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1

(Firm), Bristol-Myers Squibb. Stroke: A learning and resource guide. Bristol-Myers Squibb Oncology, 1999.

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2

Dock, Daniel P. A false claim: Stroke from manipulation. D.P. Dock, 1994.

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3

1946-, Feuerstein Giora Z., ed. Inflammation and stroke. Birkhäuser, 2001.

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4

Culebras, A. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013.

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5

Zoppo, Gregory J. Del. Innate inflammation and stroke. Edited by New York Academy of Sciences. Published by Blackwell Pub. on behalf of the New York Academy of Sciences, 2010.

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6

R, Caplan Louis, and Bogousslavsky Julien, eds. Uncommon causes of stroke. 2nd ed. Cambridge University Press, 2008.

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7

Kensey, Kenneth R. The blood thinner cure: A revolutionary seven-step lifestyle plan for stopping heart disease and stroke. Contemporary Books, 2001.

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8

Huckabee, Maggie Lee, and Stephanie K. Daniels. Dysphagia Following Stroke. Plural Publishing Inc, 2008.

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9

Daniels, Stephanie K., and Maggie-Lee Huckabee. Dysphagia Following Stroke. Plural Publishing, Incorporated, 2019.

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10

Zhang, John H., and Yang V. Li. Metal Ion in Stroke. Springer, 2012.

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11

Zhang, John H., and Yang V. Li. Metal Ion in Stroke. Springer New York, 2016.

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12

Metal Ion In Stroke. Springer, 2012.

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13

Zhang, John H., and Yang V. Li. Metal Ion in Stroke. Springer, 2012.

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14

Thrombus and stroke. Informa Healthcare, 2008.

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15

Linfante, Italo, Ajay K. Wakhloo, Matthew J. Gounis, Baruch B. Lieber, and Robert A. Mericle. Thrombus and Stroke. Taylor & Francis Group, 2008.

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16

Linfante, Italo, Ajay K. Wakhloo, Matthew J. Gounis, Baruch B. Lieber, and Robert A. Mericle. Thrombus and Stroke. Taylor & Francis Group, 2008.

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17

Baltan, Selva, S. Thomas Carmichael, and Carlos Matute. White Matter Injury in Stroke and CNS Disease. Springer, 2013.

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18

(Editor), Julien Bogousslavsky, and Louis Caplan (Editor), eds. Uncommon Causes of Stroke. Cambridge University Press, 2008.

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19

Arsovska, Anita. Rare Causes of Stroke. Edited by Derya Uluduz. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781108902793.

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Stroke is the second leading cause of death and major cause of long-term disability, directly impacting the quality of life, worldwide. Strokes with more rare, and unknown causes unfortunately receive little to no attention due to the heterogeneity of disorders and a poor understanding of clinical features. There are considerable variations in the etiology of this rare sub-category of stroke; requiring heightened clinical awareness for recognition, evaluation and treatment. This book provides up-to-date guidance, through case reports concisely summarised by global leaders in the field describi
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20

Dodds, Jodi, Aaron I. Loochtan, and Cheryl D. Bushnell. Ischemic Stroke Management in Pregnancy. Edited by Emma Ciafaloni, Cheryl Bushnell, and Loralei L. Thornburg. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0014.

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Ischemic stroke during pregnancy is relatively rare, but when it occurs, the risk is highest in the postpartum period. This is a condition that requires immediate recognition and evaluation for acute management to potentially prevent devastating neurological consequences. Determining an etiology while considering physiological changes during and after pregnancy is also important. Post-stroke care including implementing secondary stroke prevention via pharmacological and non-pharmacological methods is regular practice. Consideration of physical, occupational, and speech therapy strategies as we
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21

Zhang, John H., Selva Baltan, S. Thomas Carmichael, Carlos Matute, and Guohua Xi. White Matter Injury in Stroke and CNS Disease. Springer London, Limited, 2013.

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22

White Matter Injury In Stroke And Cns Disease. Springer-Verlag New York Inc., 2013.

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23

Baltan, Selva, S. Thomas Carmichael, Carlos Matute, Guohua Xi, and John H. Zhang. White Matter Injury in Stroke and CNS Disease. Springer, 2016.

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24

Ringer, Andrew. Surgical and Radiologic Intervention for Prevention of Ischemic Stroke. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0104.

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The etiology of ischemic strokes can be broadly categorized into several subtypes: cardioembolic, extracranial atherosclerotic, intracranial atherosclerotic, lacunar, traumatic (e.g., dissections), inflammatory (e.g., Moyamoya, vasculitis), and last cryptogenic. This chapter focuses on those etiologies that are treated or prevented by cerebrovascular specialist, including strokes due to extracranial athero-occlusive disease, intracranial athero-occlusive disease, arterial dissections, and Moyamoya disease. Both medical and surgical approaches are discussed.
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25

Mohr, J. P., Issam D. Moussa, and Tatjana Rundek. Asymptomatic Carotid Artery Stenosis: A Primer on Risk Stratification and Management. Taylor & Francis Group, 2007.

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26

(Editor), Issam Moussa, Tatjana Rundek (Editor), and Jay Preston Mohr (Editor), eds. Asymptomatic Carotid Artery Stenosis: A Primer on Risk Stratification and Management. Informa Healthcare, 2007.

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27

Turkington, Carol A., and Kenneth R. Kensey M. D. The Blood Thinner Cure : A Revolutionary Seven-Step Lifestyle Plan for Stopping Heart Disease and Stroke. McGraw-Hill, 2001.

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28

Chong, Ji Y., and Michael P. Lerario. A Horner’s Syndrome Following Trauma. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190495541.003.0017.

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Carotid dissection should be considered as a stroke etiology, especially in young patients with a history of trauma. Carotid dissection can be recognized by exam findings and radiographic studies. Treatment can include aspirin or anticoagulation.
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29

Chong, Ji Y., and Michael P. Lerario. Puff of Smoke. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190495541.003.0023.

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Moyamoya is a rare cause of stroke caused by progressive distal carotid occlusion. Children and adults may be affected, but it is more common in Asian populations, particularly in patients presenting with intracranial hemorrhage. Angiographic findings of distal internal carotid artery stenosis with lenticulostriate or choroidal neocollaterals are important in the diagnosis of moyamoya disease. A similar pathophysiological state to moyamoya disease is associated with several clinical conditions, some of which are acquired and some of which have a genetic etiology. Treatment is with surgical rev
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30

Goeral, Katharina, Ali Fatemi, and Michael V. Johnston. Neonatal Brain Injuries. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0072.

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Neonatal brain injuries (NBIs) are important causes of motor and neurocognitive disabilities in children worldwide. This chapter discusses the most common types of NBIs in developed countries, namely neonatal encephalopathy associated with birth asphyxia in term infants, perinatal arterial ischemic stroke, perinatal white matter injury, and germinal matrix hemorrhage and neonatal hydrocephalus. Epidemiologic studies suggest that prenatal stressors, including intrauterine inflammation, maternal drug/toxin exposure, and placental pathologies are key players in the etiology of NBIs, whereas genet
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31

Kelly, Thomas J., and Mijail Serruya. Integrative Approaches to Cognitive Decline. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0017.

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The ability to remember, plan, communicate, and multitask changes with normal, healthy aging. These cognitive abilities decline more rapidly and with greater severity in the setting of neurodegenerative disease. The most common etiology of neurodegenerative cognitive decline is Alzheimer’s disease, and other processes, such as those triggered by stroke, dementia with Lewy bodies, and traumatic brain injury, also cause significant debility. The purpose of this chapter is to review evidence-based integrative medical interventions that may slow both normal and disease-related cognitive decline in
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32

Shaibani, Aziz. Pseudoneurologic Syndromes. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199898152.003.0022.

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The word “functional” has rightly replaced the word “psychogenic” in the medical literature to describe disorders for which no organic etiology is found. Pseudoseizures, tremors, weakness and numbnessare the most common functional neurological disorders. It takes experience and knowledge of the patterns of presentation of neuromuscular disorders and some understanding of the common functional disorders in order to diagnose the latter correctly and early enough to avoid unnecessary investigations. Some genuine neuromuscular disorders such as myasthenia gravis, small fiber neuropathy, and chroni
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33

Richiardi, Lorenzo, Giovenale Moirano, and Pagona Lagiou. Testicular Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0021.

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Testicular cancer is highly curable and, though relatively rare, it is the most common cancer among young men. Incidence of testicular cancer has been increasing constantly around the world since the beginning of the twentieth century, but factors responsible for the rise in incidence remain enigmatic. Only few risk factors for testicular cancer are established, including age, ethnic group, cryptorchidism and hypospadias, contralateral testicular cancer, family history, and height. While analytic epidemiologic research has provided numerous etiologic clues, many of them remain tentative. Overw
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34

Chong, Ji Y., and Michael P. Lerario. Hypertension and Confusion. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190495541.003.0025.

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Posterior reversible encephalopathy syndrome is a clinical–radiographic syndrome of progressive headaches, blurred vision, confusion, and seizures in the setting of vasogenic edema on brain imaging, which is often localized to the posterior white matter. The symptoms are classically triggered by severe hypertension, pregnancy and the puerperium, or exposure to immunosuppressive medications. The symptoms can be reversible if the offending etiology is quickly removed, but permanent deficits can remain if strokes or hemorrhage complicate the clinical course.
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35

Amin, Sandeep. Cervical Facet Dysfunction. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0005.

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Cervical facet dysfunction poses a diagnostic and therapeutic dilemma in patients with axial neck pain due to either degenerative changes or whiplash injuries as it presents with a paucity of diagnostic radiologic or examination findings. The specific orientation of the cervical facet joints renders them particularly vulnerable to whiplash injury. This chapter examines the clinically relevant anatomy with nuances unique to the cervical spine, etiology of the structural changes, diagnostic tools, and treatment of cervical facet dysfunction. Understanding the relevant anatomy and referral patter
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36

Mirabello, Lisa, Rochelle E. Curtis, and Sharon A. Savage. Bone Cancers. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0042.

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Cancers arising from bone or cartilage account for about 0.2% of malignant neoplasms. They are histologically heterogeneous with multiple rare subtypes. Osteosarcoma and Ewing sarcoma occur primarily in children and young adults, whereas other bone cancers occur in older individuals. As a group, bone cancers have few known environmental risk factors, the exception being a strong association between therapeutic radiation and increased risk of osteosarcoma. The genetic etiology is also better understood in osteosarcoma, although there have been limited studies in other types of bone cancers. Thi
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37

García-Cazorla, Angels, and Rafael Artuch. Brain Serotonin Deficiency. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0032.

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Brain serotonin deficiency is a heterogeneous condition whose etiology remains unknown in the majority of cases. Strong evidence supports a major role for brain serotonin deficiency in common conditions such as depression and other psychiatric and cognitive disorders, which are probably due to interactions between genetic and environmental factors. Mendelian monogenic conditions leading to brain serotonin deficiency have also been identified, but they are rare. These diseases are associated with defects in other neurotransmitters (primarily dopamine), and it is difficult to link serotonin defi
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38

Sousek, Alexandra, and Mehdi Tafti. The genetics of sleep. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0005.

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Although there is strong evidence for a genetic contribution to inter-individual variations in sleep, the underlying factors and their interaction remain largely elusive. Much effort has been expended in studying genetic variations contributing to circadian and sleep phenotypes, the individual pattern of the human sleep EEG, reactions to sleep loss, and the pathophysiology of sleep-related disorders. Certain sleep-related diseases may be caused by single genes, while the etiology of others seems to be variable and complex. This is especially the case when the immune system is involved. This ch
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39

Cassin, Stephanie E., and Neil A. Rector. Psychological Models of Obsessive Compulsive and Spectrum Disorders. Edited by Gail Steketee. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376210.013.0041.

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The current chapter provides an overview of psychoanalytic and behavioral theories of obsessive compulsive disorder and related conditions (i.e., hoarding, hypochondriasis, body dysmorphic disorder, trichotillomania, and tic disorders), and reviews the empirical support for these psychological theories. While Freud correctly ascribed compulsive rituals to an anxiety-reducing role, the more fundamental tenets of his drive model of obsessional development, and the subsequent focus on the role of defense mechanisms, have remained largely untested. In contrast, behavioral theories of obsessive com
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40

Brink, Johann, and Todd Tomita. Psychotic disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199360574.003.0033.

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The presentation of psychotic disorders in jails and prisons can be quite complex and diverse. In addition to the schizophrenia spectrum disorders, there are the many disorders of unclear etiology or secondary to the neurotoxic effects of substance abuse. In parallel, the provision of empirically informed care for incarcerated offenders with psychotic disorders presents significant clinical, security, and administrative challenges. However, strong scientific evidence exists that a configuration of interventions offers substantial benefit in the treatment of incarcerated individuals with psycho
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41

Brink, Johann, and Todd Tomita. Psychotic disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199360574.003.0033_update_001.

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The presentation of psychotic disorders in jails and prisons can be quite complex and diverse. In addition to the schizophrenia spectrum disorders, there are the many disorders of unclear etiology or secondary to the neurotoxic effects of substance abuse. In parallel, the provision of empirically informed care for incarcerated offenders with psychotic disorders presents significant clinical, security, and administrative challenges. However, strong scientific evidence exists that a configuration of interventions offers substantial benefit in the treatment of incarcerated individuals with psycho
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42

Tangen, Catherine M., Marian L. Neuhouser, and Janet L. Stanford. Prostate Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0053.

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Prostate cancer is the most common solid tumor and the second leading cause of cancer-related mortality in American men. Worldwide, prostate cancer ranks second and fifth as a cause of cancer and cancer deaths, respectively. Despite the international burden of disease due to prostate cancer, its etiology is unclear in most cases. Established risk factors include age, race/ancestry, and family history of the disease. Prostate cancer has a strong heritable component, and genome-wide association studies have identified over 110 common risk-associated genetic variants. Family-based sequencing stud
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43

Hjalgrim, Henrik, Mads Melbye, and Pagona Lagiou. Hodgkin Lymphoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0026.

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The descriptive epidemiology of Hodgkin lymphoma (HL) has demonstrated marked variation by age, sex, social class, and time, strongly suggesting both a role of environmental factors and the existence of etiologically diverse HL subtypes. There is increasing evidence that Epstein Barr virus (EBV)–positive and EBV-negative classical HLs define two variants with separate etiologies. The risk for both increases with family history, whereas immune dysfunction and infectious mononucleosis have been implicated in EBV-positive HL risk only. Despite being the less common of the two, the natural history
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44

Kaplan, Stuart L., ed. Your Child Does Not Have Bipolar Disorder. ABC-CLIO, LLC, 2011. http://dx.doi.org/10.5040/9798216040057.

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An eminent child psychiatrist provides an insider's, whistle-blowing perspective on the promotion of a diagnostic entity that does not exist. Your Child Does Not Have Bipolar Disorder: How Bad Science and Good Public Relations Created the Diagnosis examines this diagnostic fad through a variety of lenses. Author Stuart L. Kaplan, MD, draws heavily on his forty years of experience as a clinician, researcher, and professor of child psychiatry to make the argument that bipolar disorder in children and adolescents is incorrectly diagnosed and incorrectly treated. As Dr. Kaplan explains, the dramat
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45

Shaibani, Aziz. Pseudoneurologic Syndromes. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190661304.003.0022.

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The term functional has almost replaced psychogenic in the neuromuscular literature for two reasons. It implies a disturbance of function, not structural damage; therefore, it defies laboratory testing such as MRIS, electromyography (EMG), and nerve conduction study (NCS). It is convenient to draw a parallel to the patients between migraine and brain tumors, as both cause headache, but brain MRI is negative in the former without minimizing the suffering of the patient. It is a “software” and not a “hardware” problem. It avoids irritating the patient by misunderstanding the word psychogenic whi
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