Journal articles: 'Structure-based development'

1

Cui, Xin. "Structure design of knowledge base of software enterprise based on project development." Functional materials 24, no. 2 (June 22, 2017): 005–284. http://dx.doi.org/10.15407/fm24.02.278.

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Faig, Margarita, Mario A. Bianchet, Shannon Winski, Robert Hargreaves, Christopher J. Moody, Anna R. Hudnott, David Ross, and L. Mario Amzel. "Structure-Based Development of Anticancer Drugs." Structure 9, no. 8 (August 2001): 659–67. http://dx.doi.org/10.1016/s0969-2126(01)00636-0.

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Malito, Enrico. "Structure-based Vaccine Development (Structural Vaccinology)." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C697. http://dx.doi.org/10.1107/s2053273314093024.

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Structural biology is playing an increasingly important role in vaccine development, as it can facilitate the rational design of vaccines by allowing an atomic-level control of their antigenic and immunogenic properties. Several cases are now available that demonstrate the potential of structure-based methods for vaccine development. Here, I will present an overview of the insights we gained at Novartis Vaccines from studying two protein antigens of the recently approved vaccine against serogroup B meningococcus (MenB), and their impact for vaccine design and development. MenB causes severe sepsis and invasive meningococcal disease (IMD), particularly affecting young children and adolescents. In 2013, the first genome-derived vaccine, which targets MenB (4CMenB), was approved for use in Europe, and it is expected to become widely implemented in Europe beginning in 2014. The vaccine contains 3 previously unknown recombinant proteins discovered by genome mining. For one of the antigens, Factor H Binding Protein (FHBP), we recently generated a broadly protective chimera by a structure-based approach that consisted in grafting multiple immunodominant regions onto a single scaffold. Also, co-crystal structures of FHBP with Fabs from monoclonal antibodies provided insights into the molecular bases of the immune recognition and bactericidal activity. The structure of a second antigen, Neisserial adhesin A (NadA), a member of the Trimeric Autotransporter Adhesins (TAA), revealed a novel fold, while epitope mapping by Hydrogen-Deuterium Exchange Mass Spectrometry showed that in addition to being the receptor-binding domain, the head domain of NadA is also the target of a bactericidal monoclonal antibody. Overall, the structural information on the MenB antigens presented here provides important details on the pathogenesis and vaccine-induced immunity against meningococcus, and especially informs the engineering of improved immunogens by structure-based design.

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Martín-Gago, Pablo, Eyad Kalawy Fansa, Alfred Wittinghofer, and Herbert Waldmann. "Structure-based development of PDEδ inhibitors." Biological Chemistry 398, no. 5-6 (May 1, 2017): 535–45. http://dx.doi.org/10.1515/hsz-2016-0272.

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Abstract The prenyl binding protein PDEδ enhances the diffusion of farnesylated Ras proteins in the cytosol, ultimately affecting their correct localization and signaling. This has turned PDEδ into a promising target to prevent oncogenic KRas signaling. In this review we summarize and describe the structure-guided-development of the three different PDEδ inhibitor chemotypes that have been documented so far. We also compare both their potency for binding to the PDEδ pocket and their in vivo efficiency in suppressing oncogenic KRas signaling, as a result of the inhibition of the PDEδ/KRas interaction.

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Chen, Guo-fang, Ting-hai Xu, Yan Yan, Yu-ren Zhou, Yi Jiang, Karsten Melcher, and H. Eric Xu. "Amyloid beta: structure, biology and structure-based therapeutic development." Acta Pharmacologica Sinica 38, no. 9 (July 17, 2017): 1205–35. http://dx.doi.org/10.1038/aps.2017.28.

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Schlicker, Christine, Gina Boanca, Mahadevan Lakshminarasimhan, and Clemens Steegborn. "Structure-based development of novel sirtuin inhibitors." Aging 3, no. 9 (September 20, 2011): 852–72. http://dx.doi.org/10.18632/aging.100388.

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Saggaf, Said. "Policy impact of regional development based on local potential toward the economic structure of Bantaeng Regency." International Journal of Academic Research 6, no. 1 (January 30, 2014): 89–93. http://dx.doi.org/10.7813/2075-4124.2014/6-1/b.13.

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Zhang, Yingqun, Rui Song, Rob van Nes, Shiwei He, and Weichuan Yin. "Identifying Urban Structure Based on Transit-Oriented Development." Sustainability 11, no. 24 (December 17, 2019): 7241. http://dx.doi.org/10.3390/su11247241.

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The fast development of urbanization has led to imbalances in cities, causing congestion, pollution, and urban sprawl. In response to the growing concern over the distribution of demand and supply, a more coordinated urban structure is addressed in comprehensive planning processes. In this study, we attempt to identify urban structure using a Network–Activity–Human model under the Transit-Oriented Development (TOD) concept, since TOD is usually regarded as an urban spatial planning tool. In order to explore the strengths and weaknesses of the urban structure, we define the TOD index and unbalance degree and then classify the urban areas accordingly. We take the city of Beijing as a case study and identify nine urban types. The results show a hierarchical urban structure: the city center covers most of the hotspots which display higher imbalances, the surroundings of the city center are less developed, and the city edges show higher potentials in both exploitation and transportation development. Moreover, we discuss the extent to which the spatial scale influences the unbalance degree and apply a sensitivity analysis based on the goals of different stakeholders. This methodology could be utilized at any study scale and in any situation, and the results could offer suggestions for more accurate urban planning, strengthening the relationship between TOD and spatial organization.

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Tedeschi, L. O., R. R. White, C. F. Nicholson, B. L. Turner, M. A. Fonseca, and M. D. Hanigan. "1294 Traditional versus structure-based model development strategies." Journal of Animal Science 94, suppl_5 (October 1, 2016): 624. http://dx.doi.org/10.2527/jam2016-1294.

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Orry, Andrew J. W., Ruben A. Abagyan, and Claudio N. Cavasotto. "Structure-based development of target-specific compound libraries." Drug Discovery Today 11, no. 5-6 (March 2006): 261–66. http://dx.doi.org/10.1016/s1359-6446(05)03717-7.

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Schlicker, Christine, Annika Rauch, Ken C. Hess, Barbara Kachholz, Lonny R. Levin, Jochen Buck, and Clemens Steegborn. "Structure-Based Development of Novel Adenylyl Cyclase Inhibitors." Journal of Medicinal Chemistry 51, no. 15 (August 2008): 4456–64. http://dx.doi.org/10.1021/jm800481q.

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12

Peat, Malcolm. "Community based rehabilitation — development and structure: Part 1." Clinical Rehabilitation 5, no. 2 (May 1991): 161–66. http://dx.doi.org/10.1177/026921559100500211.

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Peat, Malcolm. "Community based rehabilitation — development and structure: Part 2." Clinical Rehabilitation 5, no. 3 (August 1991): 231–39. http://dx.doi.org/10.1177/026921559100500310.

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14

Kinoshita, Takayoshi. "Application and development of structure-based drug design using X-ray analysis." Folia Pharmacologica Japonica 129, no. 3 (2007): 186–90. http://dx.doi.org/10.1254/fpj.129.186.

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Zhang, Chongqian, Tingjun Hou, Zhiwei Feng, and Youyong Li. "Structure-Based Development of Antagonists for Chemokine Receptor CXCR4." Current Computer - Aided Drug Design 9, no. 1 (March 1, 2013): 60–75. http://dx.doi.org/10.2174/157340913804998739.

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Zhang, Chongqian, Tingjun Hou, Zhiwei Feng, and Youyong Li. "Structure-Based Development of Antagonists for Chemokine Receptor CXCR4." Current Computer Aided-Drug Design 9, no. 1 (January 27, 2013): 60–75. http://dx.doi.org/10.2174/1573409911309010006.

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17

GUO, Feng. "Logical iteration structure model based product development process simulation." Chinese Journal of Mechanical Engineering 43, no. 03 (2007): 72. http://dx.doi.org/10.3901/jme.2007.03.072.

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18

Ki, Won-yong, Seung-Jin Heo, Dae-Oh Kang, Hong Jae Yim, Kyung won Lee, Jung ho Kim, and Chang kun Lee. "Development of knowledge based body structure concept design model." International Journal of Automotive Technology 18, no. 3 (April 1, 2017): 429–37. http://dx.doi.org/10.1007/s12239-017-0043-3.

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19

Harris, R. A., and L. F. Cohn. "Development of Control Structure for Micro‐Based Expert System." Journal of Computing in Civil Engineering 5, no. 4 (October 1991): 412–27. http://dx.doi.org/10.1061/(asce)0887-3801(1991)5:4(412).

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20

Poppeova, V., J. Uricek, and Vl Bulej. "THE DEVELOPMENT OF MECHANISM BASED ON HYBRID KINEMATIC STRUCTURE." MM Science Journal 2011, no. 01 (March 16, 2011): 228–32. http://dx.doi.org/10.17973/mmsj.2011_03_201013.

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21

Maeda, Kenji, and Hiroaki Mitsuya. "Development of therapeutics for AIDS: Structure-based molecular targeting." Tuberculosis 87 (August 2007): S31—S34. http://dx.doi.org/10.1016/j.tube.2007.05.009.

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22

Yan, Zhiming, Ramana G. Reddy, Xuewei Lv, Zhengde Pang, and Wenchao He. "Structure-based viscosity model development for titania aluminosilicate slags." Ironmaking & Steelmaking 47, no. 2 (August 22, 2018): 203–9. http://dx.doi.org/10.1080/03019233.2018.1510876.

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23

Uliyah, Musrifatul, and Abdul Aziz Alimul Hidayat. "Objective Structure Clinical Examination (OSCE) Based Teaching Material Development." Advanced Science Letters 23, no. 12 (December 1, 2017): 12521–23. http://dx.doi.org/10.1166/asl.2017.10807.

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24

Barr, Valarie A., Eilon Sherman, Jason Yi, Itoro Akpan, Alexandre K. Rouquette-Jazdanian, and Lawrence E. Samelson. "Development of nanoscale structure in LAT-based signaling complexes." Journal of Cell Science 129, no. 24 (November 10, 2016): 4548–62. http://dx.doi.org/10.1242/jcs.194886.

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25

Yang, Z. Y., Y. G. Chen, and W. S. Sze. "Layer-based machining: Recent development and support structure design." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 216, no. 7 (July 1, 2002): 979–91. http://dx.doi.org/10.1243/09544050260174184.

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There is growing interest in additive and subtractive shaping theories that are synthesized to integrate the layered manufacturing process and material removal process. Recently, layer-based machining has emerged as a promising method for integrated additive and subtractive shaping theory. In this paper, major layer-based machining systems are reviewed and compared according to characteristics of stock layers, numerical control machining configurations, stacking operations, input format and raw materials. Support structure, a major issue in machining-based systems which has seldom been addressed in previous research, will be investigated in this paper with considerations of four situations: floating overhang, cantilever, vaulted overhang and ceiling. Except for the floating overhang where a support structure should not be overlooked, the necessity for support structures for the other three situations is determined by stress and deflection analysis. This will be demonstrated by the machining of a large castle model.

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Williams, W. V., D. A. Moss, T. Kieber-Emmons, J. A. Cohen, J. N. Myers, D. B. Weiner, and M. I. Greene. "Development of biologically active peptides based on antibody structure." Proceedings of the National Academy of Sciences 86, no. 14 (July 1, 1989): 5537–41. http://dx.doi.org/10.1073/pnas.86.14.5537.

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27

Darongke, Chyntia Christina, and Yusuf Latief. "Development of Safety Cost on Upper Structure Building Based on Work Breakdown Structure." Journal of Computational and Theoretical Nanoscience 17, no. 2 (February 1, 2020): 864–73. http://dx.doi.org/10.1166/jctn.2020.8733.

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Construction as one of the most influencing industry to the country’s economy on the other hand also have the highest number of workplace accidents. Based on the data, 32% of accidental cases in Indonesia happened on constructional sectors. Hazard combine with work environments, workers behavior, organizational factor are the few reasons on the high number of workplace accident. In order to controlling the accidents, the safety risks in the construction industry need to be addressed. This paper aims to developing the standardized work breakdown structure for upper structure in building as a series of task in the form activities and to identify the safety risks in construction project based on work breakdown structure in order to effectively listing the workplace safety risk to maximizing the prevention. The risks listed also following by the prevention needed for controlling the risks, and the prevention would help to develop the component needed for cost of safety. In the end, the component of the cost of safety based on the prevention on the risk for each work breakdown structure will be more detailed and accurate.

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28

Graham, Barney S., Morgan S. A. Gilman, and Jason S. McLellan. "Structure-Based Vaccine Antigen Design." Annual Review of Medicine 70, no. 1 (January 27, 2019): 91–104. http://dx.doi.org/10.1146/annurev-med-121217-094234.

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Enabled by new approaches for rapid identification and selection of human monoclonal antibodies, atomic-level structural information for viral surface proteins, and capacity for precision engineering of protein immunogens and self-assembling nanoparticles, a new era of antigen design and display options has evolved. While HIV-1 vaccine development has been a driving force behind these technologies and concepts, clinical proof-of-concept for structure-based vaccine design may first be achieved for respiratory syncytial virus (RSV), where conformation-dependent access to neutralization-sensitive epitopes on the fusion glycoprotein determines the capacity to induce potent neutralizing activity. Success with RSV has motivated structure-based stabilization of other class I viral fusion proteins for use as immunogens and demonstrated the importance of structural information for developing vaccines against other viral pathogens, particularly difficult targets that have resisted prior vaccine development efforts. Solving viral surface protein structures also supports rapid vaccine antigen design and application of platform manufacturing approaches for emerging pathogens.

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29

Lim, Sujin, and Kamyoung Kim. "Development of an Urban Sprawl Measure Based Density-spatial Structure." Journal of the Korean Cartographic Association 17, no. 1 (April 30, 2017): 87–101. http://dx.doi.org/10.16879/jkca.2017.17.1.087.

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30

Shirakura, K., T. Ishida, S. Nakamura, and K. Shimizu. "3P007 Development of profile-based potential for protein structure prediction." Seibutsu Butsuri 45, supplement (2005): S205. http://dx.doi.org/10.2142/biophys.45.s205_3.

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31

Brady, R., and Angus Cameron. "Structure-Based Approaches to the Development of Novel Anti-Malarials." Current Drug Targets 5, no. 2 (February 1, 2004): 137–49. http://dx.doi.org/10.2174/1389450043490587.

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32

O’Dowd, Colin R., Matthew D. Helm, J. S. Shane Rountree, Jakub T. Flasz, Elias Arkoudis, Hugues Miel, Peter R. Hewitt, et al. "Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors." ACS Medicinal Chemistry Letters 9, no. 3 (February 21, 2018): 238–43. http://dx.doi.org/10.1021/acsmedchemlett.7b00512.

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33

Xiong, Jijun, Zhaoying Zhou, Dong Sun, and Xiongying Ye. "Development of a MEMS based colloid thruster with sandwich structure." Sensors and Actuators A: Physical 117, no. 1 (January 2005): 168–72. http://dx.doi.org/10.1016/j.sna.2004.05.029.

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34

Ren, Yongchang, Deyi Jiang, Tao Xing, and Ping Zhu. "Research on software development platform based on SSH framework structure." Procedia Engineering 15 (2011): 3078–82. http://dx.doi.org/10.1016/j.proeng.2011.08.577.

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35

SUGIYAMA, Shuntaro, Yasuhiro SUGIMOTO, and Koichi OSUKA. "Development of walking robot based on the structure of locust." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2017 (2017): 1P1—D07. http://dx.doi.org/10.1299/jsmermd.2017.1p1-d07.

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36

Heine, A., J. Behnen, H. Köster, T. Craan, S. Brass, and G. Klebe. "Molecular probes as starting point for structure-based lead development." Acta Crystallographica Section A Foundations of Crystallography 67, a1 (August 22, 2011): C53. http://dx.doi.org/10.1107/s010876731109876x.

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37

Zhao, Li. "Resource-Based City Spatial Structure Evolution and Sustainable Development Research." Advanced Materials Research 962-965 (June 2014): 2521–24. http://dx.doi.org/10.4028/www.scientific.net/amr.962-965.2521.

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Resource-based cities in China are numerous, special urban formation mechanism and industrial structure make the resource-based cities to present unique urban spatial structure. Taking Pingdingshan (coal resource-based city) as an example, this article puts forward the corresponding spatial structure optimization strategy for the city's transformation and sustainable development by researching the city's spatial structure evolution, development characteristics and existing problems, and hopes to provide the experience of space structure adjustment and optimization for the similar resource-based cities, and then promotes the implementation of the resource-based cities' transformation and sustainable development in China.

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38

Tang, Dunbing, Ronghua Xu, Jicheng Tang, and Rui He. "Design structure matrix-based Engineering Change management for product development." International Journal of Internet Manufacturing and Services 1, no. 3 (2008): 231. http://dx.doi.org/10.1504/ijims.2008.021196.

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39

Schiedel, Matthias, Tobias Rumpf, Berin Karaman, Attila Lehotzky, Stefan Gerhardt, Judit Ovádi, Wolfgang Sippl, Oliver Einsle, and Manfred Jung. "Structure-Based Development of an Affinity Probe for Sirtuin 2." Angewandte Chemie International Edition 55, no. 6 (January 8, 2016): 2252–56. http://dx.doi.org/10.1002/anie.201509843.

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40

Cui, Qiang, Chia-Shih Cheng, Juin J. Liou, and Hsien-Chin Chiu. "Development of a New pHEMT-Based Electrostatic Discharge Protection Structure." IEEE Transactions on Electron Devices 58, no. 9 (September 2011): 2974–80. http://dx.doi.org/10.1109/ted.2011.2152843.

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41

Najjar, H., and H. Batis. "Development of Mn-based perovskite materials: Chemical structure and applications." Catalysis Reviews 58, no. 3 (July 2, 2016): 371–438. http://dx.doi.org/10.1080/01614940.2016.1198203.

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42

NOMURA, Kiyoe, Hiroto NARUSHIMA, Hideo YOKOTA, Ryutaro HIMENO, Hideki ARAKAWA, Kazuo TANISHITA, Satoshi TATESHIMA, and Fernando VINUERA. "Development of Cerebral Aneurysm Based on Realistic Model's Flow Structure." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2003.15 (2003): 377–78. http://dx.doi.org/10.1299/jsmebio.2003.15.377.

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43

Dandurand, Lawrence, and Neil A. Morgan. "A computer-based technology structure for international marketing strategy development." Journal of Strategic Marketing 1, no. 2 (June 1993): 141–52. http://dx.doi.org/10.1080/09652549300000009.

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44

Xu, Zhirong, Ping Yang, Yujia Zhang, Zhiji Zeng, Chengli Zheng, and Jiajun Peng. "Control devices development of multi-microgrids based on hierarchical structure." IET Generation, Transmission & Distribution 10, no. 16 (December 8, 2016): 4249–56. http://dx.doi.org/10.1049/iet-gtd.2016.0796.

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45

LinWu, Shiuan-Woei, Che-An Wu, Fu-Chuo Peng, and Andrew H. J. Wang. "Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis." Biochemical Pharmacology 83, no. 12 (June 2012): 1690–99. http://dx.doi.org/10.1016/j.bcp.2012.03.003.

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46

Zhang, Junwei, Masahiro Aizawa, Shinji Amari, Yoshio Iwasawa, Tatsuya Nakano, and Kotoko Nakata. "Development of KiBank, a database supporting structure-based drug design." Computational Biology and Chemistry 28, no. 5-6 (December 2004): 401–7. http://dx.doi.org/10.1016/j.compbiolchem.2004.09.003.

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47

Vlasak, P., M. Duskova-Smrckova, and K. Dusek. "Structure development in polyurethane networks based on star-like precursors." Journal of Coatings Technology and Research 4, no. 3 (July 21, 2007): 311–15. http://dx.doi.org/10.1007/s11998-007-9026-z.

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48

He, Wen, Lei Zhou, Miao Wang, Yang Cao, Xuemei Chen, and Xu Hou. "Structure development of carbon-based solar-driven water evaporation systems." Science Bulletin 66, no. 14 (July 2021): 1472–83. http://dx.doi.org/10.1016/j.scib.2021.02.014.

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Straková, Jarmila, Jan Váchal, Jaroslav Kollmann, and Milan Talíř. "Development trends in organizational and management structures." Problems and Perspectives in Management 19, no. 2 (July 6, 2021): 495–506. http://dx.doi.org/10.21511/ppm.19(2).2021.39.

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Development trends in management and organizational structures are considered one of the limitations of the ongoing transformation of the company architecture of enterprises in the Czech Republic. This study is based on the survey data of over 450 enterprises in different sizes and sector categories conducted in 2016–2019. Statistical dependence between the type of organizational structure and size of an enterprise is confirmed with a trend of transition to a department-based organizational structure at the expense of a division-based structure. A high degree of statistical dependence is found between the number of management levels and size of a company. However, a low level of statistical dependence is found between the number of management levels and the sector type. Dependence between management structure/size of an enterprise and its profitability is not confirmed. A critical strategic task for companies is acceleration of the transformation of the company architecture, including the organizational framework, and intensification of the innovation and digitalization based on a transfer of new knowledge into corporate practice. If enterprises accomplish this strategic task, they will generate higher value and they can be more profitable and sustainable. A transfer from classical management structures to departmental structures is demonstrated, which creates preconditions for transformation in process and project management. A new finding is an independent relationship between management structure/size of an enterprise and its profitability; and an opposite trend considering the number of management levels compared to the prediction, i.e., their decrease.

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Kouichirou, Anno, and Takeshi Nishihata. "DEVELOPMENT ON OFFSHORE STRUCTURE." Coastal Engineering Proceedings 1, no. 32 (January 31, 2011): 50. http://dx.doi.org/10.9753/icce.v32.structures.50.

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Authors have developed the offshore structure for control of sea environment named S-VHS construction method, which is composed of the sloping top slit-type caisson and steel pipe piles. The sloping top form enables to realize the remarkable reduction of wave force exerted on the dike body compared with the conventional one. In this paper, hydraulic feature with wave dissipation ability and wave force reduction effect are verified through some hydraulic experiments. After the preliminary study for the valid structure form, reflection and transmission ability for the selected structure models were tested with the hydraulic experiment relevant to the ratio of caisson width and wave length. Finally, wave force experiment was executed and it revealed the performance of wave force reduction. Based on the results, we proposed specific design wave force formula for S-VHS construction method.

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Journal articles on the topic 'Structure-based development'

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