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Journal articles on the topic 'Sublingual Misoprostol'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Jha, Rani, Manoj Rungta, and Shailesh Kumar Jha. "Missed Abortion in a Tertiary Hospital of Eastern Nepal: Efficacy of Sublingual versus Vaginal Misoprostol." Journal of College of Medical Sciences-Nepal 17, no. 4 (2021): 347–51. http://dx.doi.org/10.3126/jcmsn.v17i4.41513.

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Introduction: Missed abortion is a nonviable intrauterine pregnancy in the presence of a closed cervix and little or no abdominal cramping. WHO recommends Misoprostol as a safe drug in the medical management of missed abortion. This study was conducted to study the efficacy of sublingual versus vaginal misoprostol in the medical management of missed abortion. Methods: A hospital based prospective study was carried out among 212 women with confirmed missed abortion who received 800 μg misoprostol either sublingually or vaginally for the medical management. All women were admitted to hospital fo

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Tahir Saihood, Sumaya. "Role of Misoprostol in Induction of Labor: Sublingual versus Vaginal in Tikrit City." Tikrit Journal of Pharmaceutical Sciences 8, no. 2 (2023): 165–71. http://dx.doi.org/10.25130/tjphs.2012.8.2.3.165.171.

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A successful induction of labor leads to vaginal delivery of a healthy baby, in an acceptable time frame with minimum maternal discomfort or side effects. To compare the efficacy and safety of sublingual and per vaginal 25µg misoprostol for labor induction. Primary outcome measures were the number of cases delivering vaginally, Secondary requirement, the incidence of meconium-stained liquor, number of cesarean deliveries, the incidence of hyperstimulation/tachysystole, maternal adverse effects and neonatal outcomes. A prospective study was conducted in Tikrit Teaching Hospital. Indications wer

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Chavan, Shrikrushna Vasant, Niraj Nilkanth Mahajan, and Arundhati Gundu Tilve. "Randomized comparison of vaginal and sublingual misoprostol with mifepristone priming in termination of second trimester pregnancy." International Journal of Research in Medical Sciences 7, no. 10 (2019): 3869. http://dx.doi.org/10.18203/2320-6012.ijrms20194323.

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Background: Sublingual Misoprostol 200 ug 4 hrly is as effective or less effective than vaginal Misoprostol 200ug 4hrly with 200mg oral Mifepristone in termination of second trimester pregnancy.To compare effectiveness, side-effects, and patient satisfaction of sublingual vs vaginal misoprostol administration.Methods: It was prospective randomized open label study. 60 women 13-20 weeks of gestation with a valid legal indication for termination of pregnancy as per MTP act in INDIA were enrolled for study, randomly divided into Group A- Sublingual (n=30) group B-Vaginal (n=30). For group A, 200

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Qadir, Maimoona. "Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First-Trimester Missed Miscarriages." Journal of Gandhara Medical and Dental Science 12, no. 1 (2024): 11–14. https://doi.org/10.37762/jgmds.12-1.614.

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OBJECTIVES To evaluate the efficacy of sublingual versus vaginal misoprostol for the treatment of missed miscarriages in the first trimester of pregnancy. METHODOLOGY The gynecology and obstetrics department of Khyber Teaching Hospital in Peshawar conducted this Randomized Controlled Trial investigation from January 2021 to December 2023. Two groups of patients were formed, according to the FIGO procedure, based on whether misoprostol was given vaginally or orally. The dosages of 800 micrograms were administered vaginally to the first group and sublingually to the second group every three hour

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HUSSAIN, UZMA, FARZANA LATIF, and TEHSEEN AKHTER. "TERMINATION OF PREGNANCY." Professional Medical Journal 16, no. 02 (2009): 252–57. http://dx.doi.org/10.29309/tpmj/2009.16.02.2930.

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O b j e c t i v e : To compare the efficacy of vaginal misoprostal with that of sublingual misoprostol in 2n d trimester of pregnancyby comparing the induction-expulsion interval between two groups of patients induced with vaginal and sublingual misoprostol. S t u dyd e s i g n : Interventional, quasi experimental study. Settings: Obstetrics & Gynaecology Unit 1, Sir Ganga Ram Hospital, Lahore. Durationof s t u d y : Thirteen months from October 2006 to November 2007. S u b j e c t s a n d M e t h o d s : Sixty women at 12-26 weeks of gestation whichwere selected for termination of pregnan

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Siwatch, Sujata, and Vanita Jain. "Sublingual vs Vaginal Misoprostol for Labor Induction." Journal of Postgraduate Medicine, Education and Research 46, no. 3 (2012): 138–43. http://dx.doi.org/10.5005/jp-journals-10028-1031.

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ABSTRACT Background This study is a randomized controlled trial comparing the efficacy and safety of sublingual vs vaginal misoprostol for induction of labor. Materials and methods A total of 160 women admitted for induction of labor at the PGIMER, Chandigarh, India were randomized to receive 25 μg of vaginal or sublingual misoprostol for labor induction. The two groups were compared for mode of delivery, induction delivery interval, misoprostol dose required, uterine contraction abnormalities and neonatal outcomes. Results Majority of women in both groups delivered vaginally (91 and 89% in va

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Sara Hijaz, Noor-e-Mubeen, Rakhshinda Inam Khan, Rubab Ahmad, Sara Jamil Khan, and Ayesha Nasir. "Comparison of the Effectiveness of Sub Lingual Vs Vaginal Misoprostol in Termination of First Trimester Missed Abortion." Annals of Punjab Medical College 18, no. 4 (2024): 324–30. https://doi.org/10.29054/apmc/2024.1697.

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Background: The incidence of spontaneous miscarriages increases with age. In the first trimester, the leading cause of spontaneous abortion is embryonic abnormalities, responsible for 80-90% of all miscarriages. Miscarriage affects 10-20% of clinically recognized pregnancies. Objective: To compare the effectiveness of sublingual versus vaginal routes of misoprostol in termination of first trimester missed abortion. Study Design: Quasi-experimental trial. Settings: Department of Obstetrics and Gynecology, Khyber Teaching Hospital, Peshawar Pakistan. Duration: March, 2022 to March, 2023. Methods

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Zainab, Ayazahmed Kharodiya, Ayaz Ismail Lunat, and Ayazahmed Kharodia Shamimah. "Study of Sublingual Misoprostol and Oral Misoprostol for Induction of Labor at Term- an Open Label Randomized Prospective Study." International Journal of Current Pharmaceutical Review and Research 15, no. 09 (2023): 190–96. https://doi.org/10.5281/zenodo.11653613.

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AbstractBackground: Misoprostol, an oral prostaglandin compound, is being increasingly used for induction of labor byvaginal, oral and sublingual route, though unlicensed for this use. This study was undertaken to compare theefficacy of sublingual misoprostol to oral misoprostol in induction of labor at term.Materials and Methods: This prospective study was done from 1st December 2020 to 15th September 2021. Studyincluded total 160 patients admitted to Tata Main Hospital for induction of labor at 37-42 weeks of gestation,who were randomized into two groups of 80 women each as Group A (Oral mis

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Batool, Amber, Saima Muhammad Ali, Iffat Irshad, and Riffat Iqbal. "Manual Vacuum Aspiration During Early Pregnancy Failure: A Comparison of Sublingual and Vaginal Misoprostol for Pain Management." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 565–67. http://dx.doi.org/10.53350/pjmhs22168565.

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Objective: compare sublingual and vaginal misoprostol in terms of mean pain score during manual vacuum aspiration in cases of early pregnancy failure. Methodology: A total of 100 women with missed abortions, blighted ovaries, and 9 gm/dl haemoglobin were investigated at Wateem Medical and Dental College, Rawat, Rawalpindi. Complete medical history, physical, and obstetrical exam. Same doctor used ultrasound to determine pregnancy. Grouping of patients was done randomly (based on table of random numbers). Group (A)(n=50) was evaluated two hours after sublingual misoprostol. Group (B) (n=50) got

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Siwatch, Sujata, and Goter Doke. "Sublingual vs Oral Misoprostol for Labor Induction." Journal of Postgraduate Medicine, Education and Research 48, no. 1 (2014): 33–36. http://dx.doi.org/10.5005/jp-journals-10028-1097.

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ABSTRACT Background This study compares the eficacy and safety of sublingual vs oral misoprostol for induction of labor. Materials and methods 160 women admitted for induction of labor at the Postgraduate Institute of Medical Education and Research, Chandigarh were randomized to receive 25 µg misoprostol orally 3 hourly or 25 µg sublingual misoprostol 4 hourly for labor induction. Outcome The two groups were compared for number of women not delivered in 24 hours, misoprostol dose required, induction delivery interval, incidence of uterine contraction abnormalities, mode of delivery, side effec

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Khan, Umber Imtiaz, Bushra Iftikhar, Syeda Suraya Jabeen, Nuzhat Aisha Akram, Bushra Subktageen, and Arwa Fatima. "Comparison of the Sublingual and Vaginal Misoprostol for Medical Termination of Pregnancy in Cases of First and Second Trimester Abortion: A Quasi Experimental Study." Pakistan Armed Forces Medical Journal 72, no. 2 (2022): 414–18. http://dx.doi.org/10.51253/pafmj.v72i2.7241.

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Objective: To compare the success rate of sublingual and vaginal Misoprostol for medical termination of pregnancy in the first and second trimesters. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Obstetrics and Gynecology, Combined Military Hospital, Malir Pakistan, from May 2019 to Nov 2019. Methodology: Two hundred patients in their first or second trimester of pregnancy with different indications for termination of pregnancy were included through consecutive sampling. Spousal consent was also taken along with wife consent. Patients were

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Geels, Yvette Pernella, Marije Carlijn Gordinou de Gouberville, Lucia Visser, and Hendrikus Arnoldus van Asten. "Comparing vaginal and sublingual administration of misoprostol for labour induction in women with intra-uterine fetal death." Tropical Doctor 40, no. 2 (2010): 77–80. http://dx.doi.org/10.1258/td.2009.090339.

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The objective of this study was to compare complications and effectiveness of induction after vaginal and sublingual administration of misoprostol for labor induction in women with intra-uterine fetal death (IUFD). In a district hospital in Ghana, 23 women with IUFD who underwent labor induction with sublingual misoprostol were compared with a control group of 21 women who received vaginal misoprostol. In the vaginal group 28.6% had one or more complications compared to 21.7% in the sublingual group. In the sublingual group three inductions did not lead to delivery within 48 hours (13%), compa

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Nimbark, Neha, Paramtap M. Joshi та Mittal I. Joshi. "A randomised comparative study of induction of labour with sublingual misoprostol 50 μg and oral misoprostol 50 μg in term patients". International Journal of Basic & Clinical Pharmacology 12, № 2 (2023): 211–15. http://dx.doi.org/10.18203/2319-2003.ijbcp20230389.

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Background: Current study was conducted to compare the efficacy of tab Misoprostol 50 microgram by oral and sublingual routes for induction of labour. Methods: A randomised comparative study of induction of labour in 200 cases of pregnant women at term and were divided into two groups of 100 each for 50 µg Misoprostol for oral and sublingual route repeated 4 hourly either by sublingual or oral route until an adequate contraction pattern set in (establishment of 3 uterine contractions in a period of 10 minutes) or once the cervical dilatation reaches 4 cm, maximum up to 6 doses. The patients we

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Acharya, Indira, Sumana Thapa, and Pushpa Chaudhary. "Efficacy and Safety of Sublingual versus Vaginal Misoprostol for Pre-induction Cervical Ripening among Primigravida." Medical Journal of Shree Birendra Hospital 17, no. 1 (2018): 18–24. http://dx.doi.org/10.3126/mjsbh.v17i1.17882.

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Introduction: Induction of labor is an intervention intended to artificially initiate uterine contractions resulting in progressive effacement and dilatation of the cervix. This is a common intervention during pregnancy in both industrialized and non-industrialized countries.Misoprostol is the commonly used induction agent. The objective of this study was to compare the efficacy of sublingual route of misoprostol with that of vaginal for pre-induction cervical ripening at term among Primigravida.Methods: This study was a hospital based cross sectional comparative study, conducted at a tertiary

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Janjua, Mahham, and Maria Imran. "A COMPARISON OF THE EFFECTIVENESS OF SUBLINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN INFUSION IN REDUCING BLOOD LOSS IN FIRST TWO HOURS AT CAESAREAN SECTION." Pakistan Postgraduate Medical Journal 31, no. 03 (2021): 132–37. http://dx.doi.org/10.51642/ppmj.v31i03.350.

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OBJECTIVE The objective of the study was to compare the effectiveness of sublingual misoprostol in reducing intraoperative and postoperative blood loss with that of intravenous (IV) oxytocin infusion in the first two hours at cesarean delivery. STUDY DESIGN Randomized controlled trial PLACE AND DURATION OF STUDY The study was conducted in Lady Aitchison Hospital, Lahore unit IV-King Edward Medical University, and the duration of the study was one year. MATERIALS and METHODS Eighty-two women with term singleton pregnancy undergone elective cesarean sect

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S., Sreelatha, Nethra H. S., Seema Nadagoudar, Vandana Ambastha, and Rajeshwari . "A comparative study of different route of administration of misoprostol in the management of third stage of labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 9 (2017): 3865. http://dx.doi.org/10.18203/2320-1770.ijrcog20174023.

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Background: Post partum haemorrhage is the most common cause of maternal morbidity and mortality. Misoprostol is a prostaglandin analogue, used for management of post partum haemorrhage. It can be used by various routes with minimal side effects. This study is done to compare the different routes of administration of Misoprostol for the third stage management and their side effects. Objectives of present study were to estimate the amount of blood loss, to assess the maternal side effects of drug, to know the haemoglobin deficit, to know the duration of third stage of labour.Methods: This was a

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Jadai swamy, Madhu, and U. S. Hangaraga. "Comparison of sublingual versus vaginal routes of misoprostol in induction of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 7 (2017): 3062. http://dx.doi.org/10.18203/2320-1770.ijrcog20172935.

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Background: Induction of labor can be defined as an intervention intended to artificially initiate uterine contractions resulting in progressive effacement and dilatation of cervix. Present study was under taken to compare the efficacy of sublingual versus vaginal routes of administration of misoprostol for induction of labor.Methods: Prospective observational study conducted from January 2010 to January 2011 in the Department of Obstetrics and Gynecology at Karnataka Institute of Medical Sciences, Hubli, Karnataka, India. The patients were selected from either antenatal ward or emergency admi

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Acharya, Indira, Sumana Thapa, and Pushpa Chaudhary. "Efficacy and Safety of Sublingual versus Vaginal Misoprostol for Pre-induction Cervical Ripening among Primigravida." Medical Journal of Shree Birendra Hospital 17, no. 2 (2018): 18. http://dx.doi.org/10.3126/mjsbh.v17i2.17882.

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<p><strong>Introduction: </strong>Induction of labor is an intervention intended to artificially initiate uterine contractions resulting in progressive effacement and dilatation of the cervix. This is a common intervention during pregnancy in both industrialized and non-industrialized countries.Misoprostol is the commonly used induction agent. The objective of this study was to compare the efficacy of sublingual route of misoprostol with that of vaginal for pre-induction cervical ripening at term among Primigravida.</p><p><strong>Methods:</strong> This

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Shrestha, Deepak, Shreyashi Aryal, and Binita Sharma. "Safety, Efficacy and Acceptability of Early First Trimester Abortion using Oral Mifepristone and Sublingual Misoprostol." Journal of Nepal Health Research Council 16, no. 3 (2018): 269–73. http://dx.doi.org/10.33314/jnhrc.v16i3.1378.

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Background:With the legalization of medical abortion in Nepal, mifepristone-misoprostol combination via different routes has been widely used for early abortion. This study aims to evaluate the efficacy and acceptability of 200 milligrams mifepristone orally followed by 800 micrograms sublingual misoprostol in outpatient setting.Methods: It was an open-label prospective study conducted in outpatient department of a tertiary hospital over a period of 13 months. Clients upto nine weeks of pregnancy were enrolled. 200 milligrams of mifepristone orally followed by 800 micrograms of misoprostol sub

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Akare, Monika D., and Purvi K. Patel. "A comparison of sublingual with vaginal administration of misoprostol for induction of labor at term." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 4 (2017): 1398. http://dx.doi.org/10.18203/2320-1770.ijrcog20171398.

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Background: To compare the efficacy and safety of sublingual route of misoprostol with vaginal route of administration.Methods: This study was conducted at Department of Obstetrics and Gynecology, Medical College, Baroda, Gujarat, India. 50 cases each with a singleton term pregnancy and a live fetus requiring induction of labor were allocated to sublingual and vaginal administration of misoprostol. Outcome measures related to labor and maternal and fetal side effects were compared between the 2 groups and evaluated using Chi square test and relative risk (RR) with 95% confidence intervals (CI)

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Faiqa Saleem Baig, Bushra Bano, and Raheela Danish. "THE EFFICACY AND SAFETY OF SUBLINGUAL VS ORAL MISOPROSTOL FOR INDUCTION OF LABOUR IN LOW-RISK PREGNANCIES AT TERM." Pakistan Postgraduate Medical Journal 36, no. 01 (2025): 28–32. https://doi.org/10.51642/ppmj.v36i01.712.

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Objective: Various methods of induction of labor are being used by doctors to achieve vaginal birth. Globally, 25% of births involve induction of labor. Misoprostol has gained attention recently in settings with limited resources due to its affordability, easy administration, and stability at room temperature. The study aims to evaluate the safety and effectiveness of sublingual misoprostol with oral misoprostol for the induction of labor in low-risk pregnancies at term. Method: A randomized controlled, prospective study was carried out in the Obstetrics and Gynecology Unit III, Jinnah Hospita

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Mazhar, Tayaba, and Naila Bukhari. "EFFICACY AND SAFETY OF SUBLINGUAL MISOPROSTOL FOR CERVICAL PRIMING BEFORE MINOR GYNECOLOGICAL PROCEDURES." Journal of Medical Sciences 32, no. 4 (2024): 303–8. https://doi.org/10.52764/jms.24.32.4.2.

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OBJECTIVE To assess the efficacy and safety of 400 micrograms of sublingual misoprostol in comparison to the same dose of vaginal misoprostol for cervical priming before minor gynecological procedures. MATERIALS AND METHODS The Randomized Controlled Trial was conducted in Khyber Teaching Hospital from 1st April 2021 to 31st Oct 2022. The sample size was 212, and a convenient random sampling technique was used. Fifty percent of the patients were given sublingual misoprostol 400 micrograms 2 hours before surgery (group A), while the rest were given 400 micrograms vaginal misoprostol 4 hours befo

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Abdelrazek, Eslam, Abdullah K. Ahmed, and Al-Refaai A. Marai. "SUBLINGUAL MISOPROSTOL VS SUBLINGUAL MISOPROSTOL WITH VAGINAL ESTRADIOL FOR LABOR INDUCTION." Al-Azhar Medical Journal 50, no. 1 (2021): 243–52. http://dx.doi.org/10.21608/amj.2021.139717.

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Arif, Nadia, Bushra Zafar, Raja Qaseem Ahmed, and Farrukh Shehzad. "Comparison of Feasibility, Efficacy and Patient Acceptability of Manual Vacuum Aspiration Vs Sublingual Misoprostol in Early Pregnancy Loss." Pakistan Armed Forces Medical Journal 72, no. 3 (2022): 854–57. http://dx.doi.org/10.51253/pafmj.v72i3.4144.

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Objective: To compare feasibility, efficacy and patient acceptability of manual vacuum aspiration with sublingual Misoprostol in early pregnancy loss. Study Design: Comparative prospective study. Place and Duration of Study: Gynecology and Obstetrics Department, Combined Military Hospital Okara Pakistan, from Aug 2019 to Apr 2020. Methodology: 200 Patients with early pregnancy loss (missed, incomplete abortion) at gestational age 6 to 12 weeks were randomly allocated to Manual vacuum aspiration (group A) and oral Misoprostol (group B) by lottery methods. Manual vacuum aspirat

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Ahmed, A. Elgaml. "Intrauterine Device Insertion in Women with Pervious Cesarean Section Using Vaginal Versus Sublingual Misoprostol: A Randomized Clinical Trial." MAR Gynecology & Urology 5, no. 7 (2023): 12. https://doi.org/10.5281/zenodo.10243286.

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<i><strong>Background</strong>: The cesarean section (CS) makes the cervix stenosed and narrow, so that most of women who have previously had a CS always found it difficult and painful to insert an intrauterine device (IUD). Priming with misoprostol before hysteroscopy and dilatation and curettage in premenopausal women resulted in an increased cervical dilatation and lower rate of cervical laceration because of misoprostol utility for cervical ripening before this procedure.</i><i><strong>Objective</strong>: The aim of the study is to compare the effect of vaginal versus sublingual misoprosto

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Verma, Aruna, Abhilasha Gupta, and Monika Kashyap. "Sublingual Misoprostol for labour augmentation." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 4 (2019): 1300. http://dx.doi.org/10.18203/2320-1770.ijrcog20191062.

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Background: Labour dystocia is associated with a number of adverse maternal and neonatal outcomes. Augmentation of labour is a commonly used intervention in cases of labour dystocia. Misoprostol is an inexpensive and stable prostaglandin E1analogue. Present study was done to see the effectiveness of sublingual misoprostol for labour augmentation and foeto-maternal outcome.Methods: Total 100 labouring women of term gestation were taken and divided in two groups: group A (study group) and group B (control group). In study group 25mcg sublingual misoprostol given 4 hourly till adequate uterine co

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Alva, José, Hugo Alva, and Juan Canales. "Eficacia del misoprostol vía sublingual comparado con vía oral en el tercer periodo del parto." Revista Peruana de Ginecología y Obstetricia 46, no. 1 (2015): 53–58. http://dx.doi.org/10.31403/rpgo.v46i1387.

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OBJETIVO: Determinar si el misoprostol administrado por vía sublingual es más eficaz que administrado vía oral en el tercer período del parto. DISEÑO: Se realizó un estudio experimental. Prospectivo, de corte transversal, comparativo (dos grupos pareados). LUGAR: Servicio de Obstetricia del Hospital Regional Docente de Trujillo, durante los meses de junio a diciembre de 1991. MATERIAL: La muestra estuvo conformada por 2 grupos de 39 gestantes cada uno, elegidas en forma secuencial, en el que uno de ellos recibió 200 μg de misoprostol vía sublingual (triturado) y el otro vía oral. Los indicador

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Ghimire, Sailaja, Deepanjali Sharma, Samjhana Dhakal, and Gehanath Baral. "Comparison between Sublingual and Vaginal Misoprostol for Induction of Labour in Primigravida." Nepal Journal of Obstetrics and Gynaecology 13, no. 3 (2018): 51–55. http://dx.doi.org/10.3126/njog.v13i3.23509.

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Aims: To compare the outcome and side effects of administration of sublingual misoprostol with vaginal misoprostol for induction of labour and cervical ripening. Methods: It was a hospital based comparative study which was carried out in 120 patients in each group of sublingual and vaginal route of misoprostol induction from August 2016 to February 2017 at Paropakar Maternity and Women’s Hospital, Thapathali, Kathmandu. Patients with Bishops score <6 were subjected for Misoprostol 25 μg (for maximum 2 doses) 6 hours apart. Results were analyzed using SPSS 21 taking p-value <0.05 as

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Galidevara, Chandana, Latha Chaturvedula, and Syed Habeebullah. "Comparison of oral, vaginal and sublingual misoprostol for induction of labour in premature rupture of membranes after 34 weeks of gestation: a randomized controlled trial." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 4 (2018): 1340. http://dx.doi.org/10.18203/2320-1770.ijrcog20180958.

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Background: Purpose of this study was to evaluate the efficacy and safety of different routes of administration of misoprostol - 50µg oral, 25µg vaginal and 50µg sublingual for induction of labour in women with premature rupture of membranes after 34 weeks of gestation.Methods: Women admitted to labour ward with premature rupture of membranes (PROM) after 34 weeks of gestation and requiring induction of labour were randomized into three groups. A total of 246 women participated in the study and were assigned to three groups to receive either 50µg oral misoprostol (n=80) or 25µg vaginal misopro

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Patel, Raxita, Ami Patel, Debshree a, Vaishali Panchal, and Harsh Patel. "COMPARATIVE STUDY OF SUBLINGUAL AND VAGINAL MISOPROSTOL TABLET IN MISSED ABORTION." International Journal of Advanced Research 9, no. 06 (2021): 623–29. http://dx.doi.org/10.21474/ijar01/13054.

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Introduction: Management of missed abortion is matter of concern for obstetrician in terms of its methods and complications. Objectives: To compare efficacy, side effects and complications of sublingual and vaginal misoprostol tablet in missed abortion case of less than 20 weeks of gestation. Methods: Total 300 cases were taken, and out of those 300 cases, group A (150cases) included cases who were given sublingual misoprostol tablet, and group B (150 cases) included cases who were given vaginally misoprostol tablet. Observation: Mean gestational age is 7.9 and 8 weeks in Group A and Group B r

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Maria Imran, Rabia Wajid, and Maham Janjua. "Sublingual Misoprostol Vs Intravenous Methyl ergotamine in reducing blood loss after delivery – A randomized controlled trial." Pakistan Postgraduate Medical Journal 30, no. 01 (2020): 22–26. http://dx.doi.org/10.51642/ppmj.v30i01.248.

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BACKGROUND Postpartum hemorrhage is a very important cause of maternal mortality worldwide. According to WHO, 20 million of morbidities and 33 % of maternal mortality can be attributed to PPH worldwide. WHO states that misoprostol can also be used to prevent PPH, due to its beneficial effects in low income settings. OBJECTIVE The objective of the study was to compare the effectiveness of sublingual misoprostol in reducing blood loss with that of methyl ergotamine in first two hours after delivery. METHODOLOGY It was a randomized controlled, single center, double blind trial of subl

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Gupta, Ruchi, Krishna Priya Banerjee, and Reena Pant. "A comparative study of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 2 (2019): 498. http://dx.doi.org/10.18203/2320-1770.ijrcog20190274.

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Background: The objective of this study is to assess the effectualness and safety of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy.Methods: This institution based contingent study was conducted on 220 women requesting for mid-trimester termination of pregnancy between 12-20 weeks with legal indication as per Govt. MTP act. After excluding the women as per exclusion criteria, they were randomly allocated into two groups (Group A Sublingual, Group B Oral), the women received 200 mg oral mifepristone followed by sublingual or oral mis

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Safi, Saeeda, Asia Habib, Momy Gul, Ghazala Iftikhar, and Shazia Anwar. "Effect of Intraveous Tranexamic Acid and Sublingual Misoprostol on Reducing Post Cesarean Section Bleeding." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 3400–3402. http://dx.doi.org/10.53350/pjmhs2115103400.

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Background and Aim: Cesarean section rates are rising around the globe and are considered as the major surgical procedure conducted on females. Cesarean-related hemorrhage contributes to increasing mortality rates around the world. Due to the rise in cesarean rate and its associated complications, post-cesarean severe bleeding without proper management is a major concern. Therefore, the present study aimed to assess the intravenous tranexamic acid (TA) and sublingual misoprostol effect on reducing post-cesarean section bleeding. Materials and Methods: This cross-sectional study was conducted o

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Ewuoso, Dr Bernard O. "Sublingual Misoprostol in Active Management of the third Stage: Maternal Outcome." Journal of Medical Science and clinical Research 12, no. 11 (2024): 01–10. https://doi.org/10.18535/jmscr/v12i11.01.

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Background: The use of uterotonic agents in active management of the third stage of labor has been shown to reduce postpartum hemorrhage. Although intramuscular oxytocin remains the uterotonic of choice, others such as intravenous oxytocin, ergometrine, carboprost, and misoprostol can be used. Sublingual misoprostol has been shown to have the greatest bioavailability, achieving the highest plasma concentration in the shortest time when compared to other routes at equal dose. Objective: To evaluate whether the addition of sublingual misoprostol to intramuscular oxytocin in active management of

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Sinha, Divya, Sourabh Shrivastava, and Swati Shrivastava. "A comparative study of oral, sublingual and vaginal route of misoprostol as cervical ripening agent before surgical method of termination of first-trimester pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 4 (2017): 1295. http://dx.doi.org/10.18203/2320-1770.ijrcog20171034.

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Background: Cervical ripening is a critical step for surgical method of termination of first trimester of pregnancy. Misoprostol, PGE1 analogue have promising role as cervical ripening agent. The present study aimed to compare the efficacy and side effects of oral, sublingual and vaginal misoprostol at dosage of 400mcg for cervical priming before surgical method of termination in first-trimester pregnancy.Methods: It was a prospective hospital based randamosied study. Total 150 patients at 6-12 weeks gestation requesting for medical termination of pregnancy were divided equally in to 3 groups.

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Poonam, Singh, Verma Shikha, and Kumari Usha. "Investigation into the Outcomes of using Sublingual Misoprostol for Terminating Early Pregnancy." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1466–69. https://doi.org/10.5281/zenodo.12759375.

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<strong>Background and Objectives:  </strong>Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early1930. Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy for termination of Pregnancy its success. And failure is varied the dose and route are not well established. Studies evaluating different regimens, including combination mifepristone and misoprostol and alone regimens, show varying results related to safety, efficacy and other outcome. To study the efficacy of sub

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Angarita Peñaranda, William, Benjamín Rodríguez Yances, and Orlando Borre Arrieta. "Misoprostol sublingual en el tercer período del parto. Estudio clínico doble ciego, con asignación aleatoria, controlado con placebo en el Hospital de Maternidad Rafael Calvo de Cartagena." Revista Colombiana de Obstetricia y Ginecología 54, no. 2 (2003): 81–86. http://dx.doi.org/10.18597/rcog.615.

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Determinar la seguridad y eficacia del misoprostol sublingual en el manejo activo del alumbramiento.Materiales y métodosLa presente investigación es un estudio a doble ciego, prospectivo, con asignación aleatoria y controlado contra placebo. Se administró una dosis de 100 µg de misoprostol sublingual o placebo durante el tercer período de parto inmediatamente después del pinzamiento del cordón. Se cuantificó estrictamente el sangrado en un recipiente calibrado, la duración del alumbramiento, los signos vitales y los efectos colaterales.ResultadosEl sangrado promedio en el grupo de misoprostol

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Akbar, Rashida, Basma ., Rozina Mujeeb Sahito, Raishem Ali, Sonia Gul Qureshi, and Saira Parveen Memon. "Role of Manual Vacuum Aspiration Versus Sublingual Misoprotol in First Trimester Miscarriage in a Tertiary Care Hospital PMC, Nawabshah." Pakistan Journal of Medical and Health Sciences 16, no. 3 (2022): 754–57. http://dx.doi.org/10.53350/pjmhs22163754.

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Objective: To compare the efficacy of manual vacuum aspiration versus sublingual misoprostol in first trimester miscarriage at people's medical college hospital Nawabshah. Study Design: Randomized Controlled Trial. Settings: Department of Gynaecology and Obstetrics, Peoples Medical University & Hospital Nawabshah. Duration of Study: 7th April 2021 to 6th October 2021. Materials & Methods: A total of 100women with first trimester incomplete abortion, 18 to 45 years of age were included. Patients having allergy to misoprostol or other prostaglandins, contraindication to prostaglandin the

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Dewangan, Sonal, Mithlesh Dewangan, Noor Afshan Sabzposh, Imam Bano, and Syed Manazir Ali. "Efficacy of 25 mcg sublingual versus vaginal misoprostol for induction of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 12 (2017): 5341. http://dx.doi.org/10.18203/2320-1770.ijrcog20175239.

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Background: Currently, to decrease the incidence of contractility disturbances and neonatal complications, 25 mcg of vaginal misoprostol is recommended for induction of labor. American College of Obstetrics and Gynecology suggested 25 mcg every 4-6 hourly by vaginal route. But till date, there is no consensus either for route or dosage. The present study was to compare the efficacy and suitability of low dose (25 μg) sublingual misoprostol for induction of labor in term pregnancy as compared with the same dose given vaginally.Methods: This was a hospital based unblinded randomized prospective

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Thakur, Srishti, and Charu Pratap. "Comparison between sublingual 600 and 800 microgram misoprostol after mifepristone for MTP up to 9 weeks gestation." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 12 (2018): 4996. http://dx.doi.org/10.18203/2320-1770.ijrcog20184955.

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Background: The objective of the present study was to compare the efficacy between sublingual 600 and 800 microgram Misoprostol after administration of Mifepristone up to 9 weeks gestation, to compare the incidence of side effects between the two doses. To compare the acceptability between the two doses.Methods: This study is a single-center, randomized study. The study is conducted at Fortis Escorts Hospital and Research Centre, Faridabad, during period of May 2014 to June 2015. 160 Pregnant women with singleton pregnancy up to 9 weeks gestation, visiting OPD of Obstetrics and Gynaecology, wh

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Alshoura, Asmaa A. A. A., Ahmed M. El-khiat, Shereen B. Elbohoty, and Karam A. Shaheen. "Comparative study between misoprostol and lidocaine before intrauterine contraceptive device insertion." Tanta Medical Journal 52, no. 2 (2024): 138–41. http://dx.doi.org/10.4103/tmj.tmj_69_22.

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Background Intrauterine contraceptive device (IUCD) is a safe, extremely effective and long-acting reversible contraceptive method. Misoprostol has definite to be a very pliable and adequate drug because its composition as a tablet that is stable and may be delivered orally, rectally or vaginally, and through the sublingual route. Lidocaine is a common local anesthetic and antiarrhythmic drug. Aims The objective of the present study was to compare between sublingual administration of misoprostol and lidocaine spray prior to IUCD insertion. Patients and methods This randomized controlled clinic

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Yadav, Shikha, and Nootan Chandwaskar. "Comparative study of misoprostol sublingually and dinoprostone gel intracervically for cervical ripening and induction of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 8 (2017): 3624. http://dx.doi.org/10.18203/2320-1770.ijrcog20173497.

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Background: Both Prostaglandin E1 and E2 analog are being used for cervical ripening. The aims of study was to compare the efficacy and safety profile of sublingual misoprostol (PGE2) and intracervical dinoprostone (PGE1) for cervical ripening and induction of labor.Methods: One hundred women with single live fetus and with gestational age of more than 37 weeks admitted for induction of labor were recruited for the study. Patients were randomized to receive either 25μg of misoprostol sublingually or dinaprostone gel (0.5mg) intracervically.Results: There was shorter induction to active phase,

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Zahra, Azeem Iffat Naheed Sara Ejaz Khadija waheed* Amna khanum Asim Khan. "COMPARISON OF THE MEAN BLOOD LOSS WITH SUBLINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN IN LOW-RISK FEMALES UNDERGOING NORMAL VAGINAL DELIVERY." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4043–47. https://doi.org/10.5281/zenodo.1045319.

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Background: Oxytocin and Misoprostol are considered to be the two most effective drugs in preventing PPH. But contradiction in literature was observed. So to confirm whether misoprostol is more effective than oxytocin for prevention of PPH, we conducted this study. Objective: To compare the mean blood loss with sublingual misoprostol versus intravenous oxytocin in low-risk females undergoing normal vaginal delivery Material & Methods: This randomized control trial was conducted at Unit IV, Department of Obstetrics and Gynecology, Lady Aitchison Hospital, Lahore. The duration of the study w

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Bhute, Sindhu, Deepti Shrivastava, Deepali Khamsara та Poonam Pandey. "Sublingual 400 μg Misoprostol vs Intravenous 0.2 mg Methylergometrine for Active Management of Third Stage of Labor". Journal of South Asian Federation of Obstetrics and Gynaecology 5, № 1 (2013): 15–18. http://dx.doi.org/10.5005/jp-journals-10006-1211.

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ABSTRACT Objectives To compare the efficacy and side effects of sublingual 400 μg misoprostol with 0.2 mg intravenous methylergometrine in active management of third stage of labor. Materials and methods In a prospective, randomized comparative study conduted in Department of Obstetrics and Gynecology, AVBRH, Wardha, 200 women at full-term gestation, without any high risk factors were studied in two groups of 100 each, for safety and efficacy of 400 μg sublingual misoprostol in comparison to 0.2 mg intravenous methylergometrine at the delivery of anterior shoulder from December 2010 to Novembe

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Angarita Peñaranda, William, Orlando Borré Arrieta, and Benjamín Rodríguez Yances. "Manejo activo del alumbramiento con Misoprostol sublingual: un estudio clínico controlado en el Hospital de Maternidad Rafael Calvo de Cartagena." Revista Colombiana de Obstetricia y Ginecología 53, no. 1 (2002): 87–91. http://dx.doi.org/10.18597/rcog.655.

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OBJETIVOS: El objetivo del presente estudio es establecer la seguridad, eficacia y costos del Misoprostol sublingual, en el manejo activo del tercer periodo del parto.MATERIAL Y MÉTODOS: Se hace un estudio prospectivo, randomizado, controlado, donde se distribuyen 75 pacientes en tres grupos de 25 pacientes: A. Misoprostol sublingual, B. Oxitocina endovenosa, C. Metil-ergonovina postalumbramiento. Se cuantificó el sangrado durante la primera hora posparto y tiempo de alumbramiento. Se valoró el costo de los insumos utilizados en cada grupo, el comportamiento de los signos vitales antes y despu

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Sandoval Paredes, José, Vanesa Fuentes, and Kerine Urrutia. "Misoprostol sublingual comparado con oxitocina intramuscular en la prevención de la hemorragia posparto." Revista Peruana de Ginecología y Obstetricia 50, no. 4 (2015): 212–16. http://dx.doi.org/10.31403/rpgo.v50i419.

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OBJETIVO: Determinar si existe diferencia en la eficacia y tolerancia del misoprostol por vía sublingual y oxitocina por vía intramuscular en la prevención de la hemorragia posparto. DISEÑO : Ensayo clínico aleatorizado realizado en el Hospital "Sergio E. Benales" de Lima, durante el período de enero a octubre de 2003. MATERIAL Y MÉTODOS: La muestra estuvo conformada por 136 parturientas divididas en dos grupos: al grupo 1, de 68 pacientes, se le administró 2OOµg de misoprostol por vía sublingual y al grupo II, de 68 pacientes, se le inyectó 10 UI de oxitocina por vía intramuscular, inmediatam

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Punita, Kumari, and Kumar Khetan Rajeev. "Comparing Sublingual and Vaginal Misoprostol for Cervical Preparation before Surgical Abortion in the First-Trimester." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1755–58. https://doi.org/10.5281/zenodo.11087199.

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<strong>Background:</strong> Synthetic prostaglandin E1 analogue misoprostol is commonly used in obstetrics and gynaecology for a number of purposes, including as cervical ripening prior to surgical abortions, medical abortion, and miscarriage treatment. Comparative study have been conducted on the misoprostol delivery route, specifically sublingual and vaginal, in order to assess patient satisfaction, safety, and effectiveness prior to first-trimester surgical abortion. <strong>Methods:</strong> A total of 160 women seeking surgical abortion in the first trimester in whom medic

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Saroha, Indu, Sita Thakur, Ajay Sood, Kamal Singh, Monica Karpa, and Swarnima Singh. "Comparative study of sublingual versus vaginal misoprostol for induction of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 2 (2020): 748. http://dx.doi.org/10.18203/2320-1770.ijrcog20200371.

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Background: Induction of labor done, when the benefits to either mother or fetus outweighs those of continuing pregnancy. Pharmacological methods used for induction includes oxytocin, prostaglandin (E1, E2) and mifepristone. However the ideal dose, route and frequency of administration of misoprostol are still under investigation. Hence we plan to do a comparative study between sublingual and vaginal misoprostol for inducing labor.Methods: A prospective randomized interventional study was conducted on seventy pregnant women who met the inclusion criteria. They were explained about the study on

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Shah, SR*, and H. Vhora. "Comparison of Induction of Labour with Mifepristone and Misoprostol at Term V/S. Induction with Misoprostol Alone." World Journal of Health and Medicine 2, no. 2 (2024): 1–6. https://doi.org/10.5281/zenodo.11075838.

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<strong>Abstract</strong> This study was carried out in Dr. M.K. Shah Medical college and SMS Multi-speciality Hospital, Tertiary care medical centre, catering to Lower middle class and middle-class community. <strong>Objective:</strong> To study the Efficacy and outcome of Oral Mifepristone and sublingual misoprostol <em>vs</em> sublingual misoprostol only for Induction of labour in Term Pregnancy. <strong>Methodology:</strong> Prospective study has been carried out in the Department of Obstetrics and Gynaecology, Dr. M.K Shah medical college and Research Centre, SMS multi-speciality hospital

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López Guevara, Ronald Edgardo. "Hipertermia posterior al uso de misoprostol sublingual en el manejo de atonía uterina." ALERTA Revista Científica del Instituto Nacional de Salud 3, no. 1 (2020): 9–12. http://dx.doi.org/10.5377/alerta.v3i1.8959.

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    La hiperpirexia secundaria al uso de misoprostol por la vía sublingual ya ha sido reportada en la literatura; en algunos casos requiere manejo en unidades de cuidados intensivos. Se presenta el caso de una paciente con hemorragia post parto por atonía uterina, quien fue tratada con misoprostol sublingual de 800 microgramos, posteriormente la paciente presentó hiperpirexia, como parte de la evolución clínica y el manejo recibido. La paciente tuvo una buena evolución clínica.   

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