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1

Chiang, W. C., J. C. Tsai, S. Y. Chen, C. Y. Hsu, C. T. Wu, L. J. Teng, and P. R. Hsueh. "Mycotic Aneurysm Caused by Streptococcus constellatus subsp. constellatus." Journal of Clinical Microbiology 42, no. 4 (April 1, 2004): 1826–28. http://dx.doi.org/10.1128/jcm.42.4.1826-1828.2004.

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2

Tabata, Atsushi, Yuji Sato, Kentaro Maya, Kota Nakano, Ken Kikuchi, Robert A. Whiley, Kazuto Ohkura, Toshifumi Tomoyasu, and Hideaki Nagamune. "A streptolysin S homologue is essential for β-haemolytic Streptococcus constellatus subsp. constellatus cytotoxicity." Microbiology 160, no. 5 (May 1, 2014): 980–91. http://dx.doi.org/10.1099/mic.0.075580-0.

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Streptococcus constellatus is a member of the Anginosus group streptococci (AGS) and primarily inhabits the human oral cavity. S. constellatus is composed of three subspecies: S. constellatus subsp. constellatus (SCC), S. constellatus subsp. pharyngis and the newly described subspecies S. constellatus subsp. viborgensis. Although previous studies have established that SCC contains β-haemolytic strains, the factor(s) responsible for β-haemolysis in β-haemolytic SCC (β-SCC) has yet to be clarified. Recently, we discovered that a streptolysin S (SLS) homologue is the β-haemolytic factor of β-haemolytic Streptococcus anginosus subsp. anginosus (β-SAA), another member of the AGS. Furthermore, because previous studies have suggested that other AGS species, except for Streptococcus intermedius, do not possess a haemolysin(s) belonging to the family of cholesterol-dependent cytolysins, we hypothesized that, as with β-SAA, the SLS homologue is the β-haemolytic factor of β-SCC, and therefore aimed to investigate and characterize the haemolytic factor of β-SCC in the present study. PCR amplification revealed that all of the tested β-SCC strains were positive for the sagA homologue of SCC (sagA SCC). Further investigations using β-SCC strain W277 were conducted to elucidate the relationship between sagA SCC and β-haemolysis by constructing sagA SCC deletion mutants, which completely lost β-haemolytic activity. This loss of β-haemolytic activity was restored by trans-complementation of sagA SCC. Furthermore, a co-cultivation assay established that the cytotoxicity of β-SCC was clearly dependent on the presence of sagA SCC. These results demonstrate that sagA SCC is the factor responsible for β-SCC β-haemolysis and cytotoxicity.
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3

Nalmas, Sandhya, Eliahu Bishburg, and Trini Chan. "Streptococcus constellatusand Prevotella bivia Penile Abscess." Scientific World JOURNAL 7 (2007): 1631–33. http://dx.doi.org/10.1100/tsw.2007.240.

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Streptococcus constellatus(S. constellatus) is known to cause abscesses in the oral, genitourinary, and gastrointestinal tracts, frequently in association with anaerobic bacteria. We report a rare case ofS. constellatusandPrevotella bivia(P. bivia) causing a penile abscess, which was successfully treated with surgical drainage and antibiotic treatment.
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4

Segrelles Calvo, G., C. Cisneros, R. Gómez-Punter, J. A. García Romero de Tejada, and O. Rajas. "Empiema causado por Streptococcus constellatus." Revista de Patología Respiratoria 15, no. 1 (January 2012): 30–32. http://dx.doi.org/10.1016/s1576-9895(12)70136-4.

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5

Revilla-Martí, P., and C. López-Núñez. "Empiema pleural por Streptococcus constellatus." Revista Clínica Española 211, no. 11 (December 2011): 612–13. http://dx.doi.org/10.1016/j.rce.2011.04.007.

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6

Sangil González, A., M. Sandiumenge Durán, I. López Martínez, I. Melián Domínguez, and F. González López. "Absceso hepático por Streptococcus constellatus." Anales de Pediatría 78, no. 2 (February 2013): 133–34. http://dx.doi.org/10.1016/j.anpedi.2012.05.016.

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7

Gatti, Luis, Dolores Lovera, Silvio Apodaca, Claudia Zárate, Juan Irala, Gabriela Sanabria, and Antonio Arbo. "Streptococcus constellatus: uncommon cause of pleural empyema." Revista del Instituto de Medicina Tropical 14, no. 1 (June 30, 2019): 40–43. http://dx.doi.org/10.18004/imt/201914140-43.

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8

Roca, B., A. Romero, and E. Simón. "Acute meningitis caused by Streptococcus constellatus." Journal of Infection 37, no. 1 (July 1998): 88. http://dx.doi.org/10.1016/s0163-4453(98)91249-x.

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9

Fuentes Olmo, Javier, María Ruiz Mariscal, Rafael Uribarrena Amezaga, and Teresa Omiste Sanvicente. "Peritonitis bacteriana espontánea por streptococcus constellatus." Gastroenterología y Hepatología 29, no. 9 (November 2006): 595–96. http://dx.doi.org/10.1157/13094363.

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10

Tymon-Rosario, Joan, Jessica M. Atrio, Hyun Ah Yoon, David Erlichman, and Veronica Lerner. "Streptococcus constellatus Peritonitis and Subsequent Septic Shock following Intrauterine Device Removal." Case Reports in Obstetrics and Gynecology 2019 (August 4, 2019): 1–5. http://dx.doi.org/10.1155/2019/6491617.

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Background. Previous reports have described cases of abscess formation by Streptococcus constellatus involving the oral cavity, gastrointestinal tract, and septic thrombophlebitis of the right ovarian vein with subsequent bacteremia and septic shock. Ascending infection from the genital tract to the fallopian tubes resulting in peritonitis from Streptococcus constellatus is a rare clinical circumstance where there is minimal information in the literature to guide its diagnosis, management, and expected prognosis. Case. A 36-year-old G3P0111 developed a tubo-ovarian abscess two weeks after intrauterine device (IUD) removal and then rapidly decompensated with septic shock from peritonitis due to Streptococcus constellatus infection. The patient was also newly diagnosed with diabetes and in diabetic ketoacidosis (DKA) on presentation. She received broad-spectrum antibiotic coverage and required two exploratory surgical procedures to obtain source control. Two Interventional Radiology- (IR-) guided drainage procedures were subsequently performed to drain remaining fluid collections. Her recovery involved a prolonged ICU stay. On hospital day seventy-three, after receiving approximately 8 weeks of antibiotics and the above noted procedures the patient was discharged to a subacute rehabilitation facility. Conclusion. Streptococcus constellatus is a highly pathogenic organism once a systemic septic infection has become established that can cause an ascending genital tract infection resulting in tubo-ovarian abscess formation, peritonitis, and septic shock.
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11

Coykendall, A. L., P. M. Wesbecher, and K. B. Gustafson. ""Streptococcus milleri" Streptococcus constellatus, and Streptococcus intermedius Are Later Synonyms of Streptococcus anginosus." International Journal of Systematic Bacteriology 37, no. 3 (July 1, 1987): 222–28. http://dx.doi.org/10.1099/00207713-37-3-222.

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12

Chrastek, D., S. Hickman, D. Sitaranjan, I. Vokshi, O. Kakisi, J. Kadlec, W. Bartosik, F. Van Tornout, and V. Kouritas. "Streptococcus constellatus Causing Empyema and Sepsis, Necessitating Early Surgical Decortication." Case Reports in Infectious Diseases 2020 (July 14, 2020): 1–4. http://dx.doi.org/10.1155/2020/4630809.

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Streptococcus constellatus is an oropharyngeal commensal Gram-positive coccus, frequently associated with the respiratory tract. S. constellatus is part of the Streptococcus anginosus or milleri group, which has traditionally been considered to have propensity to cause empyema and purulent abscesses, a property that is sometimes overlooked as the severity of infections it causes may have a varying degree. In this case, we present the case of a 54-year-old male with known liver cirrhosis who developed a severe empyema during an acute liver failure episode, requiring extensive decortication and prolonged hospital admission.
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13

Clarridge, Jill E., Cheryl Osting, Mehri Jalali, Janet Osborne, and Michael Waddington. "Genotypic and Phenotypic Characterization of “Streptococcus milleri” Group Isolates from a Veterans Administration Hospital Population." Journal of Clinical Microbiology 37, no. 11 (1999): 3681–87. http://dx.doi.org/10.1128/jcm.37.11.3681-3687.1999.

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Because identification of the species within the “Streptococcus milleri” group is difficult for the clinical laboratory as the species share overlapping phenotypic characteristics, we wished to confirm biochemical identification with identification by 16S rRNA gene sequence analysis. Ninety-four clinical isolates previously identified as the “Streptococcus milleri” group were reclassified as S. anginosus, S. constellatus, or S. intermedius with the API 20 Strep system (bioMerieux Vikek, Hazelton, Mo.) and the Fluo-card (Key Scientific, Round Rock, Tex.). In addition, we determined the Lancefield group, hemolysis, colony size, colony texture, repetitive extragenic palindromic PCR (rep-PCR) pattern, and cellular fatty acid (CFA) profile (MIDI, Newark, Del.). 16S rRNA gene sequence analysis with 40 selected representative strains showed three distinct groups, with S. constellatus andS. intermedius found to be more closely related to each other than to S. anginosus, and further distinguished a biochemically distinct group of urogenital isolates within the S. anginosus group of isolates. Except for strains unreactive with the Fluo-card (8%), all S. anginosus and S. intermedius strains identified by sequencing were similarly identified by biochemical testing. However, 23% of the selectedS. constellatus isolates identified by sequencing (9% of all S. constellatus isolates) would have been identified asS. anginosus or S. intermedius by biochemical tests. Although most S. anginosus strains formed one unique cluster by CFA analysis and most S. constellatus strains showed similar rep-PCR patterns, neither method was sufficiently dependable for identification. Whereas Lancefield group or lactose fermentation did not correspond to sequence or biochemical type,S. constellatus was most likely to be beta-hemolytic andS. intermedius was most likely to have a dry colony type. The most frequent isolate in our population was S. constellatus, followed by S. anginosus. There was an association of S. anginosus with a gastrointestinal or urogenital source, and there was an association of S. constellatus and S. intermedius with both the respiratory tract and upper-body abscesses.
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14

Ortiz de Saracho, J., S. Barbancho, and J. L. Mostaza. "Mediastinitis y empiema pleural por Streptococcus constellatus." Archivos de Bronconeumología 40, no. 12 (January 2004): 602. http://dx.doi.org/10.1016/s0300-2896(04)75599-4.

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15

Faden, Howard, and Mustafa Mohmand. "Infections Associated With Streptococcus Constellatus in Children." Pediatric Infectious Disease Journal 36, no. 11 (November 2017): 1099–100. http://dx.doi.org/10.1097/inf.0000000000001646.

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16

Ortiz de Saracho, J., S. Barbancho, and JL Mostaza. "Mediastinitis y empiema pleural por Streptococcus constellatus." Archivos de Bronconeumología 40, no. 12 (December 2004): 602. http://dx.doi.org/10.1157/13068805.

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17

De Martino, Luisa, Sandra Nizza, Claudio de Martinis, Valentina Foglia Manzillo, Valentina Iovane, Orlando Paciello, and Ugo Pagnini. "Streptococcus constellatus-associated pyoderma in a dog." Journal of Medical Microbiology 61, no. 3 (March 1, 2012): 438–42. http://dx.doi.org/10.1099/jmm.0.033845-0.

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18

Carrère, S., É. Deneve, H. Bouyabrine, J. P. Marchand, and F. Navarro. "Streptococcus constellatus, abcès épidural et fistule colovésicale." Gastroentérologie Clinique et Biologique 32, no. 8-9 (August 2008): 786–87. http://dx.doi.org/10.1016/j.gcb.2008.05.008.

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19

Manresa-Manresa, Francisco, María Alcázar Iribarren-Marín, and Francisco Tadeo Gómez-Ruiz. "Infección de endoprótesis aórtica por Streptococcus constellatus." Cardiocore 51, no. 3 (July 2016): 123–25. http://dx.doi.org/10.1016/j.carcor.2014.07.005.

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20

Nourani, Mona, and Malliswari Challapalli. "Streptococcus constellatus Lymphadenitis in Chronic Granulomatous Disease." Journal of Clinical Immunology 33, no. 2 (October 18, 2012): 309. http://dx.doi.org/10.1007/s10875-012-9818-5.

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21

Morinaga, Yoshitomo, Katsunori Yanagihara, Hiroshi Gyotoku, Kazuhiro Oshima, Koichi Izumikawa, Naoya Yamasaki, Hiroshi Kakeya, et al. "Pulmonary artery pseudoaneurysm caused by Streptococcus constellatus." International Journal of Infectious Diseases 17, no. 11 (November 2013): e1064-e1066. http://dx.doi.org/10.1016/j.ijid.2013.03.013.

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22

Jensen, Anders, Tomonori Hoshino, and Mogens Kilian. "Taxonomy of the Anginosus group of the genus Streptococcus and description of Streptococcus anginosus subsp. whileyi subsp. nov. and Streptococcus constellatus subsp. viborgensis subsp. nov." International Journal of Systematic and Evolutionary Microbiology 63, Pt_7 (July 1, 2013): 2506–19. http://dx.doi.org/10.1099/ijs.0.043232-0.

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The Anginosus group of the genus Streptococcus has been the subject of much taxonomic confusion, which has hampered the full appreciation of its clinical significance. The purpose of this study was to critically re-examine the taxonomy of the Anginosus group, with special attention to β-haemolytic, Lancefield group C strains, using multilocus sequence analysis (MLSA) combined with 16S rRNA gene sequence and phenotypic analyses. Phylogenetic analysis of concatenated sequences of seven housekeeping genes previously used for examination of viridans streptococci distinguished seven distinct and coherent clusters in the Anginosus group. Analyses of 16S rRNA gene sequences and phenotypic characters supported the MLSA clustering and currently recognized taxa of the Anginosus group. Single gene analyses showed considerable allele sharing between species, thereby invalidating identification based on single-locus sequencing. Two novel clusters of β-haemolytic, Lancefield group C strains within the Streptococcus constellatus and Streptococcus anginosus species and isolated from patients with sore throat showed sufficient phylogenetic distances from other clusters to warrant status as novel subspecies. The novel cluster within S. anginosus was identified as the previously recognized DNA homology cluster, DNA group 2. The names S. anginosus subsp. whileyi subsp. nov. (type strain CCUG 39159T = DSM 25818T = SK1267T) and S. constellatus subsp. viborgensis subsp. nov. (type strain SK1359T = CCUG 62387T = DSM 25819T) are proposed.
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23

Jacobs, Jan A., Henk G. Pietersen, Ellen E. Stobberingh, and Peter B. Soeters. "Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedius Clinical Relevance, Hemolytic and Serologic Characteristics." American Journal of Clinical Pathology 104, no. 5 (November 1, 1995): 547–53. http://dx.doi.org/10.1093/ajcp/104.5.547.

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24

Glazunova, Olga O., Didier Raoult, and Véronique Roux. "Partial recN gene sequencing: a new tool for identification and phylogeny within the genus Streptococcus." International Journal of Systematic and Evolutionary Microbiology 60, no. 9 (September 1, 2010): 2140–48. http://dx.doi.org/10.1099/ijs.0.018176-0.

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Partial sequences of the recN gene (1249 bp), which encodes a recombination and repair protein, were analysed to determine the phylogenetic relationship and identification of streptococci. The partial sequences presented interspecies nucleotide similarity of 56.4–98.2 % and intersubspecies similarity of 89.8–98 %. The mean DNA sequence similarity of recN gene sequences (66.6 %) was found to be lower than those of the 16S rRNA gene (94.1 %), rpoB (84.6 %), sodA (74.8 %), groEL (78.1 %) and gyrB (73.2 %). Phylogenetically derived trees revealed six statistically supported groups: Streptococcus salivarius, S. equinus, S. hyovaginalis/S. pluranimalium/S. thoraltensis, S. pyogenes, S. mutans and S. suis. The ‘mitis’ group was not supported by a significant bootstrap value, but three statistically supported subgroups were noted: Streptococcus sanguinis/S. cristatus/S. sinensis, S. anginosus/S. intermedius/S. constellatus (the ‘anginosus’ subgroup) and S. mitis/S. infantis/S. peroris/S. oralis/S. oligofermentans/S. pneumoniae/S. pseudopneumoniae. The partial recN gene sequence comparison highlighted a high percentage of divergence between Streptococcus dysgalactiae subsp. dysgalactiae and S. dysgalactiae subsp. equisimilis. This observation is confirmed by other gene sequence comparisons (groEL, gyrB, rpoB and sodA). A high percentage of similarity was found between S. intermedius and S. constellatus after sequence comparison of the recN gene. To study the genetic diversity among the ‘anginosus’ subgroup, recN, groEL, sodA, gyrB and rpoB sequences were determined for 36 clinical isolates. The results that were obtained confirmed the high genetic diversity within this group of streptococci.
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Ryu, Yong Suc, Jae Hyung Lee, Byung Hoon Lee, Sang Hoon Kim, Dong Jin Yang, Sang Ryol Ryu, Yun Hwa Yu, Mi Youn Cheong, and Jeong Don Chae. "A Case of Empyema Caused by Streptococcus Constellatus." Tuberculosis and Respiratory Diseases 66, no. 6 (2009): 463. http://dx.doi.org/10.4046/trd.2009.66.6.463.

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26

Worlitzsch, D., A. L. Jaschinski, M. Stotz, and M. Borneff-Lipp. "119 Contamination of CF sputum with Streptococcus constellatus." Journal of Cystic Fibrosis 12 (June 2013): S78. http://dx.doi.org/10.1016/s1569-1993(13)60261-1.

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27

Ortiz de Saracho, J., S. Barbancho, and J. L. Mostaza. "Mediastinitis and Thoracic Empyema Caused by Streptococcus constellatus." Archivos de Bronconeumología ((English Edition)) 40, no. 12 (December 2004): 602. http://dx.doi.org/10.1016/s1579-2129(06)60382-0.

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28

Puerta Louro, Rubén, Laura González Vázquez, Francisco Fernández Fernández, Susana Araujo Fernández, Hector Enríquez Gómez, Luis Novoa Lamazares, Alejandra Arca Blanco, and Javier De La Fuente Aguado. "STREPTOCOCCUS CONSTELLATUS AS CAUSATIVE AGENT OF THORACIC INFECTIONS." European Journal of Internal Medicine 22 (October 2011): S77. http://dx.doi.org/10.1016/s0953-6205(11)60317-8.

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29

Marinella, M. A. "Streptococcus constellatus Endocarditis Presenting as Acute Embolic Stroke." Clinical Infectious Diseases 24, no. 6 (June 1, 1997): 1271. http://dx.doi.org/10.1093/clinids/24.6.1271.

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30

Handrick, W., R. Schille, A. Hemprich, and F. B. Spencker. "Dentogene Infektion durch Streptococcus constellatus bei einem Kind." Klinische Pädiatrie 213, no. 5 (September 2001): 299–300. http://dx.doi.org/10.1055/s-2001-17224.

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31

Nogueira, Rúben Malcata, Carolina Vasconcelos, and Nelson Teixeira. "A Rare Cause of Hand Infection: Streptococcus Constellatus." Revista Iberoamericana de Cirugía de la Mano 48, no. 01 (May 2020): 053–55. http://dx.doi.org/10.1055/s-0040-1712093.

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AbstractHand infections represent common medical and surgical challenges that endanger delicate structures with severe consequences if not promptly addressed. Early identification and management are essential to achieve optimal outcomes. To the best of our knowledge this is the first reported case caused by Streptococcus constellatus, in which a severe periungueal infection evolved rapidly with septic thrombosis of digital vessels and culminated in amputation. This microorganism belongs to a group of commensal bacteria, Streptococcus milleri, that causes dental, peritonsillar and sinus abscesses. When bacteriemia outbursts, distant abscesses may form or endocarditis may ensue. A missed diagnosis and treatment can induce important morbidities, often delayed by the difficult isolation of the agent in the laboratory and its complex mechanisms of antibacterial resistance. This article focus on the importance of identifying serious hand infections requiring urgent or emergent treatment, since delayed or inadequate identification and management can lead to important and permanent deficits.
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32

Li, Emily, Alberto Distefano, and Mahsa Sohrab. "Necrotizing Orbital Cellulitis Secondary to Odontogenic Streptococcus constellatus." Ophthalmic Plastic and Reconstructive Surgery 34, no. 5 (2018): e160-e162. http://dx.doi.org/10.1097/iop.0000000000001185.

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33

Shah, Anish N., Benoy N. Shah, Sarah Glover, and Luke Herbert. "Bilateral foveal cysts secondary to Streptococcus constellatus endocarditis." International Ophthalmology 33, no. 3 (November 3, 2012): 315–17. http://dx.doi.org/10.1007/s10792-012-9660-z.

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Yoshino, Yusuke, Yoshitaka Kimura, Takashi Sakai, Takeyuki Kanzaki, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, and Yasuo Ota. "Infective endocarditis due to a rare pathogen, Streptococcus constellatus, in a patient with gingivitis: A case report and review of the literature." Open Medicine 8, no. 4 (August 1, 2013): 489–92. http://dx.doi.org/10.2478/s11536-013-0167-4.

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AbstractA 78-year-old Japanese man with a 5-day history of fever (∼38°C) and decreased appetite was admitted to our hospital. Transesophageal echocardiography revealed aortic valve vegetation. Streptococcus constellatus was detected from a blood culture. An antibiotic sensitive to this strain was administered for 6 weeks, and the patient has been well for 6 months without any sign of relapse. A review of all documented cases of infective endocarditis due to S. constellatus revealed nonspecific initial symptoms, especially coughing, and complications of abscess formation and septic embolisation. Clinicians should carefully consider the choice of antibiotic agents in the treatment of infective endocarditis due to S. constellatus, because penicillin-resistant strains have been documented in some cases.
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35

Jacobs, Jan A., and Ellen E. Stobberingh. "In-vitro antimicrobial susceptibility of the ‘Streptococcus milleri’ group (Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedius)." Journal of Antimicrobial Chemotherapy 37, no. 2 (1996): 371–75. http://dx.doi.org/10.1093/jac/37.2.371.

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36

Whiley, R. A., H. Fraser, J. M. Hardie, and D. Beighton. "Phenotypic differentiation of Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus strains within the "Streptococcus milleri group"." Journal of Clinical Microbiology 28, no. 7 (1990): 1497–501. http://dx.doi.org/10.1128/jcm.28.7.1497-1501.1990.

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37

Zhang, Michael, Lifang Yan, Guan Zhu, Michael Holifield, Donna Todd, and Shuping Zhang. "Streptococcus troglodytidis sp. nov., isolated from a foot abscess of a chimpanzee (Pan troglodytes)." International Journal of Systematic and Evolutionary Microbiology 63, Pt_2 (February 1, 2013): 449–53. http://dx.doi.org/10.1099/ijs.0.038133-0.

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A facultative anaerobic, non-motile, non-spore-forming, Gram-positive-staining, coccus-shaped bacterium was isolated from an abscess on the right foot of a chimpanzee (Pan troglodytes). The colonies were β-haemolytic. Catalase and oxidase activities were negative. The Lancefield group B antigen was expressed. On the basis of morphological and biochemical characteristics, the bacterium was tentatively identified as a streptococcal species. 16S rRNA gene sequence analysis indicated that the bacterium shared 96.7 %, 96.4 %, 96.1 %, 95.8 % and 95.7 % sequence similarities with Streptococcus gordonii , S. cristatus , S. intermedius , S. anginosus and S. constellatus , respectively. Phylogenetic analyses based on the sequences of the 16S rRNA gene and housekeeping genes encoding d-alanine : d-alanine ligase (ddl), the β-subunit of RNA polymerase (rpoB) and manganese-dependent superoxide dismutase (sodA) revealed that the bacterium represented a novel species closely related to, albeit different from, S. gordonii , S. cristatus and the anginosus streptococci. The name Streptococcus troglodytidis sp. nov. is proposed. The type strain is M09-11185T ( = ATCC BAA-2337T = KCTC 33006T).
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38

WHILEY, R. A., and D. BEIGHTON. "Emended Descriptions and Recognition of Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus as Distinct Species." International Journal of Systematic Bacteriology 41, no. 1 (January 1, 1991): 1–5. http://dx.doi.org/10.1099/00207713-41-1-1.

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39

SW, Lim, Lim HY, Kannaiah T, and Zuki Z. "Streptococcus Constellatus Spondylodiscitis in a Teenager: A Case Report." Malaysian Orthopaedic Journal 11, no. 3 (November 1, 2017): 50–52. http://dx.doi.org/10.5704/moj.1711.004.

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40

Kontogianidis, Kosmas, Savas Deftereos, Maria Panopoulou, Anna Ramatani, Theodosios Birbilis, Athanassios Chatzimichael, and Elpis Mantadakis. "Subdural empyema of odontogenic origin due to Streptococcus constellatus." Journal of Pediatric Infectious Diseases 09, no. 01 (July 28, 2015): 047–50. http://dx.doi.org/10.3233/jpi-140409.

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Datta, Priya, Gursimram Kaur Mohi, Jagdish Chander, and Ashok K. Attri. "Streptococcus constellatus causing multiple liver abscesses: an elusive pathogen." Tropical Doctor 48, no. 2 (July 23, 2017): 154–56. http://dx.doi.org/10.1177/0049475517721817.

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42

Chheda, Lena V. "Endogenous Endophthalmitis With Brain Abscesses Caused by Streptococcus constellatus." Archives of Ophthalmology 129, no. 4 (April 11, 2011): 512. http://dx.doi.org/10.1001/archophthalmol.2011.59.

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43

Scoon, Joanna, Jennifer Duke, and Maryam Kaous. "Pyopneumothorax With Bronchopleural Fistula Secondary to Streptococcus Constellatus Infection." Chest 152, no. 4 (October 2017): A533. http://dx.doi.org/10.1016/j.chest.2017.08.562.

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44

Pinilla-Monsalve, Gabriel D., Daniel F. Torres-Cutiva, and Juan P. Fernández-Cubillos. "Atypical Streptococcal Meningitis with Fatal Cerebrovascular Complications: A Case Report." Infectious Disease Reports 12, no. 3 (November 21, 2020): 87–96. http://dx.doi.org/10.3390/idr12030018.

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Bacterial meningitis is an infectious pathology that remains a public health challenge. The most frequent etiological agent is Streptococcus pneumoniae, which is also associated with higher rates of mortality and sequels. However, less is known about the clinical presentation of atypical non-pneumoniae streptococcal meningitis. Here, we studied a 23-year-old man with no medical background who presented with projectile vomiting, states of consciousness alteration, unilateral cranial nerve palsy, and meningeal signs. Neuroimaging showed tonsillar herniation, regions of empyema, right transverse and sigmoid sinuses thrombosis, and multiple arterial subcortical infarcts. Cerebrospinal fluid suggested bacterial infection; blood and abscess cultures were positive for Streptococcus constellatus. The patient received antibiotics with no clinical improvement. He deteriorated over the following days, the abolishment of brainstem reflexes was observed, and brain death was declared. Streptococcal meningitis produced by atypical species is a potential cause of lethal cerebrovascular complications, even in immunocompetent patients.
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45

Mora-Palma, José Carlos, Vicente Guillot-Suay, María del Mar Sánchez Gila, and José Gutiérrez-Fernández. "Pelvic inflammatory disease by Streptococcus constellatus. Clinical experience and a review." Revista Española de Quimioterapia 33, no. 4 (June 9, 2020): 285–88. http://dx.doi.org/10.37201/req/020.2020.

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46

KOBO, O., S. NIKOLA, Y. GEFFEN, and M. PAUL. "The pyogenic potential of the different Streptococcus anginosus group bacterial species: retrospective cohort study." Epidemiology and Infection 145, no. 14 (August 14, 2017): 3065–69. http://dx.doi.org/10.1017/s0950268817001807.

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SUMMARYStreptococcus anginosus Group (SAG) bacteria are common causes of pyogenic infections (PIs). We examined the association between SAG species and the presence of a PI through a retrospective, observational, cohort study, between the years 2009 and 2015. All adults with clinically significant SAG infections in one hospital in Israel were assessed for association between SAG species and the presence of a PI defined as an abscess, empyema, or deep/organ space surgical site infection. Risk factors for PI were assessed using multivariate backward stepwise logistic regression analysis. We identified 263 patients with significant SAG infections, 182 (69%) of which were caused by S. anginosus, 45 (17·1%) by Streptococcus constellatus and 36 (13·7%) by Streptococcus intermedius. The mean age of the patients was 56·8 ± 19·1 years. PIs were identified among 160 (60%) of the patients and were mostly non-bacteraemic (147/160, 91·8%), while most non-PI patients had bacteraemia (70/103, 68%). S. anginosus and S. constellatus were associated with a significantly lower incidence of PI than S. intermedius, OR 0·18 (95% CI 0·06–0·53) and 0·14 (0·04–0·48), respectively. Patients with PI were younger and, in general, had less co-morbidities. S. intermedius was associated with pyogenic non-bacteraemic infections, while S. anginosus and S. constellatus were associated with bacteraemia with no abscess or empyema formation. These data may indicate differences in virulence mechanisms of these SAG bacteria.
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47

Whiley, R. A., D. Beighton, T. G. Winstanley, H. Y. Fraser, and J. M. Hardie. "Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus (the Streptococcus milleri group): association with different body sites and clinical infections." Journal of Clinical Microbiology 30, no. 1 (1992): 243–44. http://dx.doi.org/10.1128/jcm.30.1.243-244.1992.

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48

Hartmeyer, Gitte N., and Ulrik S. Justesen. "Direct 16S rRNA gene sequencing of polymicrobial culture-negative sampleswith analysis of mixed chromatograms." Journal of Medical Microbiology 59, no. 4 (April 1, 2010): 486–88. http://dx.doi.org/10.1099/jmm.0.017269-0.

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Two cases involving polymicrobial culture-negative samples were investigatedby 16S rRNA gene sequencing, with analysis of mixed chromatograms. Fusobacteriumnecrophorum, Prevotella intermedia and Streptococcus constellatus were identified from pleural fluid in a patient with Lemierre'ssyndrome and Neisseria meningitidis and Escherichia coliwere identified from a petechia in a patient with meningococcal disease.
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Lee, Ji Hye, Hyun Joo Heo, Ki Man Kim, Han Gyeol Lee, Seung Min Baek, and Da Wa Jung. "Herpes zoster in the ophthalmic branch of the trigeminal ganglia obscuring cavernous sinus thrombosis due to Streptococcus constellatus ssp. constellatus." Anesthesia and Pain Medicine 15, no. 2 (April 30, 2020): 205–8. http://dx.doi.org/10.17085/apm.2020.15.2.205.

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Background: Herpes zoster ophthalmicus (HZO) is an infectious disease that results from the reactivation of latent varicella zoster virus in the ophthalmic branch of the trigeminal ganglia. HZO manifests with herpes zoster-like symptoms such as rash with or without signs of ocular involvement. Cavernous sinus thrombosis (CST) is a life-threatening condition accompanied by signs and symptoms involving the eyes and the cranial nerves. Case: We report a case of septic cavernous sinus thrombosis (caused by Streptococcus constellatus ssp. constellatus) which was masked by the simultaneous occurrence of HZO in this patient, resulting in delayed diagnosis. Conclusions: CST may be obscured by HZO, prompt diagnosis and treatment is necessary when such case arrive.
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Shimada, Midori, Yoshitomo Morinaga, Takeshi Kitazaki, Minoru Fukuda, Kohji Hashiguchi, Katsunori Yanagihara, and Shigeru Kohno. "A Severe Case of Lemierre Syndrome with Streptococcus constellatus Infection." Japanese Journal of Infectious Diseases 67, no. 6 (2014): 488–89. http://dx.doi.org/10.7883/yoken.67.488.

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