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Dissertations / Theses on the topic 'Structure-activity relationship'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Just, Baringo Xavier. "Thiopeptides: Synthesis and Structure-Activity Relationship Studies." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/128268.

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The present doctoral thesis has been devoted to the development of a new synthetic strategy to obtain a new member of the thiopeptide, or thiazolyl peptide, family of antibiotics. This new member, baringolin, was isolated and characterized by the Spanish pharmaceutical company Instituto Biomar S.A. Although a structure was proposed, no stereochemical information was provided. Thus, this thesis has several objectives; first, a novel modular and straightforward strategy must be developed to achieve its total synthesis, but also to facilitate the preparation of analogues. The achievement of the t
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2

Tomita, Kenji. "Structure-activity Relationship Study on GPR54 Agonists." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124039.

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3

Dale, Clare Louise. "Fluorescent A₁-adenosine agonists : a structure activity relationship." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440124.

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4

Gabrielli, William Fullard. "Structure activity relationship studies of ochratoxin A analogues." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53070.

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Thesis (MSc)--Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Mycotoxins have assumed worldwide importance due to the ubiquitous occurrence of toxigenic fungi, their infestation of plant-based foods and feeds and the subsequent economical and health impact it because of their contamination of commercial products. Ochratoxin A (OA) is a nephrotoxic mycotoxin produced by isolates of Aspergillus ochraceus and Penicillium verrucosum and occurs frequently in nature. The major target for toxicity of OA in mammalian species is the kidneys and it has been the major cause of Danish Porcine N
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5

Li, Ju-Yun. "Quantitative structure-activity relationship studies in medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062596938.

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6

Oosting, Peter. "Bicyclic Tramadol analogues : towards a structure-activity relationship." Bordeaux 1, 2007. http://www.theses.fr/2007BOR13413.

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Le traitement de la douleur est un domaine d'importance croissante dans la médecine. Pour les douleurs sévères, les opiacés restent parmi les médicaments les plus utilisés, mais ils présent cependant des effets secondaires sérieux, c'est pourquoi les chercheurs continuent à développer de nouveaux analgésiques. Le Tramadol, un opiacé partiel avec un mécanisme particulier, n'induit pas les effets secondaires associés avec la plupart des opiacés. Il a été utilisé durant des années pour le traitement des douleurs modérées et sévères. Cette thèse décrit la synthèse de composés dérivés du Tramadol,
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7

Musa, Muftah Miloud A. "Structure activity relationship studies of new ethylene antagonists." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/77805.

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Ethylene antagonists provide one of the most effective methods to reduce postharvest losses of horticulture produce. The understanding of the mode of action of 1-methylcyclopropene led to the discovery of a new class of ethylene antagonist. Cycloproparenes, benzocyclopropene and 1H-naphtho[b]cyclopropene were prepared and showed excellent inhibition of the effect of ethylene on some fruits and waxflowers.
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8

Dimayuga, Mario Arnulfo De Leon. "Structure-activity relationship studies of biological activities of chemicals." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055532031.

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9

Fontaine, Jean Gonzague. "Inhibition of HSP90 with pochoximes : structure-activity relationship and structure-based insights." Strasbourg, 2010. http://www.theses.fr/2010STRA6030.

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Les protéines de choc thermique sont essentielles au maintien de l’activité cellulaire, par leur implication dans la stabilisation de leurs protéines clientes. En raison de ce rôle clef, elles sont directement impliquées dans de nombreuses affections comme le cancer, le diabète et les processus inflammatoires. L’identification de plusieurs inhibiteurs de la protéine de choc thermique de 90kDa (HSP90), par un mode d’action unique (inhibition de la poche ATPase) permis le développement d’une nouvelle classe d’anticancéreux. La geldanamycin et le radicicol, deux composés naturels ont Eté instrume
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10

Malet, Nicolas. "Structure-activity relationship and biosynthesis of the methylenomycin furans." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/54119/.

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Today, more than 70 % of clinically-used antibiotics are produced by Streptomyces species. However, it is estimated that only 1 % of secondary metabolites produced by these bacteria have been discovered to date. Chemical communication in bacteria is defined as producing and responding to signalling molecules, which govern physiological processes, including antibiotic production and morphological differentiation. By understanding the signalling mechanisms of such molecules, new bioactive metabolites, of value to society, can be discovered. Examples of well characterized signalling molecules inc
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11

Reddy, Badinehal Asrith. "COMMERCIALIZATION OF A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP TOOL - SARCHITECT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295637833.

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12

FAN, WEIGUO. "USING MOLECULAR SIMILARITY ANALYSIS FOR STRUCTURE-ACTIVITY RELATIONSHIP STUDIES." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353964351.

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13

Longworth, Mitchell Francis. "Structure Activity Relationship Study of Cannabinoid Receptor 1 Ligands." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18242.

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This thesis describes the design, synthesis and pharmacological evaluation of a library of CB1 orthosteric and allosteric ligands. Synthetic cannabinoids (SCs) have emerged in the public domain as a ‘legal’ alternative to cannabis. These drugs are based on experimental cannabinoid 1 receptor (CB1) agonists that were investigated as potential treatments for neuropathic pain. As these compounds have not gone through any formal human testing, they have been associated with an array unpredictable, and often serious, adverse effects. The initial focus of this work was to synthesise recent high con
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14

Gupta-Ostermann, Disha [Verfasser]. "Computational Methods for Structure-Activity Relationship Analysis and Activity Prediction / Disha Gupta-Ostermann." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080561277/34.

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15

Srivastava, Sanjay. "Structure-activity relationship studies in medicinal chemistry and drug design." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056054628.

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16

Congdon, Molly D. "Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82129.

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A variety of diseases including Alzheimer's disease, asthma, cancer, fibrosis, multiple sclerosis, and sickle cell disease have been associated with elevated levels of sphingosine-1-phosphate (S1P). S1P, a pleiotropic lipid mediator involved in a broad range of cellular processes, is synthesized solely by the phosphorylation of sphingosine (Sph) and is catalyzed by the two isoforms of sphingosine kinase (SphK1 and SphK2). Therefore, SphKs are a potential therapeutic target; however, the physiological role of SphK2 is still emerging. In order to determine the role of SphK2 in vivo, more potent
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17

Akester, Jessica Nicole. "Synthesis, structure-activity relationship and solubility profiling of antimycobacterial aminoquinazolinones." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24998.

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Tuberculosis (TB) is a communicable disease caused by an infectious bacterial pathogen called Mycobacterium tuberculosis (Mtb), which is acquired through the inhalation of bacilli-containing droplets. With the emergence of resistant strains (multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and totally drug-resistant TB (TDR-TB)), co-infection with human immunodeficiency virus (HIV), the existence of latent TB infection (LTBI) and the extensive treatment regimen resulting in poor patient compliance, there is therefore a need to develop novel antimycobacterial agents to ad
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18

Ptchelintsev, Dmitri Stanislav. "Structure-activity relationship studies in chemoreception, toxicology and medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060866168.

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19

Ling, Chen. "Structure-Activity Relationship of Hydroxyapatite-binding Peptides for Biomimetic Mineralization." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1461849773.

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20

Davies, Rachel A. "Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5953.

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Synthetic cathinones and related agents represent an international drug abuse problem, and at the same time an important class of clinically useful compounds. Structure-activity relationship studies are needed to elucidate molecular features underlying the pharmacology of these agents. Illicit methcathinone (i.e., MCAT), the prototype of the synthetic cathinone class, exists as a racemic mixture. Though the differences in potency and target selectivity between the positional and optical isomers of synthetic cathinones and related agents have been demonstrated to have important implications for
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21

Bagchi, Bhaskar. "Quantum chemical calculation and structure activity relationship of bioactive terpenoids." Thesis, University of North Bengal, 2016. http://ir.nbu.ac.in/handle/123456789/2762.

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22

Nilsson, Ulrika K. "Lysophosphatidic acid : Physiological effects and structure-activity relationships." Doctoral thesis, Linköping : Univ, 2002. http://www.ep.liu.se/diss/med/07/51/index.html.

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23

Bourin, Marie-Claude. "Thrombomodulin: a novel proteoglycan : studies on structure-function relationships /." Uppsala : Sveriges lantbruksuniv, 1990. http://epsilon.slu.se/avh/1990/91-576-4149-8.gif.

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24

Childress, Elizabeth Saunders. "Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86662.

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Sphingosine 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease. It is formed from the phosphorylation of sphingosine (Sph) by sphingosine kinase (SphK) and SphK exists as two isoforms-"SphK1 and SphK2, which differ with respect to their cellular activity and localization. As the key mediators in the synthesis of S1P, SphKs have attracted attention as viable targets for pharmaceutical inhibition. To validate their potential as therapeutic targets, we aimed to develop potent, select
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25

Biwi, James Tapiwa. "A Structure-Activity Relationship Study of Dihydroajoenes as Anti-Cancer Agents." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12826.

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Includes bibliographical references.<br>Ajoene (( E-/Z )-4,5,9-trithiadodeca-1,6,11-triene-9-oxide), a constituent of garlic is known to possess in vitro and in vivo anticancer activity based on the presence of a vinyl disulfide as its pharmacophore. This thesis reports on the synthesis of dihydroajoenes, a novel set of ajoene analogues, containing a saturated double bond, in which the intention was to study the influence of removing the double bond on biological activity and metabolic stability, since ajoenes are unstable in blood. A divergent synthetic route to 6 new dihydroajoene analogues
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26

Morisse, Clément. "The structure/activity relationship of nitrobenzene hydrogenation over Pd/alumina catalysts." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6384/.

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The hydrogenation of nitrobenzene to form aniline is a large-scale industrial process performed using a variety of heterogeneous catalysts. One variant of the process involves the application of alumina-supported Pd catalysts. Although several 0.3 wt% Pd/alumina formulations exhibit high aniline selectivity (ca. 98%), different grades of these catalysts favour different impurities. It is observed that the impurities arise from different reaction pathways depending on the provenance of the catalyst. In order to investigate whether the origins of impurity formation are connected to catalyst stru
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27

Yadav, Barkha J. "UNDERSTANDING STRUCTURE-ACTIVITY RELATIONSHIP OF SYNTHETIC CATHINONES (BATH SALTS) UTILIZING METHYLPHENIDATE." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5955.

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Synthetic cathinones are stimulant drugs of abuse that act at monoamine transporters e.g. the dopamine transporter (DAT) as releasing agents or as reuptake inhibitors. More than >150 new synthetic cathinones have emerged on the clandestine market and have attracted considerable attention from the medical and law enforcement communities. threo-Methylphenidate (tMP) is an FDA approved drug for the treatment of ADHD and narcolepsy, which also acts as a DAT reuptake inhibitor and is widely abused. tMP and synthetic cathinones share some structural similarities and extensive structure-activity rela
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28

Li, Hao. "Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/100741.

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Sphingosine kinase 1 (SphK1) is the key enzyme catalyzing the formation of sphingosine-1-phosphate (S1P), which is an important signaling molecule that regulates multiple biological process including inflammatory responses. Elevated SphK1 activity as well as upregulated S1P levels is linked to various diseases such as cancer, fibrosis and sickle cell disease. Therefore, there is a growing interest in studying SphK1 as a potential target for these diseases. Through high-throughput screening, various SphK1 inhibitors have been discovered, among which PF-543 is the most potent and selective inhib
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29

Shi, Zhen. "Heme biosynthesis: structure-activity studies of murine ferrochelatase." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001450.

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30

Nahas, Roger I. "Synthesis and structure-activity relationship of a series of sigma receptor ligands." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4840.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.
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31

Ren, Xin. "Quantitative structure-activity relationship based virtual screening for novel androgen receptor antagonists." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43293.

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Androgen receptor (AR) plays a critical role in prostate cancer development and progression. All current therapeutic AR inhibitors modulate the receptor via direct binding to its Hormone Binding Site (HBS). Despite the identification of other small molecule binding areas on the AR surface including Activation Function 2 (AF2), binding function 3 (BF3), and N-terminal domain (NTD), HBS continues to be the major target site for AR antagonists (even though this site is prone to resistant mutations). Thus, there is a high need for the identification and development of novel antagonists targeting H
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32

Čapkauskaitė, Edita. "Synthesis of carbonic anhydrase inhibitors and analysis of their structure - activity relationship." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20121211_095540-78760.

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The aim of this work was formulated - the synthesis of potent human carbonic anhydrase inhibitors, and their structure - activity study. The synthesized 136 new compounds were subjected to the studies of their inhibitory activity towards CA I, II, VII, XII and XIII (VU IBT). An efficient method for N-and S-alkylation of heterocyclic compounds (benzimidazole), S-alkylation of heterocyclic and aromatic compounds (imidazole, benzothiazole, benzimidazothiadiazole, pyrimidine, benzenethiol) with 3 - and 4 - (bromoacetyl)benzenesulfonamides and 4 - and 5 - (bromoacetyl)-2-chlorobenzenesulfonamides h
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33

Iyer, Preeti Ramesh [Verfasser]. "Multi-faceted Structure-Activity Relationship Analysis Using Graphical Representations / Preeti Ramesh Iyer." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1048091465/34.

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34

Prince, Maureen J. "Structure activity relationship studies of inhibitors of industrially and medicinally important enzymes." Thesis, University of Canterbury. Chemistry, 1999. http://hdl.handle.net/10092/6673.

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This thesis presents the results of structure-activity relationship (SAR) studies on inhibitors of two important enzymes: alpha-amylase and steroid 5α-reductase. Ascorbic acid, a reported inhibitor of alpha-amylase, has been investigated to determine which of its structural features are necessary for its inhibitory action. These studies have involved the synthesis of thirteen derivatives of L-ascorbic acid and three derivatives of D-isoascorbic acid, incorporating systematic modifications of the functional groups present in both molecules. We have found that the ene-diol moiety in ascorbic ac
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35

Smith, Mark David. "A quantitative structure-activity relationship (QSAR) study of the Ames mutagenicity assay." Thesis, University of Portsmouth, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343333.

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In-vitro mutagenicity assays have traditionally been used for first line identification of potential genotoxic hazard, purporting to chemical carcinogenesis and heritable genetic damage. The recent advances m combinatorial chemistry and high throughput screening technologies have led to a massive explosion in numbers of possible therapeutic candidates being produced at the early stages of drug discovery. This rapid increase in the number of chemicals to be classified results in a greater need for to acquire alternative methods for the prediction of toxicity. Quantitative StructureActivity Rela
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36

Morris, Emily A. "Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73491.

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Sphingosine 1-phosphate (S1P) has become a prevalent drug discovery target due to studies implicating it to several disease pathologies such as fibrosis, sickle cell disease, inflammation, diabetes, and cancer. S1P functions to induce cell proliferation and migration. S1P signaling occurs through intracellular targets or transport outside of the cell via ABC transporters, where it acts as a ligand to G-protein coupled receptors (S1P1-5). Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to S1P; these are the only enzymes known to mediate the phosphoryl transfer. Inhibiting either
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37

DeBord, Michael. "Synthesis, characterization, and anti-cancer structure-activity relationship studies of imidazolium salts." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1489414733025495.

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38

Sterby, Mia. "Dissecting the Structure-Activity Relationship of Hairpinin, a Plant Derived Antimicrobial Peptide." Thesis, Uppsala universitet, Avdelningen för farmakognosi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-226582.

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Antibiotic resistance is a growing health issue that necessitates development of alternative drugs with antimicrobial properties. Antimicrobial peptides are a promising group of compounds in this respect and are used by all varieties of living organisms to defend against invading or competing organisms. Hairpinin is an antimicrobial peptide isolated from Echinochloa crus-galli that has previously been found to have antifungal activity. In this study, truncated variants of hairpinin were synthesized and their antifungal activity tested against Candida albicans, Aspergillus fumigatus, and Saccha
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39

Jinno, Shuji. "Studies on Synthesis and Structure-Activity Relationship of Phenolic Antioxidants of Yeasts." Kyoto University, 1999. http://hdl.handle.net/2433/181405.

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40

Dannoon, Shorouk Lewis Michael R. Jurisson Silvia. "Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/7019.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 25, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Silvia Jurisson and Dr. Mike Lewis. Vita. Includes bibliographical references.
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41

Mastronardi, F. "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW SUBTYPE SELECTIVE KAINATE RECEPTOR LIGANDS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/252272.

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Glutamate receptors are the principal mediators of the excitatory transmission in the CNS. These proteins are divided into two big families: metabotropic and ionotropic receptors (mGluRs and iGluRs). Among iGluRs, kainate receptors (KARs) are of remarkable interest because they have a modulatory role and, for this reason, they could be ideal drug targets. Moreover, since kainate receptors are formed by five different type of subunits (GluK1-5) and each of them seems to be related to different neorological disorder, is much more fascinating to search for subunit-selective compounds. On this g
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42

Barber, Megan Marie. "2,4-Disubstituted Quinazolines with Antileishmanial or Antibacterial Activity." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5840.

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Herein 47 2,4-disubstituted quinazolines were synthesized and tested against Leishmania donovani intracellular amastigotes. A structure-activity relationship was conducted and lead to the identification of quinazolines with EC50s in the single digit and high nanomolar range with favorable antileishmanial selectivity indexes. Quinazoline 2.6 and 2.31 underwent in vivo efficacy studies in murine models of visceral leishmaniasis, reducing liver parasitemia by 12 % and 24 %, respectively, when given by the intraperitoneal route at 15 mg/kg/day x 5 days. The antileishmanial efficacy and easy of syn
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43

Pandit, Bulbul. "Study of structure activity relationship of analogs derived from SU-5416 and thalidomide and mechanism of antiproliferative activity." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187127289.

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44

Strömberg, Patrik. "Identification and characterization of novel mammalian alcohol dehydrogenases /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-312-0.

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45

Skytte, Dorthe. "Antimalarial norneolignans, synthesis and SAR & synthesis of beta-lactams /." Cph. : Danish University of Pharmaceutical Sciences, Department of Medicinal Chemistry, 2005. http://www.dfuni.dk/index.php/Dorthe_Mondrup_Skytte/2238/0/.

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46

Griffin, Shane G., of Western Sydney Hawkesbury University, and of Science Technology and Agriculture Faculty. "Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure." THESIS_FSTA_XXX_Griffin_S.xml, 2000. http://handle.uws.edu.au:8081/1959.7/243.

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Although the antomicrobial nature of essential oils and their major constituents, the terpenoids, has been widely investigated the mechanism of their antimicrobial action has not been subject to the same scrutiny. In this study the membrane disruptive nature of the terpenoids has been determined by experiments on the effects of terpenes on both microbial membrane and model lipid bilayer systems. These terpenes exhibited a range of membrane damaging effects. Experiments showed that the terpenoids were able to increase disorder in DPPC bilayers, and that antimicrobially active terpenoids cause i
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47

Griffin, Shane. "Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure /." View thesis View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030429.142248/index.html.

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48

Lanevskij, Kiril. "Absorption and Tissue Distribution of Drug-Like Compounds: Quantitative Structure-Activity Relationship Analysis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114235-89858.

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The objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lip
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49

Psakis, Georgios. "The D-galactose-H⁺ symporter (GaIP) from Escherichia coli : structure-activity relationship." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414216.

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50

Harris, Suzanne. "Exploring the relationship between the structure of wheat dietary fibre and prebiotic activity." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/78863/.

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The relationships between wheat dietary fibre (DF) and prebiotic effects were investigated by testing how various DF types in different combinations and how the structure, of the major DF component of wheat, arabinoxylan (AX) modulate prebiotic activity. It was hypothesised that DFs could act synergistically resulting in different prebiotic activities when fermented in vitro at different ratios. The DF, arabinogalactan-peptide (AGP) was isolated from wheat flour and characterised, AX and mixed-linked β-glucan were commercially bought. The three fractions were tested singly and in combination i
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