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Dissertations / Theses on the topic 'Steroid receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Malouitre, Sylvanie DeÌsireÌe Marie. "Glucocorticoid receptor function, interactions with oestrogen receptors and a steroid inhibitor." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413737.

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2

Brady, P. "A thermodynamic approach to steroid-based receptors." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596861.

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Chapter 1 begins with a brief overview of molecular recognition and then presents a review of recently developed methods for lead generation and the synthesis of self-defining host molecules. Chapter 2 describes a strategy for the synthesis of functionally active molecules which combines advantageous features of some of the methods described in Chapter 1. Relevant literature and precedents are then introduced followed by a discussion of theoretical considerations. In Chapter 3, after an introduction to the use of cholate building blocks in supramolecular chemistry, the synthesis of the new ste

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3

Hazell, Georgina Grace Joan. "Deorphanising G protein-coupled receptors : the search for fast steroid receptors." Thesis, University of Bristol, 2011. http://hdl.handle.net/1983/12fbf473-f360-4831-8123-42698aff4950.

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G protein coupled receptors (GPCRs) are the largest family of transmembrane receptors in the genome and are activated by a multitude of ligands including neuropeptides, hormones and sensory signals. The paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus are important mediators in homeostatic control. Many modulators of PVN/SON activity, including neurotransmitters and hormones act via GPCRs - in fact over 100 non-chemosensory GPCRs have been detected in either the PVN or SON. The introduction to this thesis begins with a comprehensive summary of GPCR expression with

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4

Fischer, Katharina. "The mineralocorticoid receptor amino terminal transactivation domain investigation of structural plasticity and protein-protein interactions /." Thesis, Available from the University of Aberdeen Library & Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24694.

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Thesis (Ph.D.)--Aberdeen University, 2008.<br>Title from web page (viewed on Feb. 23, 2009). With: Natural disordered sequences in the amino terminal domain of nuclear receptors : lessons from the androgen and glucocorticoid receptors / Iain J. McEwan ... et al. Nuclear Receptor Signalling. 2007: 5. Includes bibliographical references.

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5

Nawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.

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A novel bacterial expression system that is capable of producing high levels of soluble, stable, biologically active human vitamin D3 and estrogen receptors has been developed. The method utilizes ubiquitin fusion technology and a low temperature nalidixic acid induction of the lambda PL promoter. This system can produce large quantities of receptor antigen, but only a small fraction displays wild-type DNA and hormone binding properties. Therefore, the use of this system to overproduce receptors for crystallization studies is not practical. To overcome these problems, a 2 um based ubiquitin fu

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6

Smith, Robert A. "The Role of the Steroid Nuclear Receptor Genes in Breast Cancer." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365401.

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Breast cancer is a great source of morbidity and mortality in the developed world, being the most common cause of cancer death in Australian women and affecting roughly 1 in 10 women. The development and progression of cancers is a multi-stage process, involving numerous perturbations to normal cellular functions, especially to those genes which control cellular growth, cellular differentiation and DNA repair. Over time, these alterations combine to change normal cells into cancerous ones that typically no longer respond to normal control stimuli and grow with great rapidity. The nuclear recep

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7

Judd, Luke William. "Cholapods and cholaphanes : steroid based receptors for anion transport." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544424.

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8

Cziko, Paul. "Molecular Physiological Evolution: Steroid Hormone Receptors and Antifreeze Proteins." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/18733.

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For my dissertation research I explored the diversity and functional evolution of steroid hormone receptors (SRs) in animals and the physiological implications of the evolution of antifreeze proteins in Antarctic notothenioid fishes. For the former, I discovered multiple new SRs from the vast and under-sampled swath of animal diversity known as invertebrates. I used the sequences of these and other newly discovered related receptors in combination with genomic data and molecular phylogenetic techniques to revise the understanding of the evolutionary history of this important gene family. Wh

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9

Shatnawi, Aymen Ahmad. "New Mechanisms of Transcriptional Regulation of the Folate Receptor and other genes by steroid Receptors." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1201810595.

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10

Ayling, Alan J. "Steroidal electroneutral receptors for anions : synthesis and evaluation." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367663.

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11

Scheres, Hubertus Maria Elisabeth. "Immunocytochemical and radiochemical determination of steroid receptors in breast cancer." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5469.

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12

Boman, Karin. "Endometrial carcinoma : steroid hormones and receptors in relation to proliferation." Doctoral thesis, Umeå universitet, Onkologi, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100588.

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The significance of the hormonal milieu for endometrial changes is as well-known as its link with endometrial carcinoma. Unopposed oestradiol treatment is shown to increase the incidence for this cancer. Obesity leads to elevated levels of oestrogens and is a risk factor for endometrial carcinoma. An association between high tumour proliferation and prognosis is a general feature of human cancer. Tumour growth can be expressed as proliferation rate and flow cytometry (FCM) is a sensitive and reproducable method to estimate S-phase fraction (SPF) and ploidy level. Both parameters have been show

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13

Clarkson, Alison Marie. "Maternal recognition of pregnancy and steroid receptors in ovine endometrium." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267152.

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14

Riedner, Jens. "Towards a second generation of steroid-derived enantioselective carboxylate receptors." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390650.

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15

Rerra, Anna-Isavella. "Genome-wide analyses of signaling pathways controlled by steroid receptors." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ059.

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Les androgens(ADs) et les glucocorticoïdes (GCs) sont des hormones stéroïdiennes qui exercent des effets pléiotropes chez les mammifères. Leurs effets sont relayés par deux récepteurs nucléaires, le récepteur des androgènes (AR) et le récepteur des glucocorticoïdes (GR), respectivement. Même si les GCs sont fréquemment utilisés pour traiter les maladies inflammatoires et les antiandrogènes pour le cancer de la prostate, les traitements à long terme induisent des effets secondaires majeurs, notamment l'atrophie musculaire.Afin de préciser les mécanismes d’action de ces hormones, nous avons réal

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16

Hazra, Rasmani. "Sertoli cell steroid nuclear receptors in testis development and function." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10504.

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Steroid action is vital for the development and function of male gonads. Androgen and the androgen receptor (AR) are critical for the initiation and maintenance of complete spermatogenesis and male fertility. Despite this fundamental role, the precise AR-regulated pathways controlling spermatogenic development have yet to be resolved. A major focus of this research was to use a unique gain-of-function transgenic (Tg) mouse model to determine the temporal role of Sertoli cell-specific AR expression in testicular development. The Sertoli cell-specific rat Abpa promoter directed human Tg AR [Tg S

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17

Wacker, Douglas W. "Steroid regulation of seasonal territorial aggression in the male song sparrow, Melospiza melodia morphna /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10625.

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18

Cluning, Carmel. "Steroid receptor-associated immunophilins : influence of targeted knockdown and altered expression on receptor signalling." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0215.

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[Truncated abstract] Steroid receptors belong to the superfamily of nuclear receptors, and include the androgen receptor (AR), estrogen receptors (ER[alpha] and ER[beta], glucocorticoid receptor (GR), mineralocorticoid receptor (MR), and the progesterone receptors (PRA and PRB). Before binding ligand, the receptor undergoes biochemical and structural modifications through a series of interactions with molecular chaperones and cochaperones all within a receptor heterocomplex. The mature receptor complexes with the major chaperone Hsp90, the stabilising cochaperone p23, and one member of a group

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19

Dahmoun, Marju. "Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112.

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20

Chen, Junling. "Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/34980.

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Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard. The ERα is phosphorylated at Ser¹¹⁸ in the nucleus and at Ser¹⁶⁷ in both nucleus and cytoplasm after GnRI-I treatments, and this coin

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21

ALLEGRETTO, ELIZABETH ANNE. "STRUCTURE - FUNCTION RELATIONSHIPS OF THE VITAMIN D HORMONE RECEPTOR." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184182.

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Avian intestinal cytosoluble receptors for 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) were subjected to limited trypsin digestion, endogenous proteolytic action, as well as carboxypeptidase treatment, and the physical and functional properties of the resulting discrete polypeptide fragments were identified and contrasted with the native 1,25(OH)₂D₃ receptor. Resultant fragments were followed by tracing either radioactive 1,25(OH)₂D₃ or by probing with anti-receptor monoclonal antibodies. Two differentially trypsin-sensitive effects on the 1,25(OH)₂D₃ receptor were noted when fragments were detecte

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22

MANGELSDORF, DAVID JOHN. "MOLECULAR BIOLOGY AND ACTIONS OF THE VITAMIN-D HORMONE RECEPTOR." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184218.

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The active form of vitamin D is the steroid hormone 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃]. Central to the mechanism of action of 1,25(OH)₂D₃ is its specific, high affinity intracellular receptor. This research focused on the participation of this receptor in the biology, biochemistry, and molecular biology of the vitamin D regulatory system. The effects of 1,25(OH)₂D₃ on the differentiation of hematopoietic cells were investigated using the cultured human promyelocytic leukemia cell line, HL-60, as a model. It was observed that 1,25(OH)₂D₃ induced macrophage differentiation in HL-60 cells and

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23

Hébert-Losier, Andréa 1983. "Structural and functional characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116111.

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Our lab has previously reported the identification of a novel endogenous 19-nor steroid, estradienolone (ED), in pregnant women that strongly bound to sex hormone binding globulin. Estrogen-receptor related receptors (ERRs), which have no known natural ligands, are a family of orphan receptors consisting of 3 isoforms: ERRalpha, ERRbeta and ERRgamma. The ERRs have been shown to actively modulate estrogenic responses, to play an essential role in pregnancy, and are implicated in breast cancer prognosis. My results show that ED acts as an antagonist of the ERRalpha confirming preliminary results

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24

Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

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25

Ildgruben, Anna. "Human vaginal epithelial immunity and influences of hormonal contraceptive usage." Doctoral thesis, Umeå : Klinisk mikrobiologi, enh. för Immunologi och Klin. vetenskap, obstetrik och gynekologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-595.

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26

Trout, Amanda L. "SEX DIFFERENCES IN CELL DEATH AND STEROID HORMONE RECEPTORS IN CORTICAL EXPLANTS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/6.

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Estrogens, such as the biologically active 17-b estradiol (E2) have many actions in the male and female brain. Not only does E2 regulate reproductive behavior in adults, it organizes and activates the brains of younger animals in a sex-specific manner. In addition, many human studies have shown E2 to provide protection against a variety of neurological disorders, including stoke. These studies have been controversial and depend largely on the type and timing of hormone replacement. Animal studies are much less controversial and clearly demonstrate a neuroprotective role for E2 following ischem

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27

Pursell, Natalie W. "Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/535.

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Among heat shock proteins, Hsp90 is unusual because it is not required for the proper folding of most cellular proteins but rather is disproportionally linked to the activation of signal transduction proteins including over forty kinases and many steroid hormone receptors. Mutated forms of many Hsp90 clients are causative agents in cancer, making Hsp90 a promising pharmacological target. Many small molecular inhibitors have been identified that competitively bind to the ATP binding site of Hsp90, some of which are in clinical trials as anticancer agents. Although the activation of kinase and h

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28

陳家文 and Ka-man Chan. "Molecular cloning and characterization of two cDNAs encoding for two forms of FTZ-F1 in the sand shrimp, Metapenaeus ensis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31220381.

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29

McCarrick, Jessica Anne. "Differential Regulation of Steroid Receptors in Breast Cancer by the Rho GEF Vav3." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/124.

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Recently reported data demonstrate that Vav3, a Rho Guanine Nucleotide Exchange Factor (Rho GEF) is overexpressed in breast tumors, coexpressed with ER, necessary for proliferation in breast cancer cells, and predictive of response to neoadjuvant endocrine therapies in patients with ER+ tumors. Such data beg the question as to what roles Vav3 plays in modulation of steroid receptor activity in breast cancer and in resistance to current hormonal therapies. Using reporter assays, I provide novel evidence that Vav3 potentiates Estrogen Receptor activity and represses Androgen Receptor activity in

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30

Maitra, Rajatavo. "Neuroactive steroid modulation of human GABA[subscript]A receptors expressed in Xenopus oocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0006/NQ38316.pdf.

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31

Varshochi, Rana. "Steroid receptors and cell proliferation : cross-talk with the PI3K/Akt signalling pathway." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441958.

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32

Belle, Mino David Charles. "Central expression of sex steroid receptors during the ring dove (Streptopeliarisoria) breeding cycle." Thesis, University of Central Lancashire, 2002. http://clok.uclan.ac.uk/1750/.

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The ring dove (Streptopeliafi sotia) has proved an excellent animal model for studies in reproductive endocrine-behaviour interactions for many years. It shows bi-parental care and has a stereotyped breeding cycle. Androgen receptor and progesterone receptor immunoreactivity (AR-ir and PR-ir) were localised in the brain of male and female ring doves. Nuclear AR-ir in courting birds was widespread throughout the telencephalong diencephalon, and mesencephalon. Nuclear PR-ir was only localised in discrete regions of the preoptic-hypothalamus of both sexes. In the anterior and posterior hypothalam

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33

Brown, Heather L. D. "Steroid hormone receptor regulation of neuronal pruning and outgrowth in the Drosophila central nervous system /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5097.

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34

Szymanski, de Toledo Maria Carolina 1982. "Expressão dos receptores de estrógeno, progesterona, andrógeno e HER2 no câncer epitelial de ovário : Expression of estrogen, progesterone, androgen and HER2 receptors in the epithelial ovarian cancer." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310530.

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Orientadores: Luis Otávio Zanatta Sarian, Sophie Françoise Mauricette Derchain<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-11-07T13:36:45Z (GMT). No. of bitstreams: 1 Toledo_MariaCarolinaSzymanski_M.pdf: 838964 bytes, checksum: 3c546db1a656989db9f433b93287b2d2 (MD5) Previous issue date: 2012<br>Resumo: Introdução: o câncer de ovário é comumente diagnosticado em estágios avançados, sendo atualmente a neoplasia ginecológica de maior letalidade. As pesquisas têm direcionado esforços na tentativa de descobrir no

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35

Humphries, Karin Hartmann. "Steroid hormone receptors and plasminogen activator in human breast cancer : their value in prognosis." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25888.

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Steroid hormone receptor analysis has emerged as an important aid to prognosis in human breast cancer. The availability of ¹²⁵I-labeled estradiol led to the development of a dual-label assay for the simultaneous determination of estrogen and progesterone receptor content. There are indications that plasminogen activator activity may also serve as a prognostic indicator in breast cancer. Two methods, one fluorometric and the other spectrophotometric were examined for their suitability in assaying for plasminogen activator activity. Both assays were found to be equally suitable for the determi

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36

Guo, Wei-Xing. "Regulation of AIDS-related Kaposi's sarcoma cell proliferation by steroid/retinoid and their receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ38804.pdf.

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37

Patki, Mugdha. "Novel Actions of Steroid Receptors that Limit Treatment Response in Breast and Lung Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1382094235.

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38

Flood, Lars. "Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-020-6/.

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39

Englund, Katarina. "Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4706-6/.

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40

Durham, B. H. "A study of the protamine precipitable cytoplasmic female sex-steroid receptors in human endometrial tissue." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373778.

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In Part 1 of the study methods for estimating the concentrations of the total and free specific steroid receptors for oestradiol and progesterone in the cytoplasm from endometrial tissue are assessed and novel features integrated. The cytosol is treated with Dextran coated charcoal (DCC), and after removing the DCC the steroid receptor proteins are precipitated from the cytosol with a protamine sulphate solution prior to incubation of the precipitate with 3H-labelled steroids in a phosphate buffer. Conditions for the optimum binding of the 3H-labelled steroids are investigated. These include t

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41

Benz, David James. "Estrogenic and androgenic regulation of human osteoblast-like cells is mediated by specific steroid receptors." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185442.

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The effectiveness of estrogen replacement therapy in the prevention of postmenopausal osteoporosis has led to its current widespread use throughout the United States and much of Western Europe, and recently, clinical correlations between circulating androgen levels and structural bone integrity have been presented. Nevertheless, the biochemical mechanism through which estrogens and androgens act to protect and maintain bone has remained unclear. One possibility is that these hormones directly modulate the activity of cells responsible for bone formation. Therefore, studies were conducted to ex

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42

Chuffa, Luiz Gustavo de Almeida 1982. "Ação da melatonina sobre os receptores esteróides sexuais no ovário, oviduto e útero e o estresse oxidativo nos ovários de ratas adultas UChB (consumidoras voluntárias de etanol a 10%) durante a ovulação." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317529.

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Orientador: Francisco Eduardo Martinez<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-19T13:39:58Z (GMT). No. of bitstreams: 1 Chuffa_LuizGustavodeAlmeida_D.pdf: 15555306 bytes, checksum: 529d72ca8a05307176cbc131d68adbcd (MD5) Previous issue date: 2011<br>Resumo: O alcoolismo crônico está associado a distúrbios no sistema reprodutor feminino como disfunção hormonal, alteração na expressão dos receptores esteróides, produção de espécies reativas de oxigênio (ERO), entre outros. A melatonina, hormônio secretado pela glândul

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43

Fochi, Ricardo Alexandre 1982. "Influência da progesterona sobre a próstata do gerbilo (Meriones unguiculatus) = interações com o estrógeno e com a testosterona = Progesterone influence on gerbil (Meriones unguiculatus) prostat e: interactions with estrogen and testosterone." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317913.

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Orientador: Sebastião Roberto Taboga<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-22T21:03:05Z (GMT). No. of bitstreams: 1 Fochi_RicardoAlexandre_D.pdf: 82352124 bytes, checksum: 0b04a033b507e3af74ad263a5b3faa8a (MD5) Previous issue date: 2013<br>Resumo: A próstata, glândula do sistema genital que tem origem embrionária a partir do seio urogenital, não é exclusiva do sistema reprodutor masculino, sendo também encontrada em fêmeas de vários mamíferos, incluindo humanos e roedores. No macho ela pode apresentar-se altament

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44

Brito, Claudia Prado de. "Avaliação imunoistoquímica dos receptores de estrógeno e progesterona no tumor venéreo transmissível (TVT) e tecido vaginal de cadelas portadoras e hígidas em diferentes fases do ciclo estral." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-18102004-105856/.

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O tumor venéreo transmissível (TVT) é uma das neoplasias de maior incidência na espécie canina acometendo principalmente o trato genital masculino e feminino. Embora o tratamento de escolha seja a quimioterapia, a resistência às drogas tem sido um fenômeno freqüentemente observado na prática clínica. A determinação dos receptores esteróides (estrógeno e progesterona) por imunoistoquímica em tecidos normais e tumorais de humanos e várias espécies animais, tem mostrado grande importância tanto na avaliação prognóstica da doença tumoral, como também na possibilidade de tratamentos hormonais como

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45

Monaghan, Amy Elizabeth. "The amino terminal domain of steroid hormone receptors as a novel drug target : identification of small molecule inhibitors." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230709.

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Steroid hormone receptors (SHRs) are well validated therapeutic targets in a number of diseases. Current therapies competitively antagonise the ligand binding domain (LBD), blocking activation of the receptor and downstream signalling pathways. However cross-reactivity can be seen amongst the antagonists of different SHRs eliciting unwanted side effects. Additionally the acquisition of resistance to current therapies in diseases such as prostate cancer limits their use. The amino-terminal domain (NTD) of SHRs provides an alternative target for antagonism by allowing potential therapies to bloc

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46

Goold, Richard David. "Influence of endogenous female sex-steroids on mutagen metabolism." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1004919.

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Cytochrome P-450, the terminal oxidase of the metabolic mono-oxygenase system, is thought to exist in multiple forms, which have differing substrate specificities, and are variably inducible by different enzyme inducers. Many mutagens, themselves unreactive, require metabolic activation by one or more of these cytochrome P-450-dependent microsomal enzymes for mutagenic activity. Such mutagens may be detected in the Salmonella mutagenicity test only by the incorporation of an hepatic microsomal (59) fraction into the assay (as a first approximation to in vivo metabolism). Induction of the micro

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47

Auerbach, Scott Sean. "Functional effects of genetic polymorphism and splice variation in human nuclear receptors and their co-activators /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6307.

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Main, Ewan Ralph Gibson. "Studies on the immunosuppressant binding protein FKBP12 and the nuclear/steroid receptors vitamin D3 and oestrogen." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621749.

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To, Kit-wa Anthea, and 杜潔華. "Steriod regulation of growth hormone gene expression and molecular cloning of estrogen receptors in Chinese grass carp." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B2664227X.

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Isaksson, Friman Erika. "Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-182-9/.

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