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Dissertations / Theses on the topic 'Subcellular Localization'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Schlehe, Julia. "Folding, function and subcellular localization of parkin." Diss., kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9266/.

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2

Winsnes, Casper. "Automatic Subcellular Protein Localization Using Deep Neural Networks." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-189991.

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Protein localization is an important part in understanding the functionality of a protein. The current method of localizing proteins is to manually annotate microscopy images. This thesis investigates the feasibility of using deep artificial neural networks to automatically classify subcellular protein locations based on immunoflourescent images. We investigate the applicability in both single-label and multi-label classification, as well as cross cell line classification. We show that deep single-label neural networks can be used for protein localization with up to 73% accuracy. We also show

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3

Hogenboom, Sietske. "Subcellular localization of the human isoprenoid biosynthesis pathway." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/76236.

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4

Hogan, Angela. "Syntrophin regulates the subcellular localization of diacylglycerol kinase-zeta." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26490.

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Syntrophins are scaffolding proteins that link signaling molecules to the dystrophin protein complex at the plasma membrane. To further understand the roles of syntrophins a yeast two-hybrid screen of a human brain cDNA library was done using the PDZ domain of the recently identified brain-specific gamma 1-syntrophin, an isoform for which no signaling ligands had yet been identified. This screen yielded ten overlapping clones coding for the C-terminal portion of diacylglycerol kinase-zeta (DGK-zeta), a kinase that phosphorylates the membrane lipid diacylglycerol (DAG) to phosphatidic acid (PA)

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5

Laquian, Ian R. "Inquiries into the subcellular localization of the glucocorticoid receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/MQ48162.pdf.

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6

Manchen, Steven T. "Characterization and subcellular localization of the human BAT3 protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62248.pdf.

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7

Svartz, Jesper. "Leukotriene C₄ synthase : studies on oligomerization and subcellular localization /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med913s.pdf.

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8

Vargas-Vallejo, Leonardo. "Subcellular localization and signaling of Bruton's tyrosine kinase (Btk) /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-344-9/.

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9

Stadler, Charlotte. "Towards subcellular localization of the human proteome using bioimaging." Doctoral thesis, KTH, Proteomik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103616.

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Since the publication of the complete sequence of the human genome in 2003 there has been great interest in exploring the functions of the proteins encoded by the genes. To reveal the function of each and every protein, investigation of protein localization at the subcellular level has become a central focus in this research area, since the localization and function of a protein is closely related. The objective of the studies presented in this doctoral thesis was to systematically explore the human proteome at the subcellular level using bioimaging and to develop techniques for validation of

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10

Mullins, M. "Subcellular localization of metals in metal tolerant higher plants." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384378.

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11

Kilstrup-Nielsen, Charlotte. "Molecular mechanisms underlying the regulation of PBX subcellular localization." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402326.

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12

Davies, Kurtis Daniel. "Protein phosphorylation : roles in subcellular localization and synaptic plasticity /." Connect to abstract via ProQuest. Full text is not available online, 2008.

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13

Ozarar, Mert. "Prediction Of Protein Subcellular Localization Based On Primary Sequence Data." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/1082320/index.pdf.

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Subcellular localization is crucial for determining the functions of proteins. A system called prediction of protein subcellular localization (P2SL) that predicts the subcellular localization of proteins in eukaryotic organisms based on the amino acid content of primary sequences using amino acid order is designed. The approach for prediction is to nd the most frequent motifs for each protein in a given class based on clustering via self organizing maps and then to use these most frequent motifs as features for classication by the help of multi layer perceptrons. This approach allows a classic

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14

Pereira, Jorge. "Characterization of the subcellular localization of Sirtuin 2 during infection with Listeria monocytogenes." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC313.

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Listeria monocytogenes est l'un des meilleurs organismes modèles pour l'étude des interactions bactérie-hôte. Ce pathogène intracellulaire facultatif peut infecter, survivre et se répliquer dans le cytoplasme des cellules eucaryotes, démontrant la co-évolution étroite de Listeria avec son hôte. Le style de vie intracellulaire de ce pathogène implique la manipulation de divers composants de la cellule hôte, dont l'un est la chromatine. En induisant des modifications de la chromatine au niveau des histones, Listeria peut influencer le programme transcriptionnel de l'hôte. Ce projet de thèse port

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15

Alvestad, Rachel Marie. "Phosphorylation and subcellular localization of NMDA receptors : modulation by ethanol /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 145-170). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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16

Bozkurt, Burcin. "Prediction Of Protein Subcellular Localization Using Global Protein Sequence Feature." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/3/1135292/index.pdf.

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The problem of identifying genes in eukaryotic genomic sequences by computational methods has attracted considerable research attention in recent years. Many early approaches to the problem focused on prediction of individual functional elements and compositional properties of coding and non coding deoxyribonucleic acid (DNA) in entire eukaryotic gene structures. More recently, a number of approaches has been developed which integrate multiple types of information including structure, function and genetic properties of proteins. Knowledge of the structure of a protein is essential for describi

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17

Bezek, Perit. "A Clustering Method For The Problem Of Protein Subcellular Localization." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607981/index.pdf.

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In this study, the focus is on predicting the subcellular localization of a protein, since subcellular localization is helpful in understanding a protein&rsquo<br>s functions. Function of a protein may be estimated from its sequence. Motifs or conserved subsequences are strong indicators of function. In a given sample set of protein sequences known to perform the same function, a certain subsequence or group of subsequences should be common<br>that is, occurrence (frequency) of common subsequences should be high. Our idea is to find the common subsequences through clustering and use these comm

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18

Alay, Gokcen. "A Classification System For The Problem Of Protein Subcellular Localization." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608914/index.pdf.

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The focus of this study is on predicting the subcellular localization of a protein. Subcellular localization information is important for protein function annotation which is a fundamental problem in computational biology. For this problem, a classification system is built that has two main parts: a predictor that is based on a feature mapping technique to extract biologically meaningful information from protein sequences and a client/server architecture for searching and predicting subcellular localizations. In the first part of the thesis, we describe a feature mapping technique based o

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19

Kargoll, Sabrina [Verfasser]. "Synthetic Sphingolipid analogues biophysical properties and subcellular localization / Sabrina Kargoll." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1105424626/34.

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20

Huang, He 1972. "Regulating hox cofactors function via subcellular localization and transcriptional activity." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84260.

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HOX proteins are evolutionarily conserved homeodomain (HD)-containing transcription factors that mediate environmental signal cues and specify regional identities. PBC (including EXD in Drosophila and PBX in vertebrates) and MEIS/PREP proteins are two families of transcription factors within the broader three-amino-acid-loop-extension (TALE) class of homeoproteins. They form cooperative DNA-binding complexes with HOX proteins and have been shown to assist HOX functional specificity and participate in HOX-mediated transcriptional regulation.<br>The function of HOX cofactors is regulated

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21

Richard, Travis. "ARK5 Regulates Subcellular Localization of hnRNP A1 During Hypertonic Stress." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36212.

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During cellular stress, the regulation of protein synthesis is a key adaptive mechanism used by cells to survive. In response to various stresses, heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), an RNA binding protein principally found within the nucleus, is phosphorylated and consequently accumulates in the cytoplasm. Among other roles, cytoplasmic hnRNP A1 functions as an auxiliary translation factor for internal ribosome entry site (IRES)-mediated translation of specific mRNA, including the anti-apoptotic protein B-cell lymphoma-extra large (Bcl-xL). To identify which kinases control

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22

Saslowsky, David. "Molecular Genetics and Subcellular Localization of Flavonoid Metabolism in Arabidopsis." Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/29929.

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There are at least two models describing how the enzymes of metabolic pathways are arranged in living cells. The first is a stochastic model, where enzymes are freely-diffusing in the aqueous environment of the cell, and the second, the metabolon model, has pathway enzymes organized as enzyme complexes. Both are valid scientific hypotheses in that they make predictions that can be tested regarding pathway regulation, localization, and function. The goal of the work presented here was to test the metabolon model using the flavonoid biosynthetic pathway in Arabidopsis, which has been hypothes

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23

Das, Sanjeev. "Subcellular Localization of Tobacco SABP2 under Normal and Stress Conditions." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/569.

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Subcellular Localization of Tobacco SABP2 under Normal and Stress Conditions Salicylic acid (SA), a phytohormone, plays an important role in plant physiology. SA mediated innate immune pathway is an important pathway for plant immunity against pathogens. Plants resisting pathogen infection synthesize higher levels of Methyl Salicylate (MeSA), which is then converted to SA by the esterase activity of Salicylic Acid Binding Protein 2 (SABP2). The high level of the converted SA leads to enhanced pathogen resistance. The study of subcellular localization of a protein is critical in explaining its

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24

Bian, Feng. "Molecular analysis of subcellular mRNA localization in cerebellar purkinje cells /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948807588657.

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25

Richter, Catherine Ann. "Regulation of subcellular localization of the aryl hydrocarbon receptor (AHR)." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcitt?p9988694.

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26

Styles, Nathan Allen. "The characterization of the subcellular localization of bile acid CoA:N-acyltransferase." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/styles.pdf.

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27

Weist, Ryan. "Molecular determinants for differential subcellular localization of class IIa histone deacetylases." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106613.

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Histone deacetylases (HDACs) are members of an important family of enzymes that govern acetylation of histone and non-histone proteins in many biological processes. HDAC4, -5, -7 and -9, members of class IIa, share a unique tripartite structure enabling them to function as signal-responsive transcriptional modulators. Phosphorylation of their conserved serine residues leads to 14-3-3 protein-dependent nucleocytoplasmic shuttling and regulation of HDAC-mediated transcriptional control. In addition, intrinsic nuclear import and export signals actively dictate the subcellular localization of thes

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28

Boerboom, Derek. "Subcellular localization and substrate specificity of the protein-tyrosine phosphatase MPTP." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22850.

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In order to study the subcellular localization of the protein-tyrosine phosphatase MPTP, indirect immunofluorescence microscopy experiments were performed. The enzyme was thereby determined to localize almost exclusively to the nucleus. The nuclear localization signal was mapped by further immunofluorescence experiments performed with deletion mutants and $ beta$-galactosidase fusion constructs. The sequence $ rm sp{345}RKRIRED sp{351}$ was found to be capable and sufficient to localize MPTP and unrelated proteins to the nucleus, and a secondary domain was identified that is likely involved in

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29

Hirata, Takashi. "Analysis of molecular mechanisms controlling subcellular localization of ABCG5 and ABCG8." Kyoto University, 2011. http://hdl.handle.net/2433/142331.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第16133号<br>農博第1869号<br>新制||農||990(附属図書館)<br>学位論文||H23||N4603(農学部図書室)<br>28712<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授矢﨑一史<br>学位規則第4条第1項該当

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30

Fai, Leonard Yenwong. "Subcellular Localization of Tobacco Salicylic Acid Binding Protein 2 in Plants." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1274.

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Salicylic Acid Binding Protein 2 (SABP2) is a 29kDa protein present in extremely low amounts in tobacco leaves. SABP2 processes the mobile defense signal, methyl salicylic acid generated in plants resisting microbial infection. The precise localization of SABP2 in plants is not known. SABP2 has not been shown to have any targeting signal peptides. This study was designed to determine localization of SABP2 in tobacco plants. Biochemical and immunological studies using antibodies against SABP2 suggest that it is localized to the chloroplast, associating with chloroplast envelope membranes. Chlor

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31

Samuel, Linoj Philip. "Immunogenicity, Subcellular Localization And Function Of the Eis Protein Of Mycobacterium tuberculosis." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1205%5F1%5Fm.pdf&type=application/pdf.

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32

Fang, Jun. "Signals regulating the subcellular localization of the TALE partners PBX1 and MEIS1." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18305.

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In vertebrates, PBX and MEIS/PREP are normally localized to the cytoplasm and are mutually dependant on one another for their translocation to the nucleus. Recently, phosphorylation and cytoskeleton anchoring to myosin heavy chain II B were proposed as regulatory factors for PBX subcellular localization. Moreover, MEIS-independent regulation of PBX1 subcellular localization has also been reported. In this study, we investigated the role of actin and myosin in the control of PBX1 subcellular localization and the PBX1-independent regulation of MEIS1 subcellular localization. Our data suggest tha

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33

Tan, Fui Ching. "Isolation of genes and subcellular localization of tetrapyrrole biosynthetic enzymes from Arabidopsis." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621320.

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34

Arioka, Yuko. "Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/174995.

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35

Al-Gharably, Naji Mohammed. "The subcellular localization, fate and handling of cardiac glycosides by HeLa cells." Thesis, University of St Andrews, 1986. http://hdl.handle.net/10023/14228.

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The subcellular fate of ouabain digoxin and digitoxin after binding to HeLa cell surface was studied using a conventional ultracentrifugation technique, Ouabain, digoxin and digitoxin codistributed with the plasma membrane marker 5'-nucleotidase immediately after bindings and cells chilled at 2°C for 24 hours retained ouabain in the plasma membrane fractions with time these glycosides are internalized to a subcellular compartment apparently the lysosomes. Internalized ouabain showed a distribution pattern throughout the linear sucrose gradient which was similar to that of the lysosomal marker

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36

Sriparameswaran, Anuja. "Subcellular Localization of N-acylphosphatidyl-ethanolamine Synthase in Cotyledons of Cotton Seedlings." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278717/.

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N-acylation of phosphatidylethanolamine (PE) with free fatty acids catalyzed by N-acyl phosphatidylethanolamine (NAPE) synthase was reported in cotyledons of 24-h-old cotton seedlings. Here I report subcellular localization of this enzyme. Differential centrifugation, sucrose density gradient fractionation,aqueous two-phase partitioning and electron microscopy techniques were utilized to elucidate subcellular site(s) of NAPE synthase. Marker enzymes were used to locate organelles in subcellular fractions. Differential centrifugation indicated that NAPE synthase is present in more than one orga

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37

Golub, Ognjen. "Molecular Mechanisms Regulating Subcellular Localization and Function of Mitotic Spindle Orientation Determinants." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20711.

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Proper orientation of the mitotic spindle is essential during animal development for the generation of cell diversity and organogenesis. To understand the molecular mechanisms regulating this process, genetic studies have implicated evolutionarily conserved proteins that function in diverse cell types to align the spindle along an intrinsic cellular polarity axis. This activity is achieved through physical contacts between astral microtubules of the spindle and a distinct domain of force generating proteins on the cell cortex. In this work, I shed light on how these proteins form distinct cort

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38

Femia, Matthew Robert. "Subcellular Localization Dynamics of Thyroid Hormone Receptor and Mediator Complex Subunit 1." W&M ScholarWorks, 2017. https://scholarworks.wm.edu/etd/1530192345.

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Intracellular trafficking of transcription factors is an essential cellular function that has implications in regulating gene expression. For thyroid hormone receptor (TR), nuclear localization is fundamental to its function of mediating gene expression in response to thyroid hormone (T3). Yet, we’ve previously shown that TR contains both nuclear localization signals and nuclear export signals, and shuttles rapidly between the nucleus and cytosol. Mislocalization of TR, and loss of transcriptional control, may lead to negative consequences for growth, development, and metabolism. Here, we expl

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39

Hattori, Kimihiko, Shinji Hayano, and Hisao Seo. "Expression of ZAKI-4 in Mammalian Cells." Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7558.

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40

Breitkreuz, Kevin Edmund. "Subcellular localization of gamma-aminobutyrate metabolism and transport of gamma-aminobutyrate in plants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/NQ40365.pdf.

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41

Fawcett, James P. "The subcellular localization and function of endogenous BDNF in the adult rat CNS." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ55329.pdf.

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42

Jérôme, Myrka. "Regulation of protein phosphatase 1 alpha subcellular localization by 14-3-3 zeta." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96956.

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Protein phosphatases have several substrates that are involved in many processes in mammalian cells such as glycogen metabolism, cell cycle progression, cell differentiation, apoptosis, protein synthesis and signal transduction (Cohen, 2002; Berndt, 1999; Shenolikar, 1994) The alpha isoform of protein phosphatase 1 (PP1) may play a significant role in neuronal differentiation. While the extent of phosphorylation of PP1 has been shown to affect the degree of differentiation of nerve growth factor (NGF)-treated PC12 cells, it is not known whether phosphorylation of PP1 alpha is needed for its i

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43

Shashidhara, L. S. "Porphobilinogen deaminase from Euglena gracilis : expression, subcellular localization, regulation, and targeting to plastids." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239204.

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44

Leighton, Margaret Janet. "The accumulation and subcellular localization of copper in the liver of foetal deer." Thesis, Royal Veterinary College (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519519.

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45

Brooks, Paul. "Subcellular localization, induction by #gamma#-interferon and purification of the proteasome activator PA28." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324332.

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46

Zhang, Wenting. "Regulation of neuronal gene expression through changes in subcellular localization of transcriptional regulators." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608902.

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47

Quiñones-Frías, Mónica C. (Mónica Cristina). "Characterization of synaptotagmin 7 function in neurotransmission and its subcellular localization at synapses." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127136.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, May, 2020<br>Cataloged from the official PDF of thesis.<br>Includes bibliographical references.<br>Synaptic vesicle (SV) fusion is dependent on proteins that can sense Ca²⁺ and trigger fusion with the plasma membrane. Neurotransmitter release occurs during a rapid synchronized phase of SV fusion mediated by the Ca²⁺ sensor Synaptotagmin 1 (SYT1). A slower SYT1-independent asynchronous phase is also present at many synapses and has been hypothesized to be mediated by another Synaptotagmin, SYT7. To determine if SYT7 p

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48

Aljagthmi, Amjad Ahmed. "The regulation of small GTPase Rac1 phosphorylation, activation and subcellular localization by ΔNp63α". Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1629746909185699.

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49

Miura, Natsuko. "Studies on subcellular localization of a moonlighting protein, enolase, and its foci formation." Kyoto University, 2013. http://hdl.handle.net/2433/175049.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第17620号<br>農博第1982号<br>新制||農||1009(附属図書館)<br>学位論文||H25||N4741(農学部図書室)<br>30386<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田充美, 教授喜多恵子, 教授小川順<br>学位規則第4条第1項該当

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50

Giang, Kayla. "Investigation of substrate phosphorylation by and subcellular localization of SR protein kinase 1." Diss., [La Jolla, Calif.] : University of California, San Diego, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1457285.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed Nov. 13, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 112-117).

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