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Dissertations / Theses on the topic 'STEROPES'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Escoffier, Bernard. "Biotransformation de sterols et steroides par mycobacterium aurum : mise en evidence d'une nouvelle activite metabolique d'hydrolyse d'epoxydes portes par un steroide." Toulouse 3, 1987. http://www.theses.fr/1987TOU30149.

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2

Confavreux, Cyrille. "Physiologie intégrative du métabolisme énergétique, de l’os et de la fertilité : rôle de l’ostéocalcine et des hormones sexuelles." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10039/document.

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L'arrivée des souris transgéniques a ouvert une ère nouvelle pour la physiologie intégrative permettant d’étudier la fonction d'un gène au sein d'un organisme vivant. Ces techniques ont permis la découverte du rôle de l'os sur le métabolisme énergétique et la fertilité. Contrôle neurologique de la masse osseuse. La leptine agit dans le tronc cérébral en freinant les neurones sérotoninergiques qui projettent sur l'hypothalamus pour contrôler la masse osseuse (VMH) et l'appétit (noyau arqué). La sérotonine cérébrale freine le tonus sympathique et stimule la masse osseuse. Régulation osseuse du m

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3

Mühlebach, Anneke. "Sterole im herbstlichen Weddellmeer (Antarktis) : großräumige Verteilung, Vorkommen und Umsatz = Sterols in the autumnal Weddell Sea (Antarctica): large-scale distribution, occurrence, and turnover /." Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung, 1999. http://www.gbv.de/dms/bs/toc/265838851.pdf.

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4

Hanke, Georg. "Vorkommen, Verteilung und Umsatz biogener organischer Spurenstoffe : Sterole in antarktischen Gewässern = Occurrence, distribution and turnover of biogenic organic trace compounds : Sterols in antarctic waters /." Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung, 1995. http://www.gbv.de/dms/goettingen/185783406.pdf.

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5

Lichtfouse, Eric. "Nouveaux steroides aromatiques fossiles." Strasbourg 1, 1989. https://tel.archives-ouvertes.fr/tel-00173767.

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La synthese de steroides triaromatiques methyles en position 2(c#2#1), 3(c#2#1, c#2#7, c#2#9) ou 6(c#2#1) a ete effectuee en plusieurs etapes a partir de la pregnenolone, du cholesterol ou du stigmasterol; leurs structures ont ete confirmees par des experiences en rmn-#1h a 200 mhz (decouplage, noe). Les steroides triaromatiques methyles en position 2, 3 ou 6 ont ete identifies dans les roches et les petroles du bassin de paris par comparaison de leurs donnees chromatographiques (cg) et spectrales (sm) avec les substances de synthese. Leur formation est vraisemblablement due pour les composes

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6

Klötz, Fia. "Anabolic Androgenic Steroids and Criminality." Doctoral thesis, Uppsala University, Forensic Medicine, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8508.

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<p>Anabolic Androgenic Steroids (AAS) have been associated with adverse psychiatric effects, aggression and violent behaviour. The use of them has spread to a larger subpopulation, and the use has been connected to different risk behaviours, such as use of other illicit substances and carrying a gun. Case reports tell about a connection between AAS use and violent crimes, including homicide. The aim of this thesis is to investigate the proposed connection between AAS and crime, focusing on violent crimes, and to inquire into whether this proposed connection between AAS and criminality is affec

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7

Birzniece, Vita. "Neuroactive steroids and rat CNS." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296.

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8

Cobice, Diego Federico. "Mass spectrometry imaging of steroids." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21032.

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Glucocorticoids are steroid hormones involved in the stress response, with a well-established role in promoting cardiovascular risk factors including obesity and diabetes. The focus of glucocorticoid research has shifted from understanding control of blood levels, to understanding the factors that control tissue steroid concentrations available for receptor activation; it is disruption of these tissue-specific factors that has emerged as underpinning pathophysiological mechanisms in cardiovascular risk, and revealed potential therapeutic targets. However, the field is hampered by the inability

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9

PORT, MARC. "Synthese de 19-nor-steroides." Paris 6, 1995. http://www.theses.fr/1995PA066437.

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Ce travail decrit une nouvelle strategie d'obtention de 19-nor-steroides, strategie illustree par une nouvelle synthese totale et chirale de l'acetate de trenbolone et une approche au ru 486. Une reaction intromoleculaire de diels alder d'orthoquinodimethane permet d'obtenir avec de bons rendements des synthons tricycliques a jonction de cycle c/d trans precurseurs de 19-nor-steroides. Les orthoquinodimethanes sont obtenus par elimination 1-4 a partir de benzylsilanes fonctionnalises comportant un groupe partant simple (acetate ou benzoate). Cette methode tres douce de generation des orthoquin

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10

Low, Susan C. "Tissue-specific regulation of 11β-hydroxysteroid dehydrogenase by adrenal steroids, sex steroids and growth hormone". Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19939.

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I have found that 11β-OHSD activity and mRNA expression are regulated by glucocorticoids, but not mineralocorticoids, in rat hippocampus and liver, but not kidney. Hippocampal 11β-OHSD activity and mRNA expression are elevated by dexamethasone and stress suggesting a role for 11β-OHSD in modulating glucocorticoid access to neuronal MR. In agreement with this hypothesis, development of a double in-situ hybridisation technique demonstrated cellular co-localisation of 11β-OHSD mRNA with MR and GR mRNAs in rat hippocampus. I have also demonstrated that 11β-OHSD activity exhibits a sexually-dimorph

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11

Russell, Adam Hamilton. "Nurturing nature : men, steroids and anthropology." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416851.

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12

Boynton, Juliette Alice. "The synthesis of biologically active steroids." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239715.

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13

Kiran, Ismail. "The synthesis of biologically active steroids." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297951.

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14

Haywood, S. A. "GnRH network : noradrenaline and sex steroids." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603906.

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The first studies in this thesis use <I>in situ</I> hybridisation to investigate if temporal changes occur in cellular GnRH gene expression during the preovulatory phase of the oestrous cycle and further investigation gene expression in other neurotransmitter systems in the GnRH network within the preoptic area and the brainstem. It is evident from these studies that, during the oestrous cycle, transcriptional changes within GnRH, enkphalin, nitric oxide synthase and noradrenaline containing neural populations, in the preoptic area and brainstem respectively, are small, and are perhaps not per

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15

Gill, H. K. "The biosynthesis of novel plant steroids." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371123.

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16

Walter, Affo. "A radical-mediated approach to steroids." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289453.

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17

Thomas, Charles Abidemi Adewale. "Synthetic approaches to anti-hormonal steroids." Thesis, City University London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316056.

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18

TEMMEM, OLIVIER. "Nouvelles voies d'acces aux composes steroides." Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13182.

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Dans le cadre d'une synthese totale de composes steroides a proprietes phytohormonales (les brassinosteroides), une nouvelle voie d'acces du systeme a-b-c-d de 6-ceto steroide a ete exploree. Apres avoir montre que le rearrangement d'esters du nerol avec, notamment, l'acide isovalerique ou son derive -hydroxyle (de configuration s), pourrait etre utilise pour generer, de facon rapide, les centres stereogeniques c 1 3 et c 1 7 des molecules cibles avec les configurations relatives desirees, et meme dans le deuxieme cas, absolues, nous avons mis au point une methode de cyanation regio et stereos

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19

Ayerman, Farah. "A synthetic approach to antiprogestational steroids." Thesis, City, University of London, 1996. http://openaccess.city.ac.uk/20855/.

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The nature and uses of some steroidal hormones and anti-hormones are reviewed, with an emphasis on the anti-progestins which have anti-implantation activity. A new type of steroid structure has been designed which combines two types of structural elements, namely an A-nor skeleton and an 11-aryl substituent, which are separately known to display anti-implantation properties. It is demonstrated that a thallium-mediated ring contraction of steroidal 4-en-3-ones carrying an 11-keto group provides entry to a functionalised A-nor steroid skeleton which can then be arylated using organolithium reage

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20

Bijoy, P. "Synthetic Investigations In Terpenoids And Steroids." Thesis, Indian Institute of Science, 1994. https://etd.iisc.ac.in/handle/2005/163.

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The thesis entitled "SYNTHETIC INVESTIGATIONS IN TERPENOIDS AND STEROIDS" consists of 3 Chapters Chapter-I deals with the synthetic studies on the hexacyclic nortriterpene Pfaffic acid 1, and is divided into two sections. Section-I begins with a brief introduction to Pfaffic acid 1, a naturally occurring hexacyclic nortriterpene, in particular to its isolation, structural elucidation and antitumor activity. The antitumor activities of the Pfafosides A, B, C, D, E and F, the glycosides of pfaffic acid 1, isolated from the same plant is also described. The discussion presents the synthetic

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21

Bijoy, P. "Synthetic Investigations In Terpenoids And Steroids." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/163.

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The thesis entitled "SYNTHETIC INVESTIGATIONS IN TERPENOIDS AND STEROIDS" consists of 3 Chapters Chapter-I deals with the synthetic studies on the hexacyclic nortriterpene Pfaffic acid 1, and is divided into two sections. Section-I begins with a brief introduction to Pfaffic acid 1, a naturally occurring hexacyclic nortriterpene, in particular to its isolation, structural elucidation and antitumor activity. The antitumor activities of the Pfafosides A, B, C, D, E and F, the glycosides of pfaffic acid 1, isolated from the same plant is also described. The discussion presents the synthetic str

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22

GARNIER, SERGE. "Pathologie iatrogene des fonctions steroides : etude des effets des therapeutiques chimiques non steroidiennes sur les fonctions steroides." Lyon 1, 1989. http://www.theses.fr/1989LYO1M258.

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23

Cazorla, Saravia Patrick Sebastian, and Elías Reneé Pereyra. "Is it the creatine or the anabolic androgenic steroids? Need for assessing the steroids role in testicular cancer." Cancer Research, 2015. http://hdl.handle.net/10757/575993.

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24

Sadiq, Rizwana. "Enzymatic reactions and coordination complexes of steroids." Thesis, University of Huddersfield, 2015. http://eprints.hud.ac.uk/id/eprint/26195/.

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Research in this thesis investigates a simple, rapid, reproducible and specific liquid chromatography-mass spectroscopy (LC-MS) method for the simultaneous detection, confirmation and quantitation of beclomethasone dipropionate (BDP) and its metabolites beclomethasone monopropionate (BMP) and beclomethasone (BOH) which has been developed and validated. The method was validated over a concentration range from 0.001-100 mg/L for BDP and 0.01-10 mg/L for BOH. The calibration graphs exhibited excellent linearity with typical R2 values for BDP of 0.997 and for BOH of 0.999. The analytes stability w

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25

Dmitrovic, Jasna. "Metabolism of anabolic steroids in cynomolgus monkey." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0008/MQ34956.pdf.

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26

Turner, Simon. "Preoperative steroids and post operative renal dysfunction." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521536.

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27

Wild, Martin James. "Target organ metabolism of oral contraceptive steroids." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317327.

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28

Fairs, Nicola Jane. "Steroids and ovarian development in decapod crustacea." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277210.

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29

Chuah, S. Y. "Prostaglandins and steroids in human mammary cancer." Thesis, University of Strathclyde, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303867.

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30

Hunter, Alan Christy. "The biotransformation of steroids by Cephalosporium aphidicola." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360523.

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31

Yildirim, Kudret. "The biotransformation and synthesis of some steroids." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340848.

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32

Armstrong, Stewart Robert. "Dip strip immunoassays for airborne oestrogenic steroids." Thesis, University of Sunderland, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420741.

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33

Connolly, Fiona. "Reproductive and metabolic programming by exogenous steroids." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17606.

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Polycystic ovary syndrome (PCOS) is a heterogeneous disorder encompassing reproductive and metabolic phenotypes. Genetic analysis, targeting candidate genes has to date proven unsuccessful in the search for a truly dominant genetic link. Another hypothesis to explain the etiology of PCOS is that of fetal programming in the context of developmental origins of health and disease. Extensive animal studies, validated by human data, support the fetal origins hypothesis of PCOS and highlight that PCOS may arise due to excess androgen exposure in fetal life. Previous reports from our laboratory found

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34

Fieschi, Jacques. "Production d'anticorps anti-steroides-mutagenese des paratopes." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22005.

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Les specificites des deux anticorps anti-cortisol ont ete modifiees par mutagenese. Les genes codant pour les anticorps ont ete introduits dans un vecteur d'expression procaryote sous controle d'un promoteur inductible. Les fragments d'anticorps produits forment des corps d'inclusion insolubles. Une fusion a ete realisee entre un fragment d'anticorps et la mbp (proteine affine du maltose) mais la proteine est egalement insoluble. Par contre, cette fusion est presente dans le milieu de culture sous une forme soluble et active quand elle est exprimee dans une souche dont les proteines periplasmi

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35

LE, MELLAY VERONIQUE. "Signalisation membranaire des steroides dans les osteoblastes." Paris 6, 1998. http://www.theses.fr/1998PA066549.

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Les hormones sexuelles et la vitamine d jouent un role essentiel dans le remaniement osseux. Le mecanisme d'action classique de ces steroides passe par l'activation de recepteurs cytosoliques/ nucleaires qui modulent l'expression de genes specifiques. Dans le tissu osseux, seuls les osteoblastes (ob), cellules responsables de la formation de la matrice organique et de sa mineralisation, possedent de tels recepteurs. Cependant, certains effets biologiques de ces steroides ne peuvent pas s'expliquer par ce mode d'action classique steroides. En effet, l'stradiol et le calcitriol, metabolite actif

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36

Awah, Edmund Kpabi. "Regulation of the indoleamines by sex steroids." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1004114.

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Alteration of serum tryptophan leads to parallel alterations in brain tryptophan levels. Such changes in brain tryptophan levels has been shown to lead to mood disturbances. The primary enzyme responsible for altering serum tryptophan levels is the liver cytosolic enzyme, tryptophan pyrrolase. Activation of this enzyme is responsible for the enhanced catabolism of circulating tryptophan. The purpose of the present study was firstly to establish whether there is a link between sex steroids and tryptophan pyrrolase activity especially since sex steroids are also known to cause mood disturbances

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37

Yeon, Kim. "Cardiotonic Steroids and the Sodium Potassium Pump." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25992.

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Cardiotonic steroids (CTSs), such as digoxin, are used to treat heart failure as they inhibit the sodium potassium pump (NKP). However, sporadic studies report NKP stimulation by a CTS called ouabain. This thesis investigates such reports and explores mechanisms for stimulation. Rabbit cardiomyocytes were isolated and voltage clamped, and the NKP current (Ip) identified. Exposure of myocytes to 5 nM or 10 nM ouabain for ~1-minute significantly increased Ip to 0.69±0.09 pA/pF (N=6) and 0.64±0.05 pA/pF respectively vs. 0.46±0.03 pA/pF in 25 controls. Rostafuroxin, a putative ouabain antagonist,

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38

Gandikota, Jyothi Swaroop Parish Edward J. "Studies on the synthesis of B-ring 6-azasteroids." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Theses/GANDIKOTA_JYOTHI_56.pdf.

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39

Barraclough, Dominic Jocelyn. "Synaptic transmission and long-term potentiation in subfield CA1 of the rat hippocampus during oestrous cycle, pregnancy and oestradiol treatment." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262809.

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40

Ng, Kathleen Sau-kwan. "Globalization and higher education reform : the dialectic of global and local forces in shaping higher education policy in Hong Kong, 1989-2000." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247213.

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41

Riedner, Jens. "Towards a second generation of steroid-derived enantioselective carboxylate receptors." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390650.

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42

Marchetti, Nicholas Ian. "Steroids and development of the rat Wolffian duct." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/24898.

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The aims of the studies described in this thesis were threefold. Firstly, to establish an in vitro culture system for the Wolffian ducts; secondly, to elucidate the role of androgens in the development and differentiation of the Wolffian duct from day 19 p.c. onwards, and finally to examine the impact of steroids and steroidogenic compounds on protein expression in the developing Wolffian duct. Immunoexpression of six markers was examined in the freshly isolated Wolffian duct on days 19.5 p.c. through to d0, the day of birth: the androgen receptor (AR), the two oestrogen receptors (ERα and ERβ

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43

Chin, Eunice Hannah. "Steroids and sexual differentiation of the songbird brain." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/32110.

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Sexual differentiation of the songbird brain has traditionally thought to be driven by gonadal testosterone (T) and estradiol (E2). Recent studies have indicated that other sources of sex steroids may be responsible. Moreover, these alternative sources may release precursors, such as dehydroepiandrosterone (DHEA), which are subsequently converted downstream to sex steroids, such as E2, only at target tissues. This thesis examines plasma and tissue hormone profiles during development and possible alternative sources of sex steroids, including the adrenals, brain and liver, during the nes

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44

Spence, John Cochrane. "Anabolic-androgenic steroids, a series of meta-analyses." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0019/NQ44811.pdf.

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45

Bi, Honggang. "Urinary metabolites of anabolic steroids : identification and synthesis." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70304.

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The metabolism of several anabolic 17$ alpha$-methyl steroids, namely formebolone, mestanolone, methandienone, methyltestosterone, oxandrolone, oxymetholone and stanozolol, were investigated. The identification of metabolites was based on GC/MS analysis of different derivatives, and chemical synthesis of corresponding reference steroids. Common metabolic reactions have been studied and structure-metabolism relationships were discussed. New biotransformation routes, such as oxidative pathways of 2-formyl and 2-hydroxymethylene steroids, have been unveiled. The mechanism of 17-epimerization of t

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46

Buchanan, H. J. "The synthesis and structure elucidation of organotin-steroids." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592189.

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The thesis was concerned with the synthesis structures and activity and reactivities of stannylated steroid derivatives. Most attention has been paid to cholesterol and cholestene derivatives. Directly bonded stannylated cholestene derivatives have been obtained by various routes. 3α-triphenylstannylcholest-5-ene was obtained from the regiospecific reaction of Ph<SUB>3</SUB>SnLi with cholesteryl sulphonates; 3β-triorganostannylcholest-5-ene was obtained by the regiospecific reaction of Ph<SUB>3</SUB>SnCl with 3β-chloromagnesiocholest-5-ene. The Barbieri-type reaction of Ph<SUB>3</SUB>SnCl and

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47

Bandpey, Zhale. "Biphasic regulation of hippocampal neurogenesis by adrenal steroids." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608250.

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48

Nippe, Stefanie [Verfasser]. "Injectable drug delivery systems for steroids / Stefanie Nippe." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1068809787/34.

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49

ZHAO, WENJUN. "Analysis of most common endogenous steroids in plasma." Thesis, Uppsala universitet, Analytisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-225664.

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50

Ebner, Martin Johannes. "Molecular characterisation of steroids in the mammalian brain." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248377.

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