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Dissertations / Theses on the topic 'Structure Activity Relationship studies'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Just, Baringo Xavier. "Thiopeptides: Synthesis and Structure-Activity Relationship Studies." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/128268.

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The present doctoral thesis has been devoted to the development of a new synthetic strategy to obtain a new member of the thiopeptide, or thiazolyl peptide, family of antibiotics. This new member, baringolin, was isolated and characterized by the Spanish pharmaceutical company Instituto Biomar S.A. Although a structure was proposed, no stereochemical information was provided. Thus, this thesis has several objectives; first, a novel modular and straightforward strategy must be developed to achieve its total synthesis, but also to facilitate the preparation of analogues. The achievement of the t

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2

Gabrielli, William Fullard. "Structure activity relationship studies of ochratoxin A analogues." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53070.

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Thesis (MSc)--Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Mycotoxins have assumed worldwide importance due to the ubiquitous occurrence of toxigenic fungi, their infestation of plant-based foods and feeds and the subsequent economical and health impact it because of their contamination of commercial products. Ochratoxin A (OA) is a nephrotoxic mycotoxin produced by isolates of Aspergillus ochraceus and Penicillium verrucosum and occurs frequently in nature. The major target for toxicity of OA in mammalian species is the kidneys and it has been the major cause of Danish Porcine N

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3

Li, Ju-Yun. "Quantitative structure-activity relationship studies in medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062596938.

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4

Musa, Muftah Miloud A. "Structure activity relationship studies of new ethylene antagonists." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/77805.

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Ethylene antagonists provide one of the most effective methods to reduce postharvest losses of horticulture produce. The understanding of the mode of action of 1-methylcyclopropene led to the discovery of a new class of ethylene antagonist. Cycloproparenes, benzocyclopropene and 1H-naphtho[b]cyclopropene were prepared and showed excellent inhibition of the effect of ethylene on some fruits and waxflowers.

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5

Dimayuga, Mario Arnulfo De Leon. "Structure-activity relationship studies of biological activities of chemicals." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055532031.

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6

FAN, WEIGUO. "USING MOLECULAR SIMILARITY ANALYSIS FOR STRUCTURE-ACTIVITY RELATIONSHIP STUDIES." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353964351.

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7

Srivastava, Sanjay. "Structure-activity relationship studies in medicinal chemistry and drug design." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056054628.

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8

Congdon, Molly D. "Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82129.

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A variety of diseases including Alzheimer's disease, asthma, cancer, fibrosis, multiple sclerosis, and sickle cell disease have been associated with elevated levels of sphingosine-1-phosphate (S1P). S1P, a pleiotropic lipid mediator involved in a broad range of cellular processes, is synthesized solely by the phosphorylation of sphingosine (Sph) and is catalyzed by the two isoforms of sphingosine kinase (SphK1 and SphK2). Therefore, SphKs are a potential therapeutic target; however, the physiological role of SphK2 is still emerging. In order to determine the role of SphK2 in vivo, more potent

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9

Ptchelintsev, Dmitri Stanislav. "Structure-activity relationship studies in chemoreception, toxicology and medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060866168.

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10

Davies, Rachel A. "Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5953.

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Synthetic cathinones and related agents represent an international drug abuse problem, and at the same time an important class of clinically useful compounds. Structure-activity relationship studies are needed to elucidate molecular features underlying the pharmacology of these agents. Illicit methcathinone (i.e., MCAT), the prototype of the synthetic cathinone class, exists as a racemic mixture. Though the differences in potency and target selectivity between the positional and optical isomers of synthetic cathinones and related agents have been demonstrated to have important implications for

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11

Bourin, Marie-Claude. "Thrombomodulin: a novel proteoglycan : studies on structure-function relationships /." Uppsala : Sveriges lantbruksuniv, 1990. http://epsilon.slu.se/avh/1990/91-576-4149-8.gif.

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12

Shi, Zhen. "Heme biosynthesis: structure-activity studies of murine ferrochelatase." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001450.

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13

Childress, Elizabeth Saunders. "Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86662.

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Sphingosine 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease. It is formed from the phosphorylation of sphingosine (Sph) by sphingosine kinase (SphK) and SphK exists as two isoforms-"SphK1 and SphK2, which differ with respect to their cellular activity and localization. As the key mediators in the synthesis of S1P, SphKs have attracted attention as viable targets for pharmaceutical inhibition. To validate their potential as therapeutic targets, we aimed to develop potent, select

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14

Prince, Maureen J. "Structure activity relationship studies of inhibitors of industrially and medicinally important enzymes." Thesis, University of Canterbury. Chemistry, 1999. http://hdl.handle.net/10092/6673.

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This thesis presents the results of structure-activity relationship (SAR) studies on inhibitors of two important enzymes: alpha-amylase and steroid 5α-reductase. Ascorbic acid, a reported inhibitor of alpha-amylase, has been investigated to determine which of its structural features are necessary for its inhibitory action. These studies have involved the synthesis of thirteen derivatives of L-ascorbic acid and three derivatives of D-isoascorbic acid, incorporating systematic modifications of the functional groups present in both molecules. We have found that the ene-diol moiety in ascorbic ac

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15

Morris, Emily A. "Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73491.

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Sphingosine 1-phosphate (S1P) has become a prevalent drug discovery target due to studies implicating it to several disease pathologies such as fibrosis, sickle cell disease, inflammation, diabetes, and cancer. S1P functions to induce cell proliferation and migration. S1P signaling occurs through intracellular targets or transport outside of the cell via ABC transporters, where it acts as a ligand to G-protein coupled receptors (S1P1-5). Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to S1P; these are the only enzymes known to mediate the phosphoryl transfer. Inhibiting either

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16

DeBord, Michael. "Synthesis, characterization, and anti-cancer structure-activity relationship studies of imidazolium salts." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1489414733025495.

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17

Jinno, Shuji. "Studies on Synthesis and Structure-Activity Relationship of Phenolic Antioxidants of Yeasts." Kyoto University, 1999. http://hdl.handle.net/2433/181405.

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18

Hattotuwagama, Channa Karunadasa. "Computational studies of sweet-tasting molecules." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270841.

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19

Rylands, Laa-iqa. "Structure-activity relationship studies of 2-phenylbenzimidazoles and related organometallic complexes as antiplasmodial agents." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29418.

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Malaria remains a huge public health concern, affecting millions of people from all around the world. The widespread resistance by Plasmodium parasites to previously effective quinoline-based drugs and the emerging resistance to current antimalarial therapies, stresses the urgent need for the exploration and development of diverse new classes of compounds. Amongst other requirements, these diverse new compound classes should target resistant strains in particular. In this regard, benzimidazoles have been identified as promising potential drug candidates, displaying potent antiplasmodial activi

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20

De, Cecco Martin. "Biophysical studies to elucidate structure-activity relationships in β-defensins". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4931.

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β-defensins are a class of mammalian defence peptides with therapeutic potential because of their ability to kill bacteria and attract host immune cells. In order to realise this potential, it is necessary to understand how the functions of these peptides are related to their structures. This thesis presents biophysical analysis of β- defensins and related peptides in conjunction with biological assays. These studies provide new insights into the structure-activity relationships of β-defensins. Ion mobility-mass spectrometry (IM-MS) is used throughout this thesis to probe the tertiary structur

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21

Wang, Haiyao. "Antiplasmin the main plasmin inhibitor in blood plasma : studies on structure-function relationships /." Stockholm : Department of Surgical Sciences, Division of Clincal Chemistry and Blood Coagulation, Karolinska University, 2005. http://diss.kib.ki.se/2005/91-7140-278-0/.

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22

Hanaki, Yusuke. "Structure-Activity Studies on the Simplified Analog of Aplysiatoxin and Identification of the PKC Isozymes Involved in Its Anti-Proliferative Activity." Kyoto University, 2018. http://hdl.handle.net/2433/232354.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21153号<br>農博第2279号<br>新制||農||1059(附属図書館)<br>学位論文||H30||N5127(農学部図書室)<br>京都大学大学院農学研究科食品生物科学専攻<br>(主査)教授入江一浩, 教授保川清, 教授橋本渉<br>学位規則第4条第1項該当

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23

Meaney, Steve. "Studies on oxysterols : origins, properties and roles /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-635-9.

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24

Jaafar, Mohd Zuli. "Chemometrics and pattern recognition methods with applications to environmental and quantitative structure-activity relationship studies." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541608.

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25

Nadas, Janos Istvan. "Computational Structure Activity Relationship Studies on the CD1d/Glycolipid/TCR Complex using AMBER and AUTODOCK." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1251145085.

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26

Chakaingesu, Chikomborero. "Synthesis and structure-activity relationship studies of 1,4-naphthoquinone derivatives as potential anti-trypanosomal agents." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020959.

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Human African Trypanosomiasis (HAT) is an infectious, vector-borne protozoal disease which is amongst the so-called neglected diseases. In 2000, at a summit of the United Nations, eight Millennium Development Goals (MDGs) were set, to be achieved by 2015. MDG 6 states “to combat HIV/AIDS, malaria & other diseases”. With just under 2 years to go before the end of 2015, HAT is still thriving in developing countries. The drugs currently used for the treatment of HAT are in short supply, have severe side effects and those used to treat late stages of the disease are very difficult to administer. T

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27

Pan, Wenhui. "Isolation, identification, bioactivity evaluation and structure-activity relationship studies of tricothecenes and the miliusa constituents." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/547.

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Background: Natural products have attracted high attention due to their great contribution in drug discovery. Many natural products have shown to be effectively against different disease targets including cancer, malaria and HIV. And their structural diversity is a rich resource for the discovery of novel bioactive compounds. This thesis is to explore plant natural products for their potential in treatment of malaria and cancer diseases. Malaria is still considered as a major global health problem, affecting a large population of the world, especially in the developing countries. Effective dru

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28

Shalabi, Abdelrahman R. "Structure-Activity Relationship Studies of Bupropion and Related 3-Substituted Methcathinone Analogues at Monoamine Transporters." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5176.

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The khat plant, catha edulis, has been abused for some time in the Middle East and the African horn for its short-term stimulant effects. However, it was not until 1975 when cathinone, β-ketoamphetamine, was identified as the major stimulant component of khat. Structural analogues of cathinone, synthetic cathinones, are new psychoactive substances available on the clandestine market of numerous countries including the USA. Abuse of these new illicit stimulants is a worldwide growing health concern which necessitates the investigation of the pharmacological properties of these new drugs of abus

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29

MilitÃo, GardÃnia Carmen Gadelha. "Antitumor potential of flavonoids derived from northeastern brazilian plants: preliminary studies on structure-cytotoxic activity relationship." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=100.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>In searching for anticancer compounds derived from plant sources, 18 flavonoids were assayed for their cytotoxic potentials and the results were compared for structure-activity relationship purposes. The flavonoid group was subdivided in flavones and pterocarpans. The cytotoxic activity was initially evaluated on tumor cell lines, through the MTT assay, and on sea urchin eggs development. The pterocarpans showed a consistently higher activity on both assays. For the flavones, some structure-activity observations can be highlighted:

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30

Abdurahman, Samir. "Studies on HIV-1 core assembly /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-363-4/.

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31

Aoyama, Yasunori. "Studies on the Synthesis and Structure-Activity Relationships of Human Chymase Inhibitors." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150301.

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32

Van, Horn Kurt Steven. "Anti-parasitic and anti-bacterial agents: Studies on 1,4-dihydropyridines and 2,4-diaminoquinazolines." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4784.

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Thirty-three 1,4-dihydropyridine diastereomeric pairs were synthesized and the structure-activity relationship studied in a Plasmodium falciparum in vitro model. Twenty-nine of these derivatives contained a 6-position oxygen, with 2.31, 2.32, 2.52 and 2.53 having single and double digit nanomolar activities. This SAR study revealed some insightful information about the 1,4-dihydropyridine substitution pattern. Substitution at the 7-position other than 3,4-dimethoxy severely reduced the activity. 4-phenyl substitution with 2- or 4- halo or methyl formed active compounds while substitution at th

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33

Goff, Randal Donald. "Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/942.

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Glycosphingolipids (GSLs), composed of a polar saccharide head and a lipophilic ceramide tail, are ubiquitous components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event is mediated by CD1d, a major histocompatibility complex-like protein ex

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34

Ma, Zhidong. "Structure-activity relationship studies of hybrid antitumor agents for the treatment of non-small cell lung cancer." Winston-Salem, NC : Wake Forest University, 2009. http://dspace.zsr.wfu.edu/jspui/handle/10339/45686.

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35

Sarwar, Md Shahid. "Elucidation of anticancer efficacy of ent-kaurane diterpenes through structure-activity relationship and mechanism of action studies." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/669.

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Colorectal cancer (CRC) is the third most prevalent and second leading causes of cancer-associated deaths globally. Over the last few decades, ent-kaurane diterpenes have been widely investigated for their anticancer potentials. Flexicaulin A (9) is a naturally occurring ent-kaurane. Previously, our lab modified the structure of 9 by replacing the C-11 hydroxyl group with carbonyl group and obtained a novel compound oxoflexicaulin A (11). However, anticancer activities and mechanistic pathway of these two compounds are yet to be explored. In the current thesis, we evaluated the cytotoxicity of

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36

Chisanga, Kelly. "Synthesis, structure-activity relationship and solubility improvement studies of potential antimalarial and antischistosomal pyrido[1,2-a]benzimidazoles." Master's thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31534.

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In 2016, 216 million malaria cases with 445,000 associated deaths were recorded according to the World Health Organization (WHO). Schistosomiasis also remains a public health issue with 207 million cases recorded globally and 280,000 deaths in the same year. Widespread emergence of parasite resistance to once-effective antimalarial options has rendered currently used drugs ineffective. Moreover, the current WHO-recommended first-line antimalarial drugs in clinical use, the artemisinin combination therapies (ACTs) are faced with the challenges of limited availability, unaffordable cost, and und

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37

Johnston, Heather Jennifer. "Development of novel analogues of the anti-proliferative marine natural product bisebromoamide : synthesis and structure activity relationship studies." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17617.

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The linear peptide bisebromoamide was isolated by the Suenaga group in 2009 from the marine cyanobacterium Lyngbya sp. It exhibits antiproliferative activity at nanomolar levels against a wide range of cell lines. Current SAR data indicates that there is some flexibility in the structure with respect to stereochemistry, but the range of modifications that have been biologically tested is limited, as reviewed in Chapter 1. Bisebromoamide contains a number of non-commercial amino acids and an oxopropyl pyrrolidine moiety which had not been found in a natural product previously. Several new synth

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38

Mohlala, Reagan Lehlogonolo. "Synthesis,characterisation and biological activity studies of organo-bridged metal schiff base complexes with qinoxaline derivative." Thesis, University of Limpopo, 2016. http://hdl.handle.net/10386/1706.

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Thesis (M.Sc.(Chemistry)) -- University of Limpopo, 2016<br>Imidazolyl-salicylaldemine Schiff base ligands were prepared by the condensation of different substituted salicylaldehydes with histamine dihydrochloride: 2,4-di-tert-butyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol L1; 4-methoxy-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol L2; 2-ethoxy-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl]-phenol L3; 2-methyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol L4; 3-methyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol L5; 4-methyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-meth

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39

Suzuki, Yamato. "Diversity-Oriented Syntheses of Fused Nitrogen Heterocycles and Their Application to the Structure-Activity Relationship Studies on CK2 Inhibitors." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157893.

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40

Böhm, Miriam [Verfasser]. "Targeting the Final Step of Blood Coagulation : Structure-Activity-Relationship Studies on the Factor XIIIa Inhibitor Tridegin / Miriam Böhm." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077290438/34.

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41

Gessner, Richard Klaus. "Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/6308.

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Includes abstract.<br>Includes bibliographical references (p. 205).<br>Some 12-16 hours after the invasion of the human erythrocyte by the malaria parasite Plasmodium falciparum, there appear in the erythrocyte membrane ‘new permeability pathways’ which mediate an increased permeability of the infected cell to a range of low molecular weight solutes, including anions, cations, amino acids, polyols and nucleosides. There is evidence that the pathways have an important bi-functional role: firstly, that the new permeability pathways are required for the uptake of essential nutrients, and secondly

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42

Azizeh, Bassem Yousef. "Structure-activity relationship analysis: Developing glucagon agonists and antagonists for studies of glucagon action in normal and diabetic states." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282252.

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Several glucagon analogues containing substitutions in the N-terminal region, in particular residues 1, 5, 6, 9 and 10 (histidine, threonine, phenylalanine, aspartic acid and tyrosine, respectively), were synthesized. In addition four β-methylphenylalanine isomers were introduced at position ten to assess the role of these topographical modifications on hormone activity, and to study the effect of constraint and biased conformational preferences of the side chain moieties on biological activity. All the analogues were synthesized by solid-phase methodology, purified to homogeneity by reverse-p

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43

Hansen, Mats. "Internalization mechanisms of cell-penetrating peptides : structure-activity relationships, cellular distribution and membrane toxicity studies /." Stockholm : Department of Neurochemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7391.

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44

Rudberg, Peter C. "Leukotriene A4 hydrolase : studies of structure-function relationships by site-directed mutagenesis and X-ray crystallography /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-038-9/.

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Senthil, Vijayalakshmi. "Structure, activity and relationship studies of peptide and non-peptide analogs with secretin receptor : in search of agonist and/or antagonist." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207206.

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Class B GPCRs are emerging target in drug research. Currently these receptors serve as drug targets for several drug discovery companies and more than 50 percent of the drugs in the market targets GPCRs. Secretin receptor is found to be expressed in various tissues. Secretin regulates many bodily functions from energy to water homeostasis through both central and peripheral system. Though it holds a history of 100 years, the major drawback is its structural insights. In evidence of its integrated role in physiology as a potential target, the lookout for a novel agonist and / or antagonist for

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46

Minta, Ewelina. "Synthesis and structure-activity relationship of peptidic analogues of omega-agatoxin IVB, pharmacological toll in cognition studies : towards calcium channel modulators." Montpellier 2, 2006. http://www.theses.fr/2006MON20072.

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Ce manuscript décrit la synthèse et l'évaluation biologique d'analogues de l'w-agatoxine IV B dans le but de trouver de nouveaux outils pour l'étude de l'activité de canaux calciques. L'w-agatoxine IV B est une neurotoxine peptidique isolée du venin d'araignée Agelenopsis aperta qui à ce jour est l'inhibiteur spécifique et sélectif des canaux calciques de type P (avec l'w-agatoxine IV A). Les canaux calciques de type P sont les canaux dépendant du voltage impliqués dans la neurotransmission dépendante du Glutamate dans le système nerveux central. La synthèse de structures peptidiques simplifié

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47

Dedek, Matthew Milan. "The Melanocortin System: Structure Activity Relationships of Alpha-N-Methylated MT-II Analogues and Mutation Studies of Human Melanocortin Receptor Subtypes 1 and 4." Thesis, The University of Arizona, 2007. http://hdl.handle.net/10150/193306.

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The melanocortin system regulates various physiological processes including feeding behavior, sexual function, skin pigmentation and photoprotection via five G-protein coupled receptors and several endogenous ligands. There is a need for selective and potent ligands to the human melanocortin receptors (hMCRs) that can chemically resolve these various functions. This thesis presents three studies aimed at refining the understanding of the structural differences between binding pockets of the hMCR subtypes. In the first study α-N-methylated analogues of the non-selective agonist, MT-II, are eval

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48

Hirschberg, Daniel. "Sample preparation and mass spectrometry in proteome studies /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-934-x/.

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49

Alteen, Matthew. "Investigating the Importance of Electronic and Hydrophobic Effects for Ice Recrystallization Inhibition Using 'Beta'-'O'-Aryl Glycosides." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30335.

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The cryopreservation of cells and tissues requires the addition of a cryoprotectant in order to prevent cellular damage caused by ice. Unfortunately, common cryoprotectants such as DMSO and glycerol exhibit significant toxicity which makes their use unfeasible for many clinical procedures. Our laboratory is interested in the development of alternative, non-toxic cryoprotectants which possess ice recrystallization inhibition (IRI) activity. Potent IRI activity has recently been discovered in certain small molecules, but the structural features required for this process are unclear. Herein we

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50

Chiva, Rodriguez Ana. "Studies on the characterisation of the catalytic activity of polyclonal hydrolytic antibodies and its relationship with the haptenic structures." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410003.

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