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Dissertations / Theses on the topic 'Stress hematopoiesis'

Author: Grafiati

Published: 24 May 2025

Last updated: 31 July 2025

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1

Javier, Jose Emmanuel F. "Increased TGF-beta Signaling Drives Different Hematopoietic Disease Outcomes following Stress Hematopoiesis." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617109578665394.

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2

Büchler-Schäff, Marleen [Verfasser], and Ursula [Akademischer Betreuer] Klingmüller. "Investigation into hematopoietic stem cell function in the context of developmental specification and stress hematopoiesis / Marleen Büchler-Schäff ; Betreuer: Ursula Klingmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1236345436/34.

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3

Sha, Xiaojin. "Translation initiation factor 4E binding protein 1,2 (4E-BP1,2) in hematopoiesis and stress erythropoiesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15797.

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Das Eukaryotische-Initiations faktor-4E Bindungsprotein (4E-BP) ist ein Inhibitor der Translationsinitiation. Nicht-phosphoryliertes 4E-BP bindet an den eukaryotischen Initiationsfaktor 4E (eIF4E). Diese Bindung blockiert die Rekrutierung des Initiationskomplexes eIF4F an die Cap-Struktur des 5´Endes von eukaryotischen zellulären mRNAs, was die Initiation der Translation verhindert. Phosphorylierung von 4E-BP durch die mTOR Kinase führt zur Dissoziation des 4E-BP/eIF4E Komplexes und erhöht die Verfügbarkeit von eIF4E, dies wird mit Zellproliferation assoziiert. Die Aktivität von eIF4E wird nic

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4

Niederkorn, Madeline R. "TIFAB Links Innate Immune Signaling to the Cellular Stress Response in Myeloid Malignancies." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593267529342488.

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5

Sha, Xiaojin [Verfasser], Achim [Gutachter] Leutz, Harald [Gutachter] Saumweber, and Wolfgang [Gutachter] Uckert. "Translation initiation factor 4E binding protein 1,2 (4E-BP1,2) in hematopoiesis and stress erythropoiesis / Xiaojin Sha ; Gutachter: Achim Leutz, Harald Saumweber, Wolfgang Uckert." Berlin : Humboldt-Universität zu Berlin, 2008. http://d-nb.info/1208077198/34.

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6

Traveset, Martínez Laia 1992. "New insights into transcription that preserve hematopoietic stem cell homeostasis." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670105.

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Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding their numbers and increasing the output of blood cells. This dynamic and highly complex process needs to be fully regulated in order to maintain a balance between the differentiation of HSCs and the need to keep a constant pool of HSCs. However, the molecular machinery in charge of this tight regulation has yet to be fully characterized. HSCs represent a small proportion inside

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7

Chiron, Andrada-Silvana. "Investigation into the role of erythropoietin in B cell lymphopoiesis." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5262.

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L'érythropoïétine (EPO) est une hormone produite principalement par les reins, dont la fonction essentielle consiste à assurer l'érythropoïèse. Sa concentration systémique augmente en réponse à l'anémie ou à l'hypoxie. En plus de cette production endogène, l'EPO humaine recombinante est couramment utilisée pour traiter l'anémie des patients atteints d'insuffisance rénale chronique ou de cancer. Les effets immunomodulateurs/immunosuppresseurs de l'EPO sur les lymphocytes matures et plus généralement sur les cellules immunitaires ont été bien étudiés. Cependant, son rôle dans la lympho-hématopoï

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8

McKim, Daniel Boyce. "Neuroimmune and Hematopoietic Regulation of Stress-Induced Anxiety." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492079844476452.

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9

Foltz, Ian Nevin. "Regulation of the stress-activated protein kinase pathways in hematopoietic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ38887.pdf.

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10

OTTOLENGHI, SARA. "ONSET OF ANEMIA IN PULMONARY DISEASES: ROLE OF HYPOXIA, OXIDATIVE STRESS, IRON METABOLISM AND HEMATOPOIETIC REGULATORS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/839664.

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BACKGROUND: In patients affected by severe hypoxia, such as those with Acute Respiratory Distress Syndrome (ARDS), an acute condition characterized by sudden onset of severe hypoxemia and a severe manifestation of COVID19, anemia is a common complication. It remains to be established weather iron metabolism, especially hepcidin, and oxidative stress are involved in negatively interfering with physiological hematopoietic compensatory mechanisms to hypoxia. AIMS: - To investigate etiology and progression of anemia in ARDS patients, through biomarkers of inflammation, iron metabolism and oxidat

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11

Lam, Chi Keung. "The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353098605.

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12

GENOVESE, ELENA. "Ruolo di Calreticulina Wild-Type nell’emopoiesi fisiologica ed effetto delle mutazioni di Calreticulina nello sviluppo delle Neoplasie Mieloproliferative." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1199999.

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Calreticulina (CALR) è uno chaperone da 46 kDa residente nel reticolo endoplasmatico responsabile della regolazione del calcio intracellulare e del folding proteico. CALR è anche in grado di regolare diverse funzioni al di fuori dal reticolo, tra cui la risposta allo stress cellulare. Nel 2013 sono state scoperte diverse mutazioni nell’esone 9 del gene CALR nelle Neoplasie Mieloproliferative (MPNs); in particolare sono state individuate 36 tipi diversi di mutazioni nel 60-70% dei pazienti con Trombocitemia Essenziale (ET) e Mielofibrosi Primaria (PMF) non mutati per JAK2 e MPL. Tali mutazioni

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13

Druce, Megan Claire [Verfasser], and Michael [Akademischer Betreuer] Milsom. "The Impact of Ageing, Replication and Stress on Genome Stability in Hematopoietic Stem Cells / Megan Claire Druce ; Betreuer: Michael Milsom." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1230067191/34.

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14

Meunier, Mathieu. "Evaluation du rôle de la niche hématopoïétique dans l'induction des syndromes myélodysplasiques : rôle de dicer1 et du stress oxydatif." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS014/document.

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Les syndromes myélodysplasiques (SMD) sont dus à une atteinte oligoclonale de la cellule souche hématopoïétique aboutissant à une dysplasie des lignées myéloïdes, des cytopénies sanguines et une évolution fréquente vers la leucémie aiguë. De nombreuses mutations décrites dans des gènes contrôlant la régulation épigénétique sont responsables de la genèse des SMD. Mais des travaux récents montrent également que des anomalies du microenvironnement médullaire, notamment des cellules stromales mésenchymateuses (CSM), peuvent induire et propager un SMD suggérant l’idée d’une communication intercellu

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15

Vandevelde, Amelle. "Rôle de PLZF dans la gestion du stress des cellules souches hématopoïétiques." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0554.

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Les Cellules Souches Hématopoïétiques sont à l’origine de la production de toutes les cellules sanguines et immunitaires, grâce à leur double capacité à s’auto-renouveler et se différencier en progéniteurs puis en cellules matures fonctionnelles. Du fait de leur importance, leur physiologie est contrôlée par de nombreux signaux qui assurent un équilibre entre quiescence, prolifération, auto-renouvellement et différenciation. Mes travaux s’intéressent au rôle du facteur de transcription PLZF dans la régulation des CSH grâce à l’utilisation du modèle murin Zbtb16lu/lu, qui porte une mutation spo

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16

Leveau, Claire. "Ttc7a, un nouveau régulateur de la fonction des cellules souches hématopoïétiques et de la réponse au stress." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2164&f=13489.

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Il est nécessaire au système immunitaire de se développer correctement et de maintenir une balance à l'état basal afin d'être dans des conditions optimales pour répondre à des agressions extérieures. Les mécanismes permettant le maintien de l'homéostasie du système immunitaire ne sont pas encore tout à fait compris. Ttc7a est une protéine peu connue et exprimée de façon ubiquitaire dont l'absence cause d'importantes altérations du système immunitaire à l'état basal dans la souris comme chez l'homme. Dans cette thèse, nous avons cherché à comprendre le rôle de Ttc7a dans le développement et l'h

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17

Zidi, Bochra. "TP53INP1 et PLZF : acteurs du vieillissement dans l’hématopoïèse." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0079.

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Les CSH sont responsables de la production de toutes les cellules sanguines et possèdent une double capacité d'auto-renouvellement et de différenciation en progéniteurs incluant les progéniteurs lymphoïdes B. Étant donné l’importance des CSH, leur physiologie est étroitement contrôlée par une pléthore de signaux qui équilibrent quiescence, prolifération, auto-renouvellement et différenciation. La diminution de la fonction des CSH au cours du vieillissement dépend de plusieurs facteurs intrinsèques et extrinsèques, y compris l’accumulation des ROS au cours du vieillissement. Lorsque les taux de

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18

Queiroz, Julia de Souza 1982. "Atividade moduladora da alga Chlorella vulgaris sobre alterações neuroendócrinas e hematopoéticas causadas pelo estresse." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309859.

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Orientadores: João Palermo Neto, Antonio Armario Garcia<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T19:54:17Z (GMT). No. of bitstreams: 1 Queiroz_JuliadeSouza_D.pdf: 6420413 bytes, checksum: 5de0fbd4bbb6451ff5729cbdc2fc74ce (MD5) Previous issue date: 2012<br>Resumo: A exposição do organismo a estressores psicossociais e ambientais altera de forma significativa o funcionamento do sistema imune. Os efeitos do estresse sobre a resposta imune têm sido atribuídos, principalmente, à ativação do eixo hipotálamo-pit

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19

Camargo, Marilia Alessi Guena de. "Perfil do estresse oxidativo em pacientes com diabetes mellitus do tipo 1 submetidos ao transplante autólogo de células-tronco hematopoéticas, em Ribeirão Preto, SP." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-06012016-151931/.

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O estresse oxidativo, induzido por espécies reativas, está diretamente envolvido com a função das células durante o desenvolvimento do diabetes mellitus do tipo 1 (DM1), bem como no desenrolar das complicações relacionadas à hiperglicemia. O transplante autólogo de células-tronco hematopoéticas é uma estratégia de intervenção imunológica que visa preservar a função do pâncreas endócrino, se realizado durante a fase em que o paciente ainda possui importante reserva de células pancreáticas. Dessa forma, o presente estudo objetiva investigar como o estresse oxidativo se comporta nos momentos pr

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20

Rockenbach, Francieli Juliana. "Adrenoleucodistrofia ligada ao cromossomo x e estresse oxidativo : papel do transplante de células hematopoiéticas e da interleucina 6." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/139389.

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Objetivos. Avaliar o papel do transplante de células hematopoiéticas (TCH) e da interleucina 6 (IL – 6) sobre vários parâmetros de estresse oxidativo em pacientes com Adrenoleucodistrofia ligada ao cromossomo X (X-ALD). Métodos. A concentração de malondialdeído (MDA), o conteúdo de carbolinas e sulfidrilas e a concentração de ácido hexacosanóico (C26:0) foram quantificados no plasma de pacientes X-ALD antes e após serem submetidos ao TCH. E, a concentração de MDA, a formação de carbonilas e a concentração de IL-6 foram quantificados em plasma e o conteúdo de glutationa reduzida (GSH) foi quant

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21

Bossaer, John B., Philip D. Hall, and Eliabeth Garrett-Mayer. "Incidence of Vancomycin-Resistant Enterococci (vre) Infection in High-Risk Febrile Neutropenic Patients Colonized with Vre." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/2315.

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Purpose: This study seeks to determine the incidence of vancomycin-resistant enterococci (VRE) infection in high-risk neutropenic fever patients colonized with VRE and to determine patient characteristics associated with VRE infection. Methods: We conducted a retrospective, single-center, unmatched case-control study. Fifty-three VRE-colonized, high-risk patients with neutropenic fever were identified between January 2006 and February 2009. The two most common diagnoses/conditions included acute myeloid leukemia and hematopoietic stem cell transplantation. Data collected included days of neut

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22

Sha, Xiaojin [Verfasser]. "Translation initiation factor 4E binding protein 1,2 (4E-BP1,2) in hematopoiesis and stress erythropoiesis / Xiaojin Sha." 2008. http://d-nb.info/990397874/34.

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23

Fang, Szu-Wei, and 方思幃. "Proliferation of the hematopoietic cells in common carp head kidney under stress." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/84952913948457436199.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>100<br>The cell and zinc levels in the blood of stressed carp are higher than those of resting carp, at the same time, the cell and zinc levels in head kidney of stressed carp are also higher than those of resting carp. Head kidney is the hematopoietic organ of common carp, the increases of cell level in the blood under stress, may be produced by head kidney. In order to understand how the cells in head kidney of carp proliferate, and the relationship between proliferation and zinc, market carp (stressed carp) and laboratory carp (resting carp) were used as materials

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24

JANE, WU, and 吳沾. "The family stress experience during the period of children undergoing hematopoietic stem cell transplantation." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/08822220644014712594.

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碩士<br>國立台北護理學院<br>護理研究所<br>91<br>The purpose of this study was to understand the family stress experience during the period of children undergoing hematopoietic stem cell transplantation. The study was a qualitative research. A convenient sample was used. By in-depth interview, the real life experience and feelings of the parents during the period of their children undergoing hematopoietic stem cell transplantation was obtained. The cases of this research were parents of the children under 18 years old undergoing hematopoietic stem cell transplantation from a medical center at north Taiwan. Th

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25

Ghosh, Joydeep. "Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia." Diss., 2015. http://hdl.handle.net/1805/9782.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The development and function of hematopoietic stem cells (HSCs) is regulated by numerous signaling pathways including Akt-mechanistic target of rapamycin complex1 (mTORC1) pathway. Dysregulation of this pathway results in impaired HSC function and contributes to the development of hematologic malignancies. Activated mTORC1 phosphorylates and subsequently activates ribosomal protein S6 kinase 1 (S6K1). To study the role of S6K1 in hematopoiesis as well as leukemogenesis, we used a genetic model of S6K1 deficient mice (S6K1-/-). We fou

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26

Lin, Tzu-Yung, and 林子詠. "Effects of stress on zinc concentration in the blood and hematopoietic tissues of common carp Cyprinus carpio and its physiological meaning." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/24387645071613307888.

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博士<br>國立臺灣海洋大學<br>食品科學系<br>100<br>Summary Zinc is an essential nutrient for most organisms. The content of zinc in most tissues of different species is on the order of 10 ~ 100 μg/g wet weight. However, the common carp Cyprinus carpio has high zinc contents in its digestive tract tissue (562 ± 287 μg/g fresh tissue) which is not seen in other fishes. The common carp is able to survive days of anoxia at room temperature and can survive for several months at temperatures between 4 ~ 35℃. In this report, the link between high zinc levels and the extreme stress tolerance of common carp was stu

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27

Φλωράτου, Κωνσταντίνα. "Οξειδωτικό stress και κυτταρικός θάνατος οφειλόμενος σε ακτινοβόληση των CD34+ προγονικών αιμοποιητικών κυττάρων. Προστασία από την παρουσία του IGF-1". Thesis, 2012. http://hdl.handle.net/10889/6246.

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Η ακτινοθεραπεία αποτελεί μέρος της θεραπείας πολλών αιματολογικών κακοηθών νοσημάτων επηρεάζοντας τον αριθμό και την λειτουργικότητα των προγονικών αιμοποιητικών κυττάρων CD34+ Το DNA των κυττάρων αποτελεί το βασικότερο και ίσως καλύτερα μελετημένο μόριο-στόχο της ακτινοβολίας. Ο μηχανισμός που προκαλεί βλάβη στο DNA είναι άμεσος αλλά και έμμεσος. Η άμεση επίδραση και βλάβη της ακτινοβολίας στο DNA αφορά στην απευθείας δράση της στο μόριο του DNA που είναι δυνατόν να οδηγήσει σε αντικατάσταση ή απώλειας μιας βάσης, αλλαγές στην τεταρτοταγή δομή του DNA και κατά συνέπεια στις αλληλεπιδράσεις

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28

Rojas-Sutterlin, Shanti. "Effet du stress prolifératif sur la fonction des cellules souches hématopoïétiques : rôles des gènes Scl, E2A et Heb." Thesis, 2015. http://hdl.handle.net/1866/13528.

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Le système hématopoïétique est un tissu en constant renouvellement et les cellules souches hématopoïétiques (CSHs) sont indispensables pour soutenir la production des cellules matures du sang. Deux fonctions définissent les CSHs; la propriété d’auto-renouvellement, soit la capacité de préserver l’identité cellulaire suivant une division, et la multipotence, le potentiel de différenciation permettant de générer toutes les lignées hématopoïétiques. Chez l’adulte, la majorité des CSHs sont quiescentes et l’altération de cet état corrèle avec une diminution du potentiel de reconstitution des CSHs,

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