Relevant bibliographies by topics / Sterol O-Acyltransferase – metabolism

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Academic literature on the topic 'Sterol O-Acyltransferase – metabolism'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Sterol O-Acyltransferase – metabolism"

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Hai, Qimin, and Jonathan D. Smith. "Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era." Metabolites 11, no. 8 (2021): 543. http://dx.doi.org/10.3390/metabo11080543.

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The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest in cholesterol metabolism given their profound effects on foam cell biology and intestinal lipid absorption. The generation of mouse models deficient in Soat1 or Soat2 confirmed the importance of their gene products on cholesterol esterification and lipoprotein physiology. Although these studies supported clinical trials which used non-selective ACAT inhibitors, these trials did not report benefits, and one showed an incr
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Ferreira, Célia, and Cândida Lucas. "The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly." Biochimica et Biophysica Acta (BBA) - Biomembranes 1778, no. 11 (2008): 2648–53. http://dx.doi.org/10.1016/j.bbamem.2008.08.011.

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Ferraz-de-Souza, Bruno, Rebecca E. Hudson-Davies, Lin Lin, et al. "Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal." Molecular Endocrinology 25, no. 2 (2011): 374. http://dx.doi.org/10.1210/mend.25.2.zmg374.

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Abstract Context: Steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) is a master regulator of adrenal development and steroidogenesis. Defects in several known targets of SF-1 can cause adrenal disorders in humans. Objective: We aimed to identify novel targets of SF-1 in the human adrenal. These factors could be important regulators of adrenal development and steroidogenesis and potential candidates for adrenal dysfunction. Design: A gene discovery strategy was developed based on bidirectional manipulation of SF-1. Overexpression or knockdown of SF-1 in NCI-H295R human adrenocortical cells was used t
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Petrov, Alexey M., Artem A. Astafev, Natalia Mast, Aicha Saadane, Nicole El-Darzi, and Irina A. Pikuleva. "The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina." Biomolecules 9, no. 12 (2019): 867. http://dx.doi.org/10.3390/biom9120867.

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In mammalian retina, cholesterol excess is mainly metabolized to oxysterols by cytochromes P450 27A1 (CYP27A1) and 46A1 (CYP46A1) or removed on lipoprotein particles containing apolipoprotein E (APOE). In contrast, esterification by sterol-O-acyltransferase 1 (SOAT) plays only a minor role in this process. Accordingly, retinal cholesterol levels are unchanged in Soat1−/− mice but are increased in Cyp27a1−/−Cyp46a1−/− and Apoe−/− mice. Herein, we characterized Cyp27a1−/−Cyp46a1−/−Soat1−/− and Cyp27a1−/−Cyp46a1−/−Apoe−/− mice. In the former, retinal cholesterol levels, anatomical gross structure
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Graugnard, Daniel E., Larry L. Berger, Dan B. Faulkner, and Juan J. Loor. "High-starch diets induce precocious adipogenic gene network up-regulation in longissimus lumborum of early-weaned Angus cattle." British Journal of Nutrition 103, no. 7 (2009): 953–63. http://dx.doi.org/10.1017/s0007114509992789.

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Adipocyte differentiation is probably controlled by transcriptional and post-transcriptional regulation. Longissimus lumborum from Angus steers (aged 155 d; seven animals per diet) fed high-starch or low-starch diets for 112 d (growing phase) followed by a common high-starch diet for an additional 112 d (finishing phase) was biopsied at 0, 56, 112 and 224 d for transcript profiling via quantitative PCR of twenty genes associated with adipogenesis and energy metabolism. At 56 d steers fed high starch had greater expression of PPARγ as well as the lipogenic enzymes ATP citrate lyase (ACLY), gluc
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Kim, Sora, and Kee-Hong Kim. "Modulation of Cholesterol Metabolism Improves Response to Enzalutamide Treatment in Prostate Cancer." Current Developments in Nutrition 5, Supplement_2 (2021): 269. http://dx.doi.org/10.1093/cdn/nzab036_011.

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Abstract Objectives Prostate cancer (PCa) growth is mediated by androgens via activation of androgen receptor (AR). Accordingly, androgen deprivation therapy (ADT) is the gold standard for the treatment of advanced PCa, but progression to castration-resistant PCa (CRPC) follows. Enzalutamide (ENZ) is an AR antagonist used for the management of CRPC. However, patients acquire resistance to the drug in a short period. As cholesterol metabolism is dysregulated in PCa and lipogenesis is upregulated by AR signaling, we hypothesized that inhibition of cholesteryl ester formation and suppression of l
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Jain, Mohit, Soeun Ngoy, Sunil A. Sheth, et al. "A systematic survey of lipids across mouse tissues." American Journal of Physiology-Endocrinology and Metabolism 306, no. 8 (2014): E854—E868. http://dx.doi.org/10.1152/ajpendo.00371.2013.

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Lipids are a diverse collection of macromolecules essential for normal physiology, but the tissue distribution and function for many individual lipid species remain unclear. Here, we report a mass spectrometry survey of lipid abundance across 18 mouse tissues, detecting ∼1,000 mass spectrometry features, of which we identify 179 lipids from the glycerolipids, glycerophospholipids, lysophospholipids, acylcarnitines, sphingolipids, and cholesteryl ester classes. Our data reveal tissue-specific organization of lipids and can be used to generate testable hypotheses. For example, our data indicate
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Oni, Tobiloba E., Giulia Biffi, Lindsey A. Baker, et al. "SOAT1 promotes mevalonate pathway dependency in pancreatic cancer." Journal of Experimental Medicine 217, no. 9 (2020). http://dx.doi.org/10.1084/jem.20192389.

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Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC. However, the changes in cholesterol metabolism and their role during PDAC progression remain largely unknown. Here we used organoid and mouse models to determine the drivers of altered cholesterol metabolism in PDAC and the consequences of its disruption on tumor progression. We identified sterol O-acyltransferase 1 (SOAT1) as a key player in sustaining the mevalonate pathway by converting cho
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Huang, Bang-Lian, Xuan Li, Pei Liu, et al. "Transcriptomic analysis of Eruca vesicaria subs. sativa lines with contrasting tolerance to polyethylene glycol-simulated drought stress." BMC Plant Biology 19, no. 1 (2019). http://dx.doi.org/10.1186/s12870-019-1997-2.

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Abstract Background Eruca vesicaria subsp. sativa is one of the Cruciferae species most tolerant to drought stress. In our previous study some extremely drought-tolerant/sensitive Eruca lines were obtained. However little is known about the mechanism for drought tolerance in Eruca. Methods In this study two E. vesicaria subs. sativa lines with contrasting drought tolerance were treated with liquid MS/PEG solution. Total RNA was isolated from 7-day old whole seedlings and then applied to Illumina sequencing platform for high-throughput transcriptional sequencing. Results KEGG pathway analysis i
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Solé, Emma, Roger Ros-Freixedes, Marc Tor, Ramona N. Pena, and Joan Estany. "A sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-94235-z.

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AbstractThe bulk of body fat in mammals is in the form of triacylglycerol. Diacylglycerol O-acyltransferase 2 (DGAT2) catalyses the terminal step in triacylglycerol synthesis. The proximity of DGAT2 with stearoyl-CoA desaturase (SCD) in the endoplasmic reticulum may facilitate provision of de novo SCD-mediated fatty acids as substrate for DGAT2. Here, we first searched for sequence variants in the DGAT2 gene to then validate their effect on fat content and fatty acid composition in muscle, subcutaneous fat and liver of 1129 Duroc pigs. A single nucleotide polymorphism in exon 9 (ss7315407085 G
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Dissertations / Theses on the topic "Sterol O-Acyltransferase – metabolism"

1

Little, Marie-Térèse E. "The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29416.

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Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol metabolism can be manipulated in early life. Therefore, studies of the developmental patterns of the key enzymes in cholesterol metabolism are of great importance. Acyl coenzyme A: cholesterol acyltransferase (ACAT) is the primary enzyme which catalyzes the conversion of free cholesterol to choleste
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