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Dissertations / Theses on the topic 'Streptozotocin model'

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Published: 28 June 2021

Last updated: 29 July 2025

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1

Грицюк, Мар'яна Іванівна, and Діана Ігорівна Навчук. "Streptozotocin model of diabetes mellitus." Thesis, Хист. Всеукраїнський медичний журнал молодих вчених. - Чернівці: БДМУ, Чернівці 2014, випуск 16., 2014, 2014. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8659.

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2

Shamsaldeen, Yousif. "Endothelial TRPV4 dysfunction in a streptozotocin-diabetic Rat Model." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17622.

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Diabetes mellitus is a complex disease characterised by chronic hyperglycaemia due to compromised insulin synthesis and secretion, or decreased tissue sensitivity to insulin, if not all three conditions. Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasodilation is impaired. The aim of this study was to examine the involvement of TRPV4 in diabetes endothelial dysfunction. Male Charles River Wistar rats (350-450 g) were injected with 65mg/kg streptozotocin (STZ) intraperitoneally. STZ-injected rats were compared with naïve rats (not injected with S

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3

Bahremand, Saeid. "Blood Glucose Management Streptozotocin-Induced Diabetic Rats by Artificial Neural Network Based Model Predictive Control." Thesis, Southern Illinois University at Edwardsville, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10249804.

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<p> Diabetes is a group of metabolic diseases where the body’s pancreas does not produce enough insulin or does not properly respond to insulin produced, resulting in high blood sugar levels over a prolonged period. There are several different types of diabetes, but the most common forms are type 1 and type 2 diabetes. Type 1 diabetes Mellitus (T1DM) can occur at any age, but is most commonly diagnosed from infancy to late 30s. If a person is diagnosed with type 1 diabetes, their pancreas produces little to no insulin, and the body’s immune system destroys the insulin-producing cel

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4

Kekatpure, Avantika. "Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase." Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/737.

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Objectives: To date little is known of the interaction between diabetes and sex hormones in the vasculature. A number of studies suggest that premenopausal diabetic women loose their gender based cardiovascular protection. However, there is insufficient evidence to explain the mechanism underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a gender difference in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the potential role of superoxide

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5

Thomas, Adam J. "Characterization of cAMP-Specific Phosphodiesterase-4 (R)-[11C]Rolipram Small Animal Positron Emission Tomography and Application in a Streptozotocin-Induced Model of Hyperglycemia." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19877.

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Elevated sympathetic nervous system (SNS) tone contributes to excess cardiac mortality associated with type 2 diabetes mellitus (T2DM). Chronic SNS stimulation has detrimental effects to the heart, in particular, with its cell signaling abilities. (R)-[11C]Rolipram small animal positron emission tomography (PET), an noninvasive nuclear imaging modality, was used to assess phosphodiesterase-4 (PDE4) alterations in a high fat diet (HFD), streptozotocin (STZ) induced model of hyperglycemia in rats. Prior to investigation in the animal model, characterization of (R)-[11C]rolipram small animal PET

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6

Ayeleso, Ademola Olabode. "Influence of two plant products (red palm oil and rooibos) on streptozotocin-induced hyperglycaemia and its implications on antioxidant status and other biochemical parameters in an animal model." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/1517.

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Thesis submitted in fulfilment of the requirements for the Doctor of Technology: Biomedical Technology In the Faculty of Health and Wellness At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY, 2012<br>Diabetes mellitus is a major health problem not only in urban, but also in the rural areas and is diagnosed by the presence of high glucose levels in the blood. Oxidative stress is known to be actively involved in the onset and progression of diabetes and its complications. Antioxidants have important roles in biological systems by scavenging free radicals which may result in oxidative damage of biol

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7

Sakai, Takeru. "Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet." Kyoto University, 2015. http://hdl.handle.net/2433/195969.

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8

Kusakabe, Toru. "Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet." Kyoto University, 2009. http://hdl.handle.net/2433/124316.

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9

Haley, James M. "Ex Vivo Evaluation of Myocardial Beta-Adrenergic Receptors in High-Fat Fed STZ and ZDF Models of Diabetes Using [3H]-CGP12177." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30363.

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Diabetes mellitus (DM) and hyperglycemia contribute to sympathetic nervous system (SNS) activation and cardiovascular dysfunction. SNS activation and increased norepinephrine levels downregulate cardiac β-adrenergic receptors (β-AR). The ADMIRE-HF trial identified reduced cardiac SNS innervation as an independent prognostic marker in heart failure. The β-AR antagonist [3H]-CGP12177 was used to quantify cardiac β-AR in ex vivo biodistribution studies in streptozotocin (STZ)-treated rats after 8 weeks of sustained hyperglycemia, and in the Zucker Diabetic Fatty (ZDF) rat model of type-2 diabetes

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10

Wong, Ching-keung, and 黃靜強. "The effects of streptozotocin-diabetes on adrenomedullin gene expression and peptide levels in the gastrointestinal system of therat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45011503.

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11

Esteves, Ingrid de Miranda. "Caracterização das alterações na via hipocampo-córtex pré-frontal medial em modelo farmacológico da doença de Alzheimer." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-26082016-110343/.

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Severas altera¸c~oes no metabolismo energ´etico, no consumo de glicose e na sinaliza¸c~ao de insulina cerebral est~ao presentes na doen¸ca de Alzheimer (DA). O modelo animal da DA obtido pela administra¸c~ao intracerebroventricular de estreptozotocina (STZ-icv) em ratos induz um estado de resist^encia `a insulina no c´erebro associado `a disfun¸c~oes colin´ergicas e a d´eficits cognitivos, tornando-o um dos poucos modelos experimentais da forma espor´adica da DA. Este trabalho tem como objetivo caracterizar, neste modelo, as disfun¸c~oes sin´apticas na via hipocampo - c´ortex pr´e-frontal medi

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12

Neel, Sarah Elizabeth. "Transplantation of iPS cells reduces apoptosis and fibrosis and improves cardiac function in streptozotocin-induced diabetic rats." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4686.

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Background: Streptozotocin (STZ) induced diabetes leads to various complications including cardiomyopathy. Recent data suggests transplanted bone marrow stem cells improve cardiac function in diabetic cardiomyopathy. However, whether modified ES, iPS cells, or factors released from these cells can inhibit apoptosis and fibrosis remains completely unknown. The present study was designed to determine the effects of transplanted ES cells overexpressing pancreatic transcription factor 1 a (Ptf1a), a pro-pancreatic endodermal transcription factor, iPS cells, or their respective conditioned media (C

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13

Hill, Cindy. "The efficacy of Diavite tm (Prosopis glandulosa) as anti-diabetic treatment in rat models of streptozotocin-induced type 1 diabetes and diet-induced-obese insulin resistance." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4173.

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Thesis (MScMedSc (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: Introduction: Obesity and its associated complications, such as the metabolic syndrome, hypertension and cardiovascular disease, are escalating worldwide. In recognition of this, untested remedies advertised as anti-diabetic agents are flooding the market. Many of these products have limited efficacy, limited tolerability and significant side-effects. One remedy, claiming to have anti-diabetic properties, is DiaviteTM. DiaviteTM, a herbal product, consisting solely of the dried a

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14

Wick, Matthias Christian [Verfasser], Julian [Gutachter] Widder, and Carola [Gutachter] Förster. "Einfluss des Multidrug Resistance Protein-1 auf die vaskuläre Funktion im Modell des Streptozotocin-induzierten Diabetes der Maus / Matthias Christian Wick. Gutachter: Julian Widder ; Carola Förster." Würzburg : Universität Würzburg, 2013. http://d-nb.info/111098457X/34.

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15

Kergoat, Micheline. "Secretion et mode d'action de l'insuline dans un modele de diabete non-insulinodependant chez le rat." Paris 7, 1988. http://www.theses.fr/1988PA077085.

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16

Peroni, Odile. "Mesure de la néoglucogénèse chez le rat à l'aide de [2-13C] glycérol et de l'analyse de la distribution des isotopomères de masse du glucose : étude in vitro (foies isolés perfusés) chez l'animal sain et in vivo chez l'animal sain ou présentant un diabète insulinopénique induit par la streptozotocine." Lyon 1, 1997. http://www.theses.fr/1997LYO1T321.

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17

Hatch, Jennifer. "Sex-Specific Bone Phenotype in the Streptozotocin-Induced Murine Model of Diabetes." Thesis, 2021. http://dx.doi.org/10.7912/C2/77.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Bone disease and degradation is a ubiquitous problem, the complexity and treatment of which humanity has only begun to understand. Diabetes Mellitus is a disease which, in all forms, profoundly effects the organs of the body, bone included. As is often the case in biology, there are inherent differences between the sexes when considering skeletal development and disease progression and outcome. Although there are several reported mouse models for diabetes, until now there has been no characterization of bone disease in any model wher

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18

Wilson, Rachel Dorothy. "Fructose-fed streptozotocin-injected rat : an alternative model for type 2 diabetes." Thesis, 2011. http://hdl.handle.net/10413/9222.

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The principal objective of this study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60g) were randomly divided into six groups namely: Normal Control (NC), Diabetic/Streptozotocin Control (STZ), Fructose-10 (FR10+STZ), Fructose-20 (FR20+STZ), Fructose-30 (FR30+STZ) and Fructose-40 (FR40+STZ) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad li

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19

Huang, Yu-Hsun, and 黃昱勳. "Intervention with Cilostazol Attenuates Retinal Inflammation in a Streptozotocin-Induced Diabetic Animal Model." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/92316810639778169720.

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碩士<br>臺灣大學<br>臨床醫學研究所<br>98<br>1.Background: Among working adults in developed countries, diabetic retinopathy (DR) remains the leading cause of blindness and visual impairment. New evidence indicates that DR shares similarities with chronic inflammatory disease, and inflammation may play a central role in the development of DR. In diabetes, leukocytes become less deformable and retinal leukostasis increases, corresponding to the fact that the expression of cellular adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) are increased in retinal vasculature, which affects retinal

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20

Khanjari, Dehnavi Ashraf. "The kallikrein-kinin system in relation to retinal vessel tone in the streptozotocin-diabetic rat model." Thèse, 2002. http://hdl.handle.net/1866/14183.

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21

Huang, Hsin-Wei, and 黃信偉. "Effect of Astaxanthin on the Expression of Retinal Oxidative Stress Mediators in Streptozotocin-induced Diabetic Animal Model." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/32640056691811409792.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>99<br>1.Background Diabetic retinopathy, a sight-threatening complication of diabetes, is the major cause of blindness in young adults. Studies have documented that sustained hyperglycemia is the instigating cause of disrupted normal cellular metabolism leading to the development of retinopathy. Diabetes increases oxidative stress, and increased oxidative stress is one of the key regulators in the development of diabetic complications. Oxidative stress results from an imbalance between oxidant production, including reactive oxygen species (ROS), reactive nitr

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22

Naidoo, Pragalathan. "Development of an alternative non-obese non-genetic rat model of type 2 diabetes using caffeine and streptozotocin." Thesis, 2013. http://hdl.handle.net/10413/11410.

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The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Caffeine 5 mg/kg BW + STZ (CAF5), Caffeine 10 mg/kg BW + STZ (CAF10), Caffeine 20 mg/kg BW + STZ (CAF20) and Caffeine 40 mg/kg BW + STZ (CAF40) and were fed a commercially available rat pellet diet and normal drinking water ad libitum throughout the 13 weeks experimental period. After a one week acclimatization period, diabetes was induced in the anim

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23

Lin, Yu-Yen, and 林佑彥. "Changes of Synaptic Plasticity Gene Expression by Electroacpuncture (EA) and Local Somatothermal Stimulation (LSTS) in Mice Model of Streptozotocin-Induced Diabetes Mellitus." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/6xnv74.

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24

Svobodová, Eva. "Porovnání transgenního a streptozotocinového modelu Alzheimerovy choroby: validace systému IntelliCage pro behaviorální fenotypizaci." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-445851.

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Animal models of Alzheimer's disease display cognitive insufficiencies which mimic human symptoms and occur at a given age or post-treatment time. Animals are typically tested using canonical behavioral tests, lasting minutes and taking place mostly in the non-active period of the daily cycle. Animals are exposed to certain amounts of manipulation-induced stress. Our work represents a validation study for the rat behavioral system IntelliCage. The tested individuals live freely in a group and their behavior is monitored continuously. It is however possible to set up individual tests for each a

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25

Cho, Yi-Li, and 卓怡利. "Effects of long-term treatment of aminoguanidine on the mechanical properties of the arterial system in a new model of streptozotocin-nicotinamide rats." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/31016805604151523903.

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碩士<br>國立臺灣大學<br>生理學研究所<br>93<br>A new experimental type 2 diabetic syndrome, which is closer to human non-insulin-dependent diabetes mellitus, has been reported in adult rats administered streptozotocin (STZ) and partially protected with a suitable dose of nicotinamide (NA). The accelerated formation of advanced glycation end products (AGEs) on long-lived connective tissue may account for some of the complications of diabetes such as stiffing of collagen, vascular narrowing, and arterial stiffing. In this study, we determined the effects of long-term treatment with aminoguanidine (AG), an inhi

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26

Wick, Matthias Christian. "Einfluss des Multidrug Resistance Protein-1 auf die vaskuläre Funktion im Modell des Streptozotocin-induzierten Diabetes der Maus." Doctoral thesis, 2013. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-97473.

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Vaskuläre Komplikationen wie Atherosklerose sind bei Diabetikern weit verbreitet. Eine erhöhte Produktion reaktiver Sauerstoffspezies trägt zu einer Dysfunktion des Endothels bei Diabetes und hohen Glukosespiegeln bei. Glutathion (GSH) ist das häufigste zelluläre Thiol und stellt ein bedeutendens Antioxidans des menschlichen Organismus dar. Das Multidrug Resistance Protein 1 (MRP 1) ist im Endothel der Haupttransporter von oxidiertem GSH. Blockiert man MRP 1, so wird unter oxidativem Stress der intrazelluläre GSH-Spiegel erhalten. In dieser Arbeit wird der Einfluss von MRP 1 auf die endothelia

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27

Valášková, Eliška. "Vliv diabetes mellitus na reprodukční parametry a expresi vybraných testikulárních genů na myším modelu." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-345066.

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According to the World Health Organization (WHO), 15% of couples in reproductive age suffer from infertility problems, and up to 60% of cases are caused by male factor. Causes of this condition could be genetic background, environmental factors and various diseases, including diabetes mellitus (DM). The aim of this study was to investigate the effects of DM on reproductive parameters and expression of selected testicular genes using mouse model (FVB inbred mouse strain). DM (type 1) was artificially induced by chemical substance streptozotocin, which causes destruction of pancreatic β cells. T

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28

Lee, Yu-Chen, and 李育臣. "Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/58006148886172431989.

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博士<br>中國醫藥大學<br>中醫學系博士班<br>99<br>Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg-1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15Hz) was a

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