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Dissertations / Theses on the topic 'Structural complex'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

Kelley, Kotaro. "Structural and biochemical characterization of nuclear pore complex structural scaffold sub-complexes." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/113466.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2017<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The nuclear pore complex (NPC) is a large, modular protein assembly that regulates nucleocytoplasmic transport in all eukaryotes. The ~60-120 MDa NPC is a modular assembly of multiple copies of ~30 distinct proteins that are arranged into biochemically distinct sub-complexes. We believe that the structural characterization of the NPC is essential for understanding its transport mechanisms and various pathologies and human disease

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2

Carroni, Marta. "Structural arrangement of the GINS complex." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521129.

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3

Bailey, Matthew James. "Structural Studies of the GTNS Complex." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522872.

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4

Murthy, Andal Srinivasa. "Structural studies of the NuRD complex." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648352.

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5

Rodríguez-Dávila, Héctor M. "Optimum design for feedforward structural-acoustic control of complex structural systems." Diss., Virginia Tech, 1996. http://hdl.handle.net/10919/40254.

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6

McGregor, Natalie. "Structural Investigation of RecU-Holliday Junction Complex." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485112.

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RecD is the general Holliday junction resolvase in Gram-positive bacteria and is 2 required for efficient homologous DNA recombination and repair. X-ray crystallographic techniques and biochemical experiments have been employed to give insight into RecD-Holliday junction binding and its interaction with other known proteins in this DNA repair pathway. The 2.2 A crystal structure of Bacillus subtilis RecU was determined using multiple isomorphous replacement. In addition, structures containing divalent cation and the D88A variant were also determined. The enzyme fold reveals a striking similari

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7

Bachmann, Guorun. "Structural studies of the separase-securin complex." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542791.

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8

Dean, Nicky. "Electronic and structural dynamics of complex materials." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543469.

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9

Yao, Jing Wen. "Systematic structural studies in metal complex chemistry." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/5055/.

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A procedure is presented for detecting geometrical preferences, deformations and interconversion pathways between different geometries for the transition metal coordination sphere ML(_n). A discrepancy index [R(_ang)(x)] was proposed initially to address the problems of dimensionality and permutation complexity in the systematic analysis of coordination sphere geometry with higher coordination numbers (n > 7). But it can also be used generally for the lower coordination numbers. A set of standard geometries for coordination numbers 2-9 are presented and the angles between the center point and

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10

Dana, Christopher David. "Structural Characterization of the Flavonoid Enzyme Complex." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/28356.

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Flavonoid biosynthesis is an important secondary metabolic pathway in higher plants with a range of vital functions in plants and animals. This pathway has been developed as a model system for the study of multi-enzyme complexes. The goal of the work presented here was to structurally characterize a series of loss-of-function chalcone synthase (CHS) alleles and to define the molecular basis of the interaction between CHS and the second enzyme of flavonoid biosynthesis, chalcone isomerase (CHI). CHS proteins encoded by five previously characterized alleles were characterized by homology mode

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11

Marciano, Gabriele. "Structural characterization of FACT histone chaperone complex." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6759/.

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Due to the huge amount of DNA and the small space in which this is stored, cells package DNA into condensed chromatin. During DNA replication, repair or transcription, cells need to reorganize chromatin structure in order to gain access to the DNA. To do so they use a wide range of enzyme that can modify chromatin structure such as acetyltransferases, methyltransferases and others. Chromatin remodelling is also accomplished by ATP dependent and independent histone chaperones. One of the ATP independent histone chaperones is FACT (facilitate chromatin transcription), which is a heterocomplex of

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12

Coccon, Marco. "Structural Reliability Analysis of Complex Systems: Applications to Offshore and Composite Structures." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424201.

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This thesis aims at developing new methodologies for the reliability analysis of structural systems with applications to offshore and aeronautical fields. In general, sructures of practical interest are complex redundant systems, in which more than one element is required to fail in order to have catastrophic failure. Moreover, ramdomness inherently exists in both material properties and external loads. As a result, complex structural systems are typically characterised by a huge number of possible failure sequences, of which only some are most likely to occour. Therefore, for an efficient ris

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13

Ramakrishnan, Venkatesh. "Structural analysis of a transactivation domain cofactor complex." Doctoral thesis, [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976325381.

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14

Bose, Daniel. "Structural studies of an intermediate transcription initiation complex." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501545.

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15

Liu, Jing-Xia. "Human muscle spindles : complex morphology and structural organisation." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-356.

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16

Schreiber, Anne. "Structural studies of the anaphase promotinq complex/cyclosome." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539894.

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17

Farshchian, Mona. "Structural elucidation of mRNA(Sirt1)-microRNA 34a complex." Thesis, KTH, Skolan för teknikvetenskaplig kommunikation och lärande (ECE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168623.

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The aim of this thesis is to understand RNA-RNA interactions steering cellular functions, as in the case of this thesis the structure of mRNA(Sirt1) in complex with microRNA-34a (miR-34a). MiR-34a regulates the cancer protein p53 via Sirt1 modulation. This work will be the basis for future drug design and the understanding of misguided regulation in cancer. The miR-34a binds to the mRNA(Sirt1) 3’ untranslated region (3’-UTR) and will either inhibit the translation of the protein Sirtuin 1 by capturing its mRNA or by degrading it. p53, a key activator of miR-34a, prevents cancer development by

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18

Mitchell, S. H. "Structural studies on some complex compounds containing imines." Thesis, Cardiff University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332450.

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19

Srivastava, Sweta. "Structural and functional characterisation of the exocyst complex." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275775.

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20

Esmaielbeiki, Reyhaneh. "Structural complex prediction based on protein interface recognition." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/28209/.

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This dissertation contributes to the state of the art in protein interface prediction and detection of native-like docked poses by re-ranking them using protein interface knowledge. We started by investigating binding site patterns among homologues of a target protein in order to create a 3D motif. This structural binding site descriptor enables the re-ranking of docked complexes of the target protein. Although 3D motifs provide biological insight of protein interactions and have usage in real applications, they are not suitable for high through-put analysis. Therefore, we introduced a novel p

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21

King, Graham Missell. "Structural, Magnetic, and Electronic Studies of Complex Perovskites." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1262114272.

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22

Ko, Hyunjin. "Structural and electronic investigations of complex intermetallic compounds." [Ames, Iowa : Iowa State University], 2008.

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23

Yang, Wei. "Studies on the structural organization of Golgi complex." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-02132009-172025/.

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24

Jaokar, T. "Structural studies of selected mitochondrial complex-I subunits." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2014. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2218.

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25

Pascual, Blanca. "Uncertainty quantification for complex structures : statics and dynamics." Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa42987.

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26

Durand, Alexandre. "Structural study of the transcriptional co-activator SAGA." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ051/document.

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Le complexe SAGA (Spt-Ada-Gcn5 acetyl transferase) est un co-activateur transcriptionel, conservé chez les eucaryotes, qui participent à la transcription d’environ 10% des gènes chez la levure, où il fait le lien entre les composants du complexe de pré-initiation, tel que la TATA-box Binding Protein (TBP) et des activateurs, et modifie les histones dans le contexte de la chromatine (acétylation et déubiquitination). Ces travaux de thèse ont permis de décrire l’architecture moléculaire du complexe observée par microscopie électronique. Nous avons pu (i) localiser le module de déubiquitination a

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27

Murachelli, Andrea Giovanni. "Structural studies on ASAP, a conserved, EJC-associated complex." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138594.

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28

Leonova, Ekaterina. "Structural Investigations of Complex Glasses by Solid-state NMR." Doctoral thesis, Stockholms universitet, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8565.

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This PhD thesis presents structural investigations of amorphous inorganic materials: oxide and oxynitride glasses and mesoporous bioactive glasses (MBGs), by solid-state Nuclear Magnetic Resonance (NMR). Lanthanum oxide and oxynitride [La-Si-(Al)-O-(N)] glasses have a large number of potential applications due to their physical properties. In our work we have studied, compared to previous investigations, significantly expanded ranges of glass compositions (for oxynitride glasses, including samples of very high nitrogen content, up to 53 % out of the anions). We have estimated local environment

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29

Zhang, Pamela Peng. "Structural and Biochemical Dissection of the KMT2 Core Complex." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32479.

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Histone H3 lysine 4 (H3K4) methylation is an evolutionarily conserved mark commonly associated with transcription activation in eukaryotes. In mammals, this post-translational modification is deposited by the KMT2 family of H3K4 methyltransferases. Biochemical studies have shown that the enzymatic activity of the KMT2 enzymes is regulated by a core complex of four evolutionarily conserved proteins: WDR5, RbBP5, ASH2L and DPY30, collectively known as WRAD, which are all important for global H3K4 methylation. However, how these proteins interact and regulate the activity of the KMT2 enzymes is n

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30

Lyytik�inen, Katja Johanna. "Control of complex structural geometry in optical fibre drawing." University of Sydney. School of Physics and the Optical Fibre Technology Centre, 2004. http://hdl.handle.net/2123/597.

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Drawing of standard telecommunication-type optical fibres has been optimised in terms of optical and physical properties. Specialty fibres, however, typically have more complex dopant profiles. Designs with high dopant concentrations and multidoping are common, making control of the fabrication process particularly important. In photonic crystal fibres (PCF) the inclusion of air-structures imposes a new challenge for the drawing process. The aim of this study is to gain profound insight into the behaviour of complex optical fibre structures during the final fabrication step, fibre drawing.

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31

Lyyttkäinen, Katja Johanna. "Control of complex structural geometry in optical fibre drawing /." Connect to full text, 2004. http://setis.library.usyd.edu.au/adt/public_html/adt-NU/public/adt-NU20041011.120247.

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32

Wheeler, Susan F. "Structural determination of complex anionic oligosaccharides by mass spectrometry." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365367.

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33

Chang, J. F. "Structural and functional studies of a transcription regulatory complex." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597458.

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The expression of immunoglobulin genes is controlled in part by the broadly expressed DNA-binding protein Oct-1 and the B cell-specific transcription co-activator, Bob1 (also known as OCA-B or OBF-1) that, together, form a complex on the immunoglobulin gene promoter. Bob1 interacts with the DNA-binding domain (the POU domain) of Oct-1 to specifically recognise the octamer DNA sequence, ATGCAAAT found in he promoter region. This thesis describes biophysical studies of the assembly of this complex. First, the binding of Oct-1 POU to the octamer element has been characterised using isothermal tit

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34

McDermott, Gerry. "Structural studies on an integral membrane light-harvesting complex." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337507.

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35

Lamm, Gabor Mihaly. "Structural and functional analysis of the mammalian splicing complex." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384999.

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36

Courtier, Mark. "Guided wave structural health monitoring of complex aerospace components." Thesis, University of Bristol, 2018. http://hdl.handle.net/1983/0ca49244-00ce-47c2-94d2-547c3f58b951.

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The main focus in this work has been to improve the understanding of how the monitored structure affects the performance of guided wave acoustic emission systems. This was to address poor performance of an Airbus acoustic emission system when it was used to monitor a complex section of an aircraft wing during a fatigue test. To do this the whole acoustic emission system was modelled. The focus of the modelling effort was in two parts. The first was to define a suitable source for a fatigue crack in aluminium to use as an input to the model. This was found from the literature and compared with

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37

Guo, Xuanzong. "Structural studies on the LINC complex and Fic-1." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97349.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 37-38).<br>LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. In this project testes-specific human SUN proteins (SUN3, SPAG4, and SUNS) were compared to ubiquitously-expressed SUN2. Secondly, fission and budding yeast LINC complexes differ from human ones and w

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38

Maurer, Maik [Verfasser]. "Structural awareness in complex product design / Maik S. Maurer." München : Verl. Dr. Hut, 2007. http://d-nb.info/995117764/34.

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39

Ho, Kok Lian. "Structural studies of MeCP2 in complex with methylated DNA." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3801.

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DNA methylation is a common epigenetic mark that affects gene regulation, genomic stability and chromatin structure. In mammals, methylation is mainly found in the CpG dinucleotides. The CpG methylation signals can be recognised by the Methyl-CpG-Binding Protein (MBP) family which includes MeCP2, MBD1, MBD2, MBD3, MBD4 and Kiaso. MeCP2 and MBD1-4 (except mammalian MBD3) recognise methyl-CpG via their MBD domain whereas Kaiso interprets methylation through its Zn finger DNA binding domain. The TRD domains of MeCP2, MBD1 and MBD2 have been reported to recruit transcriptional co-repressors to the

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40

Požar, Martina. "On the nature of structural fluctuations in complex liquids." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS269.

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L'analyse de différents types de structuration, présents dans des liquides simples et complexes et leurs mélanges, a été réalisée en utilisant la méthode de la dynamique moléculaire. Les mélanges complexes ont au moins un composant associatif, tel que l'eau, les alcools (mono-ols et diols) et les amines. La structuration supra-moléculaire dans ces mélanges est détectée, décrite, quantifiée et liée aux interactions atome-atome entre les molécules. Ces systèmes ont des fluctuations aux comportements intéressants, comme le montrent les intégrales de Kirkwood-Buff. Leurs fonctions de corrélation s

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41

Lyytikäinen, Katja Johanna. "Control of complex structural geometry in optical fibre drawing." Connect to full text, 2004. http://hdl.handle.net/2123/597.

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Thesis (Ph. D.)--University of Sydney, 2004.<br>Title from title screen (viewed 14 May 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Physics, Faculty of Science. Includes bibliographical references. Also available in print form.

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42

Lyytikäinen, Katja Johanna. "Control of complex structural geometry in optical fibre drawing." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/597.

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Drawing of standard telecommunication-type optical fibres has been optimised in terms of optical and physical properties. Specialty fibres, however, typically have more complex dopant profiles. Designs with high dopant concentrations and multidoping are common, making control of the fabrication process particularly important. In photonic crystal fibres (PCF) the inclusion of air-structures imposes a new challenge for the drawing process. The aim of this study is to gain profound insight into the behaviour of complex optical fibre structures during the final fabrication step, fibre drawing.

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43

Lally, Ciara. "Structural and functional characterization of the arrestin-rhodopsin complex." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18570.

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Die Aufgabe des Proteins Arrestin ist die Beendigung der Signalweitergabe über den GPCR Signalweg. In Stäbchenzellen bindet Arrestin an Licht-aktiviertes phosphoriliertes Rhodopsin um die Signalweitergabe zu unterdrücken. Die Bindung von Arrestin an Rhodopsin erfolgt in zwei Schritten. Zunächst wechselwirkt Arrestin mit dem phosphorilierten C-Terminus von Rhodopsin und bildet einen prä-Komplex, dies induziert Konformationsänderungen im Arrestin wodurch die Bildung eines High-affinity Komplex unter Kopplung an den helikalen Kern des aktivierten Rezeptors erfolgen kann. Biochemische Untersuchung

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44

Semrau, Marta Stefania. "Structural characterization of PTG and PTG/PP1 protein complex." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/331852.

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PTG (protein targeting to glycogen) is a scaffolding protein that is involved in the activation of glycogen synthesis by bringing PP1 (type 1 protein phosphatase) to its substrates. It is proposed as a target for the treatment of Lafora disease (LD), a genetic disorder manifested by catastrophic teenage onset of progressive myoclonus epilepsy. In healthy neurons, PTG is downregulated by the laforin-malin complex resulting in very low glycogen production. Mutations in malin or laforin causes accumulation of PTG, which promotes glycogen synthesis by directing P

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45

Davis, Denny E. "Optimization of transducers for active structural acoustic control of complex structures using numerical techniques." Thesis, Virginia Tech, 1995. http://hdl.handle.net/10919/40657.

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46

Roudko, Vladimir. "Structural and functional characterisation of the CCR4- NOT deadenylation complex." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ101/document.

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La dégradation des ARN messagers (ARNm) est un processus universel extrêmement complexe. D’une manière semblable aux polymerases pour la transcription et ribosomes pour la traduction, les complexes de protéines effectuant la dégradation des ARNm sont précisément régulés. La dégradation des ARNm eucaryotes s’effectue selon un schéma conservé évolutivement qui est initié par la déadénylation résultant dans la formation de transcrits avec des queues polyA courtes. De tels intermédiaires sont alors dégradés par le clivage de leur coiffe suivi par une digestion exonucléolytique 5’-3’ effectuée par

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47

Strasser, Christoph Erik. "New ligands for gold : bonding mode and structural complex characterisation." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1466.

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Thesis (PhD (Chemistry and Polymer Science))--Stellenbosch University, 2008.<br>Novel gold(I) trithiophosphite complexes were synthesised by utilising the ligands P(SR)3 (R = Me, Ph) and 1,2-bis(1,3,2-dithiaphospholan-2-ylthio)ethane (2L). Reaction with (tht)AuCl or (tht)AuC6F5 readily yielded the corresponding complexes (RS)3PAuX and 2L(AuX)2 (X = Cl, C6F5) as well as {Au[P(SMe)3]2}CF3SO3. Structural characterisation by X-ray diffraction revealed linear complexes in part associating by Au…Au and/or Au…S contacts, two polymorphs of one compound associating by either Au…S interactions or p

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48

Pyrka, Gloria Jean. "Electrochemical and structural studies of one-dimensional copper charge transfer complexes." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184493.

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The electrochemistry of solid electrodes of charge transfer complexes of tetracyanoquinodimethane (TCNQ) and copper complexes with nitrogen containing chelates, such and dipyridylamine (dpaH), bipyridyl (bpy) and 1,10-dimethyl-2,9-phenanthroline (dmp), has been investigated with cyclic voltammetry. Pressed pellet electrodes of these complexes exhibit a broad electrochemically stable region. The oxidative and reductive breakdown reactions involve solid state reactions into the bulk electrode. These materials also act as electron mediators for glucose oxidation in glucose oxidase modified electr

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49

Walker, John Roman. "Structural studies of two macromolecular complexes, the synaptic complex of Cre recombinase and the decameric structure of rattlesnake venom lectin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ53805.pdf.

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50

King, Martin. "Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I)." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/228700.

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NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme in the mitochondrial electron transfer chain. It catalyses the oxidation of NADH and the reduction of ubiquinone, coupled to the translocation of protons across the mitochondrial inner membrane, maintaining the proton motive force used for ATP synthesis. Complex I is the least understood of the respiratory enzymes; although the mechanisms of NADH oxidation and intramolecular electron transfer are gradually becoming appreciated, the mechanisms of quinone binding and reduction and proton translocation remain un

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