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Dissertations / Theses on the topic 'Strategic Targeting'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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1

Chiang, Jong-Tsong. "Strategic positioning of national technology-targeting programs." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/13086.

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2

Choong, Wi Yan Kelly. "Cryptic marketing : strategic targeting of subculture markets." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/79904/4/Wi_Choong_Thesis.pdf.

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This research aims to understand what factors influence consumers' behaviour to subculture marketing and how companies can strategically overcome potential brand alienation. Findings validate cryptic marketing as a strategy for organizations to communicate effectively with their chosen market through the use of cryptic cues, symbols and messages while circumventing negative responses from non-target audiences. The thesis contributes to extending current understanding of marketing communication through the use of covert strategies, employing covert tactics on the non-target, wider market instea
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Hultman, Lisa. "Targeting the Unarmed : Strategic Rebel Violence in Civil War." Doctoral thesis, Uppsala : Department of Peace and Conflict Research, Uppsala University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8852.

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4

Bras, Laurel Ann. "A rapid response software modification process for SLBM targeting software." Master's thesis, Virginia Tech, 1995. http://hdl.handle.net/10919/45231.

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The need for a faster, streamlined process for the modification of SLBM targeting software without sacrificing product reliability was identified. Both error correction and changes in software requirements were considered in the design of this process. Criteria for the design and use of the rapid response software development process were based on the magnitude, time sensitivity, and importance to strategic targeting of the modifications requested. Other concepts addressed included configuration management, customer service, teamwork, empowerment, and process improvement. The process contain
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5

Hrbatová, Jana. "Návrh marketingové strategie pro firmu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2017. http://www.nusl.cz/ntk/nusl-319209.

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The diploma thesis deals with analysis of the current situation of the company operating in wine industry to suggest a proposal of marketing strategy focusing on wine production, from the point of view of modification conventional production to biowine production. The work includes thorough strategic analysis of external and internal environment which is summarize in SWOT analysis and based on outputs the proposals are suggested in marketing mix 4 P.
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Loza, Aguirre Edison Fernando. "Enabling adoption decision-making for strategic scanning." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAG003/document.

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En réponse à une demande institutionnelle, réorientée par les conclusions d'une étude exploratoire et confirmée par une revue de littérature, cette thèse cherche à répondre à la question de recherche suivante : comment rendre possible la prise de décision d'adopter une veille stratégique (VS) ? Ce travail suit un modèle multipapier dans lequel chaque étude contribue à répondre à la question de recherche principale. Notre première étude (chapitre 2) nous a permis de comprendre que les pressions institutionnelles ont une influence sur la décision mentale d'adopter ou pas une VS. Les chapitres 3
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Beneš, David. "Návrh marketingové strategie." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377552.

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This diploma thesis is focused on the design of a marketing strategy within a selected company. In the theoretical part, an examination of currently available professional literature has been made. This literature, which describes individual marketing systems, is used as subsequent source material for the empirical component of this thesis. The analytical section focuses on a description of FITCOACH s.r.o, its position in its market and an overview of competitors in this sector. The main goal of the thesis is the proposal of a marketing strategy for FITCOACT, s.r.o. In conclusion, this thesis
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Balsiger, Philip. "Campaigning for Clean Clothes : the origins and strategic interactions of a social movement campaign targeting retailers in Switzerland and France." Paris, Institut d'études politiques, 2011. http://www.theses.fr/2011IEPP0006.

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Cette thèse compare les origines, dynamiques, et effets des campagnes visant les distributeurs de vêtements en Suisse et en France dans les années 1990 et 2000. Ces campagnes demandent l’adoption de codes de conduites concernant le respect de critères sociaux dans les conditions de production du textile. La recherche étudie ainsi l’inscription de l’enjeu des conditions de production dans le marché du vêtement et la structuration différente, selon les dynamiques d’interaction des campagnes, de ce marché. Pour ce faire, une approche multi-institutionnelle et interactionniste des campagnes de mou
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Gnojek, Michaela, and Emelie Ljungblad. "Kommunicerad Talang : Kartläggning och utvärdering av Talang 2010´s externa kommunikation." Thesis, Linnéuniversitetet, Institutionen för samhällsvetenskaper, SV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-8915.

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This thesis will explore how swedish Talang 2010 used their strategic communication in Kalmar and Stockholm and how the effect of this work was shown in the two cities. With a focus on how the sender was working with the external communication in the two cities, the heart of the research was studying Talang 2010’s communication strategy in these two contexts. The research was made with surveys during two audition days in Kalmar and two days in Stockholm. The competitors, the audience and the general public were answering different surveys but with the same base to study the effect. For studyin
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Ahdidan, Mabrokka Abdallah. "The effect of information technology on competitive advantage in Libyan oil companies : a conceptual model for targeting strategic information systems investment." Thesis, Abertay University, 2013. https://rke.abertay.ac.uk/en/studentTheses/61d7e408-f70d-4911-aacd-0c80340b9be8.

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This thesis focuses on the significant effect on business performance as a result of the dynamic connection between information technology (IT) strategy and business strategy. After an extensive review of the relevant literature, the important dimensions of the content and process domains of IT strategy and business strategy were identified and operationalised. Consequently, a conceptual model is developed to explain the structural relationship between IT strategy, business strategy and business performance. A Questionnaire survey was used as the main data collection tool within all the local
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11

M'Baye, Cheick Kader. "Theoretical and empirical essays on inflation targeting and central bank transparency." Thesis, Lyon 2, 2013. http://www.theses.fr/2013LYO22010.

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Cette thèse contribue au débat sur les politiques de ciblage d’inflation et de transparence des banques centrales en présentant notamment trois essais théoriques et empiriques sur le sujet. Dans le premier essai, nous étudions théoriquement les conditions sous lesquelles il serait optimal pour une banque centrale d’adopter explicitement un régime de ciblage d’inflation. Nous proposons un nouveau cadre théorique qui combine les deux principales raisons avancées dans la littérature pour expliquer les effets réels à court terme de la politique monétaire et qui sont d’une part, la présence d’infor
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12

Jansson, Nicklas, and Gustav Allard. "Kommunikatörens strategiska roll i SHL : En kvalitativ studie om Svenska Hockeyligan och strategisk kommunikation med inriktning på sociala medier." Thesis, Högskolan i Gävle, Media- och kommunikationsvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-24619.

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Denna studie undersöker hur kommunikatörer arbetar med strategisk kommunikation i Sveriges högsta ishockeyliga SHL. Uppsatsen är inriktad på sociala medier och hur kommunikatörerna arbetar med de möjligheter som detta medfört. Uppsatsen undersöker även vilken roll kommunikatören får i organisationen Vårt syfte är således att skapa en förståelse för kommunikatörens roll i organisationen och hur de genomför sitt arbete ur en strategisk synvinkel.           För att komma fram till ett resultat har vi använt oss av kvalitativa intervjuer med kommunikatörer anställda av de ishockeyklubbar som tillh
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Economou, Emmanuel. "How institutional pressures influence data-driven corporate communications." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/209153/1/Emmanuel_Economou_Thesis.pdf.

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This study explores the use of data to guide corporate communications, a practice of which empirical research is limited, and is the first to investigate how institutional pressures influence practitioners in their work. In-depth interviews were conducted with 15 participants from a wide range of organisations in Brisbane, Australia. Additionally, the study illustrates the current state of research on big data in corporate communication in a systematic literature review. The study’s findings indicate that institutional pressures influence data-driven corporate communications and are generally
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Carlsson, Ricky, and Alexander Vilhelmsson. "Nej tack till onödig reklam! : En studie om riktad marknadsföring via Big Data från ett konsumentperspektiv." Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176771.

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Title: No thanks to unnecessary advertising! -A study on targeted marketing via Big Data in a consumer perspective Authors: Ricky Carlsson and Alexander Vilhelmsson Supervisor: Anders Parment Key words: Targeted marketing, Big Data, Customer segmentation, Buying process, Integrity concern, Customer relationship management, Marketing communication, Strategic management, Big Data management, Online Behavioural Targeting Introduction: In a world that is globalizing and where digital development is advancing, companies have had to adapt. In recent times with the increasingly more digital world, te
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15

Trimby, Christopher Matthew. "STRATEGIES FOR TARGETING LENTIVIRAL VECTORS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/157.

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Lentiviral gene therapy has held great promise for treating a wide range of neurological disorders due to its ability to stably integrate into the genome of nondividing cells like neurons, in addition to dividing cells. The nervous system is a complex and highly heterogeneous system, and while a therapeutic intervention may have beneficial effects in one population of cells it may have severe side effects in another. For this reason, specific targeting of lentiviral vectors is crucial for their ultimate utility for research and clinical research use. Two different approaches for focusing the t
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16

Sapáková, Hana. "Marketingová strategie společnosti Expensa, a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359374.

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The theme of this thesis is the marketing strategy of Expensa company. Expensa joint-stock company provides a unique managing and controlling system for company cash expenditures. This system includes Expensa company payment cards.The aim of this thesis is to (based on current situation) raise potential clients awareness of Expensa company by proposing a partial improvement of marketing strategy. Proposal of new segment which will help Expensa to increase higher market share and competitive ability is the specific output. Theoretical section describes marketing strategies, elements of the mark
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17

Habartová, Tereza. "Marketingová strategie vinného sklepu." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-201719.

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Diploma thesis Marketing strategy of wine cellar will introduce strategic mareting and service marketing in theoretical part. Furthermore, in the theoretical part, I write about the segmentation, targeting and positioning. The practical part is devoted to the story of wine cellar, statistical data about wine and competition analysis. The most part of the practical part deals with questionnaire. The results of this investigation should be useful to the proper market segmentation, targeting and positioning further. The evaluation questionnaire also illustrate SWOT analysis and recommendations fo
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18

Michaud, David. "Marketingová strategie Renaultu: výzvy střednědobého plánu." Master's thesis, Vysoká škola ekonomická v Praze, 2006. http://www.nusl.cz/ntk/nusl-76.

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Diplomová práce ?Marketingová strategie Renaultu: výzvy střednědobého plánu? si klade za cíl analyzovat marketingovou strategii společnosti Renault. Práce nejdříve popisuje společnost Renault jako takovou. Zaměřuje se na historii společnosti, firemní strategii a aktuální střednědobé cíle. Následující část popisuje přístup firmy Renault k výzkumu trhu. Zde je popsán jak kontinuální, tak jednorázový výzkum. Poté práce detailně rozebírá segmentaci, targeting a positioning. Všechny tři strategické marketingové přístupy jsou analyzovány teoreticky i prakticky, tedy z pohledu firmy Renault.
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Sze, Jun Hui. "Targeting Thioredoxin Reductase in Multiple Myeloma." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392857.

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Multiple myeloma (MM) is a clonal plasma B-cell neoplasm characterised by the presence of uncontrolled proliferation of antibody-secreting plasma cells in the bone marrow. Despite therapeutic advancements, MM remains incurable due to its low median survival rate and nearly all patients will eventually relapse regardless of the frontline regimen they receive. Thus, alternative therapeutic strategies that target the pathogenic and resistance mechanisms of MM need to be developed to improve overall survival in MM patients. Cancer cells generally have higher metabolic demands due to their high pro
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20

Zhang, Liang. "Strategies for local drug delivery targeting the oesophagus." Thesis, Aston University, 2008. http://publications.aston.ac.uk/15410/.

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Localised, targeted drug delivery to the oesophagus offers the potential for more effective delivery and reduced drug dosages, coupled with increased patient compliance. This thesis considers bioadhesive liquids, orally retained tablets and films as well as chewable dosage forms as drug delivery systems to target the oesophagus. Miconazole nitrate was used as a model antifungal agent. Chitosan and xanthan gum hydrogels were evaluated as viscous polymer viables with the in vitro retention, drug release and minimum inhibitory concentration values of the formulations measured. Xanthan showed prol
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Maliapen, Mahendran. "Strategies for targeting disease genes and clinical treatments." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12877.

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Despite the enthusiasm about applying systems-level gene expression data in biomedicine, the progress in scientific discovery and clinical adoption of these technologies is still limited. The key bottleneck seems to be the lack of integration and the need for software technologies to analyze disease phenotypic and drug genotypic data at the point of prescription. The availability of appropriate visualization, analytical techniques to support clinical decision making that can reference published deleterious SNPs of pharmcogenes for the drugs prescribed is lacking. In this thesis, the integratio
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Castle, Lianne. "Targeting interstrand crosslink repair to improve chemotherapeutic strategies." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:8d8c763a-195e-4e1c-b1b4-12a7bc67a2c8.

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Many clinically effective chemotherapeutic agents exert their toxicity through formation of DNA interstrand cross-links (ICL). These prevent the replication and transcription of DNA and if unrepaired lead to cell death. Despite the success of ICL inducing agents in treating cancers, issues remain with a lack of sensitivity in some tumours, therapy-limiting toxicity and acquired resistance and tumour recurrence. The modulation of ICL repair could improve chemotherapy outcomes and the specific targeting of ICL repair in quiescent cells may selectively target cancer stem cells and ameliorate issu
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Simsek, Senem. "DEVELOPMENT OF TRAPPING STYLE CASSETTES FOR NEW GENE TARGETING STRATEGIES." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1193679015297-95667.

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Because of shared physiological, anatomical and metabolical features with humans, mice have served for a long time as mammalian disease models. In particular, these last ten years have been the golden age for this favoured model animal. Human and mouse genome projects show that there is 95% genome homology. Spurred by this fact, research attention has shifted from reading these sequences to deciphering the functions of these genes. The 1980s saw the remarkable achievement of homologous recombination in mammalian cell culture systems. Later in the 1990s, innovative gene trapping strategies were
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Spiegelberg, Diana. "Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies." Doctoral thesis, Uppsala universitet, Medicinsk strålningsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-247539.

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This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. Special focus has been on the cell surface molecule CD44 and its oncogenic variants, which were found to exhibit unique expression patterns in head and neck squamous cell carcinoma (HNSCC). The v
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Zephyr, Jacqueto. "Robust Drug Design Strategies and Discovery Targeting Viral Proteases." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1157.

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Viral proteases play crucial roles in the life cycle and maturation of many viruses by processing the viral polyprotein after translation and in some cases cleaving host proteins associated with the immune response. The essential role of viral proteases makes them attractive therapeutic targets. In this thesis, I provide an introductory summary of viral proteases, their structure, mechanism, and inhibition, while the breadth of this thesis focuses on the Hepatitis C virus (HCV) NS3/4A and Zika virus (ZIKV) NS2B/NS3 viral proteases. HCV NS3/4A protease inhibitors (PIs) have become a mainstay in
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Ryan, Philip. "An Investigation Into Novel Molecular Strategies Targeting Neurodegenerative Diseases." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/395102.

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Neurodegenerative diseases are characterised by the progressive loss of neuron function and structure. The most prevalent neurodegenerative diseases are hypothesized to be due to the misfolding and accumulation of specific proteins in the brain. Alzheimer’s disease (AD) is suspected to result from the aggregation of amyloid-β (Aβ) or tau proteins, Parkinson’s disease (PD) from the aggregation of α-synuclein (α-syn), and so on for numerous other diseases including Huntington’s disease, amyotrophic lateral sclerosis, and Creutzfeldt-Jakob disease. There are no curative therapies for any of these
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FREGONESE, FEDERICO. "Strategie di drug targeting and delivery applicate ai complessi di platino." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/81937.

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28

Foskolos, Andreas. "Strategies to Reduce Nitrogen Excretion from Ruminants: Targeting the Rumen." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/107885.

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Esta tesis doctoral se llevó a cabo en el marco del proyecto financiado por la Unión Europea Rednex. El objetivo principal de la tesis fue utilizar tecnologías innovadoras aplicadas al rumen para proponer soluciones que pueden reducir la excreción de N en el ganado bovino lechero. Se llevaron a cabo cuatro estudios para evaluar: la espectroscopia de infrarrojo cercano como herramienta para mejorar la precisión en la formulación de raciones en la granja; el uso de anticuerpos policlonales (APs) contra las principal bacterias proteolíticas y desaminadoras en el rumen; y, el uso de compuestos de
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Vakaloudis, Dmitri. "Application of Volatility Targeting Strategies within a Black-Scholes Framework." Master's thesis, Faculty of Commerce, 2019. http://hdl.handle.net/11427/31319.

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The traditional Black-Scholes (BS) model relies heavily on the assumption that underlying returns are normally distributed. In reality however there is a large amount of evidence to suggest that this assumption is weak and that actual return distributions are non-Gaussian. This dissertation looks at algorithmically generating a Volatility Targeting Strategy (VTS) which can be used as an underlying asset. The rationale here is that since the VTS has a constant prespecified level of volatility, its returns should be normally distributed, thus tending closer to an underlying that adheres to the a
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ZUFFO, MICHELA. "Strategies for the selective targeting of specific G-quadruplex structures." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1214897.

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Mounting evidence suggests that nucleic acids able to fold into G-quadruplex structures play pivotal roles in the regulation of various and relevant biological processes. However, ligands that are selective for specific G4 structures are currently lacking. This is due to the high structural similarity of G4s, making specific targeting extremely challenging. Despite this, there is an urgent need of such tools as a mean to better understand G4 biological activity and to investigate their potential as therapeutic targets. In order to bridge this gap, three strategies are proposed in this work, th
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MILANI, Roberta. "Emerging strategies for selective targeting in therapeutic approaches against gliomas." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2478803.

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Il glioblastoma multiforme (GBM) è tra i tumori cerebrali più aggressivi, generalmente compare in età adulta ed è caratterizzato da eterogeneità cellulare e diverse alterazioni genetiche (Louis DN, 2016). La terapia standard consiste in una combinazione di chirurgia, radioterapia e chemioterapia. Nonostante l’aggressività dei trattamenti, non esiste ancora una cura definitiva e il tasso medio di sopravvivenza è di soli 14,6 mesi (Wilson TA, 2014). Il farmaco di elezione nel trattamento del glioblastoma è la temozolomide (TMZ). La TMZ è un agente alchilante e viene utilizzato da solo o i
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Havlíková, Žaneta. "Marketingová strategie vybrané firmy." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-81321.

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This thesis is based on the basic informations of the company,the marketing situational analysis is broken down in the internal and external analysis using PEST analysis, analysis of product portfolio - the Boston Matrix, Porter's five forces model and SWOT analysis. There is a description of the current business developments and current status. This thesis describes the opportunities, skills and resources of the company. Further I have specified the basic mission and objectives, market segmentation,targeting and positioning. The conclusion contains the marketing strategies according to the pr
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MANGIAPANE, Laura Rosa. "TOWARDS COLORECTAL CANCER STEM CELLS TARGETING: INVESTIGATING GENETIC AND EPIGENETIC LANDSCAPE." Doctoral thesis, Università degli Studi di Palermo, 2022. https://hdl.handle.net/10447/554701.

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Pérez, Zsolt Daniel. "New therapeutic strategies targeting dendritic cell-mediated dissemination of enveloped viruses." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/669547.

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Les cèl·lules dendrítiques (DCs) són clau en la inducció de respostes immunitàries adaptatives gràcies a la seva capacitat de capturar, processar i presentar antígens derivats de patògens als limfòcits T. Tanmateix, aquestes cèl·lules podrien contribuir a la disseminació inicial del VIH-1 a través de la captura i transmissió viral a les cèl·lules T CD4+ diana, un procés conegut com a trans-infecció. Aquest mecanisme es basa en l’expressió del receptor Siglec-1 (CD169), que reconeix gangliòsids sialilats a la membrana viral. Els nivells de Siglec-1 augmenten en DCs estimulades amb interferó-alf
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Canatsey, Ryan Douglas. "Combination Therapeutic Strategies Targeting Growth and Metabolic Pathways in Prostate Cancer." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/613236.

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Despite recent advances, prognosis in metastatic prostate cancer remains poor. As with other cancers, tumor heterogeneity is an increasingly evident contributor in prostate tumorigenesis and developed resistance. Using in vitro and in vivo model systems, we examined novel diagnostic and therapeutic strategies in prostate cancer. In these studies, combination treatment with amuvatinib, a receptor tyrosine kinase inhibitor, and erlotinib, an epidermal growth factor inhibitor, was assessed for its ability to differentially modulate growth signaling in pathway diverse LNCaP (PTEN⁻) and DU-145 (PTE
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Edelmann, Stephanie. "Development of DC-specific lentiviral vectors: novel DC-targeting strategies for immunomodulation." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-134453.

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Stresman, G. "Operational strategies for the identification and targeting of hotspots of malaria transmission." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2305255/.

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Heterogeneous malaria exposure may result in distinct clusters of higher malaria burden, or hotspots, across space and time. Targeting control programs to these areas may be highly efficient, however, operationally attractive approaches for identifying hotspots are needed for any such program to be sustained by local malaria control programs. The principal aim of this project was to investigate the ability of convenient sampling to identify hotspots of malaria transmission in a low endemic transmission setting in the western Kenyan highlands: 1) The boundaries of hotspots, and associated uncer
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Drobnitzky, Neele. "Novel therapeutic strategies for targeting EGFR mutated non-small cell lung cancer." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:53788e9e-20f1-44da-bb47-7da5884f3093.

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Background: NSCLC patients with EGFR M+ tumours have marked clinical responses to EGFR-TKIs. Most patients experience tumour regrowth, as drug resistance emerges through on-target secondary EGFR-mutations or other activating mutations that reactivate the downstream signalling. However, a significant number of patients become drug resistant through unknown mechanisms of resistance and these currently represent an area of high unmet clinical need. In this work, we aim to understand biological responses to sustained EGFR inhibition in EGFR mutated NSCLC cells, to generate EGFR-TKI resistant cell
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Batisse, Cornélie. "Targeting strategies using B-subunit of Shiga toxin : innovative drug-delivery systems." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB220.

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Les stratégies thérapeutiques mises en place contre le cancer ont de nos jours besoin de nouveaux médicaments, à la fois plus actifs que ceux déjà existants et induisant moins d’effets secondaires. Ces nouvelles stratégies visent à cibler spécifiquement les cellules cancéreuses. Parmi ces stratégies, ces travaux de thèse concernent la vectorisation active, à l’aide d’un vecteur protéique dérivé de la toxine de Shiga, STxB. STxB reconnait spécifiquement son récepteur biologique Gb3, surexprimé à la surface des cellules cancéreuses humaines. Ce projet de recherche porte sur la conception et la s
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Jaroš, Martin. "Návrh marketingové strategie značky Schwarzwolf outdoor." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2011. http://www.nusl.cz/ntk/nusl-223075.

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The thesis describes a proposal of iMi Partner, a.s. marketing strategies for entering new markets with Schwarzwolf outdoor brand. The proposal section contains a summary measure for the achievement of expanding the product into new markets and for strengthening the brand. The proposed section is preceded by a strategic analysis of external and internal environment of the company. Part of this work is devoted to the marketing as its theoretical starting point.
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Alam, Syeda Tamanna. "Novel Approaches for Enhancing Resistance to Fusarium graminearum in Arabidopsis and Wheat by Targeting Defense and Pathogenicity Factors." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703417/.

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Fusarium head blight (FHB) is an important disease of small grain cereals including wheat that affects grain quality and yield. The fungus Fusarium graminearum (Fg) is the major agent of this disease. Lack of natural resistance has limited ability to control wheat losses to this disease. Developing new approaches is critical for increasing host plant resistance to this fungus. This work has identified four processes that can be targeted for enhancing host plant resistance to FHB. The first involves targeting the pattern-triggered immunity mechanism to promote host plant resistance. Two othe
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Harant, Vladimír. "Marketingová strategie pre podnik Ing. Augustín Dobiš AD SPECTRUM." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222443.

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Diploma theses represents project of marketing a communication strategy of manufacturing company. This work includes situation analysis of present situation including evaluation of weaknesses and streghts of the company, opportunities and threaths and on the basis of this analysis particular marketing and communication strategy, budget and timing has been designed.
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Štěpánek, Petr. "Marketingová strategie rozvoje podnikání." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2013. http://www.nusl.cz/ntk/nusl-224168.

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This master’s thesis tells about marketing strategy of business development. The first section describes marketing as the primary function of modern organisation and its influence on development strategy. The following section of analysis evaluates the effects of external & internal factors on the strategy of development, which is the subject of the last section of this thesis.
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Goldnau, Daniela. "New strategies for the application of Adeno-Associated Virus type 2 targeting vectors." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-73456.

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Matthew, Ashley N. "Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/969.

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The Hepatitis C virus (HCV) NS3/4A protease inhibitors (PIs) have become a mainstay of newer all-oral combination therapies. Despite improvements in potency of this inhibitor class, drug resistance remains a problem with the rapid emergence of resistance-associated substitutions (RASs). In this thesis I elucidate the molecular mechanisms of drug resistance for PIs against a resistant variant and apply insights toward the design of inhibitors with improved resistance profiles using structural, biochemical and computational techniques. Newer generation PIs retain high potency against most single
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Ahmed-Ebbiary, Amro. "Developing novel therapeutic strategies for targeting the p53 pathway in renal cell carcinoma." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/18973/.

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Renal cell carcinoma (RCC) is a notoriously difficult cancer to treat. RCC has an unpredictable course, is radio- and chemo-resistant and survival in response to treatment with current therapies for the metastatic disease is generally very poor. This underscores the necessity for novel therapeutics for this condition. The tumour suppressor p53 is rarely mutated in RCC and up-regulation of p53 and its negative regulator, MDM2, has recently been shown to be an independent prognostic indicator for patients with poor outcome. The function of p53 in RCC cells in culture appears to be partially inta
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Kwan, Tony King-Tak. "A mechanistic analysis of strategies targeting innate immunity to prevent kidney allograft rejection." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21293.

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Renal transplantation remains the optimal method of renal replacement therapy for patients with end-stage renal disease, but long-term outcomes are poor. Both immune and non-immune mechanisms contribute to the development of allograft injury and failure. Therefore, therapeutic strategies to improve long-term transplant recipient outcomes are needed. Previous work from our group found that the absence of MyD88, a key signalling adaptor molecule of the Toll-like receptor pathway involved in innate immunity, induces donor-specific tolerance in our model of renal allograft transplantation, and is
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Klimovich, Boris [Verfasser], and Oleg [Akademischer Betreuer] Timofeev. "Exploring mutant p53 targeting strategies for cancer therapy / Boris Klimovich ; Betreuer: Oleg Timofeev." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1204199825/34.

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Cassella, P. "NUOVE STRATEGIE DI STUDIO DELLA BIOGENESI DELLE MEMBRANE: IL PROBLEMA DEL CORRETTO 'TARGETING' POST-TRADUZIONALE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229430.

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Tail-anchored (TA) proteins have a transmembrane domain near the C terminus and an N-terminal cytosolic moiety; because of this topology they do not have access to the SRP-mediated co-translational pathway for insertion into the ER, and can be integrated in their target membranes only posttranslationally. The TRC40/Get3 system is known to play an important role in post-translational targeting to the ER, but some TA proteins can integrate into lipid bilayers independently from this system, yet undergo precise targeting in vivo. The best studied example of this phenomenon is given by cytochrome
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Krejčí, Andrea. "Návrh marketingové strategie." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377577.

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The diploma thesis deals with the analysis of the current situation of the company Studyline s. r .o. and the innovation proposal, which is the realization of the language school in Brno. The aim of the thesis is to design a functional marketing strategy that will be applicable in real terms as early as 2018. The thesis also includes a thorough analysis of the internal and external environment, which is summarized by SWOT analysis. The work also evaluates the project's risks, thorough monitoring of the competition, and, in the final stage, marketing strategies for language schools, including t
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