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Journal articles on the topic 'Substituted Flavones'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Khan, Sumaiya, Umme Aiman Liza, Dipan Banik, et al. "Environmentally benign synthesis of substituted iodinated flavones as precursors for prenyl-/geranyl flavones from the corresponding chalcones." European Journal of Chemistry 15, no. 4 (2024): 332–37. https://doi.org/10.5155/eurjchem.15.4.332-337.2600.

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Flavones have biological properties because of the existence of oxoheterocyclic ring moieties, and day by day create research interest areas because of their important biological activity. Iodine-substituted flavones were synthesized from the corresponding chalcones through an exhaustive iodination reaction. Generally, it is seen that halogenated flavones show better biological activity. Moreover, the introduction of iodine in the ring moiety facilitates the incorporation of highly active side chains, such as prenyl and geranyl groups through the formation of C-C bonds by numerous coupling rea

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2

Kónya, Krisztina, and Zoltán Sipos. "Synthesis of Benzopyran-Fused Flavone Derivatives via Microwave-Assisted Intramolecular C–H Activation." Synthesis 50, no. 08 (2018): 1610–20. http://dx.doi.org/10.1055/s-0036-1591773.

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A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.

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3

Nikolova, M., and S. Ivancheva. "Distribution of Surface Flavonoids in Bulgarian Plants." Natural Product Communications 1, no. 11 (2006): 1934578X0600101. http://dx.doi.org/10.1177/1934578x0600101119.

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The review describes the distribution of surface flavonoids in Bulgarian plants. More than 100 species of Asteraceae, Lamiaceae, Scrophulariaceae, Geraniaceae and other families have been checked for external flavonoid aglycones. The flavonoid profiles of Asteraceae species are composed of a wide array of flavones and flavonols, mainly based upon 6-substituted derivatives. Flavone aglycones are predominant in the exudates of Lamiaceae species. Apigenin, luteolin and their derivatives were most commonly found in the studied species of Scropulariaceae and Lamiaceae. It has been shown that specie

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4

Patel, Samir, and Umang Harishchandra Shah. "SYNTHESIS OF FLAVONES FROM 2-HYDROXY ACETOPHENONE AND AROMATIC ALDEHYDE DERIVATIVES BY CONVENTIONAL METHODS AND GREEN CHEMISTRY APPROACH." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 403. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15928.

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Objective: Flavones occupy a special place in the realm of natural and synthetic organic chemistry owing to their diversified biological activities. In this study, a series of chalcone derivatives were synthesized and after cyclization of chalcone to synthesized various substituted flavone derivatives (2A-2L). 2 Methods: The reaction of 2-hydroxy acetophenone with substituted aromatic aldehydes produced chalcone by trituration (NaOH) and conventional methods (KOH/EtOH), which upon further cyclization with dimethyl sulfoxide/I resulted to form flavone derivatives.Results: The purity of compound

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5

Chniti, Sami, László Kollár, Attila Bényei, Ágnes Dörnyei, and Attila Takács. "A Facile Route to Flavone-3-Carboxamides and Flavone-3-Carboxylates via Palladium-Catalyzed Amino- and Aryloxy-Carbonylation Reactions." International Journal of Molecular Sciences 25, no. 18 (2024): 10128. http://dx.doi.org/10.3390/ijms251810128.

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A library of C-3 functionalized flavones was successfully provided via palladium-catalyzed amino- and aryloxycarbonylation reactions of 3-iodoflavone (1), under mild conditions. This methodology showed good functional group tolerance using a variety of amines and phenols, under an atmospheric pressure of carbon monoxide as a carbonyl source. While the flavone-3-carboxamides (2a-t) were produced in 22–79%, the flavone-3-carboxylates (4a′-l′) were obtained in excellent yields (up to 88%), under identical reaction conditions, just by switching N-nucleophiles to O-nucleophiles. The convenient avai

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6

Shoaib, Mohammad, Syed Wadood Ali Shah, Niaz Ali, et al. "In VitroEnzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives." Journal of Chemistry 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/516878.

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Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2–F5) have been synthesized fromo-hydroxyacetophe

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7

Rumbero, Angel, Fco Javier Arriaga-Giner, and Eckhard Wollenweber. "A New Oxyprenyl Coumarin and Highly Methylated Flavones from the Exudate of Ozothamnus lycopodioides (Asteraceae)." Zeitschrift für Naturforschung C 55, no. 1-2 (2000): 1–4. http://dx.doi.org/10.1515/znc-2000-1-202.

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Abstract A new oxyprenyl coumarin was isolated from the lipophilic exudate of Ozothamnus lycopodioides. Its structure was established as 7-(3,3′-dim ethylallyloxy)-5-hydroxy-6-methoxycoumarin from its UV, MS and NMR spectral data, especially two dimensional experiments. In addition to six earlier reported flavonols, we found four highly substituted flavones, including two rare methylenedioxyflavones.

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8

Ismailova, Gulzira, Shakhnoza Abzalova, Zulfiya Ikramova, Bakhromkhodja Aykhodjaev, and Sabirdjan Arifdjanov. "Synthesis of Some Substituted Analogues of Natural Flavones and Chalcones." International Journal of Psychosocial Rehabilitation 24, Special Issue 1 (2020): 840–44. http://dx.doi.org/10.37200/ijpr/v24sp1/pr201226.

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9

William, Helen, and Narayanan N. "COMPARATIVE EVALUATION OF ANTIOXIDANT ACTIVITY OF SUBSTITUTED FLAVONES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 288. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.18973.

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Objective: The flavonoids are a heterogeneous group of plant polyphenols that are endowed with several biological activities including antioxidant, anti-inflammatory, immunomodulatory, antiviral, antimutagenic, and anticarcinogenic properties. They are believed to interfere with the various free radical-producing systems and they also enhance the functions of endogenous antioxidants. The aim of this study was to compare the antioxidant activity of synthesized substituted flavones by various free radical scavenging assays.Methods: The flavones used in the study, 6,3’,4’ - trihydroxy flavones (T

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10

Tiwari, Keshri Nath, Jean-Philippe Monserrat, Fréderic de Montigny, Gérard Jaouen, Marie-Noelle Rager, and Elizabeth Hillard. "Synthesis and Structural Characterization of Ferrocenyl-Substituted Aurones, Flavones, and Flavonols." Organometallics 30, no. 20 (2011): 5424–32. http://dx.doi.org/10.1021/om200644e.

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11

Valant-Vetschera, Karin M., Tshering Doma Bhutia, and Eckhard Wollenweber. "Exudate Flavonoids of Primula Spp: Structural and Biogenetic Chemodiversity." Natural Product Communications 4, no. 3 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400310.

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Several new accessions of the genus Primula and of the closely related Cortusa matthioli have been studied for their exudate flavonoid profiles. Unsubstituted flavone, 5-hydroxy-, 2′-hydroxyflavone and 5,2′-dihydroxyflavone were found as main components. Several other rather unusual substitution patterns were also found. 8- O-Substituted flavones appear to be accumulated more often than 6- O-substituted products. Chalcones with corresponding substitution patterns were of scattered occurrence, while flavanones could so far not be detected in exudates of Primula species. The distribution of exte

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12

Bhutia, Tshering Doma, Karin M. Valant-Vetschera, and Lothar Brecker. "Orphan Flavonoids and Dihydrochalcones from Primula Exudates." Natural Product Communications 8, no. 8 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800812.

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Two orphan flavonoids containing an oxepin structure in ring A and named as Primcortusin (1) and 3’-OH-Primcortusin (2) were isolated from leaf exudates of Primula cortusoides, while P. glutinosa exudates yielded two dihydrochalcone derivatives (3,4). These novel structures have not been detected in other species of Primula so far. Chemical structures were elucidated by 2D NMR and mass spectrometry. The nature of compounds 1 and 2 is discussed, and ideas about their possible origin and that of unsubstituted flavone and other irregular substituted Primula flavones are presented.

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13

Jung, Se-Hui, Hee-Young Heo, Jung-Won Choe, Jaehyun Kim, and Kooyeon Lee. "Anti-Melanogenic Properties of Velutin and Its Analogs." Molecules 26, no. 10 (2021): 3033. http://dx.doi.org/10.3390/molecules26103033.

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Velutin, one of the flavones contained in natural plants, has various beneficial activities, such as skin whitening, as well as anti-inflammatory, anti-allergic, antioxidant, and antimicrobial activities. However, the relationship between the structure of velutin and its anti-melanogenesis activity is not yet investigated. In this study, we obtained 12 velutin derivatives substituted at C5, C7, C3′, and C4′ of the flavone backbone with hydrogen, hydroxyl, and methoxy functionalities by chemical synthesis, to perform SAR analysis of velutin structural analogues. The SAR study revealed that the

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14

Wollenweber, Eckhard, and Marion Dörr. "Exudate Flavonoids of Some Juglandaceae." Natural Product Communications 4, no. 2 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400208.

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Six species of Juglandaceae have been checked for the occurrence of flavonoid aglycones on their leaf and fruit surfaces. Except for one, they exhibit flavonols, mostly methyl ethers of kaempferol and quercetin, including 6- O-substituted derivatives. Apigenin and acacetin are the only flavones found so far. Flavonoids accumulated on leaves are different from those excreted on green fruits. It has become evident that in future studies greater attention must be paid to the localization of flavonoid aglycones in different plant organs.

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15

Lumbiny, Bilkis Jahan, Zhang Hui, and M. Azizul Islam. "Antiaging, antioxidant flavonoids; synthesis, antimicrobial screening as well as 3D QSAR CoMFA models for the prediction of biological activity." Journal of the Asiatic Society of Bangladesh, Science 39, no. 2 (2014): 191–99. http://dx.doi.org/10.3329/jasbs.v39i2.17856.

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Flavonoids, polyphenolic heteronuclear compounds which are naturally occurring antioxidants are widely used as antiaging substances. Synthesis of new naturally occuring organic compounds with basic skeleton of chalcones, flavones and oxygenated flavones and their antimicrobial activity were reported by this research group for long. Presently comparative molecular field analysis (CoMFA) implemented in Sybyl 7.3 was conducted on a series of substituted flavones. CoMFA is an effective computer implemented 3D QSAR technique deriving a correlation between set of the biologically active molecules an

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16

Kumar, Naveen, Navneet Sharma, Vijay Kumar, et al. "Iodine-PEG as a unique combination for the metal-free synthesis of flavonoids through iodonium-triiodide ion-pair complexation." RSC Advances 14, no. 9 (2024): 6225–33. http://dx.doi.org/10.1039/d3ra08810c.

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17

Jayaprakash Rao, Y., G. Thirupathi, Ch Prasad Rao, and Y. Hemasri. "Synthesis of novel substituted pyrano annulated flavones." Russian Journal of General Chemistry 86, no. 5 (2016): 1126–31. http://dx.doi.org/10.1134/s1070363216050248.

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18

Seema, I. Habib M. A. Baseer. "A FACILE MICROWAVE ASSISTED SYNTHESIS OF FLAVONES FROM 2-HYDROXY ACETOPHENONES AND AROMATIC ALDEHYDES." International Journal of Advance and Applied Research 2, no. 20 (2022): 466–69. https://doi.org/10.5281/zenodo.7100530.

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<strong><em>Abstract</em></strong> <em>A series of heterocyclic Flavones have been synthesized with biologically active Chalcones. These chalcones were prepared by the condensation of substituted 2'-Hydroxy acetophenones and Pyridine / Pyrrole 2-carboxaldehyde, further the solution of chalcones in DMSO and few crystals of iodine was irradiated in a microwave oven for few minutes produces Flavones. It is an easy way to get high yield of product without intermediacy of O-aroylated intermediates. The structure of the synthesized compounds have been characterized by elemental analysis, IR, <su

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19

Whaley, William L., Ekua M. Okoso-amaa, Cody L. Womack, et al. "Summation Solute Hydrogen Bonding Acidity Values for Hydroxyl Substituted Flavones Determined by NMR Spectroscopy." Natural Product Communications 8, no. 1 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800121.

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The flavonoids are a structurally diverse class of natural products that exhibit a broad spectrum of biochemical activities. The flavones are one of the most studied flavonoid subclasses due to their presence in dietary plants and their potential to protect human cells from reactive oxygen species (ROS). Several flavone compounds also mediate beneficial actions by direct binding to protein receptors and regulatory enzymes. There is current interest in using Quantitative Structure Activity Relationships (QSARs) to guide drug development based on flavone lead structures. This approach is most in

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20

Mahalle, P. R., and N. T. Khaty. "Synthesis of Some Bromo-Substituted 3-Aroyl Flavanones and Flavones." E-Journal of Chemistry 7, no. 4 (2010): 1359–61. http://dx.doi.org/10.1155/2010/158274.

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A series of bromo-substituted 3-aroyl flavanons and flavones have been synthesized. The identities of the new compounds synthesized have been developed on the basis of usual chemical transformation and IR, NMR spectral studies.

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21

Elser, David, Christian Gilli, Lothar Brecker, and Karin M. Valant-Vetschera. "Striking Diversification of Exudate Profiles in Selected Primula Lineages." Natural Product Communications 11, no. 5 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100506.

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In continuation of previous studies on glandular exudates of Primula. we analyzed eleven so far unstudied species and several populations for exudate composition. Unsubstituted flavone and unusually substituted flavones, normally predominant in Primula exudates, were not detected in all of the analyzed samples. Instead, some species exhibited regular substituted flavonoids, and in some cases, no flavonoids could be detected at all. The detection of a diterpene (1) in P. minima exudates is new to Primula. On basis of MS and NMR, 1 was structurally characterized as ent-kaur-16-en-19-oic acid. Co

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22

Ghias, Mehreen, Syed Wadood Ali Shah, Fakhria A. Al-Joufi, et al. "In Vivo Antistress Effects of Synthetic Flavonoids in Mice: Behavioral and Biochemical Approach." Molecules 27, no. 4 (2022): 1402. http://dx.doi.org/10.3390/molecules27041402.

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Natural flavonoids, in addition to some of their synthetic derivatives, are recognized for their remarkable medicinal properties. The present study was designed to investigate the in vitro antioxidant and in vivo antistress effect of synthetic flavonoids (flavones and flavonols) in mice, where stress was induced by injecting acetic acid and physically through swimming immobilization. Among the synthesized flavones (F1–F6) and flavonols (OF1–OF6), the mono para substituted methoxy containing F3 and OF3 exhibited maximum scavenging potential against DPPH (2,2-diphenyl-1-picrylhydrazyl) with IC50

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23

Wollenweber, Eckhard, Marion Dörr, Abdolhossein Rustaiyan, James N. Roitman, and Earl H. Graven. "Notes: Exudate Flavonoids of Some Salvia and a Trichostema Species." Zeitschrift für Naturforschung C 47, no. 9-10 (1992): 782–84. http://dx.doi.org/10.1515/znc-1992-9-1025.

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Seven species of Salvia and one species of Trichostema were analyzed for their exudate flavonoids. They were found to exhibit flavonoid aglycones in various numbers and different patterns. Most of these are flavones, in which 6-methoxy-substituted compounds predominate.

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24

Zhao, Wannian, Ping Xie, Zhaogang Bian, et al. "Generation of ArS-substituted flavone derivatives using aryl thiols as sulfenylating agents." RSC Advances 5, no. 74 (2015): 59861–64. http://dx.doi.org/10.1039/c5ra10763f.

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25

Panova, Mariya A., Konstantin V. Shcherbakov, Ekaterina F. Zhilina, Yanina V. Burgart, and Victor I. Saloutin. "Synthesis of Mono- and Polyazole Hybrids Based on Polyfluoroflavones." Molecules 28, no. 2 (2023): 869. http://dx.doi.org/10.3390/molecules28020869.

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The possibility of functionalization of 2-(polyfluorophenyl)-4H-chromen-4-ones, with them having different numbers of fluorine atoms, with 1,2,4-triazole or imidazole under conditions of base-promoted nucleophilic aromatic substitution has been shown. A high selectivity of mono-substitution was found with the use of an azole (1.5 equiv.)/NaOBut(1.5 equiv.)/MeCN system. The structural features of fluorinated mono(azolyl)-substituted flavones in crystals were established using XRD analysis. The ability of penta- and tetrafluoroflavones to form persubstituted products with triazole under azole (6

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26

M., B. HOGALE, N. PAWAR B., and P. NIKAM B. "Synthesis and Biological Activity of some New Flavones." Journal of Indian Chemical Society Vol. 64, Aug 1987 (1987): 486–87. https://doi.org/10.5281/zenodo.6199891.

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Department of Chemistry, Shivaji University, Kolhapur-416 004 <em>Manuscript received 3 June 1986, revised 29 January 1987, accepted 10 July 1987</em> A number of variously substituted flavones have been synthesised and tested for their antibacterial and antifungal activities. The structures of these compounds were confirmed by ir, pmr and elemental analysis.

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27

Lim, Da-Som, Do-Hyung Lim, Ji-Ho Lee, Eun-Tae Oh, and Young-Soo Keum. "Structure–Oxidative Metabolism Relationships of Substituted Flavones byAspergillus niger." Journal of Agricultural and Food Chemistry 65, no. 14 (2017): 3056–64. http://dx.doi.org/10.1021/acs.jafc.7b00390.

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28

Wang, Xuejun, Jianli Liu, Yilin Zhang, and Xuhua Liang. "An efficient one-pot synthesis of 4′-substituted flavones." Chemical Papers 72, no. 1 (2017): 229–33. http://dx.doi.org/10.1007/s11696-017-0275-8.

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29

Desideri, N., C. Conti, I. Sestili, P. Tomao, M. L. Stein, and N. Orsi. "In vitro Evaluation of the Anti-Picornavirus Activities of New Synthetic Flavonoids." Antiviral Chemistry and Chemotherapy 6, no. 5 (1995): 298–306. http://dx.doi.org/10.1177/095632029500600503.

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Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhino-virus type 1B and poliovirus type 2 by a plaque reduction assay in HeLa cell cultures. Among the substituted flavanones only 6-chloro-4′-oxazolinylflavanone showed activity against both viruses. A comparison of the effects of 3-substituted flavones indicated that the presence of a 3-methoxy group enhances the activity against rhinovirus, whil

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30

Kerr, Penelope J., Simon M. Pyke, and A. David Ward. "Synthesis, and Cyclization to Aurones and Flavones, of Alkoxy-Substituted Aryl, Arylalkynyl Ketones." Australian Journal of Chemistry 61, no. 5 (2008): 350. http://dx.doi.org/10.1071/ch07348.

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Acylation of 1,3,5-tribenzyloxybenzene with alkoxy-substituted phenylpropioloyl chlorides provides the corresponding aryl alkoxylarylalkynyl ketones in which one of the benzyl groups has been removed. Cyclization of these phenolic ketones using basic reagents (potassium carbonate in acetone is best) provides the corresponding aurone system. When the phenolic group of the alkynyl ketones is protected as the t-butyldimethylsilyl ether followed by cyclization, using 18-crown-6 and potassium fluoride, mixtures of the corresponding aurones and flavones are produced. A by-product from the formation

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31

SKoya, Mustafa, Nada A Elamin, and Zeinab A Elrabei. "Isolation and Structural Elucidation of three Substituted Flavones from Croton Zambesicus (Mull) Fruit and Leaves." International Journal of Science and Research (IJSR) 10, no. 5 (2021): 444–48. https://doi.org/10.21275/sr21428180455.

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32

Ares, Jeffrey J., Pamela E. Outt, Jared L. Randall, et al. "Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents." Journal of Medicinal Chemistry 38, no. 25 (1995): 4937–43. http://dx.doi.org/10.1021/jm00025a011.

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33

Pal, Manojit, Karuppasamy Parasuraman, Venkataraman Subramanian, Rambabu Dakarapu, and Koteswar Rao Yeleswarapu. "Palladium mediated stereospecific synthesis of 3-enynyl substituted thioflavones/flavones." Tetrahedron Letters 45, no. 11 (2004): 2305–9. http://dx.doi.org/10.1016/j.tetlet.2004.01.113.

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34

Lu, Yu-Fang, Michael Santostefano, Bernadette D. M. Cunningham, Michael D. Threadgill, and Stephen Safe. "Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists." Biochemical Pharmacology 51, no. 8 (1996): 1077–87. http://dx.doi.org/10.1016/0006-2952(96)00063-9.

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35

Shcherbakov, Konstantin V., Yanina V. Burgart, Victor I. Saloutin, and Oleg N. Chupakhin. "Modification of Polyfluoro-Containing 3-(Ethoxycarbonyl)flavones by Biogenic Amines and Amino Acids." Current Organic Synthesis 15, no. 5 (2018): 707–14. http://dx.doi.org/10.2174/1570179415666180405120706.

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Aim and Objective: The objective of our work was to study the peculiarities of transformations of fluorine-containing flavone-3-carboxylates with N-nucleophiles, including biogenic amines and amino acids. Materials and Methods: 6,7,8-Trifluoro and 5,6,7,8-tetrafluoroflavone-3-carboxylates were involved in interactions with a number of N-nucleophiles, such as pyrrolidine, morpholine, proline, arginine, gammaaminobutyric acid, beta-alanine, histamine, dopamine and amantadine under different reaction conditions. All synthesized compounds were characterized by NMR 1H, 19F, (NMR 13C for some compou

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36

Kónya, Krisztina, and Zoltán Sipos. "Synthesis of 1,3-Azol-2-yl O-Heterocycles by Microwave-Irradiation-Assisted Direct C–H Functionalization." Synlett 29, no. 18 (2018): 2412–16. http://dx.doi.org/10.1055/s-0037-1611012.

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A microwave-irradiation-assisted synthesis of novel 1,3-azol-2-yl-substituted O-heterocycles, namely flavones, chromones, coumarins, and chromanones, is reported. Starting from the appropriate bromo derivatives and 1,3-azoles, this palladium and copper co-catalyzed method provides moderate to good yields and excellent regioselectivity. The ligand- and base-free method can be a useful, generally applicable synthetic tool in the formation of new O-heterocycles.

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37

Roehri-Stoeckel, Christine, Emmanuel Gonzalez, André Fougerousse, and Raymond Brouillard. "Synthetic dyes: simple and original ways to 4-substituted flavylium salts and their corresponding vitisin derivatives." Canadian Journal of Chemistry 79, no. 7 (2001): 1173–78. http://dx.doi.org/10.1139/v01-089.

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Flavylium salts substituted at the 4-position have been prepared according to a Grignard reaction of some flavones with appropriate alkyl- and aryl-magnesium bromides. Among these compounds, 4-methyl flavylium salts were gently reacted with aromatic aldehydes, affording new anthocyanidin pigments, some of which are of the vitisin family. These are the first examples of chemically synthesized vitisidins (aglycones of vitisins). Compared to the more common flavylium salts, they demonstrate a large bathochromic shift (from about 100200 nm), thus providing blue-violet and green colours, so diffic

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38

Németh-Rieder, Alexandra, Péter Keglevich, Attila Hunyadi, Ahmed Dhahir Latif, István Zupkó, and László Hazai. "Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids." Molecules 28, no. 2 (2023): 626. http://dx.doi.org/10.3390/molecules28020626.

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Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect.

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39

Košmrlj, Berta, and Boris Šket. "Photocyclization of 2-Chloro-Substituted 1,3-Diarylpropan-1,3-diones to Flavones." Organic Letters 9, no. 20 (2007): 3993–96. http://dx.doi.org/10.1021/ol701654c.

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Oganesyan, E. T., and S. S. Shatokhin. "USE OF QUANTUM-CHEMICAL PARAMETERS FOR FORECASTING ANTIRADICAL (HO·) ACTIVITY OF RELATED STRUCTURES CONTAINING A CINNAMIC MOLD FRAGMENT. III. CHALCONES, FLAVANONES AND FLAVONES WITH PHLOROGLUCINIC TYPE OF RING “A”." Pharmacy & Pharmacology 8, no. 6 (2021): 446–55. http://dx.doi.org/10.19163/2307-9266-2020-8-6-446-455.

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42 derivatives of chalcone, flavanone and flavone having a phloroglucinic type of ring “A” and containing the same electron-donating substituents on ring “B”, have been studied. Flavonoids with the phloroglucinic type of ring “A” are the most common in nature, which is due to the peculiarities of biogenetic formation with the participation of malonyl and acetyl fragments.The aim of the article is to determine the effect of the hydroxy group in position 6' of chalcones and in position 5 of flavanones and flavones on bond numbers (Nµ), free valence indices (Fµ), Mulliken charges (a.e), electron

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Mahnashi, Mater H., Mohammed Abdulrahman Alshahrani, Mohammed H. Nahari, et al. "In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease." Metabolites 12, no. 11 (2022): 1055. http://dx.doi.org/10.3390/metabo12111055.

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Plants’ bioactives are well-known safe drugs for vital diseases. Flavones and Flavonoid-rich dietary supplements are known to exhibit neuroprotective potential. In this study, we isolated a flavone 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-4H-chromen-4-one from Notholirion thomsonianum and it was evaluated against various targets of the oxidative stress-related neurological disorders. The compound showed excellent acetyl and butyrylcholinesterase inhibitions in its profile, giving IC50 values of 1.37 and 0.95 μM, respectively. Similarly, in in-vitro MAO-B assay, our flavone exhibited an IC50 value

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Salame, Rim, Zakaria Cheikh-Ali, Christian Bories, Marcelline Adiko, Erwan Poupon, and Pierre Champy. "Pyrone and Unusually Furanone-substituted Flavones from the Leaves of Hoslundia opposita." Planta Medica 78, no. 16 (2012): 1777–79. http://dx.doi.org/10.1055/s-0032-1315256.

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Sultana, Shahnaz, Mohammed Ali, Shahid Hussain Ansari, and Priyanka Bagri. "New 4′-substituted flavones from the fruit peels ofCitrus limon(L.) Burm.f." Journal of Asian Natural Products Research 10, no. 12 (2008): 1123–27. http://dx.doi.org/10.1080/10286020802434953.

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Ullah Mughal, Ehsan, Muhammad Ayaz, Zakir Hussain, et al. "Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones." Bioorganic & Medicinal Chemistry 14, no. 14 (2006): 4704–11. http://dx.doi.org/10.1016/j.bmc.2006.03.031.

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ARES, J. J., P. E. OUTT, J. L. RANDALL, et al. "ChemInform Abstract: Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents." ChemInform 27, no. 16 (2010): no. http://dx.doi.org/10.1002/chin.199616163.

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Conti, Cinzia, Paola Mastromarino, Paola Goldoni, Gustavo Portalone, and Nicoletta Desideri. "Synthesis and Anti-Rhinovirus Properties of Fluoro-Substituted Flavonoids." Antiviral Chemistry and Chemotherapy 16, no. 4 (2005): 267–76. http://dx.doi.org/10.1177/095632020501600406.

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Fluoro-substituted flavones and 2-styrykhromones, related to natural and synthetic flavonoids previously described, were prepared, characterized and tested for anti-rhinovirus activity. Structural elucidation of the new compounds was performed by IR, NMR spectra and X-ray crystal structure analysis for 6-fluoro-3-hydroxy-2-styrylchromone. The antiviral potency was evaluated by a plaque reduction assay in HeLa cell cultures infected with rhinoviruses 1B and 14, selected as representative serotypes for viral groups B and A of human rhinoviruses, respectively. In comparison with results previousl

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Do, Lien, Thammarat Aree, Pongpun Siripong, et al. "Cytotoxic Flavones from the Stem Bark of Bougainvillea spectabilis Willd." Planta Medica 84, no. 02 (2017): 129–34. http://dx.doi.org/10.1055/s-0043-118102.

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AbstractFive new flavones possessing a fully substituted A-ring with C-6 and C-8 methyl groups, bougainvinones I – M (1–5), along with three known congeners, 2′-hydroxydemethoxymatteucinol (6), 5,7,3′,4′-tetrahydroxy-3-methoxy-6,8-dimethylflavone (7) and 5,7,4′-trihydroxy-3-methoxy-6,8-dimethylflavone (8), were isolated from the EtOAc extract of the stem bark of Bougainvillea spectabilis. Their structures were established by means of spectroscopic data (ultraviolet, infrared, high-resolution electrospray ionization mass spectrometry, and one-dimensional and two-dimensional nuclear magnetic res

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Mioc, Ubavka, Jasmina Dimitric-Markovic, and Jelisaveta Baranac. "A study of the IR spectra of copigments formed by malvin chloride with flavones." Journal of the Serbian Chemical Society 65, no. 4 (2000): 245–53. http://dx.doi.org/10.2298/jsc0004245m.

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Research into the essence of the process of copigmentation of anthocyan molecules was continued by applying IR spectroscopy, in an attempt to elucidate the formation mechanism of copigment molecules between malvin chloride and several variously substituted flavones. Analysis of the IR spectra of the formed copigments revealed that the process of copigmentation is achieved via the formation of hydrogen bonds. The strength of the formed hydrogen bonds was correlated with the equilibrium constants of the processes of copigmentation of these molecules. The found correlation was in accordance with

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Gu, Landy, Nghia Tran, Vanessa M. Rangel, et al. "5-Substituted Flavones—Another Class of Potent Triplex DNA-Specific Ligands as Antigene Enhancers." Molecules 29, no. 24 (2024): 5862. https://doi.org/10.3390/molecules29245862.

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In the field of drug development, the quest for novel compounds that bind to DNA with high affinity and specificity never ends. In the present work, we report the newest development in this field, namely, triplex DNA-specific binding ligands based on the 5-substituted flavone scaffold in our lab. Biophysical studies showed that the newly synthesized flavone derivatives (depending on the side chains) bind to triplex DNA with binding affinities better than or similar to 5-substituted 3,3′,4′,7-tetramethoxyflavonoids. These compounds selectively stabilize triplex DNA while having little effect on

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Kładna, Aleksandra, Paweł Berczyński, Oya Bozdağ Dündar, et al. "Synthesis and in vitro antioxidant activity of new pyrimidin/benzothiazol-substituted piperazinyl flavones." Future Medicinal Chemistry 10, no. 19 (2018): 2293–308. http://dx.doi.org/10.4155/fmc-2018-0206.

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