résonance magnétique nucléaire." Canadian Journal of Chemistry 68, no. 4 (1990): 620–27. http://dx.doi.org/10.1139/v90-095.

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The stereoselective syntheses of (±) boschnialactone 1, (±) 7-epiteucriumlactone 2, and (±) 7-epiisoiridomyrmecine 3 are described. Their preparation involved Stetter's reaction followed by nucleophilic addition of lithium enolates of suitable esters. Silylated reagents are used in the lactonisation step and the observed yields are between 63 and 78%. The proposed structural analysis is not in accord with the results of a previous study. The nuclear magnetic resonance data are determined using ID and 2D proton and carbon NMR experiments. Keywords: stereoselective synthesis, boschnialactone, 7-

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Dissertations / Theses on the topic "Stereoselective analysis"

1

彭君華 and Kwan-wah Pang. "Studies toward stereoselective total synthesis of triptolide." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B3121454X.

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2

Igwemezie, Linus Nnamdi. "Stereoselective HPLC analysis, pharmacokinetics, tissue distribution and pharmacodynamics of mexiletine enantiomers." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/30655.

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Mexiletine [(2',6'-dimethylphenoxy)-2-amino propane] is a class 1 antiarrhythmic agent with a similar chemical structure and electrophysiological effects to those of lidocaine. It is a chiral drug which is used clinically in the racemic form (i.e. 50:50 ratio of two enantiomers). This thesis describes the stereoselective HPLC analysis, pharmacokinetics, tissue distribution and pharmacodynamics of mexiletine enantiomers. The development of a highly sensitive and stereoselective HPLC assay for mexiletine enantiomers, using 2-anthroyl chloride as a derivatization reagent, was attempted. The synt

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Igwemezie, Linus Nnamdi. "Stereoselective HPLC analysis of mexiletine enantiomers : pharmacokinetics and protein binding in humans." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/25901.

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Mexiletine is a relatively new class IB antiarrhythmic agent, similar in structure and pharmacological effects to lidocaine. It is effective mainly against ventricular arrhythmias and can be administered by the oral route, mexiletine is a chiral drug which is used clinically as the racemic mixture. The enantiomers of numerous chiral drugs have been shown to differ in their disposition in the body due to their stereoselective pharmacodynamic and/or pharmacokinetic properties. The relative antiarrhythmic potencies of the individual enantiomers of mexiletine have not been studied, nor have their

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4

Kwok, David W. K. "Stereoselective HPLC analysis, pharmacokinetics, serum protein binding and metabolism of mexiletine enantiomers in healthy human subjects." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30850.

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Mexiletine (MexitilR) is an orally effective antiarrhythmic drug used clinically as a racemate of the R(-)- and S(+)-enantiomers. A stereoselective high-performance liquid chromatographic assay was developed for the determination of mexiletine enantiomers in serum, saliva, red blood cells and urine. The mexiletine enantiomers were resolved as their N-anthroyl derivatives on a PirkleR phenylglycine ionic chiral HPLC column. The present study examined the serum free (unbound) and total drug kinetics for the mexiletine enantiomers in twelve healthy volunteers following oral administration of 200

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5

Borges, Keyller Bastos. "Análise estereosseletiva da tioridazina e seus principais metabólitos: um estudo cinético de biotransformação empregando fungos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-02102008-164814/.

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BORGES, K. B. Análise estereosseletiva da tioridazina e seus principais metabólitos: um estudo cinético de biotransformação empregando fungos. 2006. 124f. Dissertação (Mestrado) Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2006. Atualmente, existe um grande interesse em estudar a biotransformação estereosseletiva de fármacos, incluindo os processos que reproduzem as vias de metabolização in vivo. Alguns desses estudos estão sendo realizados empregando microrganismos como, por exemplo, fungos. A cromatografia líquida de alta eficiência é um

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Borges, Keyller Bastos. "Análise estereosseletiva de fármacos com aplicação em estudos de biotransformação empregando fungos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-29092010-160330/.

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Este trabalho teve por finalidade o desenvolvimento e validação de métodos para análise estereosseletiva de alguns fármacos e metabólitos, bem como a aplicação desses métodos na avaliação do potencial de fungos, principalmente endofíticos, em processos de biotransformação. Os seguintes fármacos foram selecionados para esse estudo: fluoxetina, propranolol, omeprazol, oxibutinina e ibuprofeno. Para determinação simultânea dos enantiômeros da fluoxetina (FLX) e norfluoxetina (NFLX) em meios de cultura de fungos endofíticos, empregou-se a cromatografia líquida de alta eficiência com detecção por

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7

Oliveira, Anderson Rodrigo Moraes de. "Técnicas de microextração aplicadas à análise estereosseletiva do ibuprofeno, da hidroxicloroquina e de seus metabólitos em urina." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-23072007-155100/.

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A análise estereosseletiva tem um lugar de destaque em várias áreas e, dentre elas, a farmacêutica, pois diversos fármacos quirais são comercializados como misturas racêmicas. A análise estereosseletiva empregando a cromatografia líquida de alta eficiência e a eletroforese capilar é prática e bastante eficaz para aplicações que envolvem a determinação de enantiômeros ao nível de traços em matrizes complexas, como por exemplo, em estudos de disposição cinética. Entretanto, devido à complexidade das matrizes biológicas, há necessidade da preparação da amostra antes de sua análise. Entre as dive

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8

LE, COZ LINDA. "Contribution a l'etude de la reaction d'imino diels-alder : syntheses stereoselectives et enantioselectives et analyses conformationnelles de phenyl-2 decahydroquinolein-4-ones a jonction de cycle cis et trans." Paris 11, 1990. http://www.theses.fr/1990PA112129.

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Dans cette these, nous reportons la synthese stereoselective et enantioselective de 2-phenyldecahydroquinolein-4-ones a jonction de cycle cis et trans par une reaction d'imino diels-alder entre l'ether d'enol trimethylsilylique de l'acetyl-1 cyclohexene et des c-phenylimines n-substituees en presence d'acides de lewis. Dans le premier chapitre, nous avons etudie l'influence de substituants electrodonneurs en position para du cycle aromatique porte par l'azote sur le deroulement de la reaction et sur la conformation des cetones obtenues. L'etude conformationnelle des 2-phenyldecahydroquinolein-

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9

Houdier, Stéphane. "Cycloisomaltodextrines : synthèse, stéréosélectivité, analyse conformationnelle." Grenoble 1, 1993. http://www.theses.fr/1993GRE10046.

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Au cours de ce travail nous avons prepare les premieres cycloisomaltodextrines (cid) possedant un enchainement glycosidique de type alpha (1-6) et composes analogues des cyclodextrines naturelles (cd). Les tri, tetra, et hexasaccharides cycliques symetriques perbenzyles ont ete synthetises. Deux autres composes cycliques (di et tri), mais non symetriques, ont egalement ete isoles. Amelioration de la stereoselectivite dans la glycosylation par la methode de fraser-reid et coll. Et modification de la methode de mukaiyama et coll. Ont ete les points de departs de cette synthese. Malgre la nature

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10

Clohs, Lilian. "Stereoselective high-performance liquid chromatography and capillary electrophoresis analysis and in vitro study of the serum protein binding of carvedilol enantiomers." Thesis, 1997. http://hdl.handle.net/2429/6605.

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Carvedilol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2- propanol, is a new antihypertensive drug which has recently been introduced on the market in Canada under the trade name, COREG. It contains a chiral centre in its structure and therefore exists as two enantiomers. The drug is marketed as the racemate, however, the two enantiomers possess different pharmacological actions. (-)-(S)-Carvedilol is a much more potent Pi-blocker than (+)-(R)-carvedilol, whereas both enantiomers exhibit the same oci-adrenergic antagonism. This study consisted of the development of sen

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Books on the topic "Stereoselective analysis"

1

Rahman, Atta-ur. Stereoselective synthesis. Elsevier, 1996.

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2

Atta-Ur-Rahman. Studies in Natural Product Chemistry : Stereoselective Synthesis, Part I. Elsevier Science Publishing Company, 1994.

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3

Atta-Ur-Rahman. Studies in Natural Product Chemistry : Stereoselective Synthesis, Part J (Studies in Natural Products Chemistry). Elsevier Science Pub Co, 1995.

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4

Atta-Ur-Rahman. Studies in Natural Product Chemistry : Stereoselective Synthesis, Part K (Studies in Natural Products Chemistry, Volume 18). Elsevier Science, 1996.

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