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Dissertations / Theses on the topic 'Steric effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Liu, Sung Ying. "Steric effects in Lanthanide pyrazolylborate chemistry." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561271.

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2

Laitinen, R. (Riitta). "New heterodonor phosphine and bipyridine ligands." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514252292.

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Abstract Twenty-seven phosphine and six bipyridine ligands were synthesised and characterized. Additionally, a new route to the family of phosphine ligands via o-thioanisyldichlorophosphine was found. The phosphine ligands contain thiomethylphenyl, methoxyphenyl, dimethylaminophenyl, pyridyl, naphthyl and anthracenyl groups, and the bipyridine ligands thiomorpholine and piperidine groups. Metal complexes of 3-pyridyldiphenylphosphine, 6,6'-bis(methylthiomorpholine)-2,2'-bipyridine and 4,4'-dimethyl-6,6'-bis(methylthiomorpholine)-2,2'-bipyridine were prepared. Ligands and complexes were charac

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3

McLachlan, Lorna J. "Steric and electronic effects on the structures of substituted silicon compounds." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/15345.

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This thesis is concerned with the application of the SARACEN method to a range of molecules with interesting structural properties and applications in industry. The gas-phase structures of a series of compounds have been obtained, combining gas-phase electron diffraction and <i>ab initio </i>molecular orbital theory. For each compound a series of the potential energy surface was carried out to investigate the number of conformational minima and to locate the global energy minimum. The gas-phase structures of <i>trans-</i>1,2-dichloro-1,2-disilylethene (1), 1,1-bromosilylethene (2) and 1,1,1,4,

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4

Smith, Adam C. R. "The Effects of Carrier Ligands on Cisplatin Binding to Cysteine and Methionine." TopSCHOLAR®, 2017. http://digitalcommons.wku.edu/theses/1969.

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We have reacted several derivatives of the anticancer drug cisplatin with N-acetyl-Lcysteine (N-AcCys) and N-acetyl-L-methionine (N-AcMet), which are two of the primary amino acid targets of platinum. NMR spectroscopy was used to monitor the reactions and determine the effect the different ligands would have on the platinum reactivity. Several of the platinum compounds were tested at pH of 4 and 7, and with platinum:amino acid ratios of 1:1, 2:1 and 1:2. Competition reactions between cysteine and methionine were done to confirm which would react with the platinum compound first. [Pt(dien)(NO3)

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5

Bachir, Alexia. "Characterization of quantum dot blinking and steric effects on fluorescence-based biophysical techniques." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19293.

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Semiconductor nanoparticles, or quantum dots (QDs) are being increasingly applied as luminescent labels in optical studies for biophysical and cell biological applications due to their unique spectroscopic properties as compared to traditional organic fluorescent probes. However, the intermittency in the fluorescence emission of QDs, commonly referred to as 'blinking', is suggested to affect transport studies using fluctuation correlation techniques. The QD size has also been suggested to be sterically limiting for some st

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6

Yang, Shaoguang. "Design and Investigation of Polyurethane End-Capped Polyesters with Controlled Hydrolytic Stability." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1407971721.

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7

Ramirez-Huerta, Mayela Cristina. "Steric and Anchimeric Effects on the Hydrolysis of Oligoesters and their Influence on End-Use Polyurethane Coatings." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1258662846.

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8

Desai, Salil Dileep. "Ortho substitution effects on the acidic and alkaline hydrolyses of formanilides." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/353.

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The objectives of this project were to determine the reaction schemes of formanilide and substituted formanilides in acidic and alkaline solutions, to quantiate the kinetics of hydrolysis, to propose reaction mechanisms, and to assess the role of ortho words substitution in formanilide hydrolysis kinetics. A set of thirty substituted formanilides were synthesized and characterized. Hydrolysis of the formanilides was carried out under first order conditions in hydrochloric acid (0.01-8 M, 40°C) and in hydroxide solutions (0.01-3 M, 25°C and 40°C). Hydrolysis kinetics were evaluated in terms of

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9

Kahan, Rachel Jennifer. "Investigating the steric and electronic effects of low-valent uranium complexes on the activation of small molecules." Thesis, University of Sussex, 2015. http://sro.sussex.ac.uk/id/eprint/54170/.

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In the last decade substantial progress has been made in our understanding of uranium organometallic chemistry, specifically regarding the activation of small molecules by uranium(III) complexes. Research by Cloke and colleagues has employed dianionic eight- and monoanionic five-membered aromatic ligands around a uranium(III) centre to make mixed-sandwich systems, which have demonstrated novel reactivity with carbon monoxide and carbon dioxide. This thesis continues this work and furthers our understanding of the properties and reactivity of these complexes. The first part of this thesis descr

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10

Djomgoue, Paul. "N3, N4/(N3S, N3O) and N6 Phenanthroline Bases and their Spin Crossover Iron(II) Complexes." Doctoral thesis, Universitätsbibliothek Chemnitz, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-207498.

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The present dissertation focuses on the synthesis of iron(II) complexes and the study of their SCO behavior. The equilibrium between the HS and the LS states gives to the SCO systems large potential applications for molecular electronics. However, today there is not a single molecular device from SCO compounds in the market. This is due to the fact that the SCO systems discovered up to now were unable (e.g. TLIESST « 300 K) for these applications. The aim of this thesis is to synthesize new SCO compounds with sustainable properties for applications. In the beginning of the thesis, [Fe(rac-22a)

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11

Tanna, Jigisha. "ANTI Preference of the Pyramidalized Radical Center to the Two Fluorines in Difluoro Cyclic Compounds." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc6047/.

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An extensive study of disubstituted cycloalkanes like CnH2n where n=3,4,5 and 6 using DFT((U)B3LYP/6-31G(d) and 6-311+G(2df,2p)) calculations is presented focusing on the effect of pyramidalization of the radical center. A potential energy surface (PES) analysis shows that the radical prefers to pyramidalize anti to the two cis fluorines in the disubstituted cycloalkanes. The degree of pyramidalization for 1,2-difluorocyclopropyl radical is 43.9o away from the cis fluorines whereas for 1,3-difluorocyclobutyl radical, 1,3-difluorocyclopentyl radical and 1,3-difluorocyclohexyl radical is 3.8o, 5

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12

Taguchi, Hiroomi. "Studies on PNP-Pincer Type Phosphaalkene Complexes Stabilized by a Fused-Ring Bulky Protection Group." Kyoto University, 2018. http://hdl.handle.net/2433/232481.

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13

Companioni, Dania. "Targeting of ribonucleotide reductase with 2'-Disulfide analogs of adenosine. Electronic versus steric effects in radical deoxygenation of fluorine-containing nucleosides." FIU Digital Commons, 2002. http://digitalcommons.fiu.edu/etd/2417.

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Inhibition of the enzyme ribonucleotide reductase is an appealing concept for the rational drug design against rapid proliferation of systems such as viruses and cancer cells. Synthesis of 2'-thionucleoside analogs as possible inhibitors of the enzyme was targeted in this research. For protecting the reactive thiol group, mixed disulfides were prepared as precursors of the sulfur-containing nucleosides. The thionucleoside obtained are currently under biological studies. Fluorinated compounds are widely used in biochemistry, medicinal chemistry, and pharmacology. Synthesis of 2'-deoxy-2'-fluoro

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14

Eagan, Robert Lee. "Investigation of the steric and/or electronic effects associated with the (1,5)-sigmatropic rearrangement of 1-substituted-2,3,4,5-tetraphenyl- 2,4-cyclopentadien-1-ols." Diss., Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/74730.

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A series of eight l-substituted-2,3,4,5-tetraphenyl-2,4-cyclopentadien-l-ols were efficiently synthesized by the addition of the appropriate organometallic reagent to tetracyclone. It was determined that the steric and electronic nature of the migrating groups played a predictable role in the [l,5]-sigmatropic rearrangement of these compounds. Electron donating groups increased the rate of migration whereas electron withdrawing substituents were responsible for slowing the migration. Likewise, smaller groups accelerated the rate while bulky groups deterred the migration. Consequently, the expe

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15

Budiarto, Thomas [Verfasser], Jens-Uwe [Akademischer Betreuer] Repke, Jens-Uwe [Gutachter] Repke, and Peter [Gutachter] Strasser. "Modeling process dynamics in membrane-electrolyte-assemblies of chloralkali electrolyzers considering steric and hydration effects / Thomas Budiarto ; Gutachter: Jens-Uwe Repke, Peter Strasser ; Betreuer: Jens-Uwe Repke." Berlin : Technische Universität Berlin, 2021. http://d-nb.info/1230468374/34.

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16

Castronovo, Matteo. "Crowding effects on biochemical reactions of surface-bound DNA." Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2616.

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2006/2007<br>Next-generation DNA detection arrays are expected to achieve unprecedented sensitivity, reducing the minimum amount of genetic material that can be directly (PCR-free and label-free) and quantitatively detected, up to the single cell limit. To realize these goals, we propose a new method for the miniaturization of DNA arrays to the nano-scale, which has the unique capability of controlling the packing quality of the deposited bio- molecules. We used NanoGrafting, a nano-lithography technique based on atomic force microscopy (AFM), to fabricate well ordered thiolated single stra

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17

Chen, Chung-pin. "Part I: Steric and inductive effects on the hydrolysis of quinone bisketals ; Part II: A convenient route to ortho-alkylated phenols and quinone monoketals. Part III: A general approach to quinone ketals. Part IV: Preparation and chemistry of quinone... /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487268021749158.

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18

Heider, Silvio. "Synthese neuer tri- und hexadentater Stickstoffbasen für Eisen(II) Spin Crossover Komplexe." Doctoral thesis, Universitätsbibliothek Chemnitz, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-120783.

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Die vorliegende Arbeit thematisiert Eisen(II)-Komplexe mit Spinübergangseigenschaften. Dafür wurden neue hexadentate Liganden auf Basis von N,N'-Bis(2,2'-bipyridin-6-ylmethyl)-2,2'-biphenylendiamin entwickelt. Die in Kapitel 3.1 vorgestellten Systeme variieren dabei in den jeweiligen Substituenten der 6,6‘-Positionen der Biphenyleinheit. Es wird der Einfluss dieser Gruppen auf die magnetischen Eigenschaften der resultierenden Komplexe gezeigt. Im darauffolgenden Kapitel 3.2 wird ein variiertes Ligandensystem vorgestellt, in welchem anstelle einfacher Substituenten Donorfunktionen eingeführt wu

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19

Tanji, Yutaka. "Steric Effect of Carboxylate Ligands on Pd-Catalyzed C-H Bond Arylation Reactions." Kyoto University, 2020. http://hdl.handle.net/2433/253293.

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20

Abbott, Joshua E. "Interactive Depth-Aware Effects for Stereo Image Editing." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3712.

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This thesis introduces methods for adding user-guided depth-aware effects to images captured with a consumer-grade stereo camera with minimal user interaction. In particular, we present methods for highlighted depth-of-field, haze, depth-of-field, and image relighting. Unlike many prior methods for adding such effects, we do not assume prior scene models or require extensive user guidance to create such models, nor do we assume multiple input images. We also do not require specialized camera rigs or other equipment such as light-field camera arrays, active lighting, etc. Instead, we use only a

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21

Teci, Matthieu. "Coordination chemistry of N-heterocyclic carbenes substituted by alkylfluorényl groups : weak interactions, steric effets, catalysis." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF010/document.

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Cette thèse porte sur l’étude de nouveaux carbènes N-hétérocycliques dont les atomes d'azote sont substitués par des groupes étendus alkylfluorényle (AF). Les caractéristiques principales de ces coordinats sont leur fort encombrement stérique, la modularité de ce dernier, et la proximité créée dans les complexes correspondants entre les groupes AF et le métal coordiné.La première partie de ce travail décrit la synthèse et la caractérisation d'un ensemble de sels d’azolium, précurseurs de cette nouvelle famille de NHCs. Ces composés ont d'abord été utilisés pour la préparation de complexes de p

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22

Seymour, Beverley Lesley. "The effect of steroid hormones on the size of myometrial cells : a morphometric study." Thesis, Cape Technikon, 1997. http://hdl.handle.net/20.500.11838/1503.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, Cape Town,1997<br>The aims of this study were to measure: 1. Myometrial cells of menopausal uteri to establish whether they atrophy after the menopause. 2. Myometrial cells at different phases of the menstrual cycle to investigate the influences of oestrogen and progesterone during the cycle. 3. Myometrial cells in the fundus and lower uterine segment to establish whether they differ in size. 4. Myometrial cells of pregnant uteri to investigate the effect of the hormonal status of pregnant women on the size of myometrial cells. 5

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23

Tra, John. "Effects of dietary linoleic and stearic acids on the PGE2 content of mammary tumors in strain a/s female mice." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115750.

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Prostaglandin E2 (PGE2), a byproduct of arachidonic acid metabolism, has been suspected to be involved in tumor promotion. It has been suggested that diet may modulate PGE2 level in organisms thus affecting the implantation and growth of the tumor tissue. PGE2 content was investigated in mice fed ad libitum four types of fatty acid diets: saturated fatty acid diets: a stearic acid and a palmitic acid, and polyunsaturated fatty acid diets: a low fat (safflower 1%) and a high fat diet (safflower 15%). Tumor cells were implanted subcutaneously in mice and harvested when tumors reached .05- 4g. Th

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Zhang, Bei. "STUDY OF THE EFFECT OF STERIC BULK OF SIDE CHAINS ON THE PROPERTIES OF CONJUGATED POLYMERS." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/95.

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Donor-acceptor conjugated polymers opened a new era for conjugated polymer research due to the abundant selection and combination of diﬀerent conjugated units. This class of polymers function as semiconductor materials with potential application in plastic consumer electronics. The frontier molecular orbital energies of the polymers are generally determined by the selection of donor and acceptor units in the backbone structure, and their substituents. The side chains attached to the backbone not only affect the solubility of the materials, but also their self-assembly and morphological charact

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Petiraksakul, Pinsupha. "Effect of stearate/stearic acid coating on filled high density polyethylene properties." Thesis, Loughborough University, 2000. https://dspace.lboro.ac.uk/2134/11166.

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High density polyethylene (HDPE) is a widely used plastic but it is also a combustible material. One way of reducing flammability is to add fillers, such as magnesium hydroxide (Mg(OH)2). However, this has a deleterious effect on the mechanical properties of composites. It has been found that one possible method of restoring mechanical properties is to modifY the filler particles with coating agents, such as stearic acid. In the present work, this idea was taken a stage further with the use of various metal stearates (e.g. magnesium stearate, calcium stearate, and zinc stearate) for modifying

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Mukerji, Mark Sanjiv. "The effects of progesterone and related compounds on the contractility of rat vascular smooth muscle." Thesis, Lancaster University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302393.

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王衛慶 and Wei-qing Wang. "Prevention therapy on bone loss in asthmatic patients on high dose inhaled steroids." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214691.

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28

Seefried, Kim. "Visualizing effects : In stereoscopic images." Thesis, Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-63881.

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This thesis explores and includes research on different impressions given in stereo rendering when creating a fire in three different manners.As technology progresses, stereoscopic rendering becomes increasingly more popular. Both movies and games are shown through VR to give users a more satisfying and lifelike interaction with a virtual environment.Three different versions of a fire were created in a game engine and then viewed with HTC Vive. Comparing mono and stereo rendering gave insights on how the different method looks when using stereoscopic rendering, and what impression the differen

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SANTOS, FABIO ALEX PEREIRA DOS. "STUDY OF THE EFFECTS OF STERILE NEUTRINOS IN BETA DECAY EXPERIMENTS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2008. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=12397@1.

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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Nesta dissertação, estudamos do ponto de vista fenomenológico, os efeitos de neutrinos estéreis para os observáveis de massas de neutrinos baseado nos dados do experimento LSND e nos resultados divulgados recentemente pela colaboração MiniBooNE. Consideramos observáveis de massa as seguintes quantidades: o parâmetro de massa cinemática cuja medida é realizada em experimentos com o decaimento beta do tritium tendo seu valor atual fornecido pelos experimentos Mainz e Troitsk; a massa efetiva de Majorana, que é uma quantida

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Recke, Anna Lena. "Evaluierung der Aufnahme und des biologischen Effekts von steric block-Oligonukleotiden zur Spleißkorrektur nach peptidvermitteltem Transport in Säugerzellen." Lübeck Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1000297705/34.

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31

Woodward, Terry L. "Effects of ovarian steroids on bovine mammary epithelial cells : in vitro and in viro evidence of indirect stimulation of proliferation /." Thesis, Virginia Tech, 1991. http://hdl.handle.net/10919/41629.

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Three studies were conducted to determine the effects of ovarian steroids on bovine mammary epithelial cell proliferation. In a first study, estrogen (E), progesterone (P), or E+P were administered to prepubertal beef heifers and biopsied mammary parenchyma taken before and following treatment were compared for growth by evaluation of histoautoradiographic incorporation of thymidine. Estrogen increased epithelial cell growth by 24 h, and fibroblasts to a lesser magnitude by 48-96 h. Estrogen and P was less effective and P was ineffective in increasing proliferation in all cell types studied. P

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Rogers, Wendy J. "Effects of dietary stearic and linoleic acid on mammary carcinogenesis and longevity of aging strain A/ST mice." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115733.

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This investigation studies the effects of diets containing varying amounts of linoleic acid (a polyunsaturated fatty acid) and stearic acid (a saturated fatty acid) on tumorigenesis, weight and longevity in strain A/ST mice. Linoleic acid [ 18 carbons and 2 double bonds (18:2)] was chosen to represent a fatty acid known to enhance tumorigenesis and obesity in certain strains of mice. Stearic acid [ 18 carbons and no double bonds (18:0)] represents a saturated fatty acid known to increase the latency period for mammary tumor development and to decrease the rate of tumor growth. This study was c

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Recke, Anna Lena [Verfasser]. "Evaluierung der Aufnahme und des biologischen Effekts von steric block-Oligonukleotiden zur Spleißkorrektur nach peptidvermitteltem Transport in Säugerzellen / Anna Lena Recke." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1000297705/34.

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Pomari, Elena. "Local synthesis and effect of sex steroids in human skin and the hair follicle and hormonal effects on the wound healing response." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421994.

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Humans, as others mammals, are able to synthesize steroid hormones from endocrine organs, such as gonads, adrenal gland and placenta. The expression and activity of steroidogenic enzymes in peripheral tissues provide the intracrine production of active androgens and estrogens by transformation of adrenal precursor dehydroepiandrosterone (DHEA). Only human and primates are unique in having large amounts of the inactive adrenal DHEA and especially DHEA-sulfate (DHEA-S). However, adrenal secretion decreases from the age of 30 years in both sexes, thus potentially providing an explanation for part

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O'Connor, Christine A. "The effects of oestrogen and progesterone on outcome following experimental traumatic brain injury in rats /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09pho186.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 2004?<br>Includes list of articles published or accepted for publication during the period of PhD candidature. "July, 2004" Includes bibliographical references (leaves 255-293).

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Hoang, Ngoc-Anh S. "Tissue specific effects of [beta]FTZ-F1 loss-of-function on the early gene E93 transcription during Drosophila melanogaster metamorphosis /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/140.pdf.

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Carlson, Linda E. "Steroid hormones and memory in healthy elderly men, in women estrogen-users and non-users and in patients with Alzheimer's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0021/NQ44379.pdf.

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Simon, Kathryn D. "Effect of cellular zinc concentration on glucocorticoid induced gene expression." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-06062008-155344/.

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Dohse, K. C. "Effects of field of view and stereo graphics on memory in immersive command and control." [Ames, Iowa : Iowa State University], 2007.

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Acero, Ortega Mario Andrés. "Neutrino oscillations in gallium and reactor experiments and cosmological effects of a light sterile neutrino." Chambéry, 2009. http://www.theses.fr/2009CHAMS002.

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Nous étudions l'anomalie observée dans les expériences de source radioactive Gallium, faites pour tester les détecteurs Gallium solar neutrino GALLEX et SAGE, mesure d'un nombre total des événements était inférieur a celui attendu. Nous avons interprété cette anomalie comme une indication possible de la disparition des neutrinos électroniques et, dans le cadre effectif de mélange de neutrinos à deux saveurs, nous avons obtenu sin2 2Ө> 0. 03 et « delta »m² > 0. 1 eV2. La compatibilité de ce résultat avec les données des expériences sur la disparition des antineutrinos dans les réacteurs d

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Auerbach, Scott Sean. "Functional effects of genetic polymorphism and splice variation in human nuclear receptors and their co-activators /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6307.

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Tworoger, Shelley Slate. "Effect of nighttime magnetic field and other exposures on sleep quality in young women /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10953.

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Houdy, Thibaut. "Testing non-standard neutrino interactions from 8B solar neutrino rate measurement with Borexino to characterization of the 144Ce source of the SOX experiment." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC209/document.

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Le détecteur Borexino, situé au laboratoire souterrain du Gran Sasso (LNGS), mesure les neutrinos solaires depuis 10 ans. Parmi les neutrinos solaires, le spectre continu du 8B jusqu’à 17 MeV permet de tester la zone de transition de l’effet de résonance dans la matière dit effet MSW. Cette nouvelle analyse augmente d’un ordre de grandeur la statistique par rapport à la précédente mesure de Borexino publiée en 2011. Pour ce faire, l’ensemble du volume scintillant a été inclus dans l’analyse, aucune coupure géométrique n’ayant été effectué au dessus de 5 MeV. Cela a permis l’identification d’un

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Miettinen, M. (Minna). "17β-hydroxysteroid dehydrogenase types 1 and 2:expression and activities in various tissues and cell lines and effect of the type 1 enzyme on estrogen-dependent growth of breast cancer cells". Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514254163.

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Abstract 17β-Hydroxysteroid dehydrogenases (17HSDs) catalyze the reactions between 17-hydroxy and 17-keto steroids. In the present study, the enzyme activities and tissue distribution of 17HSD type 1, type 2 and type 4 were characterized. Furthermore, the role of 17HSD type 1 in estrogen-dependent growth was studied in MCF-7 breast cancer cells which were stably transfected with type 1 cDNA. Endogenous oxidative 17HSD activity found in COS-m6 monkey kidney cells was first compared with that of human placental 17HSD. Cultured COS-m6 cells exclusively possessed oxidative 17HSD activity, convert

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Söderberg, Ewa. "Experimental septic shock – Effects of endotoxemia with special reference to pathophysiological responses in the pig." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303822.

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Sepsis and septic shock are conditions, with severe outcome or in many cases death. Sepsis is a systemic inflammatory response trigger by bacteraemia but systemic inflammatory response can also be triggered by major trauma, major surgery, pancreatitis, severe burns etc. The systemic inflammatory reaction initiating the evolvement of septic organ dysfunction can be modelled using endotoxin, a Gram-negative bacterial lipopolysaccharide. This thesis used a porcine experimental sepsis model to examine timing of the inflammatory response due to endotoxin infusion (Paper I) and the influence of ster

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Huf, Peter A., and mikewood@deakin edu au. "Androgen metabolism in the Australian lizard Tiliqua Rugosa." Deakin University. School of Sciences, 1989. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051111.134448.

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Nonmammalian vertebrates possess some unusual features in their hormonal systems/ when compared to mammals. As a consequence, they can make an important contribution in investigations concerning the fundamental mechanisms operating in endocrinology. Such studies concerning androgens include inter alia their effects on developmental aspects in the brain of birds and related singing behaviour; the role of neural enzymes in reproductive processes in fish; and the relation between androgens and the stages of spermatogenesis in amphibia, The present thesis examines the biochemistry of androgens in

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Rolim, Fernanda Andreoli. "Effects of no-take marine reserves on fish assemblages in Brazil : an assessment using stereo-videos /." Rio Claro, 2019. http://hdl.handle.net/11449/182582.

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Orientador: Otto Bismarck Fazzano Gadig<br>Abstract: The establishment of no-take marine reserves (NTRs), i.e. areas with total fishing restrictions, has been an alternative worldwide aiming to preserve both biodiversity and ecosystem functions. Brazil has important NTRs with few studies describing their relevance and efficiency for marine life. With this, the central objective of this thesis was to evaluate the effects of NTRs on fish assemblage, testing the hypothesis that the differences in richness, abundance, biomass and fish body size is more explained by protection status than environme

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Strickland, Janae. "The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1781.pdf.

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Carrigan, Amanda. "Sequence and Effects of Glucocorticoid Receptor Nuclear Retention: An Aid to Understanding Nuclear Retention in Other Proteins?" Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19719.

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Corticosteroid ligands activate the glucocorticoid receptor (GR). GR plays a role in glucose homeostasis, adipogenesis, inflammation, and mood and cognitive functions. Understanding the interplay of diverse forms of receptor regulation (including post-translational modification, cofactor interactions, ligand binding, and receptor localization) and their effects is important for understanding and developing more effective treatment for a variety of conditions. Prior to ligand binding, the naïve GR is primarily cytoplasmic, residing in a chaperone complex containing heat-shock proteins and immun

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Petruccelli, Emily Kay. "A tale of two genes controlling behavior in Drosophila: role of DopEcR in ethanol-induced behavior and effects of epilepsy mutations on sleep." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1998.

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Substance abuse and mental health disorders are a leading source of years lost to disability from medical causes worldwide. Unfortunately, for most neurological disorders it is unclear how underlying genetic predispositions govern behavioral response to environmental stressors. Owing to their convenience, genetic tractability, and small brains, the fruit fly, Drosophila melanogaster, has become an invaluable model in which to dissect the neurological basis of conserved complex behaviors. Here, I characterized the respective roles of two genes in alcohol response and sleep behavior. Steroid hor

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