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Dissertations / Theses on the topic 'Structural heart disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Engelman, Zoar Jacob. "Arrhythmic substrates in structural heart disease." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/9508.

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Mortality due to structural heart disease (SHD) remains high despite advances in clinical therapies. The aim of this thesis is to elucidate how structural remodeling in heart disease may lead to the development of potentially life threatening arrhythmias. This objective was advanced by the combined use of mathematical modelling and an experimental model of myocardial infarction (MI). The computer model was used to investigate possible electrical effects of tissue remodelling associated with SHD. Heterogeneous discontinuities resembling patchy fibrosis were incorporated into a 2D array o

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2

Lawley, Claire Margaret. "Outcomes in structural heart disease in New South Wales, Australia: From paediatrics to pregnancy." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20465.

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Aim To characterise and explore the contemporary outcomes at key points in the life of individuals in New South Wales (NSW), Australia, who have undergone a procedure for structural heart disease. Methods The population with structural heart disease was identified and outcomes at key points in life were evaluated using different methodologies; record linkage, retrospective cohort study and systematic review. Health and education outcomes of children with structural heart disease were evaluated via population-based record-linkage cohort studies. The role of advanced imaging methods in manag

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3

Caslake, Muriel. "Studies on the structural and metabolic heterogeneity in low density lipoprotein." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321063.

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4

Choudhary, Preeti. "Left Ventricular Non-Compaction in Congenital and Inherited Heart Disease – Structural and Functional Correlations." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18080.

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This thesis examines the structural and functional correlations of LVNC in congenital and inherited cardiac disease. LVNC is an architectural abnormality associated with heart failure, thromboembolism and arrhythmia. Current understanding is confounded by its rarity, lack of consensus on diagnostic criteria and the vast spectrum of associated abnormalities. Cardiac magnetic resonance imaging (CMR) is the gold standard for imaging myocardial architecture and function. Patients with congenital heart disease (CHD) have abnormal haemodynamics that may affect myocardial structure, both due to

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5

Pope, Adèle Joanna. "Characterising myocardial remodelling in hypertensive heart disease. Structural and functional changes in the spontaneously hypertensive rat." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/8517.

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Myocytes of varying orientation across the ventricular wall are grouped into layers, separated by cleavage planes. The role of extracellular matrix, in particular collagen, in this laminar organisation has not been fully delineated due to an inability to truly appreciate its 3D relationships. This thesis utilised an unique laser confocal scanning microscopy system to produce high resolution 3D images of normal adult rat myocardium to elucidate the arrangement of collagen with respect to myocytes. Perimysium was shown to have an ordered arrangement that played a direct role in laminar or

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6

Arya, Arash Khosrow. "Predictors of appropriate and inappropriate Therapies in Patients with implantable cardioverter-defibrillator and Structural Heart Disease." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-197732.

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Identifying factors associated with appropriate and inappropriate therapies in patients with implantable cardioverter-defibrillator (ICD) could help to identify those at risk and reduce the incidence of this emergency situation which has detrimental effect on mortality and morbidity in patients with ICD. These studies were designed to find the prevalence and factors associated with appropriate and inappropriate therapies in patients with ICD.

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7

Lin, Zin-Rong. "Developing a model of quality of life for people with coronary heart disease." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/12309.

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Quality of life (QOL) is an extremely important concept in the promotion of appropriate and successful health care programmes. However, there is a need for conceptual clarity to unravel the complexities of terminology in different medical conditions and the underlying factors that have a direct influence on the quality of life for people with coronary heart disease. The primary objective of this thesis is to propose a theoretical model which specifies the domains of QOL and the interrelationships among these domains. The objectives of the study are four-fold: (1) To examine whether a cardiac r

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8

Herman, Adam. "Etiology of cardiac arrest in the absence of manifest structural heart disease : update from the CASPER prospective cohort." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/53772.

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Background: The Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER) enrolls patients with apparently unexplained cardiac arrest and no evident cardiac disease, and aims to identify the underlying conditions responsible for the cardiac arrest through systematic clinical testing. A combination of exercise testing, drug provocation, electrophysiological testing, advanced cardiac imaging, and targeted genetic testing may unmask the cause of cardiac arrest when a cause is not apparent. Methods and Results: The first 200 survivors (48.6 ± 14.7 years, 41% female) of unexplaine

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9

DUSI, VERONICA. "Prognostic Impact of Atrial Rhythm and Dimensions in Patients with Structural Heart Disease Undergoing Cardiac Sympathetic Denervation for Ventricular Arrhythmias." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1329188.

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Background: Cardiac sympathetic denervation (CSD) is a promising treatment for patients with structural heart disease (SHD) and refractory ventricular tachyarrhythmias (VT). The prognostic impact of atrial arrhythmias (AAs) and left atrial volume index (LAVI) on CSD outcome is unknown, as is the effect of CSD on atrial rhythm. Objective: Assess the impact of AAs and LAVI on CSD outcome, as well as changes in atrial rhythm after CSD. Methods: Patients with SHD undergoing CSD for VTs were analyzed. Hazard models were built to assess predictors of sustained VT/ICD shocks and death/orthotopi

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10

Wachowiak, Paul Stephen. "Relationships among Cynical Hostility, Metabolic Syndrome, and Cardiac Structure and Function in Multi-Ethnic Post-Myocardial Infarction Patients: A Structural Modeling Approach." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/291.

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BACKGROUND: Risk factors associated with Metabolic Syndrome (MetS) have been implicated in cardiovascular disease (CVD) development and outcomes. Few studies have investigated relationships between psychological variables, MetS factors, and indices of cardiac structure and function (CSF) among healthy individuals in a single conceptual model. No studies to date have analyzed such relationships in patients with CVD. METHODS: The present study examined associations between cynical hostility (CynHo), MetS factors, and CSF in 186 multi-ethnic post-myocardial infarction (MI) patients. Structura

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11

Arya, Arash Khosrow [Verfasser], Gerhard [Akademischer Betreuer] Hindricks, Dietrisch [Gutachter] Pfeiffer, and Gerhard [Gutachter] Schuler. "Predictors of appropriate and inappropriate Therapies in Patients with implantable cardioverter-defibrillator and Structural Heart Disease / Arash Khosrow Arya ; Gutachter: Dietrisch Pfeiffer, Gerhard Schuler ; Betreuer: Gerhard Hindricks." Leipzig : Universitätsbibliothek Leipzig, 2016. http://d-nb.info/123956774X/34.

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12

Sacher, Frédéric. "Caractéristiques et traitements des cicatrices myocardiques responsables d'arythmie ventriculaire." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0032/document.

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L’ablation par radiofréquence percutanée est un des traitements des tachycardiesventriculaires (TV). Bien que salvateur chez certains patients avec myocardiopathie (MCP),les taux de succès rapportés varient de 53 à 67% dans les centres entrainés.Le but de ce travail est d’essayer de mieux comprendre le substrat des arythmiesventriculaires et d’en améliorer le traitement. Pour cela, nous avons étudié le substrat despatients adressés pour ablation de TV (sur MCP ischémique, sur MCP dilatée à coronairessaines avec cicatrices sous épicardiques, chez les patients avec assistance ventriculairegauche

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13

Hadian, Mojtaba. "Study of collagen structure in canine myxomatous mitral valve disease." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4383.

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Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans and therefore is a disease of emerging comparative interest. Realising the importance of collagen fibres in mitral heart valves and considering the paramount significance of myxomatous mitral valve disease, a better understanding of the pathogenesis of MMVD is essential. Thus, this study was designed to investigate the changes in collagen molecules, including fibril structure

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14

Grip, Björn. "Samhällsförändring och det ömtåliga hjärtat : En analys av samhälle, ohälsa och hjärtdödlighet i Linköping och Norrköping från 1950-tal till 2000-tal." Licentiate thesis, Linköpings universitet, Tema Kultur och samhälle – Tema Q, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91719.

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The study Social Change and the Fragile Heart is an analysis of contemporary history in two neighboring Swedish cities, Linköping and Norrköping. The analysis has been made from a special perspective: the changes in deaths due to heart disease in the age group 50-74 years. The differences in mortality between the two cities is a measurable way to study how well a society functions and is governed. These cities in the county of Östergötland differ historically and socially. This has led to clear differences in socio-economic conditions and even variations in health and mortality that have been

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15

Myredal, Anna. "Cardiovascular regulation and vascular structure in prehypertension and coronary heart disease /." Göteborg : Dept. of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, 2009. http://hdl.handle.net/2077/20809.

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16

Donnelly, John Leo. "The effects of hypoxia and reoxygenation on the fine structure of myocardial capillaries in relation to permeability." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243907.

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17

de, Gannes Matthew K. "Dioxin Impact on Cardiac Development, Structure, Function, and Health, and Implications for Disease." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613748020897261.

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18

Kay, Edmund. "Cardiac acoustics : understanding and detecting heart murmurs." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275992.

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19

Malyala, Sathyavani. "Effect of tissue structure (and) disease on simulated arrhythmias in the human heart." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15874/.

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Ventricular Fibrillation (VF) is a severe cardiac arrhythmia. Early experiments provided evidence that the mechanism of VF is consistent with re-entry. In 3D the sources of re-entrant waves are lines of phase singularity called ‘filaments’. Filament interactions and filament numbers can be used to quantify the complexity of activation patterns in simulated VF. The aim of this thesis is to study the effect of tissue structure, shape, initial conditions, and region of scar on filament dynamics using computational modelling. Transmural heterogeneity in 3D slab tissue representing the ventricular

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20

Hansson, Kerstin. "Diagnostic imaging of cardiopulmonary structures in normal dogs and dogs with mitral regurgitation /." Uppsala : Dept. of Biomedicine and Veterinary Public Health, Division of Diagnostic Imaging and Clinical Pathology, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/v167.pdf.

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21

Ottosson, Lars. "Molecular characterization of the Ro52 autoantigen and its disease related epitopes /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-185-7/.

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22

Grande, Kathryn Jane. "The aortic root-aortic valve relationship in the normal, diseased, and surgically repaired states /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8114.

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23

Grytsiuk, M. I. "Mortality structure and rate due to ischemic heart disease among residents of Chernivtsi region." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12159.

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24

Chatterjee, Tushar. "An individual life history model for heart disease, stroke and death : structure, parameterisation and applications." Thesis, Heriot-Watt University, 2008. http://hdl.handle.net/10399/2160.

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We have developed' a multiple - state stochastic Markov model incorporating the factors hypertension, hypercholesterolaemia, diabetes, body mass index and the events ischaemic heart disease, stroke and death. Smoking is treated deterministically in our model. The model is specified by transition intensities obtained from Framingham Heart Study data and adjusted using Health Survey for England data to produce results that are consistent with the English population. We can calculate the expected future lifetime for an individual using the model. 'In terms of the expected future lifetime we have

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25

Mottram, Philip M. "Use of new echocardiographic techniques to assess myocardial structure and function : implications for diagnosis and treatment of hypertensive heart disease and diastolic heart failure /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18687.pdf.

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26

Fathi, Robert B. "Interaction of vascular structure and function with myocardial ischaemia and survival /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17613.pdf.

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27

Morrison, Margaret Louise. "Biophysical and psychosocial wellbeing in adolescents with congenital heart disease : a structured programme of intervention and assessment." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557390.

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Ability to exercise is an important quality of life measure and indicator of physical health. Recently, exercise training has emerged as a method of improving activity and psychological health in some patient groups. Many patients with CHD are now adolescents; this time of personal development may be an ideal opportunity to introduce positive lifestyle changes. This study aimed to ascertain if motivational techniques and a structured exercise program could increase activity and improve wellbeing. Patients aged 12-20 years were identified using the Northern Ireland regional database (HeartSuite

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28

Gittins, Matthew. "Air pollution and mortality : an investigation into the lag structure between exposure to air pollution, temperature and mortality from pneumonia, chronic obstructive pulmonary disease, & ischaemic heart disease." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-and-mortality-an-investigation-into-the-lag-structure-between-exposure-to-air-pollution-temperature-and-mortality-from-pneumonia-chronic-obstructive-pulmonary-disease--ischaemic-heart-disease(b60a4e17-525b-43b3-b4e5-16ac0d768a49).html.

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Introduction: The association between daily air pollution exposure and risk of mortality is well established. Few studies have investigated in detail the associations beyond a seven day lag. The aim of this thesis was to investigate the change in risk across longer (30 day) periods post exposure for three specific causes of death: pneumonia, chronic obstructive pulmonary disease (COPD), and ischaemic heart disease (IHD). Methods: Daily Scottish mortality data (1980-2011) was matched to measurements from local fixed site pollution (Black smoke, PM10, PM2.5, SO2, & NO2) and temperature monitors.

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29

MASTROTOTARO, GIUSEPPINA. "Molecular characterization of the sarcomeric Z-line proteins nebulette and palladin in the heart: roles in cardiac structure, function, and disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94177.

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The sarcomeres are the smallest contractile units of striated muscle. It is formed by actin (thin) and myosin (thick) filaments that slide over each other during contraction and is stabilized by titin filaments, which acts as a spring during contraction. In the Z-line at the boundary between sarcomeres, actin and titin filaments are cross-linked and the contractile apparatus is connected with the cytoskeleton and extracellular matrix. The Z-line is important for efficient force generation and maintenance of cardiac structure, and is a focal point for mechanosensing and signal transduction. Con

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30

Lee, Sung Mun. "Role of aggregation conditions and presence of small heat shock proteins on abeta structure, stability and toxicity." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/3905.

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AlzheimerÂs disease (AD) is a neurodegenerative disorder that is one of such diseases associated with protein aggregation. Aβ is the main protein component of senile plaques in AD, and is neurotoxic when aggregated. In particular, soluble oligomeric forms of Aβ are closely related to neurotoxicity. In this dissertation, we examine the differences in Aβ aggregation intermediates, and final structures formed when only a simple modification in Aβ aggregation conditions is made, the presence or absence of mixing during aggregation. We show that intermediates in the aggregation pathway show signif

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31

PRADA, ARIANNA. "THREE STEPS METHOD TO SCREEN CONGENITAL HEART DISEASE AT 11-13+6 WEEKS:VALIDATION OF A NEW HIGH DEFINITION IMAGING MODE TO DETECT FETAL CARDIAC STRUCTURES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/334864.

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THREE STEPS METHOD TO SCREEN CONGENITAL HEART DISEASE AT 11-13+6 WEEKS: VALIDATION OF A NEW HIGH DEFINITION IMAGING MODE TO DETECT FETAL CARDIAC STRUCTURES Objective We designed a prospective study to test the feasibility of the first level screening for cardiac defects at the time of Nuchal Translucency (NT) measurement using a new high definition blood flow imaging mode (e-flow). We also compare the quality of first level operators visualization both with B-Mode and e-flow mode. Methods 636 consecutive fetuses between 11 and 13 + 6 weeks referred for NT at San Paolo Hospital were

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32

Yang, Hua. "Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc804879/.

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The coronary heart disease kills more than 350,000 persons/year and it costs $108.9 billion for the United States each year, in spite of significant advancements in clinical care and education for public, cardiovascular diseases (CVD) are leading cause of death and disability to the nation. A cardiovascular disease involves mainly heart or blood vessels (arteries, veins and capillaries) or both, and then mainly occurs in selected regions and affects heart, brain, kidney and peripheral arteries. As a surgical interventions, stent implantation is deployed to cure or ameliorate the disease. Howev

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33

Alleau, Thibaut. "Development of a numerical platform to model the mitral valve." Thesis, Compiègne, 2021. http://www.theses.fr/2021COMP2649.

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L’insuffisance mitrale est la valvulopathie mondiale la plus fréquente avec une prévalence de 2%. Lorsque le patient n’est pas en mesure d’être opéré à cœur ouvert, un implant percutané est utilisé pour aider la fermeture des feuillets. Le seul implant actuellement disponible est basé sur la réparation bord à bord de la valve mitrale. Il réduit le reflux vers l’oreillette lors de la systole, mais n’est pas adapté pour les patients souffrant d’insuffisance mitrale fonctionnelle, chez qui la pathologie provient du ventricule et non des éléments de la valve. L’objectif de la thèse est de fournir

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34

Mi, Xiaojuan. "Genetic applications using structural equation modeling." 2009. http://proquest.umi.com/pqdweb?did=1694433131&sid=3&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Nebraska-Lincoln, 2009.<br>Title from title screen (site viewed June 26, 2009). PDF text: vii, 120 p. : ill. ; 855 Kb. UMI publication number: AAT 3350451. Includes bibliographical references. Also available in microfilm and microfiche formats.

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35

Ha, Ji-Sook. "The role of human serum albumin and its structural variants in coronary heart disease." Thesis, 2004. http://proquest.umi.com/pqdweb?index=0&did=813797371&SrchMode=1&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1233790422&clientId=23440.

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36

Arya, Arash Khosrow. "Predictors of appropriate and inappropriate Therapies in Patients with implantable cardioverter-defibrillator and Structural Heart Disease." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A13456.

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Identifying factors associated with appropriate and inappropriate therapies in patients with implantable cardioverter-defibrillator (ICD) could help to identify those at risk and reduce the incidence of this emergency situation which has detrimental effect on mortality and morbidity in patients with ICD. These studies were designed to find the prevalence and factors associated with appropriate and inappropriate therapies in patients with ICD.

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37

Medvedev, Roman. "Structural and functional differences between cardiomyocytes from right and left ventricles in health and disease." Doctoral thesis, 2020. http://hdl.handle.net/11562/1017728.

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Several disorders including pulmonary hypertension (PH) and heart failure (HF) could lead to right ventricle (RV) hypertrophy and failure. RV failure is one of the most important prognostic factors for morbidity and mortality in these disorders. However, there is still no therapy to prevent the RV hypertrophy in PH. Treatments developed for the left ventricle (LV) failure do not improve the survival in patients with RV failure probably due to the significant differences in the chambers physiology and hemodynamic function. A better understanding of the cellular and molecular mechanisms of RV hy

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38

Nobre, Carolina Isabel Duarte. "Imagem de Fusão em Cardiologia de Intervenção." Master's thesis, 2019. http://hdl.handle.net/10316/89657.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>The number and complexity of transcatheter interventions in the treatment of structural heart diseases has been increasing in clinical practice and has been associated with the development of new imaging technologies, to make these interventions even more accurate and secure. Complementary imaging modalities are commonly used in clinical practice, but it requires an additional mental reconstruction effort by the interventional team. The concept of fusion imaging, where two different imaging modalities are

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39

Russ, Jonathan Brent. "Computational Design of Structures for Enhanced Failure Resistance." Thesis, 2021. https://doi.org/10.7916/d8-rfmz-6x23.

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The field of structural design optimization is one with great breadth and depth in many engineering applications. From the perspective of a designer, three distinct numerical methodologies may be employed. These include size, shape, and topology optimization, in which the ordering typically (but not always) corresponds to the order of increasing complexity and computational expense. This, of course, depends on the particular problem of interest and the selected numerical methods. The primary focus of this research employs density-based topology optimization with the goal of improving structura

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Chabot, Andréanne. "Le rôle de l’aldostérone sur le remodelage structurel pulmonaire et la fonction ventriculaire droite en insuffisance cardiaque congestive." Thèse, 2011. http://hdl.handle.net/1866/6295.

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INTRODUCTION : L’insuffisance cardiaque congestive (ICC) induit remodelage pulmonaire et dysfonction ventriculaire droite (VD) qui contribuent de façon importante à la morbidité/mortalité. Malgré l’efficacité prouvée, l’antagonisme des récepteurs minéralocorticoïdes est sous-utilisé en ICC et ses mécanismes d’actions demeurent incompris. Nous avons évalué si l’Aldostérone contribue au remodelage pulmonaire et à la dysfonction VD en stimulant la prolifération des myofibroblastes (MYFs) pulmonaires. MÉTHODE ET RÉSULTATS : L’étude a été réalisée chez des rats avec infarctus du myocarde (IM) de t

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