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Dissertations / Theses on the topic 'Streptococcus pneumoniae'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Bazaz, Rohit. "The effect of Streptococcus pneumoniae pneumonia on atherosclerosis." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16897/.

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2

Koppe, Uwe Moritz Eberhard. "Role of type I interferons in Streptococcus pneumoniae pneumonia." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16532.

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Streptococcus pneumoniae ist die häufigste Ursache für ambulant erworbene Pneumonien weltweit. Daher müssen die Wirts-Pathogen-Interaktionen erforscht werden, um neue Therapiestrategien zu entwickeln. In dieser Studie habe ich 1. den Typ I Interferon (IFN)-stimulierenden Signalweg des angeborenen Immunsystems in Pneumokokken-infizierten Wirtszellen sowie 2. dessen Bedeutung in der Pneumokokkenpneumonie untersucht. Humane und murine Makrophagen, aber nicht alveolare Epithelzellen, produzierten Typ I IFNs nach Infektion mit S. pneumoniae. Dieses war abhängig vom Virulenzfaktor Pneumolysin und e
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3

Bracht, Dagmar. "Proteomanalyse von Streptococcus pneumoniae." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=977729931.

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4

McNamee, Lynnelle Ann. "Effects of a primary influenza infection on susceptibility to a secondary Streptococcus pneumoniae infection." Diss., Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/mcnamee/McNameeL1206.pdf.

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5

Koo, Kun, and 古軍. "Vancomycin tolerance in streptococcus pneumoniae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970588.

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6

Wyres, Kelly L. "Genome evolution in Streptococcus pneumoniae." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:985b1fc6-c1a9-41b3-a20a-1735329d962b.

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Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen responsible for >1.6 million annual deaths globally. Pneumococcal penicillin-resistance is conferred by acquisition of ‘altered’ penicillin-binding protein (pbp) genes. The first penicillin-nonsusceptible pneumococci were identified in the late 1960s. Global pneumococcal penicillin-nonsusceptibility rates rapidly increased in the 1980s/90s. Since 2000, protein-conjugate vaccines, targeting 7, 10 or 13 of the ≥94 different pneumococcal capsule types (serotypes), have been introduced in many countries. Following vaccine implemen
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7

Rudmann, Emily. "Parsing the Streptococcus pneumoniae virulome." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108795.

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Thesis advisor: Tim van Opijnen<br>Streptococcus pneumoniae is a prominent gram-positive commensal and opportunistic pathogen which possesses a large pan-genome. Significant strain-to-strain variability in genomic content drives the use of varied pathways to perform similar processes between strains. Considering this variation, we employ a set of 36 strains, representative of 78% of total pan-genome diversity, with which to perform functional studies. We previously determined the set of genes required by 22 of the 36 strains to maintain successful infection in a host, or the virulome. In this
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8

Koo, Kun. "Vancomycin tolerance in streptococcus pneumoniae." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25139216.

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9

Alghofaili, Fayez Abdullah. "Streptococcus pneumoniae-stress hormone interactions." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/41267.

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Streptococcus pneumoniae is one of the most important bacterial pathogens of humans causing a wide range of mild to life-threating diseases. It is also a commensal microorganism in the nasopharynx of up to 60% of people. Fundamental aspects of its ability for transition from colonisation to an infectious state as well as how bacterial-host interactions influence this process are largely unknown. In the field of microbial endocrinology, it has been well established in mainly Gram-negative bacteria that stress hormones such as norepinephrine epinephrine and dopamine play an essential role in det
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10

Abdeldaim, Guma M. K. "PCR detection of Streptococcus pneumoniae and Haemophilus influenzae in pneumonia patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107931.

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11

Silva, Júnior Jailton de Azevedo. "Estudo da colonização nasofaringeana por Streptococcus pneumoniae em crianças com suspeita clínica de pneumonia." reponame:Repositório Institucional da FIOCRUZ, 2011. https://www.arca.fiocruz.br/handle/icict/4220.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-07-19T21:35:50Z No. of bitstreams: 1 Jailton de Azevedo Silva Junior Estudo da colonização....pdf: 1101716 bytes, checksum: 049972199c76bb97406fc006c2ba9c27 (MD5)<br>Made available in DSpace on 2012-07-19T21:35:50Z (GMT). No. of bitstreams: 1 Jailton de Azevedo Silva Junior Estudo da colonização....pdf: 1101716 bytes, checksum: 049972199c76bb97406fc006c2ba9c27 (MD5) Previous issue date: 2011<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Streptococcus pneumoniae constitui um
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12

Scholtz, Janet. "The serotypes and antimicrobial susceptibility patterns of streptococcus pneumoniae in the Cape Peninsula." Thesis, Cape Technikon, 2000. http://hdl.handle.net/20.500.11838/1464.

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Thesis (Masters Diploma(Technology))--Cape Technikon, Cape Town, 2000<br>Streptococcus pneumoniae (S.pneumoniae) infections are an important cause of morbidity and mortality in adults and children worldwide. Mortality rates are highest amongst the very young and the elderly. Streptococcus pneumoniae is the most common form of community acquired bacterial pneumonia. Other diseases commonly caused by Streptococcus pneumoniae include meningitis, pericarditis, bacteraemia and septicaemia. Penicillin is today still consid3red the drug of choice when treating pneumococcal infections. The
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13

Machado, Lais Del Prá Netto. "Pneumonia bacteriana adquirida na comunidade: avaliação clínico-epidemiológica e padronização de métodos moleculares para detecção de Mycoplasma pneumoniae, Haemophilus influenzae e Streptococcus pneumoniae." reponame:Repositório Institucional da UFSC, 2015. https://repositorio.ufsc.br/xmlui/handle/123456789/158899.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.<br>Made available in DSpace on 2016-02-09T03:17:04Z (GMT). No. of bitstreams: 1 336847.pdf: 2261623 bytes, checksum: 5220583fc8a657b02f17b72e42ab63bc (MD5) Previous issue date: 2015<br>A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo poucos e frágeis estudos clínicos e epidemiológicos sobre pneumonias adquiridas na comunidade (PACs). Os patógenos mais frequentes nas PACs são Streptococcus
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14

Pratt, Stephanie Ann. "Immunoglobulin A1 protease of Streptococcus pneumoniae." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35410.

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The aim of this project was to examine the Streptococcal IgA1 proteases, with particular interest on the Streptococcus pneumoniae enzyme. IgA1 protease of S. pneumoniae was identified and characterised. A non-reducing polyacrylamide gel system was employed to screen clinical isolates for IgA1 protease activity. Of 187 isolates tested 18% were found to be IgA1 protease negative, there was no correlation with the site of isolation of the organism and its ability to produce the enzyme. Attempts were made to clone the pneumococcal IgA1 protease gene using the cosmid pEMBLcos4, the plasmid vector p
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15

Ho, Pak-leung, and 何柏良. "Emerging antimicrobial resistance in Streptococcus pneumoniae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290999.

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16

Ibrahim, Yasser Musa. "Stress response proteins in Streptococcus pneumoniae." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412962.

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17

Ouennane, Siham. "Interactions phage-hôte chez Streptococcus pneumoniae." Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27790.

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Streptococcus pneumoniae est une bactérie à la fois commensale et pathogène opportuniste chez l’humain. Elle est responsable de nombreuses infections telles que la pneumonie, la méningite, l’otite moyenne et la sinusite. En maladie infectieuse, S. pneumoniae occupe une place importante en tant que l’une des principales causes de morbidité et de mortalité dans le monde. Elle est dotée de plusieurs capacités fascinantes, comme la compétence naturelle pour l’aider à résister aux antibiotiques et la grande diversité des sérotypes capsulaires pour contourner la vaccination. Puisque la résistance au
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18

Carvalho, Ricardo Jorge da Silva. "Revisiting molecular diagnostics of Streptococcus pneumoniae." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16115.

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Mestrado em Biologia Molecular e Celular<br>Streptococcus pneumoniae is a human pathobiont that colonizes the nasopharynx. S. pneumoniae is responsible for causing non-invasive and invasive disease such as otitis, pneumonia, meningitis, and sepsis, being a leading cause of infectious diseases worldwide. Due to similarities with closely related species sharing the same niche, it may be a challenge to correctly distinguish S. pneumoniae from its relatives when using only non-culture based methods such as real time PCR (qPCR). In 2007, a molecular method targeting the major autolysin (lytA) of S.
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19

Chewapreecha, Kamolchanok. "Evolution of Streptococcus pneumoniae during carriage." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708595.

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20

Ho, Pak-leung. "Emerging antimicrobial resistance in Streptococcus pneumoniae." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290999.

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21

Burman, Lars Å. "Streptococcus pneumoniae : epidemiological, clinical and serological studies." Doctoral thesis, Umeå universitet, Infektionssjukdomar, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102563.

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A retrospective study of invasive pneumococcal disease in patients from Greater Göteborg in 1964- 1980 identified 125 cases of meningitis, 305 of pneumonia, 61 of septicemia with unknown focus, and 17 with other manifestations, all verified by cultures from normally sterile body fluids. The incidence was several times higher in infants and in the elderly than in any other age-group. A wide variety of underlying conditions were present in 23% of the infants, 34% of the children, and 81% of the adults. In adults alcoholism was known in one third of the cases. The case fatality rate was 24% among
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22

Ekdahl, Karl. "Immunological aspects on pneumococcal infections with special reference to bacteremic pneumococcal infections and recurrent pneumonia /." Lund : Dept. of Infectious Diseases, University of Lund, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39177549.html.

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23

Morona, Judy Kay. "Characterisation of the capsular polysaccharide biosynthesis loci of streptococcus pneumoniae serogroup 19 /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phm8678.pdf.

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24

CARRARO, MONICA. "Identification of infection biomarkers in a murine model of pneumonia by Streptococcus pneumoniae." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1037742.

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Streptococcus pneumoniae infections remain a public health problem despite the availability of vaccines. In order to study alternative preventive strategies it is essential to have a reliable animal model of the infection. To date, the majority of vaccine efficacy evaluation studies still rely on direct read-outs such as the survival rate after challenge and the CFU counts in blood and in the lungs. A murine model of lung infection was developed in which animal death was not the endpoint: clinical parameters, cellular lung infiltrate and systemic immune response were evaluated in (i) infected
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25

Gingles, Neill. "Murine mechanisms of resistance to Streptococcus pneumoniae." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29811.

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The aim of this thesis was to investigate the basis of genetic resistance or susceptibility to infection with S. pneumoniae using a mouse model of bronchopneumonia. To this end, a panel of strains of inbred mice was intranasally infected with S. pneumoniae type 2 strain (D39), and type 3 (GB05). BALB/c mice were resistant and CBA/Ca were susceptible to infection, particularly with D39 pneumococci. To analyse the genetic inheritance, filial generations (F1 mice and F2 mice) were produced from intercross breeding these two strains and subsequently challenged with D39 pneumococci. Further investi
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26

Gillespie, S. H. "Species specific diagnosis of Streptococcus pneumoniae infection." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261768.

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27

Yang, Yiping. "Characterisation of extracellular proteases of Streptococcus pneumoniae." Thesis, University of Sunderland, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402832.

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28

Ali, Farzana. "Streptococcus pneumoniae induced monocyte-derived-macrophage apoptosis." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397500.

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29

Perry, Frances. "Oxidative responses of neutrophils to Streptococcus pneumoniae." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335509.

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30

Cohen, J. M. "Colonisation-induced protection against Streptococcus pneumoniae disease." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1124359/.

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Streptococus pneumoniae is an important human pathogen, yet in most individuals it establishes only transient nasopharyngeal colonisation without causing disease. Using murine models, this thesis explores the hypothesis that colonisation induces acquired immune responses which protect against subsequent pneumonia. Colonisation models with wild-type (WT) and mutant S. pneumoniae were established in outbred CD1 mice. Mutants lacked either capsule or lipoproteins, or were auxotrophs unable to replicate in vivo. WT colonisation protected against subsequent pneumonia. Mutants were cleared more rapi
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31

Abrahams, Katherine Anne. "The enzymology of Streptococcus pneumoniae peptidoglycan polymerisation." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/53797/.

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Bacterial cell survival depends on intact peptidoglycan, an extensive cell wall polymer of alternating N-acetylglucosamine and N-acetylmuramic acid residues, cross-linked by short peptides. Peptidoglycan biosynthesis is a viable and validated antimicrobial target; the intracellular, membrane-bound and extracellular synthetic stages provide a multitude of enzymes for interception with inhibitors. The ultimate phase of peptidoglycan biosynthesis occurs on the extracellular face of the cytoplasmic membrane and involves the polymerisation of Lipid II (the monomeric peptidoglycan precursor) by the
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32

Herbert, Jenny. "Genetic regulation of virulence in Streptococcus pneumoniae." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4204/.

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S.pneumoniae is the leading cause of bacterial pneumonia and meningitis. Pneumonia alone has been estimated to kill more children under the age of five than that caused by AIDS, malaria and tuberculosis combined. The current vaccines which are used to prevent pneumococcal infection only protect against a small number of the 90+ serotypes currently identified. Current issues which may prevent the long term use of these vaccines is capsular switching, a phenomenon observed where some strains are able to escape the vaccine through switching their capsule genes. Further serotype replacement has be
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33

Noori, Muhammad Yahya. "Genetic variation and virulence of Streptococcus pneumoniae." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4440/.

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Streptococcus pneumoniae or pneumococcus is included among major human pathogens and is responsible for a number of diseases including life-threatening conditions such as pneumonia, meningitis and sepsis. Though pneumococcal vaccines are available, they provide limited coverage against infections as pneumococcus shows extensive variation, which also allows escape from vaccines and antibiotic resistance. It is armed with several virulence factors including capsule, surface proteins, enzymes and toxins, which are variably expressed and altogether determine pneumococcal virulence. The aim of this
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34

Pavao, Aiden. "Modeling the metabolic diversity of Streptococcus pneumoniae." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:109024.

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Thesis advisor: Tim van Opijnen<br>Each year, the opportunistic pathogen Streptococcus pneumoniae causes millions of illnesses and nearly 300,000 deaths worldwide. Despite widespread vaccination campaigns, S. pneumoniae persists as a public health risk in large part to its high genomic diversity. In previous work, our group has shown that functional pathways, including stress response to antibiotics, are not necessarily conserved between pneumococcal strains. Thus, a holistic pangenome view of S. pneumoniae is a promising avenue to gain understanding of the species and to inform clinical treat
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35

Malak, H. "Pneumolysin-macrophage interactions in Streptococcus pneumoniae infection." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001781/.

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36

Alsharif, Sultan M. M. "Stress response and pathogenicity in Streptococcus pneumoniae." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5231/.

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The pathogen Streptococcus pneumoniae encounters different levels of oxygen during the infection cycle including colonisation, pneumonia, bateraemia and meningitis. These different anatomical niches require high levels of genome changes to sense and respond to those external environmental stimuli. The bacterial gene expression is known to be affected by oxygen, and it must react properly for survival and for developing invasive pneumococcal desiseases (IPDs). Microarray techniques have allowed scanning the whole pneumococcal genome during growth in different tensions of oxygen mimicking in viv
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37

Inverarity, Donald James. "Genomic diversity in naturally transformable Streptococcus pneumoniae." Thesis, Connect to e-thesis, 2009. http://theses.gla.ac.uk/901/.

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Thesis (Ph.D.) - University of Glasgow, 2009.<br>Ph.D. thesis submitted to Faculty of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, 2009. Includes bibliographical references. Print version also available.
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38

Østergaard, Andersen Christian. "Streptococcus pneumoniae meningitis : clinical and experimental studies /." KøbenhavnLægeforeningens Forlag : Lægeforeningens Forlag, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015627763&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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39

Coffey, Tracey Jean. "Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae." Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357230.

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40

Halle, Annett. "Streptococcus pneumoniae induziert Apoptose in zerebralen Endothelzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15193.

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Die bakterielle Meningitis ist trotz der Anwendung modernster Antibiotika mit einer hohen Letalität und neurologischen Spätkomplikationen verbunden. Ein entscheidendes Ereignis ist dabei der Zusammenbruch der Blut-Hirn-Schranke (BHS). Die genauen Mechanismen, die zu ihrer Schädigung führen, sind bis heute unklar. In dieser Arbeit wurde untersucht, ob lebende Pneumokokken in einem Zellkulturmodell der BHS zu einer apoptotischen Zellschädigung von zerebralen Endothelzellen, als wichtigstem zellulären Bestandteil der BHS, führen und damit zu ihrer strukturellen Schädigung beitragen. Mittels versc
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41

Lock, Robert Arthur. "Studies on virulence proteins of Streptococcus Pneumoniae /." Title page, summary and table of contents only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phl813.pdf.

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42

Leite, Ilaiáli Souza. "Inativação de Streptococcus pneumoniae por terapia fotodinâmica infravermelha com indocianina verde e sua interação com macrófagos RAW 264.7." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-17092015-110348/.

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As infecções do trato respiratório inferior lideram entre as principais causas de morbidade e mortalidade no mundo. Um dos grandes problemas associados ao tratamento das infecções do sistema respiratório, como as pneumonias, advém da crescente resistência aos mais modernos antibióticos adquirida pelos microrganismos. A terapia fotodinâmica, uma técnica baseada na interação da luz com uma substância fotoativa para causar dano oxidativo a células, tem se destacado como uma interessante alternativa para diversas doenças como diferentes tipos de câncer e infecções. Neste trabalho foi realizada, co
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43

Agarwal, Vaibhav. "Role of PspC interaction with human polymeric immunoglobulin receptor and Factor H in Streptococcus pneumoniae infections and host cell induced signalling." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3652/.

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44

Lores, Lazara Elena Santiesteban. "Síntese, caracterização e avaliação imunológica de conjugados do sorotipo 6B de Streptococcus pneumoniae à proteína A de superfície pneumocócica (PspA)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-19062017-151232/.

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As vacinas conjugadas contra Streptococcus pneumoniae mostram-se eficazes na redução da doença pneumocócica, no entanto depois de sua introdução tem se verificado a substituição de sorotipos. Para evitar estes problemas o emprego de proteínas da própria bactéria como carreadoras tem sido usado. Neste trabalho a PspA foi conjugada ao sorotipo 6B de S. pneumoniae por dois métodos de conjugação. Inicialmente a PspA clado 1 e 3 foram purificadas, recuperando as proteínas com mais de 90% de pureza. A conjugação intermediada pelo agente ativador cloreto de 4-(4,6-dimetoxi-1,3,5-triazin-2-il-)-4-meti
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45

Piroth, Lionel. "Apports d'un modèle de pneumonie expérimentale bactériémique à streptococcus pneumoniae de sensibilité diminuée à la pénicilline dans la prise en charge des pneumonies humaines." Dijon, 2001. http://www.theses.fr/2001DIJOMU02.

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Strpetococcus pneumoniae est l'un des pathogenes les plus frequemment responsables de pneumonies bacteriemiques, avec une morbidite et une mortalite consequentes. L'incidence des souches de s. Pneumoniae de sensibilite diminuee a la penicilline et a d'autres antibiotiques est en constante augmentation. Ces donnees et les problemes therapeutiques inherents soulignent l'importance d'une meilleure connaissance des relations hote-pathogene-antibiotique, que seuls les modeles experimentaux permettent d'approfondir significativement. Nous avons pu developper un modele reproductible et simple de pneu
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Bennett, Allison E. "Characterization of sortase and its effect on the virulence of Streptococcus pneumoniae." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/bennet.pdf.

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47

Bui, Nhat Khai. "Characterisation of cell wall enzymes from Streptococcus pneumoniae." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556139.

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Murein and its turnover products are recognised by components of the innate immune system leading to an inflammatory response and resulting in the killing of bacteria. To counter the clearance by the innate immune system pathogens like Streptococcus pneumoniae have enzymes to modify their cell wall so that they are no longer recognised. The most common modifications are the N-deacetylation and O-acetylation of the glycan strands in the murein. Deacetylated murein was shown to be a poor substrate for lysozyme which is an important factor of the innate immune system capable of lysing sensitive b
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Hemsley, Carolyn. "Investigation of virulence gene regulation in Streptococcus pneumoniae." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410462.

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Streptococcus pneumoniae is an important human pathogen in all age groups worldwide that causes a variety of diseases, ranging from life threatening septicaemia and meningitis to less severe sinusitis and otitis media. The factors that determine the virulence of S. pneumoniae are very complex but a key aspect of the organism's disease causing potential is the ability of the bacteria to regulate virulence factor expression and activity. In this study two main approaches were taken to investigate virulence gene expression in S. pneumoniae. Firstly, the feasibility of Recombinase based In vivo Ex
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Reid, Nicholas. "Clinical, microbiological and molecular epidemiology of Streptococcus pneumoniae." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311200.

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<I>Streptococcus pneumoniae</I> is a serious pathogen, responsible for a large proportion of cases of pneumonia, bacteraemia and meningitis. Restriction endonuclease analysis (REA) using <I>Taq </I>I and <I>Hae</I> III was evaluated to analyse the genetic relationships among 51 isolates of <I>S. pneumoniae</I> in four different serotypes. This method was used together with pulsed-field gel electrophoresis (PFGE) in the analysis of clinical isolates of bacteraemic <I>S. pneumoniae</I> in the Grampian region of Scotland during a two year period from 1993-5. A total of 104 isolates were collected
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Campbell, James. "Utilisation of glycoprotein-derived carbohydrates by streptococcus pneumoniae." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410339.

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