Relevant bibliographies by topics / Succinylcholine

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Succinylcholine'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Succinylcholine"

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M., Sajina, Medha A. Sangawar, Sangawar A. V., and Niraj Bannore. "Rocuronium for intubation in parturients undergoing caesarean section." International Journal of Research in Medical Sciences 6, no. 10 (September 25, 2018): 3441. http://dx.doi.org/10.18203/2320-6012.ijrms20184060.

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Background: Anaesthetic management of a parturient is a challenge because it involves simultaneous care of both mother and baby. Succinylcholine, a depolarizing muscle relaxant is most commonly used and considered “The Gold Standard’’ for tracheal intubation. Among currently available non-depolarizing neuromuscular blocking agent rocuronium bromide is the only agent that has rapid onset of action which is comparable to succinylcholine. Thus, rocuronium may provide alternative to succinylcholine for rapid sequence induction of anaesthesia wherever succinylcholine is contraindicated.Methods: In a control trial, 60 parturients of ASA grade I and II were randomly allocated in two groups of 30 patients each (group R and group S). After preoxygenation for a period of 5minutes rapid sequence induction done with thiopentone 5mg/kg for all patients. Muscle relaxant rocuronium (0.6mg/kg) was administered for group R. Succinylcholine was given in similar dosage (0.6mg/kg) for group S. The intubation was tried after 90 seconds in group R (rocuronium group) but after 60 seconds in group S (succinylcholie group). The intubating conditions were assessed and compared among the groups using criteria suggested by Cooper et al.Results: The mean intubation time was 98.3 seconds in group R and 67.9 seconds in group S. Rocuronium produced clinically acceptable intubating conditions in 28 out 30 patients (93.33%). Among these 28 patients 70% had excellent intubating conditions and 23.33% had good intubating conditions. Clinically acceptable intubating conditions were present in all 30 patients (100%-90% excellent and 10% good) who were administered succinylcholine. Succinylcholine produced excellent intubating conditions at 60 seconds (90 percent) compared to rocuronium (70 percent). However, this difference was statistically insignificant (p= 0.053). The mean Apgar score at 1 min and 5 min in group R was 8.1 and 8.83 as against 8.06 and 8.96 in babies born to mother in group S.Conclusions: Rocuronium (0.6mg/kg) provided acceptable intubation conditions after a waiting period of 90 seconds in 93.33% patients as against 100% patients in succinylcholine administered patients in equivalent dosage. So rocuronium is a promising alternative for rapid sequence induction in parturients in whom succinylcholine is not advisable or contraindicated.
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Mazur, Bartosz, Anna Greguła, Karol Stachyrak, Dawid Mika, Aleksandra Kłos, Kamila Turek, Maciej Lambach, Mateusz Pawlicki, Aleksandra Mazurek, and Wiktoria Wilanowska. "Safety and side effects of suxamethonium in clinical practice – literature overview." Journal of Education, Health and Sport 52 (January 11, 2024): 11–24. http://dx.doi.org/10.12775/jehs.2024.52.001.

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Introduction and purpose Muscle relaxants have been integral to medical practice for decades, benefiting both anesthesiologists for smooth patient intubation and surgeons requiring deep muscle relaxation. This article focuses on succinylcholine, a prominent muscle relaxant, exploring its historical context, efficacy, and the accumulated data on potential life-threatening side effects. The manuscript analyzes the available knowledge regarding the adverse effects of succinylcholine in clinical practice, presenting literature-identified methods aimed at risk mitigation. Summarizing the current understanding of succinylcholine's risks seeks to enhance its effective use, decrease adverse incidents in patients, and contribute to the overall safety of both patients and healthcare providers. Material and methods The following review of studies was based on articles obtained from the PubMed and Google Scholar databases. Key search terms included suxamethonium, succinylcholine, suxamethonium hyperkalemia, suxamethonium myalgia, suxamethonium anaphylaxis, suxamethonium cholinesterase deficiency, and suxamethonium malignant hyperthermia. Conclusions Suxamethonium's adverse effects range from muscle pain-related discomfort to rare, potentially lethal multi-organ complications, impacting patients' health diversely. Despite its drawbacks, succinylcholine remains crucial in anesthesiology. Ongoing research offers avenues to counteract or mitigate side effects. However, these methods necessitate further research to develop universal, widely available protocols in clinical settings.
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Hartman, Gregg S., Steven A. Fiamengo, and Walter F. Riker. "Succinylcholine." Anesthesiology 65, no. 4 (October 1, 1986): 405–13. http://dx.doi.org/10.1097/00000542-198610000-00010.

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Bedford, Robert F. "Succinylcholine." Anesthesia & Analgesia 81, no. 4 (October 1995): 883. http://dx.doi.org/10.1097/00000539-199510000-00043.

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Norman, John. "Succinylcholine." Current Opinion in Anaesthesiology 4, no. 4 (August 1991): 583–87. http://dx.doi.org/10.1097/00001503-199108000-00022.

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Bedford, Robert F. "Succinylcholine." Anesthesia & Analgesia 81, no. 4 (October 1995): 883. http://dx.doi.org/10.1213/00000539-199510000-00043.

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Martyn, Jeevendra, and Marcel E. Durieux. "Succinylcholine." Anesthesiology 104, no. 4 (April 1, 2006): 633–34. http://dx.doi.org/10.1097/00000542-200604000-00004.

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Bevan, David R. "Succinylcholine." Canadian Journal of Anaesthesia 41, no. 6 (June 1994): 465–68. http://dx.doi.org/10.1007/bf03011538.

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Jonsson, Malin, Michael Dabrowski, David A. Gurley, Olof Larsson, Edwin C. Johnson, Bertil B. Fredholm, and Lars I. Eriksson. "Activation and Inhibition of Human Muscular and Neuronal Nicotinic Acetylcholine Receptors by Succinylcholine." Anesthesiology 104, no. 4 (April 1, 2006): 724–33. http://dx.doi.org/10.1097/00000542-200604000-00017.

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Background Succinylcholine is one of the most widely used muscle relaxants in clinical anesthesia and emergency medicine. Although the clinical advantages and cardiovascular side effects are well known, its mechanism of action within the human nicotinic cholinergic receptor system remains to be understood. The aim of this study was to investigate the effect of succinylcholine on human muscle and neuronal nicotinic acetylcholine receptor (nAChR) subtypes. Methods Xenopus laevis oocytes were injected with human messenger RNA for muscle and neuronal nAChR subunits. Receptor activation, desensitization, and inhibition induced by the natural ligand acetylcholine or by succinylcholine was studied using a multichannel two-electrode voltage clamp setup. Responses were measured as peak current and net charge. Results Succinylcholine concentration-dependently activated the muscle-type nAChR with an EC50 value of 10.8 microm (95% confidence interval, 9.8-11.9 microm), and after the initial activation, succinylcholine desensitized the muscle-type nAChR. Succinylcholine did not activate the neuronal nAChR subtypes alpha3beta2, alpha3beta4, alpha4beta2, or alpha7 at concentrations up to 1 mm and was a poor inhibitor at these receptor subtypes, with IC50 values above 100 microm. Conclusion Succinylcholine activates the muscle-type nAChR followed by desensitization. The observation that succinylcholine does not inhibit the presynaptic alpha3beta2 autoreceptor at clinically relevant concentrations provides a possible mechanistic explanation for the typical lack of tetanic fade in succinylcholine-induced neuromuscular blockade. Finally, cardiovascular side effects (e.g., tachyarrhythmias) of succinylcholine are not mediated via direct activation of the autonomic ganglionic alpha3beta4 subtype because succinylcholine does not activate the neuronal nAChRs.
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Naguib, Mohamed, Abdulhamid Samarkandi, Waleed Riad, and Saleh W. Alharby. "Optimal Dose of Succinylcholine Revisited." Anesthesiology 99, no. 5 (November 1, 2003): 1045–49. http://dx.doi.org/10.1097/00000542-200311000-00006.

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Background The authors reappraised the conventional wisdom that the intubating dose of succinylcholine must be 1.0 mg/kg and attempted to define the lower range of succinylcholine doses that provide acceptable intubation conditions in 95% of patients within 60 s. Methods This prospective, randomized, double-blind study involved 200 patients. Anesthesia was induced with 2 mug/kg fentanyl and 2 mg/kg propofol. After loss of consciousness, patients were randomly allocated to receive 0.3, 0.5, or 1.0 mg/kg succinylcholine or saline (control group). Tracheal intubation was performed 60 s later. A blinded investigator performed all laryngoscopies and also graded intubating conditions. Results Intubating conditions were acceptable (excellent plus good grade combined) in 30%, 92%, 94%, and 98% of patients after 0.0, 0.3, 0.5, and 1.0 mg/kg succinylcholine, respectively. The incidence of acceptable intubating conditions was significantly greater (P < 0.05) in patients receiving succinylcholine compared with those in the control group but was not different among the different succinylcholine dose groups. The calculated doses of succinylcholine (and their 95% confidence intervals) that were required to achieve acceptable intubating conditions in 90% and 95% of patients at 60 s were 0.24 (0.19-0.31) mg/kg and 0.56 (0.43-0.73) mg/kg, respectively. Conclusions The use of 1.0 mg/kg of succinylcholine may be excessive if the goal is to achieve acceptable intubating conditions within 60 s. Comparable intubating conditions were achieved after 0.3, 0.5, or 1.0 mg/kg succinylcholine. In a rapid-sequence induction, 95% of patients with normal airway anatomy anesthetized with 2 mug/kg fentanyl and 2 mg/kg propofol should have acceptable intubating conditions at 60 s after 0.56 mg/kg succinylcholine. Reducing the dose of succinylcholine should allow a more rapid return of spontaneous respiration and airway reflexes.
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Dissertations / Theses on the topic "Succinylcholine"

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Archibald, Timothy, Stacy Brown, and Alexei Gonzalez-Estrada. "Refrigerated Stability of Diluted Succinylcholine, Pancuronium, and Atracurium." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/88.

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Refrigerated Stability of Diluted Succinylcholine, Pancuronium, and Atracurium. T. Archibald1, S. Brown1, A. Gonzalez-Estrada2 1College of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN2Quillen College of Medicine, Allergy and Clinical Immunology, East Tennessee State University, Johnson City, TN The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely succinylcholine, pancuronium, and atracurium, for skin prick/intradermal testing. Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Each drug was prepared with an n = 5 for each dilution, using a different newly opened product for each series. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days (day 0, 1, 2, 4, 7, and 14), one milliliter aliquots of each dilution were removed, filtered, and analyzed against freshly prepared set of reference dilutions. The results are expressed as beyond use date (BUD), defined as recovery of drug versus the reference (90-110%). Based on the LC-MS/MS data, the BUD for succinylcholine diluted by 10x and 100x is 48 and 24 hours, respectively. The1000x dilution is also stable for 24 hours.Higher dilutions of succinylcholine (10,000x to100,000x) should be used immediately following preparation (within less than 24 hours), as the potency of these dilutions had decreased below 90% at the 24 hr sampling. .Pancuronium diluted by 10x and 100x, had a BUD of 48 hours, and the1,000x dilution was stable for 24 hours.As with the succinylcholine, the 10,000x and 100,000x dilutions expressed potency of <90% at 24 hours. .Atracurium diluted to 10x had a BUD of 96 hours, the100x dilution is stable for 24 hours yet higher dilutions (1,000x to 10,000x) do not persist beyond 24 hours. . The 100,000x dilution of atracurium was unknown, given than the signal intensity was too weak to monitor by our LC-MS/MS method. With increasing dilution factors, the stability of these drugs in saline decreases, associated with an increasing deviation between samples and freshly prepared references. The most stable dilutions for each of the drugs tested were 10x and 100x. Stability of these drugs is likely compromised by hydrolysis of the ester bonds in the drug molecules.
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LAZZERINI, GENTILS SYLVIE. "Curarisation prolongee a la succinylcholine : a propos d'un cas." Toulouse 3, 1989. http://www.theses.fr/1989TOU31242.

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Rodgers, Justin Fraser. "Classification and projection strength of muscle spindle afferents." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309421.

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Faye, Sherry Ann. "Investigations on plasma cholinesterase in man and animals using succinylcholine as the substrate." Thesis, University of Leeds, 1988. http://etheses.whiterose.ac.uk/228/.

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A simple, precise "reaction rate" assay for plasma cholinesterase based on a succiny1choline substrate has been developed. It's ability to define individuals at risk of succiny1choline sensitivity and identify those who had experienced apnoea was superior to the previously best available assay. However it was not able to identify abnormal forms of cholinesterase which could hydrolyze conventional assay substrates but not succinylcholine. It was-concluded that if these forms exist their numbers are small. The failure to identify such cholinesterase types may have been because'the substrate concentration chosen for the assay was higher than that found"pharnacologically. However investigation of the kinetics of the succiny1choline-cholinesterase interaction showed that this was not the case. The assay was applied to the assessment of liver dysfunction and compared to three established methods was superior. All assays identified patients with severe liver disease but the succinylcholine-based one identified more patients with moderate/mild disease. The assay was also used to investigate the clinical observation that children require a higher dose of succiny1choline for muscle relaxation than adults. Infants were found to have higher succiny1choline activities than adults which is compatible with their relative resistance to the drug. Finally cholinesterase measurements were made, using a range of substrates including succinylcholine, in a variety of animal species. Results show that only when succiny1choline is used as the substrate for'the assay of cholinesterase does enzyme activity correlate with tolerance to it's muscle relaxant properties. The choice of procedure for the analysis of any biochemical variable depends on a number of criteria including ease of assay, precision, accuracy and cost; however the primary consideration should be the ability of the method to provide clinically useful information. Based on all these criteria, in particular the latter, succiny1choline must be considered as the substrate of choice.
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Price, Rupert Francis. "The use of succinylcholine in the identification and characterisation of afferent axons from tandem muscle spindles." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/20120.

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The drug succinylcholine (SCh) is known to produce contracture in two of the three classes of intrafusal muscle fibre whilst paralysing the third. Since the effects on afferent stretch sensitivity of contraction in each class of intrafusal muscle fibre are known, SCh can be used to assess the pattern of intrafusal termination of afferents studied electrophysiologically. This approach has previously been used to differentiate primary afferents from secondaries when alternative means were not applicable, but the aim of the present experiments has been to extend this work to allow the differentiation of primary afferents from classical spindle encapsulations (which have the full complement of intrafusal muscle fibres) and those from tandem encapsulations which lack a bag1 fibre which would otherwise be activated by SCh. Three sets of experiments were performed. In the first, afferents from the cat neck extensor muscle biventer cervicis were studied, since this muscle is known to be particularly rich in tandem spindles. Four types of afferent response to intraarterial infusion of SCh were identified, three corresponding to the behaviour previously reported for hindlimb muscle spindle afferents. The fourth had not previously been seen, and showed features which indicated that the afferents activated by SCh in this way were probably the b2c primary afferents arising in tandem muscle spindles. Other evidence in the form of the passive properties of these afferents was adduced to support this diagnosis. In the second series of experiments using the medial gastrocnemius muscle of the hindlimb, four patterns of SCh activation were again seen for muscle spindle afferents; these were all very similar to the patterns seen for biventer afferents, including that presumed to belong to b2c primary afferents from tandem spindles. Additional evidence that b2c primary afferents from tandem muscle spindles had been correctly identifed came from the measurement of their conduction velocities, which indicated that the majority of presumed b2c primary afferents from tandem muscle spindles had conduction velocities which overlapped with those of slower b1b2c primary afferents from classical encapsulations, as was expected on histological grounds. In the final series of experiments, the spindles of origin of afferents from the tenuissimus muscle which had been studied electrophysiologically were located in the muscle, excised and studied histologically in serial transverse sections. Seven afferents were diagnosed by SCh as primaries arising in classical muscle spindles, and the histological reconstruction indicated that their parent spindles indeed contained all three intrafusal muscle fibre types. In contrast, the single afferent diagnosed by SCh and a b2c primary arising in a tandem muscle spindle was subsequently found to innervate an encapsulation of a tandem spindle containing only two types of intrafusal muscle fibre. The histological evidence thus supports the SCh-based classification of primary afferents, and in particular indicates that b2c primary afferents from tandem muscle spindles can be readily identified during electrophysiological experiments.
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Early, Marvin E. "Comparison of Succinylcholine Induced Fasciculation Attenuation with Defasciculating Doses of Vecuronium and Mivacurium Based on Ideal Body Weight." VCU Scholars Compass, 1993. http://scholarscompass.vcu.edu/etd/4548.

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This study was conducted to determine if Mivacurium (Miv) was as effective as Vecuronium (Vec) in attenuating Succinylcholine (Sch)-induced fasciculations with muscle relaxant doses based upon ideal body weight (IBW). A quasi experimental design was used to study 60 patients who were randomly assigned to one of three groups. The two study groups were compared to a control group and each other with regards to the incidence and intensity of fasciculations. Either Vec (0.01 mg/kg (IBW)), Miv (0.02 mg/kg (IBW)), or saline (control) was administered in a double-blinded manner 3 minutes prior an intubating dose of Sch (IBW). Both pretreatment modalities resulted in a significant (p < .05) decrease in the incidence (Vec 40%, Miv 60%) and intensity of fasciculations when compared to saline (90%). No significant differences (p > .05) were found between the two pretreatment groups with regards to the incidence and intensity of fasciculations. It was concluded that Miv 0.02 mg/kg (IBW) attenuated Sch-induced fasciculations with the same efficacy as Vec 0.01 mg/kg (IBW).
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Overdiek, Ronda Michele. "A comparison of the incidence and degree of postoperative myalgia and muscle fasciculations associated with dose and duration of succinylcholine administration /." Full Text (HTML) Full Text (PDF) Abstract, 2008. http://eprints.ccsu.edu/archive/00000500/02/1956FT.htm.

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Thesis (M.S.) -- Central Connecticut State University, 2008.
Thesis advisor: Ruth Rollin. "... in partial fulfillment of the requirements for the degree of Master of Science in Biological Sciences: Anesthesia." Includes bibliographical references (leaves 73-86). Also available via the World Wide Web.
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Pettersson, Maria. "Förebyggande av postoperativ myalgi." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5222.

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Succinylcolin är ett icke-depolariserande muskelrelaxantia som används inom anestesisjukvård. En vanlig biverkning är postoperativ myalgi. Varför smärtan uppstår är inte helt klarlagd. Under många år har forskare runt om i världen försökt komma till rätta med problemet utan att helt lyckas.Olika läkemedel och strategier har prövats. En av de viktigaste uppgifter en sjuksköterska har är att förebygga och lindra lidande. Som anestesisjuksköterska finns det möjlighet att påverka den vård som ordineras. Syftet med studien var att undersöka vilka metoder som kan förebygga postoperativ myalgi orsakad av succinylcolin. En litteraturstudie baserad på tio vetenskapliga artiklar genomfördes. Resultatet visade att parecoxib preoperativt samt premedicinering med diklofenakplåster gav det bästa resultatet när det gäller reducerande av myalgi. Med hjälp av dessa så vanliga läkemedel kan onödigt lidande förebyggas och samhällsekonomiska resurser sparas.

 

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Damin, Craig Anthony. "Instrument Development and Application for Qualitative and Quantitative Sample Analyses Using Infrared and Raman Spectroscopies." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1385774823.

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Groseanu, Stefan-Andrei [Verfasser], and Grietje [Akademischer Betreuer] Beck. "Muskelrelaxation mit Mivacurium bei starren Bronchoskopien - Eine Alternative zu Succinylcholin? / Stefan-Andrei Groseanu ; Betreuer: Grietje Beck." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1204637628/34.

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Books on the topic "Succinylcholine"

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Gertler, Ralph. Intubationsbedingungen und Wirkprofil nach Org 9487 im Vergleich zu Succinylcholin bei Blitz-Narkoseeinleitung von Erwachsenen. [s.l.]: [s.n.], 1999.

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Kayla, Carl. Anectine (succinylcholine Chloride) Injection, Usp. Independently Published, 2018.

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HARRIS, Kayla. Anectine (succinylcholine Chloride) Injection, Usp. Independently Published, 2018.

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BRIGHT, James. Anectine (succinylcholine Chloride) Injection, Usp. Independently Published, 2018.

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The Effect of Rapacuronium or Succinylcholine on the Duration of Action of Rocuronium. Storming Media, 2001.

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Pollard, Brian J. Muscle relaxants in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0047.

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The place of neuromuscular blocking agents in the intensive care unit (ICU) has changed markedly over the last 20 years. Originally regarded as a mainstay of the process of ‘sedation’, they are now only used for specific indications. The principal disadvantage is probably the difficulty in neurological assessment when a muscle relaxant is used coupled with the increased risk of awareness, because inadequate sedation will be masked. Of the available agents, the intermediate acting ones are the most popular. The degree of relaxation can be readily controlled and they have few side effects. In the presence of renal and/or hepatic disease atracurium or cisatracurium are preferred. Succinylcholine is only used for securing the airway due to its very rapid onset of action. Rocuronium given in a higher dose also possesses a rapid onset in situations when succinylcholine might be contraindicated. When using a muscle relaxant, its effect should always be monitored with a simple train of four pattern of stimulation from a hand-held nerve stimulator. This will ensure that an adequate and not excessive block is secured. If a more rapid reversal is required then a dose of neostigmine with glycopyrrolate may be used. Alternatively, if rocuronium is the relaxant in use then the new agent sugammadex is effective.
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Kreeger, Renee, and James P. Spaeth. Muscular Dystrophy. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0058.

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Duchenne muscular dystrophy (DMD) is a complex disease characterized by multiple physiologic perturbations, progressively leading to cardiomyopathy, respiratory failure, and, eventually, death. Patients with DMD create unique challenges for the anesthesia team, including management of a difficult airway, avoidance of volatile anesthetics and succinylcholine, the need for respiratory support, and discussion of advance directives. A thorough and multidisciplinary collaborative approach must be utilized in the care of these patients for the entire perioperative period. This chapter uses a case example of a 17-year-old boy with DMD who presents for preoperative anesthesia consultation in anticipation of percutaneous endoscopic gastrostomy tube placement.
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Hunter, Jennifer M., and Thomas Fuchs-Buder. Neuromuscular blockade and reversal. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0016.

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Over the past 70 years since the introduction of d-tubocurarine, the search for an ideal neuromuscular blocking agent has led to the development of the depolarizing drug, succinylcholine (suxamethonium), with its rapid onset of action and plasma metabolism, and a series of non-depolarizing agents of which there are two groups: benzylisoquinoliniums (e.g. atracurium, cisatracurium and mivacurium) and aminosteroidal agents (e.g. pancuronium, vecuronium and rocuronium). The need to monitor neuromuscular block perioperatively to ensure the appropriate dose of any neuromuscular blocking drug is given has led to the development of several nerve stimulation techniques. Particularly useful clinically are the train-of-four twitch response, double-burst stimulation, and the post-tetanic count. Their benefits and limitations are considered in this chapter. The most suitable equipment to monitor neuromuscular block and the appropriate anatomical sites for stimulation are discussed. To prevent residual block with its pathophysiological consequences such as upper airway and pharyngeal dysfunction and potential respiratory failure at the end of surgery, antagonizing agents are used. These are of two types: anticholinesterases such as neostigmine and edrophonium, and the γ‎-cyclodextrin, sugammadex. The pharmacodynamics and pharmacokinetics of neuromuscular blocking drugs and their antagonists are altered by the extremes of age, obesity, and several disease states including renal and hepatic failure, neuromuscular disorders, and critical illness. The altered response to all these drugs in these pathologies, which is related to their metabolism and excretion, is considered in detail, together with their other side-effects including the particular disadvantages to the use of succinylcholine.
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Heine, Christopher L. Malignant Hyperthermia. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0025.

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In this chapter we discuss the pathophysiology of malignant hyperthermia, identify those who are known to be susceptible to MH, delineate how best to prepare the operating for those patients, and provide step by step treatment recommendations for patients that develop MH. Malignant hyperthermia (MH) is a pharmacogenetic disease. When susceptible individuals are exposed to a triggering agent, a hypermetabolic response develops. Succinylcholine and halogenated, inhaled anesthetics are triggers of MH. The MH reaction is initiated by a rapid influx of calcium ions into the myoplasm that triggers uncontrolled muscle contraction. Prompt recognition and treatment of the reaction is critical to a successful outcome.
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Levy, David M., and Ieva Saule. General anaesthesia for caesarean delivery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0022.

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General anaesthesia (GA) is most often indicated for category 1 (immediate threat to life of mother or baby) caesarean delivery (CD) or when neuraxial anaesthesia has failed or is contraindicated. Secure intravenous access is essential. Jugular venous cannulation (with ultrasound guidance) is required if peripheral access is inadequate. A World Health Organization surgical safety checklist must be used. The shoulders and upper back should be ramped. Left lateral table tilt or other means of uterine displacement are essential to minimize aortocaval compression, and a head-up position is recommended to improve the efficiency of preoxygenation and reduce the likelihood of gastric contents reaching the oropharynx. Cricoid pressure is controversial. In the United Kingdom, thiopental remains the induction agent of choice, although there is scant evidence upon which to avoid propofol. In pre-eclampsia, it is essential to obtund the pressor response to laryngoscopy with remifentanil or alfentanil. Rocuronium is an acceptable alternative to succinylcholine for neuromuscular blockade. Sugammadex offers the possibility of swifter reversal of rocuronium than spontaneous recovery from succinylcholine. Management of difficult tracheal intubation is focused on ‘oxygenation without aspiration’ and prevention of airway trauma. The Classic™ laryngeal mask airway is the most commonly used rescue airway in the United Kingdom. There is a large set of data from fasted women of low body mass index who have undergone elective CD safely with a Proseal™ or Supreme™ laryngeal mask airway. Sevoflurane is the most popular volatile agent for maintenance of GA. The role of electroencephalography-based depth of anaesthesia monitors at CD remains to be established. Intraoperative end-tidal carbon dioxide tension should be maintained below 4.0 kPa.
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Book chapters on the topic "Succinylcholine"

1

Maxwell, Robert A., and Shohreh B. Eckhardt. "Succinylcholine." In Drug Discovery, 283–96. Totowa, NJ: Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0469-5_21.

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de Groot, Anton C. "Succinylcholine." In Monographs In Contact Allergy, 890. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-454.

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Holmstedt, Bo, Ingrid Nordgren, Gun Jacobsson, Inga Jäderholm-Ek, and Torsten Silander. "Succinylcholine — Clinical and Toxicological Aspects." In Neurobiology of Acetylcholine, 419–26. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5266-2_33.

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Nordgren, I. "Succinylcholine — A Method of Determination. Distribution and Elimination." In Advances in Behavioral Biology, 757–66. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5194-8_74.

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Feuer, Matthew Patrick, and Thomas M. Chalifoux. "Blocked Again: Effects of Repeated Doses of Succinylcholine." In A Case Approach to Perioperative Drug-Drug Interactions, 413–16. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_89.

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Chern, Shoei-Cherng, Rong-Yaw Chang, and Shen-Kou Tsai. "Neuromuscular Interaction Between Succinylcholine and Esmolol in the Rat." In Muscle Relaxants, 411. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_112.

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Jalkanen, Larisa, Olli A. Meretoja, and Tomi Taivainen. "Neuromuscular Effects of Mivacurium When Preceded by Succinylcholine in Children." In Muscle Relaxants, 359. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_60.

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Abou-Madi, M., D. Trop, and K. Kardash. "Succinylcholine, Motor Deficits, Intracranial Hypertension and Potassium Levels in Brain Tumor Patients." In Intracranial Pressure VIII, 668–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77789-9_148.

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Yasuda, Seiichi, Junzo Takeda, Hiromasa Sekiguchi, and Kazuaki Fukushima. "Augmentation of Succinylcholine on the Neuromuscular Blocking Effect of Vecuronium in Pediatrics." In Muscle Relaxants, 375. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_76.

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Schoppmeyer, M. A., and S. S. Schäfer. "Time-Dependent Responses of Muscle Spindle Ia-Afferents on a Long Lasting Succinylcholine Infusion." In Alpha and Gamma Motor Systems, 277–79. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_60.

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Conference papers on the topic "Succinylcholine"

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Kalaji, W., J. Sargi, K. Nangrani, O. Adarkwah, N. Mesiha, J. Zeibeq, and L. N. Gerolemou. "Succinylcholine-Induced Cardiac Arrest in a Young Patient with Malignant Hyperthermia." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3423.

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Vedashree, Y., S. Balabhaskar, D. Srinivasalu, and H. Balasubramanya. "Efficacy of Magnesium Sulphate in Attenuation of Succinylcholine Induced Fasciculations - A Dose Finding Study." In ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter. Indian Society of Anaesthesiologists (ISA), 2017. http://dx.doi.org/10.18311/isacon-karnataka/2017/fp040.

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Adderley, P., C. Tejera Quesada, and C. Dorta. "Alerted by the Wrong Electrogram: A Case of Cardiac Arrest Post Succinylcholine Administration During an Electroencephalogram." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1811.

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