Relevant bibliographies by topics / Substituent position

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Substituent position'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Substituent position"

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Exner, Otto, and Miloš Buděšínský. "Correlation of substituent – inducted chemical shifts of aromatic protons: Substituted benzonitriles and methyl benzoates." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2234–50. http://dx.doi.org/10.1135/cccc19912234.

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Proton NMR spectra in deuteriochloroform are reported for 53 meta- and para-substituted benzonitriles and 61 methyl benzoates. The substituent-induced chemical shifts (SCS) were correlated with dual substituent parameters (DSP), with 13C SCS of the adjoining carbon, and with the other 1H SCS using the principal component analysis (PCA). They are controlled by different factors in each position to the variable substituent. In the position 4 the long-range polar effects, as expressed by DSP, are decisive, the conjugative component being more important. Remarkable is also very close correlation o
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Matsumoto, Shoji, Makoto Takamori, and Motohiro Akazome. "Bathochromic Shift of Fluorescence Peak in Dipyrrolo[1,2-a:2′,1′-c]quinoxaline by Introducing Each of Electron-Donating and Electron-Withdrawing Substituent." Molecules 28, no. 7 (2023): 2896. http://dx.doi.org/10.3390/molecules28072896.

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Development of organic fluorophore is an important theme. Especially, the fluorophores with longer fluorescence peaks are useful to biological probes. One of the methods to change the fluorescence peak is the introduction of substituents. However, opposing characteristics of the substituents lead to different changes in the fluorescence peaks. Furthermore, the introduction of the substituent also affects their electric properties. Thus, if the materials were developed with the substituent effect on the optical and electric properties separately, it will be useful to design the functional mater
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Pytela, Oldřich. "Chemometric Analysis of Substituent Effects. I. Substituent Effects on the Dissociation of Monosubstituted Benzoic Acids." Collection of Czechoslovak Chemical Communications 59, no. 1 (1994): 159–74. http://dx.doi.org/10.1135/cccc19940159.

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Forty-six representative sets of data relating to the dissociation of monosubstituted benzoic acids in various solvents were extracted from the literature. The set of substituents included 25 common substituents in the meta position and the same number of substituents in the para position. Hydrogen served as the reference standard. The sets were subjected to regression analysis using conventional empirical models. The Hammett model was found to be valid within the limits of experimental error. The Taft model with the σR0, σR+ and σR- parameters is the best model to account for the substituent
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Harsanyi, MC, RK Norris, G. Sze, and PK Witting. "Substituent-Dependent Nitration of 9-Substituted 9,10-Dihydro-9,10-ethanoanthracenes." Australian Journal of Chemistry 48, no. 12 (1995): 1949. http://dx.doi.org/10.1071/ch9951949.

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Mononitration of 9-substituted ethanoanthracenes, bearing Me, But, F, Br, I, OMe , NO2, CN, CHO or CO2Me substituents at the bridgehead carbon, was found to occur exclusively at the β-positions of the aromatic ring. The mononitro products were isolated, identified by 1H n.m.r. spectroscopy, and their relative proportions were estimated by quantitative g.l.c . and/or by 1H n.m.r. spectroscopy. For all the above substrates the proportion of nitration at the β-position meta to the bridgehead carbon bearing the substituent [to give compounds of the general form (4)] was greater than the proportion
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Zhou, Yi-Fan, Wen-Yan Chang, Jing-Zhe Chen, et al. "Substituent-mediated quantum interference toward a giant single-molecule conductance variation." Nanotechnology 33, no. 9 (2021): 095201. http://dx.doi.org/10.1088/1361-6528/ac3b84.

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Abstract Quantum interference (QI) in single molecular junctions shows a promising perspective for realizing conceptual nanoelectronics. However, controlling and modulating the QI remains a big challenge. Herein, two-type substituents at different positions of meta-linked benzene, namely electron-donating methoxy (–OMe) and electron-withdrawing nitryl (–NO2), are designed and synthesized to investigate the substituent effects on QI. The calculated transmission coefficients T(E) indicates that –OMe and –NO2 could remove the antiresonance and destructive quantum interference (DQI)-induced transm
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Janowska, Sara, Joanna Stefańska, Dmytro Khylyuk, and Monika Wujec. "The Importance of Substituent Position for Antibacterial Activity in the Group of Thiosemicarbazide Derivatives." Molecules 29, no. 6 (2024): 1333. http://dx.doi.org/10.3390/molecules29061333.

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The search for new antibacterial compounds is still a huge challenge for scientists. Each new chemotherapy drug is not 100% effective when introduced into treatment. Bacteria quickly become resistant to known structures. One promising group of new compounds is thiosemicarbazides. In the presented work, we looked for the relationship between structure and antibacterial activity within the group of thiosemicarbazide derivatives. This is a continuation of our previous work. Here, we decided to check to what extent the position of the 3-methoxyphenyl substituent affects potency. We obtained new st
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Yang, Shuibo, Bin Sun, Zhongping Ou та ін. "β-Nitro-substituted free-base, iron(III) and manganese(III) tetraarylporphyrins: synthesis, electrochemistry and effect of the NO2 substituent on spectra and redox potentials in non-aqueous media". Journal of Porphyrins and Phthalocyanines 17, № 08n09 (2013): 857–69. http://dx.doi.org/10.1142/s1088424613500612.

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Two free-base and four metal derivatives of substituted tetraarylporphyrins containing a nitro-substituent on the β-pyrrole position of the macrocycle were synthesized and characterized by UV-vis, FTIR, 1 H NMR and mass spectrometry as well as electrochemistry and spectroelectrochemistry in non-aqueous media. The porphyrins are represented as ( NO 2 TmPP ) M and ( NO 2 TdmPP ) M , where M = 2 H , Fe III Cl or Mn III Cl , m is a CH 3 group on the para-position of the four meso-phenyl rings of the tetraphenylporphyrin (TPP) and dm represents two OCH 3 substituents on the meta-positions of each p
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Millheim, Alexandra Cruz, Enric Ponzano, and Albert Moyano. "Substituent Effects in the Photophysical and Electrochemical Properties of Meso-Tetraphenylporphyrin Derivatives." Molecules 29, no. 15 (2024): 3689. http://dx.doi.org/10.3390/molecules29153689.

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Porphyrins were identified some years ago as a promising, easily accessible, and tunable class of organic photoredox catalysts, but a systematic study on the effect of the electronic nature and of the position of the substituents on both the ground-state and the excited-state redox potentials of these compounds is still lacking. We prepared a set of known functionalized porphyrin derivatives containing different substituents either in one of the meso positions or at a β-pyrrole carbon, and we determined their ground- and (singlet) excited-state redox potentials. We found that while the estimat
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Simeonova, Kristina B., Ana I. Koleva, Nevena I. Petkova-Yankova, et al. "Elucidating the Mechanism of Coumarin Homodimerization Using 3-Acetylcoumarin Derivatives." Molecules 30, no. 3 (2025): 651. https://doi.org/10.3390/molecules30030651.

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The current study is a continuation of our previous investigations into the radical homodimeric reaction mechanism of 3-acetylcoumarin. In the current study, the effects of different substituents on the coumarin ring of 3-acetylcoumarin are investigated both experimentally and theoretically. Several 3-acetylcoumarin derivatives (substituted at C-6, C-7, and C-8) were tested in the optimized reaction conditions under ultrasound irradiation, and biscoumarin species were isolated and characterized. The elucidation of the substituent’s effect was further investigated by means of DFT calculations (
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Yano, Masafumi, Mai Sasaoka, Kohei Tamada, et al. "Substituent Control of Near-Infrared Absorption of Triphenylamine Radical Cation." Colorants 1, no. 3 (2022): 354–62. http://dx.doi.org/10.3390/colorants1030021.

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Five triphenyltriphenylamines with various substituents were investigated as precursors for near-infrared absorbing materials. Cyclic voltammetry (CV) studies showed that they all give stable radical cations in solution. The radical cations obtained by one-electron chemical oxidation of these compounds show strong absorption in the near-infrared region, and the position of the absorption is strongly influenced by the substituent. DFT (density functional theory) calculations suggest that the introduction of stronger electron-donating substituents would result in a smaller HOMO–SOMO energy gap a
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Dissertations / Theses on the topic "Substituent position"

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Yigitsoy, Basak. "Benzyl Functionalized Benzotriazole Containing Conjugated Polymers: Effect Of Substituent Position On Electrochromic Properties And Synthesis Of Crown Ether Functionalized Electrochromic Polymers." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613309/index.pdf.

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A new class of &pi<br>-conjugated monomers was synthesized with combination of electron donating and electron-withdrawing heterocyclics to understand the effects of structural differences on electrochemical and optoelectronic properties of the resulting polymers. Electron deficient benzotriazole, substititued with benzyl from two available sites, coupled with stannylated electron donating groups, ethylenedioxythiophene (EDOT) and thiophene (Th), to yield four different monomers<br>1-benzyl-4,7-di(thiophen-2-yl))-2H-benzo[d][1,2,3] triazole (BBTA), 2-benzyl-4,7-di(thiophen-2-yl))-2H-benzo[d][1,
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HURVOIS, JEAN-PIERRE. "Comportement electrochimique de 1,4-dihydropyridines substituees en position -4 par un groupement nitrophenyle." Rennes 1, 1992. http://www.theses.fr/1992REN10145.

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De nombreuses structures heterocycliques peuvent etre preparees par reduction electrochimique des 4-(o-nitrophenyl)-1,4-dihydropyridines ou des pyridines correspondantes. Dans le cas de la nifedipine, possedant deux groupements ester en positions -3 et -5 (ou de son derive n-methyle), la conformation de la molecule ne permet pas de reaction intramoleculaire du groupement ester avec les fonctions obtenues par reduction du groupement nitre. Cependant, les differents composes de reduction evoluent par suite de la reactivite particuliere du cycle dihydropyridine: des quinoleines sont obtenues par
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Munos, Marie-Hélène. "Synthese d'heterocycles azotes substitues en position deux : acces aux formes chirales et etudes antiparasitaires." Paris 11, 1997. http://www.theses.fr/1997PA114801.

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Mas, Jean-Manuel. "Synthèse énantiosélective d'hexadiène-1,5 ols-3 tertiaires substitués en position 5 et 6, étude de leur transposition d'oxy-cope." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599503n.

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CHAPTAL-GRADOZ, NATHALIE. "Regio et stereoselectivite de reactions de diels-alder entre des dienes portant un substituant allylique chiral en position deux et divers dienophiles. Applications." Paris 11, 1993. http://www.theses.fr/1993PA112310.

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L'etude de la regio et de la diastereoselectivite de la cycloaddition entre des dienes substitues en position 2 par un substituant allylique chiral et divers dienophiles a constitue l'essentiel de ce travail. Si la regioselectivite des reactions thermiques ou realisees dans un milieu concentre en perchlorate de lithium n'est que moyenne en faveur du produit para disubstitue, celle-ci devient totale dans la reaction catalysee par un acide de lewis. La diastereoselectivite faciale augmente, quant a elle, avec l'encombrement sterique du groupe r porte par le diene et est inversee selon que l'on u
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NGADI, LEON. "Synthese de mono et bis-acridinones-9 et thio-9 acridinones substituees en position 1 : analyse conformationnelle et etude de proprietes antimicrobiennes de molecules temoins." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX22970.

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Boudou, Valérie. "Synthèse et propriétés biologiques de Bêta-pentofurano-nucléosides de l'adénine d'énantiomérie non naturelle L : influence des substituants et des configurations en position(s) 2' et/ou 3'." Montpellier 2, 1997. http://www.theses.fr/1997MON20185.

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Afin de parvenir a de nouveaux composes antiviraux, plus actifs et moins toxiques que ceux actuellement utilises en clinique humaine, nous avons axe notre travail vers la synthese et l'etude d'analogues nucleosidiques de l'adenine, d'anomerie et d'enantiomerie non naturelle l. Le premier chapitre de cette these resume, a partir d'etudes bibliographiques, les proprietes biologiques de certains -l-nucleosides. Le second chapitre porte sur la synthese stereospecifique des quatre -l-pentofuranonucleosides de l'adenine, de leurs deux homologues 2'-desoxygenes et de la l-adenosine 5'-triphosphate. L
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CHARREAU, PHILIPPE. "Etude de quelques reactions fondees sur le deplacement du groupe benzenesulfonyle par des carbenoides halogenes et d'autres reactifs organometalliques. Application a la preparation d'olefines fonctionnalisees et d'heterocycles substitues en position 2." Paris 6, 1991. http://www.theses.fr/1991PA066064.

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Chapitre 1: la premiere preparation du diiodomethylsodium ainsi que sa stabilite thermique sont decrites. L'etude de la reactivite de ce carbenoide et de l'analogue lithie vis-a-vis d'electrophiles conduit a de nouvelles methodes de preparation de gem-diiodoalcanes. Chapitre 2: la reaction a basse temperature de differents carbanions sulfonyles avec des carbenoides tri-, di- et mono-halogenes est decrite. Elle conduit a des olefines 1,1-dihalogenees et a des halogenures vinyliques, des sulfures vinyliques et des vinylsilanes avec de bons rendements et une bonne stereoselectivite en faveur de l
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Yu, Yi-Chun, and 游逸群. "Study on the Mesophases and Electro-optical Properties of Chiral Liquid Crystals Derived from Chloromethyl Substituent Positioned at Asymmetric Carbon." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/57808742702996795191.

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碩士<br>大同大學<br>化學工程學系(所)<br>96<br>There are many factors affect the properties of ferroelectric chiral Smectic C phase such as chiral group, core structure, linking group, terminal chain length and optical purity. The purpose of this research is looking for a better understanding the relationship between molecular structures and mesomorphic properties. Thus, new chiral precursor, (S)-1-alkyloxy-3-chloro-2-propanols containing chlomethyl chiral group were designed and synthesized by the reaction of (S)-epichlorohydrin with alcohols under the acid condition. Consequently, six homologous series of
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Book chapters on the topic "Substituent position"

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Tanaka, Hideo, Yoshihisa Tokumaru, Ken-ichi Fukui, Sigeru Torii, Christian Amatore, and Anny Jutand. "Modification of Cephalosporins Bearing Substituents at C(3’)Position via Electrogenerated Radical-Cation of Sulfide." In Novel Trends in Electroorganic Synthesis. Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-65924-2_20.

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Burk, Robert M., David F. Woodward, Achim H. P. Krauss, et al. "Ocular Hypotensive Activity of Prostaglandin F2α (PGF2α) Analogs with Neutral Substituents at Position 1 is Predicted by the Isolated Cat Iris Sphincter Smooth Muscle Preparation but not Ca+ Signalling in Swiss 3T3 Cells." In Advances in Experimental Medicine and Biology. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0193-0_50.

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Matsumoto, M. "Friedel–Crafts Acylation of 1,4-Benzodioxins Bearing an Electron-Withdrawing Substituent at the 2-Position." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00023.

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H. Parsania, Parsotam, Jignesh P. Patel, and Pooja P. Adroja. "Synthesis, Characterization, and Pathogenic Activities of Bisphenol-C Derivatives." In Pharmaceutical Science. IntechOpen, 2024. https://doi.org/10.5772/intechopen.113043.

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We have focused on syntheses of several 1,1\'-bis(4-hydroxyphenyl)cyclohexane(Bisphenol-C) derivatives, their characterization, and pathogenic activities. The structures are supported by FTIR, 1H NMR, 13C NMR, and MS techniques. The crystal structure is determined by XRD. 1,1’-Bis(3-methyl-4-hydroxyphenyl)cyclohexane crystallizes into a mono-clinic crystal lattice having unit cell dimensions: a = 15.023(2) Å, b = 9.924(2) Å, and c = 11.620(2)Å, 1, 1’-bis(3-methyl-4-benzoyloxyphenyl)cyclohexane crystallizes into a tetragonal crystal lattice with unit cell dimensions: a = b = 13.3792(9)Å, and c
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Palekar, Vikrant Sudhakar, and Kulbhushan A. Sasane. "Examining Biological Relevence of Thiazolo Thiadiazole and Thiazolo Thiazole Fused Heterocyles." In Advances in Bioinformatics and Biomedical Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7520-4.ch005.

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Aromatic Fused heterocycles containing Nitrogen (N) and Sulfur(S) has extraordinary bioactive behavior due to which they are attracting the interest of chemists worldwide &amp; thus used as a potential material in medicinal/pharmaceutical industries. The nitrogen-sulphur fused heterocycles attracting attention of the researchers due to number of biological and pharmacological activities and observed to exhibit extensive applications in drug discovery and development. The efforts are made to understand biological activity based on position of heteroatom &amp; the substituent present in 5-member
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Sharma, U., D. Parmar, Sumit, and Manisha. "15.3.5 Synthesis of Quinoline Derivatives by Modification of a Methyl Substituent at the C2 or C8 Position." In Knowledge Updates 2024/2. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-115-01542.

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Abstract This review is an update contribution covering methodologies reported between the years 2005–2022 for the side-chain modification of quinolines. The focus is on the literature published for the transformation of a “methyl group” at the C2 and C8 position of quinoline. Various metal-catalyzed and metal-free protocols for C(sp3)—H functionalization are described.
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"Rational design, synthesis and biological evaluation of dual- binding reversible inhibitors of cholinesterase’s with mild inhibitory potency toward monoamine oxidase B." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.21.3.

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Alzheimer’s disease (AD) is neurodegenerative disease that is the cause of 60-70% of dementia cases. The major symptoms of AD involve progressive decline of cognitive and motor skills, caused by neuropathological changes, including elevation of oxidative stress, shrinkage of neurons, formation of Aβ plaques and neurofibrillary tangles in the central nervous system (CNS) and disruption of glutamatergic and cholinergic neurotransmission systems. In AD, the nerve terminal disruption is observed in immediate vicinity of Aβ plaques. Peripheral ionic site of AChE promotes aggregation of Aβ peptides
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Ulrich, H. "Modification of Substituents in the α-Position." In Five-Membered Hetarenes with One Chalcogen and One Additional Heteroatom. Georg Thieme Verlag KG, 2002. http://dx.doi.org/10.1055/sos-sd-011-01138.

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Calvert, Jack G., Roger Atkinson, Karl H. Becker, et al. "Reactions Of O(3P) Atoms With Aromatic Compounds." In The Mechanisms Of Atmospheric Oxidation Of Aromatic Hydrocarbons. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195146288.003.0005.

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Abstract Reactions of 0(3P) atoms with aromatic compounds are of little importance in the ambient atmosphere, but may be significant in laboratory irradiations of NOX aromatic-air mixtures and possibly also in plumes containing elevated concentrations of NO 2. As with most other classes of atmospheric reactions, there is a substantial database concerning the kinetics of the reactions of 0(3 P) atoms with aromatic compounds, but relatively few product studies have been performed. Analogous to the OH-and NO rradical reactions reviewed in previous chapters, reactions of the 0(3P) atom with aromat
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"Product Class 10: Saturated and Unsaturated Ketones with an Additional Carbonyl, Nitrile, or Carboxy Substituent or Equivalent at a β- or More Remote Position: Synthesis of the Ketone Functionality." In Category 4, Compounds with Two Carbon Heteroatom Bonds, edited by Cossy. Georg Thieme Verlag, 2005. http://dx.doi.org/10.1055/sos-sd-026-01067.

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Conference papers on the topic "Substituent position"

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Chagarovskiy, Alex, Olga Ivanova, and Igor Trushkov. "Donor-acceptor cyclopropanes with nucleophilic group at ortho-position of donor aromatic substituent." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018466.

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Rashid, Shadatul Hanom, and Siti Khadijah Ishak. "Investigation of substituent position effects of Schiff base compounds on mild steel corrosion." In INTERNATIONAL CONFERENCE ON APPLIED COMPUTATIONAL INTELLIGENCE AND ANALYTICS (ACIA-2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0127507.

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Hanoon, Haitham Dalol, Elaheh Kowsari, Mohammad Hadi Ghasemi, and Hassan Zandi. "The effects of substituent type and position on the aromaticity of certain derivatives of imidazole and benzimidazole." In INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0027541.

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Lazić, Anita, Luka Matović, Jelena Lađarević, Aleksandra Mašulović, Kristina Gak Simić, and Nataša Valentić. "In vitro antioxidant activity evaluation of ferrocenyl chalcones." In 36th International Congress on process engineering. SMEITS, 2023. http://dx.doi.org/10.24094/ptk.023.207.

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Ferrocene derivatives are known as antioxidants, antiparasitic, antitumor, antiviral, antibacterial and antifungal agents. In addition to applications in medicinal chemistry and drug design, ferrocene derivatives are of exceptional importance in synthetic organic chemistry, especially in catalytic asymmetric transformations. They are also used in electrochemistry and polymer chemistry, as additives in fuels, as chemosensors in agrochemistry and biosensors of glucose and active components in molecular electronics. To design new antioxidant agents, five ferrocenyl chalcones were synthesized, and
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Andrić, Deana B., Slađana Dukić-Stefanovic, Jelena Z. Penjišević, et al. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL N- {4-[2-(4-ARYL-PIPERAZIN-1-YL)-ETHYL]-PHENYL}-ARYLAMIDES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.355a.

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5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disorders, such as schizophrenia and depression. As a part of ongoing research, we designed series of new compounds that share arylpiperazine common structural motif with the 5HT1A receptor ligand aripiprazole. Receptor-ligand interactions were determined by the molecular docking simulations, revealing the positive impact of the phenyl substitution in the arylpiperazine part of the molecules. Nine selected compounds were synthesized in four reaction steps in high overall yields (59-73%). In vitro pharm
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Hocek, Michal, Peter Šilhár, Martin Kuchař, Zbyněk Hasník, and Vítězslav Bambuch. "Purine bases and nucleosides bearing functionalized C-substituents in position 6. Synthesis and biological activities." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810164.

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Iazykov, Mykyta, Moisés López, Juan Santaballa López, and Ludmila Rublova. "Relations structure-reactivity and the positive steric effects of ortho substituents in arenesulfonyl chlorides." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-f002.

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Jovanović-Šanta, Suzana S., Aleksandar M. Oklješa, Antos B. Sachanka, Yaraslau U. Dzichenka, and Sergei A. Usanov. "17-SUBSTITUTED STEROIDAL TETRAZOLES – NOVEL LIGANDS FOR HUMAN STEROID-CONVERTING CYP ENZYMES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.336js.

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In animal and human organisms, there are many enzymes, members of the family of heme- containing proteins, cytochromes P450 (CYPs), included in the biosynthesis and metabolism of many biomolecules, as cholesterol, bile acids, sex, and corticosteroid hormones, as well as in metabolism of drugs and xenobiotics. It is also well-known that different imidazole and triazole derivatives are efficient inhibitors of CYPs activity. In this study, we present in vitro screening of binding of novel androstane derivatives with tetrazole- containing substituents in position 17 to human recombinant steroid-co
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Ostrowski, Tomasz, Joanna Zeidler, Tomasz Goslinski, and Bozenna Golankiewicz. "Aralkylation reactions of 3,9-dihydro-3-R1-6-R2-9-oxo-5H-imidazo[ 1,2-a]purines directed by substituents in 3 and 6 positions." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902237.

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Ludwig, M., and S. A. Asher. "UV Resonance Raman Studies of Aromatic Amino Acids and Proteins." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.pdp3.

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Abstract:
The ultraviolet resonance Raman (UVRR) excitation profiles have been measured for the aromatic amino acids phenylalanine, tryptophan, tyrosine and tyrosinate. Resonance excitation enhances Raman scattering from vibrational modes that distort the ground state configuration towards the configuration of the excited state. The excitation profile maxima are red-shifted with respect to the absorption spectral maxima for each aromatic amino acid. These excitation profiles indicate the excitation required to maximally enhance a particular aromatic amino acid residue in a protein. Individual aromatic a
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Reports on the topic "Substituent position"

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Yibchok-anun, Sirintorn, and Nattaya Ngamrojanavanich. Structure-activity relationships of trans-cinnamic acid derivatives on inhibitions of alpha-glucosidase. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.86.

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Abstract:
Trans-Cinnamic acid and its derivatives were investigated for the a-glucosidase inhibitiory activity. 4-methoxy-trans-cinnamic acid and 4-methoxy-trans-cinnamic acid ethyl ester showed the highest potent inhibitory activity among those of trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid altered the a-glucosidase inhibitory activity. Increasing of bulkiness and the chain length of 4-alkoxy substituents as well as the increasing of the electron withdrawing group have b
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