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Journal articles on the topic 'Stimuli-responsive release'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Okano, Teruo, and Yasuhisa Sakurai. "Stimuli-responsive drug release system." Kobunshi 39, no. 9 (1990): 662–65. http://dx.doi.org/10.1295/kobunshi.39.662.

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2

Wells, Carlos M., Michael Harris, Landon Choi, Vishnu Priya Murali, Fernanda Delbuque Guerra, and J. Amber Jennings. "Stimuli-Responsive Drug Release from Smart Polymers." Journal of Functional Biomaterials 10, no. 3 (2019): 34. http://dx.doi.org/10.3390/jfb10030034.

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Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release in response to either chemical, physical, or biological triggers. The stimuli-responsiveness of smart biomaterials may improve spatiotemporal specificity of release. The material design may be used to tailor smart polymers to release a drug when particular stimuli are present. Smart biomaterials may use internal or external stimuli as triggering m

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3

An, Xueqin. "Stimuli-responsive liposome and drug release." SCIENTIA SINICA Chimica 45, no. 4 (2015): 340–49. http://dx.doi.org/10.1360/n032014-00252.

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4

Peng, Xingxing, Yanfei Liu, Feicheng Peng, et al. "Aptamer-controlled stimuli-responsive drug release." International Journal of Biological Macromolecules 279 (November 2024): 135353. http://dx.doi.org/10.1016/j.ijbiomac.2024.135353.

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5

Liu, Zhuang, Xiao-Jie Ju, Wei Wang, et al. "Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications." Current Pharmaceutical Design 23, no. 2 (2017): 295–301. http://dx.doi.org/10.2174/1381612822666161021141429.

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Background: In conventional drug delivery, the drug concentration in the blood raises once the drug taken, and then peaks and declines. Since each drug has a level above which it is toxic and another level below which it is ineffective, the drug concentration in a patient at a particular time depends on compliance with the prescribed routine. Methods: To achieve more effective efficacy and fewer side effects of drugs, the drug carriers with desirable dosing and controllable release property of drugs are highly desired. Stimuli-responsive capsules with smart gating membranes or hydrogel-based m

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6

Sheng, Yan, Jiaming Hu, Junfeng Shi, and Ly James Lee. "Stimuli-responsive Carriers for Controlled Intracellular Drug Release." Current Medicinal Chemistry 26, no. 13 (2019): 2377–88. http://dx.doi.org/10.2174/0929867324666170830102409.

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Background: Stimuli-responsive carriers are a class of drug delivery systems which can change their physicochemical properties and/or structural conformations in response to specific stimuli. Although passive and active drug targeting has proved to reduce the side effects to normal cells, controlled intracellular drug release should be included in drug carriers to enhance the bioavailability of drugs at the disease site. Methods: This review focuses on several recent advances in the development of stimuli-responsive carriers for spatially and temporally controlled release of therapeutic agents

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Li, Song, Wengang Li, and Niveen M. Khashab. "Stimuli responsive nanomaterials for controlled release applications." Nanotechnology Reviews 1, no. 6 (2012): 493–513. http://dx.doi.org/10.1515/ntrev-2012-0033.

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AbstractThe controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. Coupled with excellent biocompatibility profiles, various nanomaterials have showed great promise for biomedical applications. Stimuli-responsive nanomaterials guarantee the controlled release of cargo to a given location, at a specific time, and with an accurate amount. In this review, we have combined the major stimuli that are currently used to achieve the ultimate goal of controlled and targeted release by “smart” nanomaterials. The most heavily ex

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Štular, Danaja, Matic Šobak, Mohor Mihelčič, et al. "Proactive Release of Antimicrobial Essential Oil from a “Smart” Cotton Fabric." Coatings 9, no. 4 (2019): 242. http://dx.doi.org/10.3390/coatings9040242.

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Two temperature and pH responsive submicron hydrogels based on poly(N- methylenebisacrylamide), chitosan and β-cyclodextrines (PNCS/CD hydrogel) with varying poly(N-isopropylacrylamide) to chitosan ratios were synthesized according to a simplified procedure, reflecting improved stimuli responsive properties and excellent bio-barrier properties, granted by incorporated chitosan. Hydrogels were applied to cotton-cellulose fabric as active coatings. Subsequently, antimicrobially active savory essential oil (EO) was embedded into the hydrogels in order to develop temperature- and pH-responsive cot

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9

Malachowski, Kate, Joyce Breger, Hye Rin Kwag, et al. "Stimuli-Responsive Theragrippers for Chemomechanical Controlled Release." Angewandte Chemie 126, no. 31 (2014): 8183–87. http://dx.doi.org/10.1002/ange.201311047.

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10

Malachowski, Kate, Joyce Breger, Hye Rin Kwag, et al. "Stimuli-Responsive Theragrippers for Chemomechanical Controlled Release." Angewandte Chemie International Edition 53, no. 31 (2014): 8045–49. http://dx.doi.org/10.1002/anie.201311047.

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11

Zhan, Kaibei. "Application of Different Stimuli-Responsive Polymeric Micelles for Drug Release." Highlights in Science, Engineering and Technology 26 (December 30, 2022): 320–27. http://dx.doi.org/10.54097/hset.v26i.3992.

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Achieving controlled release of drugs in disease treatment can greatly improve the utilization rate and therapeutic effect of drugs. Therefore, the development of functional materials with controllable drug release has received more and more attention, such as stimuli-responsive polymeric micelles. The so-called stimuli-responsive polymeric micelles are a new type of polymer micelles that can be used to give responses to different stimulus conditions, such as endogenous stimuli (e.g. light, temperature, ultrasound intensity, magnetic field or electric field) and exogenous stimuli (e.g. redox p

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12

Das, Bhaskar C., Parthiban Chokkalingam, Pavithra Masilamani, Srushti Shukla, and Sasmita Das. "Stimuli-Responsive Boron-Based Materials in Drug Delivery." International Journal of Molecular Sciences 24, no. 3 (2023): 2757. http://dx.doi.org/10.3390/ijms24032757.

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Drug delivery systems, which use components at the nanoscale level as diagnostic tools or to release therapeutic drugs to particular target areas in a regulated manner, are a fast-evolving field of science. The active pharmaceutical substance can be released via the drug delivery system to produce the desired therapeutic effect. The poor bioavailability and irregular plasma drug levels of conventional drug delivery systems (tablets, capsules, syrups, etc.) prevent them from achieving sustained delivery. The entire therapy process may be ineffective without a reliable delivery system. To achiev

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13

Suzuki, Kazuya, Takeshi Yumura, Yuko Tanaka, and Mitsuru Akashi. "pH-Responsive Model Drug Release from Silica-Poly(methacrylic acid) Interpenetrating Gel Hybrids." Journal of Bioactive and Compatible Polymers 16, no. 5 (2001): 409–18. http://dx.doi.org/10.1106/1h3c-hn3r-ykua-2b29.

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Stimuli-responsive gel was hybridized with porous silica particles, by radical polymerization of methacrylic acid (MA) in the presence of a crosslinker. Brilliant Blue FCF (BBFCF) was encapsulated in the core of the particle and its release behavior from the particle under specific stimuli was studied. PMA gel hybridized silica particles showed specific release behavior at different pH values while normal silica particles released BBFCF at the same rate at all pHs.

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14

Oshiro-Júnior, João A., Camila Rodero, Gilmar Hanck-Silva, et al. "Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer." Current Medicinal Chemistry 27, no. 15 (2020): 2494–513. http://dx.doi.org/10.2174/0929867325666181009120610.

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Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). In addition, they can be developed using different strategies, such as functionalization with signaling molecules, leading to several advantages, such as (a) improved pharmaceutical properties of

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15

Saravanakumar, Kandasamy, Xiaowen Hu, Davoodbasha M. Ali, and Myeong-Hyeon Wang. "Emerging Strategies in Stimuli-Responsive Nanocarriers as the Drug Delivery System for Enhanced Cancer Therapy." Current Pharmaceutical Design 25, no. 24 (2019): 2609–25. http://dx.doi.org/10.2174/1381612825666190709221141.

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The conventional Drug Delivery System (DDS) has limitations such as leakage of the drug, toxicity to normal cells and loss of drug efficiency, while the stimuli-responsive DDS is non-toxic to cells, avoiding the leakage and degradation of the drug because of its targeted drug delivery to the pathological site. Thus nanomaterial chemistry enables - the development of smart stimuli-responsive DDS over the conventional DDS. Stimuliresponsive DDS ensures spatial or temporal, on-demand drug delivery to the targeted cancer cells. The DDS is engineered by using the organic (synthetic polymers, liposo

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16

Yeingst, Tyus J., Julien H. Arrizabalaga, and Daniel J. Hayes. "Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels." Gels 8, no. 9 (2022): 554. http://dx.doi.org/10.3390/gels8090554.

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Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external triggers that have been used, ultrasound possesses several advantages: it is non-invasive, has deep tissue penetration, and can safely transmit acoustic energy to a localized area. This review summarizes the current state of understanding about ultrasound-responsive hydrogels used for drug delivery.

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17

Ozaydin-Ince, Gozde, Karen K. Gleason, and Melik C. Demirel. "A stimuli-responsive coaxial nanofilm for burst release." Soft Matter 7, no. 2 (2011): 638–43. http://dx.doi.org/10.1039/c0sm00922a.

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18

Ganivada, Mutyala Naidu, Vijayakameswara Rao N, Himadri Dinda, Pawan Kumar, Jayasri Das Sarma, and Raja Shunmugam. "Biodegradable Magnetic Nanocarrier for Stimuli Responsive Drug Release." Macromolecules 47, no. 8 (2014): 2703–11. http://dx.doi.org/10.1021/ma500384m.

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19

Dong, Jie, Yani Wang, Jian Zhang, et al. "Multiple stimuli-responsive polymeric micelles for controlled release." Soft Matter 9, no. 2 (2013): 370–73. http://dx.doi.org/10.1039/c2sm27116h.

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20

Pareek, Aditya, Shantanu Maheshwari, Sivakumar Cherlo, Rama Subba Reddy Thavva, and Venkataramana Runkana. "Modeling drug release through stimuli responsive polymer hydrogels." International Journal of Pharmaceutics 532, no. 1 (2017): 502–10. http://dx.doi.org/10.1016/j.ijpharm.2017.09.001.

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21

Chen, Xuecheng, Hongmin Chen, Carla Tripisciano, et al. "Carbon‐Nanotube‐Based Stimuli‐Responsive Controlled‐Release System." Chemistry – A European Journal 17, no. 16 (2011): 4454–59. http://dx.doi.org/10.1002/chem.201003355.

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22

Wei, Jie, Xiao-Jie Ju, Xiao-Yi Zou, et al. "Multi-Stimuli-Responsive Microcapsules for Adjustable Controlled-Release." Advanced Functional Materials 24, no. 22 (2014): 3312–23. http://dx.doi.org/10.1002/adfm.201303844.

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23

Sunayana, Sunayana Rahul Vikhe, Parmeshwar Pathade, and Bhavana R. Tambe. "Stimuli-Responsive Nanocarriers: Revolutionizing Site-Specific Drug Release." Medical and Pharmaceutical Journal 4, no. 2 (2025): 79–99. https://doi.org/10.55940/medphar2025118.

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Smart nano-carriers for drug delivery are opening new frontiers as they respond to stimuli inside the human body and/or from outside as well, with the scope to release the drug at the desired time and place with responsive to stimuli like pH, temperature, enzymes, redox potential, light, ultrasound, and/or magnetic fields. Pathological microenvironments such as, acidic pH in tumor tissues or high glutathione in cancer cells are used by these smart systems to release the drug at a targeted site thus reducing general side effects and improving the therapeutic index. Effective scenarios encompass

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24

Yang, Qinglin, Weiwei Xu, Ming Cheng, et al. "Controlled release of drug molecules by pillararene-modified nanosystems." Chemical Communications 58, no. 20 (2022): 3255–69. http://dx.doi.org/10.1039/d1cc05584d.

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In this review, we summarize the advance of stimuli-responsive pillararene modified nanosystems for controlled release of drugs from the perspectives of decomposition release and gated release, and describe in detail the controlled release of recently developed photo-, pH-, thermal-, chemical- and multi-responsive nanosystems.

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25

Haleem, Kainat, and Muhammad Arslan Khan. "A review on smart bioresponsive drug delivery systems." Journal of Contemporary Pharmacy 3, no. 1 (2019): 26–34. http://dx.doi.org/10.56770/jcp2019315.

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During the past several decades, many sensing mechanisms have emerged, which provide new control strategies for designing closed-loop drug delivery systems. For such systems, numerous bioresponsive materials are utilized to construct functional modules for the desired devices. The typical closed-loop drug delivery systems recently reported in this review. The stimuli-responsive polymers serve to provide a snapshot of the utility and complexity of polymers that can sense, process, and respond to stimuli in modulating the release of a drug. Stimuli-responsive drug delivery vehicles come in the f

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26

Agiba, Ahmed M., José Luis Arreola-Ramírez, Verónica Carbajal, and Patricia Segura-Medina. "Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies." Molecules 29, no. 3 (2024): 636. http://dx.doi.org/10.3390/molecules29030636.

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In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are capable of releasing their cargos in response to specific stimuli. These intelligent-responsive nanocarriers can be further surface-functionalized so as to achieve active tumor targeting in a sequential manner, which can be simply modulated by the stimuli. By applying this methodological approach, thes

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27

Supraba, Widayanti, Patihul Husni, Aghnia Hazrina, Mayang Kusuma Dewi, and Anis Yohana Chaerunisaa. "Challenges and Strategies in Nanoparticle-Mediated Drug Release: Mechanisms and Future Directions." Trends in Sciences 22, no. 10 (2025): 10344. https://doi.org/10.48048/tis.2025.10344.

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Nanoparticle drug delivery systems (NPDDS) promise to increase the efficacy and safety of therapeutic agents, yet achieving controlled and sustained release of active ingredients from these nanoparticles remains a significant challenge hindering the full realization of this technology’s benefits. This paper aims to uncover the key problems associated with nanoparticle drug release by delving into the fundamental concepts and mechanisms underlying this intricate process. Drug release mechanisms like diffusion, erosion, and stimuli-responsive release are intricately examined, while critically ev

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Liu, Gengqi, Jonathan F. Lovell, Lei Zhang, and Yumiao Zhang. "Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment." International Journal of Molecular Sciences 21, no. 17 (2020): 6380. http://dx.doi.org/10.3390/ijms21176380.

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Stimulus-responsive drug delivery systems generally aim to release the active pharmaceutical ingredient (API) in response to specific conditions and have recently been explored for disease treatments. These approaches can also be extended to molecular imaging to report on disease diagnosis and management. The stimuli used for activation are based on differences between the environment of the diseased or targeted sites, and normal tissues. Endogenous stimuli include pH, redox reactions, enzymatic activity, temperature and others. Exogenous site-specific stimuli include the use of magnetic field

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29

Xiang, Zhichu, Mouquan Liu, and Jun Song. "Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery." Applied Sciences 11, no. 20 (2021): 9541. http://dx.doi.org/10.3390/app11209541.

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Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delin

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30

Jiang, Shuai, Katharina Landfester, and Daniel Crespy. "Control of the release of functional payloads from redox-responsive nanocapsules." RSC Advances 6, no. 106 (2016): 104330–37. http://dx.doi.org/10.1039/c6ra22733c.

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31

Zhang, Xin, Han Zhang, Xiaonan Liu, Jiao Wang, Shifeng Li, and Peng Gao. "Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications." Polymers 16, no. 22 (2024): 3163. http://dx.doi.org/10.3390/polym16223163.

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Bridged polysilsesquioxanes (BPSs) are emerging biomaterials composed of synergistic inorganic and organic components. These materials have been investigated as ideal carriers for therapeutic and diagnostic systems for their favorable properties, including excellent biocompatibility, physiological inertia, tunable size and morphology, and their extensive design flexibility of functional organic groups to satisfy diverse application requirements. Stimuli-responsive BPSs can be activated by both endogenous and exogenous stimuli, offering a precise, safe, and effective platform for the controlled

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32

Dumitriu, Raluca Petronela, Ana Maria Oprea, and Cornelia Vasile. "Kinetics of Swelling and Drug Release from PNIPAAm/Alginate Stimuli Responsive Hydrogels." Solid State Phenomena 154 (April 2009): 17–22. http://dx.doi.org/10.4028/www.scientific.net/ssp.154.17.

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Stimuli responsive hydrogels are very attractive for applications in sustained and/or targeted drug delivery systems. As the release of drugs is related to the swelling behavior of hydrogels, the swelling kinetic studies become of great importance to appreciate the release kinetics from hydrogel matrices. Hydrogels with high performance properties have been prepared from N-isopropylacryl amide (NIPAAm) and sodium alginate, crosslinked with N,N`-methylene-bis-(acrylamide) (MBAAm). This study is focused on the investigation of swelling and drug release kinetics, coupled by morphological studies.

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Jia, Xintao, Zixuan Dou, Ying Zhang, et al. "Smart Responsive and Controlled-Release Hydrogels for Chronic Wound Treatment." Pharmaceutics 15, no. 12 (2023): 2735. http://dx.doi.org/10.3390/pharmaceutics15122735.

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Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves low pH, high levels of reactive oxygen species, and specific enzyme expression. Therefore, smart responsive hydrogels that can sense and respond to these stimuli are needed. Crucially, smart responsive hydrogels can modulate drug release and eliminate pathological factors by

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34

Bazmi zeynabad, Fatemeh, Roya Salehi, Effat Alizadeh, Hossein Samadi Kafil, Azad Mohammad Hassanzadeh, and Mehrdad Mahkam. "pH-Controlled multiple-drug delivery by a novel antibacterial nanocomposite for combination therapy." RSC Advances 5, no. 128 (2015): 105678–91. http://dx.doi.org/10.1039/c5ra22784d.

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35

Šálek, Petr, Jana Dvořáková, Sviatoslav Hladysh, et al. "Stimuli-responsive polypeptide nanogels for trypsin inhibition." Beilstein Journal of Nanotechnology 13 (June 22, 2022): 538–48. http://dx.doi.org/10.3762/bjnano.13.45.

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A new type of hydrophilic, biocompatible, and biodegradable polypeptide nanogel depots loaded with the natural serine protease inhibitor α1-antitrypsin (AAT) was applied for the inhibition of the inflammatory mediator trypsin. Two types of nanogels were prepared from linear synthetic polypeptides based on biocompatible and biodegradable poly[N5-(2-hydroxyethyl)-ʟ-glutamine-ran-N5-propargyl-ʟ-glutamine-ran-N5-(6-aminohexyl)-ʟ-glutamine]-ran-N5-[2-(4-hydroxyphenyl)ethyl)-ʟ-glutamine] (PHEG-Tyr) or biocompatible Nα-ʟ-lysine-grafted α,β-poly[(2-propyne)-ᴅ,ʟ-aspartamide-ran-(2-hydroxyethyl)-ᴅʟ-aspa

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36

Choi, Moonhyun, Arman Moini Jazani, Jung Kwon Oh, and Seung Man Noh. "Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide." Polymers 14, no. 11 (2022): 2240. http://dx.doi.org/10.3390/polym14112240.

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Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few seconds in a stable state, the design and development of effective exogenous NO supply nanocarriers are essential. Additionally, the delivery of desired drugs with NO can produce synergistic effects. Herein, we report a new approach that allows for the fabrication of dual ultrasound (US)/glutathione (GSH)-responsive perfluorocarbon (PFC) nan

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Dahan, Wasmia Mohammed, Faruq Mohammad, AbdelRahman O. Ezzat, Ayman M. Atta, Hissah Hamad Al-Tilasi, and Hamad A. Al-Lohedan. "Enhanced Delivery of Insulin through Acrylamide-Modified Chitosan Containing Smart Carrier System." Gels 8, no. 11 (2022): 701. http://dx.doi.org/10.3390/gels8110701.

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The present study develops on insulin-release studies from the chitosan-amide-modified stimuli-responsive polymers formed from various fatty acids including stearic acid, oleic acid, linoleic acid, and linolenic acid. This is the continuation of an earlier reported study that investigates the insulin-release profiles of chitosan-modified fatty acid amides (without stimuli responsive polymers). Following the synthesis and characterization of many different fatty acid amides with a varying amount of unsaturation, the insulin drug loading and release effects were compared among N-isopropylacrylam

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Zaborniak, Izabela, Angelika Macior, and Paweł Chmielarz. "Stimuli-Responsive Rifampicin-Based Macromolecules." Materials 13, no. 17 (2020): 3843. http://dx.doi.org/10.3390/ma13173843.

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This paper presents the modification of the antibiotic rifampicin by an anionic polyelectrolyte using a simplified electrochemically mediated atom transfer radical polymerization (seATRP) technique to receive stimuli-responsive polymer materials. Initially, a supramolecular ATRP initiator was prepared by an esterification reaction of rifampicin hydroxyl groups with α-bromoisobutyryl bromide (BriBBr). The structure of the initiator was successfully proved by nuclear magnetic resonance (1H and 13C NMR), Fourier-transform infrared (FT-IR) and ultraviolet–visible (UV-vis) spectroscopy. The prepare

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Malta, Rafaela, Ana Camila Marques, Paulo Cardoso da Costa, and Maria Helena Amaral. "Stimuli-Responsive Hydrogels for Protein Delivery." Gels 9, no. 10 (2023): 802. http://dx.doi.org/10.3390/gels9100802.

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Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transit

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40

Chang, Ray, and Wei-Bor Tsai. "Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy." Polymers 10, no. 10 (2018): 1098. http://dx.doi.org/10.3390/polym10101098.

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Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, releas

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41

Kasiński, Adam, Monika Zielińska-Pisklak, Ewa Oledzka, and Marcin Sobczak. "Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems." International Journal of Nanomedicine Volume 15 (June 2020): 4541–72. http://dx.doi.org/10.2147/ijn.s248987.

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42

Tang, Qi, Bing Yu, Lilong Gao, Hailin Cong, Na Song, and Chenghao Lu. "Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release." Current Medicinal Chemistry 25, no. 16 (2018): 1837–66. http://dx.doi.org/10.2174/0929867325666180111095913.

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Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced. Taking this into account, stimuli responsive nanoparticles p

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Ji, Xingyue, and Zhiyuan Zhong. "External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release." Journal of Controlled Release 351 (November 2022): 81–101. http://dx.doi.org/10.1016/j.jconrel.2022.09.026.

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44

Qing, Guangyan, Minmin Li, Lijing Deng, Ziyu Lv, Peng Ding, and Taolei Sun. "Smart Drug Release Systems Based on Stimuli-Responsive Polymers." Mini-Reviews in Medicinal Chemistry 13, no. 9 (2013): 1369–80. http://dx.doi.org/10.2174/13895575113139990062.

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45

Santiago-Cordoba, Miguel, Özge Topal, David L. Allara, A. Kaan Kalkan, and Melik C. Demirel. "Stimuli Responsive Release of Metalic Nanoparticles on Semiconductor Substrates." Langmuir 28, no. 14 (2012): 5975–80. http://dx.doi.org/10.1021/la3002256.

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Chang, Ming-Wei, Mohan Edirisinghe, and Eleanor Stride. "Ultrasound mediated release from stimuli-responsive core–shell capsules." Journal of Materials Chemistry B 1, no. 32 (2013): 3962. http://dx.doi.org/10.1039/c3tb20465k.

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Bhattacharya, Sayantani, Mutyala Naidu Ganivada, Himadri Dinda, Jayasri Das Sarma, and Raja Shunmugam. "Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin." ACS Omega 1, no. 1 (2016): 108–17. http://dx.doi.org/10.1021/acsomega.6b00018.

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Wu, Hao, Jie Dong, Xiaowei Zhan, et al. "Triple stimuli-responsive crosslinked polymeric nanoparticles for controlled release." RSC Advances 4, no. 67 (2014): 35757. http://dx.doi.org/10.1039/c4ra05661b.

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Wang, Yucai, Min Suk Shim, Nathanael S. Levinson, Hsing-Wen Sung, and Younan Xia. "Stimuli-Responsive Materials for Controlled Release of Theranostic Agents." Advanced Functional Materials 24, no. 27 (2014): 4206–20. http://dx.doi.org/10.1002/adfm.201400279.

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Raza, Ali, Tahir Rasheed, Faran Nabeel, Uzma Hayat, Muhammad Bilal, and Hafiz Iqbal. "Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release." Molecules 24, no. 6 (2019): 1117. http://dx.doi.org/10.3390/molecules24061117.

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Abstract:

In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (e

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