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1

Shah, Yatin. "Strophanthin – ein besonderes Herzglykosid." Zeitschrift für Komplementärmedizin 3, no. 02 (2011): 48–51. http://dx.doi.org/10.1055/s-0030-1270928.

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2

Schmidramsi, H., B. Ostermayr, and J. v. Arnim. "Proving of g-strophanthin." British Homoeopathic journal 82, no. 4 (1993): 269. http://dx.doi.org/10.1016/s0007-0785(05)80679-9.

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3

Tsyvunin, V. V., S. Yu Shtrygol, D. V. Shtrygol, and D. P. Kavraiskyi. "Anticonvulsive potential of cardiac glycosides under conditions of pentilentetrazole-induced seizures in mice: comparative study." Acta Medica Leopoliensia 27, no. 1-2 (2021): 63–69. http://dx.doi.org/10.25040/aml2021.01-02.063.

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Aim. The research provides a comparative analysis of the possible anticonvulsant action of different cardiac glycosides, namely: digoxin, lanatoside C, strophanthin G and corglycone. In addition, it detrmines the leading medication among the abovementioned ones by dose-dependence of its anticonvulsant action. Material and Methods. The research was performed on 66 random-bred albino male mice. The anticonvulsant effect of cardiac glycosides was studied in a baseline model of pentylenetetrazole-induced seizures. The first series of experiment evaluated the effect of cardiac glycosides on the cou
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4

Vilensky, L. "Strofantin and novazurol for heart disease." Kazan medical journal 20, no. 9 (2021): 990–91. http://dx.doi.org/10.17816/kazmj77072.

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Weiss (Deut, med Woch., 1924 No. 33) reports on his observations on the treatment of severe cardiac patients with strophanthin and novosurol. In chronic heart diseases in a state of sharp decompensation, sometimes digitalis has no effect, especially when the body, due to the prolonged use of small doses of digitalis, has become accustomed to this remedy.
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5

McKenzie, A. G. "The rise and fall of strophanthin." International Congress Series 1242 (December 2002): 95–100. http://dx.doi.org/10.1016/s0531-5131(02)00729-x.

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6

Dadashyan, A. M. "Experience in the use of convallotoxin in circulatory failure." Kazan medical journal 43, no. 5 (2021): 52–53. http://dx.doi.org/10.17816/kazmj87787.

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In the domestic literature, there are very few works on the action of convallotoxin, but they testify to the great effectiveness of the drug in patients with cardiovascular insufficiency. KA Khasanov believes that the therapeutic effect of konvallotoxin is not inferior to strophanthin, has a pronounced vascular and sedentary effect. LI Zhukovsky and BM Klebanov, noting the positive effect of konvallotoxin, pay attention to its side effects (the occurrence of pain and a feeling of compression in the heart, palpitations, shortness of breath, headaches, etc.).
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7

Frost, Jørgen, and Erik Warburg. "Clinical experiences concerning the effect of strophanthin." Acta Medica Scandinavica 130, S206 (2009): 132–44. http://dx.doi.org/10.1111/j.0954-6820.1948.tb12030.x.

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8

Ionova, E. O., I. A. Miroshkina, A. V. Sorokina, and S. A. Kryzhanovskii. "Comparative evaluation of echocardiographic and morphometric characteristics of the rat heart left ventricle." Pharmacokinetics and Pharmacodynamics, no. 1 (May 10, 2023): 41–44. http://dx.doi.org/10.37489/2587-7836-2023-1-41-44.

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Purpose of the study. Comparative evaluation of echocardiographic and morphometric dimensions of the rat heart left ventricle. Materials and methods. The study included 10 outbred male rats weighing 160–180 g. The size of the heart left ventricle was assessed using echocardiography and morphometry. The measurements were carried out according to standard protocols. To perform morphometric measurements, hearts were stopped in systole with a lethal dose (1.0 mg/kg) of 0.025 % strophanthin K solution, and in diastole, by immersing the hearts in a chilled physiological solution (calcium-free medium
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9

Grosa, Giorgio, Gianna Allegrone, and Erika Del Grosso. "LC–ESI-MS/MS characterization of strophanthin-K." Journal of Pharmaceutical and Biomedical Analysis 38, no. 1 (2005): 79–86. http://dx.doi.org/10.1016/j.jpba.2004.12.008.

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10

Mosyagin, Vladimir. "THE INFLUENCE OF ELECTROLYTES OF THE IONS AND THE INHIBITOR ON THE ACTIVITY OF TOTAL ATPASE OF ERYTHROCYTES OF BROILER CHICKENS." Research Results in Pharmacology 2, no. (2) (2016): 113–18. https://doi.org/10.18413/2313-8971-2016-2-2-113-118.

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The total ATPase activity of erythrocytes of broiler chickens depends on the concentration of ions Na+ and K+. The ATPase activity at 76.5% due to magnesium ions, 96.5% of the sodium ions and 47.6% of potassium ions. Maximum ATPase activity was observed in incubation medium containing ions: Na+ 120 mmol/ml, K+ 20 mmol/ml; Mg2+ - 3.0 mmol/ml and was of 9,240,23 nmol •mg protein-1•min-1. The ATPase activity has no effect of the specific inhibitor – strophanthin-K in the concentration range of 0-100 mg•l-1 in the medium containing ions Na+ and K+, and in an environment without them.
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11

Olesin, A. I., I. V. Konstantinova, N. N. Tyuteleva, and V. S. Ivanov. "Clinical and prognostic significance of left ventricular dysfunction predictors in patients with ventricular ectopy and without structural heart disease." Fundamental and Clinical Medicine 8, no. 3 (2023): 53–67. http://dx.doi.org/10.23946/2500-0764-2023-8-3-53-67.

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Aim. To determine the predictors of left ventricular dysfunction in patients with ventricular ectopic beats without structural heart disease.Material and Methods. We modeled ventricular ectopy in rats through early afterdepolarization (aconitine-induced arrhythmia) and delayed afterdepolarization (adrenaline arrhythmia). In addition, we modeled ventricular ectopy in rabbits and cats by delayed afterdepolarization (barium chloride-induced and strophanthin arrhythmias, respectively) and also modeled ventricular ectopy in dogs by re-entry hydrogen peroxide-induced arrhythmia. In addition to conve
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12

Arnim, H. Schmidramsl; B. Ostermayr; J. v. "g-Strophanthin - Ergebnisse von 2 Arzneimittelprüfungen mit der 4. Dezimalpotenz." Allgemeine Homöopathische Zeitung 238, no. 03 (2007): 106–9. http://dx.doi.org/10.1055/s-2006-936451.

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13

Chekman, I. S., N. A. Gorchakova, V. V. Bratus', and I. S. Mudraya. "Combined inotropic effect of strophanthin and calcium on heart muscle." Bulletin of Experimental Biology and Medicine 99, no. 3 (1985): 317–20. http://dx.doi.org/10.1007/bf00799077.

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14

Galenko-Yaroshevskii, P. A., S. M. Lemkina, and Ya V. Kostin. "Drug correction of impaired strophanthin tolerance during simulated cardiac decompensation." Bulletin of Experimental Biology and Medicine 117, no. 5 (1994): 483–86. http://dx.doi.org/10.1007/bf02444295.

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15

Bogus, Saida K., Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Galina V. Sukoyan, and Valery G. Abushkevich. "2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1 H-indole hydrochloride (SS-68): Antiarrhythmic and cardioprotective activity and its molecular mechanisms of action (Part I)." Research Results in Pharmacology 4, no. 1 (2018): 130–55. http://dx.doi.org/10.3897/rrpharmacology.4.28592.

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Introduction. The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound 2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1H-indole hydrochloride (SS-68) belongs to, are a promising chemical group in terms of their cardio-pharmacological activity. Materials and methods. To study the anti-arrhythmic activity of SS-68 compound, the following models were used: 1) Models of cardiogenic arrhythmia: aconitine-inducedic, calcium chloride-induced, barium chloride-
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16

Bogus, Saida K., Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Galina V. Sukoyan, and Valery G. Abushkevich. "2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1 H-indole hydrochloride (SS-68): Antiarrhythmic and cardioprotective activity and its molecular mechanisms of action (Part I)." Research Results in Pharmacology 4, no. (2) (2018): 133–50. https://doi.org/10.3897/rrpharmacology.4.28592.

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Introduction. The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound 2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1H-indole hydrochloride (SS-68) belongs to, are a promising chemical group in terms of their cardio-pharmacological activity. Materials and methods. To study the anti-arrhythmic activity of SS-68 compound, the following models were used: 1) Models of cardiogenic arrhythmia: aconitine-inducedic, calcium chloride-induced, barium chloride-
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17

Tawfik, Hoda, Alanna A. L. Fox, and Kurt Greeff. "Comparative studies of some semisynthetic K-strophanthins with natural cardiac glycosides." Biochemical Pharmacology 34, no. 14 (1985): 2541–47. http://dx.doi.org/10.1016/0006-2952(85)90540-4.

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18

Karsanov, N. V., G. V. Sukoyan, D. R. Tatulashvili, V. N. Karsanov та L. D. Mamulashvili. "Difference between mechanisms of action ofβ-acetyldigoxin, strophanthin K, and ouabain". Bulletin of Experimental Biology and Medicine 113, № 2 (1992): 186–89. http://dx.doi.org/10.1007/bf00791495.

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19

Krupin, Theodore, Lisa F. Rosenberg, Arnold L. Sandridge, Charles J. Bock, Adrienne Berman, and Jon M. Ruderman. "Effects of Topical K-Strophanthin on Aqueous Humor and Corneal Dynamics." Journal of Glaucoma 4, no. 5 (1995): 327???333. http://dx.doi.org/10.1097/00061198-199510000-00006.

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20

Olesin, Alexander I., Irina V. Konstantinova, Natalia N. Tyuteleva, Julia S. Zueva, Vladimir S. Ivanov, and Anastasia V. Koziy. "POLYMORPHIC VENTRICULAR EXTRASYSTOLIA IN PATIENTS WITHOUT STRUCTURAL CHANGES IN THE HEART: CLINICAL AND PROGNOSTIC SIGNIFICANCE AND ASSESSMENT OF THE EFFECTIVENESS OF THE THERAPY (CLINICAL AND EXPERIMENTAL STUDY)." Complex Issues of Cardiovascular Diseases 14, no. 1 (2025): 180–90. https://doi.org/10.17802/2306-1278-2025-14-1-180-190.

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HighlightsIn patients without structural changes in the heart, predictors of arrhythmogenic cardiomyopathy were recorded significantly more often when polymorphic left ventricular extrasystole was detected.When predominantly polymorphic right ventricular extrasystoles were detected in patients without structural changes in the heart, the pathology of the cardiovascular system was not recorded, but with polymorphic left ventricular extrasystole, the development of pathology of the cardiovascular system, such as various clinical forms of coronary heart disease, hypertension, and mitral valve pro
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21

ZENG, YONG-CHUN, ZHENG-JUN JIN, and PEI-KUN GU. "Retinal Toxicity in Albino Rabbits Induced by Intravitreal Injection of Strophanthin-K." Journal of Ocular Pharmacology and Therapeutics 6, no. 1 (1990): 51–60. http://dx.doi.org/10.1089/jop.1990.6.51.

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22

Sobieva, Z. I., M. N. Karpova, and E. G. Kryzhanovskaya. "Effect of lithium compounds on cardiac arrhythmias induced by strophanthin in conscious rats." Bulletin of Experimental Biology and Medicine 99, no. 4 (1985): 410–13. http://dx.doi.org/10.1007/bf00842725.

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23

Kudryavtseva, N. P., V. I. Kachurets, and S. X. Nasibullina. "The use of strophanthin in the complex treatment of cardiovascular disorders in toxic diphtheria." Kazan medical journal 43, no. 3 (2021): 42–43. http://dx.doi.org/10.17816/kazmj83692.

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24

ÖSTLING, GUSTAF. "The Significance of the Speed of Injection for the Therapeutic Effect of K-Strophanthin." Acta Medica Scandinavica 129, no. 1 (2009): 77–80. http://dx.doi.org/10.1111/j.0954-6820.1947.tb09286.x.

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25

Guang-tian, Yang, and S. Daum. "Wirkung von Strophanthin, Digoxin und Isoproterenol auf die Herzkontraktilität während Hypoxie und hyperkapnischer Azidose." Journal of Tongji Medical University 6, no. 4 (1986): 199–205. http://dx.doi.org/10.1007/bf02909745.

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26

Sergeev, P. V., P. A. Galenko-Yaroshevskii, S. M. Lemkina, and Ya V. Kostin. "Comparative evaluation of pharmacological effects of combined application of strophanthin with some antiadrenergic agents." Bulletin of Experimental Biology and Medicine 119, no. 5 (1995): 484–87. http://dx.doi.org/10.1007/bf02543436.

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27

Pogorelova, V. N., A. I. Panait, and A. G. Pogorelov. "Nonspecific effect of Na+/K+-ATPase inhibition with strophanthin or under hypothermia in rat heart." Biophysics 59, no. 5 (2014): 768–71. http://dx.doi.org/10.1134/s0006350914050212.

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28

Rajabzoda, M. M. "Consequences of road transportation accidents, their standard growth, modern management and tactics of treatment of victims." Health care of Tajikistan, no. 2 (July 21, 2022): 82–87. http://dx.doi.org/10.52888/0514-2515-2022-353-2-83-88.

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Aim. Improvement of the results of diagnostics and provision of pre- and hospital medical care to victims with concomitant and multiple trauma in road accidents. Material and research methods. Based on the analysis of the results of diagnosis and treatment, it was found that the Department of Traumatology and Orthopedics of the Regional Clinical Hospital named after B. Vohidov of the city of Bokhtar (former Kurgan-Tyube) for the period 2012 - 2020. there were 2120 patients with injuries. 1234 (58.2 %) victims were injured as a result of road accidents. Research results and their discussion. Pr
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29

Bauer, N., G. Scheiner-Bobis, and W. Schoner. "„Endogenes Digitalis” – der lange Weg vom herzwirksamen pflanzlichen Toxin zum Hormon der Säuger." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 34, no. 06 (2006): 389–97. http://dx.doi.org/10.1055/s-0037-1622553.

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ZusammenfassungEndogene Herzglykoside wurden kürzlich aus Blut, Urin, Nebennieren und Hypothalamus von Säugetieren isoliert und in ihrer Struktur aufgeklärt. Zu den endogenen Herzglykosiden zählen so gut bekannte Hemmstoffe der Natriumpumpe wie Ouabain (g-Strophanthin), Digoxin und Marinobufagenin. Endogenes Ouabain und Digoxin werden in der Nebennierenrinde der Säuger aus Progesteron und Pregnenolon synthetisiert. Ouabain wird bei Kreislaufbelastung rasch freigesetzt, seine Konzentration fällt bei Ruhe innerhalb weniger Minuten wieder ab. ACEInhibitoren und β-Blocker verhindern bei Hunden die
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30

Sørensen, Else Vigholt, and Folmer Nielsen-Kudsk. "Single and combined myocardial pharmacodynamics of xamoterol, isoprenaline and g-strophanthin in the isolated rabbit heart." European Journal of Pharmacology 125, no. 3 (1986): 363–71. http://dx.doi.org/10.1016/0014-2999(86)90792-2.

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31

Mikhailov, I. B. "Effect of strophanthin and digoxin on activity of an experimental epileptogenic focus in the frog hippocampus." Bulletin of Experimental Biology and Medicine 104, no. 5 (1987): 1572–74. http://dx.doi.org/10.1007/bf00845084.

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32

Roshni, SS, Sneha Geevarghese, S. Sujith, Preethy John, R. Uma, and AR Nisha. "Evaluation of cytotoxic potential of leaves of Cyclea peltata in MCF-7 cell lines." Journal of Phytopharmacology 14, no. 2 (2025): 78–86. https://doi.org/10.31254/phyto.2025.14202.

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It is a well-established fact that breast cancer causes severe mortality among women globally. The invention of a vast number of medications currently used in the treatment of cancer was made possible from studies on natural products. Cyclea peltata is a locally available medicinal plant which has been used for the treatment of various diseases including diabetes. The present study reports the antiproliferative and cytotoxic action of alcoholic extract and its fractions of the leaves of C. peltata in MCF-7 cell lines. The extract of C. peltata and its fractions were subjected to qualitative ph
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33

Fazulzyanov, A. A., V. M. Andreev, and G. N. Fazulzyanova. "Respiratory mechanics, alveolar ventilation, ventilation-perfusion relations in the correction of heart failure with strophanthin and kapoten." Kazan medical journal 76, no. 6 (1995): 417–19. http://dx.doi.org/10.17816/kazmj90429.

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In patients with chronic heart failure due to chronic heart disease (rheumatic heart disease, hypertension, coronary artery disease with postinfarction and atherosclerotic cardiosclerosis), changes in pulmonary hemodynamics contribute to the development of respiratory failure.
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34

Bonah, Christian. "‘The Strophanthin question’: early scientific marketing of cardiac drugs in two national markets (France and Germany, 1900–1930)." History and Technology 29, no. 2 (2013): 135–52. http://dx.doi.org/10.1080/07341512.2013.833039.

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35

Hassan, A. B., M. Atef, and I. M. Shihata. "Effect of Digoxin and Strophanthin on Renal Blood Flow and Systemic Blood Pressure in Normal and Bled Dogs." Zentralblatt für Veterinärmedizin Reihe A 26, no. 2 (2010): 152–58. http://dx.doi.org/10.1111/j.1439-0442.1979.tb00660.x.

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36

Galenko-Yaroshevskii, P. A., S. M. Lemkina, and Ya V. Kostin. "Effects of the membrane stabilizer ajmaline and the local anesthetic trimecaine on the pharmacological effects of strophanthinin vivo andin vitro." Bulletin of Experimental Biology and Medicine 117, no. 1 (1994): 61–64. http://dx.doi.org/10.1007/bf02444082.

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37

Karsanov, N. V., T. N. Macharashvili, and V. A. Magaldadze. "Action of strophanthin K and ?-acetyldigoxin in vitro on energy transformation by the contractile protein system of normal cardiomyocytes." Bulletin of Experimental Biology and Medicine 108, no. 6 (1989): 1735–38. http://dx.doi.org/10.1007/bf00841047.

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38

Galenko-Yaroshevskii, P. A., S. M. Lernkina, and Ya V. Kostin. "Correction with cordarone of changes in cathepsin D activity induced by modeled circulation insufficiency and toxic action of strophanthin K." Bulletin of Experimental Biology and Medicine 122, no. 4 (1996): 1005–7. http://dx.doi.org/10.1007/bf02447021.

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39

Galenko-Yaroshevskii, P. A., S. M. Lemkina та Ya V. Kostin. "Correction of altered β-glucosidase activity induced by the toxic effect of strophanthin K and modeled cardiac decompensation with cordaron". Bulletin of Experimental Biology and Medicine 121, № 6 (1996): 581–83. http://dx.doi.org/10.1007/bf02447123.

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40

Karsanov, N. V., V. A. Magaldadze, and T. N. Macharashvili. "Action of strophanthin K and ?-acetyldigoxin in vitro on energy transformation by the myocardial contractile protein system in toxico-allergic cardiomyopathy." Bulletin of Experimental Biology and Medicine 111, no. 5 (1991): 698–700. http://dx.doi.org/10.1007/bf00841022.

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41

Agostoni, Pier Giuseppe, Elisabetta Doria, Marco Berti, and Maurizio D. Guazzi. "Long-term use of K-strophanthin in advanced congestive heart failure due to dilated cardiomyopathy: A double-blind crossover evaluation versus digoxin." Clinical Cardiology 17, no. 10 (1994): 536–41. http://dx.doi.org/10.1002/clc.4960171005.

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42

Krvavych, Anna, and Roksolana Konechna. "Optimization of parameters of the extraction process of biologically active substances of grass Adonis vernalis." Technology audit and production reserves 3, no. 3(59) (2021): 14–18. http://dx.doi.org/10.15587/2706-5448.2021.235471.

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The object of this research is the herb Adonis vernalis and hydroalcoholic extracts obtained on its basis. By the nature of the action, the drugs Adonis vernalis belong to the group of cardiac glycosides and occupy an intermediate place between strophanthin and digitalis. In official medicine, biologically active compounds of Adonis vernalis are included in drugs such as Cardiovalen, Adonis-bromine, Caridiolin and Cardiophyte. In the extemporal formulation, the extract is part of the Bechterew’s medicine. Until recently, scientists have made significant progress in studying the phytochemical a
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43

Anna, Krvavych, and Konechna Roksolana. "Optimization of parameters of the extraction process of biologically active substances of grass Adonis vernalis." Technology audit and production reserves 3, no. 3(59) (2021): 14–18. https://doi.org/10.15587/2706-5448.2021.235471.

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<em>The object of this research is the herb Adonis vernalis and hydroalcoholic extracts obtained on its basis. By the nature of the action, the drugs Adonis vernalis belong to the group of cardiac glycosides and occupy an intermediate place between strophanthin and digitalis. In official medicine, biologically active compounds of Adonis vernalis are included in drugs such as Cardiovalen, Adonis-bromine, Caridiolin and Cardiophyte. In the extemporal formulation, the extract is part of the Bechterew&rsquo;s medicine. Until recently, scientists have made significant progress in studying the phyto
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44

Galust'yan, G. �., and I. B. Mikhailov. "Effect of strophanthin and digoxin on succinate and lactate dehydrogenase and membrane Na+, K+-ATPase activity in the heart of rats with experimental myocarditis." Bulletin of Experimental Biology and Medicine 107, no. 4 (1989): 498–500. http://dx.doi.org/10.1007/bf00842388.

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45

Danielopolu, D., Marin Popescu, and Gr Gr Popa. "Action of Drugs on Cholinesterase and on the Adrenolytic Factors. Inactivating Action of Eserine, Strophanthin and Ascorbic Acid on Cholinesterase and on the Adrenolytic Factors." Acta Pharmacologica et Toxicologica 4, no. 3-4 (2009): 339–50. http://dx.doi.org/10.1111/j.1600-0773.1948.tb03356.x.

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46

Datté, J. Y., and A. Ziegler. "Pharmacological investigation on nigrescigenin-a cardenolide fromParquetina nigrescens(Afzel.) Bullock: comparative studies on cardiotonic effects ofParquetina nigrescens, g-strophanthin and noradrenaline in guinea-pig isolated atria." Journal of Pharmacy and Pharmacology 53, no. 6 (2001): 859–66. http://dx.doi.org/10.1211/0022357011776018.

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47

Sugimoto, Jiro, Seiichi Yuasa, and Masayasu Suzuki. "Comparison of Effects of Alprenolol, Carteolol, Indenolol, Pindolol, Practolol, and Propranolol in Relation to their Beta-Blocking, Local Anaesthetic, Membrane Stabilizing, and Strophanthin-G Cardiotoxicity Antagonizing Actions in Guinea-Pig." Journal of Kansai Medical University 39, no. 4 (1987): 418–29. http://dx.doi.org/10.5361/jkmu1956.39.4_418.

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48

Doepp, Manfred. "May Strophanthin be a valuable cardiac drug ?" American Journal of Medical and Clinical Research & Reviews 02, no. 09 (2023). http://dx.doi.org/10.58372/2835-6276.1069.

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49

"Die Lösung des Herzinfarkt-Problems durch g-Strophanthin." Erfahrungsheilkunde 53, no. 02 (2004): 65–73. http://dx.doi.org/10.1055/s-2004-819994.

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Sharma, Ashish Kumar, Shivam Singh, Mehvish Bhat, et al. "New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-41942-4.

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Abstract:
AbstractCardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial infarction. Both traditional and genetic animal models are: In-vitro: Isolated ventricular Myocytes, Guinea pig papillary muscles, Patch-Clamp Experiments, Porcine Atrial Myocytes, Guinea pig ventricular myocytes, Guinea pig papillary muscle: action potential and refractory period, Langendor
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