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Dissertations / Theses on the topic 'Substituted [3'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Carolan, Sean Patrick Walter. "Routes to simple 3-substituted oxetanes." Thesis, University of Salford, 1992. http://usir.salford.ac.uk/14765/.

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This thesis describes syntheses and attempted syntheses of certain 3-substituted oxetanes. Simple oxetanes bearing reactive substituents in the 3-position are required since the polymerisation of these compounds is anticipated to lead to polymers of potential use as energetic binders in rocket propellant systems. Oxetanes of particular interest are 3-hydroxyoxetane, 3,3-bis(hydroxymethyl)oxetane, and 3-(hydroxymethypoxetane. 3-Hydroxyoxetane was prepared in three steps from epibromohydrin (I). Firstly, Lewis acid-catalysed ring opening of the epoxide in the presence of acetic acid gave the bro

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2

Hutchinson, Ian Paul. "The synthesis of 3-substituted-2-(nitromethylene)-piperidines." Thesis, University of Warwick, 1994. http://wrap.warwick.ac.uk/104212/.

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The class of insecticides known collectively as the nitromethylene heterocycles (NMHs) were discovered in the late 1970's. The NMHs are a group of compounds that are particularly active against certain insects, exhibit low toxicity to vertebrates and are non-persistent in the environment. Their site of action is on the cholinergic synapse where they act as agonists at the post-synaptic nicotinic acetylcholine receptors. Research into developing these types of compounds has led to a wide range of analogues being synthesised, resulting in a wide variety of activities. Analogues of 2- (nitromethy

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3

Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

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4

Velioglu, Ozlem. "Synthesis Of Ferrocenyl Substituted Quinolines." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609785/index.pdf.

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Quinolines have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of quinolines with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted quinolines, such as 2-ferrocenylquinoline, by

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5

Steele, John Edward. "Studies related to chromenes." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308349.

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6

Ehrhardt, Katharina. "Redox-active 3-benzyl-menadiones as new antimalarial agents : studies on structure-activity relationships, antiparasitic potency and mechanism of action." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF020.

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Le paludisme reste une des maladies infectieuses les plus importantes au monde. Récemment, le laboratoire de Dr E. Davioud-Charvet a conçu des 3-Benzyl-Ménadiones substituées (benzylMD) comme agents antipaludiques prometteurs. Les études sur le mode d'action ont mis en évidenceque ces molecules déstabilisent l'équilibre redox des érythrocytes infectés en agissant comme agent catalytique redox (redox-Cycler), une stratégie prometteur pour le développement de nouveaux agents antipaludiques. Le travail de thèse présenté a caractérisé l'activité in vitro et le mécanisme d'action de tête de série,

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Salandria, Kerry Jane. "DNA Minor Groove Modifications: Synthesis and Application of 3-deaza-3-substituted-2'-deoxyadenosine Analogues." Thesis, Boston College, 2011. http://hdl.handle.net/2345/2754.

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Thesis advisor: Larry W. McLaughlin<br>Nucleic acids are fundamental biomolecules responsible for all activities of a living cell. DNA serves as an instruction manual to the cell, containing blueprints and directions for all cellular processes, while RNA serves to carry out the messages held within DNA. Research into the structure, stability, and function of nucleic acids has revealed much about the origin and evolution of life. The ultimate goal of this work is to understand how molecules bind and associate within the minor groove of double stranded, helical DNA. A series of 2'-deoxyadenosine

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8

Svogie, Archibald Lesley. "Investigation of α-aryl substituted 3-indolylethanones as potential antiplasmodial agents". Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/55487.

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According to the World Health Organisation (WHO), deaths attributed to Plasmodium falciparum exceeded 584 000 in 2013, with 198 million new cases of malaria being reported. One contributing factor to these alarming figures is the emergence of drug resistance against available antimalarial agents. Therefore, there is a pressing need to develop new therapeutic antimalarial drugs with novel mechanisms of action in order to curb the increasing spread of malaria. The indole scaffold is often associated with biologically active compounds, recently exemplified by the antimalarial agent NITD609, which

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9

Williams, Colin Stephen. "An enantioselective synthesis of substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278236.

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10

Tirkes, Seha. "Synthesis, Characterization, And Polymerization Of Polyether Bridged Thiophene And Aniline Derivatives." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609399/index.pdf.

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New compounds consisting of 3-thienyl and aniline units linked by polyether bridges have been synthesized and their electrochemical polymerization was performed via constant potential electrolysis and cyclic voltammetry. In the case of 3-thienyl derivatives two compounds, 1,12-di-3-thienyl-2,5,8,11-tetraoxadodecane (MI) and 1,15-di-3-thienyl-2,5,8,11,14-pentaoxapentadecane (MII) were synthesized utilizing literature methods and their corresponding polymers, poly(I) and poly(II) were prepared in an electrolytic solution containing 0.1 M terabutylammonium hexafluorophosphate (TBAPF6) dissolved i

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11

Oleksik, Laurence. "Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30087.

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Initially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported. The selective synthesis of a range of alpha-aryl vinyl ethers using Heck chemistry is then reported. Subsequent perfluoroacylations of the vinyl ethers followed by reaction of the resulting perfluoroacyl enol ethers with hydrazine affords a range of 5-aryl-3-perfluoroalkyl pyrazoles in good yields.;Alternative methodology for the synthesis of 5-aryl-3-perfluoroalkyl pyrazoles is then described

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12

Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t

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13

Simpson, Linda. "Trivalent group 13 metal complexes of N-substituted-3-hydroxy-2-methyl-4-pyridinones." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28885.

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The compounds tris(N-ռ-propyl-3-hydroxy-2-methyl-4-pyridinonato) aluminum(III), -gallium(III), and -indium(III) and tris(N-ռ-butyl-3-hydroxy-2-methyl-4-pyridinonato)aluminum(III), -gallium(III), and -indium(III) were synthesized. All six compounds were prepared via the metal template effect. They were characterized by IR, FAB-MS, ¹H NMR, ²⁷Al NMR, and elemental analysis. Three of the six complexes were studied by single-crystal X-ray diffraction. They formed trihydrates, unlike their N-methyl and N-ethyl analogues, which formed dodecahydrates. The ռ-butyl complex Al(C₁₀H₁₄N0₂)₃‧3H₂0 (1) and ռ-

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14

Arefalk, Anna. "New Methods for the Synthesis of 3-Substituted 1-Indanones : A Palladium-Catalyzed Approach." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6015.

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15

Kozera, Daniel James. "Ring-opening metathesis polymerization of 3-substituted cyclooctenes initiated by group 6 alkylidene complexes." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78531.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The highly cis,head-to-tail (cis,HT) selective ring-opening metathesis polymerization of 3-substituted cyclooctenes (3-RCOE; R = methyl, hexyl, phenyl) initiated by high oxidation state M and W alkylidene complexes is described herein. W(NtBu)(CHCMe₃)(pyr)(OHMT) combined high cis,HT selectivity (>98% cis,HT) with high activity, achieving 76% conversion of 5000 equivalents of 3-HexCOE after 24 h at room temperature. The resulting cis

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16

Arico, Joseph William. "3-Substituted Purines: Methodology, Synthesis, and Studies of DNA Hydration in the Minor Groove." Thesis, Boston College, 2010. http://hdl.handle.net/2345/1824.

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Thesis advisor: Mary F. Roberts<br>As the central repository of biological information and ultimate mediator of all processes underlying the activities of living organisms, nucleic acids are the sine qua non for life as we know it. Biological research over the past century and more has revealed much of the structure and function of nucleic acids, revealing in turn how life begins, changes, reproduces, and ends. We glimpse how life has become what it is and perhaps what it may become. This work seeks to understand the ramifications of altering a single nitrogen of the purine nucleoside componen

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17

Pinar, Ayse Nur. "Reaction Of Propargyl Aldehydes With Hydrazinium Salts: Synthesis Of Ferrocenyl And Phenyl Substituted Pyrazoles." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609769/index.pdf.

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Pyrazoles have been focus of a large number of investigations in the design and synthesis of novel biologically active agents that show remarkable medicinal activities. Although pyrazoles have been studied for over a century as an important class of heterocyclic compounds, they still continue to attract considerable attention due to the wide range of medicinal activities they possess. Recent studies have shown that combination of a ferrocenyl unit with structural features of pyrazoles can lead to products with enhanced or/and unexpected biological activity since several ferrocene derivatives h

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18

Camurlu, Pinar. "Syntheses Of Conducting Polymers Of 3-ester Substituted Thiophenes And Characterization Of Their Electrochromic Properties." Phd thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/12607773/index.pdf.

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In this study three different 3-ester substituted thiophene monomers were synthesized via esterification reaction of 3-thiophene ethanol with adipoyl chloride or sebacoyl chloride or octanoyl chloride in the presence of triethylamine at 00C. Characterizations of the monomers were performed by 1H-NMR, 13C-NMR, FTIR, DSC, TGA techniques. Electrochemical behavior of the monomers both in presence or absence of BFEE were studied by cyclic voltammetry. Results showed the astonishing effect of BFEE on the polymerization, where free standing films of the homopolymers could be synthesized. Copolymers o

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19

Aziz, Y. F. A. "The metal complexes of 3-hydroxyflavone and tin(IV) complexes of catechol and substituted catechol." Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233191.

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20

Vahedi, Hooshang. "Catalytic symmetric oxidation of sulfides to sulfoxides mediated by 3-substituted-1,2-benzisothiazole 1,1-dioxides." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367257.

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21

Baikstis, Tomass. "Rhodium-catalysed [(3+2)+2] carbocyclisation of heteroatom-substituted alkenes and synthetic studies towards (+)-repin." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2010539/.

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The stereoselective construction of fused 5,7-bicycles has attracted considerable attention due to the ubiquity of this motif in complex biologically active sesquiterpene lactones (dehydrocostus lactone, helenalin). Transition metal-catalysed carbocyclisation reactions represent a highly attractive approach towards the construction of functionalised cyclic and polycyclic molecules. Generation of 5- and 7-membered rings from strained 3-membered cycles has emerged as a particularly effective strategy, which is complementing more traditional pericyclic reactions. The description of the transition

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22

Shalabi, Abdelrahman R. "Structure-Activity Relationship Studies of Bupropion and Related 3-Substituted Methcathinone Analogues at Monoamine Transporters." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5176.

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The khat plant, catha edulis, has been abused for some time in the Middle East and the African horn for its short-term stimulant effects. However, it was not until 1975 when cathinone, β-ketoamphetamine, was identified as the major stimulant component of khat. Structural analogues of cathinone, synthetic cathinones, are new psychoactive substances available on the clandestine market of numerous countries including the USA. Abuse of these new illicit stimulants is a worldwide growing health concern which necessitates the investigation of the pharmacological properties of these new drugs of abus

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23

Kapakli, Fadile. "New Strategy For The Synthesis Of Chiral N-substituted-3,4-dialkoxypyrrole From 2,5-dihydro-2,5-dimethoxyfuran." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607334/index.pdf.

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NEW STRATEGY FOR THE SYNTHESIS OF CHIRAL N-SUBSTITUTED-3,4-DIALKOXYPYRROLE FROM 2,5-DIHYDRO-2,5-DIMETHOXYFURAN KAPAKLI, FADiLE M.S., Department of Chemistry Supervisor : Prof. Dr. Cihangir Tanyeli July 2006, 80 pages Pyrroles are very valuable class of substances which have wide usage area in organic synthesis. In this study, chiral 3,4-dialkoxy-N-substituted pyrrole derivatives were synthesized. These compounds are widely used as building blocks for the synthesis of natural compounds that have focused on heterocyclic rings in their structures. In addition, chiral pyrrole derivatives can

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Emrullahoglu, Mustafa. "Novel Annulation Reactions For The Synthesis Of Substituted Pyrroles Darzens Reaction Of Acyl Phosphonates With &amp." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610338/index.pdf.

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In the first part of this thesis, it is aimed to develope methods for the synthesis of trisubstituted pyrrrole derivatives. 2-Aminopyrrroles, alkoxy and sulfonyl substittitued pyrrole derivatives as well as pirolinones show interesting biological activities and are precursor of well know drugs. Although there is a number of methods for the synthesis of pyrroles, the synthesis of 2-aminopyrroles is limited to few works and is not widely known. Therefore, it is still an important goal in organic chemistry to improve methods for the synthesis of multifunctionalized pyrrole derivatives and pyrroli

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Gunatunga, Sumudu Rupika. "Synthesis and characterisation of 3-alkyl substituted 2,5-thiophene oligomers as models for poly(alkylthiophene)s." Thesis, University of Sussex, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262663.

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Woon, Esther Chue Yen. "Studies on 3-substituted isoquinolin-1(2H)-ones designed as inhibitors of poly(ADP-ribose) polymerase." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401288.

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Cantekin, Seda. "The Development Of The Novel Synthesis For Conduritols." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607609/index.pdf.

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Conduritols have attracted a great deal of attention in recent years owing to biological activities exhibited by them and also their usefulness in the synthesis of other natural products and pharmaceuticals. Conduritols show interesting inhibitor activity for some glycosidases and serve as important intermediates in the synthesis of inositols. In this study, novel synthetic strategies leading to highly functionalized cyclohexene derivative containing an aromatic ring, namely phenyl-substituted conduritol was achieved successfully for the first time. As the starting material, substituted benzoq

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28

Goetz, Alice-Anne. "Propriétés antiparasitaires des benzyl-ménadiones : étude de leur mécanisme d'action et de leur potentiel à bloquer la transmission des parasites du paludisme au moustique vecteur Anopheles gambiae." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ115.

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La plasmodione est une benzylmenadione (bMD) qui a été désignée comme inhibiteur subversif de flavoenzymes. Ces enzymes utilisent FAD comme co-facteur et sont impliquées dans de nombreux processus biologiques, et notamment dans le maintien de l’homéostasie redox par les systèmes thiorédoxine et glutathion. La plasmodione présente une forte activité contre P. falciparum in vitro, elle est actif sur tous les stades asexués, préférentiellement sur les stades anneaux, avec une vitesse d’élimination des parasites très rapide. Mon objectif a été de tester sa capacité à bloquer la transmission du par

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Subramanian, Pritha. "Development of Synthetic Approaches Towards 2-Substituted 3- and 4-Fluorothiophene Building Blocks and their Application in Liquid Crystal Synthesis." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1375104882.

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Kelm, Bernd. "A new synthesis of enantiopure C-3-substituted glutamates by utilization of ortho ester protected (S)-pyroglutamic acid." Doctoral thesis, [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965970167.

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Turner, Michael R. "Novel palladium catalyzed synthesis of 3-substituted indoles and its application toward the total synthesis of indolactam V." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1585.

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Thesis (M.S.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 51, 28 p. : ill. Includes abstract. Includes bibliographical references (p. 49-51).

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Vakifahmetoglu, Cekdar. "Production And Properties Of Glass Bonded Apatite-wollastonite Bioceramics." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12605852/index.pdf.

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Apatite containing bioceramic materials are considered to be potentially useful for replacement or repair of natural bone. In the present study, the aim was to produce a new composite bioceramic containing crystalline apatite and wollastonite phases with a bimodal grain size distribution. The manufacturing scheme was based on the liquid phase sintering process in which the compacts pressed from powders of apatite (HAP or Si&shy<br>HAP) and pseudowollastonite was sintered in the presence of a liquid phase. Three distinct fluxing agents, magnesium flux (MCAS), sodium feldspar and sodium frit (NC

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Cihaner, Atilla. "Electrochemical Synthesis Of Crowned Conducting Polymers: Nature Of Radical Cations In Polymerization And Mechanism Of Conductivity." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605054/index.pdf.

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ABSTRACT ELECTROCHEMICAL SYNTHESIS OF CROWNED CONDUCTING POLYMERS: NATURE OF RADICAL CATIONS IN POLYMERIZATION AND MECHANISM OF CONDUCTIVITY Cihaner, Atilla Ph. D., Department of Chemistry Supervisor: Prof. Dr. Ahmet M. &Ouml<br>nal June 2004, 96 Pages Poly(dibenzo-18-crown-6) (Poly(DB18C6)) was synthesized by electrochemical oxidation of dibenzo-18-crown-6 (DB18C6) using a mixture of acetonitrile and dichloromethane as solvent and tetrabutylammonium tetrafluoroborate (TBABF4) or tetrabutylammonium hexafluorophosphate (TBAPF6) as supporting electrolyte. The anodic polymerization of DB18C

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Edwards, Paul John. "Aspects of substituted hydrazine chemistry : the N-N bond as a chiral axis in 3-acylaminoquinazolin-4(3H)-ones." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/33662.

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The work contained in this thesis examines the aziridination of a number of ?-diketones via their enol forms using oxidative addition of N-aminoquinazolin-4(3H)-ones, to give N-(quinazolinone-N'-y1)-N-acyl-a-aminoketones which result from C-C cleavage of the intermediate aziridine ring. Products which have the N-N bond di-acylated are primed for reductive cleavage. One example has been studied in which reduction was successfully accomplished using aluminium amalgam to afford an N-acylated amino acid ester in good yield. The N-acetoxyaminoquinazolinone has been shown to function as an NH2+ equi

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Inaoka, Seiji. "A study of electronically conductive polymers : substituted dithieno[3,4-B:3',4'-d]thiophenes and substrate modification with monomer adsorbates." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/27338.

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Subramanian, Pritha. "Development of synthetic approaches towards 2- substituted 3- and 4-fluorothiophene building blocks and their application in liquid crystal synthesis." Thesis, Kent State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3618847.

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<p> Thiophene-containing liquid crystals (LCs) often exhibit attractive physical characteristics for use as ferroelectric materials, which offer several advantages for display applications. In addition, fluorine substituents on the aryl core of LCs are known to confer favorable LC properties; they often suppress or eliminate higher ordered smectic mesophases and improve dielectric anisotropy, viscosity and melting points. However, the development of smectic ferroelectric LC devices has proven challenging due to chevron defects. Our goal is to further understand structure-mesophase property rel

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Bhat, Shreesha V. "Synthesis of 1,2,4 oxadiazol-5-imine, 1,2,4-triazol-3-imine and derivatives : a substituted cyanamide-based strategy for heterocycle synthesis." Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/28632/.

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Considering the importance of nitrogen-rich heterocycles in drug discovery, a novel strategy towards heterocycle synthesis was envisioned using cyanamide chemistry. Synthesis which involve mild conditions, avoids multi-step sequence and non-toxic reagents are desirable for generation of large combinatorial libraries of drug molecules. We envisaged that the NCN linkage of the cyanamide as well as the concomitant use of the nucleo-and electrophilic centres of the cyanamide could provide a novel synthetic route towards nitrogen heterocycles. The first part (Ch-2) constitute the bulk of the thesis

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Harn, Piin-Jye, and 韓品杰. "Oxidation of 3-Substituted Furans with Bromine." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/56086114504368500774.

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碩士<br>國立交通大學<br>應用化學系<br>83<br>3-夫喃甲醇類化合物,在丙酮與水之溶液系統下,加入溴會產生氧化重排之2-取代-3-夫喃醛類化合物.此種新反應可以將夫喃第三位置的取代基 ,轉移到夫喃的第二位置,如此就可以引進平常不易在夫喃第二位置出現的取代基.若在夫喃2位置引進取代基,即使用2-烷基-3-夫喃甲醇類化合,同樣在丙酮與水之系統下,加溴也會產生氧化重排之2-烷基-3-夫喃酮類化合物,但在其酮基之α位置有溴取代發生.若把醇類的OH基換成胺,即使用3- 夫喃甲胺類化合物,在同樣條件之下,會產生3-比各醛類化物,這是一種從夫喃直接合成比各類化合物的新穎方法. Reaction of 3-furylcarbinols with bromine in acetone-waterystem gave the 2-substituted-3-furylaldehyde. Reaction of 2-alkyl-3- furylcarbinols with bromin

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Leboho, Tlabo Caiphus. "The synthesis of 2- and 3-substituted indoles." Thesis, 2009. http://hdl.handle.net/10539/6619.

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One of the main groups of organic compounds containing nitrogen in both cyclic systems and straight chains is the alkaloids. Indole is perhaps the single most common heterocycle in all of chemistry and it is embodied in a myriad of natural products, pharmaceutical agents and a growing list of polymers. This dissertation presents method for the synthesis of substituted indoles bearing aryl substituents onto the 2- and 3- position as well as 2,3-fused indoles. The route for the synthesis of the aryl substituted indoles starts from the indole nucleus which was protected using the phenylsulf

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Tsai, Mei-Wen, and 蔡美雯. "Synthesis and Vasorelaxant Activity of 3- Substituted Benzopyrans." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/09657629702692207561.

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碩士<br>中國文化大學<br>應用化學研究所<br>88<br>ABSTRACT Ion channels, including sodium, calcium, and potassium channels, are present in all mammalian cells and play a major role in the control of a variety of physiological functions. Sodium channel blockers have been used for many years as local anesthetics (procaine and xylocaine) and antiarrhythmics (procainamide and lidocaine). Subsequently calcium channel blockers underwent a vigorous development and resulted in a number of drugs such as nifedipine and verapamil that are used in cardiovascular diseases. Currently there is an increasing int

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DING, SU-HUA, and 丁穌華. "The reactions of 3-substituted catechols with metapyrocatechase." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/34890547767278184052.

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碩士<br>國立成功大學<br>化學研究所<br>81<br>3-取代基兒茶酚(3-substituted catechols) 的一般合成法已被建立。一系列的取代基諸如氯基、甲基、甲醛基、羧基及乙醯基等皆可由鄰苯二酚丙縮酮 (2,2- dimethyl-1,3-benzo-dioxole) 經鋰化後，再與嗜電子基作用，而被導入兒茶酚衍生物的第三位置上。 3-取代基兒茶酚為偏鄰苯二酚雙加氧 (metapyro-catechase，簡稱MPC)的主要受質，實驗更進一步證明，3-氯兒茶酚為酵素MPC 的基理型抑制劑(mechanism-based inhibitor)。有關此系列化合物與酵素MPC 行氧化催化反應的Ｋm 及與兒茶酚競爭抑制的Ｋi 亦被探討。比較3-取代基（氯基、甲基、甲醛基、羧基）兒茶酚的Ｋm與Ｖmax，可歸納為3-取代基兒茶酚與酵素MPC 的結合階段主要係受立體效應所控制，而Ｖmax 主要則取決於取代基的電子效應。

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Chiu, Shih-long, and 邱世龍. "Synthesis And Characterization Of 3-Substituted Coumarine Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/90783774671413130935.

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碩士<br>桃園創新技術學院<br>材料應用科技研究所<br>100<br>Cyclocondensation reaction of appropriate salicylaldehydes with acetoacetic ethyl acid in the presence of piperidine to yield the corresponding substituted 3-acety-comarine derivatives, which condensed with DMFDMA in the presence of toluene afforded the corresponding 3-(3-dimethylamino-acryloyl)-coumarine derivatives. On the other hand, a series of novel 3-[7-substituted-8-(4-substituted-phenyl)azo-pyrazol[1,5- a]pyrimidine]-coumarines were also obtained by the intramolecular cyclization of 3-(3-dimethylamino-acryloyl)-comarine derivatives with appropriate

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Ting, Su Hwa, and 丁穌華. "The Reactions of 3-Substituted Catechols with Metapyrocatechase." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/08378194835800161001.

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碩士<br>國立成功大學<br>化學學系<br>82<br>3-取代基兒茶酚(3-substituted catechols) 的一般合成法已被建立。一系列的取代基諸如氯基、甲基、甲醛基、羧基及乙醯基等皆可由鄰苯二酚丙縮酮(2,2-dimethyl-1,3-benzodioxole) 經鋰化後，再與嗜電子基作用，而被導入兒茶酚衍生物的第三位置上。 3-取代基兒茶酚為偏鄰苯二酚雙加氧■(metapyrocatechase，簡稱 MPC)的主要受質，實驗更進一步證明，3-氯兒茶酚為酵素MPC 的基理型抑制劑(mechanism-based inhibitor)。有關此系列化合物與酵素MPC 行氧化催化反應的Km及與兒茶酚競爭抑制的Ki亦被探討。比較3-取代基( 氯基、甲基、甲醛基、羧基) 兒茶酚的Km與Vmax，可歸納為3-取代基兒茶酚與酵素MPC 的結合階段主要係受立體效應所控制，然而Vmax主要則取決於取代基的電子效應。 A general method in the sy

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Lin, Chung-Han, and 林宗漢. "Synthetic Studies Toward 3- or 4-Substituted Piperidines." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/47855543403551959324.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>99<br>Piperidine derivatives usually have a significant biological activity. This study is divided into three themes: (1) BF3–OEt2 promoted synthesis of spiroindenyl heterocycles. (2) N-bromosuccinimide promote rearrangment of 4-diarylmethylene piperidines. (3) Nucleophilic substitution studies of 3-diarylmethylene piperidines by trimethylsilyl-catalyst (TMS-Y). These novel synthetic methods are more direct and rapid synthetic approches to the piperidine skeletons.

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許智雄. "Synthesis and Mesogenic Properties of Bent-shaped and Discotic Liquid Crystals Containing 1, 3-Substituted and 1, 3, 5-Substituted Aromatic Ring." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/00290733952874092584.

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碩士<br>高雄師範大學<br>化學系<br>97<br>Three series of liquid crystal compounds were synthesized to study the influence of the structure of terminal group or substituent group on the mesogenic behavior of calamitic liquid crystals or bent-shaped liquid crystals or discotic liquid crystals.The results of liquid crystal properties are summarized as follows： (1)The compounds of BnOSC3~BnOSC6 all possess smectic A phase. When the cycloalkyl ring is smaller, the liquid crystal molecules except BnOSC6 tent to form nematic phase.They have broader mesogenic temperature range. (2)The compounds of HOSC3、

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Li, Jin-Xing, and 李錦星. "Synthesis and Electrochemical Characterization of Poly(pyrrole) s,N-Substituted and 3-Substituted with Mesogenic Groups." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/94935264941655802753.

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Li, Chin-Hsing, and 李錦星. "Synthesis and Electrochemical Characterization of Poly(pyrrole) s,N-Substituted and 3-Substituted with Mesogenic Groups." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/39073904244410752413.

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碩士<br>國立台灣工業技術學院<br>化學工程技術研究所<br>85<br>A series of novel liquid crystalline monomers based on N- substituted and 3-substituted pyrrole with varying the spacer length of alkylene and pentyl- or cyano- tail group on biphenyl mesogenic cores were synthesized. These monomers were polymerized by electrochemical method to yield conjugative polypyrrole with biphenyl-based mesogenic cores as the side groups.All the eight prepared monomers can be classified into two series; the first series is the N

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Jarvis, Scott. "Enantiopure 3-substituted piperidines via an aziridinium ion ring expansion." Thèse, 2011. http://hdl.handle.net/1866/6878.

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Ce mémoire décrit le développement d’une nouvelle méthodologie d’expansion de cycle irréversible à partir de N-alkyl-3,4-déhydroprolinols pour former des N-alkyl tétrahydropyridines 3-substituées en passant par un intermédiaire aziridinium bicyclique. Cette méthode permet l’introduction d’un vaste éventail de substituants à la position 3 et tolère bien la présence de groupements aux positions 2 et 6, donnant accès à des pipéridines mono-, di- ou trisubstituées avec un excellent diastéréocontrôle. De plus, il est démontré que l’information stéréogénique du 3,4-déhydroprolinol de départ est tota

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Guo, Fang Ling, and 郭芳伶. "Acid-catalyzed polymerization of 2 and/or 3-substituted thiophenes." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/v868d9.

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Huang, Shu-Ru, and 黃淑如. "Regioselectivity in Friedel-Crafts Acylation Reaction:3- Substituted Phthalic Anhydrides." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/58048175611625547153.

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