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Journal articles on the topic 'Steroid metabolomics'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Kotłowska, Alicja, and Piotr Szefer. "Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery." Current Medicinal Chemistry 26, no. 1 (2019): 29–45. http://dx.doi.org/10.2174/0929867324666171113120810.

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Background: Steroid hormones belong to a group of low-molecular weight compounds which are responsible for maintenance of various body functions, thus, their accurate assessment is crucial for evaluation of biosynthetic defects. The development of reliable methods allowing disease diagnosis is essential to improve early detection of various disorders connected with altered steroidogenesis. Currently, the field of metabolomics offers several improvements in terms of sensitivity and specificity of the diagnostic methods when opposed to classical diagnostic approaches. The combination of hyphenat

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Ferraro, Valentina Agnese, Silvia Carraro, Paola Pirillo, et al. "Breathomics in Asthmatic Children Treated with Inhaled Corticosteroids." Metabolites 10, no. 10 (2020): 390. http://dx.doi.org/10.3390/metabo10100390.

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Background: “breathomics” enables indirect analysis of metabolic patterns underlying a respiratory disease. In this study, we analyze exhaled breath condensate (EBC) in asthmatic children before (T0) and after (T1) a three-week course of inhaled beclomethasone dipropionate (BDP). Methods: we recruited steroid-naive asthmatic children for whom inhaled steroids were indicated and healthy children, evaluating asthma control, spirometry and EBC (in asthmatics at T0 and T1). A liquid-chromatography–mass-spectrometry untargeted analysis was applied to EBC and a mass spectrometry-based target analysi

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Hagenbeek, Fiona A., Jenny van Dongen, René Pool, et al. "Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children." Metabolites 12, no. 6 (2022): 474. http://dx.doi.org/10.3390/metabo12060474.

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Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7–12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the

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Lee, Yu Ra, Eunju Im, Haksoon Kim, et al. "Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year." Metabolites 10, no. 4 (2020): 131. http://dx.doi.org/10.3390/metabo10040131.

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Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production. In this study, we aimed to identify metabolic differences in urinary metabolomics profiles between MPB patients after a one-year treatment with finasteride and healthy controls. Untargeted and targeted metabolomics profiling was performed using liquid chromatography-mass spectrometry (LC-MS). We hypothesized that there would be changes in overall metabolite concentrations, especially steroids, in the urine of hair loss pa

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Chortis, Vasileios, Irina Bancos, Thomas Nijman, et al. "Urine Steroid Metabolomics as a Novel Tool for Detection of Recurrent Adrenocortical Carcinoma." Journal of Clinical Endocrinology & Metabolism 105, no. 3 (2019): e307-e318. http://dx.doi.org/10.1210/clinem/dgz141.

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Abstract Context Urine steroid metabolomics, combining mass spectrometry-based steroid profiling and machine learning, has been described as a novel diagnostic tool for detection of adrenocortical carcinoma (ACC). Objective, Design, Setting This proof-of-concept study evaluated the performance of urine steroid metabolomics as a tool for postoperative recurrence detection after microscopically complete (R0) resection of ACC. Patients and Methods 135 patients from 14 clinical centers provided postoperative urine samples, which were analyzed by gas chromatography–mass spectrometry. We assessed th

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Valko-Rokytovská, Marcela, Peter Očenáš, Aneta Salayová, and Zuzana Kostecká. "Breast Cancer: Targeting of Steroid Hormones in Cancerogenesis and Diagnostics." International Journal of Molecular Sciences 22, no. 11 (2021): 5878. http://dx.doi.org/10.3390/ijms22115878.

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Breast cancer is the most common malignancy in women with high mortality. Sensitive and specific methods for the detection, characterization and quantification of endogenous steroids in body fluids or tissues are needed for the diagnosis, treatment and prognosis of breast cancer and many other diseases. At present, non-invasive diagnostic methods are gaining more and more prominence, which enable a relatively fast and painless way of detecting many diseases. Metabolomics is a promising analytical method, the principle of which is the study and analysis of metabolites in biological material. It

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Yan, Ruifeng, Shaoyang Ji, Tingting Ku, and Nan Sang. "Cross-Omics Analyses Reveal the Effects of Ambient PM2.5 Exposure on Hepatic Metabolism in Female Mice." Toxics 12, no. 8 (2024): 587. http://dx.doi.org/10.3390/toxics12080587.

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Ambient particulate matter (PM2.5) is a potential risk factor for metabolic damage to the liver. Epidemiological studies suggest that elevated PM2.5 concentrations cause changes in hepatic metabolism, but there is a lack of laboratory evidence. Here, we aimed to evaluate the effects of PM2.5 exposure on liver metabolism in C57BL/6j female mice (10 months old) and to explore the mechanisms underlying metabolic alterations and differential gene expressions by combining metabolomics and transcriptomics analyses. The metabolomics results showed that PM2.5 exposure notably affected the metabolism o

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Anlar, Gulsen Guliz, Najeha Anwardeen, Sarah Al Ashmar, Shona Pedersen, Mohamed A. Elrayess, and Asad Zeidan. "Metabolomics Profiling of Stages of Coronary Artery Disease Progression." Metabolites 14, no. 6 (2024): 292. http://dx.doi.org/10.3390/metabo14060292.

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Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are key contributors to CAD development. Metabolomics, with its comprehensive analysis of metabolites, offers a unique perspective on cardiovascular diseases. This study leveraged metabolomics profiling to investigate the progression of CAD, focusing on the interplay of hypercholesterolemia, hypertension, and diabetes. We performed a metabolomic analysis on 221 participants from

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Lee, Yu Ra, Ki-Yong An, Justin Jeon, et al. "Untargeted Metabolomics and Polyamine Profiling in Serum before and after Surgery in Colorectal Cancer Patients." Metabolites 10, no. 12 (2020): 487. http://dx.doi.org/10.3390/metabo10120487.

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Colorectal cancer is one of the most prevalent cancers in Korea and globally. In this study, we aimed to characterize the differential serum metabolomic profiles between pre-operative and post-operative patients with colorectal cancer. To investigate the significant metabolites and metabolic pathways associated with colorectal cancer, we analyzed serum samples from 68 patients (aged 20–71, mean 57.57 years). Untargeted and targeted metabolomics profiling in patients with colorectal cancer were performed using liquid chromatography-mass spectrometry. Untargeted analysis identified differences i

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Kim, Dong-Wook, Quynh-An Nguyen, Saoraya Chanmuang, et al. "Effects of Kimchi Intake on the Gut Microbiota and Metabolite Profiles of High-Fat-Induced Obese Rats." Nutrients 16, no. 18 (2024): 3095. http://dx.doi.org/10.3390/nu16183095.

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With rising global obesity rates, the demand for effective dietary strategies for obesity management has intensified. This study evaluated the potential of kimchi with various probiotics and bioactive compounds as a dietary intervention for high-fat diet (HFD)-induced obesity in rats. Through a comprehensive analysis incorporating global and targeted metabolomics, gut microbiota profiling, and biochemical markers, we investigated the effects of the 12-week kimchi intake on HFD-induced obesity. Kimchi intake modestly mitigated HFD-induced weight gain and remarkably altered gut microbiota compos

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Moon, Ju-Yeon, Man Ho Choi, and Jayoung Kim. "Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases." Endocrine-Related Cancer 23, no. 10 (2016): R455—R467. http://dx.doi.org/10.1530/erc-16-0285.

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Cholesterol and sex steroid hormones including androgens and estrogens play a critical role in the development and progression of urological diseases such as prostate cancer. This disease remains the most commonly diagnosed malignant tumor in men and is the leading cause of death from different cancers. Attempts to understand the role of cholesterol and steroid metabolism in urological diseases have been ongoing for many years, but despite this, our mechanistic and translational understanding remains elusive. In order to further evaluate the problem, we have taken an interest in metabolomics;

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Pozo, Oscar J., Josep Marcos, Olha Khymenets, et al. "SULFATION PATHWAYS: Alternate steroid sulfation pathways targeted by LC–MS/MS analysis of disulfates: application to prenatal diagnosis of steroid synthesis disorders." Journal of Molecular Endocrinology 61, no. 2 (2018): M1—M12. http://dx.doi.org/10.1530/jme-17-0286.

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The steroid disulfates (akabis-sulfates) are a significant but minor fraction of the urinary steroid metabolome that have not been widely studied because major components are not hydrolyzed by the commercial sulfatases commonly used in steroid metabolomics. In early studies, conjugate fractionation followed by hydrolysis using acidified solvent (solvolysis) was used for the indirect detection of this fraction by GC–MS. This paper describes the application of a specific LC–MS/MS method for the direct identification of disulfates in urine, and their use as markers for the prenatal diagnosis of d

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Xia, Tianshuang, Xin Dong, Yiping Jiang, et al. "Metabolomics Profiling Reveals Rehmanniae Radix Preparata Extract Protects against Glucocorticoid-Induced Osteoporosis Mainly via Intervening Steroid Hormone Biosynthesis." Molecules 24, no. 2 (2019): 253. http://dx.doi.org/10.3390/molecules24020253.

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Rehmanniae Radix Preparata (RR), the dry rhizome of Rehmannia glutinosa Libosch., is a traditional herbal medicine for improving the liver and kidney function. Ample clinical and pharmacological experiments show that RR can prevent post-menopausal osteoporosis and senile osteoporosis. In the present study, in vivo and in vitro experiments, as well as a UHPLC-Q/TOF-MS-based metabolomics study, were used to explore the preventing effect of RR on glucocorticoid-induced osteoporosis (GIOP) and its underlying mechanisms. As a result, RR significantly enhanced bone mineral density (BMD), improved th

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Lim, Jungeun, Hyokyoung G. Hong, Stephanie J. Weinstein, et al. "Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial." Nutrients 15, no. 13 (2023): 2836. http://dx.doi.org/10.3390/nu15132836.

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The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C22 lactone sulfate compound, androgenic steroids, and other metabolites. A total of 3409 women and men previously selected for metabolomics studies in the PLCO Cancer Screening Trial were included in this investigation. Serum metabolites were profiled using ultrahigh-performance liquid and gas chromatography/tandem mass spectrometry. Seventy known metabolites inclu

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Liu, Ying-Hao, Qian Gong, Yi-Kai Wang, and Wei-Bing Shuang. "Time-Dependent Changes in the Bladder Muscle Metabolome After Traumatic Spinal Cord Injury in Rats Using Metabolomics." International Neurourology Journal 27, no. 2 (2023): 88–98. http://dx.doi.org/10.5213/inj.2346068.034.

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Purpose: The main treatment options of neurogenic bladder remains catheterization and long-term oral medications. Metabolic interventions have shown good therapeutic results in many diseases. To date, no studies have characterized the metabolites of the detrusor muscle during neurogenic bladder. Using metabolomics, new muscle metabolomic signatures were identified to reveal the temporal metabolic profile of muscle during disease progression.Methods: We used 42 Sprague-Dawley rats (200±20 g, males) for T10 segmental spinal cord injury modeling and collected detrusor tissue and performed nontarg

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Zhou, Lin, Youming Cai, Liuyan Yang, Zhongwei Zou, Jiao Zhu, and Yongchun Zhang. "Comparative Metabolomics Analysis of Stigmas and Petals in Chinese Saffron (Crocus sativus) by Widely Targeted Metabolomics." Plants 11, no. 18 (2022): 2427. http://dx.doi.org/10.3390/plants11182427.

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The dried stigmas of Crocus sativus, commonly known as saffron, are consumed largely worldwide because it is highly valuable in foods and has biological activities beneficial for health. Saffron has important economic and medicinal value, and thus, its planting area and global production are increasing. Petals, which are a by-product of the stigmas, have not been fully utilized at present. We compared the metabolites between the stigmas and petals of C. sativus using a non-targeted metabolomics method. In total, over 800 metabolites were detected and categorized into 35 classes, including alka

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Storbeck, Karl-Heinz, Lina Schiffer, Elizabeth S. Baranowski, et al. "Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism." Endocrine Reviews 40, no. 6 (2019): 1605–25. http://dx.doi.org/10.1210/er.2018-00262.

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Abstract Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of underlying conditions. Mass spectrometry–based steroid metabolome profiling has allowed for the identification of unique multisteroid signatures associated with disorders of steroid biosynthesis and metabolism that can be used for personalized approaches to diagnosis, differential diagnosis, and prognostic prediction. Additionally, steroid metabolo

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Jiang, Wu, Lingling Jiang, Xiaoli Yin, et al. "Untargeted Metabolomics Reveals the Metabolic Characteristics and Biomarkers of Antioxidant Properties of Gardeniae Fructus from Different Geographical Origins in China." Metabolites 15, no. 1 (2025): 38. https://doi.org/10.3390/metabo15010038.

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Background/Objectives: Gardeniae Fructus (GF) has been widely used as both food and medicinal purposes for thousands of years, but their antioxidant properties and potential metabolite biomarkers remain unclear. Methods: The purposes of this study were to examine antioxidant activities of 21 GF varieties from different geographical origins in China and identify potential biomarkers of antioxidant properties using an untargeted LC–MS-based metabolomics approach. Results: The results demonstrate that metabolomics had the ability to trace the geographical origins of GF. We found that antioxidant

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Lee, Yu Ra, Bark Lynn Lew, Woo Young Sim, Jongki Hong, and Bong Chul Chung. "Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach." Metabolites 11, no. 3 (2021): 178. http://dx.doi.org/10.3390/metabo11030178.

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Pattern baldness has been associated with the male hormone, dihydrotestosterone. In this study, we tried to determine how the overall metabolic pathways of pattern baldness differ in patients and in normal controls. Our study aimed to identify alterations in hair metabolomic profiles in order to identify possible markers of pattern baldness according to sex. Untargeted metabolomics profiling in pattern baldness patients and control subjects was conducted using ultra-performance liquid chromatography-mass spectrometry. To identify significantly altered metabolic pathways, partial least squares

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Reinke, Stacey N., Héctor Gallart-Ayala, Cristina Gómez, et al. "Metabolomics analysis identifies different metabotypes of asthma severity." European Respiratory Journal 49, no. 3 (2017): 1601740. http://dx.doi.org/10.1183/13993003.01740-2016.

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In this study, we sought to determine whether asthma has a metabolic profile and whether this profile is related to disease severity.We characterised the serum from 22 healthy individuals and 54 asthmatics (12 mild, 20 moderate, 22 severe) using liquid chromatography–high-resolution mass spectrometry-based metabolomics. Selected metabolites were confirmed by targeted mass spectrometry assays of eicosanoids, sphingolipids and free fatty acids.We conclusively identified 66 metabolites; 15 were significantly altered with asthma (p≤0.05). Levels of dehydroepiandrosterone sulfate, cortisone, cortis

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Olesti, Eulàlia, Ilario De Toma, Johannes G. Ramaekers, et al. "Metabolomics predicts the pharmacological profile of new psychoactive substances." Journal of Psychopharmacology 33, no. 3 (2018): 347–54. http://dx.doi.org/10.1177/0269881118812103.

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Background: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large number of new compounds released on the market each year, their timely evaluation by current standards is certainly challenging. Aims: We present here a metabolomics-targeted approach to predict the pharmacological profile of NPS. Methods: We have created a machine learning algorithm employing the quantification of monoamine neurotransmitters and stero

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Zhang, Min, Xiaoying Zou, Yixuan Du, et al. "Integrated Transcriptomics and Metabolomics Reveal the Mechanism of Alliin in Improving Hyperlipidemia." Foods 12, no. 18 (2023): 3407. http://dx.doi.org/10.3390/foods12183407.

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This research aims to assess the anti-hyperlipidemia effects of alliin in vivo and its potential mechanisms through transcriptomics and metabolomics analysis. A hyperlipidemia mode was established in C57BL/6 mice fed a high-fat diet, and the related physiological parameters of the animals were recorded. Serum TC and MDA in livers significantly decreased by 12.34% and 29.59%, respectively, and SOD and CAT in livers significantly increased by 40.64% and 39.05%, respectively, after high doses of alliin interventions. In total, 148 significantly different genes, particularly Cel, Sqle, Myc, and Ug

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Sidorina, Anna, Giulio Catesini, Elisa Sacchetti, Cristiano Rizzo, and Carlo Dionisi-Vici. "Propionic Acidemia, Methylmalonic Acidemia, and Cobalamin C Deficiency: Comparison of Untargeted Metabolomic Profiles." Metabolites 14, no. 8 (2024): 428. http://dx.doi.org/10.3390/metabo14080428.

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Methylmalonic acidemia (MMA), propionic acidemia (PA), and cobalamin C deficiency (cblC) share a defect in propionic acid metabolism. In addition, cblC is also involved in the process of homocysteine remethylation. These three diseases produce various phenotypes and complex downstream metabolic effects. In this study, we used an untargeted metabolomics approach to investigate the biochemical differences and the possible connections among the pathophysiology of each disease. The significantly changed metabolites in the untargeted urine metabolomic profiles of 21 patients (seven MMA, seven PA, s

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Stastny, Kamil, Kristina Putecova, Lenka Leva, Milan Franek, Petr Dvorak, and Martin Faldyna. "Profiling of Metabolomic Changes in Plasma and Urine of Pigs Caused by Illegal Administration of Testosterone Esters." Metabolites 10, no. 8 (2020): 307. http://dx.doi.org/10.3390/metabo10080307.

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The use of anabolic steroid hormones as growth promoters in feed for farm animals has been banned in the European Union since 1988 on the basis of Council Directive 96/22/EC. However, there is still ongoing monitoring and reporting of positive findings of these banned substances in EU countries. The aim of this work was to investigate the efficacy and discriminatory ability of metabolic fingerprinting after the administration of 17β-testosterone esters to pigs. Plasma and urine samples were chromatographically separated on a Hypersil Gold C18 column. High resolution mass spectrometry metabolom

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Kogelman, Lisette J. A., Madeleine Ernst, Katrine Falkenberg, et al. "Multi-omics to predict changes during cold pressor test." BMC Genomics 23, no. 1 (2022): 759. https://doi.org/10.1186/s12864-022-08981-z.

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<strong>Background: </strong>The cold pressor test (CPT) is a widely used pain provocation test to investigate both pain tolerance and cardiovascular responses. We hypothesize, that performing multi-omic analyses during CPT gives the opportunity to home in on molecular mechanisms involved. Twenty-two females were phenotypically assessed before and after a CPT, and blood samples were taken. RNA-Sequencing, steroid profiling and untargeted metabolomics were performed. Each 'omic level was analyzed separately at both single-feature and systems-level (principal component [PCA] and partial least sq

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Sun, Na, Thomas Kunzke, Silviu Sbiera, et al. "Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging." Clinical Chemistry 65, no. 10 (2019): 1276–86. http://dx.doi.org/10.1373/clinchem.2019.306043.

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Abstract BACKGROUND Adrenocortical carcinoma (ACC) is a rare tumor with variable prognosis even within the same tumor stage. Cancer-related sex hormones and their sulfated metabolites in body fluids can be used as tumor markers. The role of steroid sulfation in ACC has not yet been studied. MALDI mass spectrometry imaging (MALDI-MSI) is a novel tool for tissue-based chemical phenotyping. METHODS We performed phenotyping of formalin-fixed, paraffin-embedded tissue samples from 72 ACC by MALDI-MSI at a metabolomics level. RESULTS Tumoral steroid hormone metabolites—estradiol sulfate [hazard rati

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Basit, Abdul, Hay Young Zhang, Deepak Kumar Bhatt, John K. Amory, and Bhagwat Prasad. "Effect of oral testosterone on the plasma steroid metabolomics in humans." Drug Metabolism and Pharmacokinetics 33, no. 1 (2018): S58. http://dx.doi.org/10.1016/j.dmpk.2017.11.196.

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He, Ruifen, Zhongying Zhao, Yongxiu Yang, and Xiaolei Liang. "Using bioinformatics and metabolomics to identify altered granulosa cells in patients with diminished ovarian reserve." PeerJ 8 (August 28, 2020): e9812. http://dx.doi.org/10.7717/peerj.9812.

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Background During fertility treatment, diminished ovarian reserve (DOR) is a challenge that can seriously affect a patient’s reproductive potential. However, the pathogenesis of DOR is still unclear and its treatment options are limited. This study aimed to explore DOR’s molecular mechanisms. Methods We used R software to analyze the mRNA microarray dataset E-MTAB-391 downloaded from ArrayExpress, screen for differentially expressed genes (DEGs), and perform functional enrichment analyses. We also constructed the protein-protein interaction (PPI) and miRNA-mRNA networks. Ovarian granulosa cell

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Faquih, Tariq, Bing Yu, Robert Kaplan, et al. "0032 Metabolomic Profile of Excessive Daytime Sleepiness in the Hispanic Community Health Study/Study of Latinos." SLEEP 47, Supplement_1 (2024): A14—A15. http://dx.doi.org/10.1093/sleep/zsae067.0032.

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Abstract Introduction Excessive daytime sleepiness (EDS) is a prevalent condition estimated to affect up to 33% of the United States population. EDS is a heterogeneous and complex symptom of various sleep disorders, insufficient sleep, and other chronic conditions and medications. EDS has also been associated with increased risk of cardiovascular and neuropsychiatric diseases, potentially through bidirectional causal pathways. In this study, we used metabolomic measurements in 6071 individuals from the Hispanic Community Health Study/Study of Latinos to elucidate the metabolomic factors associ

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Tiosano, Dov, Carlos Knopf, Ilana Koren та ін. "Metabolic evidence for impaired 17α-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity". European Journal of Endocrinology 158, № 3 (2008): 385–92. http://dx.doi.org/10.1530/eje-07-0712.

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ContextThe CYP17A1 gene encodes many enzymatic reactions including 17α-hydroxylase and 17,20-lyase activities. Mutations that selectively ablate the 17,20-lyase activity, causing isolated 17,20-lyase deficiency, are exceedingly rare and may belong to the rarest of all disorders of steroidogenesis. We have previously reported an E305G mutation in the active site of CYP17A1 that apparently causes isolated 17,20-lyase deficiency. Expression studies suggested intact 17α-hydroxylase activity which was at odds with subnormal tetracosactrin stimulated cortisol in the patients.ObjectivesTo investigate

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Gong, Yujie, Xiaoting Zou, Wenrui Xia, et al. "Comparative metabolomic analysis of caecal digesta between Jinhua pig and Landrace pig." Czech Journal of Animal Science 64, No. 8 (2019): 332–42. http://dx.doi.org/10.17221/43/2018-cjas.

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The metabolic difference in caecal digesta between Jinhua pig and Landrace pig was compared. Twenty weaned piglets at 28 days of age, including ten Landrace pigs (a Western pig breed) and ten Jinhua pigs (a Chinese native pig breed), were randomly selected and allocated into two groups. The pigs were fed the same corn-soybean diet on the same pig farm. At the age of 240 days, all pigs of each group were slaughtered, the digesta in the caecum of the twenty pigs were collected for metabolomic analysis and determination of short-chain fatty acids (SCFAs). The results showed that a total of 56 dif

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García-Domínguez, Ximo, Gianfranco Diretto, David S. Peñaranda, et al. "Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit." International Journal of Molecular Sciences 22, no. 18 (2021): 9716. http://dx.doi.org/10.3390/ijms22189716.

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Embryo manipulation is a requisite step in assisted reproductive technology (ART). Therefore, it is of great necessity to appraise the safety of ART and investigate the long-term effect, including lipid metabolism, on ART-conceived offspring. Augmenting our ART rabbit model to investigate lipid metabolic outcomes in offspring longitudinally, we detected variations in hepatic DNA methylation ART offspring in the F3 generation for embryonic exposure (multiple ovulation, vitrification and embryo transfer). Through adult liver metabolomics and proteomics, we identified changes mainly related to li

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Rijk, Jeroen C. W., Arjen Lommen, Martien L. Essers, et al. "Metabolomics Approach to Anabolic Steroid Urine Profiling of Bovines Treated with Prohormones." Analytical Chemistry 81, no. 16 (2009): 6879–88. http://dx.doi.org/10.1021/ac900874m.

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Kotłowska, Alicja. "Application of Steroid Hormone Metabolomics in Search of Biomarkers in Clinical Research." Drug Development Research 73, no. 7 (2012): 381–89. http://dx.doi.org/10.1002/ddr.21028.

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Gooding, Jessica R., Shipra Agrawal, Susan McRitchie, et al. "Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics." Kidney International Reports 5, no. 1 (2020): 81–93. http://dx.doi.org/10.1016/j.ekir.2019.09.010.

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Muroya, Susumu, Yi Zhang, Kounosuke Otomaru, et al. "Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver." Metabolites 12, no. 3 (2022): 203. http://dx.doi.org/10.3390/metabo12030203.

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This study aimed to understand the mechanisms underlying the effects of maternal undernutrition (MUN) on liver growth and metabolism in Japanese Black fetal calves (8.5 months in utero) using an approach that integrates metabolomics and transcriptomics. Dams were fed 60% (low-nutrition; LN) or 120% (high-nutrition; HN) of their overall nutritional requirements during gestation. We found that MUN markedly decreased the body and liver weights of the fetuses; metabolomic analysis revealed that aspartate, glycerol, alanine, gluconate 6-phosphate, and ophthalmate levels were decreased, whereas UDP-

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Xiao, Lige, Guanteng Yang, Hongqi Zhang, Jinyang Liu, Chaofeng Guo, and Yang Sun. "Nontargeted Metabolomic Analysis of Plasma Metabolite Changes in Patients with Adolescent Idiopathic Scoliosis." Mediators of Inflammation 2021 (May 25, 2021): 1–11. http://dx.doi.org/10.1155/2021/5537811.

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Objective. Adolescent idiopathic scoliosis (AIS) is a relatively common spinal rotation deformity, and the pathogenesis of AIS is accompanied by metabolic dysfunction and changes in biochemical factors. In this study, plasma metabolite changes in AIS patients were analyzed based on nontargeted metabolomics to provide new insights for clarifying functional metabolic abnormalities in AIS patients. Methods. Clinical indexes and blood samples were collected from 12 healthy subjects and 16 AIS patients. Metabolomics was used to analyze the changes in metabolites in plasma samples. The correlation b

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Kim, Bora, Ju-Yeon Moon, Man Ho Choi, et al. "Global Metabolomics and Targeted Steroid Profiling Reveal That Rifampin, a Strong Human PXR Activator, Alters Endogenous Urinary Steroid Markers." Journal of Proteome Research 12, no. 3 (2013): 1359–68. http://dx.doi.org/10.1021/pr301021p.

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Popov, Roman S., Natalia V. Ivanchina, and Pavel S. Dmitrenok. "Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds." Marine Drugs 20, no. 5 (2022): 320. http://dx.doi.org/10.3390/md20050320.

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Today, marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention; however, studying these compounds by conventional methods is challenging. The application of modern MS-based approaches can help to obtain valuable information about such compounds. This review provides an up-to-date overview of MS-based applications for starfish and sea cuc

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Carlson, Nicole S., Jennifer K. Frediani, Elizabeth J. Corwin, Anne Dunlop, and Dean Jones. "Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index." American Journal of Perinatology Reports 10, no. 01 (2020): e68-e77. http://dx.doi.org/10.1055/s-0040-1702928.

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Abstract Objectives The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia. Study Design Matched case–control study (n = 97; 48 cases of term labor dystocia and 49 normal labor progression controls) with selection based on body mass index (BMI) at hospital admission and maternal age. Late pregnancy serum samples were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolic features and pathways between cases experiencing term labor dystocia and normal

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Berke, Kristina, Georgiana Constantinescu, Jimmy Masjkur, et al. "Plasma Steroid Profiling in Patients With Adrenal Incidentaloma." Journal of Clinical Endocrinology & Metabolism 107, no. 3 (2021): e1181-e1192. http://dx.doi.org/10.1210/clinem/dgab751.

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Abstract Context Most patients with adrenal incidentaloma have nonfunctional lesions that do not require treatment, while others have functional or malignant tumors that require intervention. The plasma steroid metabolome may be useful to assess therapeutic need. Objective This work aimed to establish the utility of plasma steroid profiling combined with metanephrines and adrenal tumor size for the differential diagnosis of patients with adrenal incidentaloma. Methods This retrospective cross-sectional study, which took place at 7 European tertiary-care centers, comprised 577 patients with adr

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Reinehr, Thomas, Alexandra Kulle, Juliane Rothermel, et al. "Longitudinal analyses of the steroid metabolome in obese PCOS girls with weight loss." Endocrine Connections 6, no. 4 (2017): 213–24. http://dx.doi.org/10.1530/ec-17-0051.

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Objective The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. Design This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13–16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI and change of weight status. Methods We measured progesterone, 17-hydroxyprogesterone, 17-hydroxyprogenolon, 11-deoxycorticosterone, 21-deoxycorticost

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Schteingart, D. E. "Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors." Yearbook of Endocrinology 2012 (January 2012): 255–56. http://dx.doi.org/10.1016/j.yend.2012.05.017.

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Arlt, Wiebke, Michael Biehl, Angela E. Taylor, et al. "Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors." Journal of Clinical Endocrinology & Metabolism 96, no. 12 (2011): 3775–84. http://dx.doi.org/10.1210/jc.2011-1565.

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Fahey, T. J. "Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors." Yearbook of Surgery 2012 (January 2012): 183–84. http://dx.doi.org/10.1016/j.ysur.2012.03.043.

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Boettcher, Claudia, Michaela F. Hartmann, Jan de Laffolie, Klaus-Peter Zimmer, and Stefan A. Wudy. "Absent Adrenarche in Children with Hypopituitarism: A Study Based on Urinary Steroid Metabolomics." Hormone Research in Paediatrics 79, no. 6 (2013): 356–60. http://dx.doi.org/10.1159/000351705.

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Labus, Jennifer S., Emeran A. Mayer, Kjersti Aagaard, Jean Stains, Katarzyna Broniowska, and Andrea Rapkin. "Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An exploratory metabolomics study." Molecular Pain 17 (January 2021): 174480692110418. http://dx.doi.org/10.1177/17448069211041853.

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Provoked vestibulodynia (PVD) is a chronic vulvar pain disorder characterized by hypersensitivity and severe pain with pressure localized to the vulvar vestibule. Knowledge regarding pathophysiological mechanisms contributing to the etiology and production of symptoms in PVD remains incomplete but is considered multifactorial. Using a cross-sectional observational study design, data from untargeted metabolomic profiling of vaginal fluid and plasma in women with PVD and healthy women was combined with pain testing and brain imaging in women with PVD to test the hypotheses that women with PVD co

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Hwangbo, Nathan, Xinyu Zhang, Daniel Raftery, et al. "Predictive Modeling of Alzheimer’s and Parkinson’s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid." Metabolites 12, no. 4 (2022): 277. http://dx.doi.org/10.3390/metabo12040277.

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In recent years, metabolomics has been used as a powerful tool to better understand the physiology of neurodegenerative diseases and identify potential biomarkers for progression. We used targeted and untargeted aqueous, and lipidomic profiles of the metabolome from human cerebrospinal fluid to build multivariate predictive models distinguishing patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), and healthy age-matched controls. We emphasize several statistical challenges associated with metabolomic studies where the number of measured metabolites far exceeds sample size. We fou

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Qiu, Chenyu, Jiawen Liao, Roya Gheissari, et al. "Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight." International Journal of Obesity, April 17, 2025. https://doi.org/10.1038/s41366-025-01775-9.

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Abstract Objective This study aims to find maternal and neonatal metabolomic signatures that contribute to the adverse birthweight outcomes including abnormally high and low birth weight. We also investigated the role of metabolomic signatures in the associations of maternal risk factors such as parity and gestational weight gain with adverse birthweight outcomes. Methods Ninety-six pregnant women and their newborns from the MADRES prospective cohort were studied. Maternal serum at third trimester and newborn cord blood were assayed for untargeted metabolomics using mass-spectrometry. Metabolo

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Bancos, Irina. "Urine steroid metabolomics in adrenal incidentaloma." Endocrine Abstracts, November 2, 2018. http://dx.doi.org/10.1530/endoabs.59.s3.2.

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