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Journal articles on the topic 'Stevia crystal'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

S., R. Das, S. M. E. Istiak A., Hazra P., Habiba U., K. H. Bhuiyan M., and Rafiq K. "Effects of Crystal Derived from Stevia rebaudiana Leaves on Alloxan Induced Type-1 Diabetic Mice." British Journal of Pharmaceutical Research 17, no. 2 (2017): 1–11. https://doi.org/10.9734/BJPR/2017/33740.

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The study was undertaken to investigate the antidiabetic effects of crystals derived from <em>Stevia rebaudiana </em>leaves in normal rats and alloxan induced diabetic mice. Normal rats were used to evaluate whether the stevia crystal have any adverse effects on body weight and blood glucose of healthy rats. The rats were divided into two groups (n=5); healthy control rats and stevia treated healthy rats (1 g/kg/day orally). To evaluate the antidiabetic effects of stevia crystal, mice were divided into five equal (n=5) groups; healthy control, diabetic control, stevia crystal @ 250 and 500 mg/

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2

Satar-AlDavdi, Khanda Sirwan. "Investigation of the effect of sucrose substitution with Stevia on the structure, physicochemical and sensory properties of ice cream." Halabja University Journal 7, no. 2 (2022): 198–208. http://dx.doi.org/10.32410/huj-10417.

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 Abstract: Consumption of milk and its products is considered as one of the indicators of human societies' development. Ice cream as one of the most popular milk products around the world has many fans but due to its high amount of sucrose has negative effects on health. Stevia, a natural sweetener, was used as a sucrose substitute at 0-100% replacement levels in ice cream formulation. To investigate the treatments produced, physicochemical properties in ice cream including specific gravity, viscosity, melting time of the first drop, melting amount, overrun. The results showed that

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3

Arslaner, Ayla, Mehmet Ali Salık, Salih Özdemir, and Ahmet Akköse. "Yogurt ice cream sweetened with sucrose, stevia and honey: Some quality and thermal properties." Czech Journal of Food Sciences 37, No. 6 (2019): 446–55. http://dx.doi.org/10.17221/311/2018-cjfs.

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This study investigated the effects of some sweeteners (sucrose, honey and stevia) on the quality and thermal properties of plain (P) and cocoa (C) yogurt ice cream. For this purpose, six different yogurt ice cream samples were prepared with sucrose (control: AP, AC), with honey (BP, BC) and with stevia (CP, CC). The highest values of protein, ash, fat, lactose ratios and lightness (L*) were measured in samples with stevia. The addition of honey increased the b* values. The addition of cocoa increased pH and viscosity, but decreased overrun ratios. Although the addition of stevia reduced the l

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4

Rana, Abi Surya, Tetiana Haniastuti, and Nur Rahman Ahmad Seno Aji. "STEVIA LEAF EXTRACT (STEVIA REBAUDIANA BERTONI M.) INHIBITS STREPTOCOCCUS SANGUINIS ATCC 10556 BIOFILM FORMATION IN VITRO." Berkala Ilmiah Kedokteran Duta Wacana 10, no. 1 (2025): 11–16. https://doi.org/10.21460/bikdw.v10i1.1120.

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Background: Oral biofilms play a significant role in oral diseases such as caries and periodontal diseases. Streptococcus sanguinis is a key component in the development of oral biofilms. Biofilm formation can be inhibited by using anti-adhesion and antibacterial substances contained in plants. Stevia leaves (Stevia rebaudiana Bertoni M.) contain flavonoids, alkaloids, and tannins, which may possess anti-adhesion and antibacterial properties. Objective: The purpose of this study was to determine the effect of a stevia leaf extract on the inhibition of S. sanguinis ATCC 10556 biofilm formation.

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5

Deviyanti, Sinta, Nurani Hayati, and Silva Abraham. "Aktivitas Hambatan Biofilm Larutan Irigasi Ekstrak Daun Stevia rebaudiana Bertoni Terhadap Candida albicans." SONDE (Sound of Dentistry) 10, no. 1 (2025): 1–13. https://doi.org/10.28932/sod.v10i1.10723.

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Candida albicans merupakan jamur oportunistic yang sering dijumpai pada infeksi saluran akar gigi. Kemampuannya membentuk biofilm pada dentin dinding saluran akar gigi, menyebabkan peningkatan virulensi dan resistensinya terhadap NaOCL sebagai gold standard larutan irigasi. Ekstrak daun Stevia rebaudiana Bertoni diketahui bersifat antijamur terhadap Candida albicans, namun data penelitian aktivitas terhadap pembentukan biofilm Candida albicans sangat terbatas. Penelitian ini bertujuan menganalisis aktivitas hambatan biofilm larutan irigasi ekstrak daun Stevia rebaudiana Bertoni terhadap jamur

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6

AlKanderi, Sara, Monerah AlFreeh, Radhika G. Bhardwaj, and Maribasappa Karched. "Sugar Substitute Stevia Inhibits Biofilm Formation, Exopolysaccharide Production, and Downregulates the Expression of Streptococcal Genes Involved in Exopolysaccharide Synthesis." Dentistry Journal 11, no. 12 (2023): 267. http://dx.doi.org/10.3390/dj11120267.

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Background: Acid production by sucrose fermentation disturbs the balance in dental plaque by lowering the oral pH. As a consequence of the profound effect of sucrose on caries initiation and progression, many studies have been directed towards finding non-cariogenic artificial sweeteners that can be used as a substitute to sucrose. Existing literature shows that dietary sucrose upregulates the expression of biofilm associated genes involved in exopolysaccharide (EPS) production. Objective: In this study, we aimed to investigate the effect of the sugar substitute stevia on biofilm formation, EP

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7

Sinta, Deviyanti, Abraham Silva, and Hayati Nurani. "Antibiofilm Potential of Stevia Rebaudiana Bertoni Leaf Extract Irrigated Solution against The Bacteri Enterococcus Faecalis ATCC 29212." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 04, no. 12 (2024): 980–90. https://doi.org/10.5281/zenodo.14546028.

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Disinfection of dental root canals 2.5% NaOCL is still a challenge related to its toxicity and the virulence of <em>Enterococcus faecalis </em>which is able to form biofilms in dental root canals<em>. </em>There is no evidence on the antibiofilm ability of <em>Stevia rebaudiana </em>Bertoni leaf extract against <em>Enterococcus faecalis</em>.   <strong>Objective: </strong>To evaluate the efficacy of Stevia rebaudiana Bertoni leaf extract irrigant in preventing Enterococcus faecalis biofilm formation.   <strong>Materials and Methods: </strong>Th

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8

Rojas-Pérez, Rodrigo E., Ernestina Cedillo-Portugal, Pedro Joseph-Nathan, and Eleuterio Burgueño-Tapia. "A New Longipinene Diester from Stevia Monardifolia Kunth." Natural Product Communications 4, no. 6 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400603.

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Nonpolar and medium polarity fractions from whole plant methanolic extracts of Stevia monardifolia afforded the new 7β-angeloyloxy-8α-isovaleroyloxylongipin-2-en-1-one 1 along with known 7β,8α-diangeloyloxylongipin-2-en-1-one 2 and 7β,8α-diangeloyloxylongipinan-1-one 3. Alkaline hydrolysis of a mixture of 1 and 2 gave 7β,8α-dihydroxylongipin-2-en-1-one 4 which was subjected to a single crystal X-ray diffraction study. The new compound 1, which is the third 7β,8α-dihydroxylongipin-2-en-1-one diester natural product isolated from a Stevia especies, was fully characterized by one-and two-dimensio

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9

Calderon, José S., Leovigildo Quijano, Federjco Gómez-Garibay, Donato M. Sanchez, Tirso Rios, and Frank R. Fronczek. "Sesquiterpene lactones from Stevia ovata and crystal structure of 11,13-dehydroeriolin." Phytochemistry 26, no. 6 (1987): 1747–50. http://dx.doi.org/10.1016/s0031-9422(00)82281-5.

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10

Lee, Soon Goo, Eitan Salomon, Oliver Yu, and Joseph M. Jez. "Molecular basis for branched steviol glucoside biosynthesis." Proceedings of the National Academy of Sciences 116, no. 26 (2019): 13131–36. http://dx.doi.org/10.1073/pnas.1902104116.

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Steviol glucosides, such as stevioside and rebaudioside A, are natural products roughly 200-fold sweeter than sugar and are used as natural, noncaloric sweeteners. Biosynthesis of rebaudioside A, and other related stevia glucosides, involves formation of the steviol diterpenoid followed by a series of glycosylations catalyzed by uridine diphosphate (UDP)-dependent glucosyltransferases. UGT76G1 fromStevia rebaudianacatalyzes the formation of the branched-chain glucoside that defines the stevia molecule and is critical for its high-intensity sweetness. Here, we report the 3D structure of the UDP

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11

Das, S., A. Istiak, P. Hazra, U. Habiba, M. Bhuiyan, and K. Rafiq. "Effects of Crystal Derived from Stevia rebaudiana Leaves on Alloxan Induced Type-1 Diabetic Mice." British Journal of Pharmaceutical Research 17, no. 2 (2017): 1–11. http://dx.doi.org/10.9734/bjpr/2017/33740.

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12

Perera, Wilmer, Ion Ghiviriga, Douglas Rodenburg, et al. "Tetra-glucopyranosyl Diterpene ent-Kaur-16-en-19-oic Acid and ent-13(S)-Hydroxyatisenoic Acid Derivatives from a Commercial Extract of Stevia rebaudiana (Bertoni) Bertoni." Molecules 23, no. 12 (2018): 3328. http://dx.doi.org/10.3390/molecules23123328.

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Stevia rebaudiana and its diterpene glycosides are one of the main focuses of food companies interested in developing novel zero calorie sugar substitutes since the recognition of steviol glycosides as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration. Rebaudioside A, one of the major steviol glycosides of the leaves is more than 200 times sweeter than sucrose. However, its lingering aftertaste makes it less attractive as a table-top sweetener, despite its human health benefits. Herein, we report the purification of two novel tetra-glucopyranosyl diterpene g

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13

Mallikarjuna, Koduru, Omaima Nasif, Sulaiman Ali Alharbi, et al. "Phytogenic Synthesis of Pd-Ag/rGO Nanostructures Using Stevia Leaf Extract for Photocatalytic H2 Production and Antibacterial Studies." Biomolecules 11, no. 2 (2021): 190. http://dx.doi.org/10.3390/biom11020190.

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Continuously increasing energy demand and growing concern about energy resources has attracted much research in the field of clean and sustainable energy sources. In this context, zero-emission fuels are required for energy production to reduce the usage of fossil fuel resources. Here, we present the synthesis of Pd-Ag-decorated reduced graphene oxide (rGO) nanostructures using a green chemical approach with stevia extract for hydrogen production and antibacterial studies under light irradiation. Moreover, bimetallic nanostructures are potentially lime lighted due to their synergetic effect in

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14

Renko, Miha, Ajda Taler-Verčič, Marko Mihelič, Eva Žerovnik, and Dušan Turk. "Partial rotational lattice order–disorder in stefin B crystals." Acta Crystallographica Section D Biological Crystallography 70, no. 4 (2014): 1015–25. http://dx.doi.org/10.1107/s1399004714000091.

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At present, the determination of crystal structures from data that have been acquired from twinned crystals is routine; however, with the increasing number of crystal structures additional crystal lattice disorders are being discovered. Here, a previously undescribed partial rotational order–disorder that has been observed in crystals of stefin B is described. The diffraction images revealed normal diffraction patterns that result from a regular crystal lattice. The data could be processed in space groupsI4 andI422, yet one crystal exhibited a notable rejection rate in the higher symmetry spac

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15

Badawy, Alaa M., Medhat Taha, Sara T. Elazab та ін. "Targeting of Nrf2/PPARγ/NLRP3 Signaling Pathway by Stevia rebudiana Bertoni Extract Provides a Novel Insight into Its Protective Effect against Acute Gouty Arthritis-Induced Synovial Inflammation, Oxidative Stress and Apoptosis in a Rat Model". Processes 10, № 9 (2022): 1751. http://dx.doi.org/10.3390/pr10091751.

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Our research work examined the potential protection of Stevia rebaudiana extract against monosodium urate crystals (MSU)-induced acute gouty arthritis in a rat model and its possible underlying mechanism. Forty rats were allocated into four groups (n = 10); a control group; an MSU group, whose rats received 0.1 of MSU single intra-articular injection in the ankle joint on the fifth day of the experiment; an MSU + Stevia group, which received 250 mg/kg/day of Stevia extract orally for seven days and MSU crystals on the fifth day; and an MSU + colchicine group, which was administered colchicine

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16

الحمداني, حمدية محمد شهوان. "STUDY THE SENSORY PROPERTIES OF SOME TYPES OF JUICES THAT MADE BY USING NATURAL SWEETENER POWDER (Stevia rebaudiana)." iraqi journal of market research and consumer protection 12, no. 2 (2020): 162–72. http://dx.doi.org/10.28936/jmracpc12.2.2020.(15).

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Increased diseases and obesity currently due to increased production and excessive consumption of foods manufactured from non-food sweeteners without attention to the risk of consuming those additional high calories due to consuming these refreshing products such as juices and other various drinks, especially in the summer season by most segments of Iraqi society, especially workers, children and school students the aim of this study. Therefore, the study designed to replace sucrose with 0.03, 0.04 and 0.05% of each of the white stevia crystals and milled dry stevia leaves in the laboratory ma

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17

Bal-Prylypko, Larysa, Mykola Nikolaenko, Taisiia Volkhova, et al. "The study of functional and technological properties of vegetarian ice cream." Potravinarstvo Slovak Journal of Food Sciences 17 (February 27, 2023): 110–21. http://dx.doi.org/10.5219/1798.

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The use perspective and expediency of plant-based milk, enriched with fiber when combined with organic products, biobased products, and sugar substitute products, has been substantiated in the manufacturing process of vegetarian ice cream. When combined with pumpkin fiber, stevia, bananas, pistachios, coconut oil, and coffee beans with different functional and technological properties, rice milk has a purposeful influence on organoleptic and Physico-chemical properties of food products. Accordingly, the expediency of added rice milk (62%) has been determined to optimize vegetarian ice cream's

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18

Žganec, Matjaž, Ajda Taler Verčič, Igor Muševič, Miha Škarabot, and Eva Žerovnik. "Amyloid Fibrils of Stefin B Show Anisotropic Properties." International Journal of Molecular Sciences 24, no. 4 (2023): 3737. http://dx.doi.org/10.3390/ijms24043737.

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Human stefin B, a member of the cystatin family of cysteine protease inhibitors, tends to form amyloid fibrils under relatively mild conditions, which is why it is used as a model protein to study amyloid fibrillation. Here, we show for the first time that bundles of amyloid fibrils, i.e., helically twisted ribbons, formed by human stefin B exhibit birefringence. This physical property is commonly observed in amyloid fibrils when stained with Congo red. However, we show that the fibrils arrange in regular anisotropic arrays and no staining is required. They share this property with anisotropic

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19

Mooradian, Arshag D. "In search for an alternative to sugar to reduce obesity." International Journal for Vitamin and Nutrition Research 89, no. 3-4 (2019): 113–17. http://dx.doi.org/10.1024/0300-9831/a000531.

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Abstract. Consumption of table sugar has been increasing despite the warnings of public health officials as to the potential adverse consequences of sugar consumption. The World Health Organization recommends restricting consumption of sugars to no more than 10% of daily caloric intake, with a proposal to lower this level to 5% or less for optimal health. Unfortunately substituting sugar with the currently available artificial sweeteners does not appear to have favorable clinical effects. Given the health-related concerns with the currently available sweeteners such as increased risk of obesit

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20

Jenko, Saša, Iztok Dolenc, Gregor Gunčar, Andreja Doberšek, Marjetka Podobnik, and Dušan Turk. "Crystal Structure of Stefin A in Complex with Cathepsin H: N-terminal Residues of Inhibitors can Adapt to the Active Sites of Endo- and Exopeptidases." Journal of Molecular Biology 326, no. 3 (2003): 875–85. http://dx.doi.org/10.1016/s0022-2836(02)01432-8.

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21

Stubbs, M. T., B. Laber, W. Bode, et al. "The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction." EMBO Journal 9, no. 6 (1990): 1939–47. http://dx.doi.org/10.1002/j.1460-2075.1990.tb08321.x.

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22

Kadirvel, Nithila, Suganya Selvam, Sathish Shankar, and Ramya Ramadoss. "EVALUATION OF THE ANTI-CARIOGENIC PROPERTY OF STEVIA REBAUDIANA - BASED NOVEL LOZENGES." BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, May 15, 2025. https://doi.org/10.58240/1829006x-2025.21.4-210.

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Background & Aim:Dental caries is a widespread oral health issue predominantly caused by Streptococcus mutans, a bacterium known for its ability to form biofilms on tooth surfaces. The use of non-cariogenic sweeteners with potential therapeutic benefits offers a promising strategy for caries prevention. Stevia rebaudiana, a natural plant-based sweetener, has shown antimicrobial properties, but its application in child-friendly formulations such as lozenges remains underexplored. This study aimed to develop lozenges using Stevia rebaudiana and evaluate their antibacterial and antibiofilm ef

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23

Deviyanti, Sinta, Silva Abraham, and Nurani Hayati. "Antibiofilm Potential of Stevia Rebaudiana Bertoni Leaf Extract Irrigated Solution against The Bacteri Enterococcus Faecalis ATCC 29212." International Journal of Pharmaceutical and Bio-Medical Science 04, no. 12 (2024). https://doi.org/10.47191/ijpbms/v4-i12-10.

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Disinfection of dental root canals 2.5% NaOCL is still a challenge related to its toxicity and the virulence of Enterococcus faecalis which is able to form biofilms in dental root canals. There is no evidence on the antibiofilm ability of Stevia rebaudiana Bertoni leaf extract against Enterococcus faecalis. Objective: To evaluate the efficacy of Stevia rebaudiana Bertoni leaf extract irrigant in preventing Enterococcus faecalis biofilm formation. Materials and Methods: This in vitro study utilized a Post-Test Only Control Group Design. Stevia rebaudiana Bertoni leaf extract irrigants were seri

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24

Guo, Baodang, Xiaodong Hou, Yan Zhang, et al. "Highly efficient production of rebaudioside D enabled by structure-guided engineering of bacterial glycosyltransferase YojK." Frontiers in Bioengineering and Biotechnology 10 (August 25, 2022). http://dx.doi.org/10.3389/fbioe.2022.985826.

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Owing to zero-calorie, high-intensity sweetness and good taste profile, the plant-derived sweetener rebaudioside D (Reb D) has attracted great interest to replace sugars. However, low content of Reb D in stevia rebaudiana Bertoni as well as low soluble expression and enzymatic activity of plant-derived glycosyltransferase in Reb D preparation restrict its commercial usage. To address these problems, a novel glycosyltransferase YojK from Bacillus subtilis 168 with the ability to glycosylate Reb A to produce Reb D was identified. Then, structure-guided engineering was performed after solving its

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25

Mulat, Mulugeta, Fazlurrahman Khan, and Archana Pandita. "Chemical composition and antibacterial, anti-biofilm and antivirulence activities of plant extracts against human pathogenic bacteria." Natural Products Journal 10 (May 27, 2020). http://dx.doi.org/10.2174/2210315510999200527142244.

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Background: Bacterial multi-drug resistance is one of the serious issues in the worldwide. The majority of drug resistance developed by bacteria is derived from the formation of biofilm and the production of several virulence factors. Objective: To combat the emerging drug resistance nature of bacteria, we have used some medicinal plants such as Stevia rebaudiana, Cymbopogon flexuosus, Matricaria chamomilla, Ocimum sanctum, Phyllanthus amarus and Thymus vulgaris for the extraction of active molecules that can inhibit the biofilm formation and bacterial growth. Materials & Methods: Each ext

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