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Dissertations / Theses on the topic 'Substance P Physiological effects'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Uzubalis, Ranate Ingrid. "A study of the metabolism, pharmacological properties and disposition of substance P /." Title page, table of contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phu99.pdf.

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2

Wong, Kenneth C. "Neuropeptide vascular reactivity in psoriasis." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27706.

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The skin is richly innervated with neuropeptide containing sensory nerve fibres which are involved in cutaneous inflammatory responses and augmentation of inflammation in the axonal reflex. Substance P (SP) and calcitonin generelated peptide (CGRP) are two of the most abundant neuropeptides in the skin. Neuropeptides have been postulated to play a role in the pathogenesis of psoriasis. Evidence to suggest this include: elevated levels of neuropeptides in psoriatic lesions; exacerbation of the disease with stress; improvement of psoriatic lesions with topical capsaicin, which is known to

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3

Svensson, Erik. "Modulatory effects and interactions of substance P, dopamine, and 5-HT in a neuronal network /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-524-7/.

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4

Halliday, Dale Andrew. "The effects of tachykinins and their metabolites or articular cartilage chondrocyte and synviocyte function /." Title page, contents and introduction only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh1878.pdf.

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5

Barragan, Adrian Alberto. "ASSESSMENT OF PHYSIOLOGICAL AND BEHAVIORAL RESPONSES IN DAIRY COWS TREATED WITH ASPIRIN FOLLOWING PARTURITION AND IN POSTPARTUM COWS DIAGNOSED WITH METRITIS." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500033085971928.

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6

Vilisaar, Janek. "The induction and effects of Substance P and its receptor in human immune cells and neurons : potential relevance in multiple sclerosis." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12663/.

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INTRODUCTION: Substance P (SP) has well-established roles in neurogenic inflammation and pain transmission, however recently, a number of SP immunomodulatory effects have been shown. In this thesis SP and its neurokinin-1-receptor (NK1R) role in autoimmune inflammation was investigated with an applicability to multiple sclerosis (MS). In the four experimental chapters the role of SP and its receptor was studied in human immune cells and neurons with a focus on the relationship with Th17 and Th1 pathways as the main pro-inflammatory arms in autoimmune pathology. AIMS: To quantify the effects of

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7

Locatelli, V. "DEXMEDETOMIDINE VS. XYLAZINE: EFFECTS ON BEHAVIOUR AND PLASMA CONCENTRATIONS OF CORTISOL AND SUBSTANCE P IN CALVES UNDERGOING TRUE AND SHAM DISBUDDING." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171965.

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Summary Disbudding is a routine painful procedures carried out on cattle to facilitate management (Gottardo et al. 2011, Duffield 2008, Laine et al. 2007, Stafford et al. 2005 e 2003, Marshall, 1977; Vowles, 1976). To measure the pain-induced distress caused by dehorning or disbudding plasma concentration of cortisol have been used more frequently than any other parameter (Boandl et al., 1989; Taschke and Folsch, 1993; Wohlt et al., 1994; Cooper et al., 1995; Morisse et al., 1995; Petrie et al., 1996; Sylvester et al., 1998; McMeekan et al., 1997, 1998; Graf and Senn, 1999; Grondahl-Nielsen

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8

Backman, Ludvig. "Neuropeptide and catecholamine effects on tenocytes in tendinosis development : studies on two model systems with focus on proliferation and apoptosis." Doctoral thesis, Umeå universitet, Anatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70193.

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Background: Achilles tendinopathy is a common clinical syndrome of chronic Achilles tendon pain combined with thickening of the tendon and impaired tendon function. Tendinopathy is often, but not always, induced by mechanical overload, and is frequently accompanied by abnormalities at the tissue level, such as hypercellularity and angiogenesis, in which case the condition is called tendinosis. In tendinosis, there are no signs of intratendinous inflammation, but occasionally increased apoptosis is observed. Tendinosis is often hard to treat and its pathogenesis is still not clear. Recently, a

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9

Nichols, Nicole L. "The Effects of Chronic Hypoxia and Substance P on the Chemosensitive Response of Individual Nucleus Tractus Solitarius (NTS) Neurons from Adult Rats." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1215465852.

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10

Song, Yafeng. "Cross transfer effects after unilateral muscle overuse : an experimental animal study about alterations in the morphology and the tachykinin system of muscles." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71242.

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Unilateral exercise can produce certain contralateral strength effects. Deleterious events can be cross-transferred as well, as illustrated by a strict symmetry in some chronic inflammatory diseases. To date, knowledge on the effects of marked overuse of skeletal muscles is limited, and there is largely no information if unilateral overuse affects the contralateral muscles. In view of this, the present study was undertaken to test the hypothesis that unilateral muscle overuse causes alterations in tissue structure and the tachykinin system, with a focus on substance P (SP), not only in the exe

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11

Hallberg, Mathias. "Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5745.

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12

Afrah, Abdullahi Warsame. "Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-185-3.

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13

Cheung, Chung-yan. "Effects of endocrine manipulation on the peptide levels and the gene expression of [beta]-endorphin, met-enkephalin, somatostatin, substance P and cholecystokinin in the rat hypothalamus and pituitary." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31220575.

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14

Cheung, Chung-yan. "Effects of endocrine manipulation on the peptide levels and the gene expression of b-endorphin, met-enkephalin, somatostatin, substance P and cholecystokinin in the rat hypothalamus and pituitary /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21038272.

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15

Zerabruk, MA. "Repair of sub-lethal damage following single and split-dose irradiation using 60co-gamma and p(66)Be neutrons." Thesis, Cape Peninsula University of Technology, 2005. http://hdl.handle.net/20.500.11838/1504.

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Thesis (MTech Biomedical Technology)--Cape Peninsula University of Cape Town, 2005<br>In clinical radiotherapy, experiments are performed to determine optimal conditions of the radiation prior to radiotherapy. These experiments focus on the relative biological effectivness(RBE) determination and are predominantly applied in high linear energy transfer (LET) radiations i.e. fast neutrons, as the RBE values for such radiations vary greatly. In general, the RBE of a certain radiation relative to a given reference radiation flCo gamma) varies widely with the energy, dose, dose rate, frac

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16

Kumarasinghe, Isuru Ransiri. "DESIGN, SYNTHESIS, NMR CONFORMATIONAL ANALYSIS AND DOCKING ANALYSIS OF NOVEL MULTIFUNCTIONAL MOLECULES FOR PAIN." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193738.

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Currently, opioids are extensively used in clinical practices in order to treat pain in patients. However, prolonged administration of opioids are not feasible due to the development of side effects especially tolerance, constipation, addiction and dependence. Our drug design is mainly aimed to reduce opioid induce side effects such as development of tolerance. The first strategy examined involves design and synthesis of peptide based single molecules that have a mu agonist and delta agonist pharmacophore in combination with a COX2 inhibitory pharmacophore. A new molecule, 3-17 having good del

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17

Uzubalis, Ranate Ingrid. "A study of the metabolism, pharmacological properties and disposition of substance P / Renate Ingrid Uzubalis." Thesis, 1995. http://hdl.handle.net/2440/21596.

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Bibliography: leaves 180-199.<br>xvii, 199, [68] leaves, [1] leaf of plates : ill. ; 30 cm.<br>Primary aim was to determine whether levels of the endogenous peptide substance P (SP) would parallel and reflect the reported increased levels of the trophic agent nerve growth factor which is associated with the development of sympathetic hyperinnervation (and ultimately hypertension) in the genetic animal model for hypertension, the spontaneously hypertensive rat.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1995

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18

Verplaetse, Terril Lee. "Effects of Prazosin Treatment on Ethanol- and Sucrose-Seeking and Intake in P Rats." Thesis, 2012. http://hdl.handle.net/1805/2970.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Background: Previous studies show that prazosin, an α1-adrenergic receptor antagonist, decreases alcohol drinking in animal models of alcohol use and dependence and in alcohol-dependent men. These studies extended previous findings by using a paradigm that allows for separate assessment of prazosin on motivation to seek versus consume ethanol or sucrose in selectively bred rats given acute or chronic prazosin treatment. Methods: Alcohol-preferring P rats were trained to complete an operant response that resulted in access to eithe

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19

Toalston, Jamie E. "Peri-adolescent Alcohol Consumption Enhances the Reinforcing and Stimulatory Properties of Ethanol within the Adult Mesolimbic Dopamine System in Alcohol Preferring P Rats." Thesis, 2012. http://hdl.handle.net/1805/2893.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Research in the alcohol preferring (P) rat has indicated that peri-adolescent alcohol (EtOH) consumption enhances the acquisition of oral operant EtOH self-administration, inhibits the extinction of responding for EtOH, augments EtOH-seeking behaviors, and increases relative reward value of EtOH during adulthood. Experiment 1 was conducted to determine if these adult effects of peri-adolescent EtOH intake could be observed using an Intracranial Self-Administration (ICSA) model. It was hypothesized that an increased sensitivity to the

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20

Tang, Fu-In, and 唐褔瑩. "Effects of Substance P and GDNF on Nigrostriatal Dopamine System." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/20089145804598447484.

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21

Donkin, James J. "The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats." 2006. http://hdl.handle.net/2440/37854.

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Traumatic brain injury (TBI) today remains a major health and social problem for both developed and developing countries. It is the leading cause of death and disability under the age of 40, and despite the significance of this public health problem, no effective therapy exists. While a number of factors have been shown to be associated with the development of irreversible tissue injury after TBI, the formation of oedema and opening of the blood brain barrier (BBB) have been shown to be of major significance to outcome. Oedema formation in the brain, when left uncontrolled, results in increase

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22

Ruby, Carl E. "Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells." Thesis, 2001. http://hdl.handle.net/1957/32558.

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In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of cells essential for the initiation and maintenance of adaptive immune responses, and represent a potential target of TCDD toxicity. Thus, the studies presented here address the a

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23

"The protective effects of Ganoderma extracts from the endocrine disruption of p,p'-DDE on breast cancer cell model." 2009. http://library.cuhk.edu.hk/record=b5896912.

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Qin, Jing.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves 162-218).<br>Abstract also in Chinese.<br>Acknowledgment --- p.i<br>Abstract --- p.ii<br>摘要 --- p.iv<br>Table of Content --- p.vi<br>List of Figures --- p.x<br>List of Tables --- p.xv<br>Abbreviations --- p.xvii<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Ganoderma spp --- p.1<br>Chapter 1.1.1 --- Introduction of Ganoderma spp --- p.1<br>Chapter 1.1.2 --- Bioactivities of Ganoderma spp --- p.3<br>Chapter 1.1.3 --- Endocrine system and breast canc

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24

Shembe, Zamakhosi Thina. "The effects of whoonga on the learning of affected youth in Kwa-Dabeka township." Diss., 2013. http://hdl.handle.net/10500/13827.

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Whoonga is a relatively new addition into the drug market. The need for this study was prompted by the devastating effects this new arrival has had in the lives of young people addicted to it. The purpose of this study was to investigate the effects of whoonga on the learning of affected youth in Kwa-Dabeka Township. This study adopted a qualitative method and employed a phenomenological approach to explore the experiences of participants with regard to whoonga use and their learning. Data was collected through purposive sampling. Interviews were conducted, using semi-structured and unstructur

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25

Han, Xu. "Identification and mechanistic investigation of clinically important myopathic drug-drug interactions." Thesis, 2014. http://hdl.handle.net/1805/5275.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Drug-drug interactions (DDIs) refer to situations where one drug affects the pharmacokinetics or pharmacodynamics of another. DDIs represent a major cause of morbidity and mortality. A common adverse drug reaction (ADR) that can result from, or be exacerbated by DDIs is drug-induced myopathy. Identifying DDIs and understanding their underlying mechanisms is key to the prevention of undesirable effects of DDIs and to efforts to optimize therapeutic outcomes. This dissertation is dedicated to identification of clinically important myop

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