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Journal articles on the topic 'Stiftelser'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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1

Høyland, Njaal Arne. "Skatteplikt for kapitalforvaltning i stiftelser." Skatterett 31, no. 03 (October 29, 2012): 256–66. http://dx.doi.org/10.18261/issn1504-310x-2012-03-08.

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2

Olsson, Katarina. "Geir Woxholth: Stiftelser etter stiftelsesloven 2001." Tidsskrift for Rettsvitenskap 118, no. 04-05 (February 7, 2006): 669–81. http://dx.doi.org/10.18261/issn1504-3096-2005-04-05-13.

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3

Furrebø, Susan T. "Allmennyttige stiftelser - hvor nyttige er de?" Stat & Styring 20, no. 04 (January 18, 2011): 51–55. http://dx.doi.org/10.18261/issn0809-750x-2010-04-20.

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4

Hammerich, Peter. "Noen spørsmål knyttet til kapitalforvaltning i stiftelser." Tidsskrift for forretningsjus 4, no. 03 (June 17, 2016): 3–23. http://dx.doi.org/10.18261/issn0809-9510-1998-03-01.

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5

Knudsen, Gudmund. "Finans- og sparebankstiftelsene – stiftelser i stiftelsesrettens grenseland." Lov og Rett 58, no. 03 (April 8, 2019): 131–32. http://dx.doi.org/10.18261/issn.1504-3061-2019-03-01.

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6

Namtvedt, Halvor. "Roller og ansvar i kapitalforvaltningen i norske stiftelser." Praktisk økonomi & finans 22, no. 02 (August 9, 2006): 85–93. http://dx.doi.org/10.18261/issn1504-2871-2006-02-11.

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7

PANUM., P. L. "Om Undersögelser angående sunde og syge Menneskers Kostrationer, särlig i Hospitaler, Stiftelser og Fängsler i forskellige Lande." Nordiskt Medicinskt Arkiv 16, no. 24 (April 24, 2009): 1–18. http://dx.doi.org/10.1111/j.0954-6820.1884.tb00144.x.

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Hammerich, Peter, and Markus Heistad. "Stiftelsers forvaltning av egen kapital." Tidsskrift for forretningsjus 15, no. 02 (June 13, 2016): 148–81. http://dx.doi.org/10.18261/issn0809-9510-2009-02-01.

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9

Moljord, Kåre I. "Om stiftelse og registrering av foretak." Lov og Rett 29, no. 07 (September 1, 1990): 431–40. http://dx.doi.org/10.18261/issn1504-3061-1990-07-05.

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10

Knudsen, Gudmund. "Stiftelsene - gammelt rettsinstitutt med nytt innhold." Lov og Rett 56, no. 09 (November 17, 2016): 523–24. http://dx.doi.org/10.18261/issn.1504-3061-2016-09-01.

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11

Ziegler, Berit. "Organisering af den danske boghandel Baggrunden for Boghandlerforeningens stiftelse 1837." Magasin fra Det Kongelige Bibliotek 10, no. 1 (June 4, 1995): 3–12. http://dx.doi.org/10.7146/mag.v10i1.66388.

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12

Hemström, Carl. "Om ändring av de bestämmelser som reglerar stiftelsers verksamhet – enligt svensk rätt." Tidsskrift for Rettsvitenskap 115, no. 01-02 (April 29, 2002): 187–213. http://dx.doi.org/10.18261/issn1504-3096-2002-01-02-13.

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13

Hansen, Hans Schultz. ""Så har vi dem igen" - kontinuitet og brud i det tyske mindretals ledelse hen over 1945." Sønderjydske Årbøger 126, no. 1 (January 1, 2015): 313–34. http://dx.doi.org/10.7146/soenderjydskeaarboeger.v126i1.113047.

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Maj 1945 blev også for det tyske mindretal »Stunde Null«. Dets institutioner lå billedligt talt i ruiner, og dets ledere og mange menige medlemmer blev interneret i Fårhuslejren og dømt under retsopgøret. I november 1945 begyndte genopbygningen af mindretallet med stiftelsen af Bund Deutscher Nordschleswiger på grundlag af en loyalitetserklæring til den danske stat. På dansk side tvivlede mange i begyndelsen på mindretallets nye bekendelse til 1920-grænsen og demokratiet. Især blev det bemærket, når personer med udpræget nazistisk fortid genindtog ledende poster i de nye organisationer. Arkiv- og forskningsleder Hans Schultz Hansen undersøger her omfanget af dette fænomen.
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14

Bing, Jon. "Edward Humphreys: Programformat och medier i konvergens. Formathandel, juridiskt skydd och branchpraxis. Stiftelsen etermedierna i Sverige,." Tidsskrift for Rettsvitenskap 125, no. 03 (September 5, 2012): 360–63. http://dx.doi.org/10.18261/issn1504-3096-2012-03-06.

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15

STADFELDT, A. "Om Virksomheden i Kjöbenhavns Födsels-stiftelse i Tidsrummet fra 1 April 1868 til 31 Marts 1869." Nordiskt Medicinskt Arkiv 1, no. 21 (April 24, 2009): 1–14. http://dx.doi.org/10.1111/j.0954-6820.1869.tb00018.x.

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16

Markussen, Åse. "Artotheks in Norway." Art Libraries Journal 12, no. 3 (1987): 25–28. http://dx.doi.org/10.1017/s0307472200005265.

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Artotheks, collections of works of art whose sole purpose is to be lent to the public, have existed in Norway since 1958/60. 7-8% of Norwegian public libraries developed rather small scale artothek-collections during the 60’s and early 70’s. After a period of decline and stagnation the activity was revitalized in 1983, through a pilot project based on the central organisation of acquisition, distribution, and circulation of original prints to six public libraries and hospital libraries, relieving them of all tasks except the actual lending routines. The culmination of this pilot project was the foundation of the Artothek Centre (Stiftelsen Artoteksentralen) in 1986. The Artothek Centre circulates small collections of prints to libraries throughout the country on a subscription basis, and has so far been a success. The prints are lent to the public free of charge.
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17

Larsen, Luna Skjoldann. "Ægteskab i transition." Tidsskrift for Islamforskning 13, no. 2 (December 10, 2019): 77–98. http://dx.doi.org/10.7146/tifo.v13i2.117770.

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Artiklen undersøger forandringer i tyrkisk-danske muslimers normer for ægteskab og parforhold. Dette gøres ud fra ni dybdegående, semistrukturerede interview med tyrkisk-danske muslimer, som er eller har været gift, og som er tilknyttet Dansk Tyrkisk Islamisk Stiftelse. Tidligere undersøgelser har vist, at der statistisk kan ses forandringer i ægteskabsmønstre, hvor eksempelvis skilsmisseraten er stigende for gruppen. Denne artikel vil komme med en mulig forklaring på, hvorfor parforholdsnormerne forandrer sig for unge tyrkisk-danske muslimer, ved at tage udgangspunkt i temaerne kønsroller i parforholdet og skilsmisse. Disse udgør konkrete eksempler på forandringspunkter, der både kan ses statistisk, og som informanterne italesatte. Artiklen belyser således, hvorfor unge tyrkisk-danske muslimer redefinerer rammerne for kærlighedsforhold, og hvordan de unges subjektivitet konstrueres igennem deres relation til islam, deres tyrkiske oprindelse og deres opvækst i Danmark.
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18

Forsman, Birgitta. "Nordiska Samfundets Stiftelse För Vetenskaplig Forskning Utan Djurförsok (The Swedish Fund for Scientific Research Without Animal Experiments)." Alternatives to Laboratory Animals 19, no. 1 (February 1991): 143–44. http://dx.doi.org/10.1177/026119299101900123.

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19

Holm, Nils G., Ruth Illman, Joakim Alander, and Björn Dahla. "Mystik blir vetenskap." Scripta Instituti Donneriani Aboensis 30 (March 21, 2021): 1–76. http://dx.doi.org/10.30674/scripta.102185.

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Den 29 mars 1956 i Dornach, Schweiz undertecknade Olly och Uno Donner ett donationsbrev som lade grunden för ett nytt forskningsinstitut i Åbo. De donerade sin egendom till Stiftelsen för Åbo Akademi för att grunda Donnerska institutet för religionshistorisk och kulturhistorisk forskning som en knutpunkt för forskningen kring religion och kultur, en mötespunkt för forskare, studerande och samhället i stort samt en utsikts­punkt mot stora världen, ny kunskap och nya idéer. Historiken ger en grundlig beskrivning av institutets uppkomsthistoria och de viktiga personer som under årens lopp bidragit till verksamheten. Den presenterar forskare och bibliotekarier, internationella symposier och kulturseminarier, forskningssatsningar och hyllkilometer av forskningslitteratur, forskarpris och stipendier, fester och vardag. Historiken speglar också den ämnesmässiga utveckling som skett inom religionsforskningen, både nationellt och internationellt, under den här tiden. Mystik blir vetenskap: Donnerska institutet 1956–2021 har skrivits av Nils G. Holm, professor emeritus i religionsvetenskap vid Åbo Akademi och långvarig styrelsemedlem vid institutet. Historiken är rikligt illustrerad med bilder från alla årtionden vid institutet.
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20

Kaustell, Kim O., Tiina E. A. Mattila, Anne Marie Heiberg, and Risto H. Rautiainen. "Vierastyövoiman työturvallisuuteen ja -terveyteen vaikuttavat tekijät." Suomen Maataloustieteellisen Seuran Tiedote, no. 28 (January 31, 2012): 1–6. http://dx.doi.org/10.33354/smst.75498.

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Suomalaiset puutarha- ja maatilayrittäjät palkkaavat vuosittain noin 15 000 ulkomaista työntekijää, pääasiassa kausityövoimaksi. Norjassa vastaava luku on 27000 (tiedot vuodelta 2007). Maatalous on yksi vaarallisimpia elinkeinoja, ja ulkomaalaistaustaisella työvoimalla on useiden tutkimusten mukaan kotimaista työvoimaa suurempi tapaturmariski. Ulkomaisen työntekijän tapaturmariskiä kasvattaa se, että hän on monessa riskiryhmässä samanaikaisesti. Tässä Pohjoismaisen ministerineuvoston rahoittamassa tutkimushankkeessa olivat mukana Norja, Ruotsi ja Suomi. Hankkeen tavoitteena oli tunnistaa työturvallisuuteen ja –terveyteen vaikuttavia tekijöitä mm. haastattelujen ja työntekijöiden itsedokumentoinnin (n=14) keinoin. Hankkeessa käytettiin hyväksi myös aiemmin vierastyövoimalle tehtyjä haastatteluja (n=40).Saadut tulokset vahvistavat aiemmissa tutkimuksissa saatuja tuloksia. Erityisiä kompastuskiviä työnteon turvallisuudelle ja terveellisyydelle olivat kielieroista johtuvat kommunikaatiovaikeudet, erot turvallisuusasenteissa, -tiedoissa ja –kulttuurissa, puutteellinen työkokemus sekä työntekijöiden pidättyvyys epäkohtien raportoinnissa työnantajalleen. Myös pitkät työpäivät sesongin aikana sekä urakkapalkkaus saattavat suoraan tai välillisesti nostaa tapaturmariskiä. Vakituisesti ulkomailla asuvien työntekijöiden koti-ikävä näyttää heikentävän työhyvinvointia. Jatkohankkeessa v. 2012–2013 tuloksista jalostetaan työkaluja, joita voidaan käyttää vierastyövoimaa palkkaavilla tiloilla mm. monipuolistamaan turvallisuuteen liittyvää kommunikaatiota ja koulutusta. Tutkimuskokonaisuutta rahoittavat Pohjoismainen ministerineuvosto, Työsuojelurahasto sekä Stiftelsen KSL Matmerk (Norja).
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21

Lilleholt, Kåre. "Anders Dahlquist-Sjöberg: Kommersiella hyresavtal. En avtalstyp i omvandling. Stiftelsen Skrifter utgivna av Juridiska fakulteten vid Stockholms universitet, Stockholm 1998. 530 s." Tidsskrift for Rettsvitenskap 112, no. 04 (August 1, 1999): 831–35. http://dx.doi.org/10.18261/issn1504-3096-1999-04-06.

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22

Larspers, Torbjörn. "Predikan som kommunikation av Evangeliet. Om C. O. Rosenii förkunnelsesätt speglat i bevarade predikoutkast från 1860-talet." Theofilos 12, no. 2-3 (February 26, 2021): 232–51. http://dx.doi.org/10.48032/theo/12/2/4.

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Carl Olof Rosenius (1816–1868) was one of Sweden’s most widely heard and highly esteemed preachers in his time. Many of his sermons were later printed in the magazine Pietisten and were spread in various reprints and editions. Most people who were influenced by Rosenius met his preaching and teaching through his printed words, but what was it like to hear Rosenius himself preach? How did his spoken words impress his contemporary listeners? To read an outlined, revised and printed sermon afterwards and to listen to it the moment it was delivered are two different things. In the written sermon the reader is not able to hear the preacher’s emphases, pauses, stresses etc. Readers don’t feel the pulse of the moment. Do we know the way in which Rosenius gave his sermons and the impression they made on his contemporary listeners? Since Rosenius has not been recorded we have to rely on various written sources giving at least glimpses of his sermon delivery. Some of these sources consist of eyewitness accounts of those who heard him preach and Rosenius’ own written remarks about his preaching. But there are also some sermon outlines on which he based his preaching. These outlines are kept in the archives of the Swedish Evangelical Mission, Evangeliska Fosterlands-Stiftelsen (EFS) (1856-), one of the institutions Rosenius helped establish, but they have been used very little by previous research. What can the study of these preserved sermon outlines tell us of Rosenius’ preaching method? Do they tell us more about his preparing and preaching?
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23

Bakoy, Eva. "Review : Michael Forsman: Från klubbrum till medielabyrint. Ungdomsprogram i radio och TV 1925- 1993 (From clubroom to media labyrinth. Youth programmes in radio and TV 1925-1993) Stiftelsen Etermedierna i Sverige, Stockholm 2000." YOUNG 9, no. 1 (February 2001): 73–75. http://dx.doi.org/10.1177/110330880100900106.

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24

Peters, L. "U. Bernitz / O. Wiklund (eds), Nordiskt lagstiftningssamarbete i det nya Europa, Stiftelsen Skrifter utgivna av Juridiska fakulteten vid Stockholms Universitet, Skriftserien nr 48, Juristfor-laget, Stockholm, 1996, 243 p., ISBN 91-7598-098-3, ISSN 0280-8056." Uniform Law Review - Revue de droit uniforme 2, no. 1 (January 1, 1997): 215. http://dx.doi.org/10.1093/ulr/2.1.215.

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25

Alemán, Freddy, and Sari Scheinberg. "EL PROGRAMA UNIVERSIDAD EMPRENDEDORA (PUE) EN NICARAGUA: ACTIVIDADES, PRODUCTOS Y RESULTADOS." La Calera 11, no. 16 (August 8, 2012): 50–56. http://dx.doi.org/10.5377/calera.v11i16.752.

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Las diez Universidades que conforman el Consejo Nacional de Universidades (CNU) en Nicaragua participaron en un programa (2007 a 2010) orientado a desarrollar el papel y la contribución de las Universidades en los procesos de innovación. El programa fue financiado por la Agencia Sueca para el Desarrollo Internacional (Asdi), y se basó en una metodología de acción-aprendizaje, en el cual las universidades compartían sus experiencias, competencias, estrategias y actividades entre ellas, así como, con otros actores claves en los sistemas de innovación. La Universidad Tecnológica de Chalmers, a través de la fundación Stiftelsen Chalmers Industriteknik (CIP) fue la contraparte sueca, con participación de investigadores de la escuela de tecnologías, gestión y economía, y el centro para estudios de propiedad intelectual (CIP). Los objetivos del programa fueron de extrema importancia para el desarrollo de las Universidades Nicaragüenses, y se asemejan a los retos y desafíos que las Universidades en todo el mundo enfrentan en el momento actual. En busca de la mejora de los procesos innovadores de las Universidades se definieron los siguientes objetivos: Desarrollar los roles y las responsabilidades que el CNU y las Universidades poseen en el sistema actual y futuro de innovación en Nicaragua, en asociación con otros grupos de claves en Nicaragua; generar las políticas que permitan a la Universidad incluir la innovación en su misión y prácticas; evaluar y mejorar el proceso de manejo de la investigación, incluyendo planes, diseños, métodos, construcción de relaciones y prácticas gerenciales que apoyarán la aplicabilidad e integración de las actividades de investigación y los resultados en la sociedad; desarrollar funciones, procesos y estructuras en las Universidades, que permitan que la innovación y el emprendedurismo sean integrados en su visión y prácticas, particularmente en el proceso de “investigación para el mercado”. Desarrollar a fondo el rol y la profesión del investigador, que incluyan contratos e incentivos para asegurar el desarrollo continuo de este grupo profesional desde una perspectiva de investigación e innovación; desarrollar una atmósfera y cultura en las Universidades (y el CNU) que estimulen transparencia, cooperación y aprendizaje, por medio del desarrollo de métodos de trabajo sistemáticos y conscientes, reflexionando y compartiendo; desarrollar habilidades y estrategias para proteger y extraer valor de la propiedad intelectual, basada en nuevos conocimientos y tecnologías generadas en las universidades, y por ultimo formar personal especializado a nivel de maestría, con el propósito de desarrollar habilidades locales en el área de propiedad intelectual y gerencia del capital intelectual. Este escrito presenta las acciones realizadas, los resultados y las conclusiones del programa. DOI: http://dx.doi.org/10.5377/calera.v11i16.752 La Calera Vol. 11, No 16 p. 50-56/junio 2011
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26

Lindgren, I., P. Humblot, D. Laskowski, and Y. Sjunnesson. "228 EFFECT OF INSULIN ON BOVINE OOCYTE MATURATION, CUMULUS CELL APOPTOSIS, AND EARLY EMBRYO DEVELOPMENT IN VITRO." Reproduction, Fertility and Development 27, no. 1 (2015): 203. http://dx.doi.org/10.1071/rdv27n1ab228.

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Dairy cow fertility has decreased during the last decades, and much evidence indicates that metabolic disorders are an important part of this decline. Insulin is a key factor in the metabolic challenge during the transition period that coincides with the oocyte maturation and may therefore have an impact on the early embryo development. The aim of this study was to test the effect of insulin during oocyte maturation on early embryo development by adding insulin during the oocyte maturation in vitro. In this study, abattoir-derived bovine ovaries were used and cumulus-oocyte complexes (n = 991) were in vitro matured for 22 h according to standard protocols. Insulin was added during maturation in vitro as follows: H (10 µg mL–1 of insulin), L (0.1 µg mL–1 of insulin), or Z (0 µg mL–1 of insulin). After maturation, oocytes were removed and fixed in paraformaldehyde before staining. Click-it TUNEL assay (Invitrogen, Stockholm, Sweden) was used for apoptotic staining and DRAQ5 (BioNordika, Stockholm, Sweden) for nuclear staining (n = 132). Cumulus-oocyte complexes were evaluated using laser scanning confocal microscope (Zeiss LSM 510, Zeiss, Oberkochen, Germany). Five levels of scans were used to assess oocyte maturation (MII stage) and apoptosis. Because of incomplete penetration of the TUNEL stain (3–5 layers of cumulus cells), only the outer 2 layers of the cumulus complex were investigated regarding apoptosis. Apoptotic index was calculated as apoptotic cells/total cells visualised. Remaining oocytes were fertilized and cultured in vitro until Day 8. Day 7 and Day 8 blastocyst formation was assessed as well as blastocyst stage and grade. Effect of insulin treatment on variables was analysed by ANOVA following arc sin √p transformation. Post-ANOVA comparisons between H+L group v. Z were performed by using the contrast option under GLM (Scheffé test). Results are presented as least squares means ± s.e. P-values ≤ 0.05 were considered as statistically significant. Insulin treatment during oocyte maturation in vitro had no significant effect on oocyte nuclear maturation or apoptotic index of the cumulus cells (Z: 0.052 ± 0.025, L: 0.039 ± 0.016, H: 0.077 ± 0.044, P > 0.05). No effect was seen on cleavage rates (Z: 0.85 ± 0.02, L: 0.85 ± 0.02, H: 0.89 ± 0.03, P > 0.05), but insulin treatment significantly decreased Day 7 rates from fertilized oocytes (Z: 0.19 ± 0.02, L: 0.14 ± 0.02, H: 0.12 ± 0.02, P < 0.05). This study also showed a significantly retarded developmental stage and decreased grade of blastocysts in insulin-treated groups taken together when compared with the control group (P < 0.05). In this study, no effect of insulin supplementation during in vitro maturation was seen on bovine oocyte maturation and apoptosis of cumulus cells, but blastocyst formation and development were negatively affected. Further studies are needed for understanding the relationship between the addition of insulin during maturation in vitro and impaired blastocyst formation. Insulin is a common supplement in the first phase of the first in vitro maturation medium for pig oocytes and is believed to have a beneficial effect on this species.Funding was received from Stiftelsen Nils Lagerlöfs Fond H12–0051-NLA.
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Panula, Sarita, Magdalena Kurek, Pankaj Kumar, Halima Albalushi, Sara Padrell Sánchez, Pauliina Damdimopoulou, Jan I. Olofsson, Outi Hovatta, Fredrik Lanner, and Jan-Bernd Stukenborg. "Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells." Human Reproduction 34, no. 11 (November 1, 2019): 2297–310. http://dx.doi.org/10.1093/humrep/dez134.

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Abstract STUDY QUESTION Does the X chromosome inactivation (XCI) of Klinefelter syndrome (KS)-derived human induced pluripotent stem cells (hiPSCs) correspond to female human pluripotent stem cells (hPSCs) and reflect the KS genotype? SUMMARY ANSWER Our results demonstrate for the first time that KS-derived hiPSCs show similar XCI behavior to female hPSCs in culture and show biological relevance to KS genotype-related clinical features. WHAT IS KNOWN ALREADY So far, assessment of XCI of KS-derived hiPSCs was based on H3K27me3 staining and X-inactive specific transcript gene expression disregarding the at least three XCI states (XaXi with XIST coating, XaXi lacking XIST coating, and XaXe (partially eroded XCI)) that female hPSCs display in culture. STUDY DESIGN, SIZE, DURATION The study used hiPSC lines generated from two azoospermic patients with KS and included two healthy male (HM) and one healthy female donor. PARTICIPANTS/MATERIALS, SETTING, METHODS In this study, we derived hiPSCs by reprograming fibroblasts with episomal plasmids and applying laminin 521 as culture substrate. hiPSCs were characterized by karyotyping, immunocytochemistry, immunohistochemistry, quantitative PCR, teratoma formation, and embryoid body differentiation. XCI and KS hiPSC relevance were assessed by whole genome transcriptomics analysis and immunocytochemistry plus FISH of KS, HM and female fibroblast, and their hiPSC derivatives. MAIN RESULTS AND THE ROLE OF CHANCE Applying whole genome transcriptomics analysis, we could identify differentially expressed genes (DEGs) between KS and HM donors with enrichment in gene ontology terms associated with fertility, cardiovascular development, ossification, and brain development, all associated with KS genotype-related clinical features. Furthermore, XCI analysis based on transcriptomics data, RNA FISH, and H3K27me3 staining revealed variable XCI states of KS hiPSCs similar to female hiPSCs, showing either normal (XaXi) or eroded (XaXe) XCI. KS hiPSCs with normal XCI showed nevertheless upregulated X-linked genes involved in nervous system development as well as synaptic transmission, supporting the potential use of KS-derived hiPSCs as an in vitro model for KS. LIMITATIONS, REASONS FOR CAUTION Detailed clinical information for patients included in this study was not available. Although a correlation between DEGs and the KS genotype could be observed, the biological relevance of these cells has to be confirmed with further experiments. In addition, karyotype analysis for two hiPSC lines was performed at passage 12 but not repeated at a later passage. Nevertheless, since all XCI experiments for those lines were performed between passage 11 and 15 the authors expect no karyotypic changes for those experiments. WIDER IMPLICATIONS OF THE FINDINGS As KS patients have variable clinical phenotypes that are influenced by the grade of aneuploidy, mosaicism, origin of the X chromosome, and XCI ‘escapee’ genes, which vary not only among individuals but also among different tissues within the same individual, differentiated KS hiPSCs could be used for a better understanding of KS pathogenesis. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by grants from the Knut and Alice Wallenberg Foundation (2016.0121 and 2015.0096), Ming Wai Lau Centre for Reparative Medicine (2-343/2016), Ragnar Söderberg Foundation (M67/13), Swedish Research Council (2013-32485-100360-69), the Centre for Innovative Medicine (2–388/2016–40), Kronprinsessan Lovisas Förening För Barnasjukvård/Stiftelsen Axel Tielmans Minnesfond, Samariten Foundation, Jonasson Center at the Royal Institute of Technology, Sweden, and Initial Training Network Marie Curie Program ‘Growsperm’ (EU-FP7-PEOPLE-2013-ITN 603568). The authors declare no conflicts of interest.
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28

Marklund, Anna, Sandra Eloranta, Ida Wikander, Margareta Laczna Kitlinski, Mikael Lood, Elizabeth Nedstrand, Ann Thurin-Kjellberg, Pu Zhang, Jonas Bergh, and Kenny A. Rodriguez-Wallberg. "Efficacy and safety of controlled ovarian stimulation using GnRH antagonist protocols for emergency fertility preservation in young women with breast cancer—a prospective nationwide Swedish multicenter study." Human Reproduction 35, no. 4 (April 2020): 929–38. http://dx.doi.org/10.1093/humrep/deaa029.

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Abstract STUDY QUESTION How efficacious and safe are the current approaches to controlled ovarian stimulation (COS) aimed at fertility preservation (FP) in women with breast cancer (BC)? SUMMARY ANSWER In women with BC undergoing COS aiming at egg/embryo cryopreservation, letrozole-based protocols and those randomly started were equally effective compared with conventional COS, and the overall survival was similar between the women that proceeded to FP and those who did not. WHAT IS KNOWN ALREADY Cryopreservation of oocytes and embryos is an established method for FP in women with BC. Recent improvements to COS protocols include concomitant use of letrozole, random-cycle start day of stimulation and the use of GnRHa for the egg maturation trigger. To date, limited sample size of the available studies has not allowed investigation of differences in the efficacy of the different approaches to COS for FP in this patient population. STUDY DESIGN, SIZE, DURATION A prospective multicenter study with national coverage including 610 women with BC counseled between 1 January 1995 and 30 June 2017 at six Swedish FP regional programs. PARTICIPANTS/MATERIALS, SETTING, METHODS After counseling, 401 women elected to undergo COS. Treatments differed in the use or not of concomitant letrozole, a conventional or random-cycle day COS initiation and the use of hCG versus GnRHa trigger for oocyte maturation. Numbers of cryopreserved oocytes and embryos were defined as primary outcome. Pregnancy attempts, reproductive outcomes and long-term survival, investigated by the linking of individuals of the cohort to the total population register of the Swedish Tax Agency (up to 25 November 2018), were evaluated. MAIN RESULTS AND THE ROLE OF CHANCE Using letrozole or not resulted in similar numbers of oocytes and embryos cryopreserved (meanoocytes = 9.7 versus 10 and meanembryos 4.0 versus 5.3, respectively), similar to COS with random versus conventional start (meanoocytes 9.0 versus 10.6 and meanembryos 4.8 versus 4.8). In COS with letrozole, a GnRHa trigger was associated with a higher number of oocytes retrieved (P &lt; 0.05) and embryos cryopreserved (P &lt; 0.005), compared with conventional hCG trigger. Of 99 women who returned to fertility clinics after cancer treatment, 32 proceeded to thawing of oocytes or embryos and 10 of them had live births. The all-cause survival between the women that underwent COS and those who did not was similar and did not differ between the two groups. LIMITATIONS, REASONS FOR CAUTION Data on tumor characteristics and estrogen receptor (ER) status were not known for all women at the time of FP counseling and planning of COS, thus protocols with letrozole have been used for both estrogen-sensitive and non-estrogen-sensitive BC. For the same reason, subsequent adjustment for ERs in the BC or tumor characteristics as potential confounders were not performed as these parameters were not available and did not influence the provision of FP through COS. WIDER IMPLICATIONS OF THE FINDINGS The results of our study support the premise that recently introduced potential improvements to COS protocols for FP in women with BC are efficacious and safe. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by research grants from the Swedish Cancer Society, the Stockholm County Council, the Percy Falk Stiftelsen, Radiumhemmets Forskningsfonder, The Swedish Breast Cancer Association and Karolinska Institutet to K.A.R.W. J.B. reports grants from Amgen, AstraZeneca, Pfizer, Roche, Sanofi-Aventis and Merck, outside the submitted work, and payment from UpToDate to Asklepios Medicine HB for a chapter on BC prediction and prognostication. All the other authors have no competing interests to report.
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van Pelt, Ans M. M., Dirk G. de Rooij, Bart van der Burg, Paul T. van der Saag, Jan-Åke Gustafsson, and George G. J. M. Kuiper. "Ontogeny of Estrogen Receptor-β Expression in Rat Testis**This work was supported by grants from the Swedish Medical Research Council (MFR K98–04P-12596–01A) and the Loo och Hans Ostermans Stiftelse (to G.G.J.M.K.) and a grant from the European Union (EU-PL95–1223; to B.v.d.B., P.T.v.d.S., and J.-Å.G.)." Endocrinology 140, no. 1 (January 1, 1999): 478–83. http://dx.doi.org/10.1210/endo.140.1.6438.

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Horuluoglu, B., A. S. Galindo-Feria, K. Chemin, G. Kozhukh, A. Dubnovitsky, V. Malmström, and I. E. Lundberg. "POS0008 IDENTIFICATION AND CHARACTERIZATION OF HISRS+ CD4+ T CELLS PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 206.2–206. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3583.

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Background:Idiopathic inflammatory myopathies (IIM) also known as myositis, are rare chronic autoimmune disorders which are represented by muscle weakness and extra-muscular features such as skin rash, interstitial lung disease (ILD) and arthritis. One of the most common autoantibodies in myositis, with a prevalence of 25-35%, is the anti Jo-1 autoantibodies, targeting the histidyl-transfer RNA synthetase (HisRS). Although the exact mechanism of how these antibodies are developed is unknown, we have previously shown that upon stimulation of both peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage fluid cells (BALF) with HisRS protein, CD4+ T cells were activated and produced inflammatory cytokines. Hitherto the presence of antigen specific autoreactive T cells has not been established in myositis, however previous studies by our group showed a strong indication of their presence with a reactivity to a specific HisRS peptide.Objectives:The main aim of this project is to detect and characterize HisRS specific CD4+T cells using HLA Class II tetramers. HLA Class II tetramers allow the detection of rare antigen specific CD4+ T cells and are widely used in studies of immunity, vaccine development, allergy monitoring and in autoimmunity. These cells are of specific interest to understand autoimmunity and to develop new therapies in autoimmune diseasesMethods:HLA-DRB1*03:01 monomers with selected tetanus and HisRS peptides were in-house in E.coli system. The peptides of interest were attached to the N-terminus of the HLA b-chain via a flexible peptide linker. HLA-tetramers were assembled using a commercial fluorescently labeled streptavidin. The efficacy of the peptide-HLA tetramers was validated by stimulating PBMCs from HLA-matched healthy controls with tetanus peptide. The drequency of tetanus specific CD4+ T cells were detected at different time points (6,13 and 21 days) from the cultures using tetanus peptides bound HLA-DRB1*0301 tetramers. The presence of tetanus specific T cells was confirmed by the secretion of significantly higher IFNg levels upon re-stimulation of cells with tetanus peptide. The same protocol is applied for the HisRS-peptide tetramers. Peripheral blood cells are analysed from anti-Jo1+ and HLA-DRB1*0301 positive patients with IIM.Results:Applying this method, our preliminary findings demonstrate the presence of HisRS+CD4+ T cells in peripheral blood from Jo-1+ patients (n=3) using HisRS tetramers following stimulation with the respective peptide. We are now including more patient samples to confirm our findings, and further characterize their phenotype and functionalities by flow cytometry and ELISA/fluorospot assaysConclusion:Myositis is a rare and chronic autoimmune disorder, with no currently available cure. Previous studies indicate the importance of T cells in this disease. However, the phenotype, functionality and role of these cells in the disease pathogenesis has not been fully established. Characterization of this autoreactive T-cell population will help us enhance our understanding of the disease pathogenesis and thus to develop better treatment options.Acknowledgements:This work has been supported by grants from Karolinska Instiutet Resarch Foundation, Professor Nanna Svartz Stiftelse, Hjärt-Lung Fonden and Vetenskapsrådet in Sweden.Disclosure of Interests:Begum Horuluoglu: None declared, Angeles Shunashy Galindo-Feria: None declared, Karine Chemin: None declared, Genadiy Kozhukh: None declared, Anatoly Dubnovitsky: None declared, Vivianne Malmström: None declared, Ingrid E. Lundberg Consultant of: Consulting fees from Corbus Pharmaceuticals, Ind, Grant/research support from: Research grants from Bristol Myers Squibb and Astra Zeneca.
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Mollah, Sabur, and Eva Liljeblom. "Governance and bank characteristics in the credit and sovereign debt crises – the impact of CEO power11We are grateful to the Editor, Prof. Iftekhar Hasan and three anonymous referees for valuable comments. We acknowledge financial support from Jan Wallanders och Tom Hedelius Stiftelse, Handelsbanken, Sweden (Project ID: P2010-0144: 1). We are especially grateful to Hafiz Hoque for his valuable comments on an early draft of the study in which he also was a co-author. The paper has undergone major changes since then and Hafiz Hoque chose not to be a co-author of this draft. We are also thankful to Omar Sikder, Alovaddin Kalonov, Sharifur Rahman, Iffat Ara, Rokonuzzaman, and other research assistants for their help in data collection. The authors are responsible for any remaining errors." Journal of Financial Stability 27 (December 2016): 59–73. http://dx.doi.org/10.1016/j.jfs.2016.09.003.

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Coles, John. "European rock art: arti-facts and fancies - Åsa C. Fredell, Kristian Kristiansen & Felipe Criado Boado. Representations and communications: creating an archaeological matrix of late prehistoric rock art. xx+158 pages, 53 illustrations. 2010. Oxford & Oakville (CT): Oxbow; 978-1-84217-397-8 paperback £25. - L. Bengtsson (ed.). Arkeologisk Rapport 7, Vitlycke Museum. Stiftelsen för dokumentation av Bohusläns hällristningar: Tossene socken [Foundations for the documentation of Bohuslän's rock carvings: parish of Tossene]. 120 pages & 190 pages of illustrations. 2009. Tanum: Vitlycke Museum; ISSN 1401-9078 paperback (see http://www.hallristning.se/rapport.htm). - Gerhard Milstreu & Henning Prøhl (ed.). Documentation and registration of rock art in Tanum / Dokumentation och registrering av hällristningar i Tanum. No. 3: Kalleby, Finntorp, Ryk. 181 pages, numerous colour & b&w illustrations, CD-ROM. 2009. Tanum: Hällristningsmuseum Underslös / Scandinavian Society for Prehistoric Art; 978-91-85245-40-2 paperback (see http://www.rockartscandinavia.se/pdf/DOC3%20lille%20GM-kopi.pdf)." Antiquity 85, no. 327 (February 2011): 284–87. http://dx.doi.org/10.1017/s0003598x00067636.

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Valestrand, Halldis. "Kjønnsblind regional omstilling." Septentrio Conference Series, no. 3 (November 12, 2019). http://dx.doi.org/10.7557/5.5081.

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Store endringer har skjedd de senere årene i norske kommuner- og fylkeskommuner, ettersom de har fått stadig mer ansvar for egen samfunnsutvikling. Målsetningen er nesten uten unntak formulert i retning av å bli ‘attraktive (lokal)samfunn i vekst’. Ofte handler det om å sette i gang utredninger og planer for større eller mindre innsatser i alt fra infrastruktur til omstillingsprosjekter som involverer hele samfunnet og som kan bli ganske omfattende og kostnadskrevende. Politikerne og andre ansvarlige (kan) stilles til ansvar for resultatene og det er krav om evalueringer og dokumentasjon i hele dette systemet. Dette betyr et krav om at kunnskapsgrunnlaget må være best mulig for at de rette avgjørelser kan tas. Det være seg å produsere faktagrunnlag, utredninger, søknader om statlige midler, såkalte konsekvensanalyser (krav i Plan og bygningsloven bl.a), altså samfunnsdiagnoser av ulike slag. I tråd med nyliberaliseringen i norsk politikk og administrasjon er det blitt stadig vanligere å ‘outsource’ dette arbeidet til eksterne aktører, private rådgivere, stiftelser eller større byråer (type Multiconsult, Norconsult, COWI, osv), etter en bestiller-utførermodell. Ofte omtales disse aktørene som kompetanseleverandører, og de ‘leverer’ etter bestilling. Kunnskapen om et samfunn er altså en vare. Etter å ha lest meg gjennom en del materiale i forbindelse med omstillingsprosesser i norske kommuner er det spesielt to forhold som har slått meg. Det første er at dette ‘feltet’ synes å være fredet for kritisk samfunnsanalyse, det antas tilsynelatende å være utenfor de politiske prosessene. Det andre, som jeg vil sette søkelys på, er om de også oppfattes og oppfatter seg selv, som kjønnsnøytrale, det være seg i sine leveranser, språk og rådgiving. Her er det jo snakk om offentlige penger og politiske prosesser, så hvem ser etter kjønnsbalanse og likestillingsperspektiv? Her er det noe som har gått under radaren når det gjelder både politikk og analyser.
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Nielsen, Jan Ahtola. "Nordisk forår. Stiftelsen af foreningen Norden." Fund og Forskning i Det Kongelige Biblioteks Samlinger 45 (May 15, 2014). http://dx.doi.org/10.7146/fof.v45i0.41187.

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At the outbreak of the First World War, relations between the Scandinavian countries were not exactly cordial. The dissolution of the Swedish-Norwegian Union in 1905 had created deep divisions in the Nordic region, and only during the War did Nordic cooperation regain its place of honour. The authorities were engaging in diplomatic and trade cooperation to try to ease the huge difficulties which the war between the Great Powers was causing. This stimulated Nordically minded opinion, which was not blind to the opportunities created by the outside pressure. The idea of a Nordic association for strengthening Nordic cooperation was launched by Danish ophthalmologist C.F. Heerfordt, but differences in opinion among the Danish Nordicists on how best to tackle the matter restricted the numbers taking up membership in the association which Heerfordt was instrumental in founding in Denmark in June 1917. Through his active lobbying in Sweden, Heerfordt provided the impulse for the foundation of a corresponding Swedish association, but several of the leading Swedish Nordicists held aloof from the ophthalmologist’s advances, partly owing to his federal ambitions for Nordic cooperation. In April 1918, instead of entering a partnership with the Danish association, the Swedish Nordicists approached a small group of prominent Danish Nordicists under the leadership of the influential conservative politician and industrialist Alexander Foss, and it was this small group which was chiefly responsible for founding the Danish “Norden” Association in April 1919. Heerfordt and his supporters had given their approval for the new initiative, but were unable to give it unconditional backing. The Swedes had proposed that the associations should work for political and economic rapprochement between the Nordic countries, but this met fierce Norwegian resistance, and the aim was changed to the mere strengthening of cultural and economic cooperation.
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Jørgensen, Per. "Eugen Stahl Schmidt og DIF - Dansk Idræts-Forbunds baggrund, dannelse og etablering 1892-1925." Forum for Idræt 9 (August 18, 1993). http://dx.doi.org/10.7146/ffi.v9i0.31825.

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Et historisk tilbageblik på DIF's etablering i anledningen af organisationens 100 års fødselsdag i 1996. Artiklen indeholder en biografi af Eugene Stahl Schmidt, som var en af drivkrafterne bag DIF's stiftelse.
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Magnusson, Jan. "Den korporativa hivpolitiken." Socialvetenskaplig tidskrift 5, no. 2-3 (February 4, 2016). http://dx.doi.org/10.3384/svt.1998.5.2-3.2921.

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Ett utmärkande drag i svensk politik är det samarbete mellan staten och frivilliga organisationer som kallas för den korporativa modellen. I denna artikel diskuteras Folkhälsoinstitutets, RFSLs, RFSUs och stiftelsen Noaks ark/Röda korsets korporativa samarbete om hivförebyggande insatser, dess konsekvenser för organisationerna och den hivförebyggande politikens praktiska utformning.
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Fredriksson, T., M. Stridh, L. Friberg, and E. Svennberg. "Prognostic implications of supraventricular ectopy." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0687.

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Abstract Background According to consensus atrial fibrillation (AF) is an irregular heart rhythm with absence of p-waves, lasting for at least 30 seconds. However, AF is most likely a continuous disease ranging from occasional bursts of AF-like activity to permanent AF, rather than a dichotomous condition. Regardless, the 30-second AF definition leaves cardiologists without clear guidelines on how to manage patients with shorter episodes of seemingly atrial fibrillation-like activity and/or an abundance of supraventricular ectopic beats. Purpose The aim of this study was to establish the prevalence and prognostic implication of frequent supraventricular ectopic beats, isolated, in bi- or trigeminy, and supraventricular tachycardias with different characteristics. Methods In the STROKESTOP I mass-screening study for AF in 75- and 76-year olds in Sweden, 7173 participants did 30-second intermittent ECG twice daily for two weeks. ECG-recordings from STROKESTOP I were re-evaluated using an automated algorithm to detect individuals with frequent supraventricular ectopic beats or runs. Detected episodes were manually re-examined to confirm the findings. The primary endpoint was atrial fibrillation as ascertained from the nationwide Swedish Patient register. Secondary endpoints were stroke and death. Median follow-up was 4.2 (3.8–4.4) years. Results Of the 6100 examined participants 85% were free of significant supraventricular arrhythmia. Frequent supraventricular ectopic beats were the most common arrhythmia, n=709 (11.6%), and irregular SVTs were more common than regular SVTs. During follow-up 387 participants developed AF, 161 had a stroke event and there were 354 deaths. Individuals with the most AF-like SVT, irregular and lacking p-waves, n=97 (1.6%), had the highest risk of developing AF (hazard ratio 4.3 (95% confidence interval 2.7–6.8), Figure 1. They also had an increased risk of death, 2.0 (1.1–3.8). We found no significant increase in stroke risk. Conclusion Progression of atrial arrhythmias from supraventricular ectopic beats to more organized arrhythmic episodes are associated with development of AF. Extended screening for AF should be considered in individuals with frequent supraventricular activity, especially in those with supraventricular tachycardias with AF characteristics. Figure 1. Kaplan-Meier curve showing primary end-point event rate (atrial fibrillation) in participants with different arrhythmias. Funding Acknowledgement Type of funding source: Private grant(s) and/or Sponsorship. Main funding source(s): This study was supported by Stiftelsen Hjärtat, Boehringer Ingelheim, The Swedish Heart and Lung Association, Capio Forskningsstiftelse and Åke Wibergs Stiftelse. STROKESTOP I was founded by Stockholm County Council, the Swedish Heart & Lung Foundation, King Gustav V and Queen Victoria's Freemasons' Foundation, the Klebergska Foundation, the Tornspiran Foundation, the Scientific Council of Halland Region, the Southern Regional Healthcare Committee, the Swedish Stroke Fund, Boehringer-Ingelheim, Bayer and Pfizer. Emma Svennberg is supported by the Stockholm County Council (Clinical postdoctorial appointment) and has received research funding from the Swedish Society of Medicine.
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Arvanitis, P., A. K. Johansson, M. Frick, H. Malmborg, S. Gerovasileiou, E. M. Larsson, and C. Blomstrom Lundqvist. "Timing and degree of left atrial stunning and reverse functional remodeling following electrical cardioversion in patients with recent onset atrial fibrillation." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0465.

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Abstract Background Atrial fibrillation (AF) results in left atrial electrical, structural and functional remodeling. Restoration of sinus rhythm hallmarks the beginning of reverse remodeling, the extent of which may depend on the type of AF. Purpose The aim of the study was to assess resumption of left atrial function after electric cardioversion in patients with recent onset AF and to explore the association between reverse remodeling and the type of atrial fibrillation. Methods Patients with AF duration &lt;48 hours were prospectively included. Trans-thoracic echocardiography was performed prior, immediately after (2–4 hours) and 7–10 days following CV. Left atrial volume index (LAVI), left atrial global longitudinal strain during reservoir (LAGLS-res), conduit (LAGLS-cond) and contractile (LAGLS-contr) phases, left atrial ejection fraction (LAEF) and left ventricular ejection fraction (LVEF) were measured. Results Forty-three patients (84% males) aged 55±9.6 years, (mean±SD), with median CHA2DS2-VASc score 1 (interquartile range 0–1) were included. Repeated measure analysis of variance revealed a statistically significant overall change for LAGLS-res F(2,78)=55.4, p&lt;0,001, LAGLS-cond F(2,78)=23.3, p&lt;0,001, LAGLS-contr F(2,78)=39.7, p&lt;0,001, LAEF F(2,80)=28.5, p&lt;0.001 and LVEF F(2,80)=8.4, p&lt;0.001. At 7–10 days, LAGLS-contr 12±4%, LAEF 53±9% and LVEF 60±6 (mean±SD) return within normal reference intervals. Notably left atrial recovery seems to precede left ventricular recovery. No statistical significant interaction with the type of atrial fibrillation could be shown. Conclusion Left atrial functional reverse remodeling occurs within ten days after successful electric cardioversion of patients with recent onset atrial fibrillation. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Swedish Heart-Lung Foundation, Correvio International Sárl (Geneva Switzerland), Selanders Stiftelse
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Arvanitis, P., A. K. Johansson, M. Frick, H. Malmborg, E. M. Larsson, and C. Blomstrom Lundqvist. "Activation of inflammatory/coagulation system following electrical cardioversion of patient with recent onset atrial fibrillation: an explorative study of the relation to white matter hyperintensities." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0464.

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Abstract Background White matter hyperintensities (WMH), assessed using Fazekas scale, are more prevalent in patients with atrial fibrillation (AF), although its pathophysiologic mechanism(s) is unclear. Purpose The study objective was to explore the association between cardiac, inflammatory and coagulation biomarkers and white matter hyperintensities in anticoagulant-naïve patients following electrical cardioversion (CV) of recent onset AF. Methods Patients with AF duration &lt;48 hours were prospectively included. Brain magnetic resonance imaging (MRI), C-reactive protein (CRP), high-sensitivity troponin T (hs-TNT), NT-proBNP, Interleukin 6, P-selectin, D-dimer, prothrombin fragment 1+2, von Willebrand factor Ag, coagulation factor VIII C and fibrinogen, were obtained sequentially prior, after (2–4 hours) and 7–10 days following CV. Repeated measure analysis of variance was performed. Results Forty-three patients (84% males), aged 55±9.6 years, (mean±SD) with median CHA2DS2-VASc score 1 (interquartile range 0–1) were included. Sequential MRI showed no new brain lesions after CV, while WMH were present at baseline in 21/43 (49%) patients. Repeated measure analysis of variance revealed a statistically significant overall change for hs-TNT: F(2,84)=6.056, p=0.03, NT-proBNP: F(2,84)=106.02, p&lt;0.001, P-selectin: F(2,84)=8.69, p&lt;0.001 and vWF:Ag: F(2,84)=4.078, p=0.02. CRP, IL-6, coagulation factor VIII-C and fibrinogen showed the same pattern, however none reached statistical significance. Patients with WMH had persistent higher values for CRP, hs-TNT, D-dimer, prothrombin fragment 1+2 and fibrinogen prior and after CV, as values at 7–10 days coincided; however, statistical interaction was not significant. Conclusion Transient activation of inflammatory and coagulation systems during atrial fibrillation subsides within 7–10 days after electric cardioversion of recent onset atrial fibrillation. A tendency of higher degree of activation during atrial fibrillation was observed in patients with white matter hyperintensities. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Swedish Heart-Lung Foundation, Swedish Research Council, Correvio International Sárl (Geneva Switzerland), Selanders Stiftelse
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Nordstrom, J., P. Magnusson, H. Harms, M. Lubberink, S. Morner, and J. Sorensen. "P3361Pathophysiology measured with positron emission tomography is equally impaired in hypertrophic and non-hypertrophic regions in hypertrophic cardiomyopathy." European Heart Journal 40, Supplement_1 (October 1, 2019). http://dx.doi.org/10.1093/eurheartj/ehz745.0237.

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Abstract Background Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with regard to clinical manifestations. It is characterized by an asymmetric pattern of hypertrophy of the left ventricle. However, less is known about pathophysiological distribution of the abnormalities. Positron emission tomography (PET) provides quantitative assessment of myocardial blood flow (MBF), oxidative metabolism, and sympathetic innervation using the following tracers: 15O-water, 11C-acetate, and 11C-HED. Purpose The purpose of the present study was to investigate if physiological parameters measured with PET are more impaired in hypertrophic regions compared to non-hypertrophic regions. Methods We examined 25 HCM patients using a Discovery MI PET/CT with 15O-water, 11C-acetate, and 11C-HED. Wall thickness (WT) was calculated from the 11C-acetate scan for basal and mid segments (n=12) in the 17-segment model and hypertrophic regions were defined as segments >15 mm. 15O-water PET was performed during rest and adenosine induced stress. Quantification of MBF, oxygen consumption (MVO2) and retention index of 11C-HED (RIHED) was done in aQuant software. Comparison of parameters in hypertrophic regions to non-hypertrophic regions was done using Mann-Whitney U- test and Bland-Altman analysis with repeatability coefficient defined as 2 times the standard-deviation of differences. Results One patient had all segments >15mm and one patient had all segments <15mm and were therefore excluded from analysis. WT was 18.2±1.9 mm in hypertrophic regions and 12.2±1.5 mm in non-hypertrophic regions. None of the PET-parameters showed a significant difference between hypertrophic and non-hypertrophic regions, see table 1. Table 1 MBFREST MBFSTRESS MVO2 RIHED Hypertrophic segments (mm) 0.70±0.20 1.74±0.92 0.092±0.026 0.12±0.037 Non-hypertrophic segments (mm) 0.68±0.18 1.71±0.87 0.094±0.025 0.12±0.036 p-value 0.767 0.851 0.956 0.684 Repeatability coefficient (%) 25.4 35.4 13.3 16.2 Mean ± standard deviation for PET-parameters in hypertrophic and non-hypertrophic segments. Relative repeatability coefficient (%) between regions and p-value for Mann-Whitney U-test. Conclusion Pathophysiology in terms of myocardial blood flow at rest and stress, oxygen consumption and sympathetic innervation are not significantly different in hypertrophic segments compared to non-hypertrophic segments in patients with HCM. Thus, the disease is not confined to hypertrophied areas but spread throughout the left ventricle. Acknowledgement/Funding Selanders stiftelse, Regionala forskningsrådet
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Arvanitis, P., A. K. Johansson, M. Frick, H. Malmborg, E. M. Larsson, and C. Blomstrom Lundqvist. "P1080Magnetic resonance imaging after electrical cardioversion of recent-onset atrial fibrillation in anticoagulant-naive patients - a study exploring clinically silent cerebral lesions." EP Europace 22, Supplement_1 (June 1, 2020). http://dx.doi.org/10.1093/europace/euaa162.377.

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Abstract Funding Acknowledgements Unrestricted grants from the Swedish Heart-Lung Foundation, the Swedish Research Council, Correvio International Sárl (CH) and Selanders stiftelse Background Patients with atrial fibrillation (AF) have a high incidence of cognitive impairment, which may be related to clinically silent microembolism causing cerebral infarctions. Purpose To explore the occurrence and timing of silent brain lesions following electrical cardioversion (CV) of recent onset AF in anticoagulant-naïve patients and to further study related effects on cognitive function and biomarkers of cerebral damage, S100b. Methods Patients with AF duration &lt; 48 hours were prospectively included. Brain magnetic resonance imaging (MRI) and S100b, were obtained prior, after and 7-10 days following CV. Trail making tests (TMT-A and TMT-B) and their difference, ΔΤΜΤ, were assessed prior to CV, 7-10 days and 30 days after CV. Results Forty-three patients (84% males) with mean CHA2DS2-VASc score 0.6 ± 0.7 were included. Sequential MRI, including diffusion weighted scans, showed no new brain lesions after CV. Chronic white matter hyperintensities (WMH) were present at baseline in 21/43 (49%) patients. By partitioning the study population into four major groups according to the extend of WMH (Fazekas score 0 or ≥ 1) and the presence or absence of TE risk factors (CHA2DS2-VASc score 0 or ≥ 1), the TE risk as defined by CHA2DS2-VASc score ≥ 1, was associated with a higher incidence of WMH, Pearson χ2(1,N = 43)=3.95, p = 0.047. The S100b (µg/l) levels increased significantly from baseline, (mean ± SD) 0.0472 ± 0.0182 to 0.0551 ± 0.0185 after CV, p = 0.001 and then decreased 7-10 days after CV to 0.0450 ± 0.0186, p &lt; 0.001. Subgroup analysis according to the presence of at least one TE risk factor as defined by CHA2DS2-VASc score showed that statistical significance of repeated measures ANOVA was maintained; for patients with no risk factors F (2,30)=12.59, p &lt; 0.001 and for patients with CHA2DS2-VASc score ≥1 F(2,36)=4.43, p &lt; 0.019. Consecutive TMT scores improved successively after CV, being statistically and clinically significant for TMT-B (p &lt; 0.01) and ΔΤΜΤ (p = 0.005) between 7-10 days and 30 days after CV (Reliable Change Index &gt;1.96). Conclusion New brain lesions could not be detected on MRI after CV, but the high incidence of white matter hyperintensities and the transient increase in S100b may indicate transient or minor brain damage undetectable by MRI thus heightening the need to reevaluate thromboembolic risk prior to CV even in low risk patients. Abstract Figure. S100b_TMT
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Kjekshus, H., L. Skrebelyte-Strom, V. Bakkelund, H. Arnesen, O. M. Ronning, K. Steine, and I. Seljeflot. "Biomarkers in patients with cryptogenic stroke/TIA and subclinical atrial fibrillation." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.2439.

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Abstract Background A large proportion of patients with cryptogenic stroke or transitory ischemic attack (TIA) have underlying subclinical atrial fibrillation (SCAF) detected on follow up. It is not clear whether SCAF is the underlying primary entity in the pathogenesis of stroke in these patients, or merely a marker of atrial myopathy associated with left atrial remodeling, fibrosis and inflammation. Purpose As a hypothesis generating study, we investigated a panel of selected biomarkers involved in fibrosis, inflammation, and thrombosis: growth differentiation factor 15 (GDF-15), transforming growth factor b (TGFb), galectin-3, soluble suppressor of tumorgenicity2 (sST2), von Willebrand factor (vWF), Tissue metalloprotease1 (TIMP1), Matrix metalloprotease9 (MMP9), Emmprin, Interleukin6 (IL6), C-reactive protein (CRP), Tissue factor (TF), Plasminogen activator inhibitor (PAI1), and their relation to the occurrence of SCAF during follow-up in patients after cryptogenic stroke or TIA. We hypothized that biomarker levels were increased in patients with subclinical AF. Methods 236 patients, median age 71 years (range 21–94) of which 38% were women, with their first cryptogenic stroke or TIA were included 2–4 days after the index event and followed with an Implantable Cardiac Rhythm Monitor for &gt;1 year. Echocardiography and blood sampling were performed at inclusion. ELISA methods were used. Results SCAF occurred in 84 patients (36%). Only GDF-15 was significantly increased in AF- vs no-AF patients: 1010 pg/mL (inter quartile range: 814–1416) vs 860 pg/mL (inter quartile range: 622–1197) (p=0.018), and correlated with the number of premature atrial contractions (PAC)/24h (by Holter ECG during index hospitalization) (rs=0.314, p&lt;0.001) and AF-burden during follow-up (rs=0.149, p=0.022). Furthermore, there was a significant trend across quartiles of GDF-15 for having AF, and patients in the three highest quartiles (Q2–4) compared with Q1 had an odd ratio of having AF of 2.16 (95% CI 1.10–4.25), adjusted for sex and body mass index. The significance, however, was lost when adjusting for age, which correlated significantly to GDF-15 (rs=0.283; p&lt;0.001). ROC curve analyses showed an AUC of 0.593 (0.52–0.68) for GDF-15 compared to 0.617 (0.54–0.69) for age. GDF-15 was also associated with co-morbidities such as hypertension (p&lt;0.001), diabetes (p&lt;0.001), and vascular disease (p&lt;0.001). Conclusion In patients with a cryptogenic stroke or TIA experiencing SCAF during follow up, only levels of GDF-15 were elevated and correlated with PAC/24h and AF-burden. However, GDF-15 was highly related to age and co-morbidities and did not add significantly to the prediction of AF in a multivariate analysis. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Stiftelsen Dam, Norwegian Atrial Fibrillation Research Network
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43

Kommata, V., M. I. Elshafie, M. Perez, R. Augustine, and C. Blomstrom-Lundquist. "QRS dispersion using 252-leads Body Surface Mapping (BSM) – an explorative study of a novel diagnostic tool for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0336.

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Abstract Background The diagnosis of ARVC is complex and challenging requiring multiple investigational tools, most of which include the demonstration of depolarization/conduction abnormalities, described in recent HRS consensus documents 2019. A simple and user friendly diagnostic tool is warranted. Purpose The purpose of our study was therefore to explore whether the analysis of QRS dispersion obtained from 252-leads recorded by a Body Surface Mapping (BSM) system can be used to identify ARVC patients as compared to the traditional ECG criteria including QRS dispersion measured by conventional 12 lead surface ECG. Methods 12 definite ARVC patients (10/12 with known pathogenic mutation) (Group 1) and 8 healthy family members tested negative for the family mutation served as controls (Group 0), were included. All patients underwent 12-lead ECG (50mm/sec), Signal-averaged ECG for late potentials and 252 lead BSM recordings. The QRS duration was measured in each of the 12 ECG leads manually with digital caliper. The QRS duration from the BSM leads were manually analyzed in Matlab by two observers unaware of the diagnosis. For each lead, the mean value of three randomly chosen beats was calculated. The QRS dispersion was calculated as the difference between the minimum and maximum value for both the 12 lead ECG and the BSM recordings. Results The mean age was 49,6 and 38,8 years in ARVC patients and controls, respectively. The number of males in the two groups were 8/12 and 5/8, respectively. Epsilon waves and Terminal Activation Duration (TAD) &gt;55msec were detected in 6/12 and 8/12 ARVC patients, respectively, but in no controls. Late potentials were detected in 11/12 ARVC patients and in 2 controls. The QRS duration and QTc duration was not statistically different in the two Groups. The ECG-QRS dispersion was significantly more pronounced in Group 1 (42 ms ± 15, range 20–70 ms) than in Group 0 (26 ms ± 8, range 16–36 ms) (p=0.013). The BSM-QRS dispersion was significantly longer in Group 1 (68 ms ± 17, range 29–90ms) than in Group 0 (30 ms ± 7, range 22–41ms) (p=0.001). Only one ARVC patient had a BSM-QRS dispersion &lt;50 msec, whereas none of the controls had a QRS dispersion over 50 msec (Fig. 1). Conclusion BSM-QRS dispersion, specifically using the cut off &lt;50 ms, can potentially be a more sensitive and specific method than other ECG related techniques for diagnosing ARVC patients versus non-ARVC patients. Larger patient cohorts and further studies are required to confirm our findings. Figure 1. ECG and BSM-QRS dispersion Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Selanders Stiftelse
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44

Kommata, V., M. I. Elshafie, M. Perez, R. Augustine, and C. Blomstrom-Lundquist. "The repolarization pattern of ARVC patients, healthy gene carriers and controls as analyzed with a 252-leads Body Surface Mapping Vest." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0337.

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Abstract Background Repolarization abnormalities have a central role on the diagnosis of ARVC according to recent HRS consensus document from 2019 stating that T wave inversion in the right precordial leads is a major criteria if it appears in V1-V3 or a minor criteria if it appears in only V1-V2. Purpose The aim of our study was to investigate whether repolarization patterns as recorded by a Body Surface Mapping (BSM) system consisting of a vest with 252 ECG leads, could differentiate ARVC patients and even gene carriers from normal individuals. Our hypothesis is that the method can potentially identify repolarization disturbances earlier or better than conventional 12-lead ECG. Method 12 definite ARVC patients, 20 healthy gene carriers and 8 family members who tested negative for the family mutation (controls) were included. All patients underwent 12-lead ECG, including right precordial leads (V4R) and BSM recordings. Repolarization (T-wave polarity and concordance with QRS complex vector) was analyzed qualitatively in all BSM recordings, the results of which were displayed on a color code map (fig.1). Results The mean age was 49.6, 43.6 and 38.8 years in ARVC patients, healthy gene carriers and controls, respectively. The number of males in the three groups were 8/12, 8/20 and 5/8, respectively. All 8 controls had similar repolarization patterns with negative and concordant T waves on the right back panel, and T waves that successively changed from negative concordant (green) to positive disconcordant (red) and finally positive concordant (blue) on the left front panel (pattern 1). All 12 ARVC patients had different repolarization patterns as compared to the controls. Two of these patients had no apparent repolarization changes on conventional 12 lead ECG. The pattern type 2 repolarization, as defined by same pattern as the controls at the right back panel but different pattern at the front left panel was seen in 3/12 ARVC patients. The remaining 9 ARVC patients had different repolarization patterns both on the front and on the back panel (pattern 3). Among gene carriers, 15 had a normal repolarization pattern (pattern 1) and 5 demonstrated an abnormal repolarization pattern (4 had pattern type 2 and one pattern 3) despite normal surface ECG. Conclusions Using BSM recordings, abnormal repolarization patterns can be detected in all ARVC patients, even in those without repolarization changes on conventional surface ECG. The observation that 25% of gene carriers had divergent repolarization patterns, may indicate an early stage of the disease, and be used as an early diagnostic marker of the disease. Further and larger studies are warranted to confirm these observations. Repolarisation patterns recorded by BSM Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Selanders Stiftelse
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45

Svensson, P., J. Ohm, D. Johansson, A. Discacciati, K. Hambraeus, M. Leosdottir, and T. Jernberg. "4952Level A evidence - for A-level patients only? Participants in clinical trials post myocardial infarction have higher socioeconomic status and better prognosis." European Heart Journal 40, Supplement_1 (October 1, 2019). http://dx.doi.org/10.1093/eurheartj/ehz746.0022.

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Abstract Introduction Randomized clinical trials (RCT) produce the highest level of evidence and therefore form the basis for many guidelines. Their Achilles heel is external validity which is still poorly studied. Participants in clinical trials may partly be selected on unknown mechanisms in particular regarding socioeconomic status. To what extent participants in clinical trials after myocardial infarction (MI) are representative for the overall MI population is unknown. Purpose To investigate whether participants in clinical trials after myocardial infarction differ regarding socioeconomic status (SES), risk factor profile, prior and recurrent cardiovascular disease (CVD) events. Methods A total of 34,084 patients attending follow up after myocardial infarction between 2007 and 2014 were identified in the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) out of which 3,037 had participated in a clinical trial. Information on disposable income, education level, marital status, prior CVD, risk factors and treatment were retrieved from national registers and patients were followed regarding recurrent CVD. Participants in clinical trials were compared to non-participants using logistic and Cox regression analyses. In a multivariable Cox-regression analysis adjustments were made for gender, age, inclusion-year, diabetes, LVEF, previous MI, previous stroke, prior cardiac surgery, ECG rhythm, eGFR, lipid levels, smoking status, use of ASA, use of ACE-I, use of beta-blockers, use of statins, level of education, disposable income and family status. Results Trial participants were more likely to be men (odds ratio (OR): 1.42; 95% CI: 1.29–1.55)), to be married (1.17; 1.09–1.27), to have a high income (1.58; 1.45–1.72), have a post-secondary education (>12 years) (1.33; 1.22–1.46) and less likely to be smokers (0.81; 0.72–0.90), have a reduced EF <30% (0.61; 0.46–0.80), history of previous stroke (0.79; 0.65–0.97) or MI (0.86; 0.77–0.97) compared to non-participants. The risk for recurrent CVD was lower among the participants compared to the non-participants (HR: 0.77; 95% CI: 0.67–0.88) and is illustrated in figure 1. In a fully adjusted model the lower risk remained after adjusting for age, gender, risk factors, prior disease including EF, evidence based treatments and SES (HR: 0.85; 95% CI: 0.74–0.97). Trial participation and recurrent CVD Conclusion Participants in clinical trials after MI constitute a highly selected group with higher SES, a more favourable risk profile and a better overall prognosis. The lower risk after full adjustments imply that additional selection bias exists. The external validity of post MI- trials in general can thus be questioned. To what extent results from clinical trials apply to the overall post MI population should be carefully scrutinized. Real world registry data are important. Acknowledgement/Funding Familjen Janne Elgqvists Stiftelse
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46

Skrebelyte-Strom, L., K. Steine, O. M. Ronning, F. Dahl, and H. Kjekshus. "PRediction and detection of Occult Atrial fibrillation in patients after acute Cryptogenic stroke and Transient Ischemic Attack (PROACTIA)." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.2433.

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Abstract Background Studies with implantable cardiac rhythm monitors (ICRM) have shown that a 1/3 of patients with cryptogenic stroke/transitory ischemic attack (TIA) have episodes of subclinical atrial fibrillation (SCAF) as one of the potential risk factor for cerebral embolism. However, ICRM are costly and resource demanding. Purpose The PROACTIA study seeks to test a pre-specified scoring system to assess individual risk of SCAF in order to offer tailored therapy to patients after cryptogenic stroke/TIA. Methods Patients admitted with first time cryptogenic stroke or TIA were eligible for the study and underwent blood sampling, cerebral CT/MRI, carotid Doppler ultrasound, ECG, 24h-HolterECG, transthoracic transesophageal echocardiography, registration of medical history and implantation of ICRM during the index hospitalization The scoring system was composed of variables that have previously been found associated with AF occurrence: CHA2DS2-VASc, P-wave duration (P-dur), premature atrial contractions (PAC)/24h, supraventricular runs (SVR)/24h, left atrial end-systolic volume index (LAVI), and the biomarkers TnT, NT-proBNP and D-dimer. Data are presented as median (inter quartile range). Results Within 25 months, 434 patients screened and 251 patients were included in the present study and had an ICRM implanted. Eleven patients were later excluded yielding a study cohort of 176 patients with cerebral infarction and 61 with TIA that were followed for 833 (633–1028) days. AF was detected in 36%. It took 113 (25–336) days to detect AF, and 5 (2–14) days from AF-detection to initiation of NOAC. All variables were significantly increased in AF patients: no-AF vs AF: CHADS-VASC: 4 (3–5) vs 5 (4–6)*, LAVI mL/m2: 35 (28–40) vs 40 (35–50)**, PAC/24h: 69 (29–211) vs 347 (59–1917)**, SVR / 24-h: 1 (0–3) vs 3 (1–17)**, P-dur ms: 100 (100–120) vs 120 (100–120)**, D-dimer mg/L: 0,3 (0,2–0,6) vs 0,5 (0,3–0,9)**, TnT ng/L: 10 (7–16) vs 15 (9–27)**, NT-proBNP ng/L: 103 (49–283) vs 245 (102–774)**. *p&lt;0.01, **p&lt;0.001. Multivariate analysis yielded the following model: −8.524 + 0.057*LAVI (p&lt;0.001) + 0.035*P-dur (p&lt;0.001) + 0.873*LogPAC/24h (p&lt;0.001). ROC analysis using leave-one-out cross validation: AUC=0.77. Applying the model to our population, it would identify a high-risk group (&gt;80% true positive) consisting of 17 true positive and 4 false positive, and a low-risk group (&lt;5% false negative) consisting of 17 true negative and 1 false negative. Conclusions ICRM detected SCAF in 36% of cryptogenic stroke/TIA patients within 27 months. LAVI, PAC/24h and P-duration were strong independent predictors of SCAF enabling a meaningful risk stratification that can be used for tailoring therapy in cryptogenic stroke/TIA patients. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Stiftelsen Dam
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