Relevant bibliographies by topics / Sterol 14α-demethylase

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Academic literature on the topic 'Sterol 14α-demethylase'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Sterol 14α-demethylase"

1

Munayyer, Hanan K., Paul A. Mann, Andrew S. Chau та ін. "Posaconazole Is a Potent Inhibitor of Sterol 14α-Demethylation in Yeasts and Molds". Antimicrobial Agents and Chemotherapy 48, № 10 (2004): 3690–96. http://dx.doi.org/10.1128/aac.48.10.3690-3696.2004.

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ABSTRACT Posaconazole (POS; SCH 56592) is a novel triazole that is active against a wide variety of fungi, including fluconazole-resistant Candida albicans isolates and fungi that are inherently less susceptible to approved azoles, such as Candida glabrata. In this study, we compared the effects of POS, itraconazole (ITZ), fluconazole (FLZ), and voriconazole (VOR) on sterol biosynthesis in strains of C. albicans (both azole-sensitive and azole-resistant strains), C. glabrata, Aspergillus fumigatus, and Aspergillus flavus. Following exposure to azoles, nonsaponifiable sterols were extracted and
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Orozco, Alison S., Lindsey M. Higginbotham, Christopher A. Hitchcock, et al. "Mechanism of Fluconazole Resistance inCandida krusei." Antimicrobial Agents and Chemotherapy 42, no. 10 (1998): 2645–49. http://dx.doi.org/10.1128/aac.42.10.2645.

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ABSTRACT The mechanisms of fluconazole resistance in three clinical isolates of Candida krusei were investigated. Analysis of sterols of organisms grown in the absence and presence of fluconazole demonstrated that the predominant sterol of C. krusei is ergosterol and that fluconazole inhibits 14α-demethylase in this organism. The 14α-demethylase activity in cell extracts of C. kruseiwas 16- to 46-fold more resistant to inhibition by fluconazole than was 14α-demethylase activity in cell extracts of two fluconazole-susceptible strains of Candida albicans. Comparing the carbon monoxide difference
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Lepesheva, G. I., T. Y. Hargrove, R. D. Ott, W. D. Nes, and M. R. Waterman. "Biodiversity of CYP51 in trypanosomes." Biochemical Society Transactions 34, no. 6 (2006): 1161–64. http://dx.doi.org/10.1042/bst0341161.

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Sterol 14α-demethylases (CYP51) are metabolic cytochromes P450, found in each biological kingdom. They catalyse a single three-step reaction included in all sterol biosynthetic pathways. Plant CYP51s have strict preference towards their physiological substrate O (obtusifoliol), which is C-4-monomethylated. Natural substrates of animal/fungal CYP51 (lanosterol, 24,25-dihydrolanosterol or 24-methylenelanosterol) are C-4-dimethylated. CYP51 from the pathogenic protozoa TB (Trypanosoma brucei) is the first example of O-specific sterol 14α-demethylase in non-photosynthetic organisms. Surprisingly,
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Ibrahim, Mohammed Auwal, Murtala Bindawa Isah, Nasir Tajuddeen, Saadatu Auwal Hamza та Aminu Mohammed. "Interaction of Stigmasterol with Trypanosomal Uridylyl Transferase, Farnesyl Diphosphate Synthase and Sterol 14α-demethylase: An In Silico Prediction of Mechanism of Action". Letters in Drug Design & Discovery 16, № 7 (2019): 799–807. http://dx.doi.org/10.2174/1570180815666180711110324.

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Background: Trypanosomiasis is one of the neglected tropical diseases and continues to cause serious morbidity, mortality and economic loss. Current anti-trypanosomal drugs are antiquated and suffer from a number of serious setbacks, thereby necessitating the search for new drugs. Stigmasterol has previously demonstrated in vitro and in vivo anti-trypanosomal activity. Methods: Herein, stigmasterol was docked into three validated anti-trypanosomal drug targets; uridylyl transferase, farnesyl diphosphate synthase and sterol 14α-demethylase, in order to elucidate the possible biochemical targets
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5

Hull, Claire M., Josie E. Parker, Oliver Bader, et al. "Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation inERG11and Exhibiting Cross-Resistance to Azoles and Amphotericin B." Antimicrobial Agents and Chemotherapy 56, no. 8 (2012): 4223–32. http://dx.doi.org/10.1128/aac.06253-11.

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ABSTRACTWe identified a clinical isolate ofCandida glabrata(CG156) exhibiting flocculent growth and cross-resistance to fluconazole (FLC), voriconazole (VRC), and amphotericin B (AMB), with MICs of >256, >256, and 32 μg ml−1, respectively. Sterol analysis using gas chromatography-mass spectrometry (GC-MS) revealed that CG156 was a sterol 14α-demethylase (Erg11p) mutant, wherein 14α-methylated intermediates (lanosterol was >80% of the total) were the only detectable sterols.ERG11sequencing indicated that CG156 harbored a single-amino-acid substitution (G315D) which nullified the functi
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6

Lamb, David C., Michel Cannieux, Andrew G. S. Warrilow та ін. "Plant Sterol 14α-Demethylase Affinity for Azole Fungicides". Biochemical and Biophysical Research Communications 284, № 3 (2001): 845–49. http://dx.doi.org/10.1006/bbrc.2001.5010.

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7

Yu, Jin Hui, Ting Qi, Li Xiong, et al. "Fungicides Inhibition Analysis by Molecular Docking and Sensitivity Testing of Penicillium italicum." Applied Mechanics and Materials 380-384 (August 2013): 4170–74. http://dx.doi.org/10.4028/www.scientific.net/amm.380-384.4170.

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Blue mold, caused by Penicillium. italicum, is one of the most damaging postharvest diseases of citrus fruit. P. italicum Sterol 14α-demethylase (PiCYP51), an important enzyme in membrance sterol biosynthesis, is a key target of antifungal compounds for citrus disease caused by P. italicum. The three-dimensional structure of PiCYP51 from P. italicum Chinese isolate (HS-1) was constructed through homology modeling basing on the crystal structure of human CYP51. After molecular dynamics (MD) simulation, the refined model was assessed by PROCHECK on the quality. Following evaluation on the reliab
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8

Franz, Renate, Steven L. Kelly, David C. Lamb, Diane E. Kelly, Markus Ruhnke, and Joachim Morschhäuser. "Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains." Antimicrobial Agents and Chemotherapy 42, no. 12 (1998): 3065–72. http://dx.doi.org/10.1128/aac.42.12.3065.

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ABSTRACT From each of two AIDS patients with oropharyngeal candidiasis, fiveCandida albicans isolates from recurrent episodes of infection which became gradually resistant against fluconazole during antimycotic treatment were analyzed for molecular changes responsible for drug resistance. In both patients, a single C. albicans strain was responsible for the recurrent infections, but the CARE-2 fingerprint pattern of the isolates exhibited minor genetic alterations, indicating that microevolution of the strains took place during fluconazole therapy. In the isolates from patient 1, enhanced mRNA
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9

Warfield, Jasmine, William N. Setzer та Ifedayo Ogungbe. "Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens". SpringerPlus 3, № 1 (2014): 679. http://dx.doi.org/10.1186/2193-1801-3-679.

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10

Sen, Kakali, та John C. Hackett. "Peroxo−Iron Mediated Deformylation in Sterol 14α-Demethylase Catalysis". Journal of the American Chemical Society 132, № 30 (2010): 10293–305. http://dx.doi.org/10.1021/ja906192b.

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Book chapters on the topic "Sterol 14α-demethylase"

1

Kelly, S. L., M. A. Quail, J. Rowe, and D. E. Kelly. "Sterol 14α-Demethylase: Target of the Azole Antifungal Agents." In New Approaches for Antifungal Drugs. Birkhäuser Boston, 1992. http://dx.doi.org/10.1007/978-1-4899-6729-9_9.

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2

Taton, Maryse, Florence Salmon, and Alain Rahier. "Plant Sterol Biosynthesis. Cytochrome P-450 Obtusifoliol 14α-Methyl Demethylase a Key Enzymatic Step." In Plant Lipid Metabolism. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-015-8394-7_93.

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3

Lepesheva, Galina I., Fernando Villalta, and Michael R. Waterman. "Targeting Trypanosoma cruzi Sterol 14α-Demethylase (CYP51)." In Advances in Parasitology. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-385863-4.00004-6.

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