Academic literature on the topic 'Stupp regimen'

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Journal articles on the topic "Stupp regimen"

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Tanaka, Toshihide, Ryota Tamura, Yohei Yamamoto, et al. "ANGI-01 ALTERATION IN IMMUNE REGULATORY CELLS BEFORE AND AFTER TREATMENT BY STUPP REGIMEN WITH OR WITHOUT BEVACIZUMAB FOR GLIOBLASTOMA." Neuro-Oncology Advances 1, Supplement_2 (2019): ii4—ii5. http://dx.doi.org/10.1093/noajnl/vdz039.019.

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Abstract BACKGROUND In our previous study, bevacizumab (Bev), a humanized anti- vascular endothelial growth factor monoclonal antibody, downregulated the expression of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) immune checkpoint molecules, suppressed the infiltration of immunosuppressing cells such as regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), and induces cytotoxic T lymphocytes (CTL) infiltration. To explore the possibility that inhibition of immunosuppressive cell infiltration and induction of CTL were attributed to not only Bev alone but a
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Zhou, LF, Yu Yao, Shuyuan Yang, et al. "The Stupp regimen preceded by early post-surgery temozolomide versus the Stupp regimen alone in the treatment of patients with newly diagnosed glioblastoma multiforme (GBM)." Journal of Clinical Oncology 31, no. 15_suppl (2013): 2022. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2022.

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2022 Background: In treatment of newly diagnosed GBM with the Stupp chemo-radiotherapy regimen, following by adjuvant chemotherapy, patients were treated with temozolomide (TMZ) & combined radiotherapy 4-5 weeks after surgery. In the interval between surgery and chemo-radiotherapy, it is not known whether additional TMZ treatment will improve efficacy or safety. This trial evaluated the safety and efficacy of the Stupp regimen + early post-surgery TMZ chemotherapy in the treatment of patients with newly diagnosed GBM. Methods: The trial was a multi-center, randomized open-label study. 99 n
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Kazda, T., R. Jancalek, R. Belanova, et al. "P14.101 Glioblastoma survival outcomes related to cortical/neural stem cells regions." Neuro-Oncology 21, Supplement_3 (2019): iii91—iii92. http://dx.doi.org/10.1093/neuonc/noz126.336.

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Abstract BACKGROUND Subventricular brain zone (SVZ) and hippocampal regions are supposed to harbor astrocyte-like neural stem cells. While some tumors may arise from transformed SVZ stem cells, other may be initiated by neo-plastic transformation of non-SVZ progenitor cells or mature glial cells. Lim′s et al classification (Neuro-Oncology 2007) of initial glioblastoma location, related to these neural stem cells regions, was predictive for invasive and multifocal tumor phenotype. The aim of this retrospective single-institutional study is to evaluate the relations of this Lim classification on
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Nishikawa, Ryo. "ACT-25 CLINICAL TRIALS BY THE JCOG BRAIN TUMOR STUDY GROUP." Neuro-Oncology Advances 1, Supplement_2 (2019): ii15. http://dx.doi.org/10.1093/noajnl/vdz039.069.

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Abstract Ongoing brain tumor clinical trials by the Japan Clinical Oncology Group (JCOG) are:JCOG1016, phase III randomized study in patients with anaplastic glioma of radiotherapy with temozolomide versus nimustine hydrochloride (ACNU) followed by temozolomide, is to prove superiority of post-operative radiotherapy with ACNU. JCOG1114, phase III study of high-dose methotrexate and whole brain radiotherapy with or without concomitant and adjuvant temozolomide in patients with primacy CNS lymphoma, is to prove usefulness and get insurance approval of TMZ for primary CNS lymphoma. JCOG1303, rand
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Ilic, Rosanda, Teresa Somma, Dragan Savic, et al. "A Survival Analysis with Identification of Prognostic Factors in a Series of 110 Patients with Newly Diagnosed Glioblastoma Before and After Introduction of the Stupp Regimen: A Single-Center Observational Study." World Neurosurg 104, Aug (2017): 581–88. https://doi.org/10.1016/j.wneu.2017.05.018.

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BACKGROUND: Current treatment protocol for glioblastoma multiforme (GBM) is based on maximal safe resection followed by the Stupp protocol. In Serbia, temozolomide was introduced as adjuvant therapy in 2011. The aims of this study were to confirm the safety and efficacy on overall and progression-free survival of the Stupp protocol and evaluate the influence of prognostic factors in one of the largest series of patients with GBM treated over a 2-year period. METHODS: Between January 2010 and December 2012, 110 patients with newly diagnosed GBM underwent surgical removal at the Neurooncology De
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Chen, Yuanyuan, Guihong Liu, Meihua Li, Liang Wang, Pengfei Sun, and Zhongping Chen. "TIPS-11 EFFICACY AND SAFETY OF STUPP REGIMEN WITH OR WITHOUT ANLOTINIB FOR NEWLY DIAGNOSED GLIOBLASTOMA: INTERIM RESULTS OF A MULTICENTER, DOUBLEBLIND, RANDOMIZED PHASE II TRIAL." Neuro-Oncology Advances 5, Supplement_3 (2023): iii36. http://dx.doi.org/10.1093/noajnl/vdad070.142.

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Abstract BACKGROUND Postoperative radiotherapy with concomitant temozolomide (TMZ) followed by ≤ six cycles of adjuvant TMZ chemotherapy (STUPP regimen) is the standard treatment for newly diagnosed glioblastoma (GBM) with limited effectiveness. Anlotinib inhibits both tumor angiogenesis and tumor cell proliferation by targeting multiple kinases, and showing promising results in preclinical GBM models and phase I clinical trials. We designed a phase II trial to verify the efficacy and safety of the STUPP regimen plus anlotinib (NCT 04959500). METHODS This is a multicenter, double-blind, random
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Liu, Yang, Myla Strawderman, Kwanza Warren, et al. "INNV-09. CLINICAL EFFICACY OF TUMOR TREATING FIELDS FOR NEWLY DIAGNOSED GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi132. http://dx.doi.org/10.1093/neuonc/noz175.552.

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Abstract Recent clinical trials demonstrated that adding tumor treating fields (TTF) to radiotherapy and temozolomide chemotherapy (the Stupp protocol) increased survival for glioblastoma (GBM) patients. However, data is lacking on the magnitude of this survival effect when the regimen is used outside of a clinical trial as part of routine clinical practice. In the present study, we retrospectively identified adult patients with newly diagnosed GBM (n = 240) treated with the Stupp protocol at our institution from January 2005 to July 2017. We grouped patients into two time periods for comparis
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Perlow, Haley, Michael Yang, Brett Klamer, et al. "CTNI-37. ISOEFFECTIVE HYPOFRACTIONATION FOR ELDERLY OR FRAIL PATIENTS WITH A NEWLY DIAGNOSED GLIOBLASTOMA: A POOLED INTERNATIONAL STUDY." Neuro-Oncology 23, Supplement_6 (2021): vi67—vi68. http://dx.doi.org/10.1093/neuonc/noab196.262.

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Abstract PURPOSE The standard of care (SOC) for elderly or frail glioblastoma (GBM) patients is 40 Gy in 15 fraction radiotherapy. However, this regimen has a lower BED compared to the Stupp regimen, 60 Gy in 30 fractions. We hypothesize that isoeffective hypofractionated radiation of 52.5 Gy in 15 fractions (BED equivalent to Stupp) will have superior survival compared to standard of care. METHODS Elderly GBM patients treated with 52.5 Gy in 15 fractions were pooled from 2 phase II studies, 1 phase 1 and a prospective observation study. Overall survival (OS) and progression free survival (PFS
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Chen, Y., G. Liu, P. Sun, et al. "P27.07.A EFFICACY AND SAFETY OF STUPP REGIMEN WITH OR WITHOUT ANLOTINIB FOR NEWLY DIAGNOSED GLIOBLASTOMA: A MULTICENTER, DOUBLE-BLIND, RANDOMIZED PHASE II TRIAL." Neuro-Oncology 26, Supplement_5 (2024): v137—v138. http://dx.doi.org/10.1093/neuonc/noae144.469.

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Abstract BACKGROUND The STUPP regimen, which consists of postoperative radiotherapy with concurrent temozolomide (TMZ) followed by up to six cycles of adjuvant TMZ chemotherapy, is the established standard treatment for newly diagnosed glioblastoma (GBM). However, its effectiveness is limited. Anlotinib, a multi-kinase inhibitor targeting tumor angiogenesis and cell proliferation, has demonstrated promising results in preclinical GBM models and phase I clinical trials. In order to assess the efficacy and safety of combining the STUPP regimen with anlotinib, we conducted a phase II trial aimed
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Miyake, Keisuke, Tomono Fuke, Masaki Tatano, et al. "NI-16 RESPONSE ASSESSMENT OF BEVACIZUMAB THERAPY FOR GLIOBLASTOMA BY USING MULTIPLE PET TRACERS." Neuro-Oncology Advances 4, Supplement_3 (2022): iii18. http://dx.doi.org/10.1093/noajnl/vdac167.067.

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Abstract Objective PET scans are useful for the diagnosis and treatment planning of glioma. Introduced in 2013, bevacizumab (Bev) treatment efficacy can be difficult to determine using MRI imaging. We instead performed PET scans to determine the efficacy of Bev-based glioblastoma treatment. Methods Eighty glioblastoma patients treated with Bev from July 2013 to December 2021 were included. The patients were divided into the following three groups: the first group received Bev added to the Stupp regimen after biopsy or subtotal resection (first-dose group), the second group received Bev added t
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Dissertations / Theses on the topic "Stupp regimen"

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Ramantswana, Mufhumudzi Muedanyi. "A comparison of harvester productivity and stump volume waste in coppiced and planted eucalyptus grandis pulpwood compartments in the KwaZulu-Natal forestry region of South Africa." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1019844.

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Over the past decade the South African forestry industry has gradually experienced the ramifications of labour scarcity, increases in labour costs, the effect of HIV and AIDS and increasing timber demand. Consequently, this has led to an increase in the mechanisation rate, especially in timber harvesting operations. Due to the labour challenges in South Africa, mechanised forestry equipment has increasingly been required to operate in complex forest conditions, such as coppiced compartments, where they have not operated before. It therefore occurs that harvesters are either used in certain cop
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Books on the topic "Stupp regimen"

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Olivieri, Luca M. Stoneyards and Artists in Gandhara The Buddhist Stupa of Saidu Sharif I, Swat (c. 50 CE). Fondazione Università Ca’ Foscari, 2022. http://dx.doi.org/10.30687/978-88-6969-578-0.

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The book advances a hypothetical reconstruction of the planning and programming of the building site, the executive process, the construction and decoration, and ultimately the deconsecration and abandonment of an ancient Buddhist stupa in Gandhara. The chronological context is the mid-first to the early fourth century CE. The stupa is located near the town of Saidu Sharif in the fertile and rich Swat valley, a northern region of ancient Gandhara (today in Pakistan). The study is based on archaeological excavation data conducted at the site over several seasons. The narrative frieze of the stu
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Book chapters on the topic "Stupp regimen"

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Veldhuis Anouk, Sent Danielle, Bruin-Huisman Linette, Beers Erna, and Abu-Hanna Ameen. "The Association Between the STOPP/START Criteria and Gastro-Intestinal Track Bleedings in Elderly Patients." In Studies in Health Technology and Informatics. IOS Press, 2017. https://doi.org/10.3233/978-1-61499-753-5-569.

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Potentially inappropriate prescribing is a common problem, especially in elderly care. To tackle this problem, Irish medical experts have developed a list of criteria when medication should be added or omitted based upon the patient's physical condition and medication use, known as the STOPP and START criteria. The STOPP and START criteria have been formulated to identify the prescribing of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs). One of the most common problems of inappropriate prescribing is gastro-intestinal track bleedings. For this purpose, ni
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Bamber, David James, and Clay Alex Gransden. "Perfume Consumption in India." In Exploring the Dynamics of Consumerism in Developing Nations. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7906-9.ch004.

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Perfumes have been important in India for millennia and so have the stories connected with them. The perfume business in India is worth billions ($). A background from which the Indian perfume industry can be understood in terms of the Berger's STEPP model, the consumers' cognitive schemas, consumers' behaviors, and the story of the product, brand, and their customers' stories. Three sets of themes—product perceptions, concerns, and consumers' lifestyle—are identified, each with their own sub-themes that are antecedents to perfume purchasing behavior. Segments in the Indian perfume market are
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Robinson, Michael D. "What Ought Patriots to Do?" In Union Indivisible. University of North Carolina Press, 2017. http://dx.doi.org/10.5149/northcarolina/9781469633787.003.0005.

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This chapter explains the development of the Unionist Offensive, which was an effort by Border South moderates to sustain the region’s pro-Union mind-set in the weeks after the election of Republican Abraham Lincoln. Although the election of 1860 had proven that many white border southerners continued to espouse a preference for moderate politics, Unionists rightfully worried that pro-secession sentiment would spread rapidly in the region, especially after many Lower South states called conventions to consider secession. Led by Kentucky Senator John Jordan Crittenden, the Unionist Offensive wa
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Kulenovic, Adnan, and Azra Lagumdzija-Kulenovic. "Minimizing STOPP and Beers Criteria Risks in PIM Treatments Using PM-TOM and ChatGPT: A Case Study." In Studies in Health Technology and Informatics. IOS Press, 2025. https://doi.org/10.3233/shti250067.

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PM-TOM (Personalized Medicine-Therapy Optimization Method) is a clinical decision-support tool designed to optimize polypharmacy treatments by minimizing their adverse drug reactions (ADRs) caused by individual drugs or drug interactions (DDIs, DCIs, DFIs, DGIs), along with the risks identified by the STOPP and Beers criteria. On the other hand, AI tools like ChatGPT 4.0, trained on medical literature texts, can provide broader clinical reasoning and insights tailored to individual patient contexts. By referring to a documented deprescribing case, this study demonstrates the synergistic power
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Kost, Fiona. "Burning the Bush: The Development of Australia’s Southwest Botanical Province." In Humans and the Environment. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199590292.003.0015.

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Though early historical records frequently mention Aboriginal, or Noongar, firing in south-western Australia, little is known about how the Noongar people managed the vegetation with fire, or the impact this has had on the environment. This study uses interdisciplinary archaeology, with information from ethnographic data, historical records, and pollen records from the last 6,000 years to determine the actions of the Noongar people and demonstrate how the Southwest Botanical Province can be viewed as an artefact of Noongar land management. It is widely accepted that Aboriginal people have had
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Oma, Kristin Armstrong. "Past and Present Farming: Changes in Terms of Engagement." In Humans and the Environment. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199590292.003.0020.

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In archaeology, changes in human–animal relationships are rarely considered beyond the moment of domestication. This is influenced by Ingold’s idea that domestication led to a shift in the human engagement with animals (Ingold 2000: 61–76; see Armstrong Oma 2007: 62–4, 2010 for critique). I do not question the validity of such a claim; however, I argue that changes in terms of engagement also happened beyond domestication, and that various configurations of human–animal relationships have existed throughout history. Further, I argue that such changes also have consequences for the environment,
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Conference papers on the topic "Stupp regimen"

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Dziegielewski, Jaroslaw, Barbara Dziegielewska, and Lloyd S. Gray. "Abstract 1808: Enhancing the Stupp regimen in glioblastoma cancer cells with a T-type calcium channels inhibitor." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1808.

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Elkin, Benjamin S., and Barclay Morrison. "Region-Specific Tolerance Criteria for the Living Brain." In 51st Stapp Car Crash Conference. SAE International, 2007. http://dx.doi.org/10.4271/2007-22-0005.

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Allsop, Douglas L., Thomas R. Perl, and Charles Y. Warner. "Force/Deflection and Fracture Characteristics of the Temporo-parietal Region of the Human Head." In Stapp Car Crash Conference. SAE International, 1991. http://dx.doi.org/10.4271/912907.

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Fijalkowski, Ronald J., Narayan Yoganandan, Jiangyue Zhang, and Frank A. Pintar. "A Finite Element Model of Region-Specific Response for Mild Diffuse Brain Injury." In 53rd Stapp Car Crash Conference. SAE International, 2009. http://dx.doi.org/10.4271/2009-22-0007.

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Prange, Michael, and David F. Meaney. "Defining Brain Mechanical Properties: Effects of Region, Direction, and Species." In 44th Stapp Car Crash Conference (2000). SAE International, 2000. http://dx.doi.org/10.4271/2000-01-sc15.

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Rotariu, Mariana, Catalin Ionite, Andrei Gheorghita, and Dragos Arotaritei. "DETERMINATION OF GEOMETRICAL PARAMETERS THAT CHARACTERIZE TRANSFEMURAL STUMP." In eLSE 2017. Carol I National Defence University Publishing House, 2017. http://dx.doi.org/10.12753/2066-026x-17-258.

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It is essential to evaluate the volume and the size of the residual limb in order to design and implement a high-quality prosthesis, which can ensure optimal patient comfort. There is a wide collection of articles dealing with this issue. The blunt point wears out over time in terms of volume in the sense of growth - edema and in the sense of decrease - atrophy. The assessment of wear and tear over time of the contact surfaces belonging to blunt-prosthesis joint, as well as the tribological implications concerning the durability and damage of the prosthesis are absolutely necessary. The damage
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Ni, Weijian, Bo Xu, Amos Martinez, Sze Yun Set, and Shinji Yamashita. "Simplified all-polarization maintaining fiber laser mode-locked in the all-normal dispersion regime." In CLEO: Science and Innovations. OSA, 2016. http://dx.doi.org/10.1364/cleo_si.2016.stu3p.4.

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Yoganandan, Narayan, John R. Humm, Frank A. Pintar, and Karen Brasel. "Region-Specific Deflection Responses of WorldSID and ES2-re Devices in Pure Lateral and Oblique Side Impacts." In 55th Stapp Car Crash Conference. SAE International, 2011. http://dx.doi.org/10.4271/2011-22-0013.

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Sakurai, Minoru. "An Analysis of Injury Mechanisms for Ankle/Foot Region in Frontal Offset Collisions." In 40th Stapp Car Crash Conference (1996). SAE International, 1996. http://dx.doi.org/10.4271/962429.

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Čakšs, Roberts, and Baiba Jansone. "Long term effects of total biomass harvesting on understory vegetation and tree stand in Norway spruce stands." In Research for Rural Development 2023 : annual 29th international scientific conference proceedings. Latvia University of Life Sciences and Technologies, 2023. http://dx.doi.org/10.22616/rrd.29.2023.006.

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Northern Europe will be one of the locations where the renewable energy from forests could displace fossil fuels as a result of climate change: therefore, it will become more crucial to maintain renewable materials that also collect CO2. By taking tree biomass out of forest stands, we could create more renewable resources to use in practice, but this has certain negative effects on the forest ecology, including nitrogen leaching and vegetation degradation. The goal of the study is to investigate the effects of full biomass removal (FBR) in Norway spruce (Picea abies (L.) H. Karst.) forest stan
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