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Journal articles on the topic 'Streptococcus (S.) suis, pathogens, pigs'

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Published: 4 June 2021
Last updated: 3 February 2022

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1

Zheng, P., Y. X. Zhao, A. D. Zhang, C. Kang, H. C. Chen, and M. L. Jin. "Pathologic Analysis of the Brain from Streptococcus suis Type 2 Experimentally Infected Pigs." Veterinary Pathology 46, no. 3 (2009): 531–35. http://dx.doi.org/10.1354/vp.08-vp-0043-j-fl.

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Streptococcus suis type 2 ( S. suis 2) is known as a major porcine pathogen worldwide and causes meningitis, septicemia, endocarditis, arthritis, and septic shock in pigs. Suilysin, a secreted protein of S. suis 2, is considered to be an important S. suis 2 virulence-associated factor. In this paper, the cerebellar lesions following experimental infection of pigs with S. suis 2 were studied. An immunohistochemical technique was applied to compare the distribution of bacteria and secreted suilysin protein in brain. The infected pigs developed histologic lesions of meningoencephalitis. Immunohis
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2

Segura, Mariela. "Streptococcus suis Research: Progress and Challenges." Pathogens 9, no. 9 (2020): 707. http://dx.doi.org/10.3390/pathogens9090707.

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Streptococcus suis is considered among the top bacterial pathogens leading to important economic losses to the swine industry, with the incidence of disease increasing as the prophylactic use of antimicrobial is being vanished worldwide. S. suis is also a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Besides, in some Asian countries, it is considered a major public health concern for the general population as well. Antimicrobial resistance is one of the most important global health challenges, and in the absence of preventive measures (such as effective vac
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3

Meurer, Marita, Sophie Öhlmann, Marta C. Bonilla, et al. "Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis." International Journal of Molecular Sciences 21, no. 15 (2020): 5289. http://dx.doi.org/10.3390/ijms21155289.

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Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against S. suis infections, release neutrophil extracellular traps (NETs) to entrap pathogens. In this study, we investigated the role of the secreted nuclease A of S. suis (SsnA) as a NET-evasion factor in vivo and in vitro. Piglets were intranasally infected with S. suis strain 10 or an isogenic ssnA mutant. DNase and NET-formation were analyzed in cerebrospinal fluid (CSF) and brain tissue. Animals infected with S. suis strain 10 or S. suis 10ΔssnA showed the presence of N
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4

Boye, Mette, Anne A. Feenstra, Conny Tegtmeier, Lars Ole Andresen, Søren R. Rasmussen, and Vivi Bille-Hansen. "Detection of Streptococcus Suis by in Situ Hybridization, Indirect Immunofluorescence, and Peroxidase-Antiperoxidase Assays in Formalin-Fixed, Paraffin-Embedded Tissue Sections from Pigs." Journal of Veterinary Diagnostic Investigation 12, no. 3 (2000): 224–32. http://dx.doi.org/10.1177/104063870001200305.

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Streptococcus suis is an important pathogen in pigs and is considered a zoonotic agent. To aid diagnosis of infection caused by S. suis, a species-specific probe targeting 16S ribosomal RNA was designed and used for fluorescent in situ hybridization. Two additional immunohistochemical detection methods, an indirect immunofluorescence assay and a peroxidase-antiperoxidase method, using polyclonal antibodies also were developed. The specificity of the oligonucleotide probe was examined by whole-cell and dot-blot hybridization against reference strains of the 35 serotypes of S. suis and other clo
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5

Kerdsin, Anusak, Dan Takeuchi, Aniroot Nuangmek, Yukihiro Akeda, Marcelo Gottschalk, and Kazunori Oishi. "Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand." Pathogens 9, no. 1 (2020): 50. http://dx.doi.org/10.3390/pathogens9010050.

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Streptococcus suis is a zoonotic pathogen of economic significance to the swine industry. The number of infected cases is increasing in humans worldwide. In this study, we determined the prevalence and diversity of S. suis carriage in slaughterhouse pigs in Phayao province, Thailand, where an outbreak occurred in 2007. The overall S. suis carriage rate was 35.2% among slaughterhouse pigs. The prevalence rates of serotypes 2 and 14 (the major serotypes infected in humans) were 6.7% and 2.6%, respectively. In both serotypes, 70.4% of isolates of serotypes 2 and 14 revealed sequence types and pul
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6

Chaiden, Chadaporn, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sittiruk Roytrakul, Anusak Kerdsin, and Suphachai Nuanualsuwan. "Peptidomics Analysis of Virulent Peptides Involved in Streptococcus suis Pathogenesis." Animals 11, no. 9 (2021): 2480. http://dx.doi.org/10.3390/ani11092480.

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Streptococcus suis (S. suis) is a zoonotic pathogen causing severe streptococcal disease worldwide. S. suis infections in pigs and humans are frequently associated with the virulent S. suis serotype 2 (SS2). Though various virulence factors of S. suis have been proposed, most of them were not essentially accounted for in the experimental infections. In the present study, we compared the peptidomes of highly virulent SS2 and SS14 in humans, the swine causative serotypes SS7 and SS9, and the rarely reported serotypes SS25 and SS27, and they were cultured in a specified culture medium containing
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7

Hennig-Pauka, Isabel, Rabea Imker, Leonie Mayer, et al. "From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis." Pathogens 8, no. 4 (2019): 249. http://dx.doi.org/10.3390/pathogens8040249.

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Swine stocks are endemically infected with the major porcine pathogen Streptococcus (S.) suis. The factors governing the transition from colonizing S. suis residing in the tonsils and the exacerbation of disease have not yet been elucidated. We analyzed the sudden death of fattening pigs kept under extensive husbandry conditions in a zoo. The animals died suddenly of septic shock and showed disseminated intravascular coagulopathy. Genotypic and phenotypic characterizations of the isolated S. suis strains, a tonsillar isolate and an invasive cps type 2 strain, were conducted. Isolated S. suis f
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8

Gajdács, Márió, Anita Németh, Márta Knausz, et al. "Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?" Microorganisms 8, no. 9 (2020): 1292. http://dx.doi.org/10.3390/microorganisms8091292.

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Streptococcus suis (S. suis) is an emerging zoonotic pathogen, demonstrated as an etiological agent in human infections in increasing frequency, including diseases like purulent meningitis, sepsis, uveitis-endophtalmitis and arthritis. Due to the increased availability and utility of novel diagnostic technologies in clinical microbiology, more studies have been published on the epidemiology of S. suis, both in veterinary and human medicine; however, there are no comprehensive data available regarding human S. suis infections from East-Central European countries. As a part of our study, data we
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9

Jacques, Mario, Marcelo Gottschalk, Bernadette Foiry, and Robert Higgins. "Ultrastructural study on surface components of Streptococcus suis." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 598–99. http://dx.doi.org/10.1017/s0424820100160546.

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Streptococcus suis is an important pathogen in pigs. To the best of our knowledge, surface components of S. suis have not been studied. As part of our work dealing with the characterization of S. suis virulence factors, we examined the surface components of nine reference strains. Bacterial capsules are composed of highly hydrated polymers, usually polysaccharides. Because of their chemical properties, they can collapse during dehydration prior to electron microscopy. Jacques and Graham have recently introduced a modified aldehyde fixation process in which addition of a primary amine was found
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10

Li, Yuanyi, Gabriela Martinez, Marcelo Gottschalk, et al. "Identification of a Surface Protein of Streptococcus suis and Evaluation of Its Immunogenic and Protective Capacity in Pigs." Infection and Immunity 74, no. 1 (2006): 305–12. http://dx.doi.org/10.1128/iai.74.1.305-312.2006.

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ABSTRACT A Streptococcus suis surface protein reacting with convalescent-phase sera from pigs clinically infected by S. suis type 2 was identified. The apparent 110-kDa protein, designated Sao, exhibits typical features of membrane-anchored surface proteins of gram-positive bacteria, such as a signal sequence and an LPVTG membrane anchor motif. In spite of high identity with the partially sequenced genomes of S. suis Canadian strain 89/1591 and European strain P1/7, Sao does not share significant homology with other known sequences. However, a conserved avirulence domain that is often found in
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11

Wang, Zhaofei, Jingjiao Ma, Jian Wang, et al. "Application of the Phage Lysin Ply5218 in the Treatment of Streptococcus suis Infection in Piglets." Viruses 11, no. 8 (2019): 715. http://dx.doi.org/10.3390/v11080715.

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Streptococcus suis (S. suis) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against S. suis infections are urgently needed. In the previous study, a cell wall hydrolase or lysin derived from Streptococcus prophage phi5218, termed Ply5218, was identified. This lysin showed strong bacteriolytic activity against S. suis. In the current study, the in vitro data showed that after incubation with pig serum, the bacteriolytic efficacy of Ply5218 declined in
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12

Segura, Mariela, Virginia Aragon, Susan Brockmeier, et al. "Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis." Pathogens 9, no. 5 (2020): 374. http://dx.doi.org/10.3390/pathogens9050374.

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Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks emerged in Asia, making this bacterium a primary health concern in this part of the globe. In pigs, S. suis disease results in decreased performance and increased mortality, which have a significant economic impact on swine production worldwide. Facing the new regulations in preventive use of antimicrobials in livestock and lack of effective vaccines, control of S. suis inf
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13

Zhao, Yan, Gang Li, Xin-Yue Yao, et al. "The Impact of SsPI-1 Deletion on Streptococcus suis Virulence." Pathogens 8, no. 4 (2019): 287. http://dx.doi.org/10.3390/pathogens8040287.

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(1) Background: Streptococcus suis is an important zoonotic pathogen that infects pigs and can occasionally cause life-threatening systemic infections in humans. Two large-scale outbreaks of streptococcal toxic shock-like syndrome in China suggest that the pathogenicity of S. suis has been changing in recent years. Genetic analysis revealed the presence of a chromosomal pathogenicity island (PAI) designated SsPI-1 in Chinese epidemic S. suis strains. The purpose of this study is to define the role of SsPI-1 in the virulence of S. suis. (2) Methods: A SsPI-1 deletion mutant was compared to the
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14

Mi, Kun, Mei Li, Lei Sun, et al. "Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs." Antibiotics 10, no. 8 (2021): 958. http://dx.doi.org/10.3390/antibiotics10080958.

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Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative and gram-positive bacteria. The aim of this study was to derive an optimal dosage of cefquinome against S. suis with a pharmacokinetic/pharmacodynamic (PK/PD) integration model in the target infection site and to investigate the cutoffs monitoring the changes of resistance. The minimum inhibitory concentration (MIC) distribution of cefquinome against 342 S. suis strains was determined. MIC50 and MIC90 were 0.06 an
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15

Songsungthong, Warangkhana, Sunisa Prasopporn, Louise Bohan, Potjanee Srimanote, Ubolsree Leartsakulpanich, and Suganya Yongkiettrakul. "A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase." PeerJ 9 (February 3, 2021): e10743. http://dx.doi.org/10.7717/peerj.10743.

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Streptococcus suis is a Gram-positive bacterial pathogen of pigs and an emerging zoonotic pathogen. It has become increasingly resistant to multiple classes of antibiotics. New drug candidates and knowledge of their targets are needed to combat antibiotic-resistant S. suis. In this study, the open-source Pathogen Box compound library was screened. Thirty hits that effectively inhibited S. suis growth at 10 µM were identified. Among the most potent hits, MMV675968 (a diaminoquinazoline analog) was shown to target S. suis dihydrofolate reductase (SsDHFR) via (1) growth inhibition of an E. coli s
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16

Renzhammer, René, Igor Loncaric, Marisa Ladstätter, et al. "Detection of Various Streptococcus spp. and Their Antimicrobial Resistance Patterns in Clinical Specimens from Austrian Swine Stocks." Antibiotics 9, no. 12 (2020): 893. http://dx.doi.org/10.3390/antibiotics9120893.

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Knowledge of pathogenic potential, frequency and antimicrobial resistance patterns of porcine Streptococcus (S.) spp. other than S. suis is scarce. Between 2016 and 2020, altogether 553 S. spp. isolates were recovered from clinical specimens taken from Austrian swine stocks and submitted for routine microbiological examination. Antimicrobial susceptibility testing towards eight antimicrobial substances was performed using disk diffusion test. All isolates from skin lesions belonged to the species S. dysgalactiae subspecies equisimilis (SDSE). S. hyovaginalis was mainly isolated from the upper
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17

HUONG, V. T. L., L. V. THANH, V. D. PHU, et al. "Temporal and spatial association of Streptococcus suis infection in humans and porcine reproductive and respiratory syndrome outbreaks in pigs in northern Vietnam." Epidemiology and Infection 144, no. 1 (2015): 35–44. http://dx.doi.org/10.1017/s0950268815000990.

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SUMMARYPorcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including Streptococcus suis – an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human S. suis infection and PRRS outbreaks in pigs in northern Vietnam. We included 90 S. suis case-patients and 183 non-S. suis sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data f
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Wang, Shujie, Defu Zhang, Chenggang Jiang, et al. "Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia." Pathogens 10, no. 2 (2021): 213. http://dx.doi.org/10.3390/pathogens10020213.

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Streptococcus suis causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of a multidrug-resistant S. suis serotype 28 (strain 11313) and a multidrug-resistant S. suis serotype 31 (strain 11LB5). Strain 11313 was apathogenic in mouse infection models, whereas strain 11LB5 displayed ganglion demyelination, meningeal thickening, congestion, mononuclear cell infiltration, massive proliferation of cortical glial cells, and
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19

Willenborg, J., M. Fulde, A. de Greeff, et al. "Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis." Microbiology 157, no. 6 (2011): 1823–33. http://dx.doi.org/10.1099/mic.0.046417-0.

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Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia. Since the host environment seems to be an important regulatory component for virulence, we related expression of virulence determinants of S. suis to glucose availability during growth and to the sugar metabolism regulator catabolite control protein A (CcpA). We found that expression of the virulence-associated genes arcB, representing arcABC operon expression, cps
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Lacouture, Sonia, Masatoshi Okura, Daisuke Takamatsu, Lorelei Corsaut, and Marcelo Gottschalk. "Development of a mismatch amplification mutation assay to correctly serotype isolates of Streptococcus suis serotypes 1, 2, 1/2, and 14." Journal of Veterinary Diagnostic Investigation 32, no. 3 (2020): 490–94. http://dx.doi.org/10.1177/1040638720915869.

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Streptococcus suis is one of the most important bacterial swine pathogens worldwide and is an emerging pathogen in humans. There are 29 serotypes, and serotyping, which is based on the antigenicity of the capsular polysaccharide (CPS) or on its coding genes, is often part of routine identification and provides further information regarding S. suis virulence and zoonotic potential. Serotypes 2 and 14 possess high zoonotic potential, and serotype 1/2 is the serotype most frequently isolated from diseased pigs in North America. PCR has replaced antibody-based techniques to perform serotyping. How
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21

Giang, Elissa, Benjamin M. Hetman, Jan M. Sargeant, Zvonimir Poljak, and Amy L. Greer. "Examining the Effect of Host Recruitment Rates on the Transmission of Streptococcus suis in Nursery Swine Populations." Pathogens 9, no. 3 (2020): 174. http://dx.doi.org/10.3390/pathogens9030174.

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Streptococcus suis is a swine pathogen that is capable of causing severe outbreaks of disease in the nursery. Demographic parameters such as host recruitment rates can have profound effects on the transmission dynamics of infectious diseases and, thus, are critically important in high-turnover populations such as farmed swine. However, knowledge concerning the implications that such parameters have on S. suis disease control remains unknown. A stochastic mathematical model incorporating sub-clinically infected pigs was developed to capture the effects of changes in host recruitment rate on dis
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Harel, J., G. Martinez, A. Nassar, et al. "Identification of an Inducible Bacteriophage in a Virulent Strain of Streptococcus suis Serotype 2." Infection and Immunity 71, no. 10 (2003): 6104–8. http://dx.doi.org/10.1128/iai.71.10.6104-6108.2003.

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ABSTRACT Streptococcus suis infection is considered to be a major problem in the swine industry worldwide. Most virulent Canadian isolates of S. suis serotype 2 do not produce the known virulence markers for this pathogen. PCR-based subtraction hybridization was adapted to isolate unique DNA sequences which were specific to virulent strains of S. suis isolated in Canada. Analysis of some subtracted DNA clones revealed significant homology with bacteriophages of gram-positive bacteria. An inducible phage (named Ss1) was observed in S. suis following the incubation of the virulent strain 89-999
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Wongsawan, Kanruethai, Wasana Chaisri, Sahatchai Tangtrongsup, and Raktham Mektrirat. "Bactericidal Effect of Clove Oil against Multidrug-Resistant Streptococcus suis Isolated from Human Patients and Slaughtered Pigs." Pathogens 9, no. 1 (2019): 14. http://dx.doi.org/10.3390/pathogens9010014.

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Streptococcus suis is a zoonotic pathogen that is currently considered an emerging multidrug-resistant (MDR). Increasing antibiotic resistance can lead to the unsuccessful treatment of S. suis infection. Recently, many investigations of medicinal plants were conducted for the treatment of infection as a result of the increase of antibiotic-resistant bacteria. The aims of this study were to determine the chemical composition of essential oil from Syzygium aromaticum (L.) Merr. & L.M. Perry and the antibacterial activities of clove oil on MDR S. suis. Using gas chromatography coupled to a ma
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Mélançon, D., and D. Grenier. "Production and Properties of Bacteriocin-Like Inhibitory Substances from the Swine Pathogen Streptococcus suis Serotype 2." Applied and Environmental Microbiology 69, no. 8 (2003): 4482–88. http://dx.doi.org/10.1128/aem.69.8.4482-4488.2003.

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ABSTRACT Streptococcus suis serotype 2 is a major pathogen found in the upper respiratory tract of swine. In this study, isolates of this bacterial species were tested for the production of bacteriocin-like inhibitory substances (BLIS). Of the 38 strains tested, four inhibited the growth of other S. suis isolates according to a deferred-antagonism plate assay. Interestingly, three of the strains were originally isolated from healthy carrier pigs and were considered nonvirulent. Three isolates (94-623, 90-1330, and AAH4) that produced BLIS in liquid broth were selected for further characterizat
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Pan, Xiuzhen, Junchao Ge, Ming Li, et al. "The Orphan Response Regulator CovR: a Globally Negative Modulator of Virulence in Streptococcus suis Serotype 2." Journal of Bacteriology 191, no. 8 (2009): 2601–12. http://dx.doi.org/10.1128/jb.01309-08.

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ABSTRACT Streptococcus suis serotype 2 is an emerging zoonotic pathogen responsible for a wide range of life-threatening diseases in pigs and humans. However, the pathogenesis of S. suis serotype 2 infection is not well understood. In this study, we report that an orphan response regulator, CovR, globally regulates gene expression and negatively controls the virulence of S. suis 05ZYH33, a streptococcal toxic shock syndrome (STSS)-causing strain. A covR-defective (ΔcovR) mutant of 05ZYH33 displayed dramatic phenotypic changes, such as formation of longer chains, production of thicker capsules,
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Goyette-Desjardins, Guillaume, Cynthia Calzas, Tze Chieh Shiao, et al. "Protection against Streptococcus suis Serotype 2 Infection Using a Capsular Polysaccharide Glycoconjugate Vaccine." Infection and Immunity 84, no. 7 (2016): 2059–75. http://dx.doi.org/10.1128/iai.00139-16.

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Streptococcus suisserotype 2 is an encapsulated bacterium and one of the most important bacterial pathogens in the porcine industry. Despite decades of research for an efficient vaccine, none is currently available. Based on the success achieved with other encapsulated pathogens, a glycoconjugate vaccine strategy was selected to elicit opsonizing anti-capsular polysaccharide (anti-CPS) IgG antibodies. In this work, glycoconjugate prototypes were prepared by couplingS. suistype 2 CPS to tetanus toxoid, and the immunological features of the postconjugation preparations were evaluatedin vivo. In
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Bamphensin, Nichari, Peechanika Chopjitt, Rujirat Hatrongjit, et al. "Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans." Pathogens 10, no. 9 (2021): 1178. http://dx.doi.org/10.3390/pathogens10091178.

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Streptococcus suis is a pathogen that causes invasive infections in humans and pigs. In this study, 448 S. suis isolates recovered from human infections in Thailand were characterized with regard to their antimicrobial susceptibility and antimicrobial resistance genes, including, for non-penicillin-susceptible isolates, sequence analyses of five genes encoding penicillin-binding proteins (pbp1a, pbp1b, pbp2a, pbp2b, and pbp2x). All 448 isolates were susceptible to cefepime and ceftriaxone, whereas 99.6%, 91.7%, and 72.9% of the isolates were susceptible to levofloxacin, penicillin, and chloram
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Dresen, Muriel, Josephine Schenk, Yenehiwot Berhanu Weldearegay, et al. "Streptococcus suis Induces Expression of Cyclooxygenase-2 in Porcine Lung Tissue." Microorganisms 9, no. 2 (2021): 366. http://dx.doi.org/10.3390/microorganisms9020366.

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Streptococcus suis is a common pathogen colonising the respiratory tract of pigs. It can cause meningitis, sepsis and pneumonia leading to economic losses in the pig industry worldwide. Cyclooxygenase-2 (COX-2) and its metabolites play an important regulatory role in different biological processes like inflammation modulation and immune activation. In this report we analysed the induction of COX-2 and the production of its metabolite prostaglandin E2 (PGE2) in a porcine precision-cut lung slice (PCLS) model. Using Western blot analysis, we found a time-dependent induction of COX-2 in the infec
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Aranda, Jesús, Maria Elena Garrido, Pilar Cortés, Montserrat Llagostera, and Jordi Barbé. "Analysis of the Protective Capacity of Three Streptococcus suis Proteins Induced under Divalent-Cation-Limited Conditions." Infection and Immunity 76, no. 4 (2008): 1590–98. http://dx.doi.org/10.1128/iai.00987-07.

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ABSTRACT Streptococcus suis is a gram-positive pathogen that causes serious diseases in pigs and, in some cases, humans. Three genes of the virulent S. suis 89/1591 strain, encoding putative divalent-cation-binding lipoproteins, were isolated based on information obtained from the draft annotation files of this organism's genome. The products of these genes, which are inducible by divalent-cation deprivation, were subsequently purified, and their immunogenic and protective abilities were analyzed. All three proteins (SsuiDRAFT 0103, SsuiDRAFT 0174, and SsuiDRAFT 1237) were found to be immunoge
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Vaillancourt, Katy, Laetitia Bonifait, Louis Grignon, Michel Frenette, Marcelo Gottschalk, and Daniel Grenier. "Identification and characterization of a new cell surface protein possessing factor H-binding activity in the swine pathogen and zoonotic agent Streptococcus suis." Journal of Medical Microbiology 62, no. 7 (2013): 1073–80. http://dx.doi.org/10.1099/jmm.0.057877-0.

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Streptococcus suis is a major swine pathogen and an emerging zoonotic agent. The ability of pathogenic bacteria to bind the complement regulator factor H on their cell surface may allow them to avoid complement attack and phagocytosis. The aim of this study was to characterize a new cell surface protein possessing factor H-binding activity in S. suis serotype 2. The capacity of S. suis to bind the complement regulator factor H on its surface was demonstrated by ELISA. Using a factor I–cofactor assay, it was found that the functional activity of factor H bound to S. suis was kept. Since the pro
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King, Samantha J., Andrew G. Allen, Duncan J. Maskell, Christopher G. Dowson, and Adrian M. Whatmore. "Distribution, Genetic Diversity, and Variable Expression of the Gene Encoding Hyaluronate Lyase within the Streptococcus suis Population." Journal of Bacteriology 186, no. 14 (2004): 4740–47. http://dx.doi.org/10.1128/jb.186.14.4740-4747.2004.

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ABSTRACT Although Streptococcus suis is an economically important pathogen of pigs and an occasional cause of zoonotic infections of humans knowledge of crucial virulence factors, and as a consequence targets for therapeutic or prophylactic intervention, remains limited. Here we describe a detailed study of the distribution, diversity, and in vitro expression of hyaluronate lyase, a protein implicated as a virulence factor of many mucosal pathogens. The gene encoding hyaluronate lyase, hyl, was present in all 309 bona fide S. suis isolates examined representing diverse serotypes, geographic so
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Chaiden, Chadaporn, Janthima Jaresitthikunchai, Anusak Kerdsin, Nattakan Meekhanon, Sittiruk Roytrakul, and Suphachai Nuanualsuwan. "Streptococcus suis serotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry." PLOS ONE 16, no. 5 (2021): e0249682. http://dx.doi.org/10.1371/journal.pone.0249682.

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Streptococcus suis, particularly S. suis serotype 2 (SS2), is an important zoonotic pathogen causing meningitis in humans worldwide. Although the proper classification of the causative and pathogenic serotype is salutary for the clinical diagnosis, cross-reactions leading to the indistinguishability of serotypes by the current serotyping methods are significant limitations. In the present study, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of extracted peptides was developed to improve the classification of serotype of S. suis. The peptid
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Ágoston, Zsuzsanna, Gabriella Terhes, Péter Hannauer, Márió Gajdács, and Edit Urbán. "Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature." Acta Microbiologica et Immunologica Hungarica 67, no. 3 (2020): 148–55. http://dx.doi.org/10.1556/030.2020.01123.

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AbstractStreptococcus suis is an emerging zoonotic human pathogen, which is a causative agent of invasive infections in people who are in close contact with infected pigs or contaminated pork products. It is associated with severe systemic infections, most commonly meningitis and sepsis, which may lead to high rates of morbidity and mortality. Serotype 2 is the most prevalent type in S. suis infections in humans. We have reported a case of a very rapidly proceeding fatal human S. suis infection in a splenectomized, but otherwise immunocompetent patient in Hungary. We would like to highlight th
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34

Fulde, Marcus, Joerg Willenborg, Astrid de Greeff, et al. "ArgR is an essential local transcriptional regulator of the arcABC operon in Streptococcus suis and is crucial for biological fitness in an acidic environment." Microbiology 157, no. 2 (2011): 572–82. http://dx.doi.org/10.1099/mic.0.043067-0.

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Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance, very little is known about the factors that contribute to its virulence. Recently, we identified a new putative virulence factor in S. suis, the arginine deiminase system (ADS), an arginine catabolic enzyme system encoded by the arcABC operon, which enables S. suis to survive in an acidic environment. In this study, we focused on ArgR, an ADS-associated regulator belonging to the ArgR/AhrC arginine repressor family. Using an argR knockout strain we w
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Lavagna, Agustina, Jean-Philippe Auger, Stephen E. Giradin, Nicolas Gisch, Mariela Segura та Marcelo Gottschalk. "Recognition of Lipoproteins by Toll-like Receptor 2 and DNA by the AIM2 Inflammasome Is Responsible for Production of Interleukin-1β by Virulent Suilysin-Negative Streptococcus suis Serotype 2". Pathogens 9, № 2 (2020): 147. http://dx.doi.org/10.3390/pathogens9020147.

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Streptococcus suis serotype 2 is an important porcine bacterial pathogen and zoonotic agent causing sudden death, septic shock and meningitis. These pathologies are the consequence of an exacerbated inflammatory response composed of various mediators including interleukin (IL)-1β. Elevated levels of the toxin suilysin (SLY) were demonstrated to play a key role in S. suis-induced IL-1β production. However, 95% of serotype 2 strains isolated from diseased pigs in North America, many of which are virulent, do not produce SLY. In this study, we demonstrated that SLY-negative S. suis induces elevat
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Matajira, Carlos E. C., Luisa Z. Moreno, Andre P. Poor, et al. "Streptococcus suis in Brazil: Genotypic, Virulence, and Resistance Profiling of Strains Isolated from Pigs between 2001 and 2016." Pathogens 9, no. 1 (2019): 31. http://dx.doi.org/10.3390/pathogens9010031.

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Streptococcus suis remains an important challenge for the worldwide swine industry. Considering that Brazil is a major pork producer and exporter, proper monitoring of the pathogen and resistance rates are required. We present here the characterization of Brazilian S. suis strains isolated over a 15 year period by pulsed-field gel electrophoresis (PFGE) typing, capsular, virulence, and antimicrobial resistance profiling. Serotype prevalence revealed a predominance of serotype 2/½ followed by 3, 7, 1/14, 6, 8, 18, 28, and 27; the latter had not yet been reported in Brazil. Resistance profiling
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Madar Johansson, Miralda, Eva Bélurier, Anastassios C. Papageorgiou, et al. "The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease." Journal of Biological Chemistry 295, no. 42 (2020): 14305–24. http://dx.doi.org/10.1074/jbc.ra120.014818.

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Streptococcus suis is part of the pig commensal microbiome but strains can also be pathogenic, causing pneumonia and meningitis in pigs as well as zoonotic meningitis. According to genomic analysis, S. suis is divided into asymptomatic carriage, respiratory and systemic strains with distinct genomic signatures. Because the strategies to target pathogenic S. suis are limited, new therapeutic approaches are needed. The virulence factor S. suis adhesin P (SadP) recognizes the galabiose Galα1–4Gal-oligosaccharide. Based on its oligosaccharide fine specificity, SadP can be divided into subtypes PN
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Wang, Mingliu, Pengcheng Du, Jianping Wang, et al. "Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China." Pathogens 8, no. 4 (2019): 187. http://dx.doi.org/10.3390/pathogens8040187.

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Streptococcus suis is an important zoonotic pathogen. Serotype 2 and sequence type (ST) 1 are the most frequently reported strains in both infected humans and pigs. ST7 is only endemic to China, and it was responsible for outbreaks in 1998 and 2005 in China. In the present study, 38 sporadic ST7 S. suis strains, which mostly caused sepsis, were collected from patients in the Guangxi Zhuang Autonomous Region (GX) between 2007 and 2018. Of 38 sporadic ST7 strains, serotype 14 was the most frequent (27 strains, 71.1%), followed by serotype 2 (11 strains, 28.9%). The phylogenetic structure of the
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Meng, F., N. H. Wu, A. Nerlich, G. Herrler, P. Valentin-Weigand, and M. Seitz. "Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process." Infection and Immunity 83, no. 7 (2015): 2806–15. http://dx.doi.org/10.1128/iai.00171-15.

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Swine influenza virus (SIV) andStreptococcus suisare common pathogens of the respiratory tract in pigs, with both being associated with pneumonia. The interactions of both pathogens and their contribution to copathogenesis are only poorly understood. In the present study, we established a porcine precision-cut lung slice (PCLS) coinfection model and analyzed the effects of a primary SIV infection on secondary infection byS. suisat different time points. We found that SIV promoted adherence, colonization, and invasion ofS. suisin a two-step process. First, in the initial stages, these effects w
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King, Samantha J., Peter J. Heath, Inmaculada Luque, Carmen Tarradas, Christopher G. Dowson, and Adrian M. Whatmore. "Distribution and Genetic Diversity of Suilysin inStreptococcus suis Isolated from Different Diseases of Pigs and Characterization of the Genetic Basis of Suilysin Absence." Infection and Immunity 69, no. 12 (2001): 7572–82. http://dx.doi.org/10.1128/iai.69.12.7572-7582.2001.

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ABSTRACT Streptococcus suis is an economically important pathogen of pigs responsible for a variety of diseases including meningitis, septicemia, arthritis, and pneumonia, although little is known about the mechanisms of pathogenesis or virulence factors associated with this organism. Here, we report on the distribution and genetic diversity of the putative virulence factor suilysin, a member of the thiol-activated toxin family of gram-positive bacteria. On the basis of PCR analysis of over 300 isolates of S. suis, the suilysin-encoding gene, sly, was detected in 69.4% of isolates. However, sl
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Cooper, V. L., A. R. Doster, R. A. Hesse, and N. B. Harris. "Porcine Reproductive and Respiratory Syndrome: NEB-1 PRRSV Infection did not Potentiate Bacterial Pathogens." Journal of Veterinary Diagnostic Investigation 7, no. 3 (1995): 313–20. http://dx.doi.org/10.1177/104063879500700303.

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A 2-phase study was conducted to evaluate the ability of the NEB-1 strain of porcine reproductive and respiratory syndrome virus (PRRSV) to potentiate common bacterial pathogens of swine. In phase I, 25 of 50 4-5-week-old specific-pathogen-free (SPF) pigs were exposed to NEB-1 PRRSV (day 0). Seven days after virus inoculation, 8 groups received 1 of 4 bacterial pathogens: Haemophihs parasuis, Streptococcus suis, Salmonella cholerasuis, and Pasteurella multocida. The ability of NEB-1 PRRSV to produce clinical disease, viremia, neutralizing antibody, gross and microscopic lesions and to potentia
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Thanawongnuwech, R., G. B. Brown, P. G. Halbur, J. A. Roth, R. L. Royer, and B. J. Thacker. "Pathogenesis of Porcine Reproductive and Respiratory Syndrome Virus-induced Increase in Susceptibility to Streptococcus suis Infection." Veterinary Pathology 37, no. 2 (2000): 143–52. http://dx.doi.org/10.1354/vp.37-2-143.

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Eighty 3-week-old crossbred pigs were randomly assigned to six groups (13–14 pigs/group). Group 1 pigs served as uninoculated controls, group 2 pigs were inoculated intranasally (IN) with Streptococcus suis serotype 2, group 3 pigs were inoculated IN with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine, group 4 pigs were inoculated IN with the same vaccine and with S. suis, group 5 pigs were inoculated IN with VR-2385 (a high-virulence strain of PRRSV), and group 6 pigs were inoculated IN with VR-2385 and S. suis. Pigs exposed to both PRRSV and S. suis were
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Amass, Sandra F., Ching Ching Wu, and L. Kirk Clark. "Evaluation of Antibiotics for the Elimination of the Tonsillar Carrier State of Streptococcus Suis in Pigs." Journal of Veterinary Diagnostic Investigation 8, no. 1 (1996): 64–67. http://dx.doi.org/10.1177/104063879600800110.

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Seventy clinically normal 13-day-old crossbred pigs from 10 litters from a Streptococcus suis-infected herd were randomly assigned by litter and weight to 7 groups of 10 pigs each to determine whether different antibiotic regimens would eliminate the tonsillar carrier state of S. suis. Six antimicrobial regimens were tested: penicillin intramuscularly (IM) once daily (s.i.d.) for 3 consecutive days; penicillin IM s.i.d. for 5 consecutive days; ampicillin IM s.i.d. for 5 consecutive days; ampicillin per os s.i.d. for 5 consecutive days; ampicillin intranasally s.i.d. for 5 consecutive days; and
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Stanojkovic, А., М. M. Petrovic, Z. Skrbic, et al. "Biochemical characteristics of Streptococcus suis strains isolated from healthy and deceased pigs." Biotehnologija u stocarstvu 30, no. 4 (2014): 699–704. http://dx.doi.org/10.2298/bah1404699s.

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The aim of this study was to determine the biochemical properties of Streptococcus suis strains isolated from healthy and deceased pigs. For this research we tested 34 S. suis strains isolated from deceased pigs that had clinical signs of septicemia and meningitis, as well as from clinically healthy pigs. The strains that have been already confirmed with specific antisera were tested using commercial battery of biochemical tests (API 20 Strep and ID 32 Strep) to determine the dominant biochemical characteristics that can be used in diagnosis of bacterial infection if specific S. suis antisera
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Li, Yuanyi, Marcelo Gottschalk, Miriam Esgleas, et al. "Immunization with Recombinant Sao Protein Confers Protection against Streptococcus suis Infection." Clinical and Vaccine Immunology 14, no. 8 (2007): 937–43. http://dx.doi.org/10.1128/cvi.00046-07.

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ABSTRACT Sao is a Streptococcus suis surface protein recently identified as a potential vaccine candidate. In this study, recombinant Sao in combination with Quil A provided cross-protection against S. suis serotype 2 disease in mouse and pig vaccination protocols. Subcutaneous immunization of mice elicited strong immunoglobulin G (IgG) antibody responses. All four IgG subclasses were induced, with the IgG2a titer being the highest, followed by those of IgG1, IgG2b, and IgG3. Challenge of the mice with S. suis strain 31533 resulted in a mortality rate of 80% for the control group, which receiv
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Baums, Christoph G., Gerd Josef Verk�hlen, Thomas Rehm, et al. "Prevalence of Streptococcus suis Genotypes in Wild Boars of Northwestern Germany." Applied and Environmental Microbiology 73, no. 3 (2006): 711–17. http://dx.doi.org/10.1128/aem.01800-06.

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ABSTRACT Invasive serotype 2 (cps2 +) strains of Streptococcus suis cause meningitis in pigs and humans. Four case reports of S. suis meningitis in hunters suggest transmission of S. suis through the butchering of wild boars. Therefore, the objective of this study was to investigate the prevalence of potentially human-pathogenic S. suis strains in wild boars. S. suis was isolated from 92% of all tested tonsils (n = 200) from wild boars. A total of 244 S. suis isolates were genotyped using PCR assays for the detection of serotype-specific genes, the hemolysin gene sly, and the virulence-associa
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Hatrongjit, Rujirat, Nahuel Fittipaldi, Marcelo Gottschalk, and Anusak Kerdsin. "Tools for Molecular Epidemiology of Streptococcus suis." Pathogens 9, no. 2 (2020): 81. http://dx.doi.org/10.3390/pathogens9020081.

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Diseases caused by Streptococcus suis are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between S. suis strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of S. suis populations as pathogenic or non-pathogenic, or disease-associated or non-disease as
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Vela, A. I., V. Sánchez, G. Mentaberre, S. Lavín, L. Domínguez, and J. F. Fernández-Garayzábal. "Streptococcus porcorum sp. nov., isolated from domestic and wild pigs." International Journal of Systematic and Evolutionary Microbiology 61, no. 7 (2011): 1585–89. http://dx.doi.org/10.1099/ijs.0.022657-0.

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Seven isolates of an unidentified Gram-stain-positive, catalase-negative, coccus-shaped organism isolated from domestic and wild pigs were characterized by phenotypic and molecular-genetic methods. Based on cellular morphology and biochemical criteria, the isolates were tentatively assigned to the genus Streptococcus, although the organisms did not appear to correspond to any recognized species. Comparative 16S rRNA gene sequencing showed that the unknown bacterium was phylogenetically closely related to, but distinct from, Streptococcus suis (97.5 % 16S rRNA gene sequence similarity to the ty
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Chiêu, Trần Thị Bích, Võ Minh Hoa, Phan Nhã Uyên, Trần Mạnh Hùng, Nguyễn Văn Vĩnh Châu, and Ngô Thị Hoa. "Development of an ELISA using the surface antigen one protein to detect for Streptococcus suis infection." Vietnam Journal of Biotechnology 14, no. 1 (2016): 169–79. http://dx.doi.org/10.15625/1811-4989/14/1/9307.

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Streptococcus suis (S. suis) is one of the most important pathogens to cause acute bacterial meningitis in Viet Nam and other Asia countries including Thailand and Hongkong. We investigated the potential of using ELISA with the SAO protein as antigen to detect for S. suis specific sero positive. An SAO specific antibody collected from hyperimmunised rabbits was employed to develop the prototype ELISA. S. suis and other bacterial pathogens were used to validate the sensitivity and specificity of this method. This prototype ELISA was validated using serum samples collected from meningitis patien
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Nomoto, R., F. Maruyama, S. Ishida, M. Tohya, T. Sekizaki, and Ro Osawa. "Reappraisal of the taxonomy of Streptococcus suis serotypes 20, 22 and 26: Streptococcus parasuis sp. nov." International Journal of Systematic and Evolutionary Microbiology 65, Pt_2 (2015): 438–43. http://dx.doi.org/10.1099/ijs.0.067116-0.

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In order to clarify the taxonomic position of serotypes 20, 22 and 26 of Streptococcus suis , biochemical and molecular genetic studies were performed on isolates (SUT-7, SUT-286T, SUT-319, SUT-328 and SUT-380) reacted with specific antisera of serotypes 20, 22 or 26 from the saliva of healthy pigs as well as reference strains of serotypes 20, 22 and 26. Comparative recN gene sequencing showed high genetic relatedness among our isolates, but marked differences from the type strain S. suis NCTC 10234T, i.e. 74.8–75.7 % sequence similarity. The genomic relatedness between the isolates and other
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