Academic literature on the topic 'Stifel, Michael'

Michael Borgolte stellt seinem monumentalen Werk eine Reihe von Zitaten voran: ,,Wenn der Mensch nach seinem Tode übrigbleibt, werden seine Taten auf einen Haufen neben ihn gelegt. Das Dortsein währt ewig!“, so steht es in den Lehren für Pharao Merikare aus dem 22./20. Jahrhundert vor unserer Zeitrechnung. Worte wie diese umreißen das Thema, das schon vor Jahrhunderten Menschen so sehr bewegte, dass sie Botschaften wie diese in Stein schlugen. Sie wollten wissen, ob und wie ihr Verhalten und Wirken auf Erden nach ihrem Tod summiert und beurteilt wird und welche Folgen diese Einschätzungen haben werden: für das Andenken, das ihnen unter den Lebenden gewährt wird und auch für ihr eigenes nachirdisches Dasein. Um diese nachmortale Bilanzierung ihres Lebens positiv zu beeinflussen, stellten sie der Allgemeinheit für gute Zwecke Geld und Gut zur Verfügung, d.h. sie ,,stifteten“. Stiftungen, so Borgolte, sind als ,,totales soziales Phänomen erkannt..., an denen (sic) sich das Gefüge ganzer Gesellschaften ablesen lässt“ (9). Denn die Motivationen der Stifter, die Größe, Art und Ausgestaltung ihrer Donationen, deren Wirkungen auf Dauer usw. lassen Rückschlüsse zu über Jenseitsvorstellungen, Mentalitäten, Machtstrukturen im Wandel. Seit über 30 Jahren beschäftigt Borgolte sich mit dem Thema ,,Stiftungen“, und aus seiner Feder sowie seiner Schule sind bereits zahlreiche Werke hervorgegangen, die jeweils thematisch, regional und chronologisch begrenzte Fragestellungen über das Stiftungswesen erforschten. Während dieses zunächst vor allem vor dem Hintergrund christlicher Spiritualität des Mittelalters verstanden wurde, sind im Laufe der Zeit mehr und mehr ältere sowie außereuropäische Kulturen und Religionen in den Fokus einer vergleichenden Betrachtung Borgoltes getreten. Im Rahmen seines umfangreichen Projekts, das durch den Advanced Grant des ,European Research Council’ ermöglicht wurde, arbeiteten in den letzten Jahren Spezialisten für europäische, afrikanische und asiatische Religionen zusammen über Beispiele <?page nr="263"?>stifterischer Aktivitäten der alten und vormodernen Kulturen auf den drei Kontinenten.

Dominique Barjot, Rémi Baudouï and Danièle Voldman, eds., Les Reconstructions en Europe (1945–1949) (Paris: Editions Complexe, 1997), 342 pp., FF175, ISBN 2-870-27693-1. Matthias Kipping and Ove Bjarnar, eds., The Americanisation of European Business: The Marshall Plan and the Transfer of US Management Models (London: Routledge, 1998), 235 pp., £50.00, ISBN 0-415-17191-1. Jeffry M. Diefendorf, Axel Frohn and Hermann-Josef Rupieper, eds., American Policy and the Reconstruction of Western Germany, 1945–1955 (Cambridge: Cambridge University Press and the German Historical Institute, Washington, DC, 1993), 537 pp., £45.00, ISBN 0-521-43120-4. Hans-Herbert Holzamer and Marc Hoch, eds., Der Marshall-Plan: Geschichte und Zukunft (Landsberg/Lech: Olzog, 1997), 214 pp., ISBN 3-789-29349-0. Haus der Geschichte der Bundesrepublik Deutschland, 50 Jahre Marshall-Plan (Berlin: Argon Verlag, Berlin, 1997), 140 pp., ISBN 3-870-24387-2. Günter Bischof, Anton Pelinka and Dieter Stiefel, eds., The Marshall Plan in Austria (New Brunswick: Transaction Publishers, 2000), 588 pp., ISBN 0-765-80679-7. Michael Kennedy and Joseph Morrison Skelly, eds., Irish Foreign Policy 1919–1966: From Independence to Internationalism (Dublin: Four Courts Press, 2000), 352 pp., £39.50, ISBN 1-851-82404-9. Bernadette Whelan, Ireland and the Marshall Plan 1947–1957 (Dublin: Four Courts Press, 2000), 426 pp., £39.50, ISBN 1-851-82517-7. Charles Silva, Keep Them Strong, Keep them Friendly: Swedish–American Relations and the Pax Americana, 1948–1952 (Stockholm: Akademitryck AB, 1999), 376 pp., Kl.10.00, ISBN 9-171-53974-3. Chiarello Esposito, America's Feeble Weapon: Funding the Marshall Plan in France and Italy, 1948–1950 (Westport: Greenwood Press, 1994), 226 pp., £49.50, ISBN 0-313-29340-6. Fernando Guirao, Spain and the Reconstruction of Western Europe 1945–57 (London: Macmillan, 1998), 240 pp., ISBN 0-312-21291-7. Martin A. Schain, Marshall Plan Fifty Years After (Houndmills: Palgrave, 2001), £30.00, ISBN 0-333-92983-7 was published after this article went to press.

AbstractWhen, in the early 1980s the ideas of post-structuralism seemed rampant within academic critical theory, the appearance of the flawed English translation of Mikhail Bakhtin's central essays on the novel seemed to offer a very promising alternative perspective.1 Bakhtin's model of discursive relations promised to guard the specificity of discourse from being obscured by a web of determinations, while allowing the development of an account of the operations of power and resistance in discourse that could avoid the nullity of Derrida's hors-texte and the irresponsible semiotic hedonism of the later Barthes. Marxist theorists such as Raymond Williams, Terry Eagleton and Allon White immediately and effectively seized upon the translated work of the Bakhtin circle to bolster their arguments, but, as translations of the earlier and later philosophical material appeared, it became apparent that the relationship between work of the circle and the Marxist tradition was very problematic. With this, the American anti-Marxist Slavists – some of whom had been responsible for certain of these translations – moved onto the offensive, arguing that Bakhtin's work was fundamentally incompatible with, and in principle hostile to, Marxism. Occasionally, they went further, arguing that Bakhtin was quite unconcerned with politics and questions of power, being an ethical, or even a religious philosopher before all else. The Americans did have a point. Bakhtin certainly was not a Marxist and the Marxism of some of his early colleagues and collaborators was of a rather peculiar sort. Furthermore, the key problematic area was indeed Bakhtin's ethics which, it became ever more apparent, underlies his most critically astute and productive work and serves to blunt its political edge. Important points of contact between the work of the Bakhtin circle and Marxist theory do persist, however, as Ken Hirschkop and Michael Gardiner, among others, have continued to register. In this article, examining some of the sources of Bakhtin's philosophy, which have only just been revealed in the new Russian edition of his work, we shall analyse the features of Bakhtin's ethics that stifle the political potential of dialogic criticism, and we will suggest ways in which that potential may be liberated.

Hydrogels with spatiotemporally tunable mechanical properties have been increasingly employed for studying the impact of tissue mechanics on cell fate processes. These dynamic hydrogels are particularly suitable for recapitulating the temporal stiffening of a tumor microenvironment. To this end, we have reported an enzyme-mediated stiffening hydrogel system where tyrosinase (Tyrase) was used to stiffen orthogonally crosslinked cell-laden hydrogels. Herein, a mathematical model was proposed to describe enzyme diffusion and reaction within a highly swollen gel network, and to elucidate the critical factors affecting the degree of gel stiffening. Briefly, Fick’s second law of diffusion was used to predict enzyme diffusion in a swollen poly(ethylene glycol) (PEG)-peptide hydrogel, whereas the Michaelis–Menten model was employed for estimating the extent of enzyme-mediated secondary crosslinking. To experimentally validate model predictions, we designed a hydrogel system composed of 8-arm PEG-norbornene (PEG8NB) and bis-cysteine containing peptide crosslinker. Hydrogel was crosslinked in a channel slide that permitted one-dimensional diffusion of Tyrase. Model predictions and experimental results suggested that an increasing network crosslinking during stiffening process did not significantly affect enzyme diffusion. Rather, diffusion path length and the time of enzyme incubation were more critical in determining the distribution of Tyrase and the formation of additional crosslinks in the hydrogel network. Finally, we demonstrated that the enzyme-stiffened hydrogels exhibited elastic properties similar to other chemically crosslinked hydrogels. This study provides a better mechanistic understanding regarding the process of enzyme-mediated dynamic stiffening of hydrogels.

Background:VOYAGE 1, a phase-3, double-blinded, placebo- and active comparator-controlled study evaluated the efficacy and safety of guselkumab (GUS; a fully human anti-interleukin-23 monoclonal antibody) in patients with moderate-to-severe plaque psoriasis.1,2,3Objectives:To assess the efficacy and safety through 5 years of continuous GUS treatment.Methods:In VOYAGE 1, patients were randomized to GUS 100 mg at Weeks 0, 4, 12, then every 8 weeks (q8w); placebo at Weeks 0, 4, 12 followed by GUS 100 mg at Weeks 16, 20 then q8w; or adalimumab 80 mg at Week 0, 40 mg at Week 1, then 40 mg every 2 weeks (q2w) through Week 47. At Week 52, all patients continued open-label GUS through Week 252. Efficacy assessments included proportions of patients achieving ≥90% or 100% improvement in Psoriasis Area and Severity Index (PASI 90, PASI 100), and Investigator’s Global Assessment scores of cleared/minimal or cleared (IGA 0/1, IGA 0). Three statistical methods were used to analyze efficacy: prespecified Treatment Failure Rules (TFR), Nonresponder Imputation (NRI), and As Observed (OBS). For TFR analyses, patients who discontinued study agent due to lack of efficacy, worsening of psoriasis, or use of a protocol-prohibited psoriasis treatment were considered nonresponders. For NRI analyses, patients with missing efficacy data (regardless of the reason) after application of TFR were counted as nonresponders. For OBS analyses, missing data were not imputed. Safety was assessed through Week 264.Results:Among a total of 494 patients randomized to GUS at Week 0 (N=329) and placebo patients who crossed over to GUS at Week 16 (N=165), 76.9% (380/494) continued study agent through Week 252. PASI 90 responses were well-maintained with up to 5 years of continuous GUS use. At Week 52, PASI 90 response rates were 79.7%, 75.5%, and 80.6% based on TFR, NRI, and OBS analyses, respectively; corresponding rates at Week 252 were 84.1%, 66.6%, and 86.6%. Likewise, PASI 100, IGA 0/1, and IGA 0 responses were maintained from Week 52 through Week 252 (Table 1). Efficacy was also maintained through Week 252 in patients randomized to GUS at Week 0 (N=329). Through the end of the study for all patients (GUS group and adalimumab→GUS crossover group; N=774), the proportion of patients reporting at least one adverse event (AE), serious AE, or discontinuation due to AEs were 87.7%, 16.4%, and 6.1%, respectively. Rates of AEs of interest through Week 264 were as follows: serious infections (2.8%), malignancies (nonmelanoma skin cancer [1.7%]; cancer other than nonmelanoma skin cancer [2.3%]), major adverse cardiovascular events (1.0%), and suicidal ideation and behavior (0.6%).Conclusion:High efficacy response rates were maintained (regardless of the method used to analyze data) and no new safety concerns were identified through 5 years of continuous GUS treatment in VOYAGE 1.References:[1]Blauvelt A et al. J Am Acad Derm 2017;76:405-417[2]Griffiths CEM et al. J Drugs Dermatol 2018;17:826-832[3]Griffiths CEM et al. J Dermatol Treat 2020;13:1-9Table 1.Proportion of Patients in the GUS Groupa Achieving Clinical Responses by Analysis Type at Week 52 and Week 252Week 52Week 252TFR (N=468)(%)NRI (N=494)(%)OBS (N=463)(%)TFR (N=391)(%)NRI (N=494)(%)OBS (N=380)(%) PASI 90 77.9 75.5 80.6 84.1 66.686.6 PASI 100 49.7 46.6 49.7 52.741.7 54.2 IGA 0 84.6 80.2 85.582.4 65.2 84.7IGA 0 53.3 50.854.254.743.356.3GUS, guselkumab; IGA, Investigator’s Global Assessment; NRI, nonresponder imputation method; OBS, As Observed method; PASI, Psoriasis Area and Severity Index; TFR, treatment failure rules methodaIncludes patients randomized to GUS and placebo patients who crossed over to GUS at Week 16Disclosure of Interests:Christopher E.M. Griffiths Speakers bureau: AbbVie, Eli Lilly, Janssen, Leo, Novartis, Pfizer, Sandoz, and Sun Pharma, Consultant of: AbbVie, Eli Lilly, Janssen, Leo, Novartis, Pfizer, Sandoz, and Sun Pharma, Grant/research support from: AbbVie, Eli Lilly, Janssen, Leo, Novartis, Pfizer, Sandoz, and Sun Pharma, Kim Papp Speakers bureau: AbbVie, Amgen, Astellas, Baxalta, Baxter, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Centocor, Dermira, Eli Lilly, Forward Pharma, Galderma, Genentech, GlaxoSmithKline, Janssen, Kyowa-Hakko Kirin, Leo Pharma, MedImmune, Merck-Serono, Merck Sharp & Dohme, Novartis, Pfizer, Regeneron, Roche, Sanofi-Genzyme, Stiefel, Sun Pharma, Takeda, UCB, and Valeant, Consultant of: AbbVie, Amgen, Astellas, Baxalta, Baxter, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Centocor, Dermira, Eli Lilly, Forward Pharma, Galderma, Genentech, GlaxoSmithKline, Janssen, Kyowa-Hakko Kirin, Leo Pharma, MedImmune, Merck-Serono, Merck Sharp & Dohme, Novartis, Pfizer, Regeneron, Roche, Sanofi-Genzyme, Stiefel, Sun Pharma, Takeda, UCB, and Valeant, Grant/research support from: AbbVie, Amgen, Astellas, Baxalta, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Centocor, Dermira, Eli Lilly, Galderma, Genentech, GlaxoSmithKline, Janssen, Kyowa-Hakko Kirin, Leo Pharma, MedImmune, Merck-Serono, Merck Sharp & Dohme, Novartis, Pfizer, Regeneron, Roche, Sanofi-Genzyme, Stiefel, Takeda, UCB, and Valeant, Michael Song Shareholder of: Johnson and Johnson, Employee of: Janssen Research & Development, LLC, Megan Miller Shareholder of: Johnson and Johnson, Employee of: Janssen Research & Development, LLC, Yin You Shareholder of: Johnson and Johnson, Employee of: Janssen Research & Development, LLC, Yaung-Kaung Shen Shareholder of: Johnson and Johnson, Employee of: Janssen Research & Development, LLC, Andrew Blauvelt Speakers bureau: AbbVie, Consultant of: AbbVie, Aclaris, Almirall, Arena, Athenex, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, Dermira, Eli Lilly, FLX Bio, Forte, Galderma, Janssen, Leo, Novartis, Ortho, Pfizer, Regeneron, Sandoz, Sanofi Genzyme, Sun Pharma, and UCB Pharma.

Data is central in almost all scientific disciplines nowadays. Furthermore, intelligent systems have developed rapidly in recent years, so that in many disciplines the expectation is emerging that with the help of intelligent systems, significant challenges can be overcome and science can be done in completely new ways. In order for this to succeed, however, first, fundamental research in computer science is still required, and, second, generic tools must be developed on which specialized solutions can be built. In this paper, we introduce a recently started collaborative project funded by the Carl Zeiss Foundation, a virtual manufactory for digitization in the sciences, the “Werkstatt”, which is being established at the Michael Stifel Center Jena (MSCJ) for data-driven and simulation science to address fundamental questions in computer science and applications. The Werkstatt focuses on three key areas, which include generic tools for machine learning, knowledge generation using machine learning processes, and semantic methods for the data life cycle, as well as the application of these topics in different disciplines. Core and pilot projects address the key aspects of the topics and form the basis for sustainable work in the Werkstatt.

Alex Abou-Chebl, MD Michael Abraham, MD Joseph E. Acker, III, EMT-P, MPH Robert Adams, MD, MS, FAHA Eric Adelman, MD Opeolu Adeoye, MD DeAnna L. Adkins, PhD Maria Aguilar, MD Absar Ahmed, MD Naveed Akhtar, MD Rufus Akinyemi, MBBS, MSc, MWACP, FMCP(Nig) Karen C. Albright, DO, MPH Felipe Albuquerque, MD Andrei V. Alexandrov, MD Abdulnasser Alhajeri, MD Latisha Ali, MD Nabil J. Alkayed, MD, PhD, FAHA Amer Alshekhlee, MD, MSc Irfan Altafullah, MD Arun Paul Amar, MD Pierre Amarenco, MD, FAHA, FAAN Sepideh Amin-Hanjani, MD, FAANS, FACS, FAHA Catherine Amlie-Lefond, MD Aaron M. Anderson, MD David C. Anderson, MD, FAHA Sameer A. Ansari, MD, PhD Ken Arai, PhD Agnieszka Ardelt, MD, PhD Juan Arenillas, MD PhD William Armstead, PhD, FAHA Jennifer L. Armstrong-Wells, MD, MPH Negar Asdaghi, MD, MSc, FRCPC Nancy D. Ashley, APRN,BC, CEN,CCRN,CNRN Stephen Ashwal, MD Andrew Asimos, MD Rand Askalan, MD, PhD Kjell Asplund, MD Richard P. Atkinson, MD, FAHA Issam A. Awad, MD, MSc, FACS, MA (hon) Hakan Ay, MD, FAHA Michael Ayad, MD, PhD Cenk Ayata, MD Aamir Badruddin, MD Hee Joon Bae, MD, PhD Mark Bain, MD Tamilyn Bakas, PhD, RN, FAHA, FAAN Frank Barone, BA, DPhil Andrew Barreto, MD William G. Barsan, MD, FACEP, FAHA Nicolas G. Bazan, MD, PhD Kyra Becker, MD, FAHA Ludmila Belayev, MD Rodney Bell, MD Andrei B. Belousov, PhD Susan L. Benedict, MD Larry Benowitz, PhD Rohit Bhatia, MBBS, MD, DM, DNB Pratik Bhattacharya, MD MPh James A. Bibb, PhD Jose Biller, MD, FACP, FAAN, FAHA Randie Black Schaffer, MD, MA Kristine Blackham, MD Bernadette Boden-Albala, DrPH Cesar Borlongan, MA, PhD Susana M. Bowling, MD Monique M. B. Breteler, MD, PhD Jonathan Brisman, MD Allan L. Brook, MD, FSIR Robert D. Brown, MD, MPH Devin L. Brown, MD, MS Ketan R. Bulsara, MD James Burke, MD Cheryl Bushnell, MD, MHSc, FAHA Ken Butcher, MD, PhD, FRCPC Livia Candelise, MD S Thomas Carmichael, MD, PhD Bob S. Carter, MD, PhD Angel Chamorro, MD, PhD Pak H. Chan, PhD, FAHA Seemant Chaturvedi, MD, FAHA, FAAN Peng Roc Chen, MD Jun Chen, MD Eric Cheng, MD, MS Huimahn Alex Choi, MD Sherry Chou, MD, MMSc Michael Chow, MD, FRCS(C), MPH Marilyn Cipolla, PhD, MS, FAHA Kevin Cockroft, MD, MSc, FACS Domingos Coiteiro, MD Alexander Coon, MD Robert Cooney, MD Shelagh B. Coutts, BSc, MB.ChB., MD, FRCPC, FRCP(Glasg.) Elizabeth Crago, RN, MSN Steven C. Cramer, MD Carolyn Cronin, MD, PhD Dewitte T. Cross, MD Salvador Cruz-Flores, MD, FAHA Brett L. Cucchiara, MD, FAHA Guilherme Dabus, MD M Ziad Darkhabani, MD Stephen M. Davis, MD, FRCP, Edin FRACP, FAHA Deidre De Silva, MBBS, MRCP Amir R. Dehdashti, MD Gregory J. del Zoppo, MD, MS, FAHA Bart M. Demaerschalk, MD, MSc, FRCPC Andrew M. Demchuk, MD Andrew J. DeNardo, MD Laurent Derex, MD, PhD Gabrielle deVeber, MD Helen Dewey, MB, BS, PhD, FRACP, FAFRM(RACP) Mandip Dhamoon, MD, MPH Orlando Diaz, MD Martin Dichgans, MD Rick M. Dijkhuizen, PhD Michael Diringer, MD Jodi Dodds, MD Eamon Dolan, MD, MRCPI Amish Doshi, MD Dariush Dowlatshahi, MD, PhD, FRCPC Alexander Dressel, MD Carole Dufouil, MD Dylan Edwards, PhD Mitchell Elkind, MD, MS, FAAN Matthias Endres, MD Joey English, MD, PhD Conrado J. Estol, MD, PhD Mustapha Ezzeddine, MD, FAHA Susan C. Fagan, PharmD, FAHA Pierre B. Fayad, MD, FAHA Wende Fedder, RN, MBA, FAHA Valery Feigin, MD, PhD Johanna Fifi, MD Jessica Filosa, PhD David Fiorella, MD, PhD Urs Fischer, MD, MSc Matthew L. Flaherty, MD Christian Foerch, MD Gregg C. Fonarow, MD, FAHA Andria Ford, MD Christine Fox, MD, MAS Isabel Fragata, MD Justin Fraser, MD Don Frei, MD Gary H. Friday, MD, MPH, FAAN, FAHA Neil Friedman, MBChB Michael Froehler, MD, PhD Chirag D. Gandhi, MD Hannah Gardener, ScD Madeline Geraghty, MD Daniel P. Gibson, MD Glen Gillen, EdD, OTR James Kyle Goddard, III, MD Daniel A. Godoy, MD, FCCM Joshua Goldstein, MD, PhD, FAHA Nicole R. Gonzales, MD Hector Gonzalez, PhD Marlis Gonzalez-Fernandez, MD, PhD Philip B. Gorelick, MD, MPH, FAHA Matthew Gounis, PhD Prasanthi Govindarajan, MD Manu Goyal, MD, MSc Glenn D. Graham, MD, PhD Armin J. Grau, MD, PhD Joel Greenberg, PhD, FAHA Steven M. Greenberg, MD, PhD, FAHA David M. Greer, MD, MA, FCCM James C. Grotta, MD, FAHA Jaime Grutzendler, MD Rishi Gupta, MD Andrew Gyorke, MD Mary N. Haan, MPH, DrPH Roman Haberl, MD Maree Hackett, PhD Elliot Clark Haley, MD, FAHA Hen Hallevi, MD Edith Hamel, PhD Graeme J. Hankey, MBBS, MD, FRCP, FRCP, FRACP Amer Haque, MD Richard L. Harvey, MD Don Heck, MD Cathy M. Helgason, MD Thomas Hemmen, MD, PhD Dirk M. Hermann, MD Marta Hernandez, MD Paco Herson, PhD Michael D. Hill, MD, MSc, FRCPC Nancy K. Hills, PhD, MBA Robin C. Hilsabeck, PhD, ABPP-CN Judith A. Hinchey, MD, MS, FAHA Robert G. Holloway, MD, MPH William Holloway, MD Sherril K. Hopper, RN Jonathan Hosey, MD, FAAN George Howard, DPH, FAHA Virginia J. Howard, PhD, FAHA David Huang, MD, PhD Daniel Huddle, DO Richard L. Hughes, MD, FAHA, FAAN Lynn Hundley, RN, MSN, ARNP, CCRN, CNRN, CCNS Patricia D. Hurn, PhD, FAHA Muhammad Shazam Hussain, MD, FRCPC Costantino Iadecola, MD Rebecca N. Ichord, MD M. Arfan Ikram, MD Kachi Illoh, MD Pascal Jabbour, MD Bharathi D. Jagadeesan, MD Vivek Jain, MD Dara G. Jamieson, MD, FAHA Brian T. Jankowitz, MD Edward C. Jauch, MD, MS, FAHA, FACEP David Jeck, MD Sayona John, MD Karen C. Johnston, MD, FAHA S Claiborne Johnston, MD, FAHA Jukka Jolkkonen, PhD Stephen C. Jones, PhD, SM, BSc Theresa Jones, PhD Anne Joutel, MD, PhD Tudor G. Jovin, MD Mouhammed R. Kabbani, MD Yasha Kadkhodayan, MD Mary A. Kalafut, MD, FAHA Amit Kansara, MD Moira Kapral, MD, MS Navaz P. Karanjia, MD Wendy Kartje, MD, PhD Carlos S. Kase, MD, FAHA Scott E. Kasner, MD, MS, FAHA Markku Kaste, MD, PhD, FESO, FAHA Prasad Katakam, MD, PhD Zvonimir S. Katusic, MD Irene Katzan, MD, MS, FAHA James E. Kelly, MD Michael Kelly, MD, PhD, FRCSC Peter J. Kelly, MD, MS, FRCPI, ABPN (Dip) Margaret Kelly-Hayes, EdD, RN, FAAN David M. Kent, MD Thomas A. Kent, MD Walter Kernan, MD Salomeh Keyhani, MD, MPH Alexander Khalessi, MD, MS Nadia Khan, MD, FRCPC, MSc Naim Naji Khoury, MD, MS Chelsea Kidwell, MD, FAHA Anthony Kim, MD Howard S. Kirshner, MD, FAHA Adam Kirton, MD, MSc, FRCPC Brett M. Kissela, MD Takanari Kitazono, MD, PhD Steven Kittner, MD, MPH Jeffrey Kleim, PhD Dawn Kleindorfer, MD, FAHA N. Jennifer Klinedinst, PhD, MPH, MSN, RN William Knight, MD Adam Kobayashi, MD, PhD Sebastian Koch, MD Raymond C. Koehler, PhD, FAHA Ines P. Koerner, MD, PhD Martin Köhrmann, MD Anneli Kolk, PhD, MD John B. Kostis, MD Tobias Kurth, MD, ScD Peter Kvamme, MD Eduardo Labat, MD, DABR Daniel T. Lackland, BA, DPH, FAHA Kamakshi Lakshminarayan, MD, PhD Joseph C. LaManna, PhD Catherine E. Lang, PT, PhD Maarten G. Lansberg, MD, PhD, MS Giuseppe Lanzino, MD Paul A. Lapchak, PhD, FAHA Sean Lavine, MD Ronald M. Lazar, PhD Marc Lazzaro, MD Jin-Moo Lee, MD, PhD Meng Lee, MD Ting-Yim Lee, PhD Erica Leifheit-Limson, PhD Enrique Leira, MD, FAHA Deborah Levine, MD, MPh Joshua M. Levine, MD Steven R. Levine, MD Christopher Lewandowski, MD Daniel J. Licht, MD Judith H. Lichtman, PhD, MPH David S. Liebeskind, MD, FAHA Shao-Pow Lin, MD, PhD Weili Lin, PhD Ute Lindauer, PhD Italo Linfante, MD Lynda Lisabeth, PhD, FAHA Alice Liskay, RN, BSN, MPA, CCRC Warren Lo, MD W. T. Longstreth, MD, MPH, FAHA George A. Lopez, MD, PhD David Loy, MD, PhD Andreas R. Luft, MD Helmi Lutsep, MD, FAHA William Mack, MD Mark MacKay, MBBS, FRACP Jennifer Juhl Majersik, MD Marc D. Malkoff, MD, FAHA Randolph S. Marshall, MD John H. Martin, PhD Alexander Mason, MD Masayasu Matsumoto, MD, PhD Elizabeth Mayeda, MPH William G. Mayhan, PhD Avi Mazumdar, MD Louise D. McCullough, MD, PhD Erin McDonough, MD Lisa Merck, MD, MPH James F. Meschia, MD, FAHA Steven R. Messe, MD Joseph Mettenburg, MD,PhD William Meurer, MD BA Brett C. Meyer, MD Robert Mikulik, MD, PhD James M. Milburn, MD Kazuo Minematsu, MD, PhD J Mocco, MD, MS Yousef Mohammad, MD MSc FAAN Mahendranath Moharir, MD, MSc, FRACP Carlos A. Molina, MD Joan Montaner, MD PhD Majaz Moonis, MD, MRCP Christopher J. Moran, MD Henry Moyle, MD, PhD Susanne Muehlschlegel, MD, MPH Susanne Muehlschlegel, MD, MPH Yuichi Murayama, MD Stephanie J. Murphy, VMD, PhD, DACLAM, FAHA Fadi Nahab, MD Andrew M. Naidech, MD, MPh Ashish Nanda, MD Sandra Narayanan, MD William Neil, MD Edwin Nemoto, PhD, FAHA Lauren M. Nentwich, MD Perry P. Ng, MD Al C. Ngai, PhD Andrew D. Nguyen, MD, PhD Thanh Nguyen, MD, FRCPC Mai Nguyen-Huynh, MD, MAS Raul G. Nogueira, MD Bo Norrving, MD Robin Novakovic, MD Thaddeus Nowak, PhD David Nyenhuis, PhD Michelle C. Odden, PhD Michael O'Dell, MD Christopher S. Ogilvy, MD Jamary Oliveira-Filho, MD, PhD Jean Marc Olivot, MD, PhD Brian O'Neil, MD, FACEP Bruce Ovbiagele, MD, MSc, FAHA Shahram Oveisgharan, MD Mayowa Owolabi, MBBS,MWACP,FMCP Aditya S. Pandey, MD Dhruvil J. Pandya, MD Nancy D. Papesh, BSN, RN, CFRN, EMT-B Helena Parfenova, PhD Min S. Park, MD Matthew S. Parsons, MD Aman B. Patel, MD Srinivas Peddi, MD Joanne Penko, MS, MPH Miguel A. Perez-Pinzon, PhD, FAHA Paola Pergami, MD, PhD Michael Phipps, MD Anna M. Planas, PhD Octavio Pontes-Neto, MD Shyam Prabhakaran, MD, MS Kameshwar Prasad, MD, DM, MMSc, FRCP, FAMS Charles Prestigiacomo, MD, FAANS, FACS G. Lee Pride, MD Janet Prvu Bettger, ScD, FAHA Volker Puetz, MD, PhD Svetlana Pundik, MD Terence Quinn, MD, MRCP, MBChb (hons), BSc (hons) Alejandro Rabinstein, MD Mubeen Rafay, MB.BS, FCPS, MSc Preeti Raghavan, MD Venkatakrishna Rajajee, MD Kumar Rajamani, MD Peter A. Rasmussen, MD Kumar Reddy, MD Michael J. Reding, MD Bruce R. Reed, PhD Mathew J. Reeves, BVSc, PhD, FAHA Martin Reis, MD Marc Ribo, MD, PhD David Rodriguez-Luna, MD, PhD Charles Romero, MD Jonathan Rosand, MD Gary A. Rosenberg, MD Michael Ross, MD, FACEP Natalia S. Rost, MD, MA Elliot J. Roth, MD, FAHA Christianne L. Roumie, MD, MPH Marilyn M. Rymer, MD, FAHA Ralph L. Sacco, MS, MD, FAAN, FAHA Edgar A. Samaniego, MD, MS Navdeep Sangha, BS, MD Nerses Sanossian, MD Lauren Sansing, MD, MSTR Gustavo Saposnik, MD, MSc, FAHA Eric Sauvageau, MD Jeffrey L. Saver, MD, FAHA, FAAN Sean I. Savitz, MD, FAHA Judith D. Schaechter, PhD Lee H. Schwamm, MD, FAHA Phillip Scott, MD, FAHA Magdy Selim, MD, PhD, FAHA Warren R. Selman, MD, FAHA Souvik Sen, MD, MS, MPH, FAHA Frank Sharp, MD, FAHA, FAAN George Shaw, MD, PhD Kevin N. Sheth, MD Vilaas Shetty, MD Joshua Shimony, MD, PhD Yukito Shinohara, MD, PhD Ashfaq Shuaib, MD, FAHA Lori A. Shutter, MD Cathy A. Sila, MD, FAAN Gisele S. Silva, MD Brian Silver, MD Daniel E. Singer, MD Robert Singer, MD Aneesh B. Singhal, MD Lesli Skolarus, MD Eric E. Smith, MD Sabrina E. Smith, MD, PhD Christopher Sobey, PhD, FAHA J David Spence, MD Christian Stapf, MD Joel Stein, MD Michael F. Stiefel, MD, PhD Sophia Sundararajan, MD, PhD David Tanne, MD Robert W. Tarr, MD Turgut Tatlisumak, MD, PhD, FAHA, FESO Charles H. Tegeler, MD Mohamed S. Teleb, MD Fernando Testai, MD, PhD Ajith Thomas, MD Stephen Thomas, MD, MPH Bradford B. Thompson, MD Amanda Thrift, PhD, PGDipBiostat David Tong, MD Michel Torbey, MD, MPH, FCCM, FAHA Emmanuel Touze, MD, PhD Amytis Towfighi, MD Richard J. Traystman, PhD, FAHA Margaret F. Tremwel, MD, PhD, FAHA Brian Trimble, MD Georgios Tsivgoulis, MD Tanya Turan, MD, FAHA Aquilla S. Turk, DO Michael Tymianski, MD, PhD, FRCSC Philippa Tyrrell, MB, MD, FRCP Shinichiro Uchiyama, MD, FAHA Luis Vaca, MD Renee Van Stavern, MD Susan J. Vannucci, PhD Dale Vaslow, MD, PHD Zena Vexler, PhD Barbara Vickrey, MD, MPH Ryan Viets, MD Anand Viswanathan, MD, PhD Salina Waddy, MD Kenneth R. Wagner, PhD Lawrence R. Wechsler, MD Ling Wei, MD Theodore Wein, MD, FRCPC, FAHA Babu Welch, MD David Werring, PhD Justin Whisenant, MD Christine Anne Wijman, MD, PhD Michael Wilder, MD Joshua Willey, MD, MS David Williams, MB, BAO, BCh, PhD, Dip.Med.Tox, FRCPE, FRCPI Linda Williams, MD Olajide Williams, MD, MS Dianna Willis, PhD John A. Wilson, MD, FACS Jeffrey James Wing, MPH Carolee J. Winstein, PhD, PT, FAPTA Max Wintermark, MD Charles Wira, MD Robert J. Wityk, MD, FAHA Thomas J. Wolfe, MD Lawrence Wong, MD Daniel Woo, MD, MS Clinton Wright, MD, MS Guohua Xi, MD Ying Xian, MD, PhD Dileep R. Yavagal, MD Midori A. Yenari, MD, FAHA William L. Young, MD Darin Zahuranec, MD Allyson Zazulia, MD, FAHA Adina Zeki Al Hazzouri, PhD John H. Zhang, MD, PhD Justin Zivin, MD, PhD, FAHA Richard Zorowitz, MD, FAHA Maria Cristina Zurru, MD

St. Michael the Archangel is a biblical icon the Spanish brought to Mexico during the sixteenth century. He was used for evangelization as part of a religious discourse incorporating icons as its principal tool, strongly impacting indigenous people. Considered a leader of God’s armies fighting against evil, Michael became the patron saint of soldiers. Danza de Migueles is a Mexican ritual dance-drama about the fight between good and evil, still performed each year by Nahuas and Totonacas indigenous people of Puebla and Veracruz. It reinvents the military attributes of a Catholic icon within the frame of Mesoamerican religions, shaping indigenous identity with new ways of cultural resistance. This chapter addresses changes and reinterpretations that St. Michael’s iconography underwent when placed in a dancing context and how it has served the Nahuas from Tzinacapan in building their identity as a distinct ethnic group in contemporary Mexico.

This essay takes Solli’s and Condry’s essays as examples of possibilities worth emulating. Both essays, Titlestad argues, are refined instances of a refusal to adopt simple dialectical or bilateral understandings or analyses. Both describe the use of aspects of “American” culture (country and rap music respectively, as well as their social-symbolic architecture) in dynamic processes of triangulation that link their origins (in the United States), their destinations (Norway and Japan respectively), and third terms demarcated by the context and political priorities of performers and their publics. Titlestad is interested in a question he sees both essays fundamentally asking, namely, how particular communities put aspects of U.S. culture to work. In both essays, Titlestad argues, the work entails a redefinition, a resetting, indeed a productive consumption of cultural practice, something Titlestad prefers to think of as some form of improvisation but that still captures the need to complicate any sense of bilateralism. Clearly, Titlestad argues, the particular Norwegian and Japanese communities and subcultures described in the essays by Solli and Condry are embroiled in transnational imaginaries in which “America” already circulates as shorthand for a number of contemporary ideological proclivities.

How are e-government and Internet policy organised and developed in different countries? This comprehensively revised volume answers this question and addresses the latest developments within the amended framework of digitalisation, such as cybersecurity, data protection, open government and e-democracy, among others. With contributions by Ana Azurmendi, Christoph Bieber, Jérôme Brugger, Emiliana De Blasio, Robert Dewar, Myriam Dunn Cavelty, Marianne Fraefel, Annette Knaut, Marianne Kneuer, Stine Marg, Véronique Millim, Manuel Misgeld, Matt Poelmans, Alessia, C. Neuroni, Simon P. Rinas, Patrick Ruestchmann, Ulrich Sarcinelli, Wolf J. Schünemann, Welf Schröter, Michele Sorice, Stefan Steiger, Sebastian Stier, Sophie Valdenaire-Ratto and Maria A. Wimmer.

The metaphor of the ‘invisible hand’ not only characterises Smith’s understanding of competitive processes in free markets but also his theory of political liberalism. Smithʼs theory of economic and political liberalism is based on the assumption of autonomous processes in the development of morality, laws and the social order. These processes lead to a natural harmony of individual interests in politics and economics. However, Smith does not associate these ideas with the demand for a minimal state. Instead, he assigns the state a much more active role than is generally assumed. The analyses in this book of Smith’s reception by authors in the 19th century (in the US and Germany) and of his relevance for current analyses of political challenges show that the question of which conditions need to be fulfilled to ensure the stability of liberal societies is still a crucial one in political philosophy and science. With contributions by Michael Aßländer, Christel Fricke, Hendrik Hansen, Michael Hochgeschwender, Tobias Knobloch, Tim Kraski, Heinz D. Kurz, Birger Priddat, Bastian Ronge, Rolf Steltemeier, Richard Sturn

Although Parliament had officially closed the London commercial stages in 1642 and many of the old theaters including the Globe and the King’s Masquing House were destroyed, throughout the Commonwealth period illicit performances continued. Newsbooks record raids on illicit performances in the remaining theatres. The 1650s also saw an increase in printed play texts, often expressing royalist sympathies Many of the actors including Michael Mohun and Charles Hart served in the King’s army. Entertainments were still performed in private houses, schools, and universities. Towards the end of the Commonwealth, William Davenant was permitted to stage ‘operas’ or moral representations.

This chapter discusses the landmark paper ‘Neuronal plasticity: increasing the gain in pain’, published by Woolf and Salter in 2000. Excellent review articles not only give a concise overview of a topic but also provide a framework for future research. In 2000, Clifford Woolf and Michael Salter joined forces to write one of the most highly cited review articles in the field of pain research and thus provided a conceptual framework for the plastic changes that occur in nociceptive neurons in response to chronic pain. With over 2,700 citations, this review is one of those rare articles that is still appreciated by pain researchers across domains.

This conference volume contains the written presentations of an Online-Conference held in March 2021 at the Technical University of Berlin with the topic: The "Law on the Mobilisation of Building Land" (currently still in draft form) - technical and legal issues. The work aims to provide an interesting overview of the new regulations, regulatory additions and requirements for planning practice. The "Act on the Mobilisation of Building Land" is intended to strengthen the possibilities of land access for the municipalities in order to be able to make a noticeable contribution to reducing the housing shortage in Germany in the area of housing supply, especially with regard to social housing promotion. With contributions by Malte Arndt, Ulrich Battis, Henning Jaeger, Stephan Mitschang, Christian-W. Otto, Olaf Reidt, Alexander Schink, Tim Schwarz, Gerhard Spieß and Michael Voigtländer.

The title—borrowed from The Wind in the Willows—is here re-purposed to cover four talks (the 2019 Clarendon Lectures) on four poems about boats; the ‘messing about’ is done by the poet and critic Michael Hofmann. In amiable, associative, exploratory terms, the writer discusses Rainer Maria Rilke’s ‘Emigrant Ship (Naples)’, Arthur Rimbaud’s ‘Drunken Ship’, Eugenio Montale’s ‘Boats on the Marne’, and Karen Solie’s ‘The World’. The suggestion is that there is a sort of symbolic equivalence between boat and poem, that the terms in which we think of boats and voyages are just as applicable to poets and poetry. The different boats, the different voyages, the different poems elicit an array of subtle, informative, and surprising responses. Taken as a whole, the lectures are four instances in how poetry, even across languages and translations, may still be read for enjoyment.

This chapter considers two questions that many people ask themselves (or should ask themselves). What is actually the difference between Nanosyntax (NS, Starke, 2009) and Distributed Morphology (DM, Halle and Marantz, 1993)? And which one of them is right? These questions remain as important now as they were some 15 years ago, when Michal Starke introduced the basics of the NS theory. Despite the fact that several written sources on NS have been available since 2007, there is still a lot of confusion about what NS actually is, and how NS and DM compare to each other. The present paper is an attempt to clear things up.

Friedrich Naumann (1860–1919) is one of the most exciting figures in German politics: a liberal champion of democracy, social policy, women’s emancipation and church reform, as well as a pioneer of political education—and at the same time a monarchist, patriot and fierce critic of his time. Many political and social trends of the early 20th century came together in the pastor and later leftist liberal party leader. His approaches to solving the problems of a highly industrialised society had a long-lasting effect and still evoke controversy when discussed today. This volume offers both an introduction to and new perspectives on his world of ideas; it is aimed at experts, students and all those interested in Naumann in equal measure. With contributions by Philippe Alexandre, Birgit Bublies-Godau, Norbert Friedrich, Jürgen Frölich, Ewald Grothe, Christoph Jahr, Wolther von Kieseritzky, Ursula Krey, Frank-Michael Kuhlemann, Anne C. Nagel, Ulrich Sieg, Ines Soldwisch and Peter Theiner.

Abstract Narrative is introduced as a cultural practice and life form which contributes to creating the foundation of our lives as it helps us to interpret the world, through stories, in which we must be able to act. Borrowed from Ricœur (Time and narrative: The configuration of time in fictional narrative (Vol. 2, K. McLaughlin & D. Pellauer, Trans). Chicago, IL: The University of Chicago Press (1985) and The course of recognition (D. Pellauer, Trans). Cambridge, MA: Harvard University Press (2005).), the concepts of time and space are presented as the contexts and products of narrative. The functions of storytelling are discussed under the heading of “technologies of Self-construction” (inspired by Foucault, Technologies of the self. In L. H. Martin, H. Gutman, & P. H. Hutton (Eds.), Technologies of the self: A seminar with Michel Foucault (pp. 16–49). Amherst, MA: The University of Massachusetts Press (1988).), which provide orientation, self-understanding, and transgression. These need to be developed within the constraints of social norms—so the theory goes—and yet subjects still have some room to move within the process of adopting norms (Butler, Giving an account of oneself. New York, NY: Fordham University Press (2005).).

AbstractSometimes, research can hit you in the stomach, making you angry and upset, possibly sick. With a bit of luck, this can be fine, as discontentment can be a force that propels you to become active and engage yourself. Sometimes, research can resonate in your heart, making you aware and empathetic. Not much luck is needed in these cases, as this will hopefully also stimulate you to get new ideas, a better understanding or hopefully even give you a better foothold for whatever you do in practice. Most of the time, research just passes you by, not leaving much of an impression. We do know that words can make a difference, that words can touch you. They evoke many different thoughts and emotions. It is not a single word alone that does this, it is the flow and rhythm of a text, how it takes the reader along, cognitively but also in space and time and in an embodied manner. To achieve different effects, we place words differently, we craft sentences that appeal to different senses and sensibilities, we use terms or jargon, we write complex sentences that juxtapose hosts of different qualities, as Michel Serres does in in The Five Senses (2008). We present a clear definition, we unfold arguments or put something to the point. Most of the word work we do, we do on our keyboards, sitting at a desk, in a train carriage or lying on a sofa. Thus, this word work happens remote from the site where our study took place, it is definitely not the same as the field work that we do, it is not the same as the numbers and algorithms that make up our data. But done well, it can still evoke the sense of what happens or happened “out there” in the field, the phenomena that the numbers point to, be they the numbers of people crossing a border or the feeling of someone who is lost or maybe even hunted (Guttorm, 2016).

Though Greek mathematics would have considered the notion of “irrational numbers” to be inherently contradictory, in the sixteenth century this concept found advocates on musical grounds well before it appeared in the theory of equations. Michael Stifel, the leading German mathematician of the century, first used the term “irrational numbers” in the context of his discussion of music, but then drew back from the infinity of digits implicit in this concept. Girolamo Cardano, the famous physician and mathematician, brought this concept forward in his musical writings and later used it in his treatment of algebra. Nicola Vicentino’s interest in reviving ancient Greek quarter-tones in enharmonic music led him to advocate “irrational proportions.” Each of their involvements with practical music and composition related closely to their mathematical views. Distrust of the irrational, both musical and mathematical, also color controversies about the expressive dissonances used in early opera, such as Giovanni Maria Artusi’s critique of Claudio Monteverdi. Throughout the book where various sound examples are referenced, please see http://mitpress.mit.edu/musicandmodernscience (please note that the sound examples should be viewed in Chrome or Safari Web browsers).

Michael moves to New Orleans, has eye-opening experiences in the French Quarter, and his first-semester grades suffer. Influential professors shape his love of learning and research. He encounters Alton Ochsner, Chief of Tulane Department of Surgery and a highly influential future mentor. He has dramatic and defining clinical experiences at New Orleans’ Mercy and Charity Hospitals. While still a medical student, Michael invents a new transfusion syringe. The legendary surgeon and polymath Rudolph Matas befriends the eager young Michael, becoming another revered role model. DeBakey graduates from medical school at the top of his class and decides to become a surgeon, training under Ochsner.

From his very first novel Whatever, Houellebecq has taken on the representation of the contemporary economy and asked in particular whether it still allows for a novelistic realism. Those concerns are continued in Houellebecq’s much more recent The Map and the Territory, which once again develops the question of realism in parallel to an investigation into economic value. Exploring this question across visual art (photography and painting) and literature (the novel), and with an emphatic interest in work, industrial objects, and those who produce those objects, The Map and the Territory ultimately reveals itself to be a detective novel that follows the deductive logic of the genre while simultaneously challenging that logic—a challenge that, in the novel, is explicitly formulated in economic terms as well, in other words as a challenge about the predictability of the markets. Thus, The Map and the Territory opens up onto the question of narrative in Meillassoux’s philosophy as discussed in Chapter Four.

Fibonacci’s Liber Abaci (The Book of Calculation) is the most important book of mathematics from the Middle Ages. The book was dedicated to Michael Scott, a Scottish scholar who was the Imperial Astrologer to the Holy Roman Emperor Frederick II. He was later described as a necromancer and was consigned to the eighth circle of Hell by Dante. Chapter 8 outlines the lives of Fibonacci and Michael Scott. Liber Abaci was key to the spread of Hindu–Arabic numerals through the Mediterranean and into Europe, and the book also includes a number of puzzles, the most famous of which is about breeding rabbits. The solution involves the number sequence now known as the Fibonacci sequence, which has many interesting properties that are still being studied.

The inhibition of the thrombin-mediated signal transfer by a common irreversible inhibitor Z of the factor Xa complex (Xc a) and thrombin has been analysed for the two-step process of the Xc a-triggered formation of thrombin andthe consecutive splitting ok a thrombin-specific substrate S. Assuming that both proteolytic processes follow simple Michaelis—Menten kinetics, that the inhibition reactions are second-order and that the prothrombin and irreversible inhibitor are in excess it can be shown that:1. clotting time (tc) is inversely proportional to the time-averaged thrombin concentration2. the endpoint of the conversion of the thrombin specific substrate S reached at exhaustion of thrombin and the Xc a is inversely proportional to the square of the inhibitor concentration3. the continously monitored thrombin generation inhibition is a more sensitive assay than the classical two-stage thrombin generation inhibition assay4. the shift in the effective concentration range of the continuously monitored thrombin generation inhibition assay relative to the continuously monitored anti-Xa assay and to that of the continuously monitored anti-IIa assay, depends on the initial rate of formation of thrombin with the thrombin generation inhibition assay and the original enzyme concentrations of the anti-enzyme assays.It can further be shown that the above conclusions still hold when the Z-mediated (with Z = anti thrombin III e.g.) inhibitions are potentiated by heparin(oid)s.

Turkish Gulets are motor-sailors that are still being built using wooden boatbuilding traditional construction in the Aegean and Mediterranean as well as being built using steel and cold moulded techniques. They are typical of the craft used for skippered charter tours in the region and exhibit good seakeeping in the shorter steep sea of the Mediterranean and also for manoeuvring in port and in anchorages. Usually this performance is at the cost of resistance. Sailing performance and stability are surprisingly not considered due to the large beams. The hull forms of two typical gulets are used to examine the stability, resistance and coupled heave and pitch. A multi-objective evolutionary optimization methodology is used to investigate the performance of the three objectives. The evaluation of resistance uses a transom modified Michell theory in keeping with the smaller L/B ratios and large transoms of many of these vessel types. Seakeeping is evaluated using a strip motion program and the stability curve is used to provide a stability index. The multi-objective analysis is based on the optimization capabilities of genetic algorithms. Evolutionary algorithms are stochastic in nature and follow the Darwinian principle of survival of the fittest. From a given population of hull candidates, those hulls that are “fitter” by having better resistance, seakeeping and stability are selected to generate a new population. Over the course of many generations, the hulls are optimized to provide better performance. Each of the objectives requires an index to measure the performance of the candidate.

The Polish film system is characterized by a variety of forms. Michał Zabłocki, the author of the comprehensive study of the «Organization of the production of feature film in Poland», isolates two models of world cinema: a producer and a producer – director. The first one features the dominant role of the producer, which means the person who is responsible for the work of all the film departments – direction, cinematography, production management, scenography and costume design. The second one, the model which is still the most popular in Poland, assumes close cooperation between the producer and the director.