Relevant bibliographies by topics / Steroid

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Steroid'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "Steroid"

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Chow, Renee W. Y., David J. Handelsman, and Martin K. C. Ng. "Minireview: Rapid Actions of Sex Steroids in the Endothelium." Endocrinology 151, no. 6 (April 14, 2010): 2411–22. http://dx.doi.org/10.1210/en.2009-1456.

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The endothelium is a dynamic interface between the blood vessel and the circulating blood that plays a pivotal role in vascular homeostasis. As such, studies on sex steroid regulation of endothelial function are critical to understanding the role of sex steroids in cardiovascular health and disease. The classical model of steroid action involves liganded steroid receptors binding to specific response elements on target genes to regulate gene transcription. In whole organisms, the time lag between steroid administration and observable effects produced by newly synthesized protein is typically in the order of hours to days. And yet, some effects of steroids, such as vasodilatation, occur within seconds to minutes of steroid administration. Studies in multiple cell types have also shown that steroids can cause the rapid initiation of multiple signaling cascades and second messenger systems, prompting investigations into alternate, transcription independent mechanisms of steroid action. Studies of the endothelium over the past two decades have revealed fundamental mechanisms in rapid sex steroid signaling. In particular, endothelium-dependent vasodilatation by estradiol-induced activation of endothelial nitric oxide synthase has proven to be an uniquely informative model to study sex steroid signaling via classical sex steroid receptors localized to the cell membrane. Despite the complexity of feedback and cross talk between rapid sex steroid signaling and other modes of steroid action, recent studies in this field are facilitating the development of steroidal drugs that selectively target the ability of sex steroids to initiate signaling cascades.
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Hammond, Geoffrey L. "Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action." Journal of Endocrinology 230, no. 1 (July 2016): R13—R25. http://dx.doi.org/10.1530/joe-16-0070.

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Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate the non-protein-bound or ‘free’ fractions of circulating steroid hormones that are considered to be biologically active; as such, they can be viewed as the ‘primary gatekeepers of steroid action’. Albumin binds steroids with limited specificity and low affinity, but its high concentration in blood buffers major fluctuations in steroid concentrations and their free fractions. By contrast, SHBG and CBG play much more dynamic roles in controlling steroid access to target tissues and cells. They bind steroids with high (~nM) affinity and specificity, with SHBG binding androgens and estrogens and CBG binding glucocorticoids and progesterone. Both are glycoproteins that are structurally unrelated, and they function in different ways that extend beyond their transportation or buffering functions in the blood. Plasma SHBG and CBG production by the liver varies during development and different physiological or pathophysiological conditions, and abnormalities in the plasma levels of SHBG and CBG or their abilities to bind steroids are associated with a variety of pathologies. Understanding how the unique structures of SHBG and CBG determine their specialized functions, how changes in their plasma levels are controlled, and how they function outside the blood circulation provides insight into how they control the freedom of steroids to act in health and disease.
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Kim, D. H., H. S. Kim, E. S. Kim, S. H. Park, S. J. Kim, K. O. Kim, Y. J. Lee, E. M. Song, and D. S. Kim. "P176 Clinical features of acute severe ulcerative colitis according to steroid dependency: A KASID multicenter study." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i329—i330. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0306.

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Abstract Background Intravenous steroid therapy is the main initial treatment for acute severe ulcerative colitis (ASUC). However, steroid dependence in patients who were treated with intravenous steroid therapy for ASUC is not fully evaluated. We aimed to determine the prevalence and risk factors of corticosteroid dependence after treatment of ASUC. Methods Adult patients who were admitted for the treatment of ASUC satisfying Truelove-Witts criteria from January 2015 to December 2020 were included in the study. Steroid dependence was defined as a failure to taper steroids below 10 mg within 3 months from initiating intravenous therapy or relapse within 3 months after steroid discontinuation. Results Among a total of 140 patients who received intravenous steroids as initial treatment for ASUC, 105 (75.0%) showed a response while 35 (25.0%) were refractory to steroids. Of 105 patients who responded to intravenous steroid therapy, 21 (20.0%) showed steroid dependence during the follow-period. Demographic and clinical variables were not significantly different between steroid-dependent and steroid response groups. However, initial C-reactive protein (CRP) levels in steroid-dependent groups were numerically lower compared with those in the steroid response group with statistical significance (4.4 ± 4.6 mg/dL versus 7.0 ± 6.4 mg/dL, p = 0.04). Conclusion A total of 20.0% of responders to intravenous steroid treatment for ASUC had a steroid dependency during follow-up. The demographic and clinical features of ASUC according to the presence or absence of steroid dependency were similar. Initial CRP levels were low in patients with steroid dependence.
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Singh, Dheerendra, Nupur Sharma, and Rahul Agarwal. "Prevalence of steroid-induced glaucoma among patients suffering from vernal kerato-conjunctivitis in central India." Indian Journal of Clinical and Experimental Ophthalmology 8, no. 3 (October 15, 2022): 363–67. http://dx.doi.org/10.18231/j.ijceo.2022.074.

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The present study is aimed to assess the prevalence of steroid-induced glaucoma in vernal kerato-conjunctivitis patients treated with topical steroids and to determine the association between different types of topical steroids and the presence of steroid-induced glaucoma. This study was conducted as a hospital-based cross-sectional study on patients belonging to the age range of 8 years to18 years who were already diagnosed with vernal kerato-conjunctivitis and were using topical steroids as treatment. Detailed clinical history and ophthalmologic examination were done. Depending upon the potency of steroids and their intra-ocular pressure raising potential, patients were categorized into one of the 4 groups (A, B, C, D). Intra-ocular pressure levels were raised in 32.9% of the patients managed with topical corticosteroids. Steroid-induced glaucoma was observed in 15 (6.1%) of the patients with vernal kerato-conjunctivitis. Steroid-induced glaucoma was significantly associated with prolonged duration of corticosteroids and high potency corticosteroid use (p<0.05). Steroid-induced glaucoma is one of the common complications of injudicious and long-term use of topical corticosteroids particularly high potency steroids. Approximately one-third of the patients on treatment for vernal kerato-conjunctivitis are corticosteroid responders. High potency steroids and prolonged use of steroids are factors associated with steroid-induced glaucoma.
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Okihara, Masaaki, Hironori Takeuchi, Yukiko Kikuchi, Isao Akashi, Yu Kihara, Osamu Konno, Hitoshi Iwamoto, et al. "Individual Lymphocyte Sensitivity to Steroids as a Reliable Biomarker for Clinical Outcome after Steroid Withdrawal in Japanese Renal Transplantation." Journal of Clinical Medicine 10, no. 8 (April 13, 2021): 1670. http://dx.doi.org/10.3390/jcm10081670.

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Recently, steroid reduction/withdrawal regimens have been attempted to minimize the side effects of steroids in renal transplantation. However, some recipients have experienced an increase/resumption of steroid administrations and acute graft rejection (AR). Therefore, we investigated the relationship between the individual lymphocyte sensitivity to steroids and the clinical outcome after steroid reduction/withdrawal. We cultured peripheral blood mononuclear cells (PBMCs) isolated from 24 recipients with concanavalin A (Con A) in the presence of methylprednisolone (MPSL) or cortisol (COR) for four days, and the 50% of PBMC proliferation (IC50) values and the PBMC sensitivity to steroids were calculated. Regarding the experience of steroid increase/resumption and incidence of AR within one year of steroid reduction/withdrawal, the IC50 values of these drugs before transplantation in the clinical event group were significantly higher than those in the event-free group. The cumulative incidence of steroid increase/resumption and AR in the PBMC high-sensitivity groups to these drugs before transplantation were significantly lower than those in the low-sensitivity groups. These observations suggested that an individual’s lymphocyte sensitivity to steroids could be a reliable biomarker to predict the clinical outcome after steroid reduction/withdrawal and to select the patients whose dose of steroids can be decreased and/or withdrawn after transplantation.
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Blue, Jeffrey G., and John A. Lombardo. "STEROIDS AND STEROID-LIKE COMPOUNDS." Clinics in Sports Medicine 18, no. 3 (July 1999): 667–89. http://dx.doi.org/10.1016/s0278-5919(05)70175-7.

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Wiseman, Helen, and Rosanna Duffy. "Steroids, steroid receptors and disease." Trends in Molecular Medicine 7, no. 4 (April 2001): 146–47. http://dx.doi.org/10.1016/s1471-4914(01)01978-5.

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Lin, Kenny, Claire Stewart, Philip Steig, Cameron Brennan, Philip Gutin, and Samuel Selesnick. "Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications." Journal of Neurological Surgery Part B: Skull Base 79, no. 06 (April 13, 2018): 559–68. http://dx.doi.org/10.1055/s-0038-1641752.

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Objectives To determine the incidence of prolonged postoperative systemic corticosteroid therapy after surgery for acoustic neuroma as well as the indications and associated risk factors that could lead to prolonged steroid administration, and the incidence of steroid-related adverse effects. Study Designs Retrospective chart review. Methods Retrospective chart review of patients undergoing resection of acoustic neuroma between 2010 and 2017 at two tertiary care medical centers. Patient and tumor characteristics, operative approach, hospital length of stay, initial postoperative taper length, number of discrete postoperative steroid courses, and postoperative complications were analyzed. Results There were 220 patients (99 male, 121 female) with an average age of 49.4 (range 16–78). There were 124 left-sided tumors and 96 right-sided tumors. Within the group, 191 tumors were operated through a retrosigmoid approach, 25 tumors through a translabyrinthine approach, and 4 tumors with a combined retrosigmoid–translabyrinthine approach under the same anesthetic. In total, 35 (15.9%) patients received an extended initial course of postoperative systemic steroids, defined as a taper longer than 18 days. Twenty six (11.8%) patients received additional courses of systemic steroids after the initial postoperative taper. There were 5 (2.3%) patients who required an extended initial taper as well as additional courses of steroids. Aseptic meningitis, often manifested as headache, was the most common indication for additional steroids (14 cases of prolonged taper and 17 cases of additional courses). None of the patient or tumor factors including age, gender, side, size, and approach were statistically significantly associated with either a prolonged initial steroid taper or additional courses of steroids. An extended hospital length of stay was associated with a prolonged initial steroid taper (p = 0.03), though the initial taper length was not predictive of additional courses of steroids. The cumulative number of days on steroids was associated with need for additional procedures (p < 0.01) as well as steroid-related side effects (p = 0.05). The administration of steroids was not found to significantly improve outcomes in postoperative facial paresis. Steroid-related complications were uncommon, seen in 9.26% of patients receiving steroids, with the most common being psychiatric side effects such as agitation, anxiety, and mood lability. Conclusions Systemic corticosteroids are routinely administered postoperatively for patients undergoing craniotomy for the resection of acoustic neuromas. In a review of 220 patients operated by a single neurotologist, no patient or tumor factors were predictive of requiring prolonged initial steroid taper or additional courses of steroids. The cumulative number of days on systemic steroids was associated with undergoing additional procedures and steroid-related side effects. The most common indications for prolonged or additional steroids were aseptic meningitis, cerebrospinal fluid leak, and facial paresis. Additional steroids for postoperative facial paresis did not significantly improve outcomes. Patient-reported steroid-related complications were infrequent and were most commonly psychiatric including agitation, anxiety, and mood lability.
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Corbin, Charles B., Steven A. Feyrer-Melk, Craig Phelps, and Lisa Lewis. "Anabolic Steroids: A Study of High School Athletes." Pediatric Exercise Science 6, no. 2 (May 1994): 149–58. http://dx.doi.org/10.1123/pes.6.2.149.

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A group of 1,680 high school athletes were studied to determine factors associated with anabolic steroid use. A questionnaire assessed personal factors and steroid use, behavior of others and steroid use, and availability of anabolic steroids. Use rates were 1.1% for females and 2.4% for males. Steroids were more readily available to males, who also reported knowing more steroid users than did females. Older athletes were more likely to consider steroid use, but differences in use rate were not significant from Grade 8 to 12. Using discriminant analysis, significant differences (p < .001) were found for profiles of steroid users and nonusers for both males and females. For both males and females, personal factors such as having considered steroid use, a willingness to use them if they were legal, and a willingness to use them if they could insure success in sports were the most useful in classifying athletes as steroid users versus nonusers.
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Kayes, Mohammad Imrul. "Recent Update in The Management of Childhood Nephrotic Syndrome." Journal of Bangladesh College of Physicians and Surgeons 34, no. 1 (August 8, 2016): 26–32. http://dx.doi.org/10.3329/jbcps.v34i1.29119.

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Nephrotic Syndrome (NS) is a common renal disease seen in children. Children who go into complete remission following treatment with corticosteroids are classified as having steroid sensitive NS. In developed countries over 80% of children with idiopathic NS have steroid sensitive disease. The exact pathogenesis of this condition remains elusive. Podocyte injury and proteinuria are the two main issues in the pathogenesis. Recent studies suggest release of cytokines by T-cells as well as a strong contribution of Bcell immunity. Genetic studies have reported human leucocyte antigen (HLA) class II antigens DR and DQ associations linked to steroid sensitive NS. Most children with steroid sensitive NS have multiple relapses and a significant percentage also develop steroid dependent NS. Diuretic- resistant edema also a clinical problem to manage these patients. These children receive multiple courses of steroids and are at high risk of developing steroid toxicity. Patient with frequent relapses who develop steroid dependency thus require alternative treatment. Steroid resistant NS considers when failure to response within 8 weeks of steroid therapy. Steroids sparing agents used include levamisole, cyclophosphamide, mycophenolate mofetil (MMF), calcineurin inhibitors (cyclosporine and tacrolimus), rituximab and vincristine; these agents have greatly reduced the adverse effects seen with long-term use of steroids; so therapy needs to be individualized to achieve optimal care of each child.J Bangladesh Coll Phys Surg 2016; 34(1): 26-32
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Dissertations / Theses on the topic "Steroid"

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McCarthy, Anna Rose. "Biological Activity of Steroid Analogues:Synthesis and Receptor/Enzyme Interactions." Thesis, University of Canterbury. Chemistry, 2006. http://hdl.handle.net/10092/1293.

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This thesis investigates the biological activity of selected non-steroidal analogues of sex steroid hormones by examining two different effects of analogues on endogenous sex hormone activity. Non-steroidal analogues of sex hormones were synthesised to study their biological interactions with a sex steroid receptor and a sex steroid metabolising enzyme. Chapter One introduces the steroid hormones and their physiology, which leads to a review of the mechanisms by which steroids exert their effects. Their implication in disease is discussed, with particular emphasis on the sex steroids. As the biological activity of steroids is related to their chemical structure, the important features of steroid structure are identified, including the cyclopentanoperhydrophenanthrene nucleus, arrangement of ring substituents and ring junction conformation. The concept of non-steroidal analogues of steroids is introduced, and the harmful or beneficial effects analogues have on endogenous steroid activity are considered. Alteration of steroid activity and its consequences are focussed on two main areas; the potential adverse effects of environmental chemicals which mimic sex steroid activity, and the use of non-steroidal analogues in medicinal chemistry for treating sex steroid related disease. Chapter Two describes an investigation into the 17β-estradiol mimicking activity of non-steroidal analogues. Exogenous chemicals that mimic estradiol are of concern as they may alter endogenous estradiol activity and disrupt endocrine systems. Firstly, an introduction to the field of research concerned with environmental chemicals that mimic steroid hormones is given. The interaction of xenoestrogens with the estrogen receptor is described, as are the methods available for assessing the estrogen mimicking activity of xenoestrogens. The concern for insecticides mimicking estrogen activity is described by reviewing reported activities of insecticides, which leads into a discussion of work carried out as part of this thesis. Metabolites of the pyrethroid insecticides permethrin and cypermethrin, 2.14, 2.15, and 2.16 were synthesised while others were commercially obtained. The interaction of pyrethroid insecticide metabolites with the human estrogen receptor expressed in recombinant yeast (Saccharomyces cerevisiae) was studied, following the establishment and validation of the assay. Metabolites 2.11, 2.12, and 2.14 were found to weakly stimulate estrogen receptor-mediated estradiol responsive gene expression in the yeast assay (105 less active than 17β-estradiol). Since the activity of the metabolites using the yeast assay was greater than for the parent compounds, metabolic pathways need to be considered when assessing the impact of exposure to environmental estrogens. The low estrogenic activity suggests these compounds are not individually contributing significantly to the xenoestrogenic impact on humans, but will add to total xenoestrogen exposure. Chapter Three describes the inhibition of a sex steroid metabolising enzyme, steroid 5a-reductase, by novel non-steroidal compounds. Inhibitors of this enzyme are potentially useful therapeutic agents for regulating the activity of an androgen in prostate disorders. A review of the literature on non-steroidal inhibition of 5a-reductase identified three key structural features known to enhance inhibitor potency; ring substitution, position and nature of ring unsaturation and angular methyl group presence. These features were taken into account in the design of inhibitors synthesised in this thesis (3.55-3.57, 3.59, 3.61, 3.62, 3.110 and 3.111). Inhibitors consisting of non-steroidal 5- or 1-aryl pyridone scaffolds were synthesised to investigate SAR for 4'-substituents. The 5-aryl 1-methyl-2-pyridone/piperidone scaffold of compounds 3.55-3.57 and 3.59 was constructed by Suzuki cross coupling methodology, while the 1-aryl 2-methyl 2,3-dihydro-4-pyridone scaffold of 3.61 and 3.62 was constructed by aza Diels-Alder methodology. Long carbon chain olefin containing tethers 3.107 and 3.108 were synthesised for conjugation to inhibitor 3.57 by cross metathesis to give conjugates 3.110 and 3.111. Compounds 3.55-3.57, 3.59, 3.61, 3.62, 3.110 and 3.111 inhibited the type 1 5a-reductase isozyme expressed by HEK-I cells, with activities comparable to those of related literature compounds. The 1-aryl 2,3-dihydro-4-pyridone 3.62 inhibited both the type 1 and 2 isozymes (expressed by HEK-II cells) of 5a-reductase. The presence of bulky hydrophobic groups (benzoyl, long chain tethers) at the 4' position enhanced the potency of type 1 inhibition by 5-aryl pyridone type compounds in comparison to N,N-diisopropyl- and N-allylacetamide groups. This information provides further understanding of SAR within and across different classes of non-steroidal inhibitors of steroid 5a-reductase towards improved drug design.
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Panter, Grace Heather. "The oestrogenicity of steroids and steroid conjugates to fish." Thesis, Brunel University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246165.

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Awah, Edmund Kpabi. "Regulation of the indoleamines by sex steroids." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1004114.

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Alteration of serum tryptophan leads to parallel alterations in brain tryptophan levels. Such changes in brain tryptophan levels has been shown to lead to mood disturbances. The primary enzyme responsible for altering serum tryptophan levels is the liver cytosolic enzyme, tryptophan pyrrolase. Activation of this enzyme is responsible for the enhanced catabolism of circulating tryptophan. The purpose of the present study was firstly to establish whether there is a link between sex steroids and tryptophan pyrrolase activity especially since sex steroids are also known to cause mood disturbances and secondly to determine the effects of sex steroids on brain indolamine metabolism. The results show that all three sex steroids induce the activity of tryptophan pyrrolase implying that they decrease serum tryptophan levels by the activation of tryptophan pyrrolase, thus making less tryptophan available for uptake by the brain. It was also shown that the sex steroids enhance the uptake of ¹⁴C-tryptophan by brain synatopsomes. In addition, the sex steroids influenced the pattern of metabolism of serotonin by organ cultures of rat pineal glands. It is possible that the sex steroids regulate the availability and uptake of indoleamines in the brain.
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Lund-Pero, Margaretha. "Nonspecific esterases in human tissues evidence for their involvement in steroid metabolism and in carcinogenesis /." Lund : Dept. of Molecular Ecogenetics, the Wallenberg Laboratory, University of Lund, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39781861.html.

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Junker, Julia [Verfasser], and Franz [Akademischer Betreuer] Bracher. "Method development for the analysis of steroids, steroid acids and sterol sulfates in biological samples / Julia Junker ; Betreuer: Franz Bracher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1234389185/34.

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Rebuffat, Alexandre G. Bernasconi Alessio Giacomo Ferdinando. "Steroid mediated gene delivery /." Bern : [s.n.], 2000. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Hejaz, Hatem Amin Moh'd. "The synthesis of steroidal and non-steroidal steroid sulphatase inhibitors for endocrine therapy of breast cancer." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445677.

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Janer, Gual Gemma. "Steroid levels, steroid metabolic pathways and their modulation by endocrine disruptors in invertebrates." Doctoral thesis, Universitat Autònoma de Barcelona, 2005. http://hdl.handle.net/10803/3671.

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El invertebrats constitueixen el 95% de les espècies animals i, com en el cas dels vertebrats, són susceptibles a l'efecte dels disruptors endocrins (DEs). Tot i això, la comprensió d'aquest fenomen està limitada pel desconeixement del sistema endocrí dels invertebrats. L'alteració de la síntesis i metabolisme d'hormones esteroides és un dels possibles mecanismes d'acció dels DEs. En aquesta tesi s'ha caracteritzat el metabolisme d'hormones esteroides en diferents espècies d'invertebrats per tal d'avaluar l'efecte in vitro de DEs en aquestes espècies, i finalment investigar l'efecte in vivo de DEs en els nivells i el metabolisme d'esteroides en espècies d'un filum seleccionat (Mol·lusca). Les espècies investigades (Mollusca: Marisa cornuarietis, Mytilus sp., i/o Crassostrea virginica; Crustacea: Hyalella azteca; i Echinoderma: Paracentrotus lividus) van metabolitzar la testosterona a una sèrie de metabolits de fase I que també són formats per vertebrats, amb l'excepció de 4-androstene-3?,17?-diol, un metabolit format per P. lividus i H. azteca. Una de les diferències més importants amb els vertebrats va ser la baixa contribució de les hidroxilacions en el metabolisme de testosterona, i en el cas dels mol·luscs, el metabolisme d'androstenediona (reducció en 5??en comptes de reducció en 17?). Pel que fa al metabolisme de testosterona de fase II, les sulfotransferases es trobaven en nivells alts en P. lividus, però baixos o indetectables en H. azteca i totes les espècies de mol·luscs investigades. En canvi, tots els invertebrats estudiats presentaven una gran capacitat de conjugació d'hormones esteroides amb àcid grassos, una via que sembla que ha estat ben conservada al llarg de l'evolució. Els nivells d'hormones esteroides i algunes de les vies enzimàtiques que les metabolitzen van mostrar diferències estacionals, entre diferents teixits i entre sexes, fet que recolza la possible funció fisiològica de les hormones esteroides en invertebrats. Alguns xenobiòtics van interferir in vitro amb els enzims que metabolitzen les hormones esteroides. Entre les vies investigades, la 5?-reductasa i la sulfotransferasa, van mostrar la sensibilitat més alta a inhibició/activació per tributilestany (TBT), trifenilestany (TPT) i fenarimol. Per últim es va investigar l'efecte de l'exposició a estradiol, petroli, i la barreja de petroli i compostos alquilfenòlics en bivalves Mytilus sp., i l'exposició a metiltestosterona, TBT, TPT i fenarimol en el gasteròpode M. cornuarietis. El tipus d'efectes induïts per l'estradiol van dependre en gran mesura de la seva concentració. Algunes de les respostes observades en els musclos exposats a petroli o la barreja de petroli i alquilfenols, van ser similars a les que s'havien observat per concentracions altes d'estradiol. En aquests experiments es va observar també el possible rol que juga la conjugació d'esteroides amb àcid grassos en la regulació dels nivells d'esteroides lliures. L'exposició als compostos organoestànnics (TBT i TPT) va causar l'aparició d'imposex i va resultar en una reducció del nivell d'esteroides en forma esterificada en femelles de M. cornuarietis, però no en mascles. Els altres compostos avaluats (metiltestosterona i fenarimol) van induir imposex en femelles, però no van mostrar alteracions en els nivells d'esteroides esterificats, de manera que no es va poder demostrar la connexió entre la davallada dels nivells d'esteroides conjugats amb àcids grassos i el fenomen de l'imposex. L'exposició a TPT va inhibir 5?-reductasa en femelles de M. cornuarietis. Tot i així, cap dels dos organoestànnics va alterar el dimorfisme sexual en el metabolisme d'androstenedione que existeix en el complex glàndula digestiva/gònada d'aquest gasteròpode. En resum, aquesta tesi contribueix al coneixement del metabolisme d'andrògens en invertebrats i identifica dianes on poden actuar els disruptors endocrins.
Ninety-five percent of all animal species are invertebrates, and like vertebrates, they are susceptible to endocrine disruption. Nevertheless, there are important gaps on the knowledge of the endocrine system of invertebrates that hinder the understanding of the endocrine disruption phenomena in those species. Steroid synthesis and metabolism is one of several possible targets of endocrine disruptors. This thesis aimed to characterize sex steroid metabolism in different invertebrate species, to test the in vitro effect of model endocrine disruptors in those species, and to test the in vivo effect of model endocrine disruptors on steroid levels and metabolism in species from a selected phyla (Mollusca). The species investigated (Mollusca: Marisa cornuarietis, Mytilus sp., and/or Crassostrea virginica; Crustacea: Hyalella azteca; and Echinoderma: Paracentrotus lividus) were able to form a series of phase I metabolites of testosterone that are also formed by vertebrates, with the exception of 4-androstene-3?,17?-diol, a metabolite formed by P. lividus and H. azteca. One of the major differences with vertebrate species was the lower contribution of hydroxylases in the metabolism of testosterone, and the metabolic fate of androstenedione in molluscs (5?-reduction instead of 17?-reduction). Regarding phase II metabolism of testosterone, sulfotransferases were found at high levels in P. lividus, but low or undetectable levels were present in H. azteca and the molluscan species investigated. In contrast, the conjugation of steroids with fatty acid moieties was present in all invertebrates investigated, showing that acyl-CoA:steroid acyltransferases are well-conserved through evolution. Steroid levels and the enzymatic activities for some metabolic pathways showed differences between males and females, among tissues, and between seasons in some invertebrate species, which adds further evidence for a physiological role of sex steroids in invertebrates. Some xenobiotics modulated steroid metabolic pathways in invertebrates in vitro. Among the pathways investigated, 5?-reductase and sulfotransferase showed the highest sensitivity to inhibition/activation by tributyltin (TBT), triphenyltin (TPT) and fenarimol. Finally, the effects of the exposure to estradiol, crude oil, and the mixture of crude oil and alkylphenolic compounds in Mytilus sp. and the exposure to methyltestosterone, TBT, TPT and fenarimol in the gastropod M. cornuarietis were investigated. The type of effects induced by estradiol depended greatly on the concentration. Some of the responses observed in mussels exposed to crude oil and the mixture of crude oil and alkylphenols were similar to those observed in mussels exposed to the highest concentrations of estradiol. Those experiments also showed that esterification seems to play a key role in the regulation of free steroid levels in bivalve molluscs. The exposure to the organotin compounds (TBT and TPT) caused imposex and decreased esterified steroid levels in females of M. cornuarietis, but not in males. Methyltestosterone and fenarimol induced imposex in females, but did not lead to alterations in esterified steroid levels. Therefore, the connection between a decrease of esterified steroids and the phenomena of imposex could not be proved. The exposure to TPT inhibited???-reductase in female M. cornuarietis. However, neither TPT nor TBT altered the sexual dimorphism in androstenedione metabolism that exists in the digestive gland/gonad complex of this snail species. Overall, this thesis contributes to the knowledge of androgen metabolism in invertebrate species and identifies possible targets of endocrine disruption.
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Opoku-Edusei, Justicia. "ROLE OF NEWLY SYNTHESIZED STEROID HORMONE ANTAGONISTS IN ADRENOCORTICO-STEROID HORMONE-INDUCED HYPERTENSION." VCU Scholars Compass, 1990. http://scholarscompass.vcu.edu/etd/4986.

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Excess adrenocorticosteroid hormones such as glucocorticoids and mineralocorticoids is well known to induce hypertension in several animal species as well as in humans. Therefore, the development of potent and specific glucocorticoid and mineralocorticoid antagonists with antihypertensive effects is clinically necessary. steroid hormone antagonists being used therapeutically present serious endocrinology side effects such as the widely used antimineralocorticoid, spironolactone. The antiglucocorticoids available so far have been active only in vitro or only weakly in viva. Recently, three new exciting adrenocorticosteroid hormone antagonists have been synthesized. RU 486 is a potent antiglucocorticoid (and antiprogesterone with potential as an abortifacient), RU 26752 and mespirenone, are novel mineralocorticoid antagonists. I studied the antihypertensive effect of RU 486, RU 26752 and mespirenone in Sprague- Dawley rats with dexamethasone- or aldosterone-induced hypertension. In addition, the effect of these antagonists on the hypertension developed by genetic model, spontaneously hypertensive rats (SHR) were also studied. The SHR is the closest animal model to human essential hypertension and it is believed that adrenocorticosteroid hormones are involved in the induction and maintenance of the hypertension. The results obtained from my studies showed that RU 486 administered simultaneously with dexamethasone prevented the hypertension induced by dexamethasone treatment. However, RU 486 had no effect on mineralocorticoid-induced hypertension. The administration of the antimineralocorticoid RU 26752 or mespirenone in combination with aldosterone successfully presented aldosterone-induced hypertension but not dexamethasone- induced hypertension. Surprisingly, RU 486 caused a significant increase in the blood pressure of the SHR whilst mespirenone caused a slight decrease in blood pressure as compared to control SHR. The effect of these antihormones on body/organ weights, fluid intake and urinary output was observed. Morphologically examination of the heart and kidney showed no abnormalities with treatment. These results suggest that 1) RU 486 is specific in preventing dexamethasone-induced hypertension; 2) RU 26752 and mespirenone are successful in preventing aldosterone-induced hypertension and 3) mineralocorticoids may be involved in the development and maintenance of hypertension in the SHR.
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Whitmarsh, Samuel David. "Steroid based toroidal facial amphiphiles." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500447.

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The fields of anion recognition and anion transport are active areas of research within supramolecular chemistry. This project utilised choiic acid as an advanced starting material to produce a family of macrocyclic oligosteroids. The aim was to apply these novel materials to three separate supramolecular applications; firstly, to bind anions, secondly, to form pseudorotaxanes of DNA, and thirdly to effect the transport of anions across membrane bilayers.
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Books on the topic "Steroid"

1

C, Spelsberg T., and Kumar Rajiv 1949-, eds. Steroid and sterol hormone action. Boston: Nijhoff, 1987.

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Spelsberg, T. C., and R. Kumar, eds. Steroid and Sterol Hormone Action. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2073-9.

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S, Görög, ed. Steroid analysis in the pharmaceutical industry: Hormonal steroids, sterols, vitamins D, cardiac glycosides. Chichester, England: E. Horwood, 1989.

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Esteroides. Johnstown, PA: National Drug Intelligence Center, U.S. Dept. of Justice, 2005.

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Makin, Hugh L. J., and D. B. Gower, eds. Steroid Analysis. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1023/b135931.

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Makin, H. L. J., D. B. Gower, and D. N. Kirk, eds. Steroid Analysis. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-017-3078-5.

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Nahar, Lutfun, and Satyajit D. Sarker. Steroid Dimers. Chichester, UK: John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119970934.

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Makin, Hugh L. J., and D. B. Gower, eds. Steroid Analysis. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-1-4020-9775-1.

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Castoria, Gabriella, and Ferdinando Auricchio, eds. Steroid Receptors. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1346-6.

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Steroid blues. New York: Tom Docherty Associates, 1995.

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Book chapters on the topic "Steroid"

1

Lynch, Gordon S., David G. Harrison, Hanjoong Jo, Charles Searles, Philippe Connes, Christopher E. Kline, C. Castagna, et al. "Steroid." In Encyclopedia of Exercise Medicine in Health and Disease, 817. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_3076.

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Gooch, Jan W. "Steroid." In Encyclopedic Dictionary of Polymers, 925. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14864.

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Riesz, M., E. Kárpáti, and L. Szporny. "Steroid Derivatives." In New Neuromuscular Blocking Agents, 301–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70682-0_12.

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Miller, Kathleen E. "Steroid Use." In Encyclopedia of Adolescence, 2868–76. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-1695-2_189.

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Foster, Paul. "Steroid Sulfatase." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_5505-2.

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Greiner, E. F., T. Wintermantel, and G. Schütz. "Steroid Receptors." In Transgenic Models in Pharmacology, 575–606. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18934-0_19.

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Lindzey, Jonathan, and Kenneth S. Korach. "Steroid Hormones." In Endocrinology, 47–62. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-59259-641-6_4.

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Milgrom, Edwin, and Alfred Jost. "Steroid Hormones." In Hormones, 385–442. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3060-8_9.

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Lynch, Gordon S., David G. Harrison, Hanjoong Jo, Charles Searles, Philippe Connes, Christopher E. Kline, C. Castagna, et al. "Steroid Hormones." In Encyclopedia of Exercise Medicine in Health and Disease, 817–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_258.

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Sandor, Z., and S. Szabo. "Steroid Ulcers." In Drug-Induced Injury to the Digestive System, 33–53. Milano: Springer Milan, 1993. http://dx.doi.org/10.1007/978-88-470-2220-1_4.

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Conference papers on the topic "Steroid"

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Chua, Huey Eng, Sourav S. Bhowmick, Lisa Tucker-Kellogg, and C. Forbes Dewey. "STEROID." In the ACM Conference. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2382936.2382937.

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Doan, Jessica, Peter Phommahaxay, Sarah Olson, and Matthew A. Petersen. "Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3254.

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We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.
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Holloway, H., A. J. Moriarty, S. D. Nelson, and K. Balnave. "SERENDIPITOUS PROTECTION FROM PLATELET-MEDIATED DISORDERS IN STEROID-TREATED PATIENTS?" In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643473.

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The aim of this study is to investigate the influence of exogenous corticosteroids on platelet aggregation. This is widely recognised to be of significance in the pathogenesis of acute myocardial infarction and other vascular/haematological disorders.Blood was taken from a cohort of patients (N = 10) undergoing treatment with ACTH or corticosteroids for varied systemic illness. Ex vivo measurements of platelet parameters were made with a Coulter Counter Model S Plus III on nonanticoagulated blood directly from the circulation. Subsequently, aliquots of anticoagulated blood in batches of five were processed at intervals over 24 hours. For comparison, a similar study was undertaken in normal volunteers not on any medication. The mean percentage changes ± standard deviations over the 24 hour interval in platelet count (PLT), mean platelet volume (MPV) and plateletcrit or biomass (PCT) in the respective groups were as follows:-PLT: -(3.12 ± 2.68) vs -(14.77 ± 3.96)(p < 0.001);MPV: 28.88±8.92 vs 46.68±12.54 (p <0.01);PCT: 25.18 ± 8.16 vs 23.75 ± 8.97 (NS).The in vitro alteration in PCT over 24 hours in both cohorts is similar and is due to platelet swelling. The change in MPV is partly due to swelling and partly due to aggregation as evidenced by the decrease in PLT. The significantly smaller drop in PLT and smaller rise in MPV in the steroid-treated group clearly demonstrate that platelets from these patients are less aggregable. A possible cause is that the inhibitory effect of steroids on phospholipase may lead to reduced levels of thromboxane A2. Thus patients on steroid therapy or with high endogenous steroid levels may enjoy serendipitous protection from a variety of platelet mediated disorders. The work may also explain in part why such patients are more prone to bleeding diatheses.
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Jovanović-Šanta, Suzana S., Aleksandar M. Oklješa, Antos B. Sachanka, Yaraslau U. Dzichenka, and Sergei A. Usanov. "17-SUBSTITUTED STEROIDAL TETRAZOLES – NOVEL LIGANDS FOR HUMAN STEROID-CONVERTING CYP ENZYMES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.336js.

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In animal and human organisms, there are many enzymes, members of the family of heme- containing proteins, cytochromes P450 (CYPs), included in the biosynthesis and metabolism of many biomolecules, as cholesterol, bile acids, sex, and corticosteroid hormones, as well as in metabolism of drugs and xenobiotics. It is also well-known that different imidazole and triazole derivatives are efficient inhibitors of CYPs activity. In this study, we present in vitro screening of binding of novel androstane derivatives with tetrazole- containing substituents in position 17 to human recombinant steroid-converting CYP enzymes: CYP7A1, CYP7B1, CYP17A1, CYP19, and CYP21. Initial screening was performed using a high throughput screening approach, while the affinity of the ligands was analyzed using spectrophotometric titration. For some among tested compounds type I spectral response (substrate-like binding) for CYP7A1 selectively, while for one compound type II spectral response (inhibitor-like binding) for CYP21 were detected, with micromolar values of Kds. Interestingly, one compound with mixed spectral response was found to bind for CYP7B1, which means that there are two optimal positions of the ligand inside the protein active site. Such results could be useful in CYP-inhibiting drug development, during a fast, high-throughput screening of pharmacological potential of novel compounds, as well as in side- effects recognizing.
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Harter, S. R., S. Singh, Y. R. Shweihat, and A. Abu-Hashyeh. "Steroid Induced Hypokalemic Periodic Paralysis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4825.

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He, Z., Y. Bin, L. Wu, Y. Liang, J. Bai, J. Zhang, M. Li, and X. Zhong. "Expression of GR-α and HDAC2 in Steroid-Sensitive and Steroid-Insensitive Interstitial Lung Disease." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4772.

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Jones, Matthew, Emily Heiden, Jessica Gates, David Lodge, Ruth De Vos, Rachel Harvey, Scott Elliott, Thomas Brown, Anoop Chauhan, and Hitasha Rupani. "Adherence to steroid treatment in asthma." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4183.

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Pozniak, Hleb, Anna Stoliarchuk, Yaroslav Faletrov, and Vladimir Shkumatov. "In Silico Modeling of the Interaction of NBD Steroids with Insect Steroid-Binding Protein SPC-2." In International Electronic Conference on Synthetic Organic Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecsoc-26-13712.

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Liao, Wupeng, Wan Shun Daniel Tan, and Wai-Shiu Fred Wong. "LATE-BREAKING ABSTRACT: Andrographolide helps steroid-resistant cigarette smoke-induced lung injury model to regain steroid sensitivity." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.oa3535.

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Pinkerton, James, Richard Kim, Ama-Tawiah Essilfie, Brittany Rae, Jemma Mayall, Md Khadem Ali, Malcolm Starkey, et al. "Investigating antioxidant therapy for steroid-resistant asthma." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa570.

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Reports on the topic "Steroid"

1

Wallace, Margaret R. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada443895.

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Wallace, Margaret R., David Muir, and Martha Campbell-Thompson. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2004. http://dx.doi.org/10.21236/ada428454.

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Wallace, Margaret R., David Muir, and Martha Campbell-Thompson. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada411283.

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T. Borges, G. Eisele, and C. Byrd. Review of Androgenic Anabolic Steroid Use. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/783604.

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Isaacs, Jonathan E. Anabolic Steroid Reversal of Denervation Atrophy. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada562447.

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Jeng, Meei-Huey. Roles of Steroid Receptor Coactivators in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada404705.

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Jeng, Meei-Hue Y. Roles of Steroid Receptor Coactivators in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, January 2004. http://dx.doi.org/10.21236/ada426309.

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Jeng, Meei-Huey. Roles of Steroid Receptor Coactivators in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2003. http://dx.doi.org/10.21236/ada423247.

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Hagerman, Randi. Treatment of Fragile X Syndrome with a Neuroactive Steroid. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada613986.

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Hagerman, Randi. Treatment of Fragile X Syndrome with a Neuroactive Steroid. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada580938.

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