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Journal articles on the topic 'Stress induced Hypothyroidism'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Zhang, Xiaohan, Shanshan Shao, Lifang Zhao, et al. "ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism." American Journal of Physiology-Endocrinology and Metabolism 316, no. 3 (2019): E510—E518. http://dx.doi.org/10.1152/ajpendo.00194.2018.

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Recent studies revealed the emerging role of excess uptake of lipids in the development of hypothyroidism. However, the underlying mechanism is largely unknown. We investigated the effect of high-fat diet (HFD) on thyroid function and the role of endoplasmic reticulum (ER) in HFD-induced hypothyroidism. Male Sprague-Dawley rats were fed with HFD or control diet for 18 wk. HFD rats showed an impaired thyroid function, with decreased thyroglobulin (Tg) level. We found the ER stress was triggered in HFD rat thyroid glands and palmitate-treated thyrocytes. Luminal swelling of ER in thyroid epithel

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Yadav, Ashok, and Deepali Soni. "Stress: A Hidden Culprit in Hypothyroidism – A Homeopathic Perspective." International Archives of Integrated Medicine 12, no. 3 (2025): 1–5. https://doi.org/10.5281/zenodo.15101393.

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Hypothyroidism is a prevalent endocrine disorder with multi-factorial causes such as iodine deficiency, autoimmune diseases, and genetic predispositions. However, recent studies suggest that chronic stress may play a pivotal role in the pathogenesis of hypothyroidism. Stress leads to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, altering thyroid function by increasing cortisol levels, suppressing thyroid-stimulating hormone (TSH), and reducing T3 and T4 production. Homeopathy, with its holistic approach, aims to address the root causes of illness, including stress-induced thy

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3

Namdev, Narendra, Gayatri Rai, and Payal Mahobiya. "Alteration in THR?-1 expression on Thyrocytes of Hypothyroidism Mice: Antioxidant Activity of Ashwagandha and Quercetin." Journal of Scientific Research 67, no. 02 (2023): 56–67. http://dx.doi.org/10.37398/jsr.2023.670207.

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:The present study is designed to investigate the protective efficacy of ashwagandha and quercetin against altered THRβ-1 expression, structural damages, and induced oxidative stress in the thyroid gland of hypothyroidism-modeled mice. Mice were orally exposed to cypermethrin for 28 days. The body weight of mice was recorded during the experiment at seven days intervals and the thyroid gland weight was recorded at the end of the experiment after sacrifices. The homogenate of thyroid tissue was prepared for biochemical examinations such as LPO, H SOD, CAT, GSH, GST, GR, and tissues were fixed i

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4

Vyunytska, L. V., T. Yu Yuzvenko, T. I. Dashuk, V. V. Nikonov, V. L. Vasyuk, and N. V. Korotchuk. "Stress-induced urgent conditions in endocrinology." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 20, no. 1 (2024): 68–72. http://dx.doi.org/10.22141/2224-0721.20.1.2024.1360.

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The literature review deals with the influence of chronic stress on the functioning of the endocrine system. The most significant pathological conditions induced by chronic stress are decompensation of carbohydrate metabolism, disorders of the thyroid gland, reproductive system, depressive disorders, electrolyte disorders. The significance of these pathologies is determined by a pronounced decrease in the quality of life, the occurrence of severe complications, and an increase in mortality. The development of hyperglycemia during the acute period of the disease is an established connection bet

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5

Alturfan, A. Ata, E. Zengin, N. Dariyerli, et al. "Investigation of Zinc and Copper Levels in Methimazole-Induced Hypothyroidism: Relation with the Oxidant-Antioxidant Status." Folia Biologica 53, no. 5 (2007): 183–88. https://doi.org/10.14712/fb2007053050183.

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Thyroid hormones are associated with the oxidative and antioxidative status of the organism. Depression of metabolism by hypothyroidism has been reported to decrease oxidant production and thus protect tissues against oxidant damage. The purpose of the present study was to investigate Zn and Cu levels in MMI-induced hypothyroidism and to show whether there is a connection between these trace elements and the oxidant-antioxidant status in experimental hypothyroidism. 3-Nitrotyrosine was measured as a marker of nitro-oxidative stress. In order to examine the antioxidant status of MMI-induced hyp

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6

Hamid, Widad Jumaa. "Oxidative Stress Induced Histological Changes in Thyroid of Hypothyroidism Patients." Al Mustansiriyah Journal of Pharmaceutical Sciences 14, no. 1 (2014): 43–51. http://dx.doi.org/10.32947/ajps.v14i1.126.

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Hypothyroidism is a condition resulting from insufficient production or diminished action of either T3 and/or T4 thyroid hormones.The present study is to look for a correlation between oxidative stress and histological changes of thyroid gland in hypothyroidism patients.30 hypothyroidism patients and 30 healthy individuals as control subjects were included in the study.We measured their serum tri-iodothyronine, thyroxin and thyroid-stimulating hormone (T3, T4, TSH) respectively. Estimation of MalondyIdehyd (MDA) and Glutathione (GSH) in serum and in homogenized thyroid tissue was carried out b

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7

Mukherjee, Sutapa, Luna Samanta, Anita Roy, Shravani Bhanja, and Gagan B. N. Chainy. "Supplementation of T3Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/590897.

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Hypothyroidism is a growing medical concern. There are conflicting reports regarding the mechanism of oxidative stress in hypothyroidism. Mitochondrial oxidative stress is pivotal to thyroid dysfunction. The present study aimed to delineate the effects of hepatic inner mitochondrial membrane dysfunction as a consequence of 6-n-propyl-2-thiouracil-induced hypothyroidism in rats. Increased oxidative stress predominance in the submitochondrial particles (SMP) and altered antioxidant defenses in the mitochondrial matrix fraction correlated with hepatocyte apoptosis. In order to check whether the e

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8

Beheshti, Farimah, Reza Mohebbati, Mahmoud Hosseini, et al. "Effects of vitamin C on cardiovascular oxidative stress induced by hypothyroidism in neonatal and juvenile rats." Future Natural Products 10, no. 1 (2024): 15–21. https://doi.org/10.34172/fnp.183.

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Background and aims: Hypothyroidism and cardiovascular diseases are associated with oxidative stress. Vitamin C is widely recognized for its antioxidant properties. This study aimed to investigate the effects of vitamin C during the neonatal and juvenile periods on oxidative stress induced by hypothyroidism in the hearts of rats. Methods: Sixteen pregnant rats were randomly divided into five groups after delivery: a control group, a group receiving propylthiouracil (PTU), and three treatment groups receiving PTU along with 10, 100, and 500 mg/kg of vitamin C. The experimental treatments contin

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9

Torres-Manzo, Alejandra Paola, Margarita Franco-Colín, Vanessa Blas-Valdivia, Marisol Pineda-Reynoso, and Edgar Cano-Europa. "Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/2089404.

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Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage. Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron. This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE) in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events. Adult Wistar male rats were divided into euthyroid and hypothyroid groups. Thyroidectomy with parathyroid

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10

Brzezińska-Ślebodzińska, Ewa. "Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits." Acta Veterinaria Hungarica 51, no. 3 (2003): 343–51. http://dx.doi.org/10.1556/avet.51.2003.3.9.

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The effect of hypothyroidism on some oxidative stress parameters is reported. Moderate hypothyroid state was induced in two groups of female rabbits (3 and 12 months old) by giving 50 mg/kg body weight (BW) of propylthiouracil (PTU) per os for 6 days and 20 mg/kg BW of methimazole (MMI) for further 14 days. Serum T4 and T3 concentrations decreased by about 38-40 and 32-36%, respectively. The induced hypothyroidism resulted in a significant decrease in the serum concentration of the lipid peroxidation end-product malondialdehyde, as measured by the thiobarbituric-acid assay. Erythrocytes of hyp

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11

Denefil, Olha V., and Sofia M. Charnosh. "Development of oxidative stress in different experimental models of hypothyroidism in immature rats." BULLETIN OF MEDICAL AND BIOLOGICAL RESEARCH 4, no. 1 (2022): 34–38. http://dx.doi.org/10.11603/bmbr.2706-6290.2022.1.12969.

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Summary. Hypothyroidism is one of the common pathologies in the practice of endocrinologist. Autoimmune thyroiditis and alimentary iodine deficiency are the causes of hypothyroidism. Hypothyroidism is especially dangerous in children. An experiment study the pathology of the disease. Today there are several models of experimental hypothyroidism: surgical removal of the thyroid gland or thyrostatics using (thiourea derivatives – propylthiouracil, metamazole, mercazolyl, thyroperoxidase blockers – thiamazole), per os for 1–8 weeks. The aim of the study – to investigate the processes of lipid per

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12

Turner, Isabel, Alyssa A. Smith, Dayeon Jeon, Kaylyn Rudy, Scott Scott Radcliffe, and Alex A. Pasternak. "PSI-3 Induced hypothyroidism causes depressed feed intake and growth in nursery pigs." Journal of Animal Science 103, Supplement_1 (2025): 327–28. https://doi.org/10.1093/jas/skaf102.363.

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Abstract Hypothyroidism has been connected to pathogenic stress in previous research however, the exact role that it plays in reducing body weight and appetite during infection is unknown. Nursery pigs experiencing a polymicrobial disease or Porcine Reproductive and Respiratory Syndrome Virus challenge have lowered triiodothyronine (T3) and thyroxine (T4) concentrations and decreased average daily gain (ADG). We hypothesized that hypothyroidism causes the decreased ADG following pathogenic stress by reducing appetite and altering basal metabolism, leading to decreased feed intake and altered g

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Rodriguez, T. T., W. I. C. Albuquerque-Araújo, L. C. Reis, J. Antunes-Rodrigues, and M. J. Ramalho. "Hypothyroidism Attenuates Stress-Induced Prolactin and Corticosterone Release in Septic Rats." Experimental Physiology 88, no. 6 (2003): 755–60. http://dx.doi.org/10.1113/eph8802621.

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14

Olivares, Emerson L., Cláudio Silva-Almeida, Fernanda M. Pestana, et al. "Social stress-induced hypothyroidism is attenuated by antidepressant treatment in rats." Neuropharmacology 62, no. 1 (2012): 446–56. http://dx.doi.org/10.1016/j.neuropharm.2011.08.035.

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15

Toplan, Selmin, Nuran Dariyerli, Semra Ozdemir, Dervis Ozcelik, Emel U. Zengin, and Mehmet C. Akyolcu. "Lithium-Induced Hypothyroidism: Oxidative Stress and Osmotic Fragility Status in Rats." Biological Trace Element Research 152, no. 3 (2013): 373–78. http://dx.doi.org/10.1007/s12011-013-9629-4.

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16

Santos, Luciano Cardoso, Jeane Martinha dos Anjos Cordeiro, Maria Clara da Silva Galrão Cunha, et al. "Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model." International Journal of Molecular Sciences 25, no. 3 (2024): 1514. http://dx.doi.org/10.3390/ijms25031514.

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Hypothyroidism compromises the testicular redox status and is associated with reduced sperm quality and infertility in men. In this regard, studies have demonstrated the antioxidant potential of kisspeptin in reproductive and metabolic diseases. In this study, we evaluate the effects of kisspeptin-10 (Kp10) on the testicular redox, as well as mediators of the unfolded protein response (UPR) in adult rats with hypothyroidism. Adult male Wistar rats were randomly separated into the Control (n = 15), Hypo (n = 13) and Hypo + Kp10 (n = 14) groups, and hypothyroidism was induced with 6-propyl-2-thi

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Kurhaluk, Natalia, Krzysztof Tota, Małgorzata Dubik-Tota, and Halyna Tkachenko. "LEVEL OF ALDEHYDIC AND KETONIC DERIVATIVES OF OXIDATIVELY MODIFIED PROTEINS IN THE BLOOD OF MEN AND WOMEN WITH MYOCARDIAL INFARCTIONS AND HYPOTHYROIDISM." Biota. Human. Technology, no. 2 (December 29, 2022): 79–91. http://dx.doi.org/10.58407/bht.2.22.6.

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Oxidative stress and excessive reactive oxygen species production play considerable roles in infarction-induced injury impairing cardiac functions, as well as thyroid diseases. Purpose: assessment of the oxidative stress markers, including oxidation of proteins [concentrations of aldehydic and ketonic derivatives of oxidatively modified proteins (OMB)] in the blood of individuals with hypothyroidism and/or myocardial infarction living in the Central Pomerania. Methodology. The level of oxidative stress markers was assessed among 225 individuals, i.e. 132 males (58.67%) and 93 females (41.33%)

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18

Bozbek, ÇK, and M. Şentürk. "Effect of levothyroxine administration on oxidative stress and cytokine levels in rats with experimental hypothyroidism." Journal of the Hellenic Veterinary Medical Society 74, no. 1 (2023): 5227–34. http://dx.doi.org/10.12681/jhvms.28743.

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In this study, it was aimed to determine the effects of levothyroxine (L-T4) administration on serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH) and serum total antioxidant capacity (TAC), serum total oxidant capacity (TOC), oxidative stress index (OSI) and superoxide dismutase (SOD) activity, liver malondialdehyde (MDA) and the effects of cytokines on tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in rats with experimental hypothyroidism. In the study, 48, 39-day-old, male Wistar albino rats were randomly divided into 3 groups cont

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19

Abdul, Mohammed Rashed, Saleh Mohammed Rahim, and Ahmad Hamad Saleh. "Cardioprotective Activity of Costus Root Ethanol Extract in Experimentally-Induced Hypothyroidism in Female Albino Rats." HAYATI Journal of Biosciences 30, no. 6 (2023): 1054–60. http://dx.doi.org/10.4308/hjb.30.6.1054-1060.

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Hypothyroidism is a popular endocrine disorder caused by a thyroid hormone deficit. Changes in the state of the thyroid gland significantly affect many organs, including the heart. This study examined the cardioprotective effects of an artificially induced hypothyroidism in female rats using an ethanol extract from the root plant Saussurea lappa (Costus). For the current study, 25 adult female albino rats were employed. They were split into five equal groups, including control, hypothyroid group, post-treatment group with costus extract, co-administered hypothyroid group with costus extract, a

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20

Idriss, Setana, Mazin Shaikhoun, Srivyshnavi Ramineni, Sheikan Elnigomy, and Margaret Apedo. "A Rare Case of Rhabdomyolysis in a Patient With Pembrolizumab Induced Hypothyroidism." Journal of the Endocrine Society 5, Supplement_1 (2021): A916—A917. http://dx.doi.org/10.1210/jendso/bvab048.1872.

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Abstract Introduction: Although reported in previous literature, Rhabdomyolysis due to hypothyroidism,without an obvious precipitating factor, is rare. We report a case of severe hypothyroidism leading torhabdomyolysis. Case Report: A 70-year-old man with a history of progressive weakness, myalgia x1 month, statinallergy, pancreatic adenocarcinoma, metastatic melanoma, and acquired hypothyroidism afterreceiving Pembrolizumab for 6 months. He was non-adherent to the levothyroxine, prescribed 1month before hospitalization. He presented to the ED after slipping from his bed onto the floor in asea

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Havranova, Jana, Hussam Tayel, Thomas Gallagher, and Mohammad Ishaq Arastu. "Abstract #562 Acute Stress Induced Graves’ Disease in the Setting of Hypothyroidism." Endocrine Practice 25 (April 2019): 286. http://dx.doi.org/10.1016/s1530-891x(20)46906-x.

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Chalouati, H., and L. Payrastre. "Hypothyroidism and liver oxidative stress induced by the fungicide hexachlorobenzene in rats." Toxicology Letters 258 (September 2016): S237. http://dx.doi.org/10.1016/j.toxlet.2016.06.1846.

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Alsayed, Radwa M. "Potential antioxidant & anti-inflammatory protective effect of melatonin receptor agonist in hypo & hyperthyroid rat model." Cuestiones de Fisioterapia 52, no. 1 (2023): 118–30. https://doi.org/10.48047/abcd9595.

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Background: Hormonal instability is linked to inflammation and oxidative stress (OS) through common pathways. Thyroid hormones have been found to play a major part in the antioxidant balance among many hormonal factors, since OS has been linked to both hypothyroidism and hyperthyroidism in humans and animals. A number of research studies have demonstrated the antioxidant, anti-inflammatory, and protective properties of melatonin receptor agonist Ramelteon (RML). Accordingly, the aim of the current study was to examine the potential antioxidant and anti-inflammatory properties of RML on OS indu

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Ayuob, Nasra, Maha Jameal Balgoon, Ahmed A. El-Mansy, Wafaa A. Mubarak, and Alaa El-Din L. Firgany. "Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats." Oxidative Medicine and Cellular Longevity 2020 (July 21, 2020): 1–15. http://dx.doi.org/10.1155/2020/3295831.

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Background. The association between hypothyroidism and renal diseases has been described in many studies. Nigella Sativa was among the recently reported natural product that has the potential to prevent renal tissue damage and fibrosis. The aim of this study was to evaluate the possible protective effect of thymoquinone on the structure of the renal cortex of hypothyroid rats and explore the mechanism behind it. Methods. An experimental model of hypothyroidism was induced in adult male Wistar rats by administration of propylthiouracil (6 mg/kg/body weight). One hypothyroid group was treated wi

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Cano-Europa, Edgar, Vanessa Blas-Valdivia, Gabriel Eduardo Lopez-Galindo, et al. "Methimazole-induced hypothyroidism causes alteration of the REDOX environment, oxidative stress, and hepatic damage; events not caused by hypothyroidism itself." Annals of Hepatology 9, no. 1 (2010): 80–88. http://dx.doi.org/10.1016/s1665-2681(19)31684-9.

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Hegazy, Abdelmonem Awad, Manal Mohammad Morsy, Rania Said Moawad, and Gehad Mohammad Elsayed. "Changes in Adult Rats’ Testis structure Induced by Hypothyroidism and Alleviating Role of L-Carnitine." International Journal of Human Anatomy 1, no. 4 (2019): 13–28. http://dx.doi.org/10.14302/issn.2577-2279.ijha-19-3026.

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Background Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidative stress. L-carnitine (LC) regulates long chain fatty acids metabolism; and is considered a valuable antioxidant factor. Aim It was to evaluate the effect of hypothyroidism induced by propylthiouracil (PTU) on rats’ testes and the possible protective role of LC. Methods Forty-eight adult male albino rats were used in this work. The animal

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Zamoner, Ariane, Kátia Padilha Barreto, Danilo Wilhelm Filho, et al. "Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis." Journal of Molecular Endocrinology 40, no. 3 (2008): 125–35. http://dx.doi.org/10.1677/jme-07-0089.

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Congenital hypothyroidism was induced in rats by adding 0.05% 6-propyl-2-thiouracil in the drinking water from day 9 of gestation, and continually up to postnatal day 15. Structural alterations observed by light microscopy of seminiferous tubules and by transmission electron microscopy of Sertoli cells of treated animals were consistent with hypothyroid condition. Hypothyroidism was also associated with high phospho-p38 mitogen-activated protein kinase and decreased phospho-extracellular signal-regulated kinase 1/2 levels. Furthermore, the phosphorylation and the immunoreactivity of cytoskelet

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Shahid Shakeel, Saif ur Rehman, Sadia Kazi, Saadia Zainab, Moazna Talpur, and Abro Fatima Qazi. "Unveiling Oxidative Stress Dynamics: A Comparative Study of Biochemical and Anti-Oxidative Parameters in Thyroid Dysfunction." Journal of Saidu Medical College, Swat 14, no. 4 (2024): 400–404. http://dx.doi.org/10.52206/jsmc.2024.14.4.998.

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Background: The prevalence of thyroid dysfunction is significant, and its association with oxidative stress and biochemical changes is well recognized. Thyroid hormones are crucial in maintaining oxidative balance and regulating the body's metabolic processes to protect against cellular damage.Objectives: The study aimed to compare biochemical and oxidative stress parameters in rat models of hypothyroidism and hyperthyroidism.Materials and Methods: This research, conducted from September 14 to October 21, 2023, involved 21 male Wistar divided into hypothyroid (n=7), hyperthyroid (n=7), and con

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Sabatino, Laura, Rudina Ndreu, and Cristina Vassalle. "Oxidative stress and heart disease: the thyroid hormone mediation." Vessel Plus 5 (2021): 3. http://dx.doi.org/10.20517/2574-1209.2020.62.

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The heart is one of the principal targets of thyroid hormones (TH) action, affecting cardiac contractility, heart rate, and diastolic function. Oxidative damage is pivotal for onset and development of cardiovascular disease (CVD) and heart failure. Specifically, free radical generation is associated to hyper-metabolic state in hyperthyroidism, whereas hypo-metabolic state induced by hypothyroidism leads to a decrease of oxidative stress. In the present review, the role of oxidative damage in CVD and failing heart-TH interplay will be considered. The main oxidative events leading to cardiac dys

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Кondratiuk, V. E., and А. P. Stakhova. "Thyroid gland and heart: a cardiologist’s view on an endocrinological pathology. Review." Clinical Endocrinology and Endocrine Surgery, no. 3 (September 30, 2023): 41–50. http://dx.doi.org/10.30978/cees-2023-3-41.

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The review of the literature considered the mechanism of action and the role of thyroid hormones (TH) on cardiovascular hemodynamics and, subsequently, on changes in the myocardial structure. A brief description of the genomic and non‑genomic mechanisms of thyroid hormones is provided. The mechanisms of thyroid hormones’ effects on the development of arterial and pulmonary hypertension, atrial fibrillation are highlighted. Attention is focused on the fact that congestive heart failure of the dilatation type develops against the background of hyperthyroidism. A possible connection between thyro

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Hedayati, M., S. Niazmand, M. Hosseini, Y. Baghcheghi, F. Beheshti, and S. Niazmand. "Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats." Endocrine Regulations 51, no. 4 (2017): 205–12. http://dx.doi.org/10.1515/enr-2017-0021.

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Abstract Objectives. The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks.

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Harms, Craig A., James J. Hoskinson, David S. Bruyette, et al. "Development of an experimental model of hypothyroidism in cockatiels (Nymphicus hollandicus)." American Journal of Veterinary Research 55, no. 3 (1994): 399–404. http://dx.doi.org/10.2460/ajvr.1994.55.03.399.

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Summary Hypothyroidism is 2 possible predisposing factor in a number of disorders of companion psittacine birds. We developed and validated a thyroid-stimulating hormone (tsh) response testing protocol for cockatiels (Nymphicus hollandicus), using 0.1 IU of tsh/bird given IM, with blood sample collection at 0 and 6 hours after tsh, and a commercial radioimmunoassay for thyroxine (T4). This protocol was used to document a seasonal sex difference in stimulated T4 values— females responded with higher T4 values than those in males in summer—and a stress-induced depression of baseline T4 values wa

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AYGÜN, Kemal, Ozden GOKDEMIR, Ali Rıza ŞİŞMAN, and Tevfik DEMİR. "The Relationship Between Hypothyroidism-Induced Autoantibodies, TSH Levels, and RDW, as an Inflammation Marker." Cukurova Anestezi ve Cerrahi Bilimler Dergisi 6, no. 1 (2023): 56–66. http://dx.doi.org/10.36516/jocass.1210920.

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Aim: Serum RDW grades were detected in patients with Hashimoto's thyroiditis. We aimed to use RDW to detect increased cardiovascular events in patients, increased oxidative stress, and inflammation without the need for an additional cost. Methods: We collected 904 persons results, 462 patients which have Hashimoto's thyroiditis, and 442 age and sex-matched control cases were comprised in our study. From laboratory measurements of the patients’ records were utilized such as hemogram, hs-CRP, fasting blood glucose, insulin, C-peptide, kidney function tests, liver function tests (ALT, AST), serum

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Tanase, Daniela Maria, Evelina Maria Gosav, Ecaterina Neculae, et al. "Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options." International Journal of Molecular Sciences 21, no. 16 (2020): 5927. http://dx.doi.org/10.3390/ijms21165927.

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Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide problem and its association with other metabolic pathologies has been one of the main research topics in the last decade. The aim of this review article is to provide an up-to-date correlation between hypothyroidism and NAFLD. We followed evidence regarding epidemiological impact, immunopathogenesis, thyroid hormone-liver axis, lipid and cholesterol metabolism, insulin resistance, oxidative stress, and inflammation. After evaluating the influence of thyroid hormone imbalance on liver structure and function, the latest studies ha

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Yoo, Dae Young, Hyo Young Jung, Hyun Jung Kwon, et al. "Effects of Dendropanax morbifera Léveille extract on hypothyroidism-induced oxidative stress in the rat hippocampus." Food Science and Biotechnology 25, no. 6 (2016): 1761–66. http://dx.doi.org/10.1007/s10068-016-0268-3.

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Al_Musawi, Alaa Saeed Abdullah, and Sabreen Majeed Mohamed Ali. "Curcumin nanoparticles attenuate propylthiouracil (PTU) mediated hepatotoxicity in male rats via activation of catalase function." International Journal of Environmental Sciences 11, no. 12s (2025): 854–62. https://doi.org/10.64252/27wcf925.

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Background: Hypothyroidism and Hepatotoxicity are damage to the liver which can occur, for example, due to propylthiouracil (PTU) induced oxidative stress. It could be assumed that natural antioxidants such as curcumin and its nano-formulations like Curcumin-Chitosan nanoparticles (Cur-Cs-NPs) might be protective in this condition. Aims: To evaluate the protective role of Cur-Cs-NPs against PTU-induced hypothyroidism and hepatotoxicity in male Wistar rats by assessing biochemical, molecular, and histological parameters. Methods: Fifty-five adult male Wistar rats used, with fifteen in the preli

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Kit, O. I., E. M. Frantsiyants, V. A. Bandovkina, et al. "Changes in the functional activity of the hypothalamic-pituitaryadrenal axis in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism." CARDIOMETRY, no. 27 (May 4, 2023): 40–46. http://dx.doi.org/10.18137/cardiometry.2023.27.4046.

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The hypothalamic-pituitary-adrenal axis (HPA) makes the body’s response to various stress factors, interacting with the thyroid and gonadal axis. The aim of our work was to study the effect by induced hypothyroidism on changes in the functioning of the HPA axis in rats with Guerin’s carcinoma of both sexes. Materials and methods. The experiment was performed in white outbred rats of both sexes. Hypothyroidism was induced in animals by medication for 30 days with Mercazolil, and then Guerin’s carcinoma was transplanted (the main group). The reference groups covered animals with the independent

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Chang, X.-R., Y.-L. Yao, D. Wang, et al. "Influence of hypothyroidism on testicular mitochondrial oxidative stress by activating the p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase signaling pathways in rats." Human & Experimental Toxicology 38, no. 1 (2018): 95–105. http://dx.doi.org/10.1177/0960327118781927.

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Thyroid hormone deficiency can impair testicular function. However, knowledge of the effects of mitogen-activated protein kinase (MAPK) pathways on testicular mitochondrial oxidative damage induced by hypothyroidism is still rudimentary. This study aims to explore the possible mechanisms of testicular mitochondrial oxidative damage in hypothyroidism rats. Wistar male rats were randomly divided into control (C), low- (L), and high-hypothyroidism (H) groups (1 ml/100 g body weights (BWs)/day 0, 0.001% and 0.1% propylthiouracil, respectively) by intragastric gavage for 60 days. Blood samples were

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Vita, Roberto, Valeria Cernaro, and Salvatore Benvenga. "Stress-induced hashitoxicosis: case report and relative HLA serotype and genotype." Revista da Associação Médica Brasileira 65, no. 6 (2019): 830–33. http://dx.doi.org/10.1590/1806-9282.65.6.830.

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SUMMARY OBJECTIVE Even though stress has been long known as a provocative factor for Graves’ disease, its relationship with Hashimoto's thyroiditis is more controversial. Studies on this topic are scanty. This paper aims to report a case of stress-induced Hashitoxicosis. RESULTS Here we report a case of Hashitoxicosis induced by a psychological stressful event in a 28-year-old woman with Hashimoto's thyroiditis. She had remained stably euthyroid for 12 years. She was first observed in April 2016, while euthyroid. She came back after 11 months because of fatigue and palpitations, in the absence

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Alzoubi, K. H., A. M. Aleisa, and K. A. Alkadhi. "Effect of chronic stress or nicotine on hypothyroidism–induced enhancement of LTD: Electrophysiological and molecular studies." Neurobiology of Disease 32, no. 1 (2008): 81–87. http://dx.doi.org/10.1016/j.nbd.2008.06.008.

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Rastogi, Leena, Madan M. Godbole, Madhur Ray, et al. "Reduction in oxidative stress and cell death explains hypothyroidism induced neuroprotection subsequent to ischemia/reperfusion insult." Experimental Neurology 200, no. 2 (2006): 290–300. http://dx.doi.org/10.1016/j.expneurol.2006.02.013.

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Chuhray, Svetlana N., Viktoria E. Lavrynenko, Rostyslav F. Kaminsky, et al. "CARDIOVASCULAR SYSTEM OF THE MATURE RATS WITH CONGENITAL HYPOTHYROIDISM AND ARTERIAL HYPERTENSION." Wiadomości Lekarskie 73, no. 10 (2020): 2209–13. http://dx.doi.org/10.36740/wlek202010119.

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The aim: Studying changes in the ultrastructure of blood circulatory capillaries of the myocardium of mature rats with hypothyroidism and arterial hypertension. Materials and methods: Experiments were conducted on (240 days) 10 ISIAH (inherited stress-induced arterial hypertension) line rats with AH (arterial hypertension), 10 Wistar line rats with congenital hypothyroidism and 10 intact animals. Arterial pressure was measured, and the development of hypothyroidism was controlled by the immune enzyme method. The study of the left ventricle myocardium of the rat heart was carried out by electro

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Zhang, Pei, Min Yang, Li Zeng, and Changjiang Liu. "P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats." Cellular Physiology and Biochemistry 45, no. 4 (2018): 1303–15. http://dx.doi.org/10.1159/000487558.

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Background/Aims: Triclosan, as an antimicrobial agent and a potential endocrine disruptor, has been used extensively in diverse products, resulting in widespread human exposure. In recent years, studies suggest that triclosan could disturb thyroid functions and decline thyroid hormones (THs). Methods: To verify our hypothesis that the MAPK pathway may function significantly in triclosan-induced hypothyroidism, Sprague-Dawley rats were gavaged with triclosan for 31 consecutive days; Nthy-ori 3-1 cells were treated with triclosan in the presence/absence of NAC, inhibitors (SB203580 and SB202474)

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Depke, Maren, Gerhard Fusch, Grazyna Domanska, et al. "Hypermetabolic Syndrome as a Consequence of Repeated Psychological Stress in Mice." Endocrinology 149, no. 6 (2008): 2714–23. http://dx.doi.org/10.1210/en.2008-0038.

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Stress is a powerful modulator of neuroendocrine, behavioral, and immunological functions. After 4.5-d repeated combined acoustic and restraint stress as a murine model of chronic psychological stress, severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced alterations of metabolic processes that were found in a hepatic mRNA expression profiling were verified by in vivo analyses. Repeatedly stressed mice developed a hypermetabolic syndrome with the severe loss of lean body mass, hyperglycemia, dyslipidemia, increased amino acid turnover, and acidosis. This was a

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Blerina, Asllanaj, Sheikhan Nazanin, Trad George, and Darmal Sean. "Amiodarone induced myxedema coma presenting with cardiogenic shock and junctional rhythm." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 352–55. https://doi.org/10.5281/zenodo.8379923.

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We describe the case of an elderly female, with no prior history of thyroid dysfunction, who presented with facial swelling and worsening fatigue. She was found to have myxedema coma, with thyroid-stimulating hormone (TSH) 98.90 uIU/mL and free thyroxine (fT4) 0.8 ng/dL, following two months of amiodarone therapy for paroxysmal atrial fibrillation. The patient developed cardiogenic shock and received liothyronine, levothyroxine, stress dose steroids, inotropic and vasopressor therapy while in the intensive care unit (ICU). She was weaned off vasopressors and switched to oral levothyroxine with

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Abdel-Reheim, E. S., and S. M. Abd El-Twab. "Effect of Carrot Oil Supplementation on Oxidative Stress in Experimentally-Induced Hypothyroidism and Hyperthyroidism in Albino Rats." Egyptian Journal of Zoology 62 (December 2014): 229–54. http://dx.doi.org/10.12816/0009345.

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Venditti, P., M. Balestrieri, S. Di Meo, and T. De Leo. "Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues." Journal of Endocrinology 155, no. 1 (1997): 151–57. http://dx.doi.org/10.1677/joe.0.1550151.

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The effects of altered thyroid states on lipid peroxidation, antioxidant capacity, and susceptibility to oxidative stress of rat tissues were examined. Hypothyroidism was induced by administering methimazole in drinking water for 15 days. Hyperthyroidism was elicited by a 10-day treatment of hypothyroid rats with tri-iodothyronine (10 micrograms/100 g body weight). In tissues of hypothyroid rats the lipid peroxidation was not modified, whereas in hyperthyroid rats lipid peroxidation increased in liver and heart but not in skeletal muscle. The glutathione peroxidase activity increased significa

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Hussein, Abd El-Aziz M., Amr M. Abbas, Gehan A. El Wakil, Ayman Z. Elsamanoudy, and Azza Abd El Aziz. "Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats." Canadian Journal of Physiology and Pharmacology 90, no. 5 (2012): 617–25. http://dx.doi.org/10.1139/y2012-046.

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Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 μg/L) for 8 weeks. Serum thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), thyroid antioxidants (catalase, superoxide dismutase enzymes, and total antioxidants), and lipid peroxide (malondialdehyde; MDA) were measured. Reverse transcription – PCR gene expression for thyroidal

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Fyfe-Desmarais, Guillaume, Fréderik Desmarais, Éric Rassart, and Catherine Mounier. "Apolipoprotein D in Oxidative Stress and Inflammation." Antioxidants 12, no. 5 (2023): 1027. http://dx.doi.org/10.3390/antiox12051027.

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Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is upregulated in a number of pathologies, including Alzheimer’s disease, Parkinson’s disease, cancer, and hypothyroidism. Upregulation of ApoD is linked to decreased oxidative stress and inflammation in several models, including humans, mice, Drosophila melanogaster and plants. Studies suggest that the mechanism through which ApoD modulates oxidative stress and regulate inflammation is via its capacity to bind arachidonic acid (ARA). This polyunsaturated omega-6 fatty acid can be metabolised to generate large

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Abdullina, Guzel Maratovna, Feliks Khusainovich Kamilov, Valerii Nikolaevich Kozlov, et al. "Comparative Analysis of Oxidative Metabolism in Liver in Different Experimental Models of Hypothyroidism: Low Iodine Diet and Anti-Thyroid drug (Methimazole)." Biomedical and Pharmacology Journal 17, no. 3 (2024): 1963–73. http://dx.doi.org/10.13005/bpj/2998.

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Objectives: On the concept of oxidative stress in hypothyroidism, which still remains ambiguous and controversial, the article emphasizes the issue of the impact of the experimental conditions on the validity of the data obtained in different methods of modeling thyroid dysfunction. Materials and Methods: Experiments were conducted on 112 white nonlinear male rats. Thyroid hormones and biomarkers of oxidative metabolism in the liver tissue were determined in rats kept for 3 months on a low-iodine diet (LID) and in rats with methimazole (MMI)-induced hypothyroidism (2,5 mg/100 g of body weight

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