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Journal articles on the topic 'Stromal tissue'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Cha, Yoon Jin, and Ja Seung Koo. "Expression of Autotaxin–Lysophosphatidate Signaling-Related Proteins in Breast Cancer with Adipose Stroma." International Journal of Molecular Sciences 20, no. 9 (2019): 2102. http://dx.doi.org/10.3390/ijms20092102.

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This research aimed to evaluate the expression and clinical implication of autotaxin (ATX)-lysophosphatidate (LPA) signaling-related proteins in breast cancer with adipose stroma. To this end, a tissue microarray (TMA) was constructed from 137 breast cancer tissues with adipose stroma and 329 breast cancer tissues with non-adipose stroma (inflammatory stroma: n = 81, 24.6%; fibrous stroma: n = 246, 75.4%). Immunohistochemical staining for ATX-LPA signaling-related proteins (ATX, LPA1, LPA2, and LPA3) was performed on the TMA. The results showed that LPA2 in tumor cells and LPA3 in stromal cell

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Kondo, Fukuo. "Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma." International Journal of Hepatology 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/241652.

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Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 imm

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Fernández-Nogueira, Patricia, Mario Mancino, Gemma Fuster, et al. "Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy." Journal of Clinical Medicine 9, no. 3 (2020): 776. http://dx.doi.org/10.3390/jcm9030776.

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Current evidences state clear that both normal development of breast tissue as well as its malignant progression need many-sided local and systemic communications between epithelial cells and stromal components. During development, the stroma, through remarkably regulated contextual signals, affects the fate of the different mammary cells regarding their specification and differentiation. Likewise, the stroma can generate tumour environments that facilitate the neoplastic growth of the breast carcinoma. Mammographic density has been described as a risk factor in the development of breast cance

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Li, Shengjun, Jeong-Bin Park, and Hyung-Jun Im. "Abstract 5007: Discovery of stromal targets in pancreatic cancer." Cancer Research 82, no. 12_Supplement (2022): 5007. http://dx.doi.org/10.1158/1538-7445.am2022-5007.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with limited treatment options. Development of stroma targeting therapeutics for PDAC is gaining attention because PDAC has a unique tumor microenvironment with dense tumor stroma and the tumor stroma is a critical mediator of PDAC progression. Herein, we discovered pancreatic cancer stroma-specific cell surface markers by integrative analysis of single cell RNA sequencing and cell surface marker database. Methods: Single cell RNA sequencing data of PDAC tissue (n = 3, GSE154778) and normal panc

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Rujchanarong, Denys, Julia Lefler, Janet E. Saunders, et al. "Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry." Cancers 13, no. 17 (2021): 4419. http://dx.doi.org/10.3390/cancers13174419.

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Breast stroma plays a significant role in breast cancer risk and progression yet remains poorly understood. In breast stroma, collagen is the most abundantly expressed protein and its increased deposition and alignment contributes to progression and poor prognosis. Collagen post-translation modifications such as hydroxylated-proline (HYP) control deposition and stromal organization. The clinical relevance of collagen HYP site modifications in cancer processes remains undefined due to technical issues accessing collagen from formalin-fixed, paraffin-embedded (FFPE) tissues. We previously develo

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Wu, Dongling, Sean Hacking, and Yihong Wang. "Abstract P1-09-11: Machine Learning based analysis in chemotherapy resistant triple negative breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–09–11—P1–09–11. https://doi.org/10.1158/1557-3265.sabcs24-p1-09-11.

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Abstract Background: Chemotherapy resistances were believed to be caused by tumor cell DNA alterations; However, recent years’ tumor micro-environment (TME) study has increasingly revealed the complementary interactions between tumor cells and peri, intratumoral stromal cells and inflammatory cells. The role of TME in acquired chemoresistance has yet been fully understood.With the development of bioinformatics, the analysis of TME has expanded to a more "micro" molecular level: through ssGSEA analysis, the gene expression differences between normal tissue and peri, intratumoral tissue were abl

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Boivin, Felix J., та Darren Bridgewater. "β-Catenin in stromal progenitors controls medullary stromal development". American Journal of Physiology-Renal Physiology 314, № 6 (2018): F1177—F1187. http://dx.doi.org/10.1152/ajprenal.00282.2017.

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The renal stroma is a population of matrix-producing fibroblast cells that serves as a structural framework for the kidney parenchyma. The stroma also regulates branching morphogenesis and nephrogenesis. In the mature kidney, the stroma forms at least three distinct cell populations: the capsular, cortical, and medullary stroma. These distinct stromal populations have important functions in kidney development, maintenance of kidney function, and disease progression. However, the development, differentiation, and maintenance of the distinct stroma populations are not well defined. Using a mouse

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8

Chang, H., N. Mohabir, S. Done, and P. A. Hamel. "Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer." Journal of Clinical Pathology 62, no. 10 (2009): 908–14. http://dx.doi.org/10.1136/jcp.2009.067298.

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Background:Loss of the stromally-restricted homeodomain transcription factor, Alx4, causes defective mouse mammary epithelial morphogenesis.Aims:To begin to define the role of ALX4 in the human breast and in breast cancer, the expression pattern of ALX4 in the normal human breast and changes in expression in breast cancer were determined.Methods:Cells expressing ALX4 in the human breast were identified by co-immunofluorescence using α-ALX4 antibodies and markers of specific mammary cell types. ALX4 expression in breast cancer was then determined by immunohistochemistry on tumour sections that

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9

Osidak, Egor Olegovich, Andrey Yurevich Andreev, Sergey Eduardovich Avetisov, et al. "Corneal Stroma Regeneration with Collagen-Based Hydrogel as an Artificial Stroma Equivalent: A Comprehensive In Vivo Study." Polymers 14, no. 19 (2022): 4017. http://dx.doi.org/10.3390/polym14194017.

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Restoring the anatomical and functional characteristics of the cornea using various biomaterials is especially relevant in the context of a global shortage of donor tissue. Such biomaterials must be biocompatible, strong, and transparent. Here, we report a Viscoll collagen membrane with mechanical and optical properties suitable for replacing damaged stromal tissue. After removing a portion of the stroma, a Viscoll collagen membrane was implanted into the corneas of rabbits. After 6 months, the active migration of host cells into Viscoll collagen membranes was noted, with the preservation of c

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Feng, Qiu-Shi, Xiao-Feng Shan, Vicky Yau, Zhi-Gang Cai, and Shang Xie. "Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method." Pharmaceuticals 18, no. 1 (2025): 62. https://doi.org/10.3390/ph18010062.

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Background: Tumors, as intricate ecosystems, comprise oncocytes and the highly dynamic tumor stroma. Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and progression, through its interactions with biological, chemical, and mechanical signals. This review aims to analyze the challenges of stroma mimicry models, and highlight advanced personalized co-culture approaches for recapitulating tumor stroma using patient-derived tumor organoids (PDTOs). Methods: This review synthesizes findings from recent

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Genovese, Luca, and Andrea Brendolan. "Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8419104.

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Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal strom

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Zhou, Jiong, Takashi Suzuki, Agnes Kovacic, et al. "Interactions between Prostaglandin E2, Liver Receptor Homologue-1, and Aromatase in Breast Cancer." Cancer Research 65, no. 2 (2005): 657–63. http://dx.doi.org/10.1158/0008-5472.657.65.2.

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Abstract Local synthesis of estrogens within breast adipose tissue by cytochrome P450 aromatase contributes to the growth of postmenopausal breast cancers. One of the major stimulators of aromatase expression in breast is prostaglandin E2 (PGE2) derived from tumorous epithelium and/or infiltrating macrophages. Recently, the orphan nuclear receptor, liver receptor homologue-1 (LRH-1), has also been shown to regulate aromatase expression in breast adipose tissue. We therefore examined the expression of, and correlations between, aromatase and LRH-1 mRNA in a panel of breast carcinoma tissues and

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Klimczak, Aleksandra, and Urszula Kozlowska. "Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/4285215.

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Multipotent mesenchymal stromal/stem cells (MSCs) reside in many human organs and comprise heterogeneous population of cells with self-renewal ability. These cells can be isolated from different tissues, and their morphology, immunophenotype, and differentiation potential are dependent on their tissue of origin. Each organ contains specific population of stromal cells which maintain regeneration process of the tissue where they reside, but some of them have much more wide plasticity and differentiate into multiple cells lineage. MSCs isolated from adult human tissues are ideal candidates for t

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Leonard, Brian C., Krista Cosert, Moritz Winkler, et al. "Stromal Collagen Arrangement Correlates with Stiffness of the Canine Cornea." Bioengineering 7, no. 1 (2019): 4. http://dx.doi.org/10.3390/bioengineering7010004.

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The cornea is the most external layer of the eye and serves two important roles in (1) the refraction of light and (2) protection from the outside environment, both of which are highly dependent on the collagen assembly of the corneal stroma. This study sought to determine the collagen fiber arrangement of the canine corneal stroma and correlate the stromal organization with tissue stiffness in the anterior and posterior cornea. Collagen organization of the canine cornea was visualized through second-harmonic generation (SHG) imaging, and tissue stiffness of the anterior and posterior corneal

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15

Kitano, Haruhisa, Shun-Ichiro Kageyama, Stephen M. Hewitt, et al. "Podoplanin Expression in Cancerous Stroma Induces Lymphangiogenesis and Predicts Lymphatic Spread and Patient Survival." Archives of Pathology & Laboratory Medicine 134, no. 10 (2010): 1520–27. http://dx.doi.org/10.5858/2009-0114-oa.1.

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Abstract Context.—Podoplanin is a mucin-type glycoprotein and a lymphatic endothelial marker. Immunohistochemical staining for podoplanin is currently used as a routine pathologic diagnosis tool in Japan to identify lymphatic invasion of cancer cells. Recent reports suggest that podoplanin and other proangiogenic molecules are expressed in stromal fibroblasts and myofibroblasts. Objective.—To analyze the distribution of podoplanin expression in tumor stroma and its clinical and biologic significance. Design.—We performed immunohistochemistry for podoplanin on tissue microarrays from 1350 cases

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Richardson, A., A. Player, Y. Wang, et al. "Potential targets in prostate tumor–associated stroma." Journal of Clinical Oncology 25, no. 18_suppl (2007): 15529. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15529.

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15529 Background: The past 20 years have seen a shift in the paradigm that the stromal compartment in tissues is merely a passive, supporting tissue for epithelial cells. Recent evidence shows that it plays a critical role not only in normal tissue development and homeostasis, but also in the progression of cancer. Further, as the stromal compartment is more readily accessible to vascular-delivered agents, this region might be particularly amenable to clinical intervention. As such, a broad-based study of the carcinoma-associated changes in stromal cells from patient samples could yield a weal

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Suda, Kazuaki, Hirofumi Nakaoka, Kosuke Yoshihara, et al. "Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium." Human Reproduction 34, no. 10 (2019): 1899–905. http://dx.doi.org/10.1093/humrep/dez155.

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Abstract STUDY QUESTION Are there common mutation profiles between epithelial and stromal cells in ovarian endometriotic tissue and the normal endometrium? SUMMARY ANSWER Our study revealed no common mutations between epithelial and stromal cells in ovarian endometriotic tissue and the normal endometrium. WHAT IS KNOWN ALREADY Epithelial cells in both ovarian endometriotic tissue and the normal endometrium harbor somatic mutations in cancer-associated genes such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and KRAS proto-oncogene, GTPase (KRAS). STUDY DESI

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Risbridger, Gail P., and Renea A. Taylor. "Regulation of Prostatic Stem Cells by Stromal Niche in Health and Disease." Endocrinology 149, no. 9 (2008): 4303–6. http://dx.doi.org/10.1210/en.2008-0465.

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The isolation and characterization of prostatic stem cells has received significant attention in the last few years based on the belief that aberrant regulation of adult stem cells leads to prostate disease including cancer. The nature of the perturbations in stem cell regulation remains largely unknown. Although adult stem cells are can be governed by autonomous regulatory mechanisms, the stromal niche environment also provides essential cues to direct directing differentiation decisions and can lead to aberrant proliferation and/or differentiation. Elegant tissue recombination experiments, p

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Petrov, S. B. "Stromal fibroblasts and invasive cancer growth." Kazan medical journal 69, no. 3 (1988): 220–21. http://dx.doi.org/10.17816/kazmj98464.

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Stromal fibroblasts from 230 cancerous tumors of different localization were studied. Fibroblasts were located in the stroma of cancerous tumors relatively uniformly - on average 2430.9 133.7 per 1 mm2 stroma, but since the stroma occupied only a part of tumors, the number of fibroblasts per 1 mm2 histological preparation of neoplasm was somewhat lower and varied from 58.1 to 2772.0 (on average 1114.4 107.8), and in some cases fibroblasts were the prevailing cell type. The axial orientation of these stromal cells, especially in the areas of mature stroma, mostly coincided with the direction of

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Wiesen, J. F., P. Young, Z. Werb, and G. R. Cunha. "Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development." Development 126, no. 2 (1999): 335–44. http://dx.doi.org/10.1242/dev.126.2.335.

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Stromal-epithelial interactions are critical in determining patterns of growth, development and ductal morphogenesis in the mammary gland, and their perturbations are significant components of tumorigenesis. Growth factors such as epidermal growth factor (EGF) contribute to these reciprocal stromal-epithelial interactions. To determine the role of signaling through the EGF receptor (EGFR) in mammary ductal growth and branching, we used mice with a targeted null mutation in the Egfr. Because Egfr−/− mice die perinatally, transplantation methods were used to study these processes. When we transp

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Maltseva, M. F., A. A. Pishchulin, and M. E. Bronstein. "Stromal ovarian tecomatosis." Problems of Endocrinology 42, no. 3 (1996): 40–45. http://dx.doi.org/10.14341/probl12046.

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In 1942, S. Geist and J. Geines were the first to publish the unusual results of a histological examination of ovarian tissue in patients with Stein-Leventhal syndrome. They found foci of "luteinized" tecal cells, similar to theca interna folliculi cells, scattered along the ovarian "stroma" outside the follicles. The following year, L. Fraenkel in his work called these histopathological changes in ovarian hypertosis. In 1949, A. Culiner and S. Shipel used the term "hypertension syndrome" to refer to conditions in which foci of "tekomatosis", consisting of 10-30-60 individual hypertrophic and

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Plava, Jana, Marina Cihova, Monika Burikova, et al. "Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy." Cells 9, no. 2 (2020): 480. http://dx.doi.org/10.3390/cells9020480.

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During cancer progression, breast tumor cells interact with adjacent adipose tissue, which has been shown to be engaged in cancer aggressiveness. However, the tumor-directed changes in adipose tissue-resident stromal cells affected by the tumor–stroma communication are still poorly understood. The acquired changes might remain in the tissue even after tumor removal and may contribute to tumor relapse. We investigated functional properties (migratory capacity, expression and secretion profile) of mesenchymal stromal cells isolated from healthy (n = 9) and tumor-distant breast adipose tissue (n

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Bentaleb, M., N. Taouri, R. EL Hachimi, R. El Hadiri, and Lalla Ouafa Cherkaoui. "AN UNSUAL VIRAL ENDOTHELIITIS." International Journal of Advanced Research 9, no. 12 (2021): 478–79. http://dx.doi.org/10.21474/ijar01/13933.

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HSV infection can affect nearly every ocular tissue. In cases of corneal involvement, the epithelium, stroma, or endothelium may be affected. Both herpes stromal keratitis (HSK) and HSV endotheliitis can present clinically with stromal opacity and, therefore, may be difficult to distinguish. In this case we will be describing a viral endotheliitis with a particular aspect on the corneal endothelium.

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Goehrig, Delphine, Jérémy Nigri, Rémi Samain та ін. "Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer". Gut 68, № 4 (2018): 693–707. http://dx.doi.org/10.1136/gutjnl-2018-317570.

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ObjectivePancreatic cancer is associated with an abundant stromal reaction leading to immune escape and tumour growth. This massive stroma drives the immune escape in the tumour. We aimed to study the impact of βig-h3 stromal protein in the modulation of the antitumoural immune response in pancreatic cancer.DesignWe performed studies with p48-Cre;KrasG12D, pdx1-Cre;KrasG12D;Ink4a/Arffl/fl, pdx1-Cre;KrasG12D; p53R172H mice and tumour tissues from patients with pancreatic ductal adenocarcinoma (PDA). Some transgenic mice were given injections of anti-βig-h3, anti-CD8, anti-PD1 depleting antibodi

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Cheng, Xi, Steven J. Petsche, and Peter M. Pinsky. "A structural model for the in vivo human cornea including collagen-swelling interaction." Journal of The Royal Society Interface 12, no. 109 (2015): 20150241. http://dx.doi.org/10.1098/rsif.2015.0241.

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A structural model of the in vivo cornea, which accounts for tissue swelling behaviour, for the three-dimensional organization of stromal fibres and for collagen-swelling interaction, is proposed. Modelled as a binary electrolyte gel in thermodynamic equilibrium, the stromal electrostatic free energy is based on the mean-field approximation. To account for active endothelial ionic transport in the in vivo cornea, which modulates osmotic pressure and hydration, stromal mobile ions are shown to satisfy a modified Boltzmann distribution. The elasticity of the stromal collagen network is modelled

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Verma, Aruna, and Pankhudi Srivastava. "Ossified ovarian fibroma-a rare entity." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 12 (2024): 3748–50. http://dx.doi.org/10.18203/2320-1770.ijrcog20243617.

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Ovarian fibroma are sex cord stromal tumors of pure stromal variety; they originate from excessive growth of the stroma and connective tissue of the cortex of the ovary. As per the available literature, incidence of ovarian fibromas accompanied by further ossification are quite uncommon. Our study's goal is to offer a rare instance that has been appropriately recognized and treated, together with a depiction of the pathogenic mechanisms behind it.

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Barclay, Wendy W., Ralph D. Woodruff, M. Craig Hall, and Scott D. Cramer. "A System for Studying Epithelial-Stromal Interactions Reveals Distinct Inductive Abilities of Stromal Cells from Benign Prostatic Hyperplasia and Prostate Cancer." Endocrinology 146, no. 1 (2005): 13–18. http://dx.doi.org/10.1210/en.2004-1123.

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The development of normal and abnormal glandular structures in the prostate is controlled at the endocrine and paracrine levels by reciprocal interactions between epithelium and stroma. To study these processes, it is useful to have an efficient method of tissue acquisition for reproducible isolation of cells from defined histologies. Here we assessed the utility of a standardized system for acquisition and growth of prostatic cells from different regions of the prostate with different pathologies, and we compared the abilities of stromal cells from normal peripheral zone, benign prostatic hyp

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Souza da Silva, Ricella M., Eduardo M. Queiroga, Alexandre R. Paz, Fabiana F. P. Neves, Karin S. Cunha, and Eliane P. Dias. "Standardized Assessment of the Tumor-Stroma Ratio in Colorectal Cancer: Interobserver Validation and Reproducibility of a Potential Prognostic Factor." Clinical Pathology 14 (January 2021): 2632010X2198968. http://dx.doi.org/10.1177/2632010x21989686.

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The tumor stroma plays a relevant role in the initiation and evolution of solid tumors. Tumor-stroma ratio (TSR) is a histological feature that expresses the proportion of the stromal component that surrounds cancer cells. In different studies, the TSR represents a potential prognostic factor: a rich stroma in tumor tissue can promote invasion and aggressiveness. The aim of this study was to evaluate the reproducibility and determine the interobserver agreement in the TSR score. The stromal estimate was evaluated in patients diagnosed with colorectal adenocarcinoma (CRA), who underwent surgica

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Kokkaliaris, Konstantinos D., and David T. Scadden. "Cell interactions in the bone marrow microenvironment affecting myeloid malignancies." Blood Advances 4, no. 15 (2020): 3795–803. http://dx.doi.org/10.1182/bloodadvances.2020002127.

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Abstract The bone marrow is a complex tissue in which heterogeneous populations of stromal cells interact with hematopoietic cells to dynamically respond to organismal needs in defense, hemostasis, and oxygen delivery. Physiologic challenges modify stromal/hematopoietic cell interactions to generate changes in blood cell production. When either stroma or hematopoietic cells are impaired, the system distorts. The distortions associated with myeloid malignancy are reviewed here and may provide opportunities for therapeutic intervention.

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Thomas, Rintu, John Michael Jerome, Kimiko L. Krieger, Naghmana Ashraf, and David R. Rowley. "The reactive stroma response regulates the immune landscape in prostate cancer." Journal of Translational Genetics and Genomics 8, no. 3 (2024): 249–77. http://dx.doi.org/10.20517/jtgg.2024.15.

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Prostate cancer remains the most commonly diagnosed and the second leading cause of cancer-related deaths in men in the United States. The neoplastic transformation of prostate epithelia, concomitant with modulations in the stromal compartment, known as reactive stromal response, is critical for the growth, development, and progression of prostate cancer. Reactive stroma typifies an emergent response to disrupted tissue homeostasis commonly observed in wound repair and pathological conditions such as cancer. Despite the significance of reactive stroma in prostate cancer pathobiology, our under

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Maurer, Carlo, Sam R. Holmstrom, Jing He, et al. "Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes." Gut 68, no. 6 (2019): 1034–43. http://dx.doi.org/10.1136/gutjnl-2018-317706.

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ObjectivePancreatic ductal adenocarcinoma (PDA) has among the highest stromal fractions of any cancer and this has complicated attempts at expression-based molecular classification. The goal of this work is to profile purified samples of human PDA epithelium and stroma and examine their respective contributions to gene expression in bulk PDA samples.DesignWe used laser capture microdissection (LCM) and RNA sequencing to profile the expression of 60 matched pairs of human PDA malignant epithelium and stroma samples. We then used these data to train a computational model that allowed us to infer

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Lim, S. M. L., I. Aksoy, K. G. C. Lim, et al. "Re-establishing pluripotency in adult cells derived from breast stromal tissue." Journal of Clinical Oncology 29, no. 27_suppl (2011): 227. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.227.

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227 Background: Recent advances in pluripotent stem cell biology offer patient-specific disease models to investigate in vitro mechanisms of tumorigenesis. Induced pluripotent stem (iPS) cells were originally derived by reprogramming of human dermal fibroblasts through ectopic expression of pluripotency–associated transcription factors. A limitation to the use of dermal fibroblasts as the starting cell type for reprogramming is that it usually takes weeks to expand cells from a single biopsy, and the efficiency of the process is very low. In contrast, a large number of adipose-derived mesenchy

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Najdawi, Fedaa, Sandhya Srinivasan, Neel Patel, et al. "Abstract 5447: Artificial intelligence (AI)-based classification of stromal subtypes reveals associations between stromal composition and prognosis in NSCLC." Cancer Research 83, no. 7_Supplement (2023): 5447. http://dx.doi.org/10.1158/1538-7445.am2023-5447.

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Abstract Background: Many cancers are known to involve a desmoplastic stromal reaction. While cancer-associated stroma (CAS) has long been appreciated histologically, single-cell molecular analyses have revealed its heterogeneity, and the cellular composition of CAS has been linked to prognosis in several cancer types, including NSCLC. While pathologists have sought to manually classify CAS based on collagen architecture or nuclear density, this approach has not sufficiently captured the heterogeneity of CAS. To this end, we have developed an artificial intelligence (AI)-based model to predict

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Petrella, Francesco, Isabella Rimoldi, Stefania Rizzo, and Lorenzo Spaggiari. "Mesenchymal Stromal Cells for Antineoplastic Drug Loading and Delivery." Medicines 4, no. 4 (2017): 87. http://dx.doi.org/10.3390/medicines4040087.

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Mesenchymal stromal cells are a population of undifferentiated multipotent adult cells possessing extensive self-renewal properties and the potential to differentiate into a variety of mesenchymal lineage cells. They express broad anti-inflammatory and immunomodulatory activity on the immune system and after transplantation can interact with the surrounding microenvironment, promoting tissue healing and regeneration. For this reason, mesenchymal stromal cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Another clinical application of mesenchymal s

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Singer, C. F., D. Gschwantler-Kaulich, A. Fink-Retter, et al. "Differential gene expression profile in breast cancer-derived stromal fibroblasts." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21075. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21075.

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21075 Background: Breast cancer is chatacterized by malignant transformation of epithelial cells, but stromal cells also play an important role in tumorigenesis. While tumoral fibroblasts display unique phenotypical properties, it is unclear whether they also represent are a specific subpopulation. Materials and Methods: Stromal fibroblasts deriving from malignant tissue of 10 women with invasive breast cancer, and from normal breast tissue of 10 women with benign breast disorders, were subjected to differential complementary DNA Microarray Analysis by using a 2400 gene cDNA array. Gene expres

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Santra, Mithun, Yu-Chi Liu, Vishal Jhanji, and Gary Hin-Fai Yam. "Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives." International Journal of Molecular Sciences 23, no. 14 (2022): 7967. http://dx.doi.org/10.3390/ijms23147967.

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A transparent cornea is paramount for vision. Corneal opacity is one of the leading causes of blindness. Although conventional corneal transplantation has been successful in recovering patients’ vision, the outcomes are challenged by a global lack of donor tissue availability. Bioengineered corneal tissues are gaining momentum as a new source for corneal wound healing and scar management. Extracellular matrix (ECM)-scaffold-based engineering offers a new perspective on corneal regenerative medicine. Ultrathin stromal laminar tissues obtained from lenticule-based refractive correction procedure

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Jain, Neha, Vishwa Shah, and Vikas Mittal. "Descemet Stripping endothelial keratoplasty donor graft dissection following bowman-stromal Inlay preparation." Indian Journal of Ophthalmology - Case Reports 4, no. 2 (2024): 441–44. http://dx.doi.org/10.4103/ijo.ijo_2343_23.

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This article outlines the dissection of donor grafts in descemet’s stripping endothelial keratoplasty (DSEK) after Bowman–Stromal inlay (BSI) tissue preparation. Following the femtosecond (FS) laser-assisted BSI for stromal augmentation in keratoconus, the donor cornea is transitioned to an artificial anterior chamber. The dissection of the DSEK graft is meticulously performed using blunt dissectors, considering the varying tissue thickness (thinner at the center and gradually thickening toward the periphery). This approach was successfully employed in three corneal donor tissues, facilitating

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Filipovski, Vanja, Katerina Kubelka-Sabit, Dzengis Jasar, Gligor Dimitrov, and Vesna Janevska. "Reactive Stroma in Prostatic Carcinoma and Correlation with Tumor Grade and Tumor Stage." Macedonian Medical Review 71, no. 2 (2017): 123–27. http://dx.doi.org/10.1515/mmr-2017-0021.

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Abstract Introduction. Reactive stroma co-evolves with prostatic carcinoma. The aim of this study is to establish stromal changes in the prostatic cancer tissue and to quantify those changes. Methods. Samples from 70 patients treated with radical prostatectomy due to prostatic cancer were used for this analysis. Stromal changes in prostatic cancer tissue were analyzed using histochemical stain Trichrome Masson and immunohistochemical stains Vimentin and Desmin and those changes were compared to the stromal composition in the surrounding benign prostatic hyperplasia. These changes were quantifi

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Gerstenberger, Wladimir, Michaela Wrage, Eeva Kettunen, et al. "Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases." Analytical Cellular Pathology 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8651790.

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The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of 161 primary tumor samples. 50.7% of squamous cell lung cancer (SCC) tumors showed strong expression of

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Gottschling, S., R. Kuner, M. Granzow, et al. "The individuality of tumor-stroma interaction in non-small cell lung cancer: Insights from functional and molecular analyses." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11115. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11115.

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11115 Background: Tumor-stroma interaction plays a significant role for malignant growth. Results from prostate and breast cancer rodent models show cancerogenic properties of tumor-associated and genetically altered stromal cells (SC) when combined with initiated or normal epithelium (Olumi et al., Cancer Res 1999, Kuperwasser et al., PNAS 2004). However, data on the mechanisms and sequels of tumor-stroma interaction in lung cancer are scanty. Methods: Here, we analyzed the functional and molecular sequels of cross-talk between the non-small cell lung cancer (NSCLC) cell lines A549, H23, and

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Hong, Mun-Kun, Jen-Hung Wang, Cheng-Chuan Su, Ming-Hsun Li, Yung-Hsiang Hsu, and Tang-Yuan Chu. "Expression of Estrogen and Progesterone Receptor in Tumor Stroma Predicts Favorable Prognosis of Cervical Squamous Cell Carcinoma." International Journal of Gynecologic Cancer 27, no. 6 (2017): 1247–55. http://dx.doi.org/10.1097/igc.0000000000001004.

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ObjectivesThe aim of this study was to investigate the expression of estrogen receptor α (ERα) and progesterone receptor B (PRB) in the stroma and carcinoma tissues of cervical cancer and their relationship to clinical characteristics and the status of human papillomavirus (HPV) infection.MethodsExpressional levels of ERα and PRB in tissue blocks of 95 cervical carcinomas were independently scored by 2 pathologists. Human papillomavirus DNA, viral load, and genotypes were determined by polymerase chain reaction. Clinical characteristics were reviewed from chart and cancer registry.ResultsEstro

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McKay, Tina B., Dimitrios Karamichos, Audrey E. K. Hutcheon, Xiaoqing Guo, and James D. Zieske. "Corneal Epithelial–Stromal Fibroblast Constructs to Study Cell–Cell Communication in Vitro." Bioengineering 6, no. 4 (2019): 110. http://dx.doi.org/10.3390/bioengineering6040110.

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Cell–cell communication plays a fundamental role in mediating corneal wound healing following injury or infection. Depending on the severity of the wound, regeneration of the cornea and the propensity for scar development are influenced by the acute resolution of the pro-fibrotic response mediated by closure of the wound via cellular and tissue contraction. Damage of the corneal epithelium, basement membrane, and anterior stroma following a superficial keratectomy is known to lead to significant provisional matrix deposition, including secretion of fibronectin and thrombospondin-1, as well as

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Kim, Hye Min, Yu Kyung Lee, and Ja Seung Koo. "Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor." Disease Markers 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/4218989.

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Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT).Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFRα/β, and NG2) and analyzed the results according to clinicopathologic parameters.Results. Expression of PDGFRαand PDGFRβin the stromal component increased with increasing histologic gr

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Girard, M. T., M. Matsubara, C. Kublin, M. J. Tessier, C. Cintron, and M. E. Fini. "Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling." Journal of Cell Science 104, no. 4 (1993): 1001–11. http://dx.doi.org/10.1242/jcs.104.4.1001.

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The process of connective tissue remodeling is an important mechanism contributing to tissue morphogenesis in development and homeostasis. Although it has long been known that remodeling tissues actively mediate collagenolysis, little is understood about the molecular mechanisms controlling this cell-regulated process. In this study, we examined the biosynthesis of collagenase and the related metalloproteinase, stromelysin, during remodeling of repair tissue deposited after mechanical injury to the rabbit cornea. Neither enzyme was synthesized by uninjured corneas; however, synthesis and secre

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Yoshimine, Toshiki, Yukitaka Ushio, Toru Hayakawa, et al. "Immunohistochemical study of metastatic brain tumors with astroprotein (GFAP), a glia-specific protein." Journal of Neurosurgery 62, no. 3 (1985): 414–18. http://dx.doi.org/10.3171/jns.1985.62.3.0414.

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✓ Tissues from 12 metastatic tumors of the brain were studied immunohistochemically with an antiserum to a glia-specific protein, astroprotein (glial fibrillary acidic protein, GFAP). Emphasis was laid on demonstrating the tissue architecture of metastatic lesions incorporating brain-derived components (astrocytes and glial fibers). Of 12 samples, 11 manifested a number of irregular indentations at the tumor surface. These indentations, which contained astrocytic elements, extended into the tumor tissue in a tapering fashion. In seven cases, the deeper stromal portions of the tumor also contai

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Schugar, Rebecca C., Steven M. Chirieleison, Kristin E. Wescoe, et al. "High Harvest Yield, High Expansion, and Phenotype Stability of CD146 Mesenchymal Stromal Cells from Whole Primitive Human Umbilical Cord Tissue." Journal of Biomedicine and Biotechnology 2009 (2009): 1–11. http://dx.doi.org/10.1155/2009/789526.

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Human umbilical cord blood is an excellent primitive source of noncontroversial stem cells for treatment of hematologic disorders; meanwhile, new stem cell candidates in the umbilical cord (UC) tissue could provide therapeutic cells for nonhematologic disorders. We show novel in situ characterization to identify and localize a panel of some markers expressed by mesenchymal stromal cells (MSCs; CD44, CD105, CD73, CD90) and CD146 in the UC. We describe enzymatic isolation and purification methods of different UC cell populations that do not require manual separation of the vessels and stroma of

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Bambuliak, A. V., N. B. Kuzniak, R. R. Dmitrenko, S. V. Tkachik, and V. A. Honcharenko. "Microscopic Investigation of Compatibility of Samples Containing Multipotent Mesenchimal Stromal Cells of Additive Tissue in Experimental Conditions." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 6 (2020): 59–65. http://dx.doi.org/10.26693/jmbs05.06.059.

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The purpose of the study was to investigate the biocompatibility of samples containing multipotent mesenchymal stromal cells of adipose tissue to replace bone defects. Material and methods. The study was conducted at Bukovina State Medical University, Chernivtsi, Ukraine. Adipose tissue samples were obtained from the neck of 60 experimental animals (white Wistar rats). We selected 4 samples for the toxicological experiment, which allowed to establish the direct influence of factors in the contact of implantation material at the cellular level. Sample № 1 - Multipotent mesenchymal stromal cells

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Copcu, H. Eray. "Indication-based protocols with different solutions for mechanical stromal-cell transfer." Scars, Burns & Healing 8 (January 2022): 205951312110478. http://dx.doi.org/10.1177/20595131211047830.

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Background Regenerative medicine is the fastest developing branch of plastic surgery in recent times. Adipose tissue is one of the largest and most important sources in the body for stromal cells. Although mechanical isolation methods are both very popular and have many advantages, they still have no accepted protocols. Objective We developed new protocols called indication-based protocols (IPs) for standardization and new techniques called mechanical stromal-cell transfer (MEST) by using ultra-sharp blades and dilution of adipose tissue with different solutions (saline, Ringer and 5% Dextrose

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Miller, James L., Alexandra Reddy, Rebecca M. Harman, and Gerlinde R. Van de Walle. "A xenotransplantation mouse model to study physiology of the mammary gland from large mammals." PLOS ONE 19, no. 2 (2024): e0298390. http://dx.doi.org/10.1371/journal.pone.0298390.

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Although highly conserved in structure and function, many (patho)physiological processes of the mammary gland vary drastically between mammals, with mechanisms regulating these differences not well understood. Large mammals display variable lactation strategies and mammary cancer incidence, however, research into these variations is often limited to in vitro analysis due to logistical limitations. Validating a model with functional mammary xenografts from cryopreserved tissue fragments would allow for in vivo comparative analysis of mammary glands from large and/or rare mammals and would impro

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Syed-Picard, Fatima N., Yiqin Du, Andrew J. Hertsenberg, et al. "Scaffold-free tissue engineering of functional corneal stromal tissue." Journal of Tissue Engineering and Regenerative Medicine 12, no. 1 (2017): 59–69. http://dx.doi.org/10.1002/term.2363.

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