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Dissertations / Theses on the topic 'Stereoselective reaction'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Millet, Julien. "Approaches towards a stereoselective Nicholas reaction." Thesis, Kingston University, 2006. http://eprints.kingston.ac.uk/20379/.

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This programme of work has focused on developing ways of inducing stereoselectivity into the Nicholas reaction towards the synthesis of natural products. The first chapter of the thesis reviews the developments ofthe Nicholas reaction since its discovery in 1972 as well as other applications of cobalt clusters. The following chapter describes chirality and various approaches towards asymmetric synthesis. Chapter 3 details our investigations as well as the results that we achieved in the two ' areas we explored. The first part of the project attempted to determine which oxazolidinone derivative

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2

Rutherford, Alistair Peter. "Stereoselective synthesis of #Beta#-hydroxycyclohexanones using the anionic oxy-cope rearrangement." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299981.

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3

LOPS, CARMINE. "Development of organocatalytic and stereoselective reactions." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2918472.

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Il focus di questo dottorato è stato lo sviluppo di due reazioni organocatalitiche e stereoselettive: le addizioni di sulfa-Michael e le condensazioni di Darzens poiché rappresentano degli approcci sintetici interessanti per la sintesi di farmaci chirali e, nell’ambito farmaceutico, ci sono pochi principi attivi (API) sintetizzati con reazioni di SMAs e/o di Darzens organocatalitiche e stereoselettive. Nell’ambito delle addizioni di sulfa-Michael (SMAs), la catalisi mediata da molecole bifunzionali donatrici di legami ad idrogeno (HBD) rappresenta un approccio interessante per l'attivazione si

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4

Thomas, Jermaine D. O. "Highly regio and stereoselective hydroxy-directed Diels-Alder reaction." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6123.

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The Diels-Alder reaction has proven to be an invaluable tool in the arsenal of the synthetic organic chemist for the relatively facile construction of cyclic cores. However, the utility of this reaction is not without its shortcomings. Lack of regio and stereoselectivity are two problems that are often encountered with asymmetric dienophiles. Although Lewis acids have been successfully employed to control the selectivity of Diels-Alder reactions involving activated dienophiles, there is little precedent in the literature for their use with dienes containing a tertiary alcohol functionality, du

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5

Dawson, Graham John. "Studies on the stereoselective palladium-catalysed allylic substitution reaction." Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/31866.

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This thesis contains the preparation of a new design of ligand for the palladium catalysed allylic substitution reaction. The phosphine oxazoline ligands detailed in the thesis give high levels of enantiocontrol when used in conjunction with symmetrical allyl systems in the palladium catalysed allylic substitution reaction. For unsymmetrical allyl systems the palladium catalysed allylic substitution process proceeds with complete regiocontrol and high levels of stereocontrol are again observed. The products from the palladium catalysed allylic substitution reaction can be readily converted to

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6

Beligny, Samuel Daniel Charles. "Stereoselective synthesis of tetrahydropyridines using the Diels-Alder reaction." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414751.

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7

Takano, Toshiyuki. "SYNTHESIS OF CELLO-OLIGOSACCHARIDES -INFLUENCE OF SUBSTITUENT GROUPS ON STEREOSELECTIVE GLYCOSYLATION REACTION-." Kyoto University, 1990. http://hdl.handle.net/2433/78226.

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8

Cresswell, Mark. "The stereoselective Pictet-Spengler reaction and studies towards the total synthesis of ajmaline." Thesis, Keele University, 2013. http://eprints.keele.ac.uk/3816/.

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Due to their extensive and important medicinal properties, the indole alkaloids are an important class of natural products. A key step towards the total synthesis of indole alkaloids is the diastereoselective Pictet-Spengler reaction, which has enabled the total syntheses of a number of these natural products to be reported, one of which is the medicinally-important alkaloid ajmaline. Ajmaline is well studied and the previous attempts towards its synthetic preparation are described. During our investigations towards the asymmetric syntheses of ajmaline and other related indole alkaloids, it wa

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9

Herlé, Bart. "Stereoselective Cyclopropanations via Gold(I)-Catalyzed Retro-Buchner Reactions." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/454770.

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La formació de carbens bencílics d’or(I) a partir de cicloheptatriens substituïts en la posició 7, a través de la reacció de retro-Buchner, ha aparegut recentment com una alternativa segura i versàtil a la descomposició de diazocompostos. No obstant, la formació de dits carbens requereix altes temperatures, limitant la seva aplicació. El treball d’aquest tesi doctoral s’ha dedicat a superar aquesta desavantatge i millorar la versatilitat de la transformació. Els derivats de 1H-ciclopropa[l]fenantrè, que s’assemblen al tautòmer norcaradiè del cicloheptatriè, es descomponen per donar lloc a

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10

Peace, Simon. "The stereoselective nitro-Mannich reaction and its application towards the synthesis of vicinal diamines." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287661.

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11

Horsfall, L. R. "Stereoselective synthesis of pyrrolidinones via nitro-Mannich reaction : towards the synthesis of popolohuanone E." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324535/.

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Part 1: The first section of this thesis details the stereoselective synthesis of pyrrolidinones via the nitro-Mannich reaction. Expanding on previous work within the Anderson group, conjugate addition of a diorganozinc species to nitroacrylate 141 was carried out successfully. Subsequent in situ nitro-Mannich reaction was then followed by spontaneous lactamisation to afford the desired five-membered ring pyrrolidinone structure. The reaction was performed in one pot, generating three contiguous stereocentres in a highly diastereoselective manner. The scope of the reaction was investigated by

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12

Gilley, Cynthia Brooke. "New convertible isocyanides for the Ugi Reaction application to the stereoselective synthesis of omuralide /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3328498.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed November 5, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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13

Dogan, Sengul Dilem. "Regioselectivity In The Ene Reaction Of Singlet Oxygen With Cyclic Alkenes And Application Of Ene Reaction To Stereoselective Synthesis Of Carbaheptopyranose Derivatives." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612648/index.pdf.

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In the first part of this thesis is related to the regioselectivity in ene reaction of singlet oxygen with cyclic alkenes. The photooxygenation of 1-methyl-, 2,3-dimethyl-, 1,4-dimethylcyclohexa-1,4-dienes, 1,2,3,4,5,8-hexahydronaphthalene (16) and 2,3,4,7-tetrahydro-1H-indene (17) which are readily available through Birch reduction, yielded the ene products. The formed endocyclic dienes were trapped by the addition of singlet oxygen to give corresponding bicyclic endoperoxy-hydroperoxides. In the case of 1-methylcyclohexa-1,4-diene (13) and 1,4-dimethyl-cyclohexa-1,4-diene (15), cis-effect de

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14

Karak, Milandip. "A stereoselective vinylogous aldol reaction of tetronamides and the synthesis of rubrolides and beta- substituted butenolides." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/13425.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2017-11-21T15:24:32Z No. of bitstreams: 1 texto completo.pdf: 20136211 bytes, checksum: 27955f4b1fd7b5bdf978d63e7c835f6b (MD5)<br>Made available in DSpace on 2017-11-21T15:24:32Z (GMT). No. of bitstreams: 1 texto completo.pdf: 20136211 bytes, checksum: 27955f4b1fd7b5bdf978d63e7c835f6b (MD5) Previous issue date: 2017-01-27<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Os butenolídeos, que apresentam em sua estrutura o núcleo lactona α, -insaturada, são encontrados em produtos naturais e não naturais com div

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15

Crossman, Julia Stephanie, and julia crossman@flinders edu au. "Biomimetic Approaches to the Synthesis of Polyketide Derived Marine Natural Products; (-)-Maurenone and the Spiculoic Acids." Flinders University. SoCPES, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20080212.134949.

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This thesis describes the total synthesis of the polyketide derived marine natural product (-)-maurenone (14) and synthetic studies of a model system for the marine polyketides, the spiculoic acids (20, 22-24). A biomimetic approach involving cyclisation of linear polyketide precursors to install the complex chemical frameworks was employed. Maurenone is a polypropionate derived metabolite isolated from pulmonate molluscs collected off the coast of Costa Rica. While structural assignment following isolation revealed a relatively uncommon tetra-substituted dihydropyrone moiety the only ster

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16

Guerrera, Cessandra. "Stereoselective Synthesis of alpha,alpha-Disubstituted Amino Acids Utilizing Porcine Liver Esterase and the Petasis Borono-Mannich Reaction." Thesis, Southern Connecticut State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10283110.

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<p> Arginase is a manganese-containing enzyme that catalyzes the hydrolysis of L-arginine to yield L-ornithine and urea. It has been suggested that inhibition of arginase could be of therapeutic utility, and an arginase inhibitor is currently in phase I clinical trials for a variety of cancer subtypes. To date, the most promising inhibitors reported in the literature are α,α-disubstituted arginine analogs with a boronic acid warhead in place of the substrate guanidine group. However, the stereoselective approaches reported to date for this class of compounds have significant limita

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17

Laws, Stephen William. "Total Synthesis of (+)-Malbrancheamide B Utilizing a Stereoselective Domino Reaction Sequence to Establish the Bicyclo[2.2]diazaoctane Core." W&M ScholarWorks, 2013. https://scholarworks.wm.edu/etd/1539626719.

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18

Danielsson, Jakob. "Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters". Licentiate thesis, KTH, Organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-95467.

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This thesis deals with the development of new reaction methodology as well as stereochemical investigations. The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. In particular, the unexpected 1,2-syn selectivity obtained in the addition of sterically hindered nucleophiles to α-chloroaldehydes is examined, and an explanation for the observed stereochemical trends is proposed. The second part describes the development of a novel entry to α-amino-β- hydro

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19

Penwell, Andrea J. "Sequential cycloadditions for the synthesis of taxoid mimics and stereoselective synthesis of tamoxifen analogues via a new carbomagnesiation-palladium coupling reaction." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26342.

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Studies towards the synthesis of TaxolRTM mimics 19 and 20 are described. The strategy involved two sequential Diels-Alder reactions to form the ABC ring system. The synthesis of aromatic analogue 19 was abandoned due to the lack of regioselectivity and low yields in the Diels-Alder reaction. More progress was made in the synthesis of norbornane analogue 20. In situ oxidation of methyl-2,5-dihydroxybenzoate, followed by cycloadditions with 2-triisopropylsilyl-1,3-butadiene and cyclopentadiene, respectively, gave the tetracyclic skeleton 56 in good yield. Further manipulations afforded compoun

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20

Datta, Gopal K. "Heck Reactions with Aryl Chlorides : Studies of Regio- and Stereoselectivity." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9202.

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21

ROUX, BRUNO. "Synthese regio et stereoselective d'acides alpha-amines par la reaction enique application a la preparation d'analogues de conformation restreinte de l'acide diaminopimelique." Paris 6, 1990. http://www.theses.fr/1990PA066676.

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Nous avons entrepris la preparation d'analogues de conformation restreinte de l'acide gamma-methylene diaminopimelique, afin de determiner la conformation bioactive de cette molecule qui possede une activite antibiotique notable envers les bacteries gram negatif mais dont le mecanisme d'action n'est pas encore elucide. Pour synthetiser les acides alpha-amines beta, gamma-et/ou gamma, delta-insatures vises, nous avons choisi d'utiliser la reaction enique, du fait de ses possibilites de regio et de diastereoselectivite. L'utilisation d'olefines cycliques fonctionnalisees, domaine encore peu etud

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22

Duchesne, Jean-Pierre. "Nouvelle voie d'acces aux aldehydes terpeniques : synthese stereoselective des isomeres 11-trans du retinal a l'aide de sulfones." Paris 6, 1987. http://www.theses.fr/1987PA066347.

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23

Burke, Elizabeth Diane. "Stereoselective carbon-carbon bond forming reactions : improving the stereoselectivity of a catalytic homoaldol reaction and the development of a general method to access the [alpha]-quaternary carbon [beta]-hydroxy carbonyl motif." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85054.

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The following thesis describes two stereoselective carbon-carbon bond forming processes---the aldol reaction and its one-carbon homologue, the homoaldol reaction. The first chapter describes our efforts to increase the stereoselectivity of a catalytic homoaldol reaction. This methodology features a second generation Binol titanium (IV) fluoride catalyst capable of opening a silyloxycyclopropane ring to form discrete homoenolates. These homoenolates react with a variety of aldehydes to form 1,4-hydroxy carbonyl compounds. The catalyst was prepared by a literature method and has improved

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24

Gallanti, M. "STEREOSELECTIVE SYNTHESIS OF A-AMINO ACIDS B-SUBSTITUTED WITH A 4,5-DIHYDROISOXAZOLE NUCLEUS AND OF TERTIARY AND QUATERNARY ALLYLSILANES." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168366.

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In the section A of the thesis is presented a stereoselective synthesis of b-hydroxy-a -amino acids b-substituted with a 4,5 dihydroisoxazole nucleus through an aldol type reaction between Schollkopf reagent and isoxazolynil aldehydes and ketones. In the section B is presented the preparation of allyl- or crotylsilane in high dr and er via the lithiation-borylation reaction of alkylcarbamates with silaboronates.The synthesis of quaternary allylsilane through a related strategy is also presented.

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25

MRIDHA, MD MONIRUZZAMAN. "HIGHLY STEREOSELECTIVE ALDOL REACTION BY THE COMBINATION OF AMINOACID AND HYDROGEN BOND DONATING CATALYSTS IN WATER AND APPLICATION FOR CONCISE SYNTHESIS OF D-Lyxo-PHYTOSPHINGOSINE." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328534.

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26

Tiong, Erica. "Stereoselective formation of all carbon quaternary centers: synthesis of alpha,alpha-disubstituted beta-amino carbonyl compounds via the Mannich reaction and total synthesis of (-)-puraquinonic acid." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104585.

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A bicyclic thioglycolate lactam chiral auxiliary was previously developed in our group for the asymmetric formation of quaternary carbon stereocenters via enolate alkylation. This method is notable for the stereocontrolled generation of alpha, alpha-disubstituted amide enolates, without reliance on the steric differences of the alpha-substituents. Coupled with excellent facial discrimination in electrophilic approach, this led to a general and practical method for enantioselective preparation of quaternary carbon centers via alkylation reactions. This thesis describes the extension of this met

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27

Trejos, Alejandro. "Palladium-Catalysed Couplings in Organic Synthesis : Exploring Catalyst-Presenting Strategies and Medicinal Chemistry Applications." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173068.

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Palladium-catalysed coupling reactions have been embraced by synthetic chemists as one of the preferred means for smooth formation of new carbon-carbon bonds: a truly ubiquitous methodology of synthesizing complex molecules. This thesis describes the study of a series of palladium(0)-catalysed C2-arylations of a 1-cyclopentenyl ether, equipped with a chiral (S)-N-methyl-pyrrolidine auxiliary. The investigated olefin was demonstrated to undergo Si-face insertion, providing (R)-configuration of the arylated C2-carbon. In addition, the mild and novel palladium(II)-catalysed dominoHeck/Suzuki β,α-

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28

Alabdullah, Basil. "Stereoselective organoborate rearrangement reactions." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/75961/.

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This thesis describes the use of organoborate rearrangement reactions to generate quaternary carbon centres, with the ultimate goal of exploring new procedures for the asymmetric synthesis of chiral quaternary carbon centres. Chapter One: this chapter contains a historical review of the use of organoboranes in organic synthesis, focusing mainly on the use of boronic esters in asymmetric organic synthesis. Chapter Two: this chapter focuses on attempts at developing a catalytic method for the generation of quaternary stereocentres using migration reactions of boronic esters with n-butyllithium i

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29

Prasad, K. R. "Stereoselective carbonyl addition reactions." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1996. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3010.

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30

NOGUE, DENISE. "Synthese regio et stereoselective d'heterocycles azotes via la reaction d'imino diels alder. Analyse conformationnelle de decahydroquinolein-4-ones et de piperidin-4-ones par correlation rmn #1h, m. M. Et rx." Paris 11, 1993. http://www.theses.fr/1993PA112254.

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Le travail rapporte dans ce memoire concerne d'une part la synthese d'heterocycles azotes tels que les n-aryl-2-aryl decahydroquinolein-4-ones et les n-aryl-2-aryl piperidin-4-ones et, d'autre part, leur analyse conformationnelle. L'etude de la reaction d'imino diels alder du 1-(1-trimethylsilyloxyethenyl)-cyclohexene et d'imines catalysee par des acides de lewis a permis d'obtenir selectivement ou tres majoritairement les enoxysilanes exo ou endo selon la nature des groupes aryles ar et ar lies respectivement au carbone et a l'azote de l'imine. Ainsi, l'utilisation du t-butyldimethylsilyle tr

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31

Massolo, E. "NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330262.

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The objective of this PhD study was to apply organocatalytic synthetic methods for the regio- and stereoselective synthesis of highly functionalized compounds. We exploited different organocatalytic activation modes to peculiar substrates we identified as suitable building blocks for versatile products in enantiomerically enriched form. In particular the developed projects relied on stereoselective amino- and hydrogen bonding organocatalysis, employing beta-nitroacrylates, beta-trifluoromethylated nitroalkenes and 2,2,2-trifluoroethyl 2-[(1,3-dithian)-2-yl]-ethanthioate in combination with var

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Marín, Ferré Irene. "Stereoselective reactions in carbohydrate synthesis." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/76720.

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La Tesis que se presenta trata sobre el desarrollo de nuevos métodos selectivos de síntesis de carbohidratos. En la primera parte de la tesis se estudió la epoxidación de glicales utilizando catalizadores de Mo y ácido meta-cloroperbenzoico (MCPBA), en relación con la obtención de mano-oligosacáridos. En todos los casos estudiados, el epóxido formado se abría in situ para dar lugar al correspondiente diol o glicósido. Se observó un efecto director por parte de los hidroxilos libres, lo que permitía obtener derivados de manosa a partir de glucosa. En el caso del Mo, los resultados figuran entr

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Yan, Ni. "Stereoselective carbometallation reactions of cyclopropenes." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 207 p, 2008. http://proquest.umi.com/pqdweb?did=1456289621&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Maberly, T. R. "Stereoselective reactions of iron complexes." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375266.

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Peverall, S. F. "Investigation of novel stereoselective reactions." Thesis, Swansea University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638517.

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Chapter 1 reviews the field of asymmetric synthesis with special emphasis on stereoselective enolate formation and reaction. The physical and chemical characteristics of [2.2]paracyclophane derivatives and other planar chiral compounds are examined and their role in asymmetric synthesis mentioned. Chapter 2 investigates the role of [2.2]paracyclophanes as planar chiral auxiliaries. The stereoselective production and α-substitution of [2.2]paracyclophane ester enolates is investigated. Chapter 3 introduces the field of boron stabilised carbanion chemistry and investigates the diastereoselective

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36

RIGUET, ERIC. "Reaction de couplage aryl-aryle, entre un organometallique et un bromure ou un chlorure aromatique, catalysee par un complexe du palladium ou du nickel. Cyclisation stereoselective utilisant un nouveau systeme catalytique mn/cu." Paris 6, 1997. http://www.theses.fr/1997PA066715.

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La reaction de couplage aryl-aryle, nouvellement developpee, permet l'acces a un nombre important de diphenyles dissymetriques fonctionnalises diversement substitues a partir de bromures d'aryles. Les conditions reactionnelles sont douces (+20 a +65\c), les rendements sont bons (>90%) et les temps de reaction sont courts (environ 2 heures). - l'utilisation d'un compose organomanganeux, en presence d'une quantite catalytique d'un complexe du palladium puis d'un co-solvant tel que le dme, a permis le bon deroulement d'une telle reaction. - de la meme facon, avec les iodures et triflates d'aryle

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RAEPPEL, STEPHANE. "Synthese stereoselective de dienediynes tricycliques analogues structuraux du chromophore de la neocarzinostatine et approche synthetique du coeur de ce puissant anticancereux naturel. Nouvelle voie de synthese d'enediynes macrocycliques par la reaction s#nar." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13167.

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Au cours de ce travail de these nous avons etudie et realise : - la synthese stereoselective et convergente de dienediynes tricycliques analogues structuraux du chromophore de la neocarzinostatine, a partir de diynes aromatiques et du (z)-bis(triflate d'enol). - une approche synthetique du cur de ce puissant anticancereux naturel. Pendant ce projet nous avons elabore une synthese alternative des deux enantiomeres de la trans-3,4-bis(benzyloxy)cyclopentanone en sept etapes a partir du diethyl tartrate comme substrat chiral non racemique et ouvert une nouvelle voie d'acces a des cycles a cinq ch

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38

Bender, Christoph. "Stereoselektive Synthese neuartiger 1,2-Dihydroisochinoline als Vorstufen für die Alkaloidsynthese." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15728.

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Ausgangspunkte der vorliegenden Arbeit waren stereoselektive Synthesen von Reissert-Verbindungen über chirale N-Acylisochinoliniumsalze. Es galt die Konfiguration der erhaltenen Produkte zu beweisen und deren Synthesepotential zu erforschen. Ein Ziel dieser Arbeit war es, weiterführende Reaktionen für die Synthese von alkaloidanalogen Substanzen zu entwickeln. Es gelang, die Reissert-Reaktion mit Chlorameisensäurementhylester erfolgreich auf andere Heterocyclen als Isochinolin auszudehnen. Die Annahme eine stereoselektiven Verlaufes mußte korrigiert werden. Das Reissert-Produkt konnte mit eine

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39

Blumenthal, Haiko. "Struktur und Reaktivität ausgewählter chiraler N-Acylaminohydroperoxide und -peroxide." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15868.

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Ausgangspunkte der vorliegenden Arbeit waren stereoselektive Synthesen von Reissert-analogen N-Acylaminohydroperoxiden über chirale N-Acylisochinoliniumsalze. Edukte waren Isochinolin(derivaten), Menthylchloroformiat und Wasserstoffperoxid. Es galt die Konfiguration der erhaltenen Produkte zu beweisen und deren Sauerstoffübertragungspotential zu erforschen. Ein zweites Ziel dieser Arbeit war es, von bekannten Diketopiperazinhydroperoxiden ebenfalls das Sauerstoffübertragungspotential zu überprüfen, weil sie die gleiche N-Acylaminohydroperoxidstruktur aufweisen aber bisher wenig untersucht wurd

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40

PUGNAUD, SYLVIE. "Etude theorique de reactions stereoselectives : - reaction de diels-alder a demande inverse d'electrons - hydrogenation de cycloalcenes." Paris 6, 2000. http://www.theses.fr/2000PA066389.

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La these comporte deux parties : partie a : la stereochimie de la cycloaddition du nitroethene, pris comme modele du 6-nitrobenzofuroxane, avec l'ethenol et la vinylamine a ete etudiee au niveau dft. L'analyse des om montre que cette reaction a demande inverse d'electrons est sous controle des orbitales frontalieres. Un chemin reactionnel en une etape avec un etat de transition dissymetrique est plus probable qu'un mecanisme en deux etapes dans lequel l'intermediaire a un caractere essentiellement biradicalaire. L'etude de reactions d'une serie de 6-nitrobenzofuroxanes substitues en position 4

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41

Easton, R. J. C. "Stereoselective synthesis via iron acyl complexes." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379991.

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Smith, Elin Hopcyn. "Stereoselective Hex-5-enyl radical cyclisations." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259644.

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43

Xie, Jianing. "Advancing Pd-catalyzed Stereoselective Allylic Substitution Reactions." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670221.

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Aquesta tesi doctoral se centra principalment en el desenvolupament de nous mètodes catalítics (dòmino) basats en la substitució al·lílica catalitzada per Pd per a la síntesi estereoselectiva de petites molècules funcionals i heterocicles utilitzant un disseny detallat de lligants i substrats. Aquesta tesi està organitzada en cinc capítols: el primer capítol és una introducció general sobre els aspectes bàsics de la química al·lílica. El segon capítol il·lustra el primer mètode general per a la preparació d'èters arílics al·lílics terciaris enantioenriquits mitjançant una eterificación regio-

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44

Baar, Cliff Robert. "Stereoselective reactions of organoplatinum and organopalladium complexes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/NQ58394.pdf.

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45

Joensuu, Pekka Matias. "Development of catalytic stereoselective reductive aldol reactions." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2576.

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The chemistry of enolates can be considered one of the cornerstone areas in organic chemistry. Regioselective generation of an enolate in the presence of several enolisable sites can often prove to be a difficult task. Discoveries in recent years have led to new areas of enolate formation in the presence of other carbonyl groups. These include reductive aldol chemistry where direct reductive aldol coupling of an alpha,beta - unsaturated carbonyl group in presence of a carbonyl electrophile enables often perfectly regioselective reactions to occur. This tandem conjugate reductionelectrophilic t

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46

Goodfellow, Craig L. "Stereoselective reactions of arene chromium tricarbonyl complexes." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:e2833156-aec2-42e5-b835-e9ddca4fa27c.

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This thesis describes the application of (arene)Cr(CO)3 methodology to the Stereoselective and enantioselective synthesis of substituted arenes. Chapter one reviews the main methods of preparation and decomplexation of (arene)Cr(CO)<sub>3</sub> complexes and the electronic and steric influences of the Cr(CO)<sub>3</sub> unit on the arene. Chapter two demonstrates that the benzylic oxygen directing effect in complexation reactions operates via a direct oxygen bond to the incoming metal unit. Attachment of bulky ft-acceptor groups, such as t-butyldimethylsilyl, to the benzylic oxygen overrides t

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47

Kaiser, Delene Anne. "Stereoselective reactions of 16-Methylene 19-Norsteroids." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/22136.

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The influence of the 17-substituent upon epoxidation of 3-methoxy-16-methylene-estra- 1,3,5(10)-trien-17-one and the derived 17β-hydroxy and 17β-acetoxy compounds was investigated. Alkaline hydrogen peroxide epoxidation of 3-methoxy-16-methyleneestra- 1,3,5(10)-trien-17-one occurred in good yields, but poor stereoselectivity was obtained due to mechanistic considerations. Poor stereoselectivity was also obtained for the peracid epoxidation of 3-methoxy-16-methylene-estra-1,3,5(10)-trien-17β-ol, due to the pseudo-equatorial position of the 17β-hydroxyl group. However, excellent stereoselectivit

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48

Guiteras, Capdevila Montserrat <1980&gt. "Development of Organocatalytic stereoselective SN1 type reactions." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4370/1/Guitera_Capdevila_Montse_tesi.pdf.

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The proposal in my thesis has been the study of Stereoselective α-alkylation through SN1 type reaction. SN1 type reaction involves a stabilized and reactive carbocation intermediate By taking advantages of stability of particular carbocations, the use of carbocations in selective reactions has been important. In this work has been necessary to know the stability and reactivity of carbocations. And the work of Mayr group has helped to rationalize the behaviour and reactivity between the carbocations and nucleophiles by the use of Mayr’s scale of reactivity. The use of alcohols to performed th

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49

Guiteras, Capdevila Montserrat <1980&gt. "Development of Organocatalytic stereoselective SN1 type reactions." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4370/.

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The proposal in my thesis has been the study of Stereoselective α-alkylation through SN1 type reaction. SN1 type reaction involves a stabilized and reactive carbocation intermediate By taking advantages of stability of particular carbocations, the use of carbocations in selective reactions has been important. In this work has been necessary to know the stability and reactivity of carbocations. And the work of Mayr group has helped to rationalize the behaviour and reactivity between the carbocations and nucleophiles by the use of Mayr’s scale of reactivity. The use of alcohols to performed th

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50

Porta, R. "STEREOSELECTIVE CATALYTIC REACTIONS UNDER CONTINUOUS FLOW CONDITIONS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/479336.

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This PhD Thesis deals with the application of different catalytic methodologies under continuous flow conditions. In particular, the combination of flow chemistry with different enabling technologies is explored. In Chapter 1 the combination of continuous flow processes with the use of different solid supported chiral organocatalysts is described. The fabrication of chiral, packed-bed and monolithic, organocatalytic reactors and their use in stereoselective transformations are reported. The possibility to recycle the immobilized chiral catalysts is also discussed. - In section 1.2 the use of

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