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Journal articles on the topic 'Sublingual Drug'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Gadekar, Nilesh Shivaji, Sakshi Machhindra Gaikwad, and Swati Bhagwan Katkar. "Review on Sublingual Tablet." International Journal for Research in Applied Science and Engineering Technology 12, no. 1 (2024): 1358–63. http://dx.doi.org/10.22214/ijraset.2024.58175.

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Abstract: Objective: As sublingually given dose forms avoid hepatic metabolism, sublingual medication delivery can be an alternate and superior method to oral drug delivery. For some medications, particularly those prescribed for the treatment of acute diseases, a quick onset of pharmacological activity is frequently required. Sublingual pills dissolve quickly, and the major saliva available is typically enough to achieve dosage form disintegration along with enhanced dissolving and increased bioavailability. Findings: Comparing sublingual pills to traditional dosage forms, it was discovered t

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2

Saha, Puja, Sushma Verma, and Pratik Swarup Das. "SUBLINGUAL DRUG DELIVERY: AN INDICATION OF POTENTIAL ALTERNATIVE ROUTE." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 5. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23436.

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Sublingual literally meaning is “under the tongue”, refers to a method of administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. Sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally ingested tablets. Drugs that are given sublingually reach directly in to the systemic circulation through the ventral surface of the tongue and floor of the mouth. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving accepta

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3

Ashok, Kumar Sharma, Pushpendra Singh Naruka Dr., Shankar Soni Mr., Mohit Khandelwal Mr., Shaneza Aman Ms., and Mehul Mr. "SUBLINGUAL TABLET- ADVANCEMENT IN TABLET DOSAGES FORM." International Journal of Current Pharmaceutical Review and Research 11, no. 2 (2019): 01–05. https://doi.org/10.5281/zenodo.12672960.

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Sublingual drug delivery is often an alternate and better choice of route in comparison to oraldrug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapidonset of pharmacological effect is usually desired for a few drugs, especially those utilizedin the treatment of acute disorders and need onset of action. Sublingual tablets disintegraterapidly and therefore the bit of saliva present is typically sufficient for achievingdisintegration of the dosage form including better dissolution and increased bioavailabilitywith effective therapeutic range. Sublingual tablets

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Pawar, Poonam P., Hemant S. Ghorpade, and Bhavana A. Kokane. "Sublingual route for systemic drug delivery." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 340–43. http://dx.doi.org/10.22270/jddt.v8i6-s.2097.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in geriatric, pedi

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Aravindhanthan V, Anjali P B, and Arun Radhakrishnan. "Sublingual spray: a new technology oriented formulation with multiple benefits." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 2875–85. http://dx.doi.org/10.26452/ijrps.v10i4.1567.

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Sublingual drug delivery system was a well-established platform for delivering the drug that need to exhibit quick action without any first-pass metabolic effect, but various pitfall in the regular sublingual drug delivery systems such as a tablet, capsule etc., that can be overcome by novel sublingual drug delivery technology such as particulate sublingual spray. Sublingual spray for drug administration has gained attention in the market since it proved its propensity to by-pass the first-pass metabolism and to initiate a rapid onset of action due to its atomized micro particulate nature, whi

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Labhade, Sanjana, Chaitali Malode, Vaishali Rawal, and Smita Rupvate. "Review on Sublingual Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 684–88. http://dx.doi.org/10.22270/jddt.v9i3.2684.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally administered drugs. In terms of permeability, the sublingual area of the oral cavity is more permeable than the buccal area, which in turn is more permeable than the roof of the mouth area. The portion of drug absorbed through the sublingual blood vessels avoids hepatic first‐pass metabolic processes giving good bioavailability. Sublingual technology for patients need enhanced life

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7

Het, Patel*, Patel Jaini, Ghanshyam Patel Dr., Yadav Priyanka, and Divykant Patel Dr. "REVIEW-SUBLINGUAL ROUTE FOR SYSTEMIC DRUG DELIVERY." World Journal of Pharmaceutical Science and Research 2, no. 2 (2023): 45–57. https://doi.org/10.5281/zenodo.10894235.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in ger

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8

Himanshi, Rathaur* and G.Gnanarajan. "REVIEW ON: SUBLINGUAL ROUTE FOR SYSTEMIC DRUG DELIVERY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 453–62. https://doi.org/10.5281/zenodo.1161209.

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Delivery of drug in the oral cavity through the oral mucosa is examined to be a promising alternative to the oral route. Sublingual means “under the tongue” which rapidly absorb the drug through the oral mucosa and enter into the systemic circulation. This route provides various advantages such as quick onset of action, patient compliance, hepatic first pass metabolism and increase bioavailability. Dysphagia is a common problem in pediatric, geriatric and psychiatric patients. In terms of permeability sublingual area of oral cavity is more permeable than buccal area which is in tur

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9

Goswami, Tarun, Bhaskara R. Jasti, and Xiaoling Li. "Sublingual Drug Delivery." Critical Reviews in Therapeutic Drug Carrier Systems 25, no. 5 (2008): 449–84. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v25.i5.20.

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10

Kumar, Damit, Amit Sharma, and Rajiv Garg. "FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF LOSARTAN POTASSIUM." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 54–66. http://dx.doi.org/10.22270/ajprd.v6i4.386.

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The objective of the current study was to develop and optimize a sublingual tablet of Losartan potassium, which is an effective drug in the treatment of hypertension. Owing to number of advantages dissociated with the quick onset of action and it by passes the liver. Sublingual tablets offer effective and easier way for management of Hypertension. The basic approach used in development of Sublingual tablet was the use of super disintegrants by direct compression method. Oral mucosal drug delivery is one of the promising method of systemic drug delivery which offers several advantages. The lite

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Mukul, Malpure* Aniket Gudur Rini Punathil Sanket Dharashivkar. "A Review on Sublingual Tablets: An Efficient Alternative for Drug Administration." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1408–18. https://doi.org/10.5281/zenodo.14882066.

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Oral mucosal drug delivery is a novel route for systemic drug delivery, which not only has many advantages but also has many potentials. Sublingual, meaning "under the tongue," is the method of drug administration in which the drug substance is placed under the tongue alone for rapid absorption through the vessels beneath the tongue. The sublingual route bypasses hepatic first-pass metabolic processes, which results in better bioavailability, faster onset of action, and greater patient compliance. If sublingual medications are used, the onset of action is faster than that expected for orally a

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Arena, A., E. Barbatano, E. Gammeri, M. Bruno, and G. Riva. "Specific Immunotheraphy of Allergic Diseases: A Three Years Perspective Observational Study." International Journal of Immunopathology and Pharmacology 16, no. 3 (2003): 277–82. http://dx.doi.org/10.1177/039463200301600314.

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In order evaluate the long-term benefit of Specific ImmunoTherapy (SIT), administered either subcutaneously or sublingually, in comparison with drug therapy, in terms of efficacy, tolerability and patients' adherence to the treatment, a three years perspective, observational study was carried out in a rather large number of allergic subjects. One hundred and ten patients of both sex (50F, 60M; age: 22.4 – 35.5 years) were admitted. Sixty of them were rhinitics, some with concomitant mild intermittent asthma or conjunctivitis; 43 had a persistent asthma, often with concomitant rhinitis. Seven h

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Stie, Mai Bay, Johan Ring Gätke, Ioannis S. Chronakis, Jette Jacobsen, and Hanne Mørck Nielsen. "Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin." International Journal of Molecular Sciences 23, no. 3 (2022): 1458. http://dx.doi.org/10.3390/ijms23031458.

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The sublingual mucosa is an attractive route for drug delivery, although challenged by a continuous flow of saliva that leads to a loss of drug by swallowing. It is of great benefit that drugs absorbed across the sublingual mucosa avoid exposure to the harsh environment of the gastro-intestinal lumen; this is especially beneficial for drugs of low physicochemical stability such as therapeutic peptides. In this study, a two-layered hybrid drug delivery system was developed for the sublingual delivery of the therapeutic peptide desmopressin. It consisted of peptide-loaded mucoadhesive electrospu

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14

Namrata, S. Revar* Samruddhi B. Sawant Sanjeevani D. Rupwate. "Sublingual Dosage Form." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 397–403. https://doi.org/10.5281/zenodo.8371537.

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Sublingual dosage forms have gained significant attention in the field of pharmaceuticals due to their unique route of administration and rapid onset of action. This dosage form involves placing medication under the tongue, where it dissolves and is absorbed directly into the bloodstream through the highly vascularized sublingual mucosa. This route offers several advantages, including avoiding first-pass metabolism in the liver, enhancing bioavailability, and providing a non-invasive and convenient option for patients who have difficulty swallowing or require fast drug action. In this abstract

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15

Ganapthy, Dhanraj, Padma Ariga, and Anand Selvaraj. "Sublingual drug dispensing prosthesis." Indian Journal of Dental Research 23, no. 3 (2012): 434. http://dx.doi.org/10.4103/0970-9290.102254.

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16

Maninder, Pal Singh* Ashita Pawaiya Gurpreet Kaur. "A Review on Sublingual Drug Delivery System for Better Bioavalibility." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1879–90. https://doi.org/10.5281/zenodo.15222571.

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Oral mucous membrane drug delivery is seen to offer a possible substitute for oral administration. When a quick onset of action is required and higher patient compliance is sought than with oral medications, the sublingual route can be helpful. The sublingual region of the oral cavity has a higher permeability than the buccal region, which is higher than the roof of the mouth region. By avoiding hepatic first-pass metabolic processes, the portion of the drug absorbed through the sublingual blood vessels has good bioavailability. For patients with dysphagia, elderly people, and children, sublin

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Tooba, Arif Rana, Qasim Maria, Kalam Alfia, and Parveen Saba. "Administration of Fast Dissolving Oral Thin Film Orlistat drug via sublingual route instead of oral route." International Journal of Innovative Science and Research Technology 7, no. 5 (2022): 1691–706. https://doi.org/10.5281/zenodo.6825008.

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Patients with obesity are given orlistat (120) mg capsules three times a day by oral route of administration, although oral method of administration does not produce good and accurate outcomes. Aim: To see if giving orlistat in tablet form as a sublingual medication delivery mechanism is useful in treating obesity in patients. Densign and Setting: This article is based on past research and does not include any experiments involving humans or animals undertaken by any of the authors. Method: We use Google Scholar, Medline, PubMed, Research Gate, and Science Direct to retrieve scientific databas

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Jha, Rani, Manoj Rungta, and Shailesh Kumar Jha. "Missed Abortion in a Tertiary Hospital of Eastern Nepal: Efficacy of Sublingual versus Vaginal Misoprostol." Journal of College of Medical Sciences-Nepal 17, no. 4 (2021): 347–51. http://dx.doi.org/10.3126/jcmsn.v17i4.41513.

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Introduction: Missed abortion is a nonviable intrauterine pregnancy in the presence of a closed cervix and little or no abdominal cramping. WHO recommends Misoprostol as a safe drug in the medical management of missed abortion. This study was conducted to study the efficacy of sublingual versus vaginal misoprostol in the medical management of missed abortion. Methods: A hospital based prospective study was carried out among 212 women with confirmed missed abortion who received 800 μg misoprostol either sublingually or vaginally for the medical management. All women were admitted to hospital fo

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19

He, Shaolong, and Huiling Mu. "Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery." Pharmaceutics 15, no. 2 (2023): 637. http://dx.doi.org/10.3390/pharmaceutics15020637.

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Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification in buccal/sublingual dosage forms has attracted increasing interest as a promising pharmaceutical strategy to enhance the oral mucosal absorption of drugs with pH-dependent solubility. Optimizing drug absorption at the oral mucosa using pHM modification is considered to be a compromise between drug solubility and drug lipophilicity (Log D)/permeation. To create a desired pHM around formulations during the dissolution process, a suitable amount of pH modifiers should be added in the formulations, and the app

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20

Mohd, Abdul Hadi. "FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF FELODIPINE FOR THE TREATMENT OF HYPERTENSION." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4781–90. https://doi.org/10.5281/zenodo.1091572.

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Sublingual administration of the drug means placement of the drug under the tongue and drug reaches directly in to the blood stream through the ventral surface of the tongue and floor of the mouth. The concept of formulating Sublingual tablets of Felodipine (antihypertensive drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two synthetic superdisintegrants (crospovidone and sodium starch glycollate) In the present work comparison between crospovidone and s

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Baker, Danial E. "Formulary Drug Review: Sufentanil Sublingual." Hospital Pharmacy 54, no. 4 (2019): 222–28. http://dx.doi.org/10.1177/0018578719851726.

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Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the nee

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22

Rottman, Steven J., and Baxter Larmon. "Nitroglycerine Lingual Aerosol in Prehospital Emergency Care,." Prehospital and Disaster Medicine 4, no. 1 (1989): 11–14. http://dx.doi.org/10.1017/s1049023x00038474.

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Nitroglycerine (NTG) commonly is used in the prehospital emergency care setting for the treatment of chest pain suggestive of myocardial ischemia or infarction or for cardiac unloading in patients with presumed pulmonary edema. The usual form of this drug is as a 400 mcg tablet administered sublingually. Recently, NTG has become available as an aerosolized form (NTGA) in a multiple dose, pressurized canister containing 200 metered doses of 400 meg of NTG each. In this form, the drug is purported to be absorbed rapidly from the surface of the tongue.In the field, we have noted that the sublingu

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Hilleman, Daniel E., and Umesh V. Banakar. "Issues in Contemporary Drug Delivery." Journal of Pharmacy Technology 8, no. 5 (1992): 203–11. http://dx.doi.org/10.1177/875512259200800509.

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Objective: To identify and discuss the clinical utility of new delivery systems and formulations of cardiac drugs. Data Sources: Studies describing or evaluating new drug delivery systems for cardiac drugs were identified through a MEDLINE literature search. Study Selection: All studies describing or evaluating new delivery systems for cardiac drugs were reviewed. Data Extraction: Data were abstracted and evaluated by each author independently. Data Synthesis: The most common oral sustained-release formulations include the wax-matrix system, the gastrointestinal therapeutic system (GITS), and

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Kumar, Y. Shravan, Deepthi B, and Mounika M. "Formulation and Evaluation of Salbutamol Sulphate Sublingual Films." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 5 (2017): 3836–43. http://dx.doi.org/10.37285/ijpsn.2017.10.5.4.

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Salbutamol is a short-acting, selective beta-2-adrenergic receptor agonist used in treatment of asthma and COPD. In the present work, sublingual films of Salbutamol sulphate were developed with a view to enhance the patient compliance and provide quick onset of action. Salbutamol has a bioavailability of 53 - 60%. The goal of the study was to formulate sublingual films of Salbutamol sulphate to achieve a better dissolution rate and further improving the bioavailability of the drug. Sublingual films prepared by solvent casting method using film forming polymers HPMC-E5, HPMC-E15 and Maltodextri

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T., S. Kanade A. Gupta* S. Mahajan G. N. Darwhekar. "Review on Sublingual Tablets – A Promising Formulation for Instant Action." Int. J. in Pharm. Sci. 1, no. 7 (2023): 250–60. https://doi.org/10.5281/zenodo.8156354.

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The current article is focused on ideal characteristics, patented technologies, significant features and formulating methods including the use of superdisintegrants, which achieve rapid onset of action, better patient compliance and increased bioavailability. Sublingual tablets dissolve instantaneously, releasing the drug, within a few seconds without the need of water and chewing. The objective behind this review was to summaries the benefits of sublingual formulation, mechanism of action, advantages of route of administration, factors affecting permeability of drug, various in vitro evaluati

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Salatin, Sara, Raziyeh Asadi, and Mitra Jelvehgari. "Development and characterization of sublingual films for enhanced bioavailability of selegiline hydrochloride." Therapeutic Delivery 12, no. 2 (2021): 159–74. http://dx.doi.org/10.4155/tde-2020-0118.

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Background: Low oral bioavailability of selegiline hydrochloride (SH) is primarily due to extensive first-pass metabolism and hence the need for an alternative pathway of administration. Materials & methods: Herein, we report the development of sublingual SH films. The films were formulated with varying polymer composition (F1-F6) and evaluated for physicochemical characteristics, in vitro drug release and ex vivo permeation studies. Results: The film F2 demonstrated satisfactory weight (10.60 mg), folding endurance (>200), drug content (11.44 mg/cm2), disintegration time (68 s), mucoad

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Salman, Sam, Daryl Bendel, Toong C. Lee, David Templeton, and Timothy M. E. Davis. "Pharmacokinetics of a Novel Sublingual Spray Formulation of the Antimalarial Drug Artemether in Healthy Adults." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3197–207. http://dx.doi.org/10.1128/aac.05013-14.

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ABSTRACTThe pharmacokinetics of sublingual artemether (ArTiMist) was investigated in two open-label studies. In study 1, 16 healthy males were randomized to each of four single-dose treatments administered in random order: (i) 15.0 mg of sublingual artemether (5 × 3.0 actuations), (ii) 30.0 mg of sublingual artemether (10 × 3.0 mg), (iii) 30.0 mg of sublingual artemether (5 × 6.0 mg), and (iv) 30.0 mg of artemether in tablet form. In study 2, 16 healthy males were randomized to eight 30.0-mg doses of sublingual artemether given over 5 days as either 10 3.0-mg or 5 6.0-mg actuations. Frequent b

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Sah, Somya, Ashutosh Badola, and Preeti Kothiyal. "Sublingual tablets: an overview." Indian Journal of Pharmaceutical and Biological Research 4, no. 2 (2016): 20–26. http://dx.doi.org/10.30750/ijpbr.4.2.3.

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Oral administration is one of the most convenient forms for the intake of drug due to ease of administration, painless, versatility, and paramount patient compliance. The demand of fast disintegrating tablets has been growing, during the last decades especially for geriatric and pediatric patients due to dysphasia. So the new drug delivery known as orally disintegrating tablets came to existence. As nowadays most of the people need effective relief within a short period of time so sublingual is the most suitable form of administration. These tablets disintegrate and dissolve rapidly in saliva

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Siji, C. Ann Rose Augusthy and Vipin K.V. "FORMULATION AND EVALUATION OF CARVEDILOL SUBLINGUAL TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1043–50. https://doi.org/10.5281/zenodo.1185156.

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Carvedilol is an oral antihypertensive agent. Due to its poor water solubility it posses problems of variable bioavailability and bioequivalence. In the present work an attempt was done to develop sublingual tablets of carvedilol using different superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate in different ratios. As carvedilol is a poor soluble drug the solubility was enhanced by solid dispersion method. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wett

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Staffieri, Paul, Kent Owusu, Maria Cardinale, and Amber Castle. "Ophthalmic atropine for sublingual use: A novel treatment for excessive respiratory secretions." Case Reports in Internal Medicine 3, no. 3 (2016): 82. http://dx.doi.org/10.5430/crim.v3n3p82.

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We describe a novel case of utilizing ophthalmic atropine suspension via sublingual route to control excessive secretions in a critically ill patient. In addition, a medication event related to a labeling and administration event is described where the patient received the drug via ophthalmic route. A 32-year-old Hispanic female presenting with NMDA-receptor antibody mediated encephalitis experienced a prolonged intensive care unit (ICU) stay secondary to hypercarbic respiratory failure complicated by excessive respiratory secretions. After one week on mechanical ventilation, the patient was s

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Fathei, Marzieh, Mitra Alami-milani, Sara Salatin, et al. "Fast Dissolving Sublingual Strips: A Novel Approach for the Delivery of Isosorbide Dinitrate." Pharmaceutical Sciences 25, no. 4 (2019): 311–18. http://dx.doi.org/10.15171/ps.2019.34.

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Background: Isosorbide dinitrate (ISDN) is used for treating the angina attacks. In addition, oral ISDN is available in immediate and sustained release formulations and the bioavailability of ISDN is about 20-25% when taken orally. Further, the ISDN films are developed for sublingual drug delivery by improving drug bioavailability. The present study aimed to design and evaluate the physicochemical properties of the film formulation for sublingual delivery of ISDN. Methods: In the present study, sublingual films were prepared by the solvent casting technique using the hydroxypropyl methylcellul

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Emeryk, Andrzej, Thibault Vallet, Ewelina Wawryk-Gawda, Arkadiusz Jędrzejewski, Frederic Durmont, and Fabrice Ruiz. "Acceptability of a Sublingual Drug Formulation for Respiratory Tract Infections in Children Aged 3 to 5 Years." Pharmaceutics 13, no. 2 (2021): 294. http://dx.doi.org/10.3390/pharmaceutics13020294.

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In pediatrics, acceptability has emerged as a key factor for compliance, and consequently for treatment safety and efficacy. Polyvalent mechanical bacterial lysate (PMBL) in 50-mg sublingual tablets is indicated in children and adults for the prophylaxis of recurrent respiratory tract infections. This medication may be prescribed in children over 3 years of age; the appropriateness of this sublingual formulation should thus be demonstrated amongst young children. Using a multivariate approach integrating the many aspects of acceptability, standardized observer reports were collected for medica

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Swetha, M., Bhargavi Ummalaneni, Ujwala Pawar, Thandu Manasa, and V. Keerthi. "An overview on sublingual drug delivery system." International Journal of Pharmacy and Pharmaceutical Science 7, no. 1 (2025): 125–29. https://doi.org/10.33545/26647222.2025.v7.i1b.160.

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Amruta, Pol*1 Rachana Sarawade2. "Development And Evaluation Of Sublingual Tablets Of Levodopa." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 125–40. https://doi.org/10.5281/zenodo.11109715.

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The objective of the development of this formulation was to develop a suitable drug delivery system that would bypass the hepatic metabolism and increase the bioavailability of Levodopa. Even though Levodopa exhibits low oral bioavailability it is the widely used drug for Parkinson’s disease treatment. By preparing the sublingual tablets that dissolve and disintegrate in the oral cavity, this method may overcome the limitations of low oral bioavailability and poor brain uptake of levodopa. Levodopa Sublingual tablets were prepared by direct compression method using different types of sup

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Alhamhoom, Yahya, Abhay Sharma, Shivakumar Hagalavadi Nanjappa, et al. "Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine." Pharmaceuticals 16, no. 11 (2023): 1589. http://dx.doi.org/10.3390/ph16111589.

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Nisoldipine (NIS) is a calcium channel blocker that exhibits poor bioavailability (~5%) due to low aqueous solubility and presystemic metabolism in the gut wall. In this context, the present work aimed to develop NIS solid dispersion (NISSD)-based sublingual films using solvent casting technique to improve the dissolution. Phase solubility studies indicated that Soluplus® was the most effective carrier for improving the aqueous solubility of NIS. NISSDs were initially developed using the solvent evaporation method. Fourier transform infrared spectrometric studies were found to display the char

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Singh, Harmanpreet, Pooja Jaiswal, Suksham Gupta, and Simerjit Singh. "FORMULATION OF RIZATRIPTAN BENZOATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION WITH DIFFERENT BIOADHESIVE POLYMER: IN VITRO AND EX VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 36. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21334.

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Objective: The current investigation deals with formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate (RTB) to produce its intended therapeutic effect for acute treatment of migraine. When the drug is given by sublingual route, it overcomes the first pass metabolism and quick entry of drug in systemic circulation is obtained. It would result in fast pharmacological response hence faster relief from migraine which is an important criterion in migraine therapy.Methods: In this study, RTB sublingual tablets were prepared using direct compression process usin

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C, Naveen, Kiran kumar Y, Venkateshwar Rao P, and T. Rama Rao. "Chemical Enhancers in Buccal and Sublingual Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 1 (2011): 1307–19. http://dx.doi.org/10.37285/ijpsn.2011.4.1.3.

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Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs with superior pharmacological efficacy, site specificity and devoid of toxic effects. However, the major problem for the oral delivery of these therapeutic agents is their extensive presystemic metabolism, instability in acidic environment resulting into inadequate and erratic oral absorption. Parenteral route of administration is the only established route that overcomes all these drawbacks associated with these orally less/inefficient drugs. But, these formulations are

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S., Sreelatha, Nethra H. S., Seema Nadagoudar, Vandana Ambastha, and Rajeshwari . "A comparative study of different route of administration of misoprostol in the management of third stage of labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 9 (2017): 3865. http://dx.doi.org/10.18203/2320-1770.ijrcog20174023.

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Background: Post partum haemorrhage is the most common cause of maternal morbidity and mortality. Misoprostol is a prostaglandin analogue, used for management of post partum haemorrhage. It can be used by various routes with minimal side effects. This study is done to compare the different routes of administration of Misoprostol for the third stage management and their side effects. Objectives of present study were to estimate the amount of blood loss, to assess the maternal side effects of drug, to know the haemoglobin deficit, to know the duration of third stage of labour.Methods: This was a

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Yoshizawa, Kunio, Akinori Moroi, Shuichi Kawashiri, and Koichiro Ueki. "A Case of Sublingual Ranula That Responded Successfully to Localized Injection Treatment with OK-432 after Healing from Drug Induced Hypersensitivity Syndrome." Case Reports in Dentistry 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6939568.

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A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS) is a rare but well-recognized serious adverse effect characterized by fever, skin rashes, generalized lymphadenopathy, hepatitis, and hepatosplenomegaly and oral stomatitis. This paper presents the first case of successfully treated sublingual ranula with localized injection of OK-432 after healing from drug induced hypersensitivity syndrome, which has previously been unreported in the literature

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Jadhav, Mr Mayur. "Development of Fast-Acting Sublingual Tablets of Levetiracetam: Formulation and Characterization." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 05 (2025): 1–9. https://doi.org/10.55041/ijsrem47514.

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ABSTRACT The objective of the present study was to formulate and evaluate Levetiracetam 500 mg sublingual tablets to achieve rapid disintegration and enhanced bioavailability through the sublingual route. Four formulations (F1–F4) were developed by varying the concentrations of microcrystalline cellulose, crospovidone, PVP K-30, and mannitol, with a fixed amount of Levetiracetam and citric acid. Microcrystalline cellulose and mannitol were selected as diluents to promote mouthfeel and mechanical strength, while crospovidone was incorporated as a superdisintegrant to ensure rapid disintegration

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Ivelisse Santiago, Darlene, and Jorge Duconge. "2198." Journal of Clinical and Translational Science 1, S1 (2017): 32. http://dx.doi.org/10.1017/cts.2017.119.

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OBJECTIVES/SPECIFIC AIMS: The objective of this study is the pharmacology of sublingual Buprenorphine in Hispanics/Latino men and women. Specifically we plan to: (1) Administer sublingual buprenorphine to Hispanic/Latino men and women volunteers, and measure the circulating amounts of the drug in the bloodstream as a function of time; that is, pharmacokinetics of buprenorphine. The goal of the proposed study is to evidence that there are gender and ethnic differences in the pharmacokinetics of sublingual buprenorphine between not only Hispanics/Latinos and non-Hispanics/Latinos (Caucasian), bu

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Verma, Aruna, Abhilasha Gupta, and Monika Kashyap. "Sublingual Misoprostol for labour augmentation." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 4 (2019): 1300. http://dx.doi.org/10.18203/2320-1770.ijrcog20191062.

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Background: Labour dystocia is associated with a number of adverse maternal and neonatal outcomes. Augmentation of labour is a commonly used intervention in cases of labour dystocia. Misoprostol is an inexpensive and stable prostaglandin E1analogue. Present study was done to see the effectiveness of sublingual misoprostol for labour augmentation and foeto-maternal outcome.Methods: Total 100 labouring women of term gestation were taken and divided in two groups: group A (study group) and group B (control group). In study group 25mcg sublingual misoprostol given 4 hourly till adequate uterine co

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Roshan, Ghatmale, and T. Pathan V. "AN OVERVIEW OF SUBLINGUAL ROUTES FOR DRUG DELIVERY & THEIR APPLICATION." INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND INNOVATIONS IN PHARMA SCIENCES 1, no. 2 (2023): 78–83. https://doi.org/10.5281/zenodo.8019357.

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Lopez-Vidal, Lucía, Alejandro J. Paredes, Santiago Daniel Palma, and Juan Pablo Real. "Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)." Pharmaceutics 15, no. 5 (2023): 1459. http://dx.doi.org/10.3390/pharmaceutics15051459.

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Domperidone (DOM) is a drug commonly used to treat nausea and vomiting, as well as gastrointestinal disorders. However, its low solubility and extensive metabolism pose significant administration challenges. In this study, we aimed to improve DOM solubility and avoid its metabolism by developing nanocrystals (NC) of DOM through a 3D printing technology—melting solidification printing process (MESO-PP)—to be delivered via a solid dosage form (SDF) that can be administered sublingually. We obtained DOM-NCs using the wet milling process and designed an ultra-rapid release ink (composed of PEG 150

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Isla, Sadia Nowshin, Sreebash Chandra Bhowmik, Marzia Alam, et al. "Formulation and Evaluation of Metformin Hydrochloride Sublingual Film." Bangladesh Pharmaceutical Journal 28, no. 2 (2025): 152–59. https://doi.org/10.3329/bpj.v28i2.83226.

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Metformin hydrochloride (HCl) fast-dissolving sublingual films were formulated to enhance bioavailability and minimize side effects through rapid onset of action and optimized drug-release and dissolution characteristics. Initially, the same formulation design with different ratios of metformin HCl (Drug), polymer A and plasticizer B was used to formulate nine batches of sublingual films utilizing solvent casting methods. The film formulations were evaluated based on morphological properties (color, clarity, flexibility and smoothness, trinocular microscopic image of film), physical properties

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De Jesús Valle, María José, Aranzazu Zarzuelo Castañeda, Cristina Maderuelo, et al. "Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa." Pharmaceutics 14, no. 7 (2022): 1497. http://dx.doi.org/10.3390/pharmaceutics14071497.

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A pharmaceutical vehicle based on lyophilized liposomes is proposed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. Liposomes made of egg phosphatidylcholine and cholesterol (7/3 molar ratio) were prepared and lyophilized in the presence of different additive mixtures with mucoadhesive and taste-masking properties. Palatability was assayed on healthy volunteers. The lyophilization cycle was optimized, and the lyophilized product was compressed to obtain round and capsule-shaped tables that were evaluated in healthy volunteers. Tablets were also

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Lee, M. C., and D. K. Menon. "Sublingual drug delivery during functional magnetic resonance imaging." Anaesthesia 60, no. 8 (2005): 821–22. http://dx.doi.org/10.1111/j.1365-2044.2005.04307.x.

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Debe, Manar Samir, Saeed Ahmad Khan, Iman Saad Ahmed, Zahid Hussain, Mohammad Nasir Uddin, and Mutasem Rawas-Qalaji. "Nasal versus sublingual routes for emergency drug administration." Journal of Pharmaceutical Sciences 114, no. 9 (2025): 103903. https://doi.org/10.1016/j.xphs.2025.103903.

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Nath, Jayati, Maneesha Jain, Rehana Najam, and Rina Sharma. "To compare the Effectiveness and Tolerability of Misoprostol as a Cervical Ripening Agent in the First Trimester Abortion through Sublingual and Vaginal Routes of Administration." Bangladesh Journal of Obstetrics & Gynaecology 27, no. 2 (2016): 63–66. http://dx.doi.org/10.3329/bjog.v27i2.29920.

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Objective: To compare the effectiveness and tolerability of misoprostol as a cervical ripening agent in first trimester abortion through sublingual and vaginal routes of administration.Material and Methods: This study was carried out in the department of Obst. & Gynae Teerthanker Mahaveer Medical College and Research Centre (TMMC&RC). A total of 120 patients were included in the study. They were divided in two groups Group A 60 patients sublingual Group B 60 patients vaginal The drug was administered 3-4 hours before suction and evacuation by sublingual and vaginal routes. Effi

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van Wijk, Roy Gerth. "Sublingual immunotherapy in children." Expert Opinion on Biological Therapy 8, no. 3 (2008): 291–98. http://dx.doi.org/10.1517/14712598.8.3.291.

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