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Journal articles on the topic 'Streptozotocin model'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Hady, Keita. "LIPOPEROXIDATION AND VASCULAR REACTIVITY RESPONSE IN RAT MODELS OF STREPTOZOTOCININDUCED DIABETES MELLITUS." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1102–9. https://doi.org/10.5281/zenodo.163852.

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The murine model of streptozotocin-induced diabetes mellitus has been widely used for many authors. However, there are meaningful discrepancies about the functional alterations reported; especially regarding vascular response. Objective: The objective of the present study was to examine how the prolonged effects of diabetes mellitus induced by administering streptozotocin affects vascular reactivity, lipoperoxidation and endothelial function in aortic rings and if the administration of nicotinamide will partially protect those adverse outcomes. Performing parallel studies could contribute in p

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2

Miao, Ming San, Bo Lin Cheng, and Na Jiang. "Effect of Sophora Japonica Total Flavonoids on Mouse Models of Hyperglycemia and Diabetes Model." Applied Mechanics and Materials 664 (October 2014): 397–401. http://dx.doi.org/10.4028/www.scientific.net/amm.664.397.

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Objective: To investigate the effects of Sophora japonica total flavonoids hyperglycemia and diabetes in mice models. Methods: intraperitoneal injection of epinephrine, intravenous injection of freshly prepared alloxan or intravenous injection of streptozotocin, alloxan build adrenaline or hyperglycemia model streptozotocin diabetic model. Glucose values were selected for each experiment> 11.1mmol / L, with a significantly more drinking, eating, and more urinary symptoms in mice 60, according to blood glucose levels were randomly divided into six groups, namely large, medium and small dos

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3

Skaletskaya, G. N., N. N. Skaletskiy, E. A. Volkova, and V. I. Sevastyanov. "Streptozotocin model of stable diabetes mellitus." Russian Journal of Transplantology and Artificial Organs 20, no. 4 (2019): 83–88. http://dx.doi.org/10.15825/1995-1191-2018-4-83-88.

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Aim:to create a model of stable experimental diabetes mellitus (DM) in laboratory rats using streptozotocin (STZ).Materials and methods.The dynamics of changes in glycemia and survival in 60 Wistar rats was determined. STZ at a dosage of 70 mg/kg was administered to these rats in two ways: once and fractionally (within 5 days).Results.After a single injection of the STZ, 6 out of 30 rats (20%) died, in 7 cases (23.3%) a spontaneous reversion of the diabetic status occurred and in 17 animals (56.6%) the DM remained stable throughout the observation period (8 weeks). After the fractional adminis

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4

Pratiwi, Egi Claudia, Elsa Trinovita, and Agnes Immanuela Toemon. "Literatur Review: Hubungan Model Hewan Coba (Faktor Jenis Kelamin dan Hormon) pada Sensitivitas Induksi Streptozotocin sebagai Agen Diabetogenik." Jurnal Surya Medika 7, no. 2 (2022): 132–41. http://dx.doi.org/10.33084/jsm.v7i2.2646.

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Diabetes mellitus (DM) is a metabolic disease that global concern and characterized by hyperglycemia. Tests for antidiabetic agents, either discovering new drugs or antidiabetic components, have been developed using experimental animals induced with the diabetogenic agent streptozotocin. The side effects of streptozotocin were reported lower than alloxan. The sensitivity of streptozotocin induction can be relied on by several factors such as sex and hormones—the difference in results in several studies regarding the relationship between streptozotocin induction sensitivity with gender. The res

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5

Rahman, Nurdin, I. Made Tangkas, Sri Muliyani Sabang, Bohari Bohari, and Rukman Abdullah. "The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 849–53. http://dx.doi.org/10.3889/oamjms.2021.7065.

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Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% suc

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6

Fajarwati, Indah, Dedy Duryadi Solihin, Tutik Wresdiyati, and Irmanida Batubara. "Administration of alloxan and streptozotocin in Sprague Dawley rats and the challenges in producing diabetes model." IOP Conference Series: Earth and Environmental Science 1174, no. 1 (2023): 012035. http://dx.doi.org/10.1088/1755-1315/1174/1/012035.

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Abstract Alloxan and streptozotocin are the most prominent diabetogenic agents in diabetes research. However, most published reports do not represent the practical importance of their application. The present study evaluated alloxan and streptozotocin with various doses to determine the optimal diabetic model in Sprague Dawley rats. This study also identified the challenges in inducing diabetes using both agents. Every dose of alloxan (120, 150, 180 mg/kg) and streptozotocin (40, 50, 60 mg/kg) was administered through intraperitoneal injection. The results showed that alloxan-induced rats prod

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7

Malaisse, Willy J., Marie-Hélène Giroix, Dagmar Zähner, Greta Marynissen, Abdullah Sener, and Bernard Portha. "Neonatal streptozotocin injection: A model of glucotoxicity?" Metabolism 40, no. 10 (1991): 1101–5. http://dx.doi.org/10.1016/0026-0495(91)90137-l.

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8

Mahata, Liganda Endo, Hirowati Ali, and Arina Widya Murni. "Effect of Streptozotocin on Liver Histology Damage in Rats Model of Gestational Diabetes Mellitus." International Journal of Research and Review 8, no. 9 (2021): 18–22. http://dx.doi.org/10.52403/ijrr.20210904.

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Background: Gestational Diabetes Mellitus (GDM) is a disorder of carbohydrate metabolism that causes hyperglycemia, insulin resistance and failure of organs especially the liver. There is great interest in understanding the pathophysiology and treatment of GDM. Due to ethical issues involving human studies, it is necessary to use animal models to understand pathophysiology and potential treatment for GDM. Streptozotocin-induced diabetes mellitus in pregnant rats was commonly used by several author. Aims: The aim of this study is to investigate the effect of streptozotocin (STZ) on liver histol

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9

Vastyanov, R. S., and O. V. Chekhlova. "Pathophysiological model of indirect revascularization in rats with microangiopathy of limbs caused by experimental streptozocin diabetes." Reports of Morphology 25, no. 4 (2019): 24–29. http://dx.doi.org/10.31393/morphology-journal-2019-25(4)-04.

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Despite the large number of publications, the model of experimental diabetes after the introduction of streptozotocin remains a subject of lively scientific debate. The purpose of this study was to develop a pathophysiological model of indirect revascularization in rats with microangiopathy of limbs caused by experimental streptozotocin diabetes. Experimental studies were carried out in a chronic experiment on 100 sexually mature Wistar rats weighing 180-250 g. The streptozotocin diabetes model used. After culling animals from increased resistance to pancreatotropic toxicity by the criterion o

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10

Ermakova, P. S., L. A. Lugovaya, E. A. Vasilchikova, et al. "Model of the formation of streptozotocin-induced diabetes in Wiesenau pigs with assessment of its effectiveness and stability." Diabetes mellitus 28, no. 2 (2025): 111–23. https://doi.org/10.14341/dm13168.

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BACKGROUND: Research aimed at creating and validating models of diabetes plays an important role in the development of new treatments for this disease. Large animal models may bridge the gap between basic research and clinical trials of new technologies for the treatment of insulin deficiency. At the moment, the most popular model is streptozotocin-induced diabetes. However, different species and breeds of animals respond differently to streptozotocin. Thus, although models already exist in different breeds of pigs, verification of the Wiesenau pig model of streptozotocin-induced diabetes is a

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11

Alp Düz, Çağrı, Çiğdem Özer, Fathia Hussein Mohamed Mohamed, et al. "The effects of systemic adropin administration on biochemical and morphological effects in diabetic nephropathy: a rat model study." Veterinarski arhiv 95, no. 3 (2025): 327–38. https://doi.org/10.24099/vet.arhiv.2670.

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The aim of the study was to investigate the biochemical and morphological effects of systemic adropin adminis- tration on renal tissue in streptozotocin-induced diabetic nephropathy in rats. The animals were divided into 4 groups as follows: control, adropin, diabetes, diabetes+adropin. The diabetic groups received a single dose of intraperitoneal streptozotocin (65 mg/kg). The fasting blood glucose level for diabetes was defined as at least 250 mg/dl. Eight weeks after administration of streptozotocin and/or the streptozotocin solvent to the adropin groups, 450 nmol/kg adropin was administere

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12

Alipin, Kartiawati, and Elsha Prastiwi. "KARAKTERISTIK HISTOLOGIS TESTIS TIKUS (Rattus norvegicus Berkenhout, 1769) MODEL DIABETES YANG DIINDUKSI STREPTOZOTOCIN." BIOTIKA Jurnal Ilmiah Biologi 19, no. 1 (2021): 33–38. https://doi.org/10.24198/biotika.v19i1.32348.

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Diabetes mellitus (DM) adalah penyakit kronis yang ditandai dengan kadar glukosa darah yang tinggi akibat pengaturanhomeostasis glukosa terganggu. Kondisi DM pada hewan uji dapat dilakukan dengan menginduksi diabetogenstreptozotocin. Diabetes mellitus dapat menyebabkan impotensi, gangguan ejakulasi, merusak spermatogenesis, fungsikelenjar seks aksesori dan berbagai penyakit sistemik pada fertilitas pria. Penurunan proses spermatogenesis dapat dilihatdari histologis testis terutama pada bagian kompartemen. Penelitian ini bertujuan untuk mengetahui karakteristikhistologis testis tikus model diab

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13

GAO, Yu, Jin-hui WU, and Lin LIU. "Streptozotocin-induced early diabetic retinopathy model in rats." Academic Journal of Second Military Medical University 30, no. 10 (2010): 1053–59. http://dx.doi.org/10.3724/sp.j.1008.2010.01053.

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14

Zhang, Jun, Ting Ding, Ximei Zhang, Dongxing Tang, and Jianping Wang. "Dapagliflozin relieves renal injury in a diabetic nephropathy model by inducing autophagy through regulation of miR-30e-5p/AKT/mTOR pathway." Tropical Journal of Pharmaceutical Research 21, no. 10 (2022): 2115–23. http://dx.doi.org/10.4314/tjpr.v21i10.11.

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Purpose: To investigate the mechanism of action of dapagliflozin on diabetic nephropathy.  Methods: A rat model of diabetic nephropathy was established by injection of fructose-streptozotocin. Blood glucose and urinary protein levels were measured, while histopathological changes in kidney tissues were determined by hematoxylin & eosin staining (H & E). Serum levels of creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and lactate dehydrogenase (LDH) were evaluated by enzyme-linked immunosorbent assay (ELISA).

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15

Zhu, Lei, Zhen Zhang, Xiao-jie Hou, Yong-feng Wang, Jing-yu Yang, and Chun-fu Wu. "Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model." Brain Research 1722 (November 2019): 146344. http://dx.doi.org/10.1016/j.brainres.2019.146344.

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16

Kumar, Anuj, Akhilesh Kumar Rana, Amit Singh, and Alok Singh. "Effect of Methanolic Extract of Phyllanthus niruri on Leptin Level in Animal Model of Diabetes Mellitus." Biomedical and Pharmacology Journal 12, no. 1 (2019): 57–63. http://dx.doi.org/10.13005/bpj/1613.

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To study the effect of methanolic extract of Phyllanthus niruri on animal model of Diabetes Mellitus. Diabetes Mellitus was induced in rats by injecting Streptozotocin (60mg/kg) intraperitonealy. Blood glucose was measured on day 3 by GOD-POD method. Rats having fasting blood glucose >250 mg/dl were further selected for study. Four groups were created i.e. Control, Control+Streptozotocin, Streptozotocin+ Metformin(75mg/kg) and Streptozotocin+ extract of P. niruri (250mg/kg). Each group was consisting of 6 rats of either sex. Metformin and experimentalextract were administered for 21 days. B

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17

Sahana, Abhijit, Kunal Kunal Gupta, Mainak Chakraborty, Naineet Santra, Swarupananda Mukherjee, and Nilanjan Sarkar. "Pre-Clinical Evaluation of Anti-Diabetic Activity of Phyllanthus Reticulatus Fruit Extract." Journal of Advanced Zoology 44, S-5 (2023): 1449–52. http://dx.doi.org/10.17762/jaz.v44is-5.1285.

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Anti-diabetic activity of Phyllanthus Reticulatus fruit extract was carried out against streptozotocin induced diabetic model in wistar rats. Soxhlet extraction using methanol was carried out on Phyllanthus Reticulatus fruit to obtain the extract. Acute Oral Toxicity– Acute Toxic Class Method 423 was performed to obtain the low and high doses respectively at 300 mg/kg and 600 mg/kg. Experiment using streptozotocin as diabetic model was actioned. The parameters which were evaluated were body weight, blood glucose, SOD (superoxide dismutase), CAT (catalase), GSH (glutathione), MDA (malondial- de

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18

Botolin, Sergiu, and Laura R. McCabe. "Bone Loss and Increased Bone Adiposity in Spontaneous and Pharmacologically Induced Diabetic Mice." Endocrinology 148, no. 1 (2007): 198–205. http://dx.doi.org/10.1210/en.2006-1006.

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Insulin-dependent diabetes mellitus (IDDM) is associated with increased risk of osteopenia/osteoporosis in humans. The mechanisms accounting for diabetic bone loss remain unclear. Pharmacologic inducers of IDDM, such as streptozotocin, mimic key aspects of diabetes in rodents, allow analysis at the onset of diabetes, and induce diabetes in genetically modified mice. However, side effects of streptozotocin, unrelated to diabetes, can complicate data interpretation. The nonobese diabetic (NOD) mouse model develops diabetes spontaneously without external influences, negating side effects of induc

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19

Ji, Lei, Xue Zhong, Xingxing Xia, Wei Yu та Yuping Qin. "Protective effect of syringaresinol on rats with diabetic nephropathy via regulation of Nrf2/HO-1 and TGF- β1/Smads pathways". Tropical Journal of Pharmaceutical Research 20, № 2 (2022): 275–80. http://dx.doi.org/10.4314/tjpr.v20i2.8.

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    Purpose: To investigate the protective role of syringaresinol in a rat model of diabetic nephropathy (DN). Methods: Streptozotocin was injected intraperitoneally into rats to establish the diabetic model. Streptozotocin-induced rats were orally administered syringaresinol, and pathological changes in kidneys were assessed using hematoxylin and eosin staining. Enzyme-linked immunosorbent assay (ELISA) was used to determine kidney injury indicators, 24-h urine proteins, blood urea nitrogen (BUN), and serum creatinine (SCR). Blood glucose was measured using a blo

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20

Parlow, Jaqueline Meert, Ana Cristina Barth de Castro, Fabio Vinicius Barth, et al. "Integrative analysis on the effects of streptozotocin in the experimental model for diabetization in wistar rats: histological and laboratory study." Brazilian Journal of Health Review 7, no. 2 (2024): e68256. http://dx.doi.org/10.34119/bjhrv7n2-171.

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The study of complications of diabetes mellitus is important to understand the alterations on the specific tissues affected by this chronic disease. An animal model that simulated this complication is necessary for further treatments and prevention of diabetes complications. The aim of this study was evaluated the biochemical and histological alterations on liver, kidney, small gut and retina tissues. The animal assay was made with 15 wistar rats divided in two groups: a control group, consisting of 5 rats that were healthy and non-diabetic (CONTROL), and a streptozotocin group (STZ), consisti

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Gvazava, I. G., A. V. Kosykh, O. S. Rogovaya, et al. "A Simplified Streptozotocin-Induced Diabetes Model in Nude Mice." Acta Naturae 12, no. 4 (2020): 98–104. http://dx.doi.org/10.32607/actanaturae.11202.

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Preclinical studies of human cellular and tissue-based products (HCT/Ps) for transplantation therapy of type 1 diabetes mellitus (T1DM) necessarily involve animal models, particularly mouse models of diabetes induced by streptozotocin (STZ). These models should mimic the clinical and metabolic manifestations of T1DM in humans (face validity) and be similar to T1DM in terms of the pathogenetic mechanism (construct validity). Furthermore, since HCT/Ps contain human cells, modeling of diabetes in immune-deficient animals is obligatory. Here we describe the most simplified diabetes model in Nude m

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22

Miao, Ming San, Bo Lin Cheng, Na Jiang, and Mei Qiong Jiang. "Qumai Total Flavonoids Induced Diabetic Mice Model of Streptozotocin." Applied Mechanics and Materials 664 (October 2014): 410–14. http://dx.doi.org/10.4028/www.scientific.net/amm.664.410.

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Purpose: Research Qumai total flavonoids induced diabetic mice model of streptozotocin. Methods: 12 h after fasting groups of mice, Tail vein injection of citrate buffer chain urea with cephalosporins solution (80mg/kg,0.02ml/10g), To 1 times a day. In dosing 10, 20, 30 days tail blood glucose measurement value. On the 30th day fasting 12 h after the last for 1 h, Some blood, Measuring blood glucose、Glycosylation of serum protein, Serum insulin、Insulin resistance value;After the death in mice,Take the liver glycogen original value;Take the pancreas, and kidneys,10% formalin fixed liquid, As a

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23

Yoshiyama, Yuji, Takashi Sugiyama, and Motoko Kanke. "Experimental Diabetes Model in Chick Embryos Treated with Streptozotocin." Biological & Pharmaceutical Bulletin 28, no. 10 (2005): 1986–88. http://dx.doi.org/10.1248/bpb.28.1986.

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24

Koulmanda, Maria. "Islet transplant model in nonhuman primates: use of streptozotocin." Transplantation Reviews 20, no. 3 (2006): 126–30. http://dx.doi.org/10.1016/j.trre.2006.06.003.

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25

Heo, Jae-Hyeok, Kyoung-Min Lee, Sang-Rae Lee, et al. "P1-123: Streptozotocin-induced Alzheimer model in cynomolgus monkeys." Alzheimer's & Dementia 6 (July 2010): S210. http://dx.doi.org/10.1016/j.jalz.2010.05.672.

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26

Krisnamurti, Desak Gede Budi, Erni H. Purwaningsih, Tri Juli Edi Tarigan, Christian Marco Hadi Nugroho, Vivian Soetikno, and Melva Louisa. "Alterations of Liver Functions and Morphology in a Rat Model of Prediabetes After a Short-term Treatment of a High-fat High-glucose and Low-dose Streptozotocin." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 668–74. http://dx.doi.org/10.3889/oamjms.2022.8717.

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BACKGROUND: The administration of high-fat and high-glucose in diet followed by a low-dose streptozotocin injection in rats could mimic hyperglycemia, prediabetic, or diabetic conditions in humans. However, whether the rat model may lead to early liver impairment was still unclear. AIM: This study was aimed to investigate the possible changes in liver functions and morphology in the rat model of prediabetes after a short-term administration of a high-fat and high-glucose diet followed by low-dose streptozotocin injection. METHODS: Eighteen male Wistar rats were divided into nine rats in the co

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Badsha, Shahadat, Rakibul Islam, Mst Parvez, et al. "Effect of Gynura procumbens leaf extract with biological nanoparticles on streptozotocin-induced hyperglycemia in a rat model." Journal of Advanced Biotechnology and Experimental Therapeutics 7, no. 1 (2024): 255. http://dx.doi.org/10.5455/jabet.2024.d21.

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Herbal medicines, a popular choice for treatments, are effective against diabetes when used with nanoparticles. Thus, this study investigates the effects of Gynura procumbens ethanolic extract with chitosan nanoparticles on streptozotocin-induced hyperglycemia in rat model. Twenty-eight days old 16 male rats were randomly divided into 4 groups such as T0 = control (normal), T1 = streptozotocin-induced diabetes, T2 = streptozotocin-induced diabetes treated with ethanolic extract of Gynura Procumbens (150 mg/kg body weight), and T3= streptozotocin induced diabetes treated with ethanolic extract

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Muhammad, Faras Agiel Maulidan, Fatimah Nurmawati, and Rahniayu Alphania. "Challenges in creating diabetes mellitus animal model for physiological research." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 263–69. https://doi.org/10.5281/zenodo.12739705.

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from abnormalities in insulin secretion, insulin action, or both. Diabetes mellitus is one of the global health problems, and its prevalence continues to increase from year to year. Diabetes mellitus has several types, among which the most commonly encountered are type 1 diabetes and type 2 diabetes. Studies related to diabetes mellitus need to be conducted to understand preventive and curative measures that can be taken to address this disease. There are various methods that can be used to study diabet

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Baig, Mirza Anwar, and Shital Sharad Panchal. "Streptozotocin-Induced Diabetes Mellitus in Neonatal Rats: An Insight into its Applications to Induce Diabetic Complications." Current Diabetes Reviews 16, no. 1 (2019): 26–39. http://dx.doi.org/10.2174/1573399815666190411115829.

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Background: Diabetic complications are the major contributor in the mortality of diabetic patients despite controlling blood glucose level. In the journey of new drug discovery, animal models have to play a major role. A large number of chemical-induced and genetically modified animal models have been investigated to induce diabetic complications but none of them was found to be mimicking the pathophysiology of the human. Therefore, the search and identification of the appropriate animal model become essential. Objective: In the present review, we have made an attempt to understand the pathoph

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el-Seifi, S., J. M. Freiberg, J. Kinsella, L. Cheng, and B. Sacktor. "Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 252, no. 1 (1987): R40—R47. http://dx.doi.org/10.1152/ajpregu.1987.252.1.r40.

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The streptozotocin-induced diabetic rat was used to test the hypothesis that Na+-H+ exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of Na+, and stimulated Na+ pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H+ gradient-dependent Na+ uptake and Na+ gradient-dependent H+ flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals.

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Costa, Virginia Alice Vieira da, and Lucia Marques Vianna. "Biological response of spontaneously hypertensive rats to the streptozotocin administration." Brazilian Archives of Biology and Technology 51, no. 1 (2008): 43–48. http://dx.doi.org/10.1590/s1516-89132008000100006.

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The sensitivity of adult spontaneously hypertensive rats (SHR) to the diabetogenic effect of streptozotocin (STZ) was studied. The animals were subdivided into three groups: control (citrate buffer), streptozotocin 40 mg/kg or 50 mg/kg, and general biologic parameters were analyzed, in addition to systolic blood pressure, blood glucose and insulin levels determinations. Both doses were able to induce hyperglycemia above 300 mg/dl; however, 50 mg/kg provoked a more pronounced physiological alterations in body weight, diuresis, water and food intake. There was no change on systolic blood pressur

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Xu, Wenguang, Qiong Luo, Xiuying Wen, Ming Xiao, and Qijian Mei. "Antioxidant and anti-diabetic effects of caffeic acid in a rat model of diabetes." Tropical Journal of Pharmaceutical Research 19, no. 6 (2020): 1227–32. http://dx.doi.org/10.4314/tjpr.v19i6.17.

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Purpose: To determine the antioxidant and anti-diabetic potential of a natural flavonoid, caffeic acid in a streptozotocin-induced diabetic rat model.Methods: Experimental diabetes was induced in Wistar rats using streptozotocin injection. Caffeic acid was administered orally on daily basis for 5 weeks. A glucometer was used to monitor fasting blood glucose levels. Insulin levels were estimated using enzyme-linked immunosorbent assay (ELISA). The antioxidant potential of caffeic acid was measured by determining the activities of superoxide dismutase (SOD) and catalase (CAT), and levels of redu

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Virgana, Rova, Nur Atik, Julia Windi Gunadi, et al. "MitoTEMPOL Inhibits ROS-Induced Retinal Vascularization Pattern by Modulating Autophagy and Apoptosis in Rat-Injected Streptozotocin Model." Life 12, no. 7 (2022): 1061. http://dx.doi.org/10.3390/life12071061.

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Diabetic retinopathy leads to retinal malfunction, blindness, and reduced quality of life in adult diabetes patients. The involvement of reactive oxygen species (ROS) regulation stimulated by high blood glucose levels opens the opportunity for ROS modulator agents such as MitoTEMPOL. This study aims to explore the effect of MitoTEMPOL on ROS balance that may be correlated with retinal vascularization pattern, autophagy, and apoptosis in a streptozotocin-induced rat model. Four groups of male Wistar rats (i.e., control, TEMPOL (100 mg/kg body weight [BW]), diabetic (streptozotocin, 50 mg/kg BW

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Ghetia, Sawan Mukund, and Chakrakodi Shashidhara Shastry. "VALIDATION OF DIABETES ASSOCIATED DEPRESSION BY STREPTOZOTOCIN INDUCED RAT MODEL." PLANT ARCHIVES 21, Suppliment-1 (2021): 1688–91. http://dx.doi.org/10.51470/plantarchives.2021.v21.s1.266.

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Korish, Aida A., Abdel Galil M. Abdel Gader, and Abdulqader A. Alhaider. "Camel milk ameliorates the coagulopathy in streptozotocin diabetic rat model." International Journal of Dairy Technology 68, no. 1 (2014): 79–87. http://dx.doi.org/10.1111/1471-0307.12168.

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Isken, Tonguc, H. Ege Ozgentas, K. Hakan Gulkesen, and Akif Ciftcioglu. "A Random-Pattern Skin-Flap Model in Streptozotocin Diabetic Rats." Annals of Plastic Surgery 57, no. 3 (2006): 323–29. http://dx.doi.org/10.1097/01.sap.0000221645.92906.5b.

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Chennasamudram, Sudha P., Shashi Kudugunti, Purushotham Reddy Boreddy, Majid Y. Moridani, and Tetyana L. Vasylyeva. "Renoprotective effects of (+)-catechin in streptozotocin-induced diabetic rat model." Nutrition Research 32, no. 5 (2012): 347–56. http://dx.doi.org/10.1016/j.nutres.2012.03.015.

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Hammad, Samar M., Debra J. Hazen-Martin, Mimi Sohn, et al. "Nephropathy in a Hypercholesterolemic Mouse Model with Streptozotocin-Induced Diabetes." Kidney and Blood Pressure Research 26, no. 5-6 (2003): 351–61. http://dx.doi.org/10.1159/000073942.

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Gäbel, H., H. Bitter-Suermann, C. Henriksson, J. Säve-Söderbergh, K. Lundholm, and H. Brynger. "Streptozotocin Diabetes in Juvenile Pigs. Evaluation of an Experimental Model." Hormone and Metabolic Research 17, no. 06 (1985): 275–80. http://dx.doi.org/10.1055/s-2007-1013518.

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Ghasemi, Asghar, S. Khalifi, and S. Jedi. "Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review)." Acta Physiologica Hungarica 101, no. 4 (2014): 408–20. http://dx.doi.org/10.1556/aphysiol.101.2014.4.2.

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Bailey, L. B., A. Molloy, J. Scott, and D. Rice. "Streptozotocin-induced diabetes is not a model for methylmalonic acidaemia." Journal of Inherited Metabolic Disease 12, no. 4 (1989): 429–35. http://dx.doi.org/10.1007/bf01802038.

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Kendra Hosea, Supriyanto Kartodarsono, Arifin, and Sumardi. "Pengaruh Pemberian Produk Olahan Kacang Kedelai Terhadap Glukosa Darah Puasa dan Resistansi Insulin Pada Model Tikus Diabetes Melitus." MEDICINUS 35, no. 3 (2022): 11–16. http://dx.doi.org/10.56951/medicinus.v35i3.102.

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Latar belakang: Diabetes melitus (DM) merupakan kondisi kronis yang memerlukan perawatan medis berkelanjutan serta penanganan dengan strategi multifaktorial. Kacang kedelai diketahui memiliki kandungan isoflavone yang bermanfaat untuk membantu mengendalikan kadar gula darah. Penelitian ini bertujuan untuk mengevaluasi efek pemberian produk olahan kedelai terhadap kadar gula darah puasa dan resistansi insulin. Metode Penelitian: Penelitian ini merupakan penelitian eksperimental dengan subjek penelitian 30 ekor tikus Wistar jantan yang dibagi dalam 5 kelompok, yaitu kelompok tikus normal, kontro

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Yu, Lai-zeng, Xue-peng Zhang, and Ying-xin Wang. "Polygonatum sibiricum extract exerts inhibitory effect on diabetes in a rat model." Tropical Journal of Pharmaceutical Research 18, no. 7 (2021): 1493–97. http://dx.doi.org/10.4314/tjpr.v18i7.19.

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Purpose: To investigate the effect of Polygonatum sibiricum extract (PSE) on streptozotocin-induced diabetic rats. Methods: PSE was obtained by steeping the dried Polygonatum sibiricum in water at 60 oC three times, each for 1 h, before first drying in an oven at 100C and then freeze-drying the final extract, thus obtained. Diabetic model rats were prepared by a single intraperitoneal injection of a freshly prepared solution of streptozotocin (50 mg/kg). The rats were randomly divided into 6 groups of ten rats each: negative control, normal control, reference (glibenclamide1 mg/kg) as we

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Ahmed, Tabrez, Enumula Vinay, Mohammed Abdul Rasheed Naikodi, et al. "Blood Glucose-Lowering Activity of Compound Herbo-Mineral Unani Formulation Qurs-e-Ziabetus in Nicotinamide-Streptozotocin-induced Diabetic Rats." Natural Resources for Human Health 5, no. 1 (2025): 156–70. https://doi.org/10.53365/nrfhh/199578.

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A polyherbal Unani formulation, Qurs-e-Ziabetus (QZ), is mentioned in Unani literature for managing diabetes-like conditions. This study aimed to evaluate the antidiabetic activity of QZ, which is mentioned in classical Unani literature, in nicotinamide-streptozotocin-induced diabetes in Sprague Dawley rats. Preliminary phytochemical screening of QZ and HPTLC fingerprint profile was developed. An oral glucose tolerance test (OGTT) was performed in normal euglycemic SD rats. Further, antihyperglycemic potential was tested in nicotinamide-streptozotocin-induced diabetic rats. Treatment of QZ (25

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A, Aliyu, Nasiru S, Tanko N. D, et al. "Effect of Pre-mixed Extract of Adansonia digitata and Garlic on Streptozotocin (STZ) Induced Hyperglycemic Rat Model." SAR Journal of Medical Biochemistry 3, no. 2 (2022): 7–15. http://dx.doi.org/10.36346/sarjmb.2022.v03i02.001.

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The study investigated the effect of Adansonia digitata and garlic on Blood glucose level in streptozotocin induced diabetic rats. Twenty (20) albino rats were divided into four groups (GI, II, III, and IV) of five rats each and their fasting blood glucose was noted prior to inducement with diabetes using streptozotocin (STZ) at dose of 50mg/kg body weight. GI serves as diabetic control, receives no extract, while GII, GIII and GIV were respectively administered with 500mg/Kg Adansonia digitata extract, 400mg/Kg garlic extract and 500mg/Kg Adansonia – Garlic premix orally for 12 days. The seru

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Chuong, Thi Ngoc Hieu, Quang Thanh Ha, Hoang Minh Nguyen, Minh Thien Trinh, Thanh Chung Mai, and Thi My Duyen Chung. "Anti-hyperglycemic effect of Commelina diffusa extracts on diabetic mice model." Ministry of Science and Technology, Vietnam 66, no. 7 (2024): 28–32. http://dx.doi.org/10.31276/vjst.66(7).28-32.

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This study aimed to investigate the blood glucose stabilising effect of extracts from Commelina diffusa Burm.f. on glucose tolerance test and diabetes test in white mice by streptozotocin. The diabetic mice were induced to hyperglycemia by intraperitoneal injection of streptozotocin in a single dose (170 mg/kg). Water extract, 96% ethanol extract, and 50% ethanol extract of C. diffusa were given orally for 7 days and the reference drug glibenclamide was given orally once on the 7th experimental day. The hypoglycemic effect was evaluated by quantifying fasting plasma glucose concentration and g

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Hira, Sundas, Uzma Saleem, Fareeha Anwar, Muhammad Farhan Sohail, Zohaib Raza та Bashir Ahmad. "β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease". Biomolecules 9, № 9 (2019): 441. http://dx.doi.org/10.3390/biom9090441.

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Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a cascade of changes in cognitive, behavioral, and social activities. Several areas of the brain are involved in the regulation of memory. Of most importance are the amygdala and hippocampus. Antioxidant therapy is used for the palliative treatment of different degenerative diseases like diabetes, cirrhosis, and Parkinson’s, etc. The objective of this study was to assess the effectiveness of exogenous antioxidants, in particular, β carotene (1.02 and 2.05 mg/kg) against intracerebroventricular injected streptozotocin-indu

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Neha, Srivastava. "Pharmacological Screening Of Chrozophora Tinctoria Leaves Extract As Antidiabetic Effect In Rat." International Journal of Medical and Pharmaceutical Research 4, no. 1 (2023): 38–49. https://doi.org/10.5281/zenodo.7502026.

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<strong>Objective: </strong>The present study was carried out to evaluate the pharmacological screening of <em>Chrozophora tinctoria</em> leaves extract as antidiabetic effect in rat. <strong>Method: </strong>The method is used to evaluate pharmacological potential of aqueous leaves extract as antidiabetic effect in rat. In this model, streptozotocin(60mg/kg b.w.) induced rats for one day through intraperitoneal administration, the effect of <em>Chrozophoratinctoria </em>at different dose level that is higher dose (100mg/kg b.w. p.o.) and lower dose (50mg/kg b.w. p.o.). From the study observed

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Rybak, Viktoria, Alexander Honcharov, and Viktoriia Korol. "Study of hypoglycemic properties of «Glyphasonorm» tablets and «Glyphasolin» capsules on the streptozotocin-induced diabetic rat model." ScienceRise: Pharmaceutical Science, no. 6(40) (December 30, 2022): 51–57. http://dx.doi.org/10.15587/2519-4852.2022.271034.

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The risk of developing any complications of diabetes is significantly reduced by monitoring and correcting blood glucose levels and blood pressure, as well as by observing healthy lifestyle rules. Early detection and treatment of type 2 diabetes contribute to the prevention of disease progression and the development of complications. The aim is to study the hypoglycemic effect of «Glyphasonorm» tablets and «Glyphasolin» capsules in a rat model of streptozotocin-induced diabetes. Materials and methods. The studies were carried out on Wistar rats injected intraperitoneally with nicot

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Kirkham, D. M., G. J. Murphy, and P. Young. "Demonstration of inhibitory guanine nucleotide regulatory protein (Gi) function in liver and hepatocyte membranes from streptozotocin-treated rats." Biochemical Journal 284, no. 2 (1992): 301–4. http://dx.doi.org/10.1042/bj2840301.

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By using a defined plasma-membrane preparation, functional inhibition of adenylate cyclase activity by the inhibitory G-protein (Gi) was observed in liver and hepatocyte membranes from rats made diabetic by streptozotocin. These observations contrast with previous reports which have shown a defect in Gi in this diabetic animal model. These results suggest that Gi function is not impaired in the livers of streptozotocin-treated rats and that plasma-membrane preparation procedures should be clearly defined before ascribing Gi defects to a pathological state such as diabetes.

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