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Che Lah, Nur Azida, and Muhamad Hellmy Hussin. "Kesan Logam Pengisi Terhadap Struktur Terkimpal Al 6061 Yang Teroksida Pada 600°C." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 78, no. 1 (2020): 48–59. http://dx.doi.org/10.37934/arfmts.78.1.4859.
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Samples of STK 6061 ER 4043 and STK 6061 ER 5356 were welded respectively using ER 4043 (Al-5%Si) and ER 5356 (Al-5%Mg) filler metal and were oxidized in air environment at 600oC for 40 hours. The focus of the analysis is on the welded metal where the base metal and the filler metal melt together to produce different chemical compositions. The analysis includes kinetic oxidation, material defect testing, surface morphology characterization using SEM-EDX, cross sectioning, elemental mapping and the oxide phases formed on the alloy surface. The results show that welded metal containing Mg tends to accelerate and accelerate the oxidation process, whereas welded metal containing Si may increase the resistance to oxidation.
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Eliasson, Pär. "600 Years of Travelling Students." Science & Technology Studies 5, no. 2 (1992): 29–42. http://dx.doi.org/10.23987/sts.55041.
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Komai, Seitaro, Norihiko Yokoi, Hiroaki Kato, et al. "Clinical Implication of Patchy Pattern Corneal Staining in Dry Eye Disease." Diagnostics 11, no. 2 (2021): 232. http://dx.doi.org/10.3390/diagnostics11020232.
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Corneal fluorescein staining in a form that is commonly called a “patchy pattern (PP)” is sometimes seen with or without superficial punctate keratopathy (SPK) in dry-eye diseases (DEDs). Here, we investigated the differences in the clinical features of DED patients with and without PP corneal staining (PPCS). This study involved 35 DEDs with PPCS (PPCS group) and 30 DEDs with SPK and without PPCS (non-PPCS group). The tear meniscus radius (TMR, mm), spread grade (SG) of the tear-film lipid layer (i.e., SG 1–5, 1 being best), noninvasive breakup time (NIBUT, seconds), fluorescein breakup time (FBUT, seconds), corneal epithelial damage (CED, 15 points maximum), conjunctival epithelial damage (CjED, six points maximum), the Schirmer’s 1 test (ST1, mm), and the prevalence of Sjögren’s syndrome (SS) were examined, and then compared between the two groups. Our findings revealed that between the groups (PPCS vs. non-PPCS), there was a statistically significant difference (p < 0.05) in CjED (3.1 ± 1.9 vs. 1.3 ± 1.6), ST1 (5.6 ± 7.4 vs. 14.8 ± 11.4), and the prevalence of SS (60.0% vs. 16.7%). Our findings suggest that DEDs and dry-eye patients with PPCS may indicate not only SS itself, but also the ophthalmological characteristics compatible with SS.
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Mustakim, Alik, Yusep Muslih Purwana, Ary Setyawan, and Mamok Suprapto. "Technical Review of Slope Failure (Case Study of Tawangmangu-Cemorosewu Sta. 4+600 Section)." Applied Mechanics and Materials 845 (July 2016): 76–82. http://dx.doi.org/10.4028/www.scientific.net/amm.845.76.
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Tawangmangu-Sarangan highway is a national strategic road connecting two districts in two provinces; Karanganyar in Central Java and Magetan in East Java. The topography of the area is relatively high due to stiff hill and valley with the problematic geologic condition of weathered rock and silt sand. During rainy season, slope failures at some sections of this road were very often. The study to understand the cause of the failures is very important. Deep boring may have the best result to obtain soil parameter and stratigraphy of soil layer. However, this method was impossible due to the safety reason. The use of geophysic instrument such as geoelectric for the investigation combined with hand boring for soil sampling was a reasonable choice. Geoelecetric was utilized to predict soil layers properties and potential failure surface of the slope. This study was focused on the investigation on a slope failure location of Tawangmangu-Cemorosewu at Sta 4+600. Finite element software was utilized to understand the cause of previous failure and to model the most critical failure surface that may occurre in the future. Based on the modeling, the safety factor of the slope was 1.18 and 0.930 before and during construction. The condition of the slope after failure is still very critical due to the very low safety factor of 1.03 causing the potential of failure. It also recommended that geometrical method such as terrasering might be one of the solutions producing the safety fractor of 1.5.
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Wardhana, Raden Aditya nandi. "PENGARUH KEPEMIMPINAN KEPALA SEKOLAH, PROFESIONALISME DAN PELATIHAN GURU TERHADAP IMPLEMENTASI KURIKULUM 2013 SMKN YOGYAKARTA." Jurnal Akuntabilitas Manajemen Pendidikan 4, no. 2 (2016): 257. http://dx.doi.org/10.21831/amp.v4i2.10812.
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Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan kepala sekolah, profesionalisme guru, dan pelatihan guru secara bersama-sama terhadap implementasi Kurikulum 2013 di lima SMK Negeri Kota Yogyakarta. Penelitian ini menggunakan pendekatan kuantitatif dengan desain korelasional. Dari populasi sejumlah 600 guru, diambil sampel sejumlah 234 guru dengan menggunakan teknik proportional random sampling. Analisis data penelitian menunjukkan: kepemimpinan kepala sekolah berpengaruh terhadap implementasi Kurikulum 2013 di SMK Negeri Kota Yogyakarta (p < 0,05). Profesionalisme guru berpengaruh terhadap implementasi Kurikulum 2013 di SMK Negeri Kota Yogyakarta (p < 0,05). Pelatihan guru berpengaruh terhadap implementasi Kurikulum 2013 di SMK Negeri Kota Yogyakarta (p < 0,05). Kepemimpinan kepala sekolah, profesionalisme guru, dan pelatihan guru secara bersama-sama berpengaruh terhadap implementasi Kurikulum 2013 di SMK Negeri Kota Yogyakarta (p < 0,05). Kata kunci: kepemimpinan, profesionalime guru, pelatihan, kurikulum 2013 THE EFFECT PRINCIPAL’S LEADERSHIP, PROFESSIONALISM AND TEACHER TRAINING ON THE IMPLEMENTATION OF CURRICULUM 2013 IN SMKN YOGYAKARTA Abstract This study aimed to determine the effect of school leadership, teacher professionalism and teachers’ training together towards the implementation of Curriculum 2013 at five of SMK Negeri Yogyakarta. This study uses a quantitative study with a co-relational design. The research population were 600 teachers, 234 teachers were drawn as sample by using proportional random sampling technique. The data analysis showed that: school leadership affect the implementation of Curriculum 2013 in SMK Kota Yogyakarta (p<0.05).Keywords: Leadership, Professionalism teacher, Training, Curriculum 2013
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Morton, R. S. "The New Hite Report: Shere Hite. pound12.99; Pp 667. London: Hamlyn, 2000. ISBN 0-600-60116-1." Sexually Transmitted Infections 77, no. 2 (2001): 151. http://dx.doi.org/10.1136/sti.77.2.151.
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Kriswardhana, Willy, Dewi Junita Koesoemawati, and Trio Sagita Susanto. "EVALUATION OF FLEXIBLE PAVEMENT DAMAGE DEGREE WITH PAVEMENT CONDITION INDEX METHOD (CASE STUDY: ARGOPURO ROADS - BANYUWANGI STA. 0+000 TO STA. 2+600)." Jurnal Rekayasa Sipil dan Lingkungan 2, no. 01 (2018): 1. http://dx.doi.org/10.19184/jrsl.v2i01.6892.
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Argopuro Roads Banyuwangi Regency with a length of 2.6 km is a switching route for heavy vehicles and buses from the north of Banyuwangi to Jember. The increase in traffic volume from year to year as well as the construction of factories and warehouses along the roads resulted in a decrease in road capability to receive loads on it. To know the type and the extent of damage occurring on Argopuro Roads is done a research which will be able to determine the appropriate type of maintenance. The determination of road condition is done by Pavement Condition Index method (PCI). Road improvement is calculated by using the component analysis method from Department of Highways Regulation No. 378/KPTS/1987. Based on the result of research, the index value of pavement condition in survei by using PCI method is 58.07. The improvement of road is done in the segment with the failure condition to the fair with the handling of the improvement in the form of recontruction. Based on the calculation result in this research, it resulted that the pavement structure has thickness of 10 cm surface course, thickness of 25 cm base course, and thickness of 63 cm sub base course.
 Ruas Jalan Argopuro Kabupaten Banyuwangi dengan panjang ruas 2.6 km merupakan jalur pengalih untuk kendaraan berat dan bus dari arah utara kota Banyuwangi menuju Kota Jember. Adanya peningkatan volume lalu lintas dari tahun ke tahun serta pembangunan sejumlah pabrik dan gudang pada sepanjang ruas jalan tersebut mengakibatkan menurunnya kemampuan jalan untuk menerima beban di atasnya. Untuk mengetahui jenis dan tingkat kerusakan yang terjadi pada ruas Jalan Argopuro, dilakukan penelitian yang dapat menentukan jenis pemeliharaan yang sesuai. Penentuan kondisi jalan dilakukan dengan metode Pavement Condition Index (PCI). Perbaikan jalan dihitung dengan menggunakan metode analisa komponen dari peraturan Departemen Bina Marga Nomor 378/KPTS/1987. Berdasarkan hasil penelitian, nilai indeks kondisi pekerasan jalan yang disurvei dengan menggunakan metode PCI yaitu 58,07. Perbaikan jalan dilakukan pada segmen dengan kondisi gagal (fail) hingga sedang (fair) dengan penanganan perbaikan berupa rekonstruksi. Berdasarkan hasil perhitungan pada penelitian ini menghasilkan struktur perkerasan jalan dengan ketebalan tebal lapis permukaan 10 cm, tebal lapis pondasi atas sebesar 25 cm, dan tebal lapis pondasi bawah setebal 63 cm.
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Rio, Wahyu Yusuf, and Fatmawati Fatmawati. "Evaluasi Kerusakan Jalan Soekarno-Hatta STA 09+000-STA 14+000 Kota Balikpapan." Syntax Idea 3, no. 3 (2021): 680. http://dx.doi.org/10.36418/syntax-idea.v3i3.1079.
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Pada penelitian ini dilakukan survei kondisi kerusakan jalan dengan lokasi pada km 9 hingga km 14 (STA 9+00 - STA 14+00) dengan tujuan mengetahui kondisi kerusakan jalan dan penanganannya dengan menggunakan metode Bina Marga dan Pavement Condition Index. Berdasarkan hasil analisis metode Bina Marga diketahui tingkat kerusakan jalan pada STA 9+00-STA 14+00 memiliki area sebesar 941,12 m2, adapun prioritas tertinggi sebesar 5.2 pada STA 12+000-STA 13+000 dan nilai kondisi jalan adalah 6.8. Sedangkan dari analisis dengan metode PCI diperoleh hasil indeks kondisi perkerasan sangat rendah dengan nilai PCI 14 yakni pada STA 12+850 hingga STA 12+900 dengan kategori kerusakan sangat buruk. Dari hasil penilaian kerusakan jalan maka perlu dilakukan pemeliharaan rutin dan melakukan perbaikan berupa tambalan, perawatan permukaan serta penutupan retak dapat dijadikan rekomendasi perbaikan jalan. Dari hasil penilaian terhadap kondisi jalan di ruas jalan Soekarno-Hatta STA 9+000-STA 14+000 kota Balikpapan diperoleh nilai kondisi perkerasan persegmen yang mengalami kerusakan dan harus mendapatkan prioritas penangganan terlebih dahulu yaitu STA 13+300 sampai STA 13+350 diperoleh nilai PCI 14 yang berarti dalam kondisi sangat buruk (very poor), STA 12+850 sampai STA 12+900 diperoleh nilai PCI 14 yang berarti dalam kondisi sangat buruk (very poor), STA 10+250 sampai STA 10+300 diperoleh nilai PCI 42 yang berarti dalam kondisi buruk (poor), STA 10+600 sampai STA 10+650 diperoleh nilai PCI 31 yang berarti dalam kondisi buruk (poor).
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Nugraha, Fajar, and Yuniarsi Rahayu. "SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN DAERAH PRODUKTIF PENGHASIL KOPI DI KABUPATEN PATI." Jurnal SITECH : Sistem Informasi dan Teknologi 1, no. 2 (2019): 95–98. http://dx.doi.org/10.24176/sitech.v1i2.2822.
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Kabupaten pati yang terletak di lereng gunung muria merupakan salah satu daerah penghasil kopi di Jawa Tengah. Letak geografis lereng pegunungan Muria yang berada pada ketinggian 400-600 meter di atas permukaan laut sangat mendukung untuk budidaya tanaman kopi. Berdasarkan salah satu potensi kabupaten pati tersebut pada penelitian ini akan menghasilkan sebuah sistem pendukung keputusan (SPK) untuk membantu dalam menentukan daerah penghasil kopi di kabupaten Pati.Dalam menentukan daerah penghasil kopi ini akan menggunakan metode Simple Additive Weighting. Metode dalam sistem pendukung keputusan ini akan menggunakan kriteria Benefit (keuntungan) serta kriteria Cost (biaya). Implementasi metode SPK tersebut akan digunakan untuk menentukan kecataman fi kabupaten Pati yang paling produktif dalam menghasilkan kopi. Hasil dari penelitian ini merupakan SPK yang digunakan untuk membantu dinas terkait dalam menentukan daerah penghasil kopi paling produktif di kabupaten Pati.
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Rahmayanti, Previa, Putri Ayuna Saraswati, and Gartika Pandu Bhuana. "THE USE OF ICE BREAKER TO IMPROVE STUDENTS’ MOTIVATION IN LEARNING ENGLISH AT THE TENTH GRADE STUDENTS OF SMK YPKKP." PROJECT (Professional Journal of English Education) 2, no. 5 (2019): 594. http://dx.doi.org/10.22460/project.v2i5.p594-600.
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There is a belief that ice breaking can be used in the classroom as it provides several advantages for the students. One of them is that it can improve students’ learning motivation. This study aims to prove this belief. In other words, it attempts to investigate the effectiveness of ice breaking in improving students’ learning motivation. Quantitative with one group pretest and posttest was used in this study. The population was the 10th grade students at SMK YPKKP. The sample was one class of office administration major. The data was collected through motivation test adapted from (Burhan, 2017). The result showed that null hypothesis of this study was rejected. It is proved by the data from t-test that shows the sigma 2 tailed is 0.00. This value is less than 0.05. Null hypothesis, therefore, was rejected. This means that ice breaking could definitely improve the students’ motivation in learning English. The teacher therefore can implement it in the classroom. in the title.
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Suryani, Des, and Mundayani Mundayani. "SPK Penyeleksian Calon Presiden Mahasiswa Universitas Islam Riau Menggunakan Metode Fuzzy - AHP." IT JOURNAL RESEARCH AND DEVELOPMENT 1, no. 1 (2017): 16–26. http://dx.doi.org/10.25299/itjrd.2016.vol1(1).600.
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Pemilihan raya mahasiswa adalah sebuah pesta demokrasi yang diadakan di kalangan mahasiswa yang merupakan awal dari pendidikan politik sejak dini bagi mahasiswa dan menjadi tempat mengaktualisasikan diri dan potensi yang dimiliki. Salah satu bentuk pemilihan raya mahasiswa adalah pemilihan calon presiden mahasiswa. Pemilihan calon presiden mahasiswa yang berlaku di Universitas Islam Riau saat ini masih dilakukan secara manual sehingga tidak efektif dan tidak efisien. Untuk memecahkan permasalahan tersebut dibutuhkan suatu sistem pendukung keputusan yang dapat memberikan keputusan terbaik untuk penggunanya. Sistem Pendukung Keputusan (SPK) bertujuan untuk menentukan calon presiden yang terpilih dalam proses penyeleksian berdasarkan tingkat kepentingan kriteria dan data nilai seleksi dari setiap kriteria yang telah ditetapkan. Sistem pendukung keputusan menggunakan metode fuzzy dan metode analytic hierarchy process. Metode fuzzy digunakan untuk menentukan nilai keanggotaan dari tiap-tiap nilai seleksi berdasarkan kriteria, dan metode Analytic Hierarchy Process (AHP) digunakan untuk mencari urutan prioritas dari berbagai alternative dalam proses pemecahan suatu permasalahan. Hasil perhitungan sistem pendukung keputusan ini berupa perangkingan calon presiden mahasiswa yang telah terpilih dalam proses penyeleksian. Proses perangkingan dimulai dari nilai tertinggi yang dimiliki oleh calon presiden mahasiswa dan jumlah yang terpilih menjadi kandidat presiden mahasiswa berdasarkan jumlah yang diinginkan pada periode tersebut.
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Ogden, Adam, Michael Kuhn, Michael Dority, et al. "Evaluation of Pharmacokinetic/Pharmacodynamic Relationships of PD-0162819, a Biotin Carboxylase Inhibitor Representing a New Class of Antibacterial Compounds, UsingIn VitroInfection Models." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 124–29. http://dx.doi.org/10.1128/aac.00090-11.
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ABSTRACTThe present study investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationships of a prototype biotin carboxylase (BC) inhibitor, PD-0162819, againstHaemophilus influenzae3113 in static concentration time-kill (SCTK) and one-compartment chemostatin vitroinfection models.H. influenzae3113 was exposed to PD-0162819 concentrations of 0.5 to 16× the MIC (MIC = 0.125 μg/ml) and area-under-the-curve (AUC)/MIC ratios of 1 to 1,100 in SCTK and chemostat experiments, respectively. Serial samples were collected over 24 h. For efficacy driver analysis, a sigmoid maximum-effect (Emax) model was fitted to the relationship between bacterial density changes over 24 h and corresponding PK/PD indices. A semimechanistic PK/PD model describing the time course of bacterial growth and death was developed. The AUC/MIC ratio best explained efficacy (r2= 0.95) compared to the peak drug concentration (Cmax)/MIC ratio (r2= 0.76) and time above the MIC (T>MIC) (r2= 0.88). Static effects and 99.9% killing were achieved at AUC/MIC values of 500 and 600, respectively. For time course analysis, the net bacterial growth rate constant, maximum bacterial density, and maximum kill rate constant were similar in SCTK and chemostat studies, but PD-0162819 was more potent in SCTK than in the chemostat (50% effective concentration [EC50] = 0.046 versus 0.34 μg/ml). In conclusion, basic PK/PD relationships for PD-0162819 were established usingin vitrodynamic systems. Although the bacterial growth parameters and maximum drug effects were similar in SCTK and the chemostat system, PD-0162819 appeared to be more potent in SCTK, illustrating the importance of understanding the differences in preclinical models. Additional studies are needed to determine thein vivorelevance of these results.
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ROSBERG, H. E., K. S. CARLSSON, S. HÖJGÅRD, B. LINDGREN, G. LUNDBORG, and L. B. DAHLIN. "What Determines the Costs of Repair and Rehabilitation of Flexor Tendon Injuries in Zone II? A Multiple Regression Analysis of Data from Southern Sweden." Journal of Hand Surgery 28, no. 2 (2003): 106–12. http://dx.doi.org/10.1016/s0266-7681(02)00352-2.
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The epidemiology and costs of repair and rehabilitation of zone II flexor tendon injuries in 135 patients from the southern part of Sweden were analysed. The little finger was most frequently injured (43%), usually with a knife (46%), and 30% of the injuries were work related. Total median costs within the health-care sector for the injuries were SEK 48,500 (1 EURO=9.23 SEK, 4/1/2002). Costs in other sectors were SEK 93,000. Active mobilization or mobilization with rubber band traction increased costs within the health-care sector (SEK 7400 or SEK 6000, respectively) but improved range of movement (5–7%). Immobilization had a higher complication rate (rupture or need for secondary procedures), which in itself increased total costs by 57%. Nonlinear effects were found between age and costs within the health-care sector and the outcome.
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Culebras, Antonio, R. Rotta-Escalante, J. Vila, et al. "Triflusal vs. Aspirin for the Prevention of Infarction: a Randomized Stroke Study (TAPIRSS)." Stroke 32, suppl_1 (2001): 377. http://dx.doi.org/10.1161/str.32.suppl_1.377-b.
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P208 Background: TAPIRSS is a randomized, double-blind, multicenter pilot trial designed to study the efficacy of triflusal for the prevention of secondary ischemic stroke conducted in Buenos Aires, Argentina. Triflusal is an antiplatelet agent structurally related to aspirin. Methods and Results: From October 1996 to October 1999 patients were randomized to group #1 (aspirin therapy, 325 mg/daily) or group #2 (triflusal, 600 mg/daily). All patients had experienced either an ischemic stroke (80.9%) or a transient ischemic attack within 6 months prior to randomization. Patients were treated for a median of 586 days. Data for 429 patients were analyzed. Primary endpoints were: cardiovascular death 3.7%(#1)/2.3%(#2)[OR=1.6]; cerebral ischemic infarction 7.4%(#1)/8.0%(#2)[OR=0.92]; non-fatal myocardial infarction 2.3%(#1)/1.9%(#2)[OR=1.24];severe hemorrhage any kind 3.2%(#1)/0.5%(#2)[OR=7.1][p=0.068]. Secondary endpoints were: non-vascular death 2.4%(#1)/0.5%(#2)[OR=5.02]; non-severe hemorrhage 6.0%(#1)/2.3%(#2)[OR=2.66][p=0.058]; systemic thromboembolism 0.9%(#1)/1.4%(#2)[OR=0.65]. Aggregate analysis of primary endpoints showed no significant differences between aspirin and triflusal. Aggregate analysis of secondary enpoints showed a significant difference in favor of triflusal [p=0.038]. Analysis of the combination severe and non-severe hemorrhage showed a significantly reduced incidence of hemorrhagic events with triflusal [8.3%(#1)/2.8%(#2), p=0.013]. Dyspepsia and gastrointestinal discomfort were the most common adverse events in the triflusal group. Conclusions: Triflusal shows a protective effect similar to aspirin in the prevention of secondary ischemic stroke with a lesser risk of hemorrhagic complications. Also, triflusal may be safe for the primary prevention of ischemic stroke.
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Ayu, Suci Musvita, Liena Sofiana, and Febri Utami Jayanti. "The correlation of teacher’s role, peers, and mass media with the incidence of dating violence in adolescents at SMK Piri 1 Yogyakarta." International Journal Of Community Medicine And Public Health 6, no. 6 (2019): 2325. http://dx.doi.org/10.18203/2394-6040.ijcmph20192292.
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Background: Dating violence has long-lasting and also short effects that are serious and have negative impacts severity toward physical forms of violence, psychic, economic and sexual. This study aims to know the relationship between the teachers’ role, their peers and the mass media and dating violence in adolescents at SMK PIRI 1 Yogyakarta.Methods: The design of the study is analytical survey with cross-sectional design.The sample was students of class XI of SMK Piri 1 Yogyakarta with a total of 147 respondents.A questionnaire was used to determine the relationship between the role of the teacher, peers and mass media with dating violence. Univariate and bivariate analyzes were performed with chi square test.Results: There were two variables that show there was a relationship between peers (p=0.009), mass media (p=0.019) with dating violence and there was no relationship between teacher roles and dating violence (p=1.00), peer prevalence ratio values indicate (RP=0.682), mass media (RP=1,432) and the teacher's role (RP=0,977) and confidence interval 95% confidence level, that there are peers (CI=0,528-0,888), mass media (CI = 1,067-1,922) and the teacher's role (CI=0.745-1.228).Conclusions: There is a relationship between peers and mass media with dating violence, and there is no relationship between teachers’ role and dating violence in SMK 1 Piri Yogyakarta.
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Huang, Tao, Li Jun Xin, and Zhi Yong Wang. "Study on Fiber Laser Welding for DP780 High Strength Steel." Advanced Materials Research 328-330 (September 2011): 48–53. http://dx.doi.org/10.4028/www.scientific.net/amr.328-330.48.
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Welding experiments of DP780 high strength steel plate produced by Baosteel with IPG YLR-6000-ST2 fiber laser have been processed. The influence of welding parameters on welding quality has been investigated. As well as microstructure and mechanical character of welding seam have been analyzed. The results show that the joint appearance of DP780 high strength steel welded with IPG YLR-6000-ST2 fiber laser has good performance and the mechanics property is good without fit-up gap. The microstructure of weld bead is columnar crystals, mainly lath-shaped ferrite, needle-like lower bainite and a small amount of martensite. Heat-affected zone is narrow and the grain grows with little size. The measured micro-hardness values of the sample decrease smoothly from weld center to base metal and there does not have softened zone.
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Vanderschueren, S., D. Collen, and F. Van de Werf. "A Pilot Study on Bolus Administration of Recombinant Staphylokinase for Coronary Artery Thrombolysis." Thrombosis and Haemostasis 76, no. 04 (1996): 541–44. http://dx.doi.org/10.1055/s-0038-1650619.
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SummaryRecombinant staphylokinase (Sak) is a highly fibrin-specific thrombolytic agent but the optimal dose and mode of administration remain to be defined. Intravenous (i.v.) infusion over 5 min of 20 mg Sak in 12 patients with acute myocardial infarction induced complete coronary patency (TIMI perfusion grade 3) in 7 patients (58%) within 60 min. In 3 of the 5 patients with no or suboptimal flow (TIMI grade 0,1 or 2) at 60 min, an additional 10 mg i.v. bolus of Sak resulted in TIMI grade 3 flow at 90 min. No major treatment-related complication occurred. Residual fibrinogen and α2-antiplasmin levels at 90 min were 110 ± 6.0% and 98 ±4.1% (mean ± SEM) of baseline, respectively. Median antibody-related Sak-neutralizing activity was low at baseline (0.0 μg/ml) and after 1 week (0.5 μg/ml) but increased from day 10 on (to 4.0 μg/ml).Thus, bolus thrombolysis with Sak may induce efficient coronary artery recanalization while preserving circulating fibrinogen and α2-antiplasmin. Comparative trials of coronary thrombolysis with double-bolus Sak appear to be warranted.
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Pamungkas, Ridho. "Perancangan Sistem Informasi Pembayaran Administrasi SMK Negeri 1 Jiwan." INTENSIF 1, no. 2 (2017): 129. http://dx.doi.org/10.29407/intensif.v1i2.799.
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 The rapid development of technology requires schools to provide optimal service to their students, especially in SMK Negeri 1 Jiwan. Improve the quality of information systems is one way to support services to students. The administration payment information system is designed in accordance with the circumstances in the school. The data were collected using interview method and observation method. This research produce information system design using Microsoft Visual Basic 6.0 which can help SMK Negeri 1 Jiwan to give service in administration payment of student.
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Yoon, Jung-Hoon, So-Jung Kang, Yong-Taek Jung, and Tae-Kwang Oh. "Gaetbulicola byunsanensis gen. nov., sp. nov., isolated from tidal flat sediment." International Journal of Systematic and Evolutionary Microbiology 60, no. 1 (2010): 196–99. http://dx.doi.org/10.1099/ijs.0.011015-0.
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A Gram-negative, non-motile and pleomorphic bacterial strain, SMK-114T, which belongs to the class Alphaproteobacteria, was isolated from a tidal flat sample collected in Byunsan, Korea. Strain SMK-114T grew optimally at pH 7.0–8.0 and 25–30 °C and in the presence of 2 % (w/v) NaCl. A neighbour-joining phylogenetic tree based on 16S rRNA gene sequences showed that strain SMK-114T formed a cluster with Octadecabacter species, with which it exhibited 16S rRNA gene sequence similarity values of 95.2–95.4 %. This cluster was part of the clade comprising Thalassobius species with a bootstrap resampling value of 76.3 %. Strain SMK-114T exhibited 16S rRNA gene sequence similarity values of 95.1–96.3 % to members of the genus Thalassobius. It contained Q-10 as the predominant ubiquinone and C18 : 1 ω7c as the major fatty acid. The DNA G+C content was 60.0 mol%. On the basis of phenotypic, chemotaxonomic and phylogenetic data, strain SMK-114T is considered to represent a novel species in a new genus for which the name Gaetbulicola byunsanensis gen. nov., sp. nov. is proposed. The type strain of Gaetbulicola byunsanensis is SMK-114T (=KCTC 22632T =CCUG 57612T).
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Hernandez, Manuel E., Allon Goldberg, and Neil B. Alexander. "Decreased Muscle Strength Relates to Self-Reported Stooping, Crouching, or Kneeling Difficulty in Older Adults." Physical Therapy 90, no. 1 (2010): 67–74. http://dx.doi.org/10.2522/ptj.20090035.
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Background Bending down and kneeling are fundamental tasks of daily living, yet nearly a quarter of older adults report having difficulty performing or being unable to perform these movements. Older adults with stooping, crouching, or kneeling (SCK) difficulty have demonstrated an increased fall risk. Strength (force-generating capacity) measures may be useful for determining both SCK difficulty and fall risk. Objective The purposes of this study were: (1) to examine muscle strength differences in older adults with and without SCK difficulty and (2) to examine the relative contributions of trunk and leg muscle strength to SCK difficulty. Design This was a cross-sectional observational study. Methods Community-dwelling older adults (age [X̅±SD]=75.5±6.0 years) with SCK difficulty (n=27) or without SCK difficulty (n=21) were tested for leg and trunk strength and functional mobility. Isometric strength at the trunk, hip, knee, and ankle also was normalized by body weight and height. Results Compared with older adults with no SCK difficulty, those with SCK difficulty had significant decreases in normalized trunk extensor, knee extensor, and ankle dorsiflexor and plantar-flexor strength. In 2 separate multivariate analyses, raw ankle plantar-flexor strength (odds ratio [OR]=0.97, 95% confidence interval [CI]=0.95–0.99) and normalized knee extensor strength (OR=0.61, 95% CI=0.44–0.82) were significantly associated with SCK difficulty. Stooping, crouching, and kneeling difficulty also correlated with measures of functional balance and falls. Limitations Although muscle groups that were key to rising from SCK were examined, there are other muscle groups that may contribute to safe SCK performance. Conclusions Decreased muscle strength, particularly when normalized for body size, predicts SCK difficulty. These data emphasize the importance of strength measurement at multiple levels in predicting self-reported functional impairment.
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Borsuk-Białynicka, Magdalena. "Neogene and Quaternary paleomammalogy. Book review. A. Nadachowski, L. Werdelin (Eds.), 1996: Neogene and Quaternary mammals of the Palaearctic. 605 pp." Acta Theriologica 42 (March 10, 1997): 109–10. http://dx.doi.org/10.4098/at.arch.97-13.
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Marjuki, Marjuki. "ANALISIS PENGARUH FAKTOR-FAKTOR PENENTU KINERJA KERJA TERHADAP KINERJA KERJA SERTA DAMPAKNYA PADA PRODUKTIVITAS KERJA GURU SMK NEGERI 25, 37 DAN 47." JEBI | Jurnal Ekonomi Bisnis Indonesia 11, no. 02 (2018): 17–33. http://dx.doi.org/10.36310/jebi.v11i02.18.
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Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kepemimpinan, motivasi kerja, disiplin kerja, budaya organisasi, kepuasan kerja, dan kompensasi terhadap kinerja kerja serta dampaknya pada produktivitas kerja guru pada SMK Negeri 25, 37 dan 47. Populasi yang digunakan dalam penelitian ini adalah SMK Negeri yang terdapat di wilayah Jakarta Selatan, tetapi dalam penelitian ini penulis mengambil sampel sebanyak 200 responden yang diambil dari SMK Negeri 25, 37, dan 47. Metode penelitian menggunakan Structural Equation Modeling (SEM) dan software AMOS version 6.0. Hasil penelitian menunjukkan terdapat pengaruh yang signifikan antara disiplin kerja, budaya organisasi, kepuasan kerja terhadap kinerja kerja, dan kompensasi kerja terhadap produktivitas kerja. Dalam penelitian ini juga menunjukkan tidak terdapat pengaruh yang signifikan antara kepemimpinan, motivasi kerja, kompensasi terhadap kinerja kerja, dan tidak terdapat pengaruh yang signifikan antara kepemimpinan, kinerja guru terhadap produktivitas kerja.
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Craston, Patrick, Brad Wyble, Srivas Chennu, and Howard Bowman. "The Attentional Blink Reveals Serial Working Memory Encoding: Evidence from Virtual and Human Event-related Potentials." Journal of Cognitive Neuroscience 21, no. 3 (2009): 550–66. http://dx.doi.org/10.1162/jocn.2009.21036.
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Observers often miss a second target (T2) if it follows an identified first target item (T1) within half a second in rapid serial visual presentation (RSVP), a finding termed the attentional blink. If two targets are presented in immediate succession, however, accuracy is excellent (Lag 1 sparing). The resource sharing hypothesis proposes a dynamic distribution of resources over a time span of up to 600 msec during the attentional blink. In contrast, the ST2 model argues that working memory encoding is serial during the attentional blink and that, due to joint consolidation, Lag 1 is the only case where resources are shared. Experiment 1 investigates the P3 ERP component evoked by targets in RSVP. The results suggest that, in this context, P3 amplitude is an indication of bottom–up strength rather than a measure of cognitive resource allocation. Experiment 2, employing a two-target paradigm, suggests that T1 consolidation is not affected by the presentation of T2 during the attentional blink. However, if targets are presented in immediate succession (Lag 1 sparing), they are jointly encoded into working memory. We use the ST2 model's neural network implementation, which replicates a range of behavioral results related to the attentional blink, to generate “virtual ERPs” by summing across activation traces. We compare virtual to human ERPs and show how the results suggest a serial nature of working memory encoding as implied by the ST2 model.
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Amahoru, Nurul Musfira, Ad'dien Ad'dien, and Jamaluddin Jamaluddin. "PENINGKATAN TEKNIK LOMPAT JAUH MELALUI METODE KONVENSIONAL PADA SISWA KELAS X.TK.1 DI SMK NEGERI 6 MAKASSAR." COMPETITOR: Jurnal Pendidikan Kepelatihan Olahraga 10, no. 2 (2020): 59. http://dx.doi.org/10.26858/com.v10i2.13186.
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This study aims to improve the long jump technique through conventional methods. This research is action research. The research subjects were students of class X.TK.1 at SMK Negeri 6 Makassar, which consisted of 30 female students and the analysis technique used was qualitative descriptive analysis. Based on the results of the recapitulation between cycles after the implementation of conventional methods in the second cycle shows that the long jump technique in students of class X.TK.1 in SMK Negeri 6 Makassar has an increase, it is shown from the results in cycle I there are 6 students (20.0% ) on a scale of 4 (good) and increased to 12 students (40.0%), so that an increase of 20.0% (40.0% - 20.0%). Likewise on the value scale 3 (medium category) shows that in the first cycle there were 7 students (23.3%) and increased to 18 students (60.0%) so that there was an increase of 36.7% (60.0% - 23, 3%). Thus it can be concluded that through the conventional method carried out in the second cycle had an increase of 56.7% (20.0% + 36.7%) in the long jump technique in students of class X.TK.1 at the SMK Negeri 6 Makassar. The results of the study concluded that: there was an increase in the long jump technique through conventional methods in class X.TK.1 students at Makassar State Vocational High School 6.
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Wongso, Fery. "Perancangan Sistem Informasi Penerimaan Siswa Baru di SMK Dharma Loka Pekanbaru Berbasis Visual Basic." Jurnal Ilmu Komputer dan Bisnis 5, no. 2 (2014): 1094–110. http://dx.doi.org/10.47927/jikb.v5i2.49.
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Sekolah Menengah Kejuruan (SMK) Dharma Loka Pekanbaru adalah salah satu lembaga pendidikan yang berada dibawah naungan Yayasan Pendidikan Panca Dharma Pekanbaru. Salah satu administrasi yang dilakukan adalah pengelolaan informasi penerimaan siswa baru. Proses penerimaan siswa baru yang diterapkan di SMk Dharma Loka Pekanbaru masih bersifat manual yaitu sebatas pencatatan menggunakan buku pendaftaran dan dalam penyajian laporan tersebut penggunaan komputer hanya sebatas pengetikan seluruh data siswa yang telah dipersiapkan sebelumnya dengan menggunakan aplikasi MS-Word dan MS-Excel, sehingga di dalam menghasilkan seluruh laporan relatif lama dan kurang efisien.
 
 Dalam menyelesaikan masalah tersebut maka penulis merancang suatu sistem informasi penerimaan siswa baru menggunakan bahasa pemrograman Visual Basic 6.0, dengan database menggunakan Microsoft Access 2007, dan hasil dari laporan menggunakan Crystal Report 8.5.
 
 Dengan rancangan aplikasi tersebut diharapkan SMK Dharma Loka akan memperoleh beberapa kemudahan dalam menginput data siswa baru serta penyusunan laporan menjadi lebih cepat dan lebih efisien.
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Martini, Tini. "Pengaruh Perilaku Kepemimpinan, Motivasi Berprestasi dan Budaya Sekolah Terhadap Kinerja Guru." JURNAL ILMU MANAJEMEN DAN BISNIS 10, no. 1 (2019): 17–27. http://dx.doi.org/10.17509/jimb.v10i1.15114.
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Abstract: The purpose of this study is to analyze the behavior of leadership, achievement motivation and school culture on performance. The specific objective of this study was to analyze (1) the leadership behavior of Principal at SMK Pasundan 3 Bandung; (2) determine the achievement motivation of teachers in teaching; (3) know the culture of the school; (4) determine the teachers performance; (5) determine the effect of principal leadership behavior on teacher performance; (6) the effect of achievement motivation on teacher performance; (7) determine the effect of school culture on teacher performance; (8) the effect of leadership behavior, achievement motivation, and school culture on teacher performance. This research was conducted in area of SMK Pasundan 3 Bandung by taking the respondents 42 teachers. This Research found that leadership behavior including quite well category; achievement motivation including good category; school culture including good category; teacher performance including good category. Behavior influence leadership on teacher performance which is directly was 12.3%, indirectly through achievement motivation was 12.1%, indirectly through was 1.6%, thus the total effect was 26.0%. Achievement motivation influence on teacher performance which is directly was 27.0%, indirectly through leadership behavior was 12.1%, indirectly through school culture was 2.9%, thus the total effect was 42.0% . School culture influence performance which is directly was 6.0%, indirectly through leadership behavior was 1.6%, indirectly through achievement motivation was 2.9%, thus the total effect was 10.4%. The influence leadership behavior, achievement motivation, and school culture on teacher performance at SMK Pasundan 3 Bandung simultaneously was at 78.4%. It shows that there is a significant effect. Keywords. Abstrak: Tujuan dari penelitian ini adalah untuk menganalisis perilaku kepemimpinan, motivasi berprestasi dan budaya sekolah terhadap kinerja. Tujuan khusus penelitian ini adalah untuk menganalisis (1) perilaku kepemimpinan Kepala Sekolah SMK Pasundan 3 kota Bandung; (2) mengetahui motivasi berprestasi guru dalam mengajar; (3) mengetahui budaya sekolah; (4) mengetahui kinerja guru; (5) mengetahui pengaruh perilaku kepemimpinan kepala sekolah terhadap kinerja guru; (6) mengetahui pengaruh motivasi berprestasi terhadap kinerja guru; (7) mengetahui pengaruh budaya sekolah terhadap kinerja guru; (8) mengetahui pengaruh perilaku kepemimpinan, motivasi berprestasi dan budaya sekolah terhadap kinerja guru. Penelitian ini dilakukan di lingkungan SMK Pasundan 3 kota Bandung dengan mengambil responden 42 orang guru. Penelitian ini menemukan bahwa perilaku kepemimpinan berada dalam kategori cukup baik; motivasi berprestasi termasuk dalam kategori baik; budaya sekolah termasuk kategori baik; kinerja guru termasuk kategori baik. Pengaruh Perilaku kepemimpinan terhadap kinerja guru, yaitu pengaruh langsung 12,3%, pengaruh tidak langsung melalui motivasi berprestasi 12,1%, pengaruh tidak langsung melalui budaya sekolah 1,6%, dengan demikian pengaruh total sebesar 26,0%. Pengaruh Motivasi berprestasi terhadap kinerja guru, yaitu pengaruh langsung 27,0%, pengaruh tidak langsung melalui perilaku kepemimpinan 12,1%, pengaruh tidak langsung melalui budaya sekolah 2,9%, dengan demikian pengaruh total sebesar 42,0%. Pengaruh budaya sekolah terhadap kinerja guru, yaitu pengaruh langsung 6,0%, pengaruh tidak langsung melalui perilaku kepemimpinan 1,6%, pengaruh tidak langsung melalui motivasi berprestasi 2,9%, dengan demikian pengaruh total sebesar 10,4%. Pengaruh Perilaku kepemimpinan, motivasi berprestasi, dan budaya sekolah terhadap kinerja guru SMK Pasundan 3 kota Bandung secara simultan sebesar 78,4%. Hal tersebut menunjukkan bahwa terdapat pengaruh yang signifikan.Kata Kunci. perilaku kepemimpinan, motivasi berprestasi, budaya sekolah dan kinerja guru
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Whitaker, Thomas B., James W. Dickens, and Francis G. Giesbrecht. "Variability Associated with Determining Grade Factors and Support Price of Farmers Stock Peanuts1." Peanut Science 18, no. 2 (1991): 122–26. http://dx.doi.org/10.3146/i0095-3679-18-2-15.
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Abstract Replicated grade samples were taken from runner, Spanish, and virginia-type farmers stock peanut lots. Each sample was graded according to the procedures of the Federal State Inspection Service. The variability of % foreign material (%FM) and % loose shelled kernels (%LSK) associated with a 1800-g sample was measured. The variability of % sound mature kernels (%SMK), % sound splits (%SS), % other kernels (%OK), % damage (%DAM), and % extra large kernels (%ELK) associated with a 500-g sample was also measured. The variance was shown to be a function of the magnitude of the grade determination and was described by a relationship derived from binomial theory. From the measured grade factors, the support price per gross ton was calculated for each grade sample using the 1988 USDA loan schedule. The variance of the price per gross ton was also estimated and appeared to be independent of the price per gross ton. The coefficients of variation averaged across all lots tested were 21.1, 18.7, 2.6, 21.2, 14.0, 55.3, 7.8, and 2.4% for %FM, %LSK, %SMK, %SS, %OK, %DAM, %ELK, and price per gross ton, respectively. The computed price per gross ton of a farmers lot that has a true value of $600 was estimated to vary from $573 to $627 95% of the time when using the 500 and 1800 g grade sample to measure each grade factor.
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Conagin, Armando, Décio Barbin, and Clarice Garcia Borges Demétrio. "Modifications for the tukey test procedure and evaluation of the power and efficiency of multiple comparison procedures." Scientia Agricola 65, no. 4 (2008): 428–32. http://dx.doi.org/10.1590/s0103-90162008000400016.
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Multiple pairwise comparison tests of treatment means are of great interest in applied research. Two modifications for the Tukey test were proposed. The power of unilateral and bilateral Student, Waller-Duncan, Duncan, SNK, REGWF, REGWQ, Tukey, Bonferroni, Sidak, unilateral Dunnet statistical tests and the modified tests, Sidak, Bonferroni 1 and 2, Tukey 1 and 2, has been compared using the Monte Carlo method. Data were generated for 600 experiments with eight treatments in a randomized block design, of which 400 had four and 200 eight blocks. The differences between the treatment means in relation to the control were 30%, 20%, 15%, 10%, 5%. Two extra treatments did not differ from the control. A coefficient of variation of 10% and a probability Type I error of α = 0.05 were adopted. The power of all the tests decreased when the differences to the control, decreased. The unilateral and bilateral Student t, Waller-Duncan and Duncan tests showed greater number of significative differences, followed by unilateral Dunnett, modified Sidak, modified Bonferroni 1 and 2, modified Tukey 1, SNK, REGWF, REGWQ, modified Tukey 2, Tukey, Sidak and Bonferroni. There is great loss of efficiency for all tests in relation to the unilateral Student t test for each difference of the treatment to the control, when the differences between means decrease. The modified tests were always more efficient than their original ones.
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Meisak, Despita, Yessy Hartiwi, and Yulia Arvita. "Sistem Informasi Pengolahan Data Peserta Prakerin Pada BKK (Bursa Kerja Khusus) SMK Negeri 4 Kota Jambi)." Jurnal Ilmiah Media Sisfo 13, no. 1 (2019): 15. http://dx.doi.org/10.33998/mediasisfo.2019.13.1.411.
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BKK (Bursa Kerja Khusus) adalah sebuah mitra Dinas Tenaga Kerja dan Transmigrasi yang di bentuk oleh Sekolah Menengah Kejuruan Negeri dan Swasta, sebagai unit pelaksana yang memberikan pelayanan dan informasi lowongan pekerjaan sehingga dapat mengoptimalkan penyaluran tamatan SMK dan pencari kerja. BKK pada SMKN 4 Kota Jambi belum menggunakan sistem terkomputerisasi sehingga sering terjadi kesalahan pada saat entry data dan pelaporan memakan waktu lama. Hal ini kurang efektif dan efisien sehingga dapat mengurangi kinerja BKK untuk menyalurkan tamatan SMK dan Prakerin di dunia industri. Penelitian ini bertujuan untuk membangun sebuah sistem yang terkomputerisasi yang dapat membantu dalam pengolahan data untuk mengoptimalkan kinerja BKK menggunakan bahasa pemograman Visual Basic 6.0 dan database Ms. Acces 2007. Rancangan sistem dibuat dengan alat bantu pemodelan berorientasi objek yaitu Use Case Diagram, dan Activity Diagram.
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Sari, Arrum Fathia. "Pengaruh Kompetensi Guru Terhadap Motivasi Belajar Siswa Pada SMK Di Wilayah Serang Banten." Jurnal Ekonomi Efektif 3, no. 4 (2021): 495. http://dx.doi.org/10.32493/jee.v3i4.11287.
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Penelitian ini bertujuan untuk mengetahui pengaruh Kompetensi Guru terhadap Motivasi Belajar Siswa pada SMK di Wilayah Serang, Banten. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 98 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel Kompetensi Guru diperoleh nilai rata-rata skor sebesar 3,414 dengan kriteria baik. Variabel Motivasi Belajar Siswa diperoleh nilai rata-rata skor sebesar 3,841 dengan kriteria baik. Kompetensi Guru berpengaruh positif dan signifikan terhadap Motivasi Belajar Siswa dengan nilai persamaan regresi Y = 9,484 + 0,847X, dan nilai koefisien korelasi 0,775 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 60,0%. Uji hipotesis diperoleh signifikansi 0,000 < 0,05.Kata Kunci: Kompetensi Guru, Motivasi Belajar Siswa
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Balanovsky, Andrey E., and Van Trieu Nguyen. "Increasing Hardness of Surface Layer of Low-Carbon Steel by Account of Plasma Treatment of Coating Modification." Solid State Phenomena 316 (April 2021): 794–802. http://dx.doi.org/10.4028/www.scientific.net/ssp.316.794.
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The Purpose of paper is to conduct studies to assess the possibility of increasing the hardness of the surface layer of steel St3 grade by plasma heating of the applied surface coating containing powder alloy PR-N80X13S2R. Mixtures of pasta were divided into 2 groups: for furnace chemical-thermal treatment and plasma surface melting. The study of the microstructure showed a difference in the depth of the saturated layer, depending on the processing method, during chemical-thermal treatment-1 mm, plasma fusion - 2 mm. The results of measuring the surface micro-hardness showed that, the obtained coating from a mixture of PR-N80X13S2R + Cr2O3 + NH4Cl has a uniform high surface hardness (31-64 HRC), from a mixture of only PR-N80X13S2R - the surface hardness varies in a wide range (15-60 HRC). The study of the microhardness of the cross section of the surface layer showed that, the diffusion region: from a mixture of powder PR-N80X13S2R + Cr2O3 + NH4Cl has uniform hardness (450-490 HV); from a mixture of PR-N80X13S2R - hardness increases in the depth of the molten region (from 300 to 600 HV), and sharply decreases in the heat affected zone (210-170 HV). The use of PR-N80X13S2R alloy powder as the main component in the composition of the paste deposited on the St3 surface during plasma treatment leads to the formation of a doped surface layer with high hardness.
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Logato, Priscila Vieira Rosa, Norka da Silva Albernaz, Paula Adriane Perez Ribeiro, Rilke Tadeu Fonseca de Freitas, and Elias Tadeu Fialho. "Effect of the ration processing on the apparent digestibility values of nutrients for the piau (Leporinus elongatus)." Ciência e Agrotecnologia 33, no. 3 (2009): 890–94. http://dx.doi.org/10.1590/s1413-70542009000300032.
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The experiment carried out at National Center for Research in Tropical Fish Pirassununga, SP, aiming to determine the effect of the ration processing on the apparent digestibility coefficients of the ingredients for the piau (L. elongatus). A total of 600 males of piau were utilized, allotted into six ponds of 300L. The applied treatments were: grinder processed ration, pelleting ration and extruded ration, utilizing rations with 32% crude protein and 3400 Kcal DE.Kg-1. The experiment was in a randomized blocks design with three treatments, three blocks and two replicates. The data were submitted to variance analysis by the SAEG computational package and the means of the treatments compared by SNK test (5% of significance). The results showed that there were significant differences among the digestibility coefficients of both protein and energy for the pelleted and extrused rations (P<0.05). The results showed no statistical differences for the apparent digestibility coefficient of the dry matter (P>0.05).
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Arini, Arini, and Eis Akmeliny Fitrana. "Pengembangan Aplikasi Katalog Rumah Berbasis Augmented Reality Menggunakan Algoritma FAST." JISKA (Jurnal Informatika Sunan Kalijaga) 4, no. 1 (2019): 9. http://dx.doi.org/10.14421/jiska.2019.41-02.
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Kharia Residence merupakan perumahan yang masih menggunakan katalog 2D dalam pemasaranya, pihak developer menginginkan adanya inovasi pada media promosinya agar dapat meningkatkan minat konsumen terhadap rumah yang ditawarkan. Tujuan penelitian ini dibuat untuk mengembangkan media promosi yang menggunakan 3D dalam menvisualisasikan bangunan rumah dengan memanfaatkan tekonologi Augmented Reality pada katalog perumahanya. Metode penelitian yang digunakan dengan metode observasi, kuesioner, studi pustaka dan metode pengembangan sistem Luther. Alat bantu yang digunakan adalah unity 3D sebagai application bulider dan vuforia SDK sebagai library Augmented Reality yang didalamnya terdapat algoritma FAST Corner Detection yang diukur kedalam Star Rating disetiap markernya. Hasil akhir penelitian ini berupa aplikasi katalog home 3D. Untuk keberhasilan kemunculan objek 3D disarankan agar menggunakan spesifikasi platform dan kualitas star rating marker yang tinggi, serta berada di intensitas cahaya sedang (40 – 1000 lux) dan jarak antara marker dengan kamera AR berada disekitar 10 cm sampai 30 cm dengan sudut 600 sampai 900 . Kata Kunci : Augmented Reality, FAST Corner Detection, Star Rating, Marker, Katalog, Rumah.
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Sulaiman, Nur Fatin, Abdul Rahim Yacob, and Siew Ling Lee. "Transesterification Reaction from Rice Bran Oil to Biodiesel over Heterogeneous Base Calcium Oxide Nanoparticles Catalyst." Science and Technology Indonesia 5, no. 3 (2020): 62. http://dx.doi.org/10.26554/sti.2020.5.3.62-69.
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This research focused on the use of heterogeneous base catalyst, calcium oxide (CaO), an alkaline earth metal oxide to produce biodiesel. The aim of this research is to investigate the potential of commercial calcium carbonate, CM-CaCO3 to be transformed to nanostructured CaO and further used as a heterogeneous base catalyst for single step transesterification of rice bran oil to biodiesel. The CaO samples were calcined at temperatures of 100°C to 700°C under vacuum at 10-3 mbar. TGA-DTA result displayed that the calcination temperature for CM-CaCO3 to form CaO must be higher than 600°C. This was supported by FTIR results which indicated the complete formation of CaO at 700°C. XRD showed the rhombohedral CaCO3 and hexagonal Ca(OH)2 were totally disappeared, leaving only crystalline cubic CaO at 700oC. Interestingly, CaO obtained at 700°C (CaO-700) showed the larger BET surface area and highest basicity with 11.5 m2g-1 and 1.959 mmol/g, respectively. The prepared nanostructured CaO-700 was selected and applied for single step transesterification reaction of rice bran oil to produce biodiesel. NMR and GC-FID results further confirmed that biodiesel was successfully formed using CaO-700 as catalyst.
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Junker, Eivind. "HR-2020-1353-A («Tennisbane») ‒ første HR-sak om straff etter pbl. 2008." Kart og Plan 113, no. 03 (2020): 205–9. http://dx.doi.org/10.18261/issn.2535-6003-2020-03-05.
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Vander Lugt, Mark T., Thomas M. Braun, Samir Hanash, et al. "Plasma ST2 Concentrations Predict Development of Acute Gvhd and Non-Relapse Mortality." Blood 120, no. 21 (2012): 466. http://dx.doi.org/10.1182/blood.v120.21.466.466.
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Abstract Abstract 466 Acute graft-versus-host disease (GVHD) is a major limitation of allogeneic hematopoietic stem cell transplantation (HSCT). We previously reported that plasma concentrations of suppressor of tumorigenicity 2 (ST2) measured at the onset of GVHD therapy predicted response at day (D) 28 after therapy initiation, as well as non-relapse mortality (NRM) at 6 months after therapy. We hypothesized that ST2 measured early in HSCT would predict GVHD development by D100 and NRM at 6 months after HSCT. We first measured ST2 in plasma taken at 0, 14, and 21 days after HSCT in a pilot set of 296 patients without GVHD at D35. ST2 concentrations at D14 were most different between patients who developed GVHD and those without GVHD, and were two times higher in patients receiving full-intensity conditioning (FIC) compared to patients receiving reduced intensity conditioning (RIC). We therefore measured ST2 concentrations at D14 in two independent sets: (i) 598 patients from the University of Michigan (UM), 69% receiving FIC (85% with chemotherapy only) and 31% receiving RIC HSCT: 313 who developed GVHD between D18 and D100, and 285 without GVHD, and (ii) 75 patients from the Dana Farber Cancer Institute (DFCI), all receiving unrelated, FIC (92% receiving TBI) HSCT: 29 who developed GVHD between D18 and D100, and 46 without GVHD. UM patients who developed GVHD were older and more likely to receive mismatched or unrelated donor HSCT. Median day of GVHD onset was D35 in FIC and D42 in RIC (p=0.08). DFCI patients who received sirolimus as GVHD prophylaxis were over-represented in the no-GVHD group. Because ST2 concentrations differed between conditioning intensities, we used 3 models for prediction using the median ST2 concentrations for UM FIC, UM RIC, and DFCI TBI-based FIC as cutpoints. In multivariate analysis including the clinical characteristics of age, disease status, donor source, and HLA match, high ST2 predicted the development of GVHD in UM patients receiving FIC, but not RIC, and trended toward significance in the DFCI patient set, independent of the clinical characteristics (Hazard Ratio [HR] 1.5, p=0.004; HR 1.3, p=0.3; HR 2.0, p=0.08, respectively) (Table 1). Patients with high ST2 concentrations at D14 were also at increased risk of NRM at 6 months for all conditioning intensities independent of the clinical characteristics (UM FIC: HR 2.8, p<0.001; UM RIC: HR 4.8, p=0.005; DFCI: HR 2.6, p=0.04) (Table 1). High ST2 was not associated with increased risk of relapse mortality 1 year after HSCT (UM FIC: HR1.1, p=0.6; UM RIC: HR 0.7, p=0.6; and DFCI: HR 1.2, p=0.8). In conclusion, high ST2 concentrations early in the course of HSCT identify a group of patients at high risk for acute GVHD and NRM following HSCT. Early identification of these patients may warrant increased monitoring and potential preemptive interventions. Table 1. ST2 concentrations at D14 predict GVHD development by D100 (Top) and predict NRM at 6 months (Bottom) UM Full Intensity (n = 414) UM Reduced Intensity (n = 184) DFCI (n = 75) Univariate Multivariate Univariate Multivariate Univariate Multivariate HR p-value HR p-value HR p-value HR p-value HR p-value HR p-value Age (55 and Over vs. Under 55) 1.6 0.003 1.5 0.01 0.9 0.5 0.8 0.4 0.1 0.04 0.1 0.02 Disease Status (High vs. Low/Intermediate risk) 1.1 0.6 1.0 0.99 1.9 0.01 1.8 0.02 n/a n/a Donor (Unrelated vs. Related) 2.4 <0.001 1.9 <0.001 1.0 0.9 0.9 0.7 n/a n/a HLA match (Mismatched vs. Matched) 2.7 <0.001 2.1 <0.001 1.1 0.7 1.0 0.9 2.4 0.08 2.7 0.09 ST2 Concentration (High vs. Low)*† 1.8 <0.001 1.5 0.004 1.3 0.3 1.3 0.3 2.3 0.03 2.0 0.08 Age (55 and Over vs. Under 55) 3.5 <0.001 3.1 <0.001 0.9 0.7 0.7 0.4 0.7 0.5 0.7 0.5 Disease Status (High vs. Low/Intermediate risk) 1.4 0.1 1.1 0.6 2.8 0.02 2.7 0.02 n/a n/a Donor (Unrelated vs. Related) 1.8 0.01 1.5 0.1 1.4 0.4 1.1 0.8 n/a n/a HLA match (Mismatched vs. Matched) 21 0.004 1.7 0.06 0.6 0.4 0.5 0.3 2.0 0.2 1.9 0.2 ST2 Concentration (High vs. Low)*† 3.4 <0.001 2.8 <0.001 4.7 0.005 4.8 0.005 2.8 0.02 2.6 0.04 * Effect of ST2 calculated using regression models adjusting for age, disease status, donor, and HLA match. #x2020; High defined as ST2 concentration >600 pg/mL for UM full intensity, >300 pg/mL for UM reduced intensity, and >1660 pg/mL for DFCI. Disclosures: No relevant conflicts of interest to declare.
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Suciani, Indah, Sugeng Maryanto, and Indri Mulyasari. "HUBUNGAN PERSEN LEMAK TUBUH DAN ASUPAN ZAT BESI DENGAN KEBUGARAN JASMANI PADA REMAJA DI SMK WIDYA PRAJA UNGARAN." JURNAL GIZI DAN KESEHATAN 10, no. 23 (2018): 96–106. http://dx.doi.org/10.35473/jgk.v10i23.48.
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Latar Belakang : Kebugaran jasmani pada remaja setiap tahun menurun. Kebugaran jasmani merupaka indikator kesehatan yang penting untuk remaja karena dapat memprediksi dampak kesehatan dan berhubungan dengan peningkatan derajat kesehatan. Persen lemak tubuh yang berlebih dan asupan zat besi yang kurang merupakan salah satu faktor yang dapat mempengaruhi kebugaran jasmani pada remaja.
 Tujuan : Untuk mengetahui hubungan persen lemak tubuh dan asupan zat besi dengan kebugaran jasmani pada remaja di SMK Widya Praja Ungaran.
 Metode : Jenis penelitian ini merupakan studi kolerasi menggunakan pendekatan cross sectional di SMK Widya Praja Ungaran. Sampel sebanyak 122 siswa diambil dengan metode total sampling. Persen lemak tubuh di ukur dengan menggunakan BIA Hand to Foot electrode, asupan zat besi menggunakan FFQ semikuantitatif. Kebugaran jasmani di ukur dengan menggunakan Multistage Fitness Test. Analisis data dengan menggunakan uji kolerasi Spearman Rank (α = 0,05).
 Hasil : Rerata persen lemak tubuh responden 19,73% ± 7,28%. Rerata asupan zat besi resonden dibandingkan dengan kebutuhan sehari sebesar 47,27%, ± 31,49%. Rerata kebugaran jasmani responden 26,74 ml/kg/menit ± 6,0 ml/kg/menit. Terdapat hubungan persen lemak tubuh dan asupan zat besi dengan kebugaran jasmani (p=0,0001, p=0,0001)
 Simpulan : Ada hubungan persen lemak tubuh dan asupan zat besi dengan kebugaran jasmani pada remaja di SMK Widya Praja Ungaran.
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Rawat, Kanchan, Uttam Kumar Sahoo, Nagaraj Hegde, and Awadhesh Kumar. "Effectiveness of Neem (Azadirachta indica A. Juss) Oil against Decay Fungi." Science & Technology Journal 5, no. 1 (2017): 48–51. http://dx.doi.org/10.22232/stj.2017.05.01.06.
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The enormous use of metallic wood preservatives has caused destructive impact on environment as well as human health. Therefore realizing the urgency of switching to Environment friendly options such as natural oils are being tested for their antimicrobial properties. The present study aimed at investigating potential of Neem oil against the growth ofdecaying fungi. The ability of Neem oil to inhibit mycelia growth of Schizophyllum commune, Fusarium oxysporum, Fusarium proliferatum, Coniophora puteana and Alternaria alternata was tested at different concentrations of 0.25, 0.50, 0.75, 1.0, 2.0, 4.0, 6.0, 8.0 and 10%. Results of the study revealed Neem oil concentrations above 2% were significantly inhibitory to all the tested fungi.
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Ismail, Siti Norhayati, Nurul Shamimi Abdul Ghani, Shahril Firdaus Ab. Razak, et al. "Genetic Diversity of Pineapple (Ananas comosus) Germplasm in Malaysia Using Simple Sequence Repeat (SSR) Markers." Tropical Life Sciences Research 31, no. 3 (2020): 15–27. http://dx.doi.org/10.21315/tlsr2020.31.3.2.
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Assessments of genetic diversity have been claimed to be significantly efficient in utilising and managing resources of genetic for breeding programme. In this study, variations in genetic were observed in 65 pineapple accessions gathered from germplasm available at Malaysian Agriculture Research and Development Institute (MARDI) located in Pontian, Johor via 15 markers of simple sequence repeat (SSR). The results showed that 59 alleles appeared to range from 2.0 to 6.0 alleles with a mean of 3.9 alleles per locus, thus displaying polymorphism for all samples at a moderate level. Furthermore, the values of polymorphic information content (PIC) had been found to range between 0.104 (TsuAC035) and 0.697 (Acom_9.9), thus averaging at the value of 0.433. In addition, the expected and the observed heterozygosity of each locus seemed to vary within the ranges of 0.033 to 0.712, and from 0.033 to 0.885, along with the average values of 0.437 and 0.511, respectively. The population structure analysis via method of delta K (ΔK), along with mean of L (K) method, revealed that individuals from the germplasm could be divided into two major clusters based on genetics (K = 2), namely Group 1 and Group 2. As such, five accessions (Yankee, SRK Chalok, SCK Giant India, SC KEW5 India and SC1 Thailand) were clustered in Group 1, while the rest were clustered in Group 2. These outcomes were also supported by the dendrogram, which had been generated through the technique of unweighted pair group with arithmetic mean (UPGMA). These analyses appear to be helpful amongst breeders to maintain and to manage their collections of germplasm. Besides, the data gathered in this study can be useful for breeders to exploit the area of genetic diversity in estimating the level of heterosis.
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Ukkas, Muhammad Irwan, Heny Pratiwi, and Dessy Purnamasari. "SISTEM PENDUKUNG KEPUTUSAN PENENTUAN SUPPLIER BAHAN BANGUNAN MENGGUNAKAN METODE SMART (SIMPLE MULTI ATTRIBUTE RATING TECHNIQUE) PADA TOKO BINTANG KERAMIK JAYA." Sebatik 16, no. 1 (2016): 34–43. http://dx.doi.org/10.46984/sebatik.v16i1.73.
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Sistem Pendukung Keputusan (SPK) adalah sistem yang dapat membantu seseorang dalam mengambil keputusan yang akurat dan tepat sasaran. Banyak permasalahan yang dapat diselesaikan dengan menggunakan SPK, salah satunya adalah Penentuan Supplier Bahan Bangunan dengan menggunakan bantuan metode SMART (Simple Multi Attribute Rating Technique) Pada Toko Bintang Keramik Jaya.
 Tujuan dari penelitian ini adalah untuk menghasilkan Sistem Pendukung Keputusan Penentuan Supplier Bahan Bangunan Menggunakan Metode SMART (Simple Multi Attribute Rating Technique) Pada Toko Bintang Keramik Jaya dengan harapan seleksi Supplier secara obyektif. Dengan menggunakan bahasa pemrograman Visual Basic 6.0 dan databasenya menggunakan Microsoft Access. Dalam penelitian ini, teknik pengumpulan data yang digunakan adalah studi pustaka, observasi dan wawancara.
 Hasil dari penelitian ini adalah dibuatnya sistem pendukung keputusan untuk mengetahui Penentuan Supplier yang layak, dipertimbangkan, dan belum terpilih untuk dipilih. Pengguna dapat menginputkan data Supplier, data kriteria, data subkriteria. Kemudian sistem akan mencari solusi dengan metode SMART. Setelah keputusan didapatkan, maka sistem akan menampilkan keputusan tersebut.
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Matias-Guiu, Jordi, Jose Ferro, Jose Alvarez-Sabin, and Ferran Torres. "TRIFLUSAL VERSUS ASPIRIN IN SECONDARY STROKE PREVENTION:RESULTS OF TACIP STUDY." Stroke 32, suppl_1 (2001): 329. http://dx.doi.org/10.1161/str.32.suppl_1.329-b.
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73 TACIP was a multicentre, double-blind, randomised, parallel trial comparing the efficacy and safety of triflusal (600 mg/od) and ASA (325 mg/od) in patients who had a recent TIA or non disabling stroke. The primary end-point was the combined occurrence of non-fatal stroke, non-fatal AMI or cardiovascular death. Any of them separately was a secondary end-point, as well as total mortality, major systemic or cerebral hemorrhage and systemic thromboembolism. Forty-three centres in Spain and Portugal participated in the trial. A total of 2108 patients were evaluated with a mean follow-up of 31 months. There were no significant differences between both groups regarding to baseline characteristics. Main results were: The incidence of major and minor hemorrhages were higher in ASA than in triflusal group (24.5% vs 16.4%; p<0.001). Conclusion: Triflusal and low-dose ASA have a similar efficacy in secondary stroke prevention. Major and minor hemorrhages were significantly reduced by triflusal. Triflusal is a safer alternative to aspirin in the secondary prevention of stroke.
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Rendi Nuriawan, Danang Ari Santoso, Puji Setyaningsih, and Edi Irwanto. "Pengaruh Cahaya Lampu Terhadap Peforma Atlet Bolavoli Uniba Cup II Se-Karesidenan Besuki." SPRINTER: Jurnal Ilmu Olahraga 2, no. 1 (2021): 120–25. http://dx.doi.org/10.46838/spr.v2i1.98.
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Dalam permainan bolavoli salah satu hal yang paling berpengaruh terhadap prestasi ialah peforma. Peforma atlet dapat dipengarui oleh faktor eksternal seperti intensitas pencahayaan pada lapangan olahrga. pencahayaan dapat memberikan efek bersemangat. Tujuan dari peneltian ini adalah Untuk mengetahui pengaruh cahaya terhadap peforma atlet bolavoli. Metode yang digunakan dalam penelitian ini adalah metode penelitian eksperimen dengan pendekatan kuantitatif. Desain penelitian yang digunakan dalam penelitian ini yaitu bentuk desain studi kasus bentuk tunggal (One Shot Case Study). Populasi dalam penelitian ini adalah SMA/SMK/MA Se-Karesidenan Besuki. Teknik pengambilan sampel dalam penelitian ini adalah purposive sampling, dengan jumlah 12 tim yaitu 8 (delapan) tim putra dan 4 (empat) tim putri. Hasil penelitian menunjukan bahwa intensitas cahaya lapangan bolavoli Uniba rata-rata sebesar 365 lux. Hal ini sudah sesuia dengan Standart pencahayaan pada lapangan olahraga pada saat latihan sebesar 200 lux dan untuk pertandingan 300-600 luk. Peforma atlit peserta kejuaraan dalam kategori tinggi dengan presentase 79, 383%. Hal ini dikarenakan pencahayaan dapat memberikan efek bersemangat, depresi, membangkitkan gairah, menyejukan, mengintimidasi, memperingati, bahkan membantu merasa aman dan telindungi.
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Yulianti, Elisa, and Eko Setiawan. "IMPROVING STUDENTS’ READING COMPREHENSION THROUGH RECIPROCAL TEACHING STRATEGY ON REPORT TEXT." PROJECT (Professional Journal of English Education) 2, no. 5 (2019): 601. http://dx.doi.org/10.22460/project.v2i5.p601-607.
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The objective of this research is to know how to use of reciprocal methods to teaching reading comprehension of the senior high school in second grade. The background of the research is to help students’ to cope the difficulties in reading report text, because there are still many students who find it difficult to read English and the lack of reading comprehension of students in class XI Animation of SMK TI Garuda Nusantara Cimahi with the aim to know whether there is an increase in student scores after using the Reciprocal Learning method. The author uses the reciprocal method to increase the ability of students to read comprehension. This research is quantitative by using experimental research methods. After conducting the research obtained the data pre-test (80) and post-test (95). Based on these data, it can be concluded that the use of reciprocal methods in the report text material can improve reading comprehension in students of class XI Animation 2 Vocational School of TI Garuda Nusantara Cimahi.
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Dewi, Nadya Puspita, Tetti Solehati, and Nur Oktavia Hidayati. "KUALITAS HIDUP REMAJA YANG MENGALAMI DISMENORE DI SMK NEGERI 2 SUMEDANG." Jurnal Ilmiah Manuntung 4, no. 2 (2018): 129. http://dx.doi.org/10.51352/jim.v4i2.192.
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Dysmenorrhea is a pain before or during the menstrual period. The impact of dysmenorrhea are the disruption on physical function, emotional, social and school activities and disruption of quality of life. The study purpose is to detect the quality of life of adolescents with dysmenorrhea.The research method was a quantitative descriptive with total sampling technique to 195 students which selected using dysmenorrhea screening. The data were collected using the pediatric quality of life 4.0 generic module (PedsQL) teens report in Indonesian version which the validity and reliability have been tested. Analysis of data has been done to find out the mean value in each dimension and frequency distribution. The results showed that the mean value of the quality of life of adolescents with dysmenorrhea in general was 62,04 ± 8,15 and 51,8% was in the low. The mean value in physical dimension was 49,36 ± 9,19, emotional dimension was 57,62 ± 13,16, social dimension was 86,38 ± 13,28, and in the school dimension was 62,41 ± 14,77. The quality of life in high categories were in the emotional dimension (60,0%), social dimension (64,1%), and school dimension (60,5%). Meanwhile, the quality of life in low category was in the physical dimension (57,4%). It showed that the quality of life of adolescents with dysmenorrhea in SMK Negeri 2 Sumedang were low. It was recommended to the school and the health office in Sumedang district to provide the reproductive health education, specifically about the prevention and the treatment of dysmenorrhea on adolescents.
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Yi, Liu. "Mobile Network Application Engine Design Based on Android System." Applied Mechanics and Materials 608-609 (October 2014): 291–94. http://dx.doi.org/10.4028/www.scientific.net/amm.608-609.291.
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Along with the innovation of mobile network technology, the associated network application engine technology has also improved. In this paper, we use the JDK tools of Android system in the Eclipse environment and SDK & ADT plug-ins to design mobile application engine of Android system. And the system will be introduced to the communication terminal system. In order to verify the performance of engine system, we use the function test platform of Android system to test the mobile network application engine, and compare it with JSP engine and Java engine. By contrast, in the same network application project search, Android network will search more projects and cost less time, which verifies the advantages of the system. It provides the technical reference for the development of mobile application network system.
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Herlina, Herlina, Budi Untari, Indah Solihah, and Merie Santia. "Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil." Science and Technology Indonesia 4, no. 1 (2019): 24. http://dx.doi.org/10.26554/sti.2019.4.1.24-30.
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Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW
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Letarouilly, J. G., B. Flachaire, C. Labadie, et al. "FRI0348 PERSISTENCE OF SECUKINUMAB AND USTEKINUMAB IN PSORIATIC ARTHRITIS: A REAL-WORLD MULTICENTRIC COHORT OF 409 PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 769.2–769. http://dx.doi.org/10.1136/annrheumdis-2020-eular.746.
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Background:Real-world data are missing for Ustekinumab (UST) and secukinumab (SEK) in psoriatic arthritis (PsA).Objectives:To evaluate the characteristics of the patients (pts) with PsA treated by UST or SEK and to assess real world persistence of UST and SEK in PsA.Methods:This is a retrospective, multicenter study of pts with PsA (CASPAR criteria or diagnosis confirmed by a rheumatologist) initiating UST or SEK with a follow-up ≥ 6 months from January 2011 to April 2019. The comparison of persistence between UST and SEK was analysed using a Cox model with an inverse probability of treatment weighting propensity score including 11 confounding factors. Subgroup analyses (age>65 years, gender, Body Mass Index (BMI), Charlson score>2, psoriasis, CRP>5mg/L, number (nb) of prior biotherapies, proportion of pts on maximum dose of UST or SEK, combination with methotrexate (MTX), enthesitic and axial forms of PsA) were also performed to test the heterogeneity of UST and SEK persistence. Finally, 2 sensitivity analyses were performed, first excluding the pts treated before the marketing authorization of SEK, and then excluding the pts that underwent a molecule switch. Causes of discontinuation were also collected.Results:406 pts were included: 245 with UST and 161 with SEK. At baseline before propensity score-matching, the UST group has a higher BMI (28.9 ± 6.4 kg/m2vs. 27.4 ± 6.0 kg/m2), more peripheral forms (98% vs. 90.8%), a higher nb of active smokers (27.1% vs. 19.9%), a higher frequency of psoriasis (96.3% vs. 83.2%), less MTX users (38.9% vs. 44.2%), a higher nb of pts with CRP >5mg/L (54.3% vs. 47%), a higher nb of pts naïve to biotherapies (22% vs. 13%) and a higher nb of pts with recommended dosing (97.3% vs 50.9%). The median persistence was 9.4 months and 14.7 months for UST and SEK, respectively. The persistence rate was lower in the UST group compared to the SEK group (40.9% vs. 59.1% % at 1 year; 26.4% vs. 38.0% at 2 years; weighted HR=1.42; 95% CI 1.07 to 1.92; p=0.015) (Fig 1). In subgroup analysis, combination with MTX was associated with a higher persistence rate in the patients with SEK compared to those receiving UST: 43.6% vs. 23.2% (HR=2.20; 95% CI 1.30 to 3.51; p=0.001), whereas no difference was observed in SEK and UST monotherapy: 33.8% vs 28.4%, respectively (HR=1.06; 95% CI 0.74 to 1.53; p=0.75) (Fig 2). A similar difference was found in the sensitivity analyses, with however a difference at the limit of significance for the analysis excluding pts with a molecule switch (adjusted HR=1.35; IC95% 0.96 to 1.92; p=0.085). The causes of discontinuation were due to inefficacy in 85% of cases and an adverse event in 12% of cases (19% in the SEK group and 9% in the UST group).Conclusion:In this first real-world study comparing UST and SEK persistence in PsA, the persistence of SEK was longer than that of UST. Subgroup analysis revealed this difference of persistence was restricted to patients treated in combination with MTX.Disclosure of Interests:Jean-Guillaume Letarouilly Grant/research support from: Research grant from Pfizer, Benoît Flachaire: None declared, Céline Labadie: None declared, Nicolas Cohen Speakers bureau: Novartis, Janssen, Maeva Kyheng: None declared, Jérémie SELLAM: None declared, Pascal Richette: None declared, Philippe Dieudé: None declared, Pascal Claudepierre Speakers bureau: Janssen, Novartis, Lilly, Bruno Fautrel Grant/research support from: AbbVie, Lilly, MSD, Pfizer, Consultant of: AbbVie, Biogen, BMS, Boehringer Ingelheim, Celgene, Lilly, Janssen, Medac MSD France, Nordic Pharma, Novartis, Pfizer, Roche, Sanofi Aventis, SOBI and UCB, Eric Houvenagel Speakers bureau: Janssen, Novartis, Chi Duc Nguyen: None declared, Marie-Hélène Guyot: None declared, Nicolas Segaud: None declared, Frederic Maury: None declared, Laurent Marguerie: None declared, Xavier Deprez Speakers bureau: Novartis, Janssen, Jean-Hugues Salmon Speakers bureau: Novartis, Janssen, Guy Baudens: None declared, Corinne Miceli Richard: None declared, Elisabeth Gervais Speakers bureau: Novartis, Janssen, Roche, Pfizer, BMS, Abbvie, Isabelle CHARY VALCKENAERE: None declared, Pierre Lafforgue Speakers bureau: Novartis, Janssen, Damien LOEUILLE: None declared, Christophe Richez Consultant of: Abbvie, Amgen, Mylan, Pfizer, Sandoz and UCB., Thao Pham Speakers bureau: Novartis, Janssen, Lilly, Rene-Marc Flipo Speakers bureau: Novartis, Janssen, Lilly
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Ratain, M. J., K. L. Napoli, K. Knightley Moshier, et al. "A phase 1b study of oral rapamycin (sirolimus) in patients with advanced malignancies." Journal of Clinical Oncology 25, no. 18_suppl (2007): 3510. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.3510.
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3510 Background: Rapamycin (R) analogues are being studied as cancer therapies since mTOR is recognized as a relevant target in several cancer types. However, R is readily available, has been well-studied in organ transplant patients, was the first recognized mTOR inhibitor, and demonstrates efficacy in preclinical cancer models. The aims of this study were to define R’s maximum tolerated dose (MTD), observed toxicities, dose-limiting toxicities (DLT), pharmacokinetics and effect on inhibition of phosphorylation of p70 S6 kinase (S6K) in peripheral T-cells (PTL). Methods: R was administered orally once weekly to successive cohorts of patients using an adaptive escalation design based on whole blood concentrations ([R]), using a validated HPLC procedure. S6K was assessed by stimulating CD3+ cells ex-vivo with PMA and ionomycin for 1 hour, followed by Western blot analysis using antibodies directed against phospho-Thr389 of S6K versus total S6K as a loading control. Results: 24 subjects have been enrolled in dose cohorts of 10 mg, 20 mg, 30 mg, and 60 mg. The mean [R] observed on day 2 of week 1 (24 hr after 1st dose) was 5.5±2.7, 11.6±6.0 and 22.6±10.7 ng/mL, for dose levels 10 mg, 20 mg and 30 mg, respectively. [R] decreased by ∼50% by day 4 of week 1 (2.7±1.0, 6.9±4.0 and 11.0±7.7 ng/mL, respectively). By day 1 of week 2 (prior to the next dose of R), [R] had decreased below the limit of quantitation (2 ng/mL) for all subjects at 10 mg, 3 of 7 at 20 mg, and 4 of 6 at 30 mg. Preliminary analysis suggests that sustained phospho-S6K inhibition was achieved in some patients at 30 mg. The most common toxicities observed included nausea (50%), diarrhea (42%), asthenia (38%), hyperglycemia (58%), anemia (46%), and lymphopenia (33%). DLTs observed include 1 patient with grade 3 pneumonia at 20 mg, 1 patient with grade 3 dehydration at 30 mg, and 1 patient with grade 3 asthenia at 60 mg. Stable disease has been observed in 46% of evaluable patients. Conclusions: R can be feasibly administered orally on a once weekly schedule with a similar toxicity and pharmacokinetic profile compared with other mTOR inhibitors. Preliminary evidence suggests that prolonged suppression of phospho-S6K in PTL is possible at well-tolerated doses. No significant financial relationships to disclose.
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Devita, Maurizka Zahra, Septi Andryana, and Deny Hidayatullah. "Augmented Reality Pengenalan Huruf dan Angka Arab Menggunakan Metode Marker Based Tracking Berbasis Android." JURNAL MEDIA INFORMATIKA BUDIDARMA 4, no. 1 (2020): 14. http://dx.doi.org/10.30865/mib.v4i1.1850.
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Hijaiyah letters are Arabic letters that are in the Koran which are studied by Muslims. Number of Hijaiyah Letters which are generally known to total 30 letters. This study aims to provide an introduction hijaiyah letters, Arabic numerals and alphabets on android smartphone by applying Augmented Reality with the media guide as a marker emergence marker object so that learning becomes more attractive. From previous research, things that have been discussed are only introduces the application Augemented Reality hijaiyah and Alphabet letters using a media card with a distance of 30 cm recommendations and recommendations 600-900 corner. This application is built using the Unity 3D, Vuforia SDK with FAST Corner Detection algorithm and 3D objects created using Blender. This application uses the marker method used to determine the point of emergence of 3D objects. The results of validation testing concluded if all valid system. Testing algorithms with the point x1, y1, x2 and y2, condition of the camera to the marker on the distance is 50 cm at an angle of 450 and a distance of 50 cm - 60 cm at an angle of 900.
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Cahyadi, Decki Noor, Tenia Wahyuningrum, and Irwan Susanto. "Rancang Bangun Sistem Presensi Mahasiswa Berbasis Fingerprint Client Server." JURNAL INFOTEL - Informatika Telekomunikasi Elektronika 6, no. 1 (2014): 43. http://dx.doi.org/10.20895/infotel.v6i1.15.
Full textAbstract:
Presensi mahasiswa merupakan salah satu peran penting dalam kegiatan belajar dan mengajar. Sistem Presensi melalui SIMAK di ST3 Telkom memiliki beberapa kekurangan, yaitu memerlukan waktu khusus untuk memanggil mahasiswa satu persatu, juga memiliki celah kecurangan, jika dosen yang bersangkutan tidak mengenali wajah mahasiswa, sehingga ada kemungkinan mahasiswa mengaku sebagai mahasiswa lain. Berdasarkan hasil analisa, ditawarkan sebuah inovasi baru untuk Sistem Presensi menggunakan fingerprint berbasis client server. Dalam pembangunan Sistem Presensi ini menggunakan metode pengembangan sistem waterfall, DBMS Microsoft Access dan Visual Basic 6.0 sebagai bahasa pemrogramannya. Hasil pengujian menunjukkan sistem informasi presensi sudah dapat berjalan dengan baik. Output sesuai dengan rancangan yang telah dibuat.