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Dissertations / Theses on the topic 'Subunit vaccines'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Pinitkiatisakul, Sunan. "Recombinant subunit vaccines against Neospora caninum /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200740.pdf.

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2

Andersson, Christin. "Production and delivery of recombinant subunit vaccines." Doctoral thesis, KTH, Biotechnology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3027.

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<p>Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. In addition, different strategies fordelivery of subunit vaccines by RNA or DNA immunization havebeen investigated.</p><p>Attempts to create general production strategies forrecombinant protein immunogens in such a way that these areadapted for association with an adjuvant formulation wer

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3

Yang, Jyh-Chyang. "Liposome-based subunit and DNA hepatitis B vaccines." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367733.

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4

Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.

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5

Wong, Yim-ping. "Development of a subunit vaccine against foot-and-mouth disease virus /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21080161.

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6

Liljeqvist, Sissela. "Recombinant subunit vaccines : protein immunogens, live bacteria and nucleic acids /." Stockholm : Tekniska högsk, 1998. http://www.lib.kth.se/abs98/lilj0520.pdf.

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7

com, movahedi ar@gmail, and Abdolreza Movahedi. "A reverse vaccinology approach to identifying subunit proteins for use in vaccines against Brachyspira pilosicoli infections in humans and animals." Murdoch University, 2008. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20090318.140633.

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The anaerobic intestinal spirochaete Brachyspira pilosicoli is the causative agent of intestinal spirochaetosis (IS), a disease of humans and a number of animal species. IS has been reported in adults and children worldwide but the prevalence in people living in poor hygienic conditions, indigenous populations, homosexual males, and in immunocompromised people is much higher than in other populations. IS is also widespread in pigs and chickens, and causes significant economic impact in the associated industries. To date attempts to develop a vaccine against B. pilosicoli to protect humans an

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8

Young, Natalie Jane. "Bovine Viral Diarrhoea Virus Subunit Vaccines : Contribution of Non-Structural Proteins." Thesis, Royal Veterinary College (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498686.

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9

Peagram, Rebecca Elizabeth. "Emulsion formulations as delivery systems for soluble protein subunit viral vaccines." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363615.

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10

Zmolek, Andrew Charles. "Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/115019.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 105-113).<br>The poor efficacy of subunit protein vaccines, which typically consist of a protein antigen and a molecular adjuvant, has recently been improved by completing multiple injections of the vaccine with an exponential dosing profile over time. The hypothesis is that as viruses replicate in a host organism, they shed exponentially increasing quantities of pathogen associated molecular patterns (PAMPs) and

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11

Rau, Henriette. "Immunological approach for improving protein-based subunit vaccines against classical swine fever /." [S.l.] : [s.n.], 2005. http://www.zb.unibe.ch/download/eldiss/05rau_h.pdf.

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12

Hanke, Tomas. "Development of solid matrix-antibody-antigen (SMAA) complexes as multivalent subunit vaccines." Thesis, University of St Andrews, 1994. http://hdl.handle.net/10023/13989.

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In the course of the work presented in this thesis, the construction of solid matrix-antibody-antigen (SMAA) complexes as vaccines was further developed. In particular, it was demonstrated that it is feasible to assemble SMAA complexes using a short oligopeptide tag (Pk) attached to the C-termini of antigens and a Pk tag- specific mAb SV5-P-k. In order to facilitate the purification of recombinant proteins for immunization purposes, a second affinity tag was attached to the antigen N-termini. Initially, the N-terminal tag was 26-kDa-large thrombin-removable glutathione S-transferase (GST), whi

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13

Hu, Jianzhong. "Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/39129.

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Since emerging in Europe and the US, PRRS has spread globally and become the most significant infectious disease currently devastating the swine industry. In the US alone, the economic losses caused by this disease amount to more than 560 million US dollars every year. Modified-live PRRSV vaccines (MLV) are the most effective option currently available for the control of the disease. MLVs can confer solid protection against homologous re-infection and have significant effects in reducing viral shedding. But the vaccine efficacy varies upon heterologous challenge. None of the current vaccines a

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14

Bruffaerts, Nicolas. "Preclinical studies on a new strategy combining the Bacillus of Calmette-Guérin with plasmid DNA-based subunit vaccines against tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209082.

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La tuberculose est une maladie contagieuse causée par les bactéries appartenant au complexe Mycobacterium tuberculosis. On estime près de neuf millions de nouveaux cas et un million de décès chaque année dans le monde. De plus, approximativement un tiers de la population mondiale est infecté de manière latente, donc à risque de développer la maladie. Le seul vaccin préventif jusqu’à présent disponible est le Bacille de Calmette-Guérin (BCG). Cependant, son efficacité contre la forme pulmonaire de la maladie, contagieuse et plus fréquente chez l’adulte, est extrêmement variable. Le développemen

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15

Young, Katie. "Development of native and recombinant mumps virus subunit nasal vaccines using Protollin technology." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92188.

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We sought to develop an inactivated nasal mumps virus (MuV) vaccine combined with the Protollin (Prl) adjuvant/delivery system. Antigen based on split Jones MuV was produced and characterized.<br>Eight-week old BALB/c female mice were vaccinated with two or three doses of MuV antigen (4 or 8 micrograms) with or without 4 micrograms of Prl. Weight and behaviours were monitored to assess safety, and serum, respiratory secretions and splenocytes were obtained at study termination to assess MuV-specific immunity.<br>All vaccines were well-tolerated. Administration of 8 micrograms of MuV-Prl ind

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16

Wong, Yim-ping, and 黃艷萍. "Development of a subunit vaccine against foot-and-mouth disease virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221993.

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17

Cockle, Paul Jason. "Identification of novel 'Mycobacterium tuberculosis' antigens with potential as diagnostic reagents or subunit vaccines." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431063.

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18

Johnson, Nicholas. "Construction of a novel epitope expression vector based on the B-subunit of the diphtheria toxin." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296057.

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19

Aiyedebinu, Adetoun Olufolake. "Circumvention of bottlenecks in the manufacture of influenza subunit vaccines using aqueous two-phase systems." Thesis, University of Birmingham, 2002. http://etheses.bham.ac.uk//id/eprint/4177/.

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The experiments documented in this thesis investigate the use of aqueous two-phase systems (ATPS) as a viable method for the processing of influenza virus particles in a feedstock derived from embryonated hen's eggs. The virus particles are currently purified in an industrial process using stages of sucrose density gradient ultracentrifugation that produce a subunit vaccine Fluvirin which consists of the immunoprotective antigens haemagglutinin (HA) and neuraminidase (NA). The current purification scheme suffers process bottlenecks in particular, limitations of scale hence volumetric throughpu

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20

Balogh, Aaron Michael. "Virulence characterization of Rift Valley fever virus strains and efficacy of glycoprotein subunit vaccines in mice." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/34625.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Juergen A. Richt<br>Rift Valley fever virus (RVFV) is a vector-borne zoonotic pathogen endemic to sub-Saharan Africa and the Arabian Peninsula that causes severe disease in ruminants and humans. RVFV is a significant threat to US livestock and public health due to a lack of licensed, efficacious vaccines and its ability to become established in non-endemic areas. Subunit vaccine candidates based on RVFV N- and C-terminal glycoproteins (Gn and Gc) are a viable option for use in ruminants due to their ease of production, safe

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21

Kotzé, Lara. "Development of Pichia pastoris as a production system for HPV16 L1 virus-like particles as component to a subunit vaccine /." Link to the online version, 2007. http://hdl.handle.net/10019/435.

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22

Gomez, Sheena Robin. "Investigation of pertussis toxin A- and B-subunit activities in acellular vaccines by enzymatic and carbohydrate-binding assays." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/40959/.

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Pertussis toxin (PT) is a major virulence factor produced by Bordetella pertussis. In its detoxified form (PTd), it is an important component of acellular pertussis vaccines although some residual FT activity may be present because of the limitations of the detoxification processes used. The in vivo histamine sensitisation test (HIST) in mice is currently used for the safety testing of these vaccines to determine the level of their residual FT activity. However, an alternative test is needed because of large assay variability and ethical concerns with regard to animal usage. The main objective

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23

Jain, Neeta. "Approaches towards therapeutic development against chronic brucellosis in a mouse model." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77039.

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Brucellosis is the most common zoonotic disease worldwide. The intracellular localization of Brucella hinders the action of drugs that poorly cross cell membrane barriers. Additionally, when the immune response fails to clear the infection, chronic brucellosis ensues that becomes more challenging to treat with antibiotics. Therefore, two approaches, intracellular drug delivery and immunostimulation, have been explored in this dissertation, with an aim to develop a better therapeutic against Brucella infection in mice. First, to overcome the cell membrane barriers, drug loaded nanoparticles we

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24

Thoma, Michelle C. "Regulating the regulators using CD25 depletion to enhance immune responses to a model plasmid-based vaccine /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5764.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "August 2008" Includes bibliographical references.

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25

Movahedi, Abdolreza. "A reverse vaccinology approach to identifying subunit proteins for use in vaccines against Brachyspira pilosicoli infections in humans and animals." Movahedi, Abdolreza (2008) A reverse vaccinology approach to identifying subunit proteins for use in vaccines against Brachyspira pilosicoli infections in humans and animals. PhD thesis, Murdoch University, 2008. http://researchrepository.murdoch.edu.au/744/.

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The anaerobic intestinal spirochaete Brachyspira pilosicoli is the causative agent of “intestinal spirochaetosis” (IS), a disease of humans and a number of animal species. IS has been reported in adults and children worldwide but the prevalence in people living in poor hygienic conditions, indigenous populations, homosexual males, and in immunocompromised people is much higher than in other populations. IS is also widespread in pigs and chickens, and causes significant economic impact in the associated industries. To date attempts to develop a vaccine against B. pilosicoli to protect humans an

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26

Miller, Lilija [Verfasser], and Andreas [Akademischer Betreuer] Nitsche. "Expression Libraries as Tools for the Development of Subunit Vaccines and Novel Detection Molecules for Orthopoxviruses / Lilija Miller. Betreuer: Andreas Nitsche." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2011. http://d-nb.info/1018764836/34.

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27

Kotze, Lara. "Development of Pichia pastoris as a production system for HPV16 L1 virus-like particles as component to a subunit vaccine." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/1946.

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Human papillomavirus (HPV) is a sexually transmitted virus and known precursor to cervical cancer, the second most lethal cancer in females across the world. Two virus-like particle (VLP) vaccines exist that provide immunity against the main serotypes of the disease and are produced in Saccharomyces cerevisiae (S. cerevisiae) and baculovirus infected insect cells. Pichia pastoris (P. pastoris) was chosen as an alternative expression system for HPV VLP production based on its history as prolific heterologous protein producer that circumvent many of the problems associated with aforementio

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28

Ball, Glyn. "An evaluation of the Nippostrongylus brasiliensis infection in the rat as a model for the development of subunit vaccines against nematode parasites of ruminants." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/10717.

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<i>Nippostrongylus brasiliensis </i>is a GI nematode parasite of rodents and is an extensively applied laboratory model for defining the immune mechanisms that mediate worm expulsion. <i>N. brasiliensis </i>infection in the rat shares many similarities with <i>Trichostrongylus </i>infection in ruminants including, importantly, the functional proteins secreted or excreted by the nematode (ES proteins). Several of these ES proteins are potential candidates for vaccines. The aim of this project was to use the rat/<i>Nippostrongylus </i>parasite system as a model for vaccination with recombinant E

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29

Bacelo, Kátia Leston. "Adjuvantes: impacto na eficácia de vacina de subunidade contra leptospirose." Universidade Federal de Pelotas, 2013. http://guaiaca.ufpel.edu.br/handle/123456789/1227.

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Made available in DSpace on 2014-08-20T13:32:49Z (GMT). No. of bitstreams: 1 tese_katia_leston_bacelo.pdf: 1389207 bytes, checksum: b5ad0bea30c73a3ecb9d5b196b2a8b64 (MD5) Previous issue date: 2013-12-10<br>A major challenge for the development of vaccines based on purified or recombinant protein subunits, and synthetic peptides resides in the fact that these are poorly immunogenic and mobilize insufficient immunoprotective response. Adjuvants are often used in association with these subunits in order to amplify and direct the immune response induced. Nowadays, there is a wide range of com

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30

Ye, Lilin. "FcRn mediated mucosal immunity and subunit vaccine delivery." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9815.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Virginia-Maryland Regional College of Veterinary Medicine. Maryland Campus. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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31

Gallovic, Matthew D. "Acid-Sensitive Polymer Microparticles for Subunit Vaccine Delivery." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468803443.

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32

Yeung, Wing-shing, and 楊永成。. "Development of a subunit vaccine against infectious bursal disease virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222055.

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33

Harney, B. A. "Investigations of a subunit vaccine in experimental herpes simplex keratitis." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375020.

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34

Yeung, Wing-shing. "Development of a subunit vaccine against infectious bursal disease virus /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2066817X.

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35

Leal, Irene Sofia Viana Guimarães Moreira. "Cytokines as pontential cadjuvants in a subunit vaccine against tuberculosis." Tese, Universidade do Porto. Reitoria, 2001. http://hdl.handle.net/10216/10078.

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Dissertação de Doutoramento em Ciências Biomédicas apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto<br>A tuberculose (TB) é uma doença infecciosa que ainda hoje é responsável pela morte de aproximadamente dois milhões de pessoas por ano, apesar da existência da vacina do BCG para a prevenir e de vários regimes de antibióticos bem definidos para a tratar. Nas últimas décadas, o uso da vacina do BCG tornou-se altamente controverso uma vez que foi demonstrado que a sua eficácia protectora podia variar desde 0 a 80%. Uma vacina mais eficaz poderia ajudar a s

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36

Leal, Irene Sofia Viana Guimarães Moreira. "Cytokines as pontential cadjuvants in a subunit vaccine against tuberculosis." Doctoral thesis, Universidade do Porto. Reitoria, 2001. http://hdl.handle.net/10216/10078.

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Dissertação de Doutoramento em Ciências Biomédicas apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto<br>A tuberculose (TB) é uma doença infecciosa que ainda hoje é responsável pela morte de aproximadamente dois milhões de pessoas por ano, apesar da existência da vacina do BCG para a prevenir e de vários regimes de antibióticos bem definidos para a tratar. Nas últimas décadas, o uso da vacina do BCG tornou-se altamente controverso uma vez que foi demonstrado que a sua eficácia protectora podia variar desde 0 a 80%. Uma vacina mais eficaz poderia ajudar a s

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37

Parmar, Manjeet M. "Development and characterization of a liposomal subunit vaccine against Neisseria gonorrhoeae." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0021/NQ46405.pdf.

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38

Tamizifar, Hassan. "Enhancement of subunit influenza vaccine with diptheria - tetanus - pertussis (DTP) vaccination." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388739.

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39

Henriksen, Malou. "Formulation and development of cationic liposomes as adjuvants for subunit protein vaccinese." Thesis, Aston University, 2011. http://publications.aston.ac.uk/14668/.

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Liposomes remain at the forefront of vaccine design due to their well documented abilities to act as delivery vehicles and adjuvants. Liposomes have been described to initiate an antigen depot-effect, thereby increasing antigen exposure to circulating antigen-presenting cells. More recently, in-depth reviews have focussed on inherent immunostimulatory abilities of various cationic lipids, the use of which is consequently of interest in the development of subunit protein vaccines which when delivered without an adjuvant are poorly immunogenic. The importance of liposomes for the mediation of an

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Carre, Heather Emily. "Expression and analysis of recombinant mycoplasma hyponeumoniae proteins as potential subunit vaccine candidates." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522182.

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41

Mokoena, Tinyiko. "Expression and Purification of an efficacious recombinant Pulpy Kidney subunit vaccine made in N. Benthamiana." Thesis, University of Pretoria, 2016. http://hdl.handle.net/2263/65917.

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Epsilon toxin (Etx) produced by Clostridium perfringens type D is responsible for a fatal Enterotoxemia (Pulpy Kidney Disease) in economically significant livestock such as sheep and goats. The only practical means of controlling this disease is by immunisation and avoiding the circumstances that are conducive to its occurrence. All currently available Pulpy Kidney Disease vaccines are based on a formalinised toxoid of Clostridium perfringens (Welchii) type D. This is either as an alum-precipitate, oil-emulsion formulation of the whole cell culture or a bacterial culture filtrate (Deepika, 201

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Pan, Yen-Chiang, and 潘彥江. "Development of recombinant subunit vaccines for infectious coryza." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/92215888127216099231.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>99<br>Infectious coryza (IC) is an acute upper-respiratory disease caused by infection with Avibacterium paragallinarum. The disease is distributed worldwide and causes significant economic loss of poultry industry. In Taiwan, more than one hundred million doses of IC vaccine have been used every year to control the disease. The goal of this study is twofold. The first is to use the next generation sequencing technology to conduct sequence analyses of the complete genome of Av. paragallinarum strain H18, which is a serovar C reference strain. The result showed t

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Hsiao, Meng-Jen, and 蕭孟仁. "Development of king grouper iridovirus (KGIV) subunit and DNA vaccines." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/09454635508240562488.

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碩士<br>國立高雄大學<br>生物科技研究所<br>95<br>Iridovirues have been demonstrated the epizootic agents that causative mass mortality in king grouper (Epinephelus lanceolatus) cultured in Taiwan. Primers (OSGIV-08L-F & OSGIV-08L-R), designed according to the DNA sequence of orange-spotted grouper iridovirus (OSGIV), were used to amplify the ORF-8L of the KGIV. The amplicons (1606 bp) were revealed have an 1485bp open reading frame that predicted to encode 485 amino acids, a putative transmembrane protein (485 amino acids). The amplicons (1606bp) was reveal have sequence similer to (94~99%) myristylated membr

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Wu, Jin-Ru, and 吳靜如. "Development of subunit vaccines and gene-deficient live vaccines for Pasteurella multocida that causes fowl cholera." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/34135945257241910765.

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博士<br>國立中興大學<br>獸醫微生物學研究所<br>95<br>Fowl cholera is caused by Pasteurella multocida (P. multocida) that leads to an acute septicemia of chickens and ducks. The outbreak of this disease usually causes economic losses in the poultry industry worldwide. Vaccines of fowl cholera have been used in the field, but the efficacy is unsatisfactory. The goal of this study is to develop a new type of subunit vaccine and gene-deficient live vaccine for P. multocida. We first screened for the presence of virulence-related genes in plasmids harbored by P. multocida. We hoped that the virulence-related gen

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Chiang, Yao-An, and 江曜安. "The development of recombinant toxin subunit vaccines against swine progressive atrophic rhinitis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/7e28r2.

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碩士<br>國立宜蘭大學<br>生物技術與動物科學系生物技術碩士班<br>101<br>Progressive atrophic rhinitis (PAR), caused by toxigenic Pasteurella multocida (P. multocida) and virulent Bordetella bronchiseptica (B. bronchiseptica) is an important upper respiratory disease in swine. Previous studies have shown that Pasteurella multocida toxin (PMT) isolated from P. multocida is the major virulence factor of PAR. Thus PMT has been considered as a good immunogenic candidate for vaccine development. This also suggests that the determination of the immunogenic fragments of PMT that can elicit a strong and protective immune response

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Jang, Yun, and 張勻. "Construction of genetic recombinant baculoviruses of PRRSV for preparation of subunit vaccines." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/82084739682888679958.

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碩士<br>國立中興大學<br>分子生物學研究所<br>101<br>Porcine reproductive and respiratory syndrome virus (PRRSV) belongs to the family of Arteriviridae. It causes severe reproductive failure in sows and respiratory disease in young pigs, although other signs such as fever, blue ear, weight loss, diarrhea, stillbirth, dyspnoea, pneumonia could be observed as well. PRRSV is an important swine disease that causes severe economic loss in the pig industry. Previous studies indicated that the structure proteins GP2, GP3, GP4, GP5 and M proteins can induce neutralizing antibodies against the virus. The aim of this stu

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Scanlen, Melinda. "Development of a candidate VP2-based subunit vaccine for African horsesickness virus serotype 5." Thesis, 2003. http://hdl.handle.net/2263/27687.

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African horse sickness (AHS) is a lethal disease of horses. The aetiological agent is African horsesickness virus (AHSV) (genus Orbivirus; family: Reoviridae). Immunity to all nine serotypes is needed for full protection. The AHSV virion is composed of seven structural proteins and 10 dsRNA genes. The outer capsid protein, VP2, determines the serotype and elicits protective neutralising antibodies (NAbs). The existing polyvalent attenuated vaccine has some drawbacks. The most important ones are the exclusion of serotypes 5 and 9. Also, vaccinated and naturally infected horses cannot be differe

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Yang, Chung-Dar, and 楊忠達. "Analysis of the protective capacity of SAG1 and SAG2 subunit vaccines in BALB/c mice." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/66220676777981902753.

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博士<br>國立中山大學<br>生物科學系研究所<br>92<br>IV 英文摘要 SAG1 and SAG2 are important surface molecules of T. gondii for the invasion of tachyzoites into host-cells. Previous studies have been demonstrated they are good candidates for development of vaccines against toxoplasmosis. Therefore, we used SAG1 and SAG2 to generate subunit vaccines and evaluated the protective capacity in BALB/c mice. Anti-idiotype IgG (aId-IgG) with the SAG2 internal image was prepared from anti-SAG2 monoclonal antibody in accordance with the network theory. Lymphocytes from mice immunized subcutaneously twice with 2, 4 or 8 µg aId

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LIN, HONG-YOU, and 林泓佑. "The study of efficacy and safety of recombinant toxin subunit vaccines against swine Actinobacillus pleuropneumoniae." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/46545781641456815907.

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Chih-Ming, Laio, and 廖志明. "The development and efficacy of recombinant subunit Pasteurella multocida toxin vaccines against swine progressive atrophic rhinitis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/45832357109921999565.

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博士<br>國立中興大學<br>獸醫學系<br>94<br>In this study, three recombinant subunit Pasteurella multocida toxins (rsPMTs) were constructed and expressed successfully. These rsPMTs were non-toxic both in mice and swine and could induce PMT-specific antibody-secreting cells and cellular immunity in spleen. The rsPMT-immunized mice could survive the lethal dose challenge of authentic PMT, and the PMT-specific antibody-secreting cells (ASCs) increased significantly. In addition, immunized piglets generated higher neutralizing antibody titers after authentic PMT challenge or homologous antigen boost. Furthermor

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