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Journal articles on the topic 'Strychnine and Brucine Alkaloids'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Lv, Mingming, Meiyu Zhang, Yezhe Cheng, Kexia Zhang, Chenzhi Hou, and Xiaohui Chen. "Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8256278.

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Semen Strychni have been shown to have therapeutic effect in improving blood circulation, relieving rheumatic pain, and treating cancer. However, Semen Strychni could cause severe nephrotoxicity. The present study was designed to evaluate whether treatment with total glucosides from paeony (TGP) has renoprotective effect against nephrotoxicity induced by total alkaloids from Semen Strychni (TAS). The levels of blood urea nitrogen (BUN) and creatinine (Cr) were determined and histopathological changes were also examined to evaluate renal injury. Moreover, a HPLC-MS method was developed and vali

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2

Bhagwat D, Mali, Akuskar Deepak S., and Jivane Deepak M. "Separation and Detection of Nux Vomika Alkaloids by Thin-Layer Chromatography." Journal of Forensic Chemistry and Toxicology 3, no. 2 (2017): 95–97. http://dx.doi.org/10.21088/jfct.2454.9363.3217.4.

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Strychnine and brucine are the poisonous alkaloids, derived from seeds of strychnos nux vomica. These seeds are readily available in villages and often misused for poisoning. A systematic and complete detection and quantitation of different poisons including plant poison is carried out by forensic toxicologists. Their method involves screening of poisons and their instrumental assay. Although instrumental methods are sensitive, they are costly and involve elaborate instrumental assay. Therefore, a simple, rapid and cheap thinlayer chromatographic method for separation and detection of bioactiv

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3

Liu, Yun-Feng, Yong-Mei Guan, Shi-Yu Huang, Lu Wu, Wei-Feng Zhu, and Li-Hua Chen. "The Influence and Mechanism of Paeoniflorin and Albiflorin on Strychnine and Brucine Transport Through Madin-Darby Canine Kidney/Multidrug Resistance1 Cells In Vitro Model." Journal of Biobased Materials and Bioenergy 14, no. 5 (2020): 616–23. http://dx.doi.org/10.1166/jbmb.2020.1998.

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This research sought to study the influence and potentialmechanism of paeoniflorin and albiflorin on strychnine and brucine transport in MDCK-MDR1 cells regulated by P-gp. Cytotoxicity of drugs was tested by MTT assay, and the transport studies were performed in both directions in MDCK-MDR1 cells. The influence of drugs on P-gp ATPase, and the efflux function of P-gp, the expression levels of P-gp and MDR1 mRNA were also estimated. Strychnine and brucine showed well absorption, and the main transport mechanism might be passive diffusion. Verapamil could significantly decrease the efflux rate (

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4

Jain, Rajeev, Rohitashva Mani Tripathi, Archna Negi, and Shishir Pratap Singh. "A simple, cost-effective and rapid method for simultaneous determination of Strychnos nux-vomica alkaloids in blood and Ayurvedic medicines based on ultrasound-assisted dispersive liquid–liquid microextraction–thin-layer chromatography-image analysis." Journal of Chromatographic Science 58, no. 5 (2020): 477–84. http://dx.doi.org/10.1093/chromsci/bmaa007.

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Abstract A simple, rapid, cost-effective and green analytical method is developed based on ultrasound-assisted dispersive liquid–liquid microextraction (US-DLLME) coupled to thin-layer chromatography (TLC)-image analysis for the simultaneous determination of two major alkaloids of Strychnos nux-vomica L i.e., strychnine and brucine. The method is composed of three steps, namely (i) US-DLLME by injecting a mixture of 100-μL chloroform (extraction solvent) and 1-mL methanol (disperser solvent) in 5 mL of aqueous sample, followed by ultrasonication and centrifugation, (ii) TLC of 20 μL of sedimen

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5

Song, Xinli, Daobin Yang, Yunxia Wang, Wen Liu, Yonglin Wang, and Jiazhen Zhu. "Pharmacokinetic, acute toxicity, and pharmacodynamic studies of semen strychni total alkaloid microcapsules." Tropical Journal of Pharmaceutical Research 18, no. 9 (2021): 1985–92. http://dx.doi.org/10.4314/tjpr.v18i9.29.

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Purpose: To investigate the safety and effectiveness of semen strychni total alkaloid microcapsules (SSTAM), compared with semen strychni total alkaloids (SSTA). Methods: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to assess pharmacokinetics of brucine and strychnine in rats. Acute toxicity was investigated in pre-test and formal experiments in mice. The pharmacodynamics of SSTAM and SSTA were evaluated by their analgesic and anti-inflammatory activities. Results: With respect to brucine, the half-life of SSTA group (1.6 mg/kg), low-dose SSTAM group (6 mg

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6

Liu, Fei, Xiaolin Wang, Xu Han, Xiaoxin Tan, and Weijun Kang. "Cytotoxicity and DNA interaction of brucine and strychnine—Two alkaloids of semen strychni." International Journal of Biological Macromolecules 77 (June 2015): 92–98. http://dx.doi.org/10.1016/j.ijbiomac.2015.03.017.

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7

Mudhgi, Priya, Brijendra Singh Tomar, and Satbir Kumar Chawla. "Therapeutic Properties of Kuchala – A Short Review." International Research Journal of Ayurveda & Yoga 7, no. 7 (2024): 32–36. http://dx.doi.org/10.48165/irjay.2024.70706.

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Medicinal plants are a pool of organically active compounds. In texts, there are various allusions to the use of vishdraya as a medicine. Kuchala (Strychnos nux-vomica Linn), an evergreen tree, commonly known as poison nut is attributed with both poisonous and medicinal values. Alkaloids are the main bioactive ingredients in S. nux-vomica Linn, 80% of which are strychnine and brucine, as well as their derivatives such as brucine N-oxide or isostrychnine. In Ayurveda, it has been used for curing various ailments including paralysis, dyspepsia, itching, joint pain, dysentery, emotional disorders

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8

Bizek-Tatara, Renata. "Od lekarstwa do trucizny. O ambiwalencji roślin w powieści Hrabia Monte Christo Aleksandra Dumasa: kulczyba wronie oko i bób św. Ignacego." Medycyna Nowożytna 30, Suplement I (2024): 507–19. http://dx.doi.org/10.4467/12311960mn.24.030.20023.

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This article is devoted to the ambivalence of medicinal plants in the novel The Count of Monte Cristo by Alexandre Dumas, using the examples of the crow’s eye tree and the St. Ignatius bean. The author analyzes descriptions of the properties of alkaloids obtained from them – strychnine and brucine – which, when properly used, can be a disease-curing medicine and an effective lethal poison. She also discusses the sources from which the writer obtained medical and pharmaceutical knowledge about plant toxins, their action and the symptoms they cause.

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9

Hadden, Chad E., Brian D. Kaluzny, Russell H. Robins, and Gary E. Martin. "Effects ofN-oxidation on the15N chemical shifts in theStrychnos alkaloids strychnine and brucine." Magnetic Resonance in Chemistry 37, no. 4 (1999): 325–27. http://dx.doi.org/10.1002/(sici)1097-458x(199904)37:4<325::aid-mrc453>3.0.co;2-e.

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10

Khushali S. Shroff and Abhaychandra S. Inamdar. "An Atypical Case Report - Strychnos nux-vomica toxicity resulting from Vishtinduk Vati overdose linked with bradycardia." Journal of Ayurveda and Integrated Medical Sciences 9, no. 4 (2024): 270–74. http://dx.doi.org/10.21760/jaims.9.4.43.

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Strychnos nux-vomica, commonly known as poison nut, is a plant notorious for its toxic alkaloids, particularly strychnine and brucine. While cases of poisoning from nux-vomica ingestion have been documented, its occurrence following Vishtinduk Vati overdose is exceedingly rare. Here a case of a 55-year-old female with a known history of osteoarthritis who inadvertently overdosed on Vishtinduk Vati, an over-the-counter Ayurvedic medicine containing nux-vomica, in an attempt to alleviate her pain, led to severe poisoning characterized by classical symptoms of strychnine toxicity, including muscl

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11

Perumal B, Velmani S, Santhosh C, and Maruthupandian A. "Phytochemical and medicinal properties on Strychnos-nux-vomica (L)." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 1, no. 3 (2021): 96–99. http://dx.doi.org/10.46947/joaasr13201624.

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Strychnos nux-vomica L. (Loganiaceae) is a deciduous tree that grows in tropical areas and is distributed throughout India and Southeast Asia. The dried seed of this plant S. nux vomica has been applied clinically in Chinese medicine for hundreds of years. S. nuxvomica is a non edible tree with a strong content of two poisonous alkaloids, strychnine and brucine. S. nux-vomica which belongs to the family loganiaceaalso called Kanjiram is a medium-sized tree. Other names of S. nux-vomica are Kanjiram, Kuchla, Kupilu. Phytochemical analysis revealed the presence of alkaloid, carbohydrate, tannin,

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12

Smith, Graham, Urs D. Wermuth, Peter C. Healy, and Jonathan M. White. "Molecular Recognition in Proton-Transfer Compounds of Brucine with Achiral Substituted Salicylic Acid Analogues." Australian Journal of Chemistry 59, no. 5 (2006): 320. http://dx.doi.org/10.1071/ch06074.

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The 1:1 proton-transfer brucinium compounds from the reaction of the alkaloid brucine with 5-nitrosalicylic acid, 3,5-dinitrosalicylic acid, and 5-sulfosalicylic acid, namely anhydrous brucinium 5-nitrosalicylate (1), brucinium 3,5-dinitrosalicylate monohydrate (2), and brucinium 5-sulfosalicylate trihydrate (3) have been prepared and their crystal structures determined by X-ray crystallography. All structures further demonstrate the selectivity of brucine for meta-substituted benzoic acids and comprise three-dimensional hydrogen-bonded framework polymers. Two of the compounds (1 and 3) have t

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13

Farrington, H., F. Mendelsohn, S. Chan, L. Reinlib, and S. E. Guggino. "Strychnine-binding proteins in intestinal cells: novel brucine binding site with binding affinities for alkaloids." Journal of Pharmacology and Experimental Therapeutics 271, no. 2 (1994): 1074–79. https://doi.org/10.1016/s0022-3565(25)23787-9.

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14

Gao, Yan, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai, and Shuangcheng Ma. "A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide—A Comparative Study." Molecules 28, no. 3 (2023): 1341. http://dx.doi.org/10.3390/molecules28031341.

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Brucine (BRU) and brucine N-oxide (BNO) are prominent, bioactive, and toxic alkaloids in crude and processed Semen Strychni. Studies have demonstrated that BRU and BNO possess comprehensive pharmacological activities, such as anti-inflammatory and analgesic. In this context, a comparative study of BRU and BNO was performed by combination analysis of in silico ADMET prediction, in vivo toxicity evaluation, and potential action mechanism exploration. ADMET prediction showed that BRU and BNO might induce liver injury, and BRU may have a stronger hepatoxic effect. The prediction was experimentally

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15

Guo, Rixin, Ting Wang, Guohong Zhou, et al. "Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review." American Journal of Chinese Medicine 46, no. 01 (2018): 1–23. http://dx.doi.org/10.1142/s0192415x18500015.

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Strychnos nux-vomica L. belongs to the genus Strychnos of the family Loganiaceae and grows in Sri Lanka, India and Australia. The traditional medicinal component is its seed, called Nux vomica. This study provides a relevant and comprehensive review of S. nux-vomica L., including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology, thus providing a foundation for future studies. Up to the present day, over 84 compounds, including alkaloids, iridoid glycosides, flavonoid glycosides, triterpenoids, steroids and organic acids, among others, have been isolated and identified

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16

Braun, Doris E., and Ulrich J. Griesser. "Why Do Hydrates (Solvates) Form in Small Neutral Organic Molecules? Exploring the Crystal Form Landscapes of the Alkaloids Brucine and Strychnine." Crystal Growth & Design 16, no. 11 (2016): 6405–18. http://dx.doi.org/10.1021/acs.cgd.6b01078.

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17

Lin, Aihua, Xiaochun Su, Dan She, Kuncheng Qiu, Qianmei He, and Yiming Liu. "LC–MS/MS determination and comparative pharmacokinetics of strychnine, brucine and their metabolites in rat plasma after intragastric administration of each monomer and the total alkaloids from Semen Strychni." Journal of Chromatography B 1008 (January 2016): 65–73. http://dx.doi.org/10.1016/j.jchromb.2015.11.012.

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18

Diksha P. Nandurkar and Kalpana R. Chavhan. "A conceptual review on the efficacy of Agnitundi Vati in the management of Gridhrasi w.s.r. to Sciatica." Journal of Ayurveda and Integrated Medical Sciences 9, no. 2 (2024): 113–16. http://dx.doi.org/10.21760/jaims.9.2.17.

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Background: Gridhrasi is Shoolapradhan Nanatmaj Vata Vyadhi mainly caused due to vitiation of Vata Dosha. The cardinal signs and symptoms of Gridhrasi are Ruk, Toda, Muhuspandan, Stambha. Gridhrasi can be correlated with sciatica due to resemblance of symptoms. The prevalence of sciatica varies considerably ranging from 1.6% in the general population to 43% in selected working population. Sciatica is characterised by constant aching pain in the lumbar region radiating to the buttock, calf and foot caused by irritation to the sciatic nerve. Being a nervine disorder, it can be treated by a drug

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19

Guo, Liang, and Xiabing Qin. "Effect of Brucine on Three Chondrocyte Apoptosis Models." Tobacco Regulatory Science 7, no. 5 (2021): 1701–11. http://dx.doi.org/10.18001/trs.7.5.95.

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With the development of people’s application technology of Strychnine, Strychnine is a relatively common type of medicine in the current clinical treatment of arthritis patients. And in the actual treatment, because strychnine has an important effect on the apoptosis of three kinds of chondrocytes. Better results can often be achieved through the use of horse money, which is of great significance to patients. The analysis of the influence of strychnose on the apoptosis of the three types of chondrocytes has become the focus of research in the academic and industry circles. The purpose of this

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20

Oami, K. "Membrane potential responses of paramecium caudatum to bitter substances: existence of multiple pathways for bitter responses." Journal of Experimental Biology 201, no. 1 (1998): 13–20. http://dx.doi.org/10.1242/jeb.201.1.13.

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The membrane potential responses of Paramecium caudatum to the external application of bitter substances were examined by employing conventional electrophysiological techniques. Mutant cells defective in voltage-gated Ca2+ channels were used to record the potential responses in the absence of contamination by Ca2+ action potentials. The cells produced a transient depolarization followed by a transient hyperpolarization in response to a rapid whole-cell application of chloroquine, strychnine nitrate or brucine. Of these chemicals, chloroquine was the most potent. Cells produced a simple depolar

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21

Bialonska, B., and Z. Ciunik. "Strychnine and brucine self-assemblies: structures and properties." Acta Crystallographica Section A Foundations of Crystallography 61, a1 (2005): c284. http://dx.doi.org/10.1107/s010876730508791x.

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22

Zong, Yu-Ying, and Chun-tao Che. "Determination of Strychnine and Brucine by Capillary Zone Electrophoresis." Planta Medica 61, no. 05 (1995): 456–58. http://dx.doi.org/10.1055/s-2006-958136.

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23

BELICKY, L., and J. SOUCEK. "ChemInform Abstract: Determination of Strychnine and Brucine in Mixtures." ChemInform 25, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199402340.

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24

Coleman, William F. "Alkaloids: Strychnine, Codeine, Heroin, and Morphine." Journal of Chemical Education 81, no. 9 (2004): 1366. http://dx.doi.org/10.1021/ed081p1366.

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25

Yang, Guangming, Yang Pan, Liangjing Liu, and Yaping Jiang. "Simultaneous Determination of Strychnine, Brucine, Strychnine N-Oxide and Brucine N-Oxide in Crude and Fermented Nux Vomica by CZE with Ephedrine Hydrochloride as an Internal Standard." Chromatographia 73, no. 11-12 (2011): 1223–28. http://dx.doi.org/10.1007/s10337-011-1912-y.

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26

Ahmad, Sayeed, Kishwar Saleem, Abid Kamal, FJ Ahmad, and YT Kamal. "Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed." Journal of Pharmacy and Bioallied Sciences 4, no. 2 (2012): 134. http://dx.doi.org/10.4103/0975-7406.94814.

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27

Gharagozloo, Parviz, Sebastian Lazareno, Angela Popham, and Nigel J. M. Birdsall. "Allosteric Interactions of Quaternary Strychnine and Brucine Derivatives with Muscarinic Acetylcholine Receptors." Journal of Medicinal Chemistry 42, no. 3 (1999): 438–45. http://dx.doi.org/10.1021/jm970799y.

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28

Chan, T. Y. K. "Herbal medicine causing likely strychnine poisoning." Human & Experimental Toxicology 21, no. 8 (2002): 467–68. http://dx.doi.org/10.1191/0960327102ht259cr.

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`Maqianzi’ (the dried ripe seed of Strychnos nux-vomica L.) contains 1.0–1.4% each of strychnine and brucine. After processing to reduce its toxicity, `maqianzi’ was used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis. A 42-year old woman with neck pain was prescribed 15 g of `maqianzi’ to be taken in two doses at 7 hours apart, although the recommended dose was 0.3–0.6 g. She was apparently well after drinking the first of two bowls of `maqianzi’ decoction. One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions o

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29

Bandopadhyay, J., and B. De. "SEASONAL VARIATION OF STRYCHNINE AND BRUCINE IN VEGETATIVE PARTS OF STRYCHNOS NUX-VOMICA." International Journal of Pharmacognosy 35, no. 5 (1997): 349–53. http://dx.doi.org/10.1080/09251619708951281.

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30

Mishra, Swati Dubey, Devasish Bose, S. K. Shukla, Abhilasha Durgabanshi, and J. Esteve-Romero. "Monitoring strychnine and brucine in biochemical samples using direct injection micellar liquid chromatography." Analytical Methods 5, no. 7 (2013): 1747. http://dx.doi.org/10.1039/c3ay26014c.

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31

Glover, S. S. B., R. O. Gould, and M. D. Walkinshaw. "Structures of strychnine (I), C21H22N2O2, and a solvate of brucine (II), C23H26N2O4.C2H6O.2H2O." Acta Crystallographica Section C Crystal Structure Communications 41, no. 6 (1985): 990–94. http://dx.doi.org/10.1107/s0108270185006308.

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32

Gu, Xuexin, Hongxia Li, Ruohua Zhu, and Hong Zou. "Determination of Strychnine and Brucine in Strychnos nux-vomica L. by Nonaqueous Capillary Electrophoresis." Chromatographia 63, no. 5-6 (2006): 289–92. http://dx.doi.org/10.1365/s10337-006-0734-9.

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33

Jensen, Anders A., Parviz Gharagozloo, Nigel J. M. Birdsall та Darius P. Zlotos. "Pharmacological characterisation of strychnine and brucine analogues at glycine and α7 nicotinic acetylcholine receptors". European Journal of Pharmacology 539, № 1-2 (2006): 27–33. http://dx.doi.org/10.1016/j.ejphar.2006.04.010.

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34

Białońska, Agata, and Zbigniew Ciunik. "Racemic resolution of N-protected alanine by strychnine and brucine versus donor/acceptor capability." CrystEngComm 6, no. 47 (2004): 276–79. http://dx.doi.org/10.1039/b407210c.

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35

Ghazi, M., and D. P. Matthees. "Opposing effects of strychnine and brucine on the germination and growth of lettuce seeds." Journal of Plant Growth Regulation 9, no. 1-4 (1990): 95–96. http://dx.doi.org/10.1007/bf02041948.

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36

Kirubakarababu, Merlin, and Arputharaj Samson Nesaraj. "Transition of Therapeutic to Toxicological Effects of Certain Plant Alkaloids: A Critical Review Based on their Forensic Perspective." Asian Journal of Chemistry 34, no. 7 (2022): 1613–24. http://dx.doi.org/10.14233/ajchem.2022.23604.

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The secondary metabolites have a significant property of therapy as well as toxicity. One among the secondary metabolite that is enormously present in plants is alkaloids. The occurrence of the alkaloid is found to be about 20% in the plants. These compounds have a useful therapeutic application in health disorders. On the other hand, they also cause toxicity to humans as well as animals. Their toxicity levels in humans may tend to affect the gastrointestinal and nervous systems. In this review, occurrence, synthesis and the toxicity levels of non-heterocyclic alkaloids viz. N-methyl tyramine

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37

Smith, Graham, Urs D. Wermuth, Peter C. Healy, and David J. Young. "Strychnine-8-ammonio-2-naphthalenesulfonate-water (1/1/3.5): The first structure of a strychnine or brucine compound with a zwitterionic species." Journal of Chemical Crystallography 36, no. 12 (2006): 805–11. http://dx.doi.org/10.1007/s10870-006-9085-5.

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38

Rathi, Anshu, Neena Srivastava, Sayyada Khatoon, and Ajay K. S. Rawat. "TLC Determination of Strychnine and Brucine of Strychnos nux vomica in Ayurveda and Homeopathy Drugs." Chromatographia 67, no. 7-8 (2008): 607–13. http://dx.doi.org/10.1365/s10337-008-0556-z.

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39

Xu, Yanyan, Duanyun Si, and Changxiao Liu. "Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry." Journal of Pharmaceutical and Biomedical Analysis 49, no. 2 (2009): 487–91. http://dx.doi.org/10.1016/j.jpba.2008.10.020.

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40

Zhang, Jiyou, Shufang Wang, Xingguo Chen, Zhide Hu, and Xiao Ma. "Capillary electrophoresis with field-enhanced stacking for rapid and sensitive determination of strychnine and brucine." Analytical and Bioanalytical Chemistry 376, no. 2 (2003): 210–13. http://dx.doi.org/10.1007/s00216-003-1852-y.

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41

Krivdin, Leonid, and Valentin Semenov. "HIGH-PRECISION CALCULATION OF 1H AND 13C NMR CHEMICAL SHIFTS OF STRICHNINA ALKALOIDS." Modern Technologies and Scientific and Technological Progress 1, no. 1 (2021): 40–42. http://dx.doi.org/10.36629/2686-9896-2021-1-1-40-42.

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The calculation of 1H and 13C NMR chemical shifts in the series of strychnine  alkaloids using the Purdue-Burke-Ernzerhof functional, PBE0, with segmented Jensen basis sets of  threefold splitting level pcSseg-2 and pcseg-2, PBE0 / pcSg-2 // pcseg-2.

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42

Guo, Jun, Hua Meng, Huang Huang Li, and Qiao Feng Wang. "Determination of strychnine, brucine, strychnine N-oxide, and brucine N-oxide in plasma samples after the oral administration of processed semen strychni extract by high-performance liquid chromatography with ultrasound-assisted mixed cloud point extracti." Journal of Separation Science 39, no. 13 (2016): 2553–61. http://dx.doi.org/10.1002/jssc.201501379.

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43

Hauser, Marie-Theres, and Michael Wink. "Uptake of Alkaloids by Latex Vesicles and Isolated Mesophyll Vacuoles of Chelidonium ntajus (Papaveraceae)." Zeitschrift für Naturforschung C 45, no. 9-10 (1990): 949–57. http://dx.doi.org/10.1515/znc-1990-9-1005.

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Abstract Latex vacuoles of Chelidonium majus (Papaveraceae) naturally sequester protoberberine and benzophenanthridine alkaloids. Isolated vesicles take up a number of other heterologous alkaloids, such as 9,10-dihydroergocryptine, vinblastine, strychnine, nicotine, colchicine, lupanine, and 13-hydroxylupanine, with a strong preference for the indole alkaloids and for nicotine. Kinetic data clearly show that the uptake proceeds via simple diffusion and not by carrier-mediated transport. The alkaloids are concentrated in the vesicles against a concentra tion gradient. MgATP has no influence on

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44

Yang, Xiumin, Shuaihua Zhang, Juntao Wang, Chun Wang, and Zhi Wang. "On-line two-step stacking in capillary zone electrophoresis for the preconcentration of strychnine and brucine." Analytica Chimica Acta 814 (March 2014): 63–68. http://dx.doi.org/10.1016/j.aca.2014.01.027.

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45

Hoogenboom, Jacobus J. L., and Colin G. Rammell. "Liquid Chromatographic Determination of Strychnine in Stomach Contents." Journal of AOAC INTERNATIONAL 68, no. 6 (1985): 1131–33. http://dx.doi.org/10.1093/jaoac/68.6.1131.

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Abstract A chloroform extract of stomach contents at basic pH is concentrated and then extracted with 0.1M phosphoric acid. The acid extract is chromatographed on a 10 cm reverse phase column, using 0.005M phosphate buffer (pH 3.0)-acetonitrile-tetrahydrofuran (750 + 135 + 115) containing 0.01M octanesulfonic acid at a flow rate of 1.0 raL/ min for elution. Strychnine eluted in 7.3 min. Recoveries from spiked stomach contents averaged 92%. The method can be used without modification for other alkaloids.

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Li, Jinying, Shi Hu, Pei Feng, et al. "Brucine Sulfate, a Novel Bacteriostatic Agent in 3D Printed Bone Scaffold Systems." Polymers 16, no. 10 (2024): 1428. http://dx.doi.org/10.3390/polym16101428.

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Bacterial infection is a common complication in bone defect surgery, in which infection by clinically resistant bacteria has been a challenge for the medical community. Given this emerging problem, the discovery of novel natural-type inhibitors of drug-resistant bacteria has become imperative. Brucine, present in the traditional Chinese herb Strychnine semen, is reported to exert analgesic and anti-inflammatory effects. Brucine’s clinical application was limited because of its water solubility. We extracted high-purity BS by employing reflux extraction and crystallization, greatly improved its

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Abbas, Khamis A., Phillip Hurst, and John T. Edward. "Reexamination of the Kirkwood–Westheimer theory of electrostatic effects. V. Effect of charged substituents on the rates of alkaline hydrolysis of substituted strychnines." Canadian Journal of Chemistry 75, no. 4 (1997): 441–48. http://dx.doi.org/10.1139/v97-050.

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The rates of hydrolysis in aqueous sodium hydroxide of the alkaloid strychnine and seven of its derivatives have been determined at 50 and 75 °C. The kinetic data indicate that all the compounds, except strychninesulfoni acid-I, hydrolyze by competing second- and third-order mechanisms, involving one and two hydroxide ions, respectively; strychninesulfonic acid-I hydrolyzes by the second-order mechanism only. The quantitative effect of positively charged groups in enhancing, and negatively charged groups in depressing, the rates of hydrolysis is in rough agreement with calculations using Kirkw

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CHEN, Jun, Ting HOU, Yun FANG, et al. "HPLC Determination of Strychnine and Brucine in Rat Tissues and the Distribution Study of Processed Semen Strychni." YAKUGAKU ZASSHI 131, no. 5 (2011): 721–29. http://dx.doi.org/10.1248/yakushi.131.721.

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Wang, Z., J. Zhao, J. Xing, Y. He, and D. Guo. "Analysis of Strychnine and Brucine in Postmortem Specimens by RP-HPLC: A Case Report of Fatal Intoxication." Journal of Analytical Toxicology 28, no. 2 (2004): 141–44. http://dx.doi.org/10.1093/jat/28.2.141.

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Song, Xin-Yue, Yan-Ping Shi, and Juan Chen. "Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine." Talanta 116 (November 2013): 188–94. http://dx.doi.org/10.1016/j.talanta.2013.05.025.

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