Log in

Relevant bibliographies by topics / Steroid-resistant nephrotic syndrome / Journal articles

To see the other types of publications on this topic, follow the link: Steroid-resistant nephrotic syndrome.

Journal articles on the topic 'Steroid-resistant nephrotic syndrome'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Steroid-resistant nephrotic syndrome.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Warejko, Jillian K., Weizhen Tan, Ankana Daga, et al. "Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome." Clinical Journal of the American Society of Nephrology 13, no. 1 (2017): 53–62. http://dx.doi.org/10.2215/cjn.04120417.

Full text

Abstract:

Background and objectivesSteroid-resistant nephrotic syndrome overwhelmingly progresses to ESRD. More than 30 monogenic genes have been identified to cause steroid-resistant nephrotic syndrome. We previously detected causative mutations using targeted panel sequencing in 30% of patients with steroid-resistant nephrotic syndrome. Panel sequencing has a number of limitations when compared with whole exome sequencing. We employed whole exome sequencing to detect monogenic causes of steroid-resistant nephrotic syndrome in an international cohort of 300 families.Design, setting, participants, &

APA, Harvard, Vancouver, ISO, and other styles

2

K., Ramya, Balasubramanian M., and Sharon S. "Urinary Interleukin 18 in Children with Nephrotic Syndrome and Its Role in Steroid Responsiveness." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 909–14. https://doi.org/10.5281/zenodo.10968918.

Full text

Abstract:

<strong>Introduction: </strong>Nephrotic syndrome includes the clinical manifestation of glomerular diseases associated with heavy proteinuria i.e., nephrotic range (40 mg/m²/hr or >1000 mg/m²/day; spot Up/Uc>2 mg/mg; 3-4+ by urine dipstick); hypoalbuminemia (albumin <3.0 g/dL); and edema. In children, the most common cause of nephrotic syndrome is idiopathic or primary nephrotic syndrome (INS), also called nephrosis. In the kidney, the predominant source of IL-18 is the tubular epithelial cells. In the recent years, the biological and pathological roles of IL-18 have b

APA, Harvard, Vancouver, ISO, and other styles

3

Burlaka, Ie A., and I. V. Bagdasarova. "Molecular factors predicting steroid resistance in pediatric nephrotic syndrome." Ukrainian Journal of Nephrology and Dialysis, no. 2(70) (March 21, 2021): 32–37. http://dx.doi.org/10.31450/ukrjnd.2(70).2021.04.

Full text

Abstract:

Objectives: the objective of this paper was to study the levels of cellular hypoxia, apoptosis controlling factors in children with steroid-sensitive and steroid-resistant nephrotic syndrome. Background: patients with steroid-resistant nephrotic syndrome (SRNS) represent a challenging subset of patients with nephrotic syndrome who often fail standard immunosuppression and have a higher likelihood of progressing to end-stage renal disease. The search of the biochemical markers undergoing the steroid-resistance is under urgent need. Methods: an examination of kidney biopsies and bloo

APA, Harvard, Vancouver, ISO, and other styles

4

Banerjee, Sushmita. "Steroid resistant nephrotic syndrome." Indian Journal of Pediatrics 69, no. 12 (2002): 1065–69. http://dx.doi.org/10.1007/bf02724390.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Kitamura, Akiko, Hiroyasu Tsukaguchi, Kenichi Maruyama, et al. "Steroid-resistant nephrotic syndrome." Kidney International 74, no. 9 (2008): 1209–15. http://dx.doi.org/10.1038/ki.2008.297.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Quader, Mohammed Maruf Ul. "Familial nephrotic syndrome: Does it matter?" Paediatric Nephrology Journal of Bangladesh 8, no. 2 (2023): 69–77. http://dx.doi.org/10.4103/pnjb.pnjb_15_23.

Full text

Abstract:

Abstract Steroid sensitive nephrotic syndrome (SSNS) is the most common form of nephrotic syndrome in childhood. Familial SSNS seems to be clinically homogeneous but reports on genetically informative SSNS families are lacking. Familial SSNS was found to be genetically distinct from familial steroid resistant nephrotic syndrome (SRNS). Several genes have been identified for SRNS. In general, genetic forms of nephrotic syndrome are resistant to common therapeutic approaches. But different cohort of steroid sensitive familial nephrotic syndrome were published. So precise clinical and genetic inf

APA, Harvard, Vancouver, ISO, and other styles

7

Doku Diamant Shtiza, Ana. "Case Report on Steroid - Resistant Nephrotic Syndrome in Children." International Journal of Science and Research (IJSR) 12, no. 4 (2023): 595–97. http://dx.doi.org/10.21275/sr23331181047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Bunde, Saili Vishwanath, Mumtaz Sharif, and Amit Saxena. "Bacterial meningitis in a known case of steroid-resistant nephrotic syndrome." Indian Journal of Child Health 8, no. 9 (2021): 338–39. http://dx.doi.org/10.32677/ijch.v8i9.3039.

Full text

Abstract:

Nephrotic syndrome (NS) is a kidney disorder in which, excess protein is being excreted through urine. While most cases of idiopathic nephrotic syndrome respond to steroid therapy and experience a limited number of relapses prior to complete remission, some cases suffer from frequent relapses and become steroid-dependent or are primarily steroid-resistant. Treatment options are limited to immunosuppressive drugs with significant side effect profiles. Infections in nephrotic syndrome are common and can be severe. Meningitis is one of the complications associated with nephrotic syndrome. Here, w

APA, Harvard, Vancouver, ISO, and other styles

9

Gaikwad, Dr Sarita Pradip. "Effective Ayurvedic Management of Steroid Resistant Nephrotic Syndrome - Case Study." Journal of Medical Science And clinical Research 11, no. 10 (2023): 25–32. http://dx.doi.org/10.18535/jmscr/v11i10.05.

Full text

Abstract:

Nephrotic syndrome presents with heavy proteinuria (3.5 g Proteins/ 1.73 m2 body surface area/24 hour), dyslipidaemia/ hypercholesterolemia, hypoalbuminema, edema and hypertension. If left untreated or undiagnosed, there is progressive damage to glomeruli causing renal failure. Heavy proteinuria is the most characteristic feature of this syndrome. Several studies have noted that higher the 24-h urine protein excretion, more rapid is the decline in GFR. It may be primary or secondary to other systemic diseases. Case study: This 2 year old male child developed Nephrotic syndrome and was placed o

APA, Harvard, Vancouver, ISO, and other styles

10

ITAMI, NORITOMO, YASUSHI AKUTSU, HLROYUKI TOCHIMARU, YASUO TAKEKOSHI, TOSHIMORI SEKI, and MASAKI TOGASHI. "RECURRENT STEROID-RESISTANT NEPHROTIC SYNDROME." Transplantation 49, no. 1 (1990): 234–35. http://dx.doi.org/10.1097/00007890-199001000-00057.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

McBryde, Kevin D., David B. Kershaw, and William E. Smoyer. "Pediatric steroid-resistant nephrotic syndrome." Current Problems in Pediatrics 31, no. 9 (2001): 280–307. http://dx.doi.org/10.1067/mps.2001.119800.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Qaiser, Habib, Irshad Bajeer, Sabeeta Khatri, Seema Hashmi, and Ali Asghar Lanewala. "A retrospective analysis of clinicopathological features and outcome of secondary steroid resistant nephrotic syndrome." Journal of the Pakistan Medical Association 74, no. 4 (2024): 524–27. http://dx.doi.org/10.47391/jpma.10584.

Full text

Abstract:

Objective: To determine the clinico-pathological features and long-term outcome of secondary steroid-resistant nephrotic syndrome treated with steroids and calcineurin inhibitors. Method: The retrospective cohort study was conducted at the Sindh Institute of Urology and Transplant, Karachi, in June and July 2023, and comprised data from January 1, 2008, to December 31, 2020, of children aged 1-18 years who developed steroid resistance after initial sensitivity to steroids with at least 1-year of follow-up. Demographics as well as time taken to secondary steroid response were documented. Renal

APA, Harvard, Vancouver, ISO, and other styles

13

Турсын, А. Е. "CLINICAL CASE: STEROID-RESISTANT NEPHROTIC SYNDROME." Farmaciâ Kazahstana, no. 5 (December 14, 2021): 13–17. http://dx.doi.org/10.53511/pharmkaz.2021.94.96.003.

Full text

Abstract:

Описан клинический случай пациент с нефротическим синдромом, стероид резистентный вариант, с артериальной гипертензией, осложненный полисерозитом (гидроторакс, асцит, плеврит). Пациент поступил в клинику в состоянии средней степени тяжести, с массивными отеками, полисерозитом, артериальной гипертензией и выраженным нефротическим синдромом. Диагноз: Гломерулярная болезнь. Нефротический синдром, стероид резистентный вариант. Функция почек снижена (СКФ- 84мл/мин по Шварцу). Двухсторонний экссудативный плеврит. Гидроторакс. Полисерозит (в рамках нефротического синдрома) был установлен на основании

APA, Harvard, Vancouver, ISO, and other styles

14

Mbanefo, NR, FN Ogbuka, CA Nwaoha, CL Odimegwu, SN Uwaezuoke, and HU Okafor. "The Pattern of Steroid Sensitivity and Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome: A 5-Year Retrospective Observational Descriptive Study in a South-East Nigerian Tertiary Hospital." Nigerian Journal of Clinical Practice 26, no. 7 (2023): 1017–22. http://dx.doi.org/10.4103/njcp.njcp_1_23.

Full text

Abstract:

ABSTRACT Background/Aim: Nephrotic syndrome is the most common glomerular disease of childhood. Majority of the idiopathic cases frequently respond to steroid therapy and are regarded as steroid-sensitive nephrotic syndrome. Several studies have reported a change in this usual pattern to steroid-resistant nephrotic syndrome in Nigerian children. This study aimed to determine the pattern of steroid sensitivity and steroid resistance in childhood idiopathic nephrotic syndrome seen at a tertiary hospital in Enugu, south-east Nigeria. Materials and Methods: A retrospective study conducted in child

APA, Harvard, Vancouver, ISO, and other styles

15

Akbar, Muhammad, Oke Rina Ramayani, and Gema Nazri Yanni. "Blood Pressure Differences in Nephrotic Syndrome Patients with Steroid Resistant Nephrotic Syndrome Patients and Steroid Sensitive Nephrotic Syndrome." Open Access Macedonian Journal of Medical Sciences 9, T3 (2021): 349–52. http://dx.doi.org/10.3889/oamjms.2021.6315.

Full text

Abstract:

BACKGROUND: Syndrome nephrotic is the most common kidney disease found in pediatric kidney disease, classification based on clinical response to steroids or histopathological characteristics. Increased blood pressure in steroid-resistant nephrotic syndrome (NS) is still a complication to be aware of in cases of NS. AIM: The aim of the study was to determine the differences in systolic and diastolic blood pressure in patients with steroid-sensitive NS and steroid-resistant NS. METHODS: Analytical correctional study in 50 children with NS divided into 25 Steroid Resistant NS (SRNS) groups and 25

APA, Harvard, Vancouver, ISO, and other styles

16

Akbar, Muhammad, Oke Rina Ramayani, and Gema Nazri Yanni. "Blood Pressure Differences in Nephrotic Syndrome Patients with Steroid Resistant Nephrotic Syndrome Patients and Steroid Sensitive Nephrotic Syndrome." Open Access Macedonian Journal of Medical Sciences 9, T3 (2021): 349–52. http://dx.doi.org/10.3889/oamjms.2021.6315.

Full text

Abstract:

BACKGROUND: Syndrome nephrotic is the most common kidney disease found in pediatric kidney disease, classification based on clinical response to steroids or histopathological characteristics. Increased blood pressure in steroid-resistant nephrotic syndrome (NS) is still a complication to be aware of in cases of NS. AIM: The aim of the study was to determine the differences in systolic and diastolic blood pressure in patients with steroid-sensitive NS and steroid-resistant NS. METHODS: Analytical correctional study in 50 children with NS divided into 25 Steroid Resistant NS (SRNS) groups and 25

APA, Harvard, Vancouver, ISO, and other styles

17

Palaniyandi, Anitha, and Subramani Palaniyandi. "Comparison of clinical and lab profile between steroid sensitive and steroid resistant nephrotic syndrome at onset of disease and evaluating predictors for developing steroid resistance in nephrotic syndrome." International Journal of Contemporary Pediatrics 7, no. 6 (2020): 1304. http://dx.doi.org/10.18203/2349-3291.ijcp20202138.

Full text

Abstract:

Background: Nephrotic syndrome is a notable chronic disease in children. The objective of this study was to compare the clinical and lab profile between steroid sensitive nephrotic syndrome and steroid resistant nephrotic syndrome at the onset of disease. Certain parameters were tested if they could be significate predictors of developing steroid resistance at the onset of first episode of nephrotic syndrome.Methods: Retrospective observation study done children 1-12 years diagnosed with nephrotic syndrome in Sri Ramachandra Medical College and Hospital, Department of Paediatrics, Chennai. Sam

APA, Harvard, Vancouver, ISO, and other styles

18

Hasan, Faleeha Obaid, Mohamed Saad Fadhil Al Ubaidy, and Haider Sabri Murad. "outcome of steriod resistant nephrotic syndrome of children in central teaching hospital of pediatrics." Karbala Journal of Medicine 15, no. 1 (2022): 2587–95. http://dx.doi.org/10.70863/karbalajm.v15i1.1011.

Full text

Abstract:

OUTCOME OF IDIOPATHIC STEROID RESISTANT NEPHROTIC SYNDROME OF CHILDREN IN CENTRAL TEACHING HOSPITAL OF PEDIATRICS Abstract Background: Steroid resistant nephrotic syndrome accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. These patients are at risk of developing end stage renal disease. Aim of the study: to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and outcome in pediatric patients with steroid resistant nephrotic syndrome. Materials and Methods: This retrospective study included 136 children patients diagnosed

APA, Harvard, Vancouver, ISO, and other styles

19

Lestari, Nina, Neti Nurani, and Madarina Julia. "Corticosteroids and obesity in steroid-sensitive and steroid-resistant nephrotic syndrome." Paediatrica Indonesiana 55, no. 4 (2015): 194. http://dx.doi.org/10.14238/pi55.4.2015.194-8.

Full text

Abstract:

Background Children with nephrotic syndrome need high-dose corticosteroids to achieve remission. Studies have estimated a 35-43% risk of obesity in these patients after corticosteroid treatment.Objective To determine the prevalence of obesity in children who received corticosteroids for nephrotic syndrome, and to compare the risk of obesity in children with steroid-sensitive nephrotic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS).Methods We performed a retrospective cohort study in 50 children with SSNS or SRNS who received corticosteroid treatment. Obesity was defined to be

APA, Harvard, Vancouver, ISO, and other styles

20

Rehman, Madeeha, Ali Asghar, Afshan Ehsan, Madiha Aziz, Sabeeta Khatri, and Seema Hashmi. "Can Steroid Response in Idiopathic Childhood Nephrotic Syndrome be Predicted? A Single Center Quasi-Experimental Study." Pakistan Armed Forces Medical Journal 72, no. 3 (2022): 980–85. http://dx.doi.org/10.51253/pafmj.v72i3.6346.

Full text

Abstract:

Objective: To predict the role of clinical risk factors and urinary β2-microglobulin levels as a biomarker for steroid-resistant nephrotic syndrome. Study Design: Quasi-experimental study. Place and Duration of Study: Paediatric Nephrology Department, Sindh Institute of Urology and Transplantation, Karachi Pakistan, from Jun 2019 to Nov 2020. Methodology: All children (3 months to 12 years) with either first episode or relapse of the nephrotic syndrome were included. A stored urine sample was used on 100 patients with steroid-sensitive (group-1) and 35 patients with steroid-r

APA, Harvard, Vancouver, ISO, and other styles

21

Pardede, Sudung Oloan, Andini Striratnaputri, and Muzal Kadim. "Selenium level in steroid-resistant and steroid-sensitive nephrotic syndrome." Paediatrica Indonesiana 60, no. 6 (2020): 316–20. http://dx.doi.org/10.14238/pi60.6.2020.316-20.

Full text

Abstract:

Background The mechanisms of pathogenesis of steroid-resistant nephrotic syndrome (SRNS) and steroid-sensitive nephrotic syndrome (SSNS) are not well understood. Antioxidants, such as glutathione peroxidase enzyme (GPx) and its cofactor, selenium, are thought to slow the progress of nephrotic syndrome (NS). Objective To compare selenium levels in SRNS and SSNS pediatric patients. Methods This cross-sectional study was conducted in 51 SRNS and 30 SSNS patients, aged 2 to 18 years, who visited the Pediatric Nephrology Outpatient Clinic at Cipto Mangunkusumo Hospital, Jakarta. Subject

APA, Harvard, Vancouver, ISO, and other styles

22

Nickavar, Azar, Sahar Sadr Moharerpour, and Ehsan Abiry. "Predictive value of platelet indices in children with idiopathic nephrotic syndrome." Immunopathologia Persa 6, no. 1 (2019): e04-e04. http://dx.doi.org/10.15171/ipp.2020.04.

Full text

Abstract:

Introduction: Different biomarkers have been investigated for prognosis of patients with nephrotic syndrome. Qualitative and quantitative changes have been reported in platelets in these patients. Objectives: The aim of this study was to identify platelet abnormalities and their prognostic value of steroid response in children with idiopathic nephrotic syndrome. Patients and Methods: Platelet counts and indices (mean platelet volume [MPV], platelet distribution width [PDW] and platelet larger cell ratio [PLCR]) were evaluated and compared in 122 children with active nephrotic syndrome (64%; st

APA, Harvard, Vancouver, ISO, and other styles

23

Guaragna, Mara Sanches, Anna Cristina G. B. Lutaif, Andréa T. Maciel-Guerra, Vera M. S. Belangero, Gil Guerra-Júnior, and Maricilda P. De Mello. "NPHS2Mutations: A Closer Look to Latin American Countries." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/7518789.

Full text

Abstract:

Nephrotic syndrome is one of the most common kidney pathologies in childhood, being characterized by proteinuria, edema, and hypoalbuminemia. In clinical practice, it is divided into two categories based on the response to steroid therapy: steroid-sensitive and steroid resistant. Inherited impairments of proteins located in the glomerular filtration barrier have been identified as important causes of nephrotic syndrome, with one of these being podocin, coded byNPHS2gene.NPHS2mutations are the most frequent genetic cause of steroid resistant nephrotic syndrome. The aim of this review is to upda

APA, Harvard, Vancouver, ISO, and other styles

24

Ladapo, Taiwo Augustina, Christopher Imokhuede Esezobor, and Foluso Ebun Lesi. "High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria." International Journal of Nephrology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/350640.

Full text

Abstract:

Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including age, response to treatment, and renal histology were analysed. There were 108 children (median age: 5.9 years, peak: 1-2 years), 90.2% of whom had idiopathic nephrotic syndrome. Steroid sensitivity was 8

APA, Harvard, Vancouver, ISO, and other styles

25

Chaki, Agomoni, Farhana Rahman, Jahanara Arju, et al. "Rituximab in steroid resistant nephrotic syndrome." Paediatrica Indonesiana 59, no. 4 (2019): 175–82. http://dx.doi.org/10.14238/pi59.4.2019.175-82.

Full text

Abstract:

Background Nephrotic syndrome (NS) is one of the most common glomerular disease in children, characterized by massive proteinuria, hypoalbuminemia, dyslipidemia and edema. Steroid-resistant nephrotic syndrome (SRNS) and steroid-dependent nephrotic syndrome (SDNS) present challenges in pharmaceutical management. Patient need several immunosuppressant for optimal control, each of which has significant side effect and difficult to get desired results. Rituximab (RTX) is a monoclonal antibody that targets B cells and has been shown to be effective for patients with SRNS and SDNS. Objective T

APA, Harvard, Vancouver, ISO, and other styles

26

Srivastava, R. N., and V. K. Aggarwal. "Steroid Resistant Nephrotic Syndrome in Children." Apollo Medicine 2, no. 3 (2005): 230–33. http://dx.doi.org/10.1016/s0976-0016(11)60262-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Almeida, Margarida P., Helena A. Almeida, and F. Coelho Rosa. "Vincristine in steroid-resistant nephrotic syndrome." Pediatric Nephrology 8, no. 1 (1994): 79–80. http://dx.doi.org/10.1007/bf00868273.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Tasic, Velibor, Zoran Gucev, and Momir Polenakovic. "Steroid Resistant Nephrotic Syndrome-Genetic Consideration." PRILOZI 36, no. 3 (2015): 5–12. http://dx.doi.org/10.1515/prilozi-2015-0073.

Full text

Abstract:

Abstract Nephrotic syndrome is defined as the association of massive proteinuria, hypoalbuminaemia, edema, and hyperlipidemia. It is separated to steroid-sensitive or steroid-resistant (SRNS) forms in respect to the response to intensive steroid therapy. SRNS usually progresses to end-stage renal failure. According to the North American Pediatric Renal Trials and Collaborative Studies SRNS constitutes the second most frequent cause of ESRD in the first two decades of life. Unfortunately, there is no curative treatment for majority of patients. Majority of the SRNS patients have the histologic

APA, Harvard, Vancouver, ISO, and other styles

29

Hodson, Elisabeth M., and Jonathan C. Craig. "Therapies for steroid-resistant nephrotic syndrome." Pediatric Nephrology 23, no. 9 (2008): 1391–94. http://dx.doi.org/10.1007/s00467-008-0792-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Srivastava, R. N., and V. K. Aggarwal. "Steroid Resistant Nephrotic Syndrome in Children." Apollo Medicine 2, no. 3 (2005): 230–33. http://dx.doi.org/10.1177/0976001620050312.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Roy, Ranjit Ranjan, Md Rafiqul Islam, Abdul Matin, et al. "Relationship of Childhood Idiopathic Nephrotic Syndrome with Asthma, Hypertension, Complement C₃, Urinalysis." Bangladesh Journal of Child Health 35, no. 1 (2012): 11–15. http://dx.doi.org/10.3329/bjch.v35i1.10367.

Full text

Abstract:

A prospective observational study of 43 children with idiopathic nephrotic syndrome (INS) were selected randomly out of 480 children admitted with the disease at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2003 to January 2005. Aim of this study was to correlate the difference in frequency of atopic attack, hypertension, complement c3 level and urinalysis in different types of Idiopathic nephrotic syndrome. Result: Among 43 children with idiopathic nephrotic syndrome (INS), 24 children were steroid sensitive nephrotic syndrome (SSNS) and 19 children having stero

APA, Harvard, Vancouver, ISO, and other styles

32

Mason, Anna E., Ethan S. Sen, Agnieszka Bierzynska, et al. "Response to First Course of Intensified Immunosuppression in Genetically Stratified Steroid Resistant Nephrotic Syndrome." Clinical Journal of the American Society of Nephrology 15, no. 7 (2020): 983–94. http://dx.doi.org/10.2215/cjn.13371019.

Full text

Abstract:

Background and objectivesIntensified immunosuppression in steroid-resistant nephrotic syndrome is broadly applied, with disparate outcomes. This review of patients from the United Kingdom National Study of Nephrotic Syndrome cohort aimed to improve disease stratification by determining, in comprehensively genetically screened patients with steroid-resistant nephrotic syndrome, if there is an association between response to initial intensified immunosuppression and disease progression and/or post-transplant recurrence.Design, setting, participants, & measurementsPediatric patients with ster

APA, Harvard, Vancouver, ISO, and other styles

33

Walters, Giles, Faisal A. Choudhury, and Budhima Nanayakkara. "A Case of Nephrotic Syndrome, Showing Evidence of Response to Saquinavir." Case Reports in Nephrology 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/512549.

Full text

Abstract:

The treatment of primary nephrotic syndrome such as minimal change nephropathy, membranous nephropathy, and focal segmental glomerulosclerosis nephropathy remains challenging. Whilst most cases of idiopathic nephrotic syndrome respond to steroid therapy and experience a limited number of relapses prior to complete remission, some cases suffer from frequent relapses and become steroid dependent or are primarily steroid resistant. Treatment options are limited to immunosuppressive drugs with significant side effect profiles. New modalities targeting novel pathways in the pathogenesis of nephroti

APA, Harvard, Vancouver, ISO, and other styles

34

Alaifan, Badr A., Ahmed A. Jamjoom, Raghad I. Jamal Aldeen, et al. "Rituximab efficacy in pediatric patients with refractory nephrotic syndrome." International Journal of Research in Medical Sciences 5, no. 4 (2017): 1312. http://dx.doi.org/10.18203/2320-6012.ijrms20170911.

Full text

Abstract:

Background: Nephrotic syndrome (NS) in children is a disease of glomerular filtration barrier failure, manifesting with severe proteinuria leading to hypoalbuminemia, hypercholesterolemia, and generalized edema. it could be primary or secondary. In primary NS, also known as idiopathic NS, the histological findings of Primary NS include minimal change disease which mainly respond to steroids (steroid sensitive NS), focal segmental glomerulosclerosis which are usually steroid resistant or membranous nephropathy. Rituximab has been shown to be effective for patients with complicated FRNS/SDNS and

APA, Harvard, Vancouver, ISO, and other styles

35

Kodandapani, Yerroju, Ajay Mohan Varahala, and Rajesh Kumar Songa. "Role of urinary nitrites in predicting steroid responsiveness of nephrotic syndrome: a study conducted in tertiary care center." International Journal of Contemporary Pediatrics 7, no. 4 (2020): 918. http://dx.doi.org/10.18203/2349-3291.ijcp20201155.

Full text

Abstract:

Background: Nephrotic Syndrome (NS) is a common chronic disorder, characterized by alterations of selective permeability at the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. Urinary nitrite excretion serves as a useful investigation in differentiating between steroid responsive and steroid resistant nephrotic syndrome. The aim of the study was to assess the relation between urinary nitrite levels and steroid responsiveness in nephrotic syndrome in children.Methods: 76 children were enrolled in the study suffering with nephrotic syndrome of which

APA, Harvard, Vancouver, ISO, and other styles

36

Abidi, Kaoutar, R. Elqadiry, H. Nassih, A. Bourrahouat, and I. Ait Sab. "Nephrotic Syndrome: Epidemiological, Clinical, Paraclinical and Therapeutic Profile." SAS Journal of Medicine 9, no. 03 (2023): 200–203. http://dx.doi.org/10.36347/sasjm.2023.v09i03.009.

Full text

Abstract:

Background: End-stage kidney disease has several causes, including nephrotic syndrome (NS). Steroid- resistant nephrotic syndrome (SRNS) children are a difficult subset of nephrotic syndrome patients who frequently respond poorly to conventional immunosuppression. Objective: The goals of our research are to analyze the different types of nephrotic syndrome, to study the epidemiological, clinical and paraclinical profile, as well as to present the difficulty in managing steroid-resistant nephrotic syndrome. Methods: Our study is a cross-sectional analysis of all patients hospitalized or followe

APA, Harvard, Vancouver, ISO, and other styles

37

Savenkova, N. D., and D. D. Batrakov. "The hereditary nephrotic syndrome in children: features of clinical phenotype and genotype, pathogenesis, renal prognosis of isolated and syndromic forms." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 68, no. 2 (2023): 13–21. http://dx.doi.org/10.21508/1027-4065-2023-68-2-13-21.

Full text

Abstract:

The review of the literature presents the clinical phenotype and genotype pathogenesis, renal prognosis of isolated and extra-renal manifestation form of hereditary nephrotic syndrome in children. The clinical and genetic features of hereditary steroid-sensitive and steroid-resistant nephrotic syndrome in children caused by mutations of genes encoding the main components of the slit diaphragm, glomerular basement membrane, structural and functional proteins of the podocyte are highlighted. Literature data demonstrate an unfavorable renal prognosis in children with hereditary steroid-resistant

APA, Harvard, Vancouver, ISO, and other styles

38

MOROZOV, S. L., T. S. KURSOVA, O. R. PIRUZIEVA, and V. V. DLIN. "Calcineurin inhibitors in the treatment of primary nephrotic syndrome in children." Practical medicine 21, no. 4 (2023): 23–29. http://dx.doi.org/10.32000/2072-1757-2023-4-23-29.

Full text

Abstract:

In pediatric nephrology, idiopathic nephrotic syndrome is the most common glomerular disease. It is now known that about 70% of children with idiopathic nephrotic syndrome develop relapses of the disease, while about 10% of patients are resistant to steroid therapy. In recent decades, calcineurin inhibitors, cyclosporine A and tacrolimus have been used in the treatment of steroid-resistant and steroid-dependent nephrotic syndrome as the first line of immunosuppressive therapy, forming the basis of the treatment of nephrotic syndrome, with more than 70% of patients achieving complete or partial

APA, Harvard, Vancouver, ISO, and other styles

39

Ciuntu, Angela. "The role of cell signaling molecules in the pathogenesis of glomerulonephritis in children." Moldovan Medical Journal 64, no. 2 (2021): 37–41. http://dx.doi.org/10.52418/moldovan-med-j.64-2.21.07.

Full text

Abstract:

Background: Cytokines are functional class of tiny proteins and glycoprotein and fundamentally they are monomers that function as soluble mediators in an autocrine or paracrine manner. Cytokines are produced by a number of cell types, predominantly leukocytes, and their targets implicate both immune and non-immune cells. Material and methods: This study was performed on 75 children with glomerulonephritis (GN), aged from 2 up to 17 years. There were 20 children with steroid-sensitive nephrotic syndrome (SSNS), 15 children with steroid-resistant nephrotic syndrome (SRNS), 20 children with chron

APA, Harvard, Vancouver, ISO, and other styles

40

Handoko, Ayu, Krisni Subandijah, and Ningrum Paramita Sari. "Hubungan Antara Sindrom Nefrotik Resisten Steroid Dengan Gangguan Pertumbuhan Pada Anak." Journal of Issues in Midwifery 8, no. 2 (2024): 56–63. http://dx.doi.org/10.21776/ub.joim.2024.008.02.2.

Full text

Abstract:

Background: The incidence of nephrotic syndrome is increasing and has been reported to be the second most common disease found in pediatric nephrology. Most children with nephrotic syndrome tend to be picky eaters and have poor appetite due to malabsorption due to intestinal edema and abdominal pain, combined with enteropathic protein loss which can further impair nutrition. In addition, corticosteroid treatment in patients with nephrotic syndrome also has an important role in growth disorders in children that can have a long-term effect and reduce their quality of life if not detected and not

APA, Harvard, Vancouver, ISO, and other styles

41

Abeyagunawardena, Asiri Abeyagunawardena S. "Childhood nephrotic syndrome: steroid sensitive, steroid resistant and beyond." Sri Lanka Journal of Child Health 38, no. 4 (2009): 115. http://dx.doi.org/10.4038/sljch.v38i4.1389.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Westhoff, T. H., S. Schmidt, W. Zidek, J. Beige, and M. van der Giet. "Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome." Clinical Nephrology 65, no. 06 (2006): 393–96. http://dx.doi.org/10.5414/cnp65393.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Wasilewska, Anna, Agnieszka Rybi-Szuminska, and Pawel Dubiela. "Steroid-Resistant Nephrotic Syndrome Caused by NUP93 Pathogenic Variants." Journal of Clinical Medicine 12, no. 18 (2023): 5810. http://dx.doi.org/10.3390/jcm12185810.

Full text

Abstract:

Background: Although steroid therapy is a standard of care for nephrotic syndrome treatment, 15–20% of patients do not respond to it. Finding the genetic background is possible in >10% of steroid-resistant nephrotic syndrome (SRNS) cases. Variants in genes encoding nuclear pore complex proteins are a novel cause of paediatric steroid-resistant nephrotic syndrome (SRNS). Recent studies suggest NUP93 variants to be a significant cause of paediatric onset SRNS. The clinical data on certain variants and disease history are still very limited. Methods and results: We report the SRNS case of a 12

APA, Harvard, Vancouver, ISO, and other styles

44

Mohammed, Rawan Azad, Ahmed Salih Sahib, and Qahtan Mohammed Ali. "Study of genetic polymorphisms of adenosine triphosphate-binding cassette B1 (ABCB1) gene in Iraqi nephrotic syndrome patients on prednisolone therapy." Journal of Nephropathology 14 (March 8, 2025): e27597. https://doi.org/10.34172/jnp.2025.27597.

Full text

Abstract:

Introduction: Steroids are the primary treatment for idiopathic nephrotic syndrome. Pharmacogenomic factors, including genetic and histological modifications, play a significant role in influencing the response to steroids. One such factor is the excessive synthesis of P-glycoprotein (permeability glycoprotein) and multidrug resistance-associated protein 1 (MDR-1), which may contribute to the development of steroid resistance and alterations in steroid pharmacokinetics. Objectives: We examined the correlation between steroid responsiveness and the MDR-1 gene variations, specifically rs1045642

APA, Harvard, Vancouver, ISO, and other styles

45

Park, Eujin. "Genetic Basis of Steroid Resistant Nephrotic Syndrome." Childhood Kidney Diseases 23, no. 2 (2019): 86–92. http://dx.doi.org/10.3339/jkspn.2019.23.2.86.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Gruskin, A. B. "Enalapril Effective in Steroid-Resistant Nephrotic Syndrome." AAP Grand Rounds 5, no. 1 (2001): 6. http://dx.doi.org/10.1542/gr.5-1-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Bagga, Arvind, and Aditi Sinha. "Individualizing Treatment of Steroid-Resistant Nephrotic Syndrome." Clinical Journal of the American Society of Nephrology 15, no. 7 (2020): 920–22. http://dx.doi.org/10.2215/cjn.08080520.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Gubler, Marie Claire. "Genetic testing in steroid-resistant nephrotic syndrome." Nature Reviews Nephrology 7, no. 8 (2011): 430–31. http://dx.doi.org/10.1038/nrneph.2011.75.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Mak, Robert H., and William E. Smoyer. "Genetic screening in steroid-resistant nephrotic syndrome." Nature Reviews Nephrology 9, no. 7 (2013): 379–81. http://dx.doi.org/10.1038/nrneph.2013.101.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Niaudet, Patrick. "Steroid-Resistant Idiopathic Nephrotic Syndrome and Ciclosporin." Nephron 57, no. 4 (1991): 481. http://dx.doi.org/10.1159/000186354.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!