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Journal articles on the topic 'Strain-promoted alkyne-azide cycloaddition'

Author: Grafiati

Published: 5 June 2025

Last updated: 24 June 2025

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1

Cormier, Morgan, Eric Fouquet, and Philippe Hermange. "Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions." Organic Chemistry Frontiers 6, no. 8 (2019): 1114–17. http://dx.doi.org/10.1039/c9qo00086k.

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A cycloheptyne dicobalt-carbonyl complex with a terminal alkyne was synthesized by a short procedure, and was able to react selectively in Strain Promoted Alkyne Azide Cycloaddition (SPAAC) or Copper Catalysed Alkyne Azide Cycloaddition (CuAAC) depending on the conditions.

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2

Lauer, Milena Helmer, Charlotte Vranken, Jochem Deen, et al. "Methyltransferase-directed covalent coupling of fluorophores to DNA." Chemical Science 8, no. 5 (2017): 3804–11. http://dx.doi.org/10.1039/c6sc04229e.

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3

Cai, Xuekang, Dan Wang, Yasi Gao, Long Yi, Xing Yang, and Zhen Xi. "Tetra-fluorinated aromatic azide for highly efficient bioconjugation in living cells." RSC Advances 9, no. 1 (2019): 23–26. http://dx.doi.org/10.1039/c8ra09303b.

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4

Liu, Xifeng, Ping Gong, Pengfei Song, et al. "Fast functionalization of ultrasound microbubbles using strain promoted click chemistry." Biomaterials Science 6, no. 3 (2018): 623–32. http://dx.doi.org/10.1039/c8bm00004b.

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5

Amgarten, Beatrice, Rakesh Rajan, Nuria Martínez-Sáez, et al. "Collagen labelling with an azide-proline chemical reporter in live cells." Chemical Communications 51, no. 25 (2015): 5250–52. http://dx.doi.org/10.1039/c4cc07974d.

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Biosynthetic incorporation of an azide-proline chemical reporter into collagen allows selective imaging in live foetal ovine osteoblasts using a strain-promoted [3+2] azide–alkyne cycloaddition reaction.

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6

Moon, Jeongbin, In-Seong Jo, Jeong Hoon Yoon, et al. "DNA functionalization of colloidal particles via physisorption of azide-functionalized diblock copolymers." Soft Matter 15, no. 35 (2019): 6930–33. http://dx.doi.org/10.1039/c9sm01243e.

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DNA-coated colloids are prepared simply by physical adsorption of azide-functionalized amphiphilic diblock copolymers onto hydrophobic inorganic particles, followed by strain-promoted azide–alkyne cycloaddition (SPAAC) reaction.

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7

Engel, Annikka, Eike Dornsiepen, and Stefanie Dehnen. "Click reactions and intramolecular condensation reactions on azido-adamantyl-functionalized tin sulfide clusters." Inorganic Chemistry Frontiers 6, no. 8 (2019): 1973–76. http://dx.doi.org/10.1039/c9qi00424f.

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8

Tian, He, Thomas P. Sakmar, and Thomas Huber. "A simple method for enhancing the bioorthogonality of cyclooctyne reagent." Chemical Communications 52, no. 31 (2016): 5451–54. http://dx.doi.org/10.1039/c6cc01321j.

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9

Liu, Xueping, Ying Wu, Minghui Zhang, and Ke Zhang. "Efficient polymer dimerization method based on self-accelerating click reaction." RSC Advances 10, no. 12 (2020): 6794–800. http://dx.doi.org/10.1039/c9ra09919k.

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A convenient and efficient method was developed to prepare topological polymers with a symmetric molecular structure by dimerizing azide terminated polymers based on the self-accelerating double strain-promoted azide–alkyne cycloaddition reaction.

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10

Weterings, Jimmy, Cristianne J. F. Rijcken, Harald Veldhuis, et al. "TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions." Chemical Science 11, no. 33 (2020): 9011–16. http://dx.doi.org/10.1039/d0sc03477k.

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11

Holstein, Josephin Marie, Daniela Schulz, and Andrea Rentmeister. "Bioorthogonal site-specific labeling of the 5′-cap structure in eukaryotic mRNAs." Chem. Commun. 50, no. 34 (2014): 4478–81. http://dx.doi.org/10.1039/c4cc01549e.

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12

Li, Huimin, Youcheng Yin, Anming Wang, et al. "Stable immobilization of aldehyde ketone reductase mutants containing nonstandard amino acids on an epoxy resin via strain-promoted alkyne–azide cycloaddition." RSC Advances 10, no. 5 (2020): 2624–33. http://dx.doi.org/10.1039/c9ra09067c.

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13

Liu, Xifeng, Ping Gong, Pengfei Song, et al. "Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery." Polymer Chemistry 10, no. 6 (2019): 705–17. http://dx.doi.org/10.1039/c8py01721b.

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14

Subramanian, Nithya, Jagadeesh Babu Sreemanthula, Baghavathi Balaji, Jagat R. Kanwar, Jyotirmay Biswas, and Subramanian Krishnakumar. "A strain-promoted alkyne–azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer–fluorescent conjugate for imaging of cancer cells." Chem. Commun. 50, no. 80 (2014): 11810–13. http://dx.doi.org/10.1039/c4cc02996h.

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15

van Hest, Jan C. M., and Floris L. van Delft. "Protein Modification by Strain-Promoted Alkyne-Azide Cycloaddition." ChemBioChem 12, no. 9 (2011): 1309–12. http://dx.doi.org/10.1002/cbic.201100206.

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16

Sun, Peng, Qingquan Tang, Zhenpeng Wang, Yuming Zhao, and Ke Zhang. "Cyclic polymers based on UV-induced strain promoted azide–alkyne cycloaddition reaction." Polymer Chemistry 6, no. 22 (2015): 4096–101. http://dx.doi.org/10.1039/c5py00416k.

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A unique ring-closure method was developed for the preparation of cyclic polymers based on the combination of atom transfer radical polymerization and UV-induced strain promoted azide–alkyne cycloaddition reaction.

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17

Warther, David, Enes Dursun, Marion Recher, et al. "Plasma induced acceleration and selectivity in strain-promoted azide–alkyne cycloadditions." Organic & Biomolecular Chemistry 19, no. 23 (2021): 5063–67. http://dx.doi.org/10.1039/d1ob00529d.

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We report the unexpected acceleration of strain-promoted azide–alkyne cycloaddition in human plasma compared to classical solvent systems. Besides fast kinetics, human plasma also allows for discrimination between two azides in competition reaction.

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18

Strmiskova, Miroslava, Didier A. Bilodeau, Mariya Chigrinova, and John Paul Pezacki. "Phenanthridine-based nitrones as substrates for strain-promoted alkyne-nitrone cycloadditions." Canadian Journal of Chemistry 97, no. 1 (2019): 1–6. http://dx.doi.org/10.1139/cjc-2018-0253.

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Over the past decade, bioorthogonal chemistry that facilitates the efficient conjugation of biomolecules has expanded from the copper-catalyzed alkyne-azide cycloadditions to a multitude of diverse reactions, varying additives and reactional partners, and most often offering better alternatives with faster rates and lower toxicity of employed reactants. Among these, the copper-free strain-promoted cycloaddition reactions have been demonstrated to be more promising, offering a reaction without toxic metal catalysts and with faster inherent kinetic rate constants. The strain-promoted alkyne-nitrone cycloadditions are easily tunable from both the (strained) alkyne and nitrone perspective, both compounds giving the opportunity to modulate the rate of reaction by substituting various positions. Previously, acyclic nitrones have been evaluated in the strain-promoted alkyne-nitrone reactions; however, they were notably prone to hydrolysis. Some five-membered ring endocyclic nitrones developed concomitantly offered the advantage of relatively fast kinetics and better resistance to degradation in aqueous conditions and have been successfully used for labelling of biomolecules in living systems. Herein, we have prepared and studied nitrones inspired by the phenanthridine scaffold that efficiently undergo strain-promoted alkyne-nitrone reactions. Phenanthridine nitrones react fast with strained cyclooctynes with large bimolecular rate constants while maintaining bioorthogonality and resistance to hydrolysis.

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19

Lima, Carolina G. S., Akbar Ali, Sander S. van Berkel, Bernhard Westermann, and Márcio W. Paixão. "Correction: Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide–alkyne cycloaddition." Chemical Communications 51, no. 60 (2015): 12139. http://dx.doi.org/10.1039/c5cc90314a.

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Correction for 'Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide–alkyne cycloaddition' by Carolina G. S. Lima et al., Chem. Commun., 2015, 51, 10784–10796.

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20

Lis, Christian, and Thorsten Berg. "Synthesis of TRIPCO: A New Cyclooctyne for iSPAAC." Synlett 30, no. 08 (2019): 939–42. http://dx.doi.org/10.1055/s-0037-1611481.

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Strain-promoted azide–alkyne cycloadditions (SPAAC) are widely used for labeling azide-functionalized biomolecules in living cells but create mixtures of isomeric triazoles. We recently expanded the scope of SPAAC to the isomer-free generation of large functional molecules in living cells by designing the symmetrical pyrrolocyclooctynes PYRROC and SYPCO, which do not form isomers in SPAAC. Here, we present the synthesis and kinetic characterization of the cyclooctyne TRIPCO as a new reagent for isomer-free SPAAC (iSPAAC). TRIPCO was found to react faster than PYRROC and SYPCO in the [3+2] cycloaddition with benzyl azide.

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21

Anderton, Grant I., Alyssa S. Bangerter, Tyson C. Davis, et al. "Accelerating Strain-Promoted Azide–Alkyne Cycloaddition Using Micellar Catalysis." Bioconjugate Chemistry 26, no. 8 (2015): 1687–91. http://dx.doi.org/10.1021/acs.bioconjchem.5b00274.

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22

McNelles, Stuart A., Julia L. Pantaleo, Eric Meichsner, and Alex Adronov. "Strain-Promoted Azide-Alkyne Cycloaddition-Mediated Step-Growth Polymerization." Macromolecules 52, no. 19 (2019): 7183–87. http://dx.doi.org/10.1021/acs.macromol.9b01609.

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23

Jacobs, Monique J., Guenter Schneider, and Kerstin G. Blank. "Mechanical Reversibility of Strain-Promoted Azide-Alkyne Cycloaddition Reactions." Angewandte Chemie International Edition 55, no. 8 (2016): 2899–902. http://dx.doi.org/10.1002/anie.201510299.

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24

Trindade, Alexandre F., Raquel F. M. Frade, Ermelinda M. S. Maçôas, et al. "“Click and go”: simple and fast folic acid conjugation." Org. Biomol. Chem. 12, no. 20 (2014): 3181–90. http://dx.doi.org/10.1039/c4ob00150h.

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A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne–azide cycloaddition, without the need for expensive chromatographic purifcation.

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25

Leier, Samantha, and Frank Wuest. "Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry." Pharmaceuticals 17, no. 10 (2024): 1270. http://dx.doi.org/10.3390/ph17101270.

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Background: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach. Methods: Traditionally, click-based radiolabeling techniques have focused on classical click chemistry, such as copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC), strain-promoted azide-alkyne [3+2] cycloaddition (SPAAC), traceless Staudinger ligation, and inverse electron demand Diels–Alder (IEDDA). Results: However, newly emerging click-based radiolabeling techniques, including tyrosine-click, sulfo-click, sulfur(VI) fluoride exchange (SuFEx), thiol-ene click, azo coupling, hydrazone formations, oxime formations, and RIKEN click offer valuable alternatives to classical click chemistry. Conclusions: This review will discuss the applications of these techniques in peptide radiochemistry.

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26

Whitehead, Stuart A., Christopher D. McNitt, Samuel I. Mattern-Schain, et al. "Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne–Azide Cycloaddition." Bioconjugate Chemistry 28, no. 4 (2017): 923–32. http://dx.doi.org/10.1021/acs.bioconjchem.6b00578.

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27

van Hest, Jan C. M., and Floris L. van Delft. "ChemInform Abstract: Protein Modification by Strain-Promoted Alkyne-Azide Cycloaddition." ChemInform 42, no. 44 (2011): no. http://dx.doi.org/10.1002/chin.201144229.

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28

Cruchter, Thomas, Klaus Harms, and Eric Meggers. "Strain‐Promoted Azide–Alkyne Cycloaddition with Ruthenium(II)–Azido Complexes." Chemistry – A European Journal 19, no. 49 (2013): 16682–89. http://dx.doi.org/10.1002/chem.201302502.

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29

Gobbo, Pierangelo, Zack Mossman, Ali Nazemi, et al. "Versatile strained alkyne modified water-soluble AuNPs for interfacial strain promoted azide–alkyne cycloaddition (I-SPAAC)." J. Mater. Chem. B 2, no. 13 (2014): 1764–69. http://dx.doi.org/10.1039/c3tb21799j.

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Versatile water-soluble AuNPs that incorporate an interfacial strained alkyne were synthesized and their reactivity towards the I-SPAAC reaction was demonstrated by using azide-decorated polymersomes as bioorthogonal reaction partners.

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30

Smits, Ferdinanda C. M., Wilke W. A. Castelijns, and Jan C. M. van Hest. "Crosslinked ELP-based nanoparticles, using the strain promoted azide–alkyne cycloaddition." European Polymer Journal 62 (January 2015): 386–93. http://dx.doi.org/10.1016/j.eurpolymj.2014.07.004.

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31

Li, Shanshan, He Zhu, Jiajia Wang, et al. "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) inO-GlcNAc proteomics." ELECTROPHORESIS 37, no. 11 (2016): 1431–36. http://dx.doi.org/10.1002/elps.201500491.

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32

Park, Jong-Ryul, Eleonore C. L. Bolle, Amanda Dos Santos Cavalcanti, et al. "Injectable biocompatible poly(2-oxazoline) hydrogels by strain promoted alkyne–azide cycloaddition." Biointerphases 16, no. 1 (2021): 011001. http://dx.doi.org/10.1116/6.0000630.

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33

Zheng, Jukuan, Kaiyi Liu, Darrell H. Reneker, and Matthew L. Becker. "Post-Assembly Derivatization of Electrospun Nanofibers via Strain-Promoted Azide Alkyne Cycloaddition." Journal of the American Chemical Society 134, no. 41 (2012): 17274–77. http://dx.doi.org/10.1021/ja307647x.

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34

Fong, Darryl, Jason Yeung, Stuart A. McNelles, and Alex Adronov. "Decoration of Polyfluorene-Wrapped Carbon Nanotubes via Strain-Promoted Azide–Alkyne Cycloaddition." Macromolecules 51, no. 3 (2018): 755–62. http://dx.doi.org/10.1021/acs.macromol.8b00049.

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35

Ko, Wooseok, Sunhwa Jin, Junmo Lee, et al. "Efficient and Site-Specific Antibody Labeling by Strain-promoted Azide-Alkyne Cycloaddition." Bulletin of the Korean Chemical Society 36, no. 9 (2015): 2352–54. http://dx.doi.org/10.1002/bkcs.10423.

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36

Takeda, Naoki, Shuichi Akasaka, Susumu Kawauchi, and Tsuyoshi Michinobu. "Metal-free double azide addition to strained alkynes of an octadehydrodibenzo[12]annulene derivative with electron-withdrawing substituents." Beilstein Journal of Organic Chemistry 20 (September 4, 2024): 2234–41. http://dx.doi.org/10.3762/bjoc.20.191.

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Strain-promoted azide–alkyne cycloaddition (SpAAC) is a powerful tool in the field of bioconjugation and materials research. We previously reported a regioselective double addition of organic azides to octadehydrodibenzo[12]annulene derivatives with electron-rich alkyloxy substituents. In order to increase the reaction rate, electron-withdrawing substituents were introduced into octadehydrodibenzo[12]annulene. In this report, the synthesis of new octadehydrodibenzo[12]annulene derivatives, regioselective double addition of organic azides, and an application to crosslinking polymers are described.

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37

He, Yinming, Li Liu, and Liang Cheng. "A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives." Molecules 28, no. 9 (2023): 3715. http://dx.doi.org/10.3390/molecules28093715.

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Cyclooctyne molecules have found wide applications in the strain-promoted azide–alkyne cycloaddition (SPAAC) reactions, which avoid the biotoxicity caused by the use of Cu(I) catalysts. Among the various cyclooctyne systems, dibenzocyclooctyne (DBCO) series have displayed the highest reaction activity. However, the synthesis processes of such structures are time-consuming, which to some extent limit their large-scale development and application. This review has summarized current synthesis routes of two DBCO molecules, aza-dibenzocyclooctyne (DIBAC) and biarylazacyclooctynone (BARAC).

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38

van Geel, Remon, Ger J. M. Pruijn, Floris L. van Delft, and Wilbert C. Boelens. "Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition." Bioconjugate Chemistry 23, no. 3 (2012): 392–98. http://dx.doi.org/10.1021/bc200365k.

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39

Schoffelen, Sanne, Jules Beekwilder, Marjoke F. Debets, Dirk Bosch, and Jan C. M. van Hest. "Construction of a Multifunctional Enzyme Complex via the Strain-Promoted Azide–Alkyne Cycloaddition." Bioconjugate Chemistry 24, no. 6 (2013): 987–96. http://dx.doi.org/10.1021/bc400021j.

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40

Hu, Jinghui, Peng Sun, Xiubo Jiang, Wen Zhu, and Ke Zhang. "Tadpole-shaped polymers based on UV-induced strain promoted azide-alkyne cycloaddition reaction." Science China Chemistry 59, no. 10 (2016): 1277–82. http://dx.doi.org/10.1007/s11426-016-0126-5.

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41

Meichsner, Eric, Darryl Fong, Dialia E. M. Ritaine, and Alex Adronov. "Strain‐promoted azide‐alkyne cycloaddition polymerization as a route toward tailored functional polymers." Journal of Polymer Science 59, no. 1 (2020): 29–33. http://dx.doi.org/10.1002/pol.20200573.

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42

Beatty, Kimberly E., John D. Fisk, Brian P. Smart, et al. "Live-Cell Imaging of Cellular Proteins by a Strain-Promoted Azide-Alkyne Cycloaddition." ChemBioChem 11, no. 15 (2010): 2092–95. http://dx.doi.org/10.1002/cbic.201000419.

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43

Yang, Hao, Poonam Srivastava, Chen Zhang, and Jared C. Lewis. "A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide-Alkyne Cycloaddition." ChemBioChem 15, no. 2 (2013): 223–27. http://dx.doi.org/10.1002/cbic.201300661.

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44

Timmers, Matt, Andi Kipper, Raphael Frey, et al. "Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide–Alkyne Cycloaddition Reactions." Pharmaceuticals 16, no. 8 (2023): 1155. http://dx.doi.org/10.3390/ph16081155.

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The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide–alkyne cycloaddition (SPAAC), metal-free click chemistry. This research explores the properties of TMTHSI-based compounds via three aspects: (1) large-scale production, (2) unique stability in acidic conditions and its subsequent use in peptide synthesis, and (3) the functionalization of antibodies. Here, it is shown that (1) scale-up is achieved on a scale of up to 100 g. (2) TMTHSI is remarkably stable against TFA allowing for the site-specific functionalization of peptides on resin. Finally, (3) the functionalization of an antibody with a model payload is very efficient, with antibody conjugation demonstrating more beneficial features such as a high yield and limited hydrophobicity as compared to other alkyne reagent conjugates. These results illustrate the high potential of TMTHSI for diverse bioconjugation applications, with production already being GMP-compatible and a highly efficient conversion resulting in attractive costs of goods.

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45

Fong, Darryl, Grace M. Andrews, Stuart A. McNelles, and Alex Adronov. "Decoration of polyfluorene-wrapped carbon nanotube thin films via strain-promoted azide–alkyne cycloaddition." Polymer Chemistry 9, no. 35 (2018): 4460–67. http://dx.doi.org/10.1039/c8py01003j.

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Latently reactive polymer–SWNT complexes were prepared by coating SWNTs with polyfluorene containing azide moieties in the side chain, allowing spatially resolved decoration of nanotube thin films with various functionalities.

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46

MacKenzie, Douglas A., and John Paul Pezacki. "Kinetics studies of rapid strain-promoted [3+2] cycloadditions of nitrones with bicyclo[6.1.0]nonyne." Canadian Journal of Chemistry 92, no. 4 (2014): 337–40. http://dx.doi.org/10.1139/cjc-2013-0577.

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Strain-promoted alkyne−nitrone cycloaddition (SPANC) reactions represent a bioorthogonal labeling strategy that is both very rapid and at the same time efficient and selective. Nitrones provide increased reaction rates as well as greater susceptibility toward stereoelectronic modification when compared with organic azides. We find that strain-promoted cycloadditions of cyclic nitrones with bicyclo[6.1.0]nonyne react with second-order rate constants as large as 1.49 L mol−1 s−1 at 25 °C. These reactions display rate constants that are up to 37-fold greater than those of the analogous reactions of benzyl azide with bicyclo[6.1.0]nonyne. We observed that reactions of nitrones with bicyclo[6.1.0]nonyne showed a stronger dependence on substituent effect for the reaction, as evidenced by a larger Hammett ρ value, than that for biaryl-aza-cyclooctanone. We demonstrate the ability to stereoelectronically tune the reactivity of nitrones towards different cyclooctynes in SPANC reactions. This ability to introduce selectivity into different SPANC reactions through substituent provides the opportunity to perform multiple SPANC reactions in one reaction vessel and opens up potential applications in multiplex labeling.

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47

Zhang, Hailei, Huan Zhong, Xufeng Wang, et al. "Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping." Proceedings of the National Academy of Sciences 118, no. 14 (2021): e2026183118. http://dx.doi.org/10.1073/pnas.2026183118.

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Recent findings regarding nicotinamide adenine dinucleotide (NAD+)-capped RNAs (NAD-RNAs) indicate that prokaryotes and eukaryotes employ noncanonical RNA capping to regulate gene expression. Two methods for transcriptome-wide analysis of NAD-RNAs, NAD captureSeq and NAD tagSeq, are based on copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry to label NAD-RNAs. However, copper ions can fragment/degrade RNA, interfering with the analyses. Here we report development of NAD tagSeq II, which uses copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling NAD-RNAs, followed by identification of tagged RNA by single-molecule direct RNA sequencing. We used this method to compare NAD-RNA and total transcript profiles of Escherichia coli cells in the exponential and stationary phases. We identified hundreds of NAD-RNA species in E. coli and revealed genome-wide alterations of NAD-RNA profiles in the different growth phases. Although no or few NAD-RNAs were detected from some of the most highly expressed genes, the transcripts of some genes were found to be primarily NAD-RNAs. Our study suggests that NAD-RNAs play roles in linking nutrient cues with gene regulation in E. coli.

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48

Pramudya, Irawan, Cheoljae Kim, and Hoyong Chung. "Synthesis and adhesion control of glucose-based bioadhesive via strain-promoted azide–alkyne cycloaddition." Polymer Chemistry 9, no. 26 (2018): 3638–50. http://dx.doi.org/10.1039/c8py00339d.

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49

Kechkeche, Djamila, Sirine El Mousli, Claire Poujouly, et al. "Strain promoted azide alkyne cycloaddition, an efficient surface functionalization strategy for microRNA magnetic separation." Next Materials 6 (January 2025): 100409. http://dx.doi.org/10.1016/j.nxmate.2024.100409.

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50

Wang, Shuangshuang, Xiaoke Yang, Wen Zhu, et al. "Strain-promoted azide-alkyne cycloaddition “click” as a conjugation tool for building topological polymers." Polymer 55, no. 19 (2014): 4812–19. http://dx.doi.org/10.1016/j.polymer.2014.08.003.

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