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Dissertations / Theses on the topic 'Stimuli-responsive release'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Cradduck, Emily. "Sonochemically-generated stimuli-responsive polymeric microspheres for controlled release." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760967.

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Ultrasonic irradiation at the interface between a protein solution and a gas or non-aqueous liquid facilitates the formation of protein-shelled microspheres by a phenomenon of simultaneous emulsification and encapsulation. Sonochemically-generated hollow proteinaceous microspheres have been widely reported in the literature, with a range of current and potential applications including ultrasound contrast agents, drug delivery vehicles and nutrient carriers in the food processing industry. This project builds upon preliminary investigations conducted in the field into the use of synthetic polym

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2

Zhou, Jun. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11001/.

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Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of IPN microgels composed of PNIPAM and PAAc have been studied. It is found that the IPN microgel dispersion can undergo a sol-gel transition at temperature above 33°C. In vivo drug release experiments suggest that the gelation procedure creates a diffusion barrier and thus leads to slow release. An e

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3

Zhou, Jun Hu Zhibing. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11001.

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4

Giri, Supratim. "Mesoporous silica nanomaterials and magnetic nanoparticles based stimuli-responsive controlled-release delivery systems." [Ames, Iowa : Iowa State University], 2008.

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5

Chikh, Alard Ibaa. "DEVELOPMENT OF NOVEL MULTI-RESPONSIVE MATERIALS CHARACTERIZED BY POTENTIAL CONTROLLED RELEASE PROPERTIES." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/279147.

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With the emergence of novel and more effective drug therapies, increased importance is being placed upon the methods by which these drugs are being delivered to the body. In conventional drug delivery systems, there is very little control over the release of drug. The effective concentration at the target site can be achieved by intermittent administration of grossly excessive doses, which, often results in constantly, unpredictable variations in plasma concentrations, with the risk of reaching levels below or above the therapeutic range leading to marked side effects. A plethora of formulatio

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6

Llopis, Lorente Antoni. "Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communication." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/117612.

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[ES] La presente tesis doctoral titulada "Nanodispositivos mesoporosos híbridos funcionalizados con enzimas para detección, liberación controlada y comunicación molecular" se centra en el diseño, preparación, caracterización y evaluación de distintos nanodispositivos híbridos orgánico-inorgánicos utilizando como soporte nanopartículas tipo Janus de oro y sílice mesoporosa, que se equipan con enzimas, especies fluorescentes y puertas moleculares. Como conclusión general, los estudios realizados muestran que la incorporación de enzimas sobre nanopartículas permite introducir funciones de recono

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7

Sanson, Charles. "Vésicules polymères biorésorbables et stimulables pour des applications en vectorisation." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR13985/document.

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L’auto-assemblage de copolymères à blocs amphiphiles est un outil puissant de la chimie supramoléculaire pour la conception de nano-objets complexes et fonctionnels. Dans ces travaux de thèse, l’étude approfondie d’un copolymère à blocs « hybride » synthétique-b-peptidique poly(triméthylène carbonate)-b-poly(acide glutamique) pour des applications de vectorisation a été menée. Des morphologies vésiculaires, obtenues par auto-assemblage en voie « co-solvant » et présentant une grande stabilité ainsi qu’un caractère stimulable ont été mises en évidence. Une transition inédite en température, par

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8

de, Luis Fernández Beatriz. "Development of enzyme-functionalized hybrid mesoporous nanodevices for advanced chemical communication." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/171506.

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Tesis por compendio<br>[ES] La presente tesis doctoral se centra en el diseño, síntesis y caracterización de varios nanodispositivos híbridos orgánico-inorgánicos, utilizando como soporte nanopartículas de sílice mesoporosa equipadas con enzimas y puertas moleculares, los cuales muestran capacidades comunicativas además de la evaluación de diferentes estrategias de comunicación. El primer capítulo incluye un resumen de diferentes conceptos sobre los que se fundamentan los estudios realizados tales como nanotecnología, materiales de sílice mesoporosa, materiales con puertas moleculares que

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9

Li, Song. "Stimuli-Responsive Materials for Controlled Release Applications." Diss., 2015. http://hdl.handle.net/10754/552156.

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The controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. To address this outstanding problem, the design and fabrication of stimuli-responsive materials are pursued to guarantee the controlled release of cargo at a specific time and with an accurate amount. Upon applying different stimuli such as light, magnetic field, heat, pH change, enzymes or redox, functional materials change their physicochemical properties through physical transformation or chemical reactions, allowing the release of payload agents on demand.

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10

Chia-WeiWang and 王嘉瑋. "Polymeric Micelles with Triple Stimuli-Responsive characteristics for Controlled Drug Release." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3h6e84.

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11

Kuthati, Yaswanth, and Yaswanth Kuthati. "FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLES FOR STIMULI RESPONSIVE DRUG RELEASE & ANTIMICROBIAL PHOTODYNAMIC THERAPY." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/88130162472406996083.

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博士<br>國立東華大學<br>生命科學系<br>104<br>Functional silica-based nanomaterials have recently received much attention due to their unique physiochemical properties. Studies on functionalized mesoporous silica nanoparticle (MSN) for various applications in the field of biomedicine have seen a significant increase, with an ultimate goal to extend these functionalized nanomaterials for therapeutic and diagnostic applications. Herein, the synthesis and characterization of MSN-based nanomaterials for stimuli responsive drug delivery and phototherapeutic applications are described. First the study was focused

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12

Wang, Cheng-Fan, and 王晨帆. "Studies on Drug Release of Nanoparticles Synthesized with Stimuli-Responsive Polymers: Chitosan and PNIPAAm." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/73985886575970611386.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>99<br>In this research, the stimuli-responsive polymers: chitosan(CS) and poly(N-isopropylacrylamide)(PNIPAAm) were used to synthesize the nanoparticles as a drug carrier. The amount of pH-sensitive polymer, chitosan, was adjusted to a proper molar ratio with acetic acid(HAc) to form CS/HAc micelles by self-assembly. Next, NIPAAm was introduced into the system and initialized by potassium persulfate(KPS) at high temperature which was higher than Lower Critical Concentration Temperature(LCST) of PNIPAAm; therefore, PNIPAAm polymer chain would become hydrophobic

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13

Chi-MingHuang and 黃祈銘. "Stimuli-responsive and Targeting Polymeric Micelles for the Applications of Controlled Drug Release and Target Delivery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/40019228348250310986.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>101<br>In this work, a new series of mixed polymeric micelles with multi-functionalities was investigated and their application as the carrier of anti-cancer drugs was explored. These micelles were self-assembled from two amphiphilic diblock copolymers, poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- 6-(methacrylamido)hexanoic acid] [PCL-b-P(TEGMA-co-AHA)] and poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- N-(2-(methacrylamido)ethyl) folatic amide] [PCL-b-P(TEGMA-co-FA)]. The hydrophobic core of micelles composed of the PCL block c

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14

Lai, Cheng-Yu. "Multifunctional mesoporous silica nanospheres for biosensor, stimuli-responsive controlled-release drug delivery carriers and gene transfection vectors /." 2004.

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15

Caldas, Mariana Elisabete Rodrigues de. "Electro-responsive controlled drug delivery from melanin nanoparticles." Master's thesis, 2018. http://hdl.handle.net/10316/84399.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Electro-responsive controlled drug delivery has been attracting an increasing interest as one of the on-demand drug delivery systems, which aims to improve the efficacy of therapeutics by controlling the amount of drug release at a specific time and target site. “Smart-materials" have been exploited for this matter, as they can modulate their inherent physical properties by means of external stimuli, triggering the release of an active agent. Herein, we report a simple method to develop

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16

Ταπεινός, Χρήστος. "Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών". Thesis, 2013. http://hdl.handle.net/10889/7889.

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Σκοπός της παρούσας διδακτορικής διατριβής είναι η σύνθεση, ο χαρακτηρισμός και η βιολογική αξιολόγηση τροποποιημένων πολυλειτουργικών νανοπεριεκτών (ΠΝΠ) ως συστημάτων μεταφοράς φαρμάκων (ΣΜΦ), με άμεση εφαρμογή στη θεραπεία του καρκίνου του μαστού και του προστάτη. Με τον όρο νανοπεριέκτες (ΝΠ) εννοούμε τα σωματίδια τα οποία βρίσκονται στην κλίμακα του νανομέτρου και κυμαίνονται σε διαστάσεις από περίπου 1nm έως και 100 nm. Ο όρος πολυλειτουργικά αναφέρεται στις ιδιότητες αυτών των νανοδομών και πιο συγκεκριμένα στο πως μεταβάλλονται οι ιδιότητες αυτών όταν υπάρχει επίδραση εξωτερικών παραγό

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17

Kanaan, Akel Ferreira. "Ionic liquid based functionalized materials for the development of multi-responsive electroactive hydrogels." Doctoral thesis, 2021. http://hdl.handle.net/10316/95400.

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Tese no âmbito do doutoramento em Engenharia Química, apresentada ao Departamento de Engenharia Química da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>The main objective of the present thesis was the development and characterization of novel electroactive ionic liquid-based polycationic hydrogels. These materials were obtained by the functionalization of natural-origin and/or synthetic polymers with an ionic liquid-based vinyl monomer (functionalized at the cation) by two different approaches, namely by the formation of semi-interpenetrating polymer networks (s-IPNs) and

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