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Journal articles on the topic 'Stock vs flow'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Piątkowski, Paweł. "STOCK FLOW ADJUSTMENT VS. STABILITY OF POLISH PUBLIC DEBT." PRACE NAUKOWE UNIWERSYTETU EKONOMICZNEGO WE WROCŁAWIU, no. 521 (2018): 131–40. http://dx.doi.org/10.15611/pn.2018.521.13.

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Endriani, Santi. "Konsep Uang: Ekonomi Islam VS Ekonomi Konvensional." Anterior Jurnal 15, no. 1 (2015): 70–75. http://dx.doi.org/10.33084/anterior.v15i1.201.

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In Islamic economics, the concept of money is very clear that money is a medium of exchange in muamalah, instead of capital (commodities). That money is objected that are approved by the public as an intermediary tool to hold the exchange or trade. Differences concept of money in Islamic and conventional economics are on the money that is not identical to the capital, the money is public goods, capital is private goods, money is a flow concept, and capital is a stock concept in the concept of money in Islam. While the conventional concept of money in the currency identified with capital money

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Naufal Khadaf. "KETIDAKSTABILAN INFLASI VS GEJOLAK SAHAM: DINAMIKA ICBP DI PANDEMI COVID-19 TAHUN 2020 - 2023." Jurnal Ekonomi, Bisnis dan Pendidikan 4, no. 7 (2024): 3. https://doi.org/10.17977/um066v4i72024p3.

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AbstractThis study analyzes the relationship between inflation volatility and stock pricevolatility of PT Indofood CBP Sukses Makmur Tbk (ICBP) during the COVID-19pandemic (2020-2023). ICBP, a major player in Indonesia's consumer goodssector, faced significant economic fluctuations due to global instability duringthe pandemic. Using secondary data from monthly inflation rates and ICBPstock prices, the research employs the Jarque-Bera normality test for datavalidation and the Pearson correlation test to examine the relationshipbetween the two variables. The results show a significant negative c

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MATTIUCCI, S., R. CIMMARUTA, P. CIPRIANI, P. ABAUNZA, B. BELLISARIO, and G. NASCETTI. "Integrating Anisakis spp. parasites data and host genetic structure in the frame of a holistic approach for stock identification of selected Mediterranean Sea fish species." Parasitology 142, no. 1 (2014): 90–108. http://dx.doi.org/10.1017/s0031182014001103.

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SUMMARYThe unique environment of the Mediterranean Sea makes fish stock assessment a major challenge. Stock identification of Mediterranean fisheries has been based mostly from data on biology, morphometrics, artificial tags, otolith shape and fish genetics, with less effort on the use of parasites as biomarkers. Here we use some case studies comparing Mediterranean vs Atlantic fish stocks in a multidisciplinary framework. The generalized Procrustes Rotation (PR) was used to assess the association between host genetics and larval Anisakis spp. datasets on demersal (hake) and pelagic (horse mac

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Fikri, M. Ali, Biana Adha Inapty, and Baiq Rosyida Dwi Astuti. "Direct Current (DC) vs Alternating Current (AC) Financial Transaction Flow in Holding and Non-Holding Companies." Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram 10, no. 2 (2022): 352. http://dx.doi.org/10.33394/j-ps.v10i2.5090.

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A study on the flow of financial transactions needs to be carried out considering that activities in the financial sector require quick and relevant decisions. The flow of financial transactions in the business world is almost similar to direct current (DC) and alternating current (AC). The phenomenon is that many business people want their funds to be spread outside the company, and some want their funds to only revolve around the company. This study tries to analyze the results of investment flows of funds outside the company and within the company in the scope of the Indonesian capital mark

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Laoh, Lidya Chitra. "Dividend Payout Forecast : Multiple Linear Regression vs Genetic Algorithm-Neural Network." CogITo Smart Journal 5, no. 2 (2019): 252. http://dx.doi.org/10.31154/cogito.v5i2.210.252-265.

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This research aims to compare two methods of forecasting, i.e Multiple Linear Regression (MLR) and Genetic Algorithm-Neural Network (GA-NN), in forecasting dividend payout of Indonesian manufacturing company listed on Indonesia Stock Exchange from 2010-2014. Having collected 1384 firm-year observations, the result shows that these two methods could be used to predict dividend payout by considering earnings, free cash flow, growth opportunity, leverage, liquidity and size. This resesarch finds that even though both methods are powerful in prediction, yet in this case, MLR outperforms GA-NN. Key

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Vassallo, Paolo, Claudia Turcato, Ilaria Rigo, et al. "Biophysical Accounting of Forests’ Value under Different Management Regimes: Conservation vs. Exploitation." Sustainability 13, no. 9 (2021): 4638. http://dx.doi.org/10.3390/su13094638.

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Forest ecosystems are important providers of ecosystem functions and services belonging to four categories: supporting, provisioning, regulating and cultural ecosystem services. Forest management, generally focused on timber production, has consequences on the ability of the system to keep providing services. Silviculture, in fact, may affect the ecological structures and processes from which services arise. In particular, the removal of biomass causes a radical change in the stocks and flows of energy characterizing the system. Aiming at the assessment of differences in stored natural capital

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Senarathne, Chamil W., and Jianguo Wei. "The impact of patent citation information flow regarding economic innovation on common stock returns: Volume vs. patent citations." International Journal of Innovation Studies 2, no. 4 (2018): 137–52. http://dx.doi.org/10.1016/j.ijis.2019.02.001.

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Berthelsen, Chris. "Distributed Resource Centre: A Soft Infrastructure for Neighbourhood Creativity." Asylum 1 (November 22, 2023): 3–12. http://dx.doi.org/10.34074/aslm.2023102.

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This article presents the Distributed Resource Centre as a soft, low-cost, generative, and fun decentralised infrastructure for neighbourhood creativity. The article defines the concept (as flow vs stock), outlines some broad benefits (increased interfaces and resource availability, fostering of creative capability, and cost reductions), discusses the pilot and development projects which were involved in the development of the concept, and presents tentative findings for further exploration and discussion (making friends, porous, asynchronous and uncertain activity, neighbourhood = resource ce

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10

Kirchmeier, Delaney R., Alyssa Sheih, Salvatore Fiorenza, et al. "Recombinant CD19 Glycomutant Accurately and Reproducibly Detects CD19-Directed CAR-T Cells By Flow Cytometry." Blood 138, Supplement 1 (2021): 1724. http://dx.doi.org/10.1182/blood-2021-148229.

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Abstract Background CD19-directed chimeric antigen receptor (CAR)-modified T cell therapy expansion and persistence in peripheral blood has been shown to correlate with responses against B cell malignances (Hay, Blood, 2018; Ayuk, Blood Adv, 2021). CAR-T cell enumeration is typically achieved through quantitative PCR (qPCR) or flow cytometry (FC). qPCR, however, requires techniques that may not be locally validated and, unlike FC, cannot simultaneously address T cell immunophenotype. Existing FC reagents to detect CD19 CAR-T cells are mostly specific for a given CAR sequence or bind non-specif

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Ma’arif, Oktaviano Miftahqul, and Tatit Kurniasih. "Perancangan Sistem Inventory Berbasis Web Menggunakan Framework Flask : PT. Gagas Mitra Jaya (Area Salatiga)." Jurnal Indonesia : Manajemen Informatika dan Komunikasi 5, no. 2 (2024): 1947–59. http://dx.doi.org/10.35870/jimik.v5i2.822.

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Research was conducted to build web-based inventory system at PT. Gagas Mitra Jaya in Salatiga as solution to the challenges in process of recording materials owned by technician. The research method used hybrid waterfall-agile. System design uses use case and activity diagrams in UML to describe flow of system creation, which involves the process of collecting data through interviews and questionnaires. The development uses Python, Flask, VS Code IDE, and PostgreSQL. This selection based on considerations of flexibility, accessibility, ease of integration, and faster update capabilities. The

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Wu, Yaxuan, Dianrong Sun, Liangming Wang, et al. "Genetic Impacts of Sustained Stock Enhancement on Wild Populations: A Case Study of Penaeus penicillatus in the Beibu Gulf, China." Diversity 17, no. 8 (2025): 511. https://doi.org/10.3390/d17080511.

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In recent decades, fishery stock enhancement has been increasingly utilized as a restoration tool to mitigate population declines and enhance the resilience of marine fisheries. Nevertheless, persistent enhancement efforts risk eroding the evolutionary potential of wild populations via genetic homogenization and maladaptive gene flow. Using long-term monitoring data (2017–2023), we quantified the effects of large-scale Penaeus penicillatus stock enhancement (~108 juveniles/yr) on wild population dynamics and genetic integrity in the Beibu Gulf ecosystem. Temporal genetic changes were assessed

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Rubic-Schneider, Tina, Prithu Sundd, David Ledieu, et al. "Characterization of Two Anti-P-Selectin Monoclonal Antibodies (mAbs): Crizanlizumab Shows Comparable or Stronger Effects Versus Inclacumab across Cell Adhesion Assays in Vitro." Blood 138, Supplement 1 (2021): 2032. http://dx.doi.org/10.1182/blood-2021-147318.

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Abstract Background: Vaso-occlusive crises (VOCs) are the hallmark of sickle cell disease (SCD) and are associated with significant morbidity and mortality. Crizanlizumab, a first-in-class humanized anti-P-selectin IgG2 mAb, is approved in &gt;40 countries to reduce/prevent VOCs in SCD patients aged ≥16 yrs. Inclacumab, a fully human anti-P-selectin IgG4 mAb, is in clinical development for SCD. In vitro data suggest that inclacumab may show stronger affinity to P-selectin and greater maximal inhibition of cell-cell interactions vs crizanlizumab (Geng et al ASH 2020). Aim: We investigated i

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Friedman, J. J. "Vascular sensitivity and reactivity to norepinephrine in diabetes mellitus." American Journal of Physiology-Heart and Circulatory Physiology 256, no. 4 (1989): H1134—H1138. http://dx.doi.org/10.1152/ajpheart.1989.256.4.h1134.

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Vascular sensitivity (VS) and reactivity (VR) of hindquarters, totally isolated from rats made diabetic with 45 mg/kg of streptozotocin (STZ), were determined at 1, 2, 4, 8, and 12 wk post-STZ. Age-matched controls received saline injections and were followed for comparable periods. The hindquarters were perfused at constant flow (8-10 ml/min) with a Tyrode-perfluorocarbon (FC-43)albumin-alpha-globulin solution gassed with 95% O2-5% CO2. Tissues were continuously weighed and venous pressure adjusted to maintain an isogravimetric condition. VS and VR were determined from norepinephrine (NE) dos

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Mendiola, Vincent Louie Ramos, Catherine Ly, Thuy Bui, et al. "Superior Outcomes in Hispanic Patients Compared to Non-Hispanic Patients with Ph-Negative Acute Lymphoblastic Leukemia Using the Modified Pediatric-Based University of Southern California Acute Lymphoblastic Leukemia (USC ALL) Regimen for Newly Diagnosed ALL Patients in the Era of Novel Agents; A Retrospective Study." Blood 138, Supplement 1 (2021): 3361. http://dx.doi.org/10.1182/blood-2021-150116.

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Abstract INTRODUCTION: Hispanic patients with acute lymphoblastic leukemia (ALL) are historically known to have poor outcomes compared to non-Hispanic patients. Our institution, LAC-USC (LA County Hospital/University of Southern California) has shown a complete remission rate of 96% with use of pegasparagase at 2000 IU/m2 using the USC ALL regimen (based on CCG-1882) for patients aged 17-55 years with a 7-year OS of 51% reported in 2014. The modified USC ALL regimen now uses a single dose of cytarabine rather than fractionated doses and uses a single dose 3g/m 2 methotrexate compared to 1g/m 2

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Johnson, Ned K., and Jill A. Marten. "Evolutionary Genetics of Flycatchers. II. Differentiation in the Empidonax difficilis Complex." Auk 105, no. 1 (1988): 177–91. http://dx.doi.org/10.1093/auk/105.1.177.

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Abstract We used starch-gel electrophoresis to assess variability at 41 genetic loci in 208 individuals from 11 breeding populations of the Western Flycatcher (Empidonax difficilis) complex. Genic variability was substantial in most populations and equivalent to levels found in other avian taxa. A sample of E. d. insulicola from Santa Catalina Island, however, showed reduced heterozygosity and an unusually low percentage of polymorphic loci. We attribute this to a bottleneck at the time of the original colonization. Nei's genetic distances among populations of one taxon ranged from D̄ = 0.0003

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Buda, Rocco, Chiara Bedon, and Raffaele Pucinotti. "Retrofit of Existing Reinforced Concrete (RC) Buildings: Steel vs. RC Exoskeletons." Applied Sciences 12, no. 22 (2022): 11511. http://dx.doi.org/10.3390/app122211511.

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The existing building stock is largely made up of reinforced concrete (RC) buildings, constructed between the post-World War II period and 1981, and mostly consists of buildings constructed very quickly to meet the great housing demand of this period, and buildings that do not adhere to anti-seismic and energy regulations. Today, after more than fifty years, these buildings have reached the end of their useful life cycle and their maintenance is not sustainable, presenting a series of structural, energy and architectural problems and criticalities. The myriad of possible retrofit interventions

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Ungfors, Anette, Niall J. McKeown, Paul W. Shaw, and Carl André. "Lack of spatial genetic variation in the edible crab (Cancer pagurus) in the Kattegat–Skagerrak area." ICES Journal of Marine Science 66, no. 3 (2009): 462–69. http://dx.doi.org/10.1093/icesjms/fsn223.

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Abstract Ungfors, A., McKeown, N. J., Shaw, P. W., and André, C. 2009. Lack of spatial genetic variation in the edible crab (Cancer pagurus) in the Kattegat–Skagerrak area. – ICES Journal of Marine Science, 66: 462–469. The stock structure of the edible crab (Cancer pagurus L.) in the Kattegat and Skagerrak was investigated using eight microsatellite DNA loci. Replicate samples, collected 4–6 years apart, were derived from the Kattegat (Grove Bank, 57°N) and the Skagerrak (Lunneviken, 59°N), plus a geographical outgroup sample from the Norwegian Sea (Midsund, 62°N). Genetic differentiation amo

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Ghorani, E., J. Reading, J. Henry, et al. "P03.30 Tumur mutations drive dysfunctional T cell differentiation in lung cancer." Journal for ImmunoTherapy of Cancer 8, Suppl 2 (2020): A35.1—A35. http://dx.doi.org/10.1136/jitc-2020-itoc7.68.

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BackgroundEffective anti-tumour immunity requires cancer antigen expression, but persistent antigen exposure in chronic viral infections and autoimmunity has a detrimental effect on immune function. This is associated with a decline of early differentiated T cell populations in favour of later differentiated, dysfunctional subsets, resulting in an unfavourable skewing of the immune landscape. It is unknown whether this occurs locally within the antigen rich tumour microenvironment, driving immune failure.Materials and MethodsWe combined tumour infiltrating lymphocyte (TIL) high dimensional flo

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Claessen, David, Anneke S. de Vos, and André M. de Roos. "Bioenergetics, overcompensation, and the source–sink status of marine reserves." Canadian Journal of Fisheries and Aquatic Sciences 66, no. 7 (2009): 1059–71. http://dx.doi.org/10.1139/f09-061.

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One of the hypothesized functions of marine protected areas (MPAs) is to serve as sources of biomass, with biomass spilling over from the reserve into neighbouring, harvested areas. We argue that the net larval flow (from or to the marine reserve) depends on between-area differences in the population-level biomass production rate, whereas the direction of adult flow depends on differences in the biomass standing stock. Hence, an important question is whether population-level biomass production increases (overcompensation) or decreases (undercompensation) with increased per capita mortality. We

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Mendiola, Vincent Louie Ramos, Catherine Ly, Thuy Bui, et al. "Outcomes in Adult Philadelphia-Positive Acute Lymphoblastic Leukemia Patients Using Tyrosine Kinase Inhibitors Combined with the Modified University of Southern California (USC ALL) Regimen without Pegaspargase in the Era of Novel Agents; A Retrospective Study." Blood 138, Supplement 1 (2021): 4372. http://dx.doi.org/10.1182/blood-2021-150135.

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Abstract Introduction: Prior to the introduction of tyrosine kinase inhibitors (TKIs), the presence of BCR-ABL1 conferred a poor prognosis in patients with acute lymphoblastic leukemia (ALL). We published in 2017 in Br J Haematology our analysis comparing the survival of Ph-Positive (Ph+) and Ph-negative ALL during the period when TKIs were universally available in the United States for Ph+ ALL using a Surveillance, Epidemiology, and End Results (SEER) Database analysis. Despite using TKIs, we have continued to remain reliant on cytotoxic chemotherapy regimens and allogeneic hematopoietic stem

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Hirayama, Alexandre V., Ye Zheng, Mark R. Dowling, et al. "Long-Term Follow-up and Single-Cell Multiomics Characteristics of Infusion Products in Patients with Chronic Lymphocytic Leukemia Treated with CD19 CAR-T Cells." Blood 138, Supplement 1 (2021): 1749. http://dx.doi.org/10.1182/blood-2021-151571.

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Abstract Introduction Lymphodepletion chemotherapy followed by infusion of autologous T cells engineered to express a CD19-targeted chimeric antigen receptor (CAR) has shown high response rates in relapsed or refractory high-risk chronic lymphocytic leukemia (CLL). Durable remissions were observed, particularly in patients (pts) who achieved minimal residual disease (MRD)-negative (neg) complete response (CR) in the marrow with no detectable malignant clone by IGH sequencing. Here, we present long-term outcomes of CLL pts treated with CD19 CAR-T cell immunotherapy, and single-cell cellular ind

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Kreitman, Robert J., Evgeny Arons, Sapolsky Jeffrey, et al. "Resolution of Hairy Cell Leukemia Minimal Residual Disease by Both BRAF and Clone-Specific Real-Time Quantitative PCR (RQ-PCR) After Treatment with Moxetumomab Pasudotox." Blood 120, no. 21 (2012): 2896. http://dx.doi.org/10.1182/blood.v120.21.2896.2896.

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Abstract Abstract 2896 Background: Moxetumomab pasudotox is an anti-CD22 recombinant immunotoxin containing truncated Pseudomonas exotoxin which was recently reported to achieve a complete remission rate of 46% in 28 patients with relapsed/refractory hairy cell leukemia (HCL). An additional 20 patients were treated at the highest dose level and are now fully evaluable for response and minimal residual disease (MRD) determinations. RQ-PCR using clone-specific primers and a clone-specific TaqMan probe is capable of detecting one HCL cell in 106normal cells. Recently reported methods to detect th

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White, Susan. "Amazon and Whole Foods: adventures in grocery shopping." CASE Journal 16, no. 2 (2020): 115–53. http://dx.doi.org/10.1108/tcj-11-2018-0118.

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Theoretical basis This case focuses on valuation using various methods to price a firm. Students attempting this case should know the basics of how to value a company using discounted cash flow, comparable multiples and comparable transactions. Students will need to calculate the weighted average cost of capital using comparable companies and the capital asset pricing model and determine differences in value created by an acquisition vs a leveraged buyout (LBO). The case also discusses qualitative issues in mergers, such as fit between target and acquirer, integration issues, potential high de

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Chadha, Saurabh, and Anil K. Sharma. "Determinants of capital structure: an empirical evaluation from India." Journal of Advances in Management Research 12, no. 1 (2015): 3–14. http://dx.doi.org/10.1108/jamr-08-2014-0051.

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Purpose – The purpose of this paper is to study the key determinants of capital structure for Indian manufacturing firms and which theory implications, i.e. trade off vs pecking order are more applicable in current Indian manufacturing sector scenario. Design/methodology/approach – A sample size of 422 listed Indian manufacturing companies on Bombay Stock Exchange has been considered to do the empirical evaluation. A ten year period from 2003-2004 to 2012-2013 and annual financial standalone data have been considered for study. Ratio analysis and panel data approach have been applied to perfor

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Jesuraj, Nithya J., Julie M. Cole, Felipe Bedoya, et al. "A Novel Phase-Change Hydrogel Substrate for T Cell Activation Promotes Increased Expansion of CD8+ Cells Expressing Central Memory and Naive Phenotype Markers." Blood 128, no. 22 (2016): 3368. http://dx.doi.org/10.1182/blood.v128.22.3368.3368.

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Abstract Introduction For chimeric antigen receptor T cell-based (CAR-T) and engineered T cell receptor (TCR) immunotherapies, T cell expansion methods and phenotype/s of transplanted T cells may heavily influence clinical outcomes. Much current focus is on the potential of defined CD4+/CD8+ T cell populations vs bulk, and on the potential superiority of CAR-T cells from naïve (TN) or central memory (TCM) versus effector memory (TEM) cells. Many commercial T cell activation and expansion methods utilize rigid magnetic beads bound to antibodies against CD3 and CD28 as substrates. These methods

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Fidai, Shiraz, Madina Sukhanova, Brian C. H. Chiu, et al. "TP53 Aberrations By FISH in CLL and Complex Karyotype at Transformation Predict for Worse Outcome in Diffuse Large B-Cell Lymphoma - Richter Transformation: A Single Institution Series of 75 DLBCL-RT Cases." Blood 132, Supplement 1 (2018): 2984. http://dx.doi.org/10.1182/blood-2018-99-112242.

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Abstract Background: Richter transformation (RT), also known as Richter syndrome, is a rare complication of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that has an aggressive clinical course and unfavorable prognosis. The majority of these transformations occur in the form of diffuse large B-cell lymphoma (DLBCL), and less frequently in the form of prolymphocytic leukemia (PLL), or classical Hodgkin lymphoma (cHL). We examined a series of RT cases with available CLL/SLL data diagnosed at our institution between 2000 and 2018 to identify clinical/biologic characteristics

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P., Afsheena, and Shijin Santhakumar. "Timeliness and persistence of conservative earnings in an emerging market." Journal of Financial Reporting and Accounting 18, no. 3 (2020): 483–503. http://dx.doi.org/10.1108/jfra-12-2018-0116.

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Purpose The asymmetric effect of conservatism on earnings and its other components serves as a contrivance to incorporate transparency and timeliness in financial reporting. This study aims to explore cash flow-return association, which provides insight into the accruals’ contribution that traverses through conservatism-earnings persistence liaison and its associated effects on stock returns. Design/methodology/approach The study used asymmetric timeliness (AT) model and two firm-year measures, namely, C-Score and conservatism ratio, to capture conservatism. The firm-year measures of conservat

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Karol, Seth E., Thomas Alexander, Amit Budraja, et al. "Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 178. http://dx.doi.org/10.1182/blood-2019-127716.

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Introduction: Venetoclax (VEN) is a potent and selective inhibitor of BCL-2. It has demonstrated activity in adults with acute myeloid leukemia (AML) in combination with low-dose cytarabine (&lt;100mg/m2/day) and hypomethylating agents. Here, we report safety and activity of VEN in combination with intermediate- and high-dose cytarabine with or without idarubicin in children and young adults with relapsed or refractory AML. Methods: VEN was given daily for 28 days and chemotherapy was started on day 8, or earlier in cases of disease progression. Dosages of VEN and chemotherapy were escalat

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Dorigatti Borges, Marina, Dulcineia Albuquerque, Carolina Lanaro, et al. "Erythrophagocytosis Mediated By Circulating Monocytes Is Induced By Distinct Mechanisms Depending on the Disease." Blood 142, Supplement 1 (2023): 2454. http://dx.doi.org/10.1182/blood-2023-189370.

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Stress erythropoiesis (SE) occurs when the steady state erythropoiesis is no longer sufficient to sustain the number of healthy red blood cells (RBC) needed in the circulation. There is an extension of this activity to extramedullary sites, contributing to the increase in cell production in the erythroblastic island (EBI) niche, and altered or damaged RBCs are then cleared by macrophages. Some diseases have a state of chronic SE. Sickle cell anemia (SCA) affects multiple aspects of RBCs, leading to recurrent vaso-occlusive crisis, hemolytic anemia, and inflammation. Polycythemia Vera (PV), an

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Zeidan, Amer M., Jan Philipp Philipp Bewersdorf, Vanessa Hasle, et al. "Immune and Epigenetic Landscape of TP53-mutated Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes (HR-MDS)." Blood 138, Supplement 1 (2021): 3371. http://dx.doi.org/10.1182/blood-2021-146329.

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Abstract Introduction: Mutations in TP53 occur in 10% of patients (pts) with AML and HR-MDS and have been associated with worse outcomes and an immunosuppressive phenotype. To define the immune and epigenetic landscape in TP53-M advanced myeloid neoplasms (MN), we compared data from 61 pts with HR-MDS or AML with TP53 mutations (TP53-M) to 143 TP53 wildtype (TP53-WT) pts who were followed prospectively with serial samples in a well-annotated clinical trial in which all pts received hypomethylating agent (HMA)-based therapy. Methods: The FUSION trial (NCT02775903) was a large, randomized phase

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Soumerai, Jacob D., Anthony R. Mato, Ahmet Dogan, et al. "Zanubrutinib, Obinutuzumab, and Venetoclax in Chronic Lymphocytic Leukemia: Early MRD Kinetics Define a High-Risk Patient Cohort with Delayed Bone Marrow Undetectable MRD and Earlier Post-Treatment MRD Recurrence." Blood 138, Supplement 1 (2021): 3753. http://dx.doi.org/10.1182/blood-2021-150961.

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Abstract Background: Venetoclax (Ven; BH3 mimetic) and Obinutuzumab (O; CD20 antibody) is an approved, fixed-duration regimen (one year) that induces undetectable minimum residual disease (uMRD) and durable remissions in treatment naïve patients (pts) with chronic lymphocytic leukemia (CLL; Fischer NEJM 2019). In the CLARITY trial of venetoclax-ibrutinib (BTK inhibitor; BTKi) in relapsed or refractory CLL, peripheral blood (PB) MRD response kinetics predicted bone marrow (BM) uMRD and were associated with progression-free survival (Rawstron EHA 2020). We explored MRD as a biomarker to direct t

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Hidalgo-Lopez, Juliana E., Gail J. Roboz, Brent Wood, et al. "Heterogeneity of Minimal/Measurable Residual Disease (MRD) Practices in Adult B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in the United States." Blood 138, Supplement 1 (2021): 4478. http://dx.doi.org/10.1182/blood-2021-144353.

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Abstract Background: MRD testing in BCP-ALL is critical for appropriate patient management, but little is known regarding sample acquisition and testing heterogeneity across clinical practice settings. These factors may impact the quality and reliability of MRD assessment. Methods: Thirty-minute online surveys were conducted in May 2021 with hematologists/oncologists (HEME/ONCs) in the United States in both academic (acad) and community (comm) settings. Respondents were licensed physicians board certified in oncology and/or hematology who treated ≥2 BCP-ALL patients/year or ≥10 patients in the

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Nastiti, Pambayun Kinasih Yekti, Apriani Dorkas Rambu Atahau, and Supramono Supramono. "THE DETERMINANTS OF WORKING CAPITAL MANAGEMENT: THE CONTEXTUAL ROLE OF ENTERPRISE SIZE AND ENTERPRISE AGE." Business, Management and Education 17, no. 2 (2019): 94–110. http://dx.doi.org/10.3846/bme.2019.10409.

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Purpose – working capital management plays a vital role in determining the continuity of enterprises’ business activities. Enterprises should manage their working capital efficiently to avoid excessive working capital investments and at the same time, to maintain their liquidity. This study aims to examine the determinants of working capital management and to test the different effects of the determinants of working capital management based on enterprise size and enterprise age. Research methodology – the sample consists of 117 manufacturing enterprises listed at the Indonesian Stock Exchange

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Alhumaid, Muhned, Georgina S. Daher-Reyes, Aaron D. Schimmer, et al. "Prognostic Role of Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in Patients with Acute Myeloid Leukemia Harboring DNMT3A/TET2/ASXL1 Mutation." Blood 136, Supplement 1 (2020): 8–9. http://dx.doi.org/10.1182/blood-2020-138862.

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BACKGROUND: Multiparameter flow cytometry (MFC) has increasingly been used for measurable residual disease (MRD) assessment in patients with acute myeloid leukemia (AML), while next-generation sequencing (NGS)-based MRD monitoring tool is in clinical development for its application. Clonal hematopoiesis (CH), in which leukemia-associated somatic mutations gene are present in individuals with no apparent hematologic disease, adds a challenge in the detection of MRD. In patients with AML, CH could be potentially pre-leukemic, while persistent mutations in DNMT3A, TET2 orASXL1 (DTA) in remission

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Murphy, Tracy, Stanley W. K. Ng, Ian King, et al. "Inferior Outcomes with a High LSC17 Score Can be Improved with Flag-IDA." Blood 136, Supplement 1 (2020): 35–36. http://dx.doi.org/10.1182/blood-2020-138943.

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Introduction: Acute myeloid leukemia (AML) is driven by a subpopulation of leukemia stem cells (LSCs), which possess properties such as quiescence and self-renewal that are linked to therapy resistance and relapse. The LSC17 score was derived from genes differentially expressed between functionally validated LSC+ and LSC- fractions from 78 AML patients and is strongly associated with survival and response to standard therapy. A critical advantage of the LSC17 test over cytogenetic and molecular analysis is its rapid turnaround time (24-48h on a NanoString platform), providing clinicians with a

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Kantarjian, Hagop M., Wendy Stock, Ryan D. Cassaday, et al. "Efficacy and Safety Outcomes in the Phase 3 INO-Vate Trial By Baseline CD22 Positivity Assessed By Local Laboratories." Blood 134, Supplement_1 (2019): 1344. http://dx.doi.org/10.1182/blood-2019-122097.

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Introduction: Inotuzumab ozogamicin (InO) is a CD22-directed antibody-calicheamicin conjugate. Patients (pts) with relapsed or refractory (R/R) B cell acute lymphoblastic leukemia (ALL) treated with InO vs standard of care chemotherapy (SC) had significantly better response, and improved survival in INO-VATE (NCT01564784). Based on central laboratory assessment, this favorable benefit-risk profile of InO was independent of leukemic blast CD22 positivity (≥90% vs &lt;90%) and CD22 receptor density (quantified as Molecules of Equivalent Soluble Fluorochrome, quartile analysis). As CD22 is us

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Kucukal, Erdem, Aaron Wolfe, Ryan Kocevar, et al. "Hypoxic Storage of Red Blood Cells: Assessment of Adhesion Properties Using a Standardized Endothelium-on-a-Chip Microfluidic Platform." Blood 138, Supplement 1 (2021): 1072. http://dx.doi.org/10.1182/blood-2021-151270.

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Abstract Background: Blood transfusions are routine medical procedures in which stored blood or blood products (i.e., red blood cells, RBCs) are given to the patient to prevent adverse health outcomes due to acute or chronic anemia. The current regulations require RBCs to be stored at 4 ºC not more than 42 days before a transfusion. However, RBCs undergo extensive rheological changes during storage and may contribute to complications associated with transfusion. Hemanext has recently introduced an innovative storage system to ameliorate such storage lesions, in which RBCs are stored in a hypox

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Yilmaz, Musa, Hagop Kantarjian, Nicholas J. Short, et al. "Hypomethylating Agent (HMA) Therapy and Venetoclax (VEN) with FLT3 Inhibitor "Triplet" Therapy Is Highly Active in Older/Unfit Patients with FLT3 Mutated AML." Blood 138, Supplement 1 (2021): 798. http://dx.doi.org/10.1182/blood-2021-154143.

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Abstract Introduction Internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations (m) in FLT3 occur in about 30% of the patients (pts) with newly diagnosed AML. FLT3m are associated with a higher risk of relapse and inferior overall survival (OS). Outcomes remain poor in older/unfit pts with FLT3m AML; with expected median OS of 8-12 months with combinations of low intensity chemotherapy (LIC) with FLT3 inhibitors (FLT3i) or with venetoclax (VEN) [Ohanian et al. AJH, 2018; Konopleva et. al. ASH, 2020). In this current study, our goal was to analyze outcomes in newly diagnosed

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Morodomi, Yosuke, Roberto Aiolfi, Eric Won, et al. "Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice." Blood 134, Supplement_1 (2019): 1068. http://dx.doi.org/10.1182/blood-2019-127446.

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Introduction: It has been shown that megakaryocytes (MKs) can develop from a subset of MK-biased hematopoietic stem cells (HSCs). We also demonstrated that an active form of tyrosyl tRNA synthetase (YRS) has ex-translational activities that stimulate rapid platelet production in thrombocytopenic mice. Remarkably, YRS stimulates the development of MKs expressing the stem cell marker, Sca-1, and the monocyte/macrophage marker, F4/80. Thus, we hypothesized that YRS treatment mimics stress-induced megakaryopoiesis and Sca-1 may be a marker for MKs/platelets derived from MK-biased HSCs under inflam

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Bourreau, Jean-Pierre, Hamid S. Banijamali, and Cyril E. Challice. "Modification of excitation–contraction coupling in cat ventricular myocardium following endocardial damage." Canadian Journal of Physiology and Pharmacology 71, no. 3-4 (1993): 254–62. http://dx.doi.org/10.1139/y93-040.

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Damage to endocardial endothelium (denudation of the superficial tissue) by brief exposure to a 100-μL bolus of detergent (Triton X-100, 1% by volume stock) decreased the twitch force of papillary muscle (and trabeculae) by ~ 30% to a new but steady level without changes in resting tension. The decline in twitch force was evident immediately after the addition of Triton. Modification of the action potential measured from the contracting tissue appeared only later, when the change in contraction was already well established (i.e., after ~ 2 min). Action potential shortened in duration at 50% re

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Brown, Patrick A., Lingyun Ji, Xinxin Xu, et al. "A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in High and Intermediate Risk (HR/IR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs) Demonstrates Superior Efficacy and Tolerability of Blinatumomab: A Report from Children's Oncology Group Study AALL1331." Blood 134, Supplement_2 (2019): LBA—1—LBA—1. http://dx.doi.org/10.1182/blood-2019-132435.

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First relapse of B-ALL in children and AYAs is a vexing clinical problem with high rates of subsequent relapse and death using conventional treatment approaches. This is especially true in patients with early relapse [high risk (HR), defined as marrow relapse <36 months from diagnosis or isolated extramedullary relapse <18 months from diagnosis] and those with late relapse and minimal residual disease (MRD) of ≥0.1% at the end of re-induction chemotherapy [intermediate risk (IR)]. Allogeneic hematopoietic stem cell transplant (HSCT) is considered the treatment of choice for this populati

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Cui, Lu, Cristabelle De Souza, Tristan Lerbs, et al. "Selective Targeting of Immune Modulatory Proteins to Mitigate Fibrosis and Inflammation in Sclerodermatous Graft-Vs-Host Disease." Blood 138, Supplement 1 (2021): 644. http://dx.doi.org/10.1182/blood-2021-151223.

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Abstract Chronic graft-vs-host disease (cGVHD) is a major obstacle to the success of allogeneic hematopoietic stem cell transplantation (HCT) in patients. This debilitating condition is characterized by chronic inflammation, cell-mediated and humoral immunity, and ultimately tissue fibrosis. There is currently little or no understanding of the molecular pathogenesis of chronic cGVHD resulting in poor effective treatment strategies. Sclerodermatous GVHD (sclGVHD) is one of the more severe forms of cGVHD associated with poor prognosis and low sensitivity to immune suppressive therapy. Methods: T

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Lachowiez, Curtis, Courtney D. DiNardo, Kiyomi Morita, et al. "Longitudinal Next Generation Sequencing Reveals the Clonal Hierarchy of IDH Mutated Clones and Impact on Survival in NPM1 Mutated AML." Blood 138, Supplement 1 (2021): 607. http://dx.doi.org/10.1182/blood-2021-148971.

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Abstract Background: NPM1 mutations (NPM1 +) occur in ~30% of acute myeloid leukemia (AML), often with co-occurring mutations including isocitrate dehydrogenase mutations (IDH +). Previous studies suggest early acquisition and expansion of IDH1/2 mutations (IDH1 +/IDH2 +) prior to NPM1 + development increase relapse risk. Yet the clonal hierarchy of NPM1 +/IDH + AML, dynamics of IDH + during therapy, and predictive value of IDH1 +/2 + in NPM1 + AML in response to standard intensive (IC) or venetoclax-based (VEN) treatment is less studied. Methods: We identified 71 patients with newly diagnosed

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Hines, Patrick C., Xiufeng Gao, Andrew Herppich, et al. "Ex Vivo Evaluation of Red Blood Cell Adhesion and Whole Blood Thrombosis in Pyruvate Kinase Deficiency." Blood 138, Supplement 1 (2021): 923. http://dx.doi.org/10.1182/blood-2021-149744.

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Abstract Introduction Pyruvate Kinase Deficiency (PKD) is an inherited glycolytic enzymopathy that is characterized by a life-long chronic hemolytic anemia with severe comorbidities. Hypercoagulability due to increased platelet activity caused by nitric oxide sequestration by cell free hemoglobin has been well-described not just in PKD, but in other hemolytic anemias as well, such as e.g., sickle cell disease (SCD). Hypercoagulability is often accompanied by a cascade of pathophysiological events leading to cell oxidative damage, endothelial activation, and changes in both cell stability and a

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Zhang, Bo, Prajish Iyer, Meiling Jin, et al. "Expression of Sf3b1-K700E accelerates the Development of Chronic Lymphocytic Leukemia in a Del(13q) Murine Model." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-139096.

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RNA splicing factor SF3B1 is one of the most recurrently mutated genes in chronic lymphocytic leukemia (CLL), but expression of this mutation alone in murine B cells does not result in CLL. This gene mutation is often subclonal and associated with poor survival. How this mutation impacts CLL progression remains elusive. Since SF3B1 mutation frequently co-occurs with chromosome 13q deletion (del(13q)), and mice with deletion of the Minimal Deleted Region (MDR) of del(13q) develop indolent CLL, we therefore asked whether co-expression of Sf3b1 mutation can accelerate the onset of CLL in this mur

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Koller, Paul, Rima M. Saliba, Celina Ledesma, et al. "Allogeneic Hematopoietic Cell Transplantation May Improve Long-Term Outcomes in Patients with Ph-like Acute Lymphoblastic Leukemia with CRLF2 Overexpression." Blood 134, Supplement_1 (2019): 4598. http://dx.doi.org/10.1182/blood-2019-130645.

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Introduction: Philadelphia (Ph) like acute lymphoblastic leukemia (ALL) is a high risk subtype of ALL, with the majority of patients overexpressing CRLF2; CRLF2 overexpression is associated with particularly poor outcomes (Jain, Blood, 2017). To date, the efficacy of hematopoietic cell transplantation (HCT) in these patients is unknown. Methods: In this retrospective study, we evaluated patients with CRLF2 overexpressed ALL who received or did not receive HCT. CRLF2 status was identified via FISH or multi-parameter flow cytometry. We identified 55 patients treated at our institution from 1992-

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Loh, Mignon L., Richard C. Harvey, Charles G. Mullighan, et al. "A BCR-ABL1-Like Gene Expression Profile Confers a Poor Prognosis In Patients with High-Risk Acute Lymphoblastic Leukemia (HR-ALL): A Report From Children's Oncology Group (COG) AALL0232." Blood 118, no. 21 (2011): 743. http://dx.doi.org/10.1182/blood.v118.21.743.743.

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Abstract Abstract 743 We have previously identified a subset of National Cancer Institute (NCI)-HR B-cell precursor (BCP) ALL patients with a gene expression profile similar to that of BCR-ABL1 ALL (BCR-ABL1-like ALL (Mullighan, N Engl J Med 2009; den Boer, Lancet Oncology 2009; Harvey, Blood, 2010, and unpublished data) and poor outcome on the COG P9906 trial, which was limited to a selected subset of HR BCP ALL patients. These cases are BCR-ABL1-negative but commonly have deletion or mutation of IKZF1. Up to half of these cases harbor rearrangements, deletions and/or mutations activating cyt

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Tian, Linjie, Ana Paucarmayta, Rustin Lovewell, et al. "A Novel Lair-1 Antibody Selectively Targets Acute Myeloid Leukemia (AML) Stem Cells." Blood 138, Supplement 1 (2021): 3413. http://dx.doi.org/10.1182/blood-2021-147656.

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Abstract Extensive research has led to recent approval of novel therapies such as mylotarg, venetoclax, glasdegib and CC486, and small molecule inhibitors against actionable mutations such as ivosidenib (IDH1), enasidenib (IDH2), gliteritinib and midostaurin (FLT3) in AML. However, the mainstay of treatment in AML remains unchanged since the 1970s. There is a significant unmet need for AML patients that fail to respond to or relapse after standard-of-care (SOC) treatments including allogeneic stem cell transplantation and targeting actionable mutations. In addition, a large fraction of SOC pat

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Gisbert-Orozco, Jose F., Gerard Moras, Víctor Illera-Domínguez, Víctor Toro-Román, Carla Pérez-Chirinos Buxadé, and Bruno Fernández-Valdés. "Effects of Adding Mechanical Vibration and a Stick on Acceleration and Movement Variability during a Slide-Board Skating Exercise: Differences between the Dominant and Non-Dominant Legs." Applied Sciences 14, no. 4 (2024): 1481. http://dx.doi.org/10.3390/app14041481.

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The aim of the present study was to analyse differences in acceleration and movement variability caused by adding whole-body vibration (WBV) and an implement (stick) while performing a slide-board (SB) skating exercise. A total of 10 professional ice-hockey players (age 20.4 ± 2.07 years) participated in the study. Participants performed 30 s of lateral sliding on a slide vibration board (SVB). Four conditions were analysed: no vibration and no stick (NVNS), no vibration with a stick (NVS), vibration without a stick (VNS) and vibration with a stick (VS). Peak acceleration, mean acceleration an

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