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1

Gohlke, Holger, ed. Protein-Ligand Interactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527645947.

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2

Williams, Mark A., and Tina Daviter, eds. Protein-Ligand Interactions. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-398-5.

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3

Nienhaus, G. Ulrich. Protein-Ligand Interactions. Humana Press, 2005. http://dx.doi.org/10.1385/1592599125.

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4

Daviter, Tina, Christopher M. Johnson, Stephen H. McLaughlin, and Mark A. Williams, eds. Protein-Ligand Interactions. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1197-5.

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5

Protein-ligand interactions: Methods and applications. 2nd ed. Humana Press, 2013.

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6

Press, Humana, ed. Protein-ligand interactions: Methods and applications. Humana Press, 2010.

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7

Ballante, Flavio, ed. Protein-Ligand Interactions and Drug Design. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1209-5.

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8

Ismail, Matthew Arif. DNA-ligand interactions: A biophysical study of 9-hydroxyellipticine, Hoechst 33258 and a meso-substituted porphyrin derivative binding to DNA. typescript, 1998.

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9

Wang, Jianpeng. Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface Modification. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-53399-4.

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10

Martin, R. P. Synthesis of a thiosugar analogue of an N - linked oligosaccharide fragment: A tool for the study of carbohydrate -protein interactions. UMIST, 1995.

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11

NATO ASI/FEBS Course on DNA-Ligand Interactions: From Drugs to Proteins (1986 Abbey of Fontevraud). DNA-ligand interactions: From drugs to proteins. Plenum Press, 1987.

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12

Rahman, Masoud. Protein-Nanoparticle Interactions: The Bio-Nano Interface. Springer Berlin Heidelberg, 2013.

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13

Tax, Frans. Receptor-like Kinases in Plants: From Development to Defense. Springer Berlin Heidelberg, 2012.

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14

Wallis, Russell. A study of the interaction between Colicin E9 and its immunity protein. University of East Anglia, 1992.

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15

Robert, Rein, and Golombek Amram, eds. Computer-assisted modeling of receptor-ligand interactions: Theoretical aspects and applications to drug design : proceedings of the 1988 OHOLO Conference held in Eilat, Israel, April 24-28, 1988. Liss, 1989.

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16

Hernandez, Marta. The study of ligand binding specificities of the lipid binding proteins: Recombinant human a-tocopherol transport protein (a-ttp), supernatant protein factor (spf) and S. cerevisiae Sec 14p for vitamin e (rrr-a-tocopherol) and other hydrophobic ligands. Brock University, Dept. of Biotechnology, 2003.

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17

NATO, Advanced Study Institute on Structure and Function of Interacting Protein Domains in Signal and Energy Transduction (1996 Acquafredda di Maratea Italy). Interacting protein domains: Their role in signal and energy transduction : [proceedings of the NATO Advanced Study Institute on Structure and Function of Interacting Protein Domains in Signal and Energy Transduction, held at Acquafredda di Maratea, Italy, September 10-19, 1996]. Springer, 1997.

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18

Brown, Marc Barry. The use of long wavelength fluorescence in the study of ligand-protein interactions. 1993.

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19

Protein Interactions: Biophysical Approaches for the Study of Complex Reversible Systems (Protein Reviews). Springer, 2007.

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20

Ma, Haijun. Single molecule force spectroscopy of membrane receptor-ligand interactions: A model study. 2005.

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21

Vrecl, Milka, ed. The use of BRET to study receptor-protein interactions. Frontiers Media SA, 2014. http://dx.doi.org/10.3389/978-2-88919-223-6.

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22

Folkers, Gerd, Raimund Mannhold, Hugo Kubinyi, and Holger Gohlke. Protein-Ligand Interactions. Wiley & Sons, Limited, John, 2012.

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23

Folkers, Gerd, Raimund Mannhold, Hugo Kubinyi, and Holger Gohlke. Protein-Ligand Interactions. Wiley & Sons, Incorporated, John, 2012.

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24

Folkers, Gerd, Raimund Mannhold, Hugo Kubinyi, and Holger Gohlke. Protein-Ligand Interactions. Wiley & Sons, Incorporated, John, 2012.

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25

Böhm, H. ‐J, and G. Schneider, eds. Protein‐Ligand Interactions. Wiley, 2003. http://dx.doi.org/10.1002/3527601813.

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26

Folkers, Gerd, Raimund Mannhold, Hugo Kubinyi, and Holger Gohlke. Protein-Ligand Interactions. Wiley & Sons, Incorporated, John, 2012.

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27

Betel, Doron. A computational study of the role of conserved domains in protein interactions. 2005.

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28

Ulrich, Nienhaus G., ed. Protein-ligand interactions: Methods and applications. Humana Press, 2005.

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29

DNA-ligand interactions. Plenum published in cooperation with NATO Scientific Affairs Division, 1987.

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30

Wang, Jianpeng. Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface Modification. Springer, 2016.

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31

Wang, Jianpeng. Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface Modification. Springer, 2018.

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32

Schneider, Gisbert, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Hans-Joachim B�hm. Protein-Ligand Interactions: From Molecular Recognition to Drug Design. Wiley & Sons, Incorporated, John, 2006.

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33

Z, Chowdhry Babur, and Harding S. E, eds. Protein-ligand interactions : hydrodynamics and calorimetry: A practical approach. Oxford University Press, 2001.

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34

E, Harding S., and Chowdhry Babur Z, eds. Protein-ligand interactions, structure and spectroscopy: A practical approach. Oxford University Press, 2001.

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35

Hans-Joachim, Böhm, and Schneider Gisbert 1965-, eds. Protein-ligand interactions from molecular recognition to drug design. Wiley-VCH, 2003.

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36

Schneider, Gisbert, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Hans-Joachim B�hm. Protein-Ligand Interactions: From Molecular Recognition to Drug Design. Wiley & Sons, Limited, John, 2005.

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37

Robert, Stroud, and Finer-Moore Janet, eds. Computational and structural approaches to drug discovery: Ligand-protein interactions. RSC Publishing, 2008.

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38

Laurent, Sophie, L'Hocine Yahia, Masoud Rahman, Morteza Mahmoudi, and Nancy Tawil. Protein-Nanoparticle Interactions: The Bio-Nano Interface. Springer, 2015.

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39

Laurent, Sophie, Masoud Rahman, and Nancy Tawil. Protein-Nanoparticle Interactions: The Bio-Nano Interface. Springer, 2013.

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40

Kubinyi, Hugo. 3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity. Springer, 2010.

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41

(Editor), Stephen E. Harding, and Babur Z. Chowdhry (Editor), eds. Protein-Ligand Interactions: A Practical Approach 2 Volume-Set (Practical Approach). Oxford University Press, USA, 2001.

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42

Proteinligand Interactions. Wiley-VCH Verlag GmbH, 2012.

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43

DNA-Ligand Interactions:From Drugs to Proteins. Springer, 1987.

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44

(Editor), Stephen E. Harding, and Babur Z. Chowdhry (Editor), eds. Protein-Ligand Interactions: A Practical Approach Volume 1: Hydrodynamics and Calorimetry (Practical Approach Series). Oxford University Press, USA, 2001.

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45

(Editor), Stephen E. Harding, and Babur Z. Chowdhry (Editor), eds. Protein-Ligand Interactions: A Practical Approach Volume 2: Structure and Spectroscopy (Practical Approach Series). Oxford University Press, USA, 2001.

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46

(Editor), S. E. Harding, and Babur Chowdhry (Editor), eds. Protein-Ligand Interactions: A Practical Approach Volume 1: Hydrodynamics and Calorimetry (Practical Approach Series). Oxford University Press, USA, 2001.

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47

Sund, Horst, and Gideon Blauer. Protein-Ligand Interactions: Proceedings of the Symposium Held at the University of Konstanz, Germany, September 1974. De Gruyter, Inc., 2019.

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48

Nucleic Acid Structure and Recognition. Oxford University Press, USA, 2002.

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49

Protein–Ligand Interactions: Deciphering the Molecular Targets and the Mechanisms of Action of Drugs and Natural Compounds. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-0365-1051-4.

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50

Sherwood, Dennis, and Paul Dalby. Macromolecular conformations and interactions. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198782957.003.0025.

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Abstract:
As a polymer of many amino acids, any given protein can, in principle, adopt a huge number of configurations. In reality, however, the biologically stable protein adopts a single configuration that is stable over time. Thermodynamically, this configuration must represent a Gibbs free energy minimum. This chapter therefore explores how the thermodynamics and kinetics of protein folding and unfolding can be investigated experimentally (using, for example, chaotropes, heating or ligand interactions), and how these measurements can be used to enrich our understanding of protein configurations and
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