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Dissertations / Theses on the topic 'Study of structure-activity relationships'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Gooch, Carolyn A. "Quantitative structure-activity relationships : a biophysical, chemical and calorimetric study." Thesis, Royal Holloway, University of London, 1988. http://repository.royalholloway.ac.uk/items/26719d55-b208-4995-bef0-92e4f0f80c0e/1/.

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Quantitative structure-activity relationships (QSAR) rationalize interrelation between molecular structure and biological response in terms of either physicochemical parameters, as in linear free energy relationships (LFER), or via purely empirical parameters, as is the case for De Novo schemes. In LFER the leading process is often the partitioning of a compound between two solvent phases, taken to represent the transfer of a drug molecule across a biological membrane. This study has investigated the partitioning behaviour of three series of hydroxybenzoate esters, viz. o-, m- and predominantl

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2

Tomita, Kenji. "Structure-activity Relationship Study on GPR54 Agonists." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124039.

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3

Bender, Shana Lynn. "A study of protein dynamics and cofactor interactions in Photosystem I." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26463.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Barry, Bridette; Committee Member: Doyle, Donald; Committee Member: Kelly, Wendy; Committee Member: McCarty, Nael; Committee Member: Schimdt-Krey, Ingaborg. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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4

Pandit, Bulbul. "Study of structure activity relationship of analogs derived from SU-5416 and thalidomide and mechanism of antiproliferative activity." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187127289.

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5

Biwi, James Tapiwa. "A Structure-Activity Relationship Study of Dihydroajoenes as Anti-Cancer Agents." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12826.

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Includes bibliographical references.<br>Ajoene (( E-/Z )-4,5,9-trithiadodeca-1,6,11-triene-9-oxide), a constituent of garlic is known to possess in vitro and in vivo anticancer activity based on the presence of a vinyl disulfide as its pharmacophore. This thesis reports on the synthesis of dihydroajoenes, a novel set of ajoene analogues, containing a saturated double bond, in which the intention was to study the influence of removing the double bond on biological activity and metabolic stability, since ajoenes are unstable in blood. A divergent synthetic route to 6 new dihydroajoene analogues

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6

Selvadurai, Jayashankar [Verfasser]. "A combinatorial approach to study structure-activity relationships of myosins and dynamins using small molecule modulators / Jayashankar Selvadurai." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2012. http://d-nb.info/1024918939/34.

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7

Smith, Mark David. "A quantitative structure-activity relationship (QSAR) study of the Ames mutagenicity assay." Thesis, University of Portsmouth, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343333.

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In-vitro mutagenicity assays have traditionally been used for first line identification of potential genotoxic hazard, purporting to chemical carcinogenesis and heritable genetic damage. The recent advances m combinatorial chemistry and high throughput screening technologies have led to a massive explosion in numbers of possible therapeutic candidates being produced at the early stages of drug discovery. This rapid increase in the number of chemicals to be classified results in a greater need for to acquire alternative methods for the prediction of toxicity. Quantitative StructureActivity Rela

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8

Steffen, Jamin D. "Design, Development, and Evaluation of Tools to Study Cellular ADP-ribose Polymer Metabolism." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202973.

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The metabolism of ADP-ribose polymers (PAR) is involved in several cellular processes with a primary focus on maintaining genomic integrity. PAR metabolism following genotoxic stress is transient due to a close coordination between poly(ADP-ribose) polymerases (PARPs) which synthesize PAR and poly(ADP-ribose) glycohydrolase (PARG) which degrades PAR. PARP-1 inhibitors have emerged as promising anticancer therapeutics by increasing chemotherapy sensitivity and selectively target tumors harboring DNA repair defects. Several pharmaceutical companies have PARP-1 inhibitors in clinical trials for t

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9

Lee, Chen-Jung. "Study of Structure-Function Relationships of Zwitterionic Polymers." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522791050772284.

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10

Diaz-Perez, Maria-Jose. "Quantitative structure-activity relationship (QSAR) study of the effect of steroids on DNA replication." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ50291.pdf.

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11

Rosales, Rolando Barahona. "Condensed tannins in tropical forage legumes : their characterisation and study of their nutritional impact from the standpoint of structure-activity relationships." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298970.

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12

Dai, Yumin. "Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/24193.

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The Kingston group's engagement in an International Cooperative Biodiversity Group (ICBG) program and a collaborative research project established between Virginia Tech and the Institute for Hepatitis and Virus Research (IHVR) has focused on the search for bioactive natural products from tropical forests in both Madagascar and South Africa. As a part of this research, a total of four antiproliferative extracts were studied, leading to the isolation of fourteen novel compounds with antiproliferative activity against the A2780 human ovarian cancer line. One extract with antimalarial activity was

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13

Shrestha, Jaya P. "Synthesis, Structure-Activity Relationship Study, and Mode of Action Study of 1,4-Naphthoquinone Based Anticancer and Antimicrobial Agents." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4925.

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Synthesizing bioactive small molecules by structural modification of 1,4-naphthoquinone was the primary goal of this research. Several bioactive compounds with anticancer, antifungal, and antibacterial activities were synthesized. All the synthetic protocols were optimized in such ways that do not require cumbersome purification. First, a new protocol for the synthesis of NQM111 was developed. NQM111 is a highly potent anticancer agent developed in our laboratory, but the old protocol does not provide enough quantity for in vivo study. Therefore, a new safe and improved method was developed wh

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14

Cakkol, Mehmet. "How does servitization impact inter-organisational structure and relationships of a truck manufacturer's network?" Thesis, Cranfield University, 2013. http://dspace.lib.cranfield.ac.uk/handle/1826/8285.

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© Cranfield University 2013. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright owner.<br>Network relationships play a significant role in the provision of servitized offerings. To date, little empirical research has been conducted to investigate the link between servitization and inter-organisational relationships. The objective of this doctoral thesis is to explore the implications of servitization on a manufacturer’s network. Particular emphasis is placed on the impact on the network structure and relationship attributes. An

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15

Hyatt, Neil. "A study of structure-property relationships in layered copper oxides." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368293.

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16

Hotze, Anna Catharina Genovefa. "Design of ruthenium anticancer drugs : study of the structure-activity relationships and binding to DNA model bases of ruthenium complexes with 2-phenylazopyridine ligands /." Rotterdam : Optima Grafische Communicatie, 2003. http://catalogue.bnf.fr/ark:/12148/cb399315937.

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17

Matheson, I. L. "A study of structure-property relationships in certain polymeric dental materials." Thesis, University of Abertay Dundee, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379850.

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Acrylic resin artificial teeth may be produced by Transfer or Pseudo compression moulding. Both of these moulding techniques were investigated to formulate the best conditions for use in a mass production environment and evaluated on a commercial basis. It was found that the transfer technique, despite higher material costs, was the most commercially viable. The effects of seven process variables on the mechanical properties of polymer systems produced by the transfer method were evaluated by comparing their stiffness, strength, viscoelastic behaviour, and hardness. The variables studied were:

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18

Wang, Shaomeng. "Quantitative structure activity relationship study of anti-Mycobacterium avium agents and the calculation of some physico-chemical properties of organic compounds." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1056656561.

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19

Xing, Li. "Non-enveloped virus infection probed with host cellular molecules : a structural study /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-289-2.

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20

Duplock, Elizabeth. "First principles study of structure-property relationships in nano-structured carbon materials." Thesis, University of Kent, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429796.

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21

Smith, Geoffrey P. "A study of the structure-function relationships of Bacillus thuringiensis #delta#-endotoxins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260464.

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22

Rettew, Robert E. "Near-surface study of structure-property relationships in electrochemically fabricated multi-component catalysts." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45841.

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This work outlines a series of developments and discoveries related to surface chemistry of controlled near-surface architectures. Through a combination of various X-ray spectroscopy techniques and innovative electrochemical fabrication techniques, valuable knowledge has been added to the fields of electrochemical fabrication, electrocatalysis, and fundamental surface chemistry. Described here is a specific new development in the technique of surface limited redox replacement (SLRR). This work, along with an accompanying journal publication1, reports the first-ever use of nickel as an intermed

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23

Greenhagen, Bryan T. "ORIGINS OF ISOPRENOID DIVERSITY: A STUDY OF STRUCTURE-FUNCTION RELATIONSHIPS IN SESQUITERPENE SYNTHASES." UKnowledge, 2003. http://uknowledge.uky.edu/gradschool_diss/440.

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Plant sesquiterpene synthases catalyze the conversion of the linear substrate farnesyl diphosphate, FPP, into a remarkable array of secondary metabolites. These secondary metabolites in turn mediate a number of important interactions between plants and their environment, such as plant-plant, plant-insect and plant-pathogen interactions. Given the relative biological importance of sesquiterpenes and their use in numerous practical applications, the current thesis was directed towards developing a better understanding of the mechanisms employed by sesquiterpene synthases in the biosynthesis of s

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24

Meng, Guangtao, and 孟廣濤. "Study of structure-function relationships in globulin from Phaseolus angularis (red bean) seeds." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31242170.

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25

Mitchell, Michael John. "The molecular basis of factor XI deficiency : a study of structure/function relationships." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440457.

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26

Meng, Guangtao. "Study of structure-function relationships in globulin from Phaseolus angularis (red bean) seeds." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2282392X.

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27

Greenhagen, Bryan T. "Origins of isoprenoid diversity a study of structure-function relationships in sesquiterpene systems /." Lexington, Ky. : [University of Kentucky Libraries], 2003. http://lib.uky.edu/ETD/ukyplph2003d00093/Greenhagen.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2003.<br>Title from document title page (viewed onJune 1, 2004). Document formatted into pages; contains x, 145 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 126-143).

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28

Hettinger, Barbara J. (Barbara Jane). "Grandparent Satisfaction and Family Structure: a Descriptive Study of Multigenerational Families in Denton County, Texas." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc332273/.

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This descriptive study of 45 multi-generational families contributes empirical knowledge about grandparent-grandchild relationships. A questionnaire was developed and completed by 74 subjects who were part of a randomly selected sample taken from a tax roll of homeowners over age 65 in Denton County, Texas. The responses provide information which expands the existing data base in the area of grandparenting. The study pinpoints areas in the grandparenting literature which need refinement and contributes data to those areas, rather than producing a set of conclusions. Areas as yet undocumented

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29

Mortamet, Anne-Cecile. "Study of the structure-property relationships in polyurethane elastomers derived from a biosourced polyol." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544025.

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30

Choi, Siu-mei, and 蔡少薇. "Study of structure-function relationships in globulin from common buckwheat (Fagopyrum esculentum Moench) seeds." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B4501467X.

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31

Chen, Haibin. "Study on the relationships between morphologic and molecular structure and fracture toughness of polymers /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?MECH%202002%20CHEN.

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32

McManus, Daniel Charles. "An in vivo approach to the study of apolipoprotein A-I structure-function relationships." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9018.

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Apolipoprotein A-I (apoA-I) is a non-glycosylated 243 amino acid (aa) circulating plasma protein and the major constituent of high density lipoproteins (HDL). To study apoA-I in a physiologically relevant in vivo model, recombinant adenoviruses carrying cDNAs encoding for native human apoA-I (hapoA-I) and different apoA-I mutations were created. This is the first reported use of recombinant adenoviruses to study structure-function relationships of human apoA-I. In the first study, two functional domains within the central region of the protein (aa 100--186) were identified. The results establi

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33

Jones, Deborah Karen. "Structure-function relationships in haem proteins : a comparative study of ascorbate peroxidase and leghaemoglobin." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/30033.

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Ascorbate peroxidase (APX) and leghaemoglobin (Lba) are two highly-specialised haem proteins found in the root nodule of the soybean which maintain homeostasis of oxygen levels. A bacterial expression system was used to generate APX for detailed analyses. Electronic (298K), EPR (7K) and magnetic circular dichroism (MCD) (298K) spectroscopies are consistent with high-spin haem at 298K with small amounts of low-spin species which become more predominant at low temperatures. The reduction potential of the Fe(III)/(II) couple is -159mV, the first reported for an APX. Steady-state kinetics show a s

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34

Ogunsola, Oluwatosin Abiola. "Synthesis of porous films from nanoparticle aggregates and study of their processing-structure-property relationships." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3248.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Chemical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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35

Nowers, Joseph Roden. "A fundamental study of the complex structure-property-processing relationships in interpenetrating polymer networks (IPNs)." [Ames, Iowa : Iowa State University], 2007.

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36

Wu, Yng-Ching, and 吳盈清. "Structure-Activity Relationships of Opioid Ligands:A Molecular Dynamics Study." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/53403459960181750717.

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博士<br>國立成功大學<br>工程科學系碩博士班<br>96<br>The dissertation directs on studying the structure-activity relationships of the various opioid ligands using molecular dynamics simulations and AM1 calculations in order to understand the mechanisms of the active binding interactions between opioid receptors and ligands. It is clear known that morphine is widely used in medicine as strong analgesics for relief of severe pain. Yet, it may cause addiction and withdrawal symptoms as well as other harmful effects. Therefore, since the endogenous opioid peptide of the enkephalin was discovered corresponding to th

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37

"Function/structure relationship study of trichosanthin, a Chinese medicinal protein, and its interaction with acidic ribosomal protein, PO." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074107.

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Previous research showed that the C-terminal tail of TCS can be deleted to generate a mini-TCS (C7-TCS) with antigenicity. The second topic of my study is to resolve the role of the C-terminal of TCS. Structure of C7-TCS showed that deletion of the C-terminal tail destabilizes the protein structure and makes Trp192 more solvent exposed. The relationship between the C-terminal tail and Trp192 was determined by mutating Trp192 to Phe in wild-type TCS and C7-TCS, generating W192F-TCS and W192F-C7-TCS. The crystal structure of C7-TCS, [W192F]-TCS and [W192F]-C7-TCS were determined and compared. Tr

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38

Wang, Han Hsiang, and 王翰翔. "The Structure-Activity Relationships Study of Anti-inflammatory Anthranilate Derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/72250686191916459831.

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碩士<br>長庚大學<br>中醫學系天然藥物<br>98<br>In present study, fifty-four anthranilate derivatives were synthesized and evaluated their inhibitory effects on neutrophils elastase release and superoxide anion generation induced by FMLP. Among them, WHH 34 is more potent than the lead compounds (DXM-RX78 and DSM-RX116) with IC50 value of 0.06 μM. Compounds WHH 50, 51 and 52 shown selectively inhibitory effects on neutrophils elastase release with IC50 values of 0.046, 0.049 and 0.038 μM respectively. The analysis of structure-activity relationships revealed that extending the carbon chain (methyl to butyl) o

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39

"Quantitative structure activity and property study of platinum drugs." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074538.

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Chemical hardness (eta), calculated by density functional theory (DFT), was firstly used as one of the chemical reactivity descriptors to set up the one descriptor 2D-QSAR model of platinum drugs. In this simple but promising model, the antitumour activities (log GI50) evaluated by National Cancer Institute (NCI) of structure-based groups containing normal sp 3 nitrogen and R,R-diamminecyclohexane (R,R-DACH) as the ligand showed good correlation. It was also demonstrated that silane and stereoisomers of DACH groups showed special patterns. This study also made use of the COMPARE program from N

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40

Wang, Wen Hui, and 王雯慧. "The Structure-Activity Relationships Study of Anthranilate Analogs as Neutrophil Elastase Inhibitors." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/00468192387354857993.

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碩士<br>長庚大學<br>中醫學系天然藥物<br>100<br>In chronic inflammation, neutrophil elastase is a major secreted product of stimulated neutrophils and a major contributor to the destruction of tissue in chronic inflammatory disease. Therefore, NE may prove a potential target in the development of new anti-inflammatory agents. In previous study, we synthesis a series anthranilate analogs and evaluate their activities on modulating neutrophil function. The results showed anthranilate analogs exhibiting high selectively inhibitory effects on NE release induced by formyl-L-methionyl-L-leucyl-L-phenylalanine (FML

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41

Chu, Chia-Chun, and 朱佳駿. "Development and Structure-Activity Relationship Study of Antimicrobial Peptides." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/83476448070943069980.

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碩士<br>東海大學<br>化學系<br>104<br>The extensive use of antibiotics in medicine results in the multidrug-resistance of bacteria, making the development of new antimicrobial agents an urgent need. Antimicrobial peptides (AMPs) are considered as a new class of antibiotics with characteristics including an ability to kill target cells rapidly and an unusually broad spectrum of activity. In our previous study, MAP-04-03 was discovered as a potent antimicrobial peptide (MIC= 5 μM), but showed high hemolytic activity (70.7%). In the current study, to increase its antimicrobial activity and reduce the hemol

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Wu, Cheng-Ying, and 吳承穎. "Structure-Activity Relationship Study of Antitumor Aminoindolinesulfonamides and Styrenesulfonamides." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/64200409356436745772.

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碩士<br>臺北醫學大學<br>藥學研究所<br>96<br>The 7-aroyl-aminoindoline-1-benzenesulfonamides developed in our labactory demonstrated excellent anticancer activity, with IC50 values ranging from 9.6~297 nM. For the continuation of structure activity relationship studies on this series, we prepared two classes of indolines, namely 7-(4-methoxy- benzenesulfonylamino)indolines 1-7 and 7-(4-sulfamoylbenzenesulfonyl- amino)indolines 8-12. Data of antiproliferative activity against KB cell line showed that, except for compound 6, most of these series compounds didn’t exhibit substantial cytotoxicity. The secon

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"Structure/function relationship study of trichosanthin and its interaction with mammalian proteins." 1999. http://library.cuhk.edu.hk/record=b6073205.

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Chan Siu Hong.<br>"December 1999."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (p. 172-192).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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44

Du, Zheyuan. "Chemical Stability of Curcumin: Structure and Activity Relationship (SAR) Study." 2016. https://scholarworks.umass.edu/masters_theses_2/347.

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Over the past decades, numerous studies have shown that curcumin has potent biological activities. As a potential chemopreventing agent, curcumin was demonstrated to exert anti-cancer effects in both in vitro and in vivo studies. However, low bioavailability of curcumin limited human clinical trials and its application to be formulated as therapeutics. In this thesis, we will summarize the anti-cancer effects of curcumin in animal studies and clinical trials. In addition, an SAR study will be introduced to elucidate the mechanism of curcumin degradation at physiological pH. We synthesized vari

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45

Chen, I.-Chun, and 陳宜君. "Using Daphnia magna acute toxicity test to study the quantitative structure-activity relationships of organophosphorus pesticides." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/73011095421523394000.

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碩士<br>國立交通大學<br>環境工程系所<br>102<br>This study present the toxicity data of ten organothiophosphorus compounds to Daphnia magna using 48-hours acute toxicity test. Results indicate that Phoxim is the most toxic compound, the reason caused higher toxicity of Phoxim is dependent on its higher charge density due to benzyl cyanide group. Quantitative structure-activity relationships (QSARs) were established between the EC50 values and various molecular descriptors, and a highly predictive two-variable QSAR models were obtained. According to QSAR models, the toxic mechanism was highly re

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46

洪萱芳. "Using a closed-system algal test to study the structure-activity relationships of halogen-substituted aliphatic esters." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/08046244899994245632.

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碩士<br>國立交通大學<br>環境工程系所<br>100<br>This study presents the toxicity data of various halogen-substituted aliphatic esters to Pseudokirchneriella subcapitata. using a closed algal toxicity testing technique with no headspace. Three different response endpoints, i.e., final yield, growth rate, and the dissolved oxygen production were used to evaluate the toxicity of halogen-substituted aliphatic esters. We also use abiotic thiol reactivity (RC50) to establish the QSAR models. Halogen- substituted aliphatic esters toxicity mechanism are classified as electrophiles which are for a subgroup of the SN2

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Lin, Sz-Hung, та 林思宏. "Using a closed-system algal test to study the structure-activity relationships of α,β-unsaturated aldehydes". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/11081449386000652050.

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碩士<br>國立交通大學<br>環境工程系所<br>100<br>A single-cell green algae (Pseudokirchneriella subcapitata) for the toxicity testing species to α,β-unsaturated carbonyl compounds as a test toxic in three reaction endpoints (ΔDO, Final Yield, Growth Rate) on closed system for toxicity testing. The results of QSAR in three reaction endpoints : Log (1/EC50) = 0.965 + 0.968 Log(1/RC50) +0.169 LogKOW r2=0.806 (Δ DO), Log (1/EC50) = 1.200 + 1.000 Log(1/RC50) + 0.113 LogKOW r2=0.832 (Final Yield), Log(1/ EC50) = 0.985 + 0.997 Log(1/RC50) + 0.075 LogKOW r2=0.854(Growth Rate). The QSAR of α,β-unsaturated c

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48

Lin, Chen, and 林辰. "Structure-Activity Relationship Study of 2-Styrylchromones Targeting Carcinoma Cell Lines." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/67045535147119706694.

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碩士<br>淡江大學<br>化學學系碩士班<br>98<br>Previously, we have synthesized a series of 2-styrylchromones that exhibited anticancer effect against carcinoma cells (EJMC, 2009, 44(6), 2552-2562). In this study, we initially focused on the structural modific- ations on B-ring while A-ring was free of substitution. The synthetic route of 2-styrylchromones was carried out in three steps that afforded 52a-q based on the abovementioned work. With seventeen analogs in hand, we examined their growth inhibition on a panel of carcinoma cell lines. Interestingly, 52d, 52l and 52q bearing 4’-methoxy, 3’,4’-difluoro

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Wu, hhuei-mei, and 吳惠美. "Structure Activity Relationship Study of Hydroxypropyl-beta-Cyclodextrin and Substituted Quinolines." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/39877432926998028154.

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碩士<br>台北醫學院<br>藥學研究所<br>88<br>The slopes of phase-solubility diagram of HPCD-quinolines complexes were studied in this thesis. It revealed that most of quinoline derivatives fit the AL type of phase-solubility diagram described by Higuchi and Connors with 1：1 molar ratio complex form. If substituted group was at C4 position, the complexing ability of HPCD was lower than substituted group at C2, C3 or C6 position. If there were disubstituted groups, the solubility and slope were smaller than single substituted group. The hydrophobicity of substituted group affact the increment of solubility. We

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Roy, Myriam. "Structure activity relationship of the myriaporones and biosynthetic study of tedanolide." 2008. http://etd.nd.edu/ETD-db/theses/available/etd-09122008-140910/.

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Thesis (Ph. D.)--University of Notre Dame, 2008.<br>Thesis directed by Richard E. Taylor for the Department of Chemistry and Biochemistry. "September 2008." Includes bibliographical references (leaves 259-269).

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